Receptor
PDB id Resolution Class Description Source Keywords
3CF6 2.2 Å NON-ENZYME: OTHER STRUCTURE OF EPAC2 IN COMPLEX WITH CYCLIC-AMP AND RAP MUS MUSCULUS EPAC RAPGEF4 RAP RAP1B CAMP SP-CAMPS GEF GUNANINE NUCEXCHANGE FACTOR G-PROTEIN GTP-BINDING NUCLEOTIDE-BINDINGSIGNALING PROTEIN REGULATOR-GTP-BINDING PROTEIN COMPLEX SIPROTEIN-GTP-BINDING PROTEIN COMPLEX
Ref.: STRUCTURE OF EPAC2 IN COMPLEX WITH A CYCLIC AMP ANA RAP1B NATURE V. 455 124 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 R:168;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
SP1 E:2;
E:3;
Valid;
Valid;
none;
none;
submit data
345.272 C10 H12 N5 O5 P S c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3CF6 2.2 Å NON-ENZYME: OTHER STRUCTURE OF EPAC2 IN COMPLEX WITH CYCLIC-AMP AND RAP MUS MUSCULUS EPAC RAPGEF4 RAP RAP1B CAMP SP-CAMPS GEF GUNANINE NUCEXCHANGE FACTOR G-PROTEIN GTP-BINDING NUCLEOTIDE-BINDINGSIGNALING PROTEIN REGULATOR-GTP-BINDING PROTEIN COMPLEX SIPROTEIN-GTP-BINDING PROTEIN COMPLEX
Ref.: STRUCTURE OF EPAC2 IN COMPLEX WITH A CYCLIC AMP ANA RAP1B NATURE V. 455 124 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 3CF6 - SP1 C10 H12 N5 O5 P S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SP1; Similar ligands found: 87
No: Ligand ECFP6 Tc MDL keys Tc
1 SP1 1 1
2 RP1 1 1
3 2BA 0.757143 0.915493
4 CMP 0.757143 0.928571
5 1YD 0.580645 0.844156
6 4BW 0.580645 0.844156
7 Y3J 0.542857 0.702703
8 5AD 0.529412 0.722222
9 QQX 0.519481 0.90411
10 XYA 0.514286 0.77027
11 ADN 0.514286 0.77027
12 RAB 0.514286 0.77027
13 5CD 0.513889 0.756757
14 1SY 0.509615 0.844156
15 5N5 0.5 0.746667
16 4UR 0.5 0.844156
17 CC5 0.5 0.791667
18 A4D 0.493151 0.77027
19 MTA 0.480519 0.75
20 75G 0.476744 0.932432
21 EP4 0.473684 0.708861
22 1OR 0.472527 0.759036
23 DTA 0.467532 0.810811
24 M2T 0.467532 0.7125
25 7D7 0.458333 0.72
26 ACK 0.45679 0.835616
27 3AD 0.453333 0.780822
28 SRA 0.451219 0.918919
29 1YC 0.45098 0.818182
30 3DH 0.45 0.75
31 3AM 0.444444 0.851351
32 J7C 0.440476 0.703704
33 ZAS 0.439024 0.721519
34 QQY 0.439024 0.890411
35 AMP 0.439024 0.864865
36 A 0.439024 0.864865
37 6RE 0.433735 0.695122
38 2AM 0.432099 0.84
39 AMP MG 0.428571 0.818182
40 DSH 0.428571 0.703704
41 NEC 0.428571 0.679487
42 A3G 0.428571 0.730769
43 AOC 0.428571 0.75
44 6SX 0.425287 0.885714
45 A2D 0.423529 0.866667
46 A3N 0.423529 0.717949
47 ABM 0.423529 0.842105
48 EEM 0.419355 0.651163
49 S4M 0.418605 0.647727
50 GJV 0.418605 0.686747
51 OVE 0.416667 0.88
52 6SZ 0.41573 0.915493
53 ADX 0.41573 0.82716
54 MAO 0.413793 0.697674
55 7CH 0.413793 0.914286
56 BA3 0.413793 0.866667
57 A3P 0.413793 0.864865
58 AP2 0.413793 0.810127
59 A12 0.413793 0.810127
60 ADP BEF 0.411111 0.7875
61 BEF ADP 0.411111 0.7875
62 5X8 0.411111 0.74026
63 50T 0.411111 0.831169
64 SFG 0.411111 0.705128
65 S7M 0.410526 0.670588
66 5AS 0.409091 0.758621
67 B4P 0.409091 0.866667
68 AP5 0.409091 0.866667
69 ADP 0.409091 0.842105
70 APC 0.406593 0.810127
71 5F1 0.405063 0.688312
72 A3S 0.404494 0.74026
73 SON 0.404494 0.810127
74 A7D 0.404494 0.753247
75 AN2 0.404494 0.831169
76 7D5 0.402439 0.805195
77 AGS 0.402174 0.894737
78 AD9 0.402174 0.820513
79 SAP 0.402174 0.894737
80 SA8 0.402174 0.666667
81 CA0 0.4 0.820513
82 N6R 0.4 0.853333
83 M33 0.4 0.831169
84 ADP MG 0.4 0.807692
85 MHZ 0.4 0.659091
86 AU1 0.4 0.820513
