Receptor
PDB id Resolution Class Description Source Keywords
3AXY 2.4 Å NON-ENZYME: OTHER STRUCTURE OF FLORIGEN ACTIVATION COMPLEX CONSISTING OF RICE HD3A, 14-3-3 PROTEIN GF14 AND RICE FD HOMOLOG OSFD1 ORYZA SATIVA JAPONICA GROUP PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 14-3-3 PROTEIN BZPROTEIN FLORAL INDUCTION TRANSCRIPTIONAL ACTIVATOR SIGNAPROTEIN DNA BINDING PHOSPHORYLATION NUCLEUS SIGNALING PPROTEIN BINDING COMPLEX
Ref.: 14-3-3 PROTEINS ACT AS INTRACELLULAR RECEPTORS FOR FLORIGEN NATURE V. 476 332 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LEU GLN ARG VAL LEU SEP ALA PRO PHE E:189;
F:189;
K:189;
L:189;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
866.911 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3AXY 2.4 Å NON-ENZYME: OTHER STRUCTURE OF FLORIGEN ACTIVATION COMPLEX CONSISTING OF RICE HD3A, 14-3-3 PROTEIN GF14 AND RICE FD HOMOLOG OSFD1 ORYZA SATIVA JAPONICA GROUP PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 14-3-3 PROTEIN BZPROTEIN FLORAL INDUCTION TRANSCRIPTIONAL ACTIVATOR SIGNAPROTEIN DNA BINDING PHOSPHORYLATION NUCLEUS SIGNALING PPROTEIN BINDING COMPLEX
Ref.: 14-3-3 PROTEINS ACT AS INTRACELLULAR RECEPTORS FOR FLORIGEN NATURE V. 476 332 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 3AXY - LEU GLN ARG VAL LEU SEP ALA PRO PHE n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: LEU GLN ARG VAL LEU SEP ALA PRO PHE; Similar ligands found: 120
No: Ligand ECFP6 Tc MDL keys Tc
1 LEU GLN ARG VAL LEU SEP ALA PRO PHE 1 1
2 ARG SER LEU SEP ALA PRO GLY ASN 0.541667 0.917808
3 VAL MET ALA PRO ARG THR LEU PHE LEU 0.537975 0.794872
4 ARG SEP PRO VAL PHE SER 0.522876 0.943662
5 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.519481 0.835616
6 ARG ARG ALA SEP ALA PRO LEU PRO 0.493421 0.930556
7 ALA PHE ARG ILE PRO LEU THR ARG 0.487342 0.826667
8 ACE ALA GLU GLY PHE PRO ALA TPO VAL 0.485507 0.859155
9 ACE ARG THR PRO SEP LEU PRO THR 60H 0.484663 0.907895
10 ACE ARG THR PRO SEP LEU PRO THR PIP 0.48366 0.894737
11 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.480769 0.943662
12 ASN ALA ARG SER ALA SEP PHE SER GLN GLY 0.47482 0.75
13 TRP ASP ILE PRO PHE 0.473684 0.722222
14 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.473684 0.797297
15 DPN PRO ARG 0.469697 0.771429
16 ACE PRO ALA PRO PHE 0.46875 0.684932
17 LEU PRO PHE GLU ARG ALA THR VAL MET 0.467836 0.772152
18 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.467836 0.729412
19 ALA MET ALA PRO ARG THR LEU LEU LEU 0.467105 0.769231
20 LEU PRO PHE GLU LEU ARG GLY HIS LEU VAL 0.465116 0.776316
21 ASP ASP LEU ASP VAL PRO SER PHE LEU GLN 0.464516 0.77027
22 ARG THR PHE SER PRO THR TYR GLY LEU 0.463855 0.797468
23 ARG THR PRO SEP LEU PRO THR 49F 0.463576 0.891892
24 ARG THR PRO SEP LEU PRO THR 0.463576 0.891892
25 PHE ASN ARG PRO VAL 0.462585 0.808219
26 VAL PRO LEU ARG PRO MET THR TYR 0.457317 0.765432
27 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.457143 0.766234
28 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.456954 0.773333
29 ARG LEU TYR HIS SEP LEU PRO ALA 0.45614 0.860759
30 SER SER PHE TYR PRO SEP ALA GLU GLY 0.455696 0.769231
31 ARG PHE PRO LEU THR PHE GLY TRP 0.454545 0.7625
32 THR THR ALA PRO PHE LEU SER GLY LYS 0.453988 0.773333
33 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.453416 0.766234
34 DPN PRO DAR ILE NH2 0.450704 0.788732
35 DPN PRO DAR DTH NH2 0.450704 0.780822
36 TYR ASP LEU SEP LEU PRO PHE PRO 0.448485 0.797468
37 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.447853 0.851351
38 ACE ARG THR PRO SEP LEU PRO GLY D3W 0.447514 0.851852
39 TYR MET ASP PHE ASP ASP ASP ILE PRO PHE 0.445312 0.704225
40 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.444444 0.821918
41 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.443114 0.763158
42 LYS PRO VAL LEU ARG THR ALA 0.441558 0.797297
43 DPN PRO DAR CYS NH2 0.439716 0.736111
44 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.437909 0.824324
45 PRO LYS ARG PRO THR THR LEU ASN LEU PHE 0.4375 0.792208
46 ARG TYR PRO LEU THR PHE GLY TRP 0.437158 0.743902
47 ACE ARG THR PRO SEP LEU PRO GLY D4H 0.436464 0.896104
48 LEU LEU PHE GLY LYS PRO VAL TYR VAL 0.436364 0.6625
49 ARG THR PRO SEP LEU PRO GLY D4K 0.435754 0.85
50 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.435294 0.813333
51 ASN LYS ASN ALA ASN SEP SER PRO VAL 0.435065 0.802632
52 0G6 0.433824 0.72
53 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.432749 0.688312
54 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.431694 0.769231
55 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.430851 0.765432
56 ACE LYS ARG ARG LYS SEP VAL 0.430657 0.774648
57 LEU LEU PHE GLY TYR PRO VAL TYR VAL 0.429448 0.679487
58 LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.429448 0.679487
59 VAL ORN LEU DPN PRO VAL ORN LEU DPN PRO 0.428571 0.702703
60 ACE ARG THR PRO SEP LEU PRO GLY D3Q 0.425532 0.8625
61 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.42487 0.746988
62 ACE ARG TYR ALA VAL VAL PRO ASP GLU 0.424837 0.76
63 ARG VAL ALA SEP PRO THR SER GLY VAL 0.423313 0.891892
64 ACE ARG THR PRO SEP LEU PRO GLY D3K 0.42328 0.821429
65 ARG ARG GLN ARG SEP ALA PRO 0.422535 0.835616
66 ARG PRO MET THR PHE LYS GLY ALA LEU 0.422222 0.78481
67 ARG SER HIS SEP SER PRO ALA SER LEU GLN 0.422222 0.87013
68 LEU PRO PHE ASP ARG THR THR ILE MET 0.421965 0.775
69 LEU PRO PHE GLU ARG ALA THR ILE MET 0.421348 0.7625
70 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.420382 0.819444
71 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.419753 0.753247
72 LYS PRO PHE PTR VAL ASN VAL GLU PHE 0.41954 0.7625
73 THR PRO SEP LEU PRO DAL 60H 0.419355 0.828947
74 TYR PRO LYS ARG ILE ALA 0.41875 0.753247
75 ARG SER ALA SEP GLU PRO SER LEU 0.418182 0.905405
76 LYS PRO PHE PTR VAL ASN VAL NH2 0.418182 0.75
77 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.417647 0.776316
78 ALA ARG SER HIS SEP TYR PRO ALA 0.417143 0.825
79 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.416667 0.789474
80 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.416149 0.808219
81 ASN ARG PRO ILE LEU SER LEU 0.415584 0.813333
82 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.415301 0.848101
83 ALA ASN SER ARG HIS PRO THR SER ILE ILE 0.414634 0.782051
84 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.414201 0.773333
85 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.414013 0.833333
86 ALA DAL PRO PHE NIT 0.412587 0.654321
87 PRO SEP LEU PRO DVA 60H 0.411392 0.851351
88 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.410405 0.688312
89 DHI PRO PHE HIS LEU LEU VAL TYR 0.410405 0.6625
90 ARG GLY PRO GLY CYS ALA PHE VAL THR ILE 0.410112 0.815789
91 LYS PRO SEP GLN GLU LEU 0.409722 0.873239
92 HIS PRO PHE 0.408759 0.64
93 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.408046 0.7875
94 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.407821 0.740741
95 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.407643 0.824324
96 GLY PHE ARG PRO 0.407143 0.774648
97 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.406977 0.662651
98 ILE SER PRO ARG THR LEU ASP ALA TRP 0.406417 0.7875
99 TYR LEU ALA PRO GLY PRO VAL THR ALA 0.40625 0.730769
100 ALA CYS SEP PRO GLN PHE GLY 0.40625 0.821918
101 ACE ALA ALA ARG LBZ SER ALA PRO ALA 0.406061 0.835616
102 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.405714 0.84
103 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.405556 0.772152
104 ACE SER LEU ARG PRO ALA PRO LPD 0.405229 0.824324
105 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.404624 0.815789
106 THR PRO PRO SER PRO PHE 0.404255 0.72973
107 PHE GLU ASP LEU ARG VAL LEU SER PHE 0.403727 0.68
108 ARG THR TYR SEP GLY PRO MET ASN LYS VAL 0.403141 0.831325
109 THR LYS PRO ARG 0.402985 0.732394
110 ALA ARG MLZ SER ALA PRO ALA THR 0.402516 0.792208
111 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.402367 0.776316
112 1IP CYS PHE SER LYS PRO ARG 0.402367 0.802632
113 ALA PRO ASP THR ARG PRO ALA PRO 0.401316 0.776316
114 LEU PRO SER PHE GLU THR ALA LEU 0.401235 0.77027
115 LEU PHE GLY TYR PRO VAL TYR VAL 0.401235 0.679487
116 PHE PRO THR LYS ASP VAL ALA LEU 0.401198 0.746667
117 LYS PRO ILE VAL VAL LEU HIS GLY TYR 0.40113 0.666667
118 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.401099 0.743902
119 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.40107 0.756098
120 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.4 0.647059
Similar Ligands (3D)
Ligand no: 1; Ligand: LEU GLN ARG VAL LEU SEP ALA PRO PHE; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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