87 N6S 0.4 0.853333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3cf6.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found: 604
This union binding pocket(no: 2) in the query (biounit: 3cf6.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1OTH PAO 0.005013 0.4097 1.79641
2 3UXL CFI 0.03052 0.41276 1.82768
3 3KO8 NAD 0.0005928 0.445 1.92308
4 2H8Z 8CM 0.005281 0.40495 1.94986
5 2H8Z FMN 0.005281 0.40495 1.94986
6 2RGH FAD 0.001626 0.43782 2.39521
7 2B4Q NAP 0.003217 0.41441 2.53623
8 3NYQ AMP 0.002164 0.42489 2.57426
9 3NYQ MCA 0.002002 0.42489 2.57426
10 3A2Q ACA ACA 0.000808 0.4171 2.63692
11 1JH7 UVC 0.01053 0.40392 2.6455
12 1GR0 NAD 0.01172 0.4248 2.7248
13 4KQI NIO 0.000464 0.44761 2.80899
14 4KQI RBZ 0.000464 0.44761 2.80899
15 1G0N NDP 0.006504 0.41211 2.82686
16 1G0N PHH 0.008719 0.41006 2.82686
17 3SFI 3SF 0.003653 0.424 2.9661
18 4FWE FAD 0.0006853 0.45581 2.99401
19 4O1M NAD 0.000516 0.44438 2.99401
20 2D2I NAP 0.0004197 0.43947 2.99401
21 4JP3 CIT 0.001635 0.42954 2.99401
22 2V6O FAD 0.01073 0.42642 2.99401
23 1GEX PLP HSA 0.001203 0.42437 2.99401
24 1I0Z OXM 0.012 0.42322 2.99401
25 1QPB PYM 0.002245 0.41594 2.99401
26 1QPB TPP 0.002245 0.41594 2.99401
27 2H6B 3C4 0.01112 0.41565 2.99401
28 1MVQ MMA 0.003394 0.41487 2.99401
29 9LDB NAD 0.004577 0.40994 2.99401
30 9LDT NAD 0.004752 0.40932 2.99401
31 1JUV NDP 0.0004603 0.44147 3.10881
32 1RYI FAD 0.0003737 0.46406 3.14136
33 1RYI GOA 0.001411 0.44335 3.14136
34 1K27 MTM 0.006023 0.40666 3.18021
35 2HNK SAH 0.00251 0.40385 3.34728
36 1PL6 572 0.005206 0.41029 3.37079
37 3OIG NAD 0.01112 0.41844 3.38346
38 3OIG IMJ 0.005588 0.40911 3.38346
39 4PO2 ASN ARG LEU LEU LEU THR GLY 0.001921 0.41177 3.40426
40 1OFH ADP 0.002165 0.41496 3.44828
41 3BY8 MLT 0.001747 0.44808 3.52113
42 1ML4 PAL 0.001958 0.40868 3.57143
43 3H9E NAD 0.0002474 0.45148 3.59281
44 4GYW UDP 0.0007979 0.44009 3.59281
45 2DTX BMA 0.002367 0.43035 3.59281
46 2WA4 069 0.0006689 0.42768 3.59281
47 2CKM AA7 0.00578 0.41713 3.59281
48 3P3N AKG 0.007301 0.4137 3.59281
49 1YBH FAD 0.007683 0.41029 3.59281
50 1TB4 PEJ 0.005037 0.40706 3.59281
51 3W54 RNB 0.001056 0.40579 3.59281
52 4OB6 S2T 0.001511 0.40529 3.59281
53 4L7I SAM 0.001931 0.40379 3.59281
54 3H86 AP5 0.01851 0.40092 3.59281
55 2HW1 ANP 0.0002627 0.44101 3.69128
56 2FWP ICR 0.008573 0.40425 3.82514
57 2FWP CIT 0.007139 0.40261 3.82514
58 4EPL JAI 0.001644 0.404 3.95869
59 3MTW M3R 0.001943 0.40147 3.97022
60 1U7Z PMT 0.002705 0.42118 3.9823
61 1QY1 PRZ 0.0001826 0.44668 4.02299
62 1NZY BCA 0.0004867 0.44222 4.08922
63 3O03 NAP 0.003037 0.41106 4.12371
64 4P3H 25G 0.01301 0.40583 4.14508
65 3IU9 T07 0.01025 0.41924 4.16667
66 4PLG OXM 0.00003311 0.50021 4.19162
67 4PLG NAI 0.00003311 0.50021 4.19162
68 3KMZ EQO 0.00021 0.45411 4.19162
69 2P8B NSK 0.005783 0.45066 4.19162
70 3FC4 EDO 0.001816 0.4471 4.19162
71 3WE0 FAD 0.001913 0.43811 4.19162
72 1X54 4AD 0.0004875 0.43708 4.19162
73 1BGQ RDC 0.0006858 0.43505 4.19162
74 3MAG 3MA 0.01059 0.43383 4.19162
75 4JK3 NAD 0.001131 0.43007 4.19162
76 1YS4 NAP 0.0008411 0.42476 4.19162
77 4KCF AKM 0.001062 0.42292 4.19162
78 2NCD ADP 0.003531 0.42142 4.19162
79 1F1V DHY 0.002574 0.4159 4.19162
80 2QCX PF1 0.005456 0.41342 4.19162
81 2Q2V NAD 0.005715 0.40874 4.19162
82 3EAU PDN 0.0345 0.40672 4.19162
83 3EAU NDP 0.0345 0.40672 4.19162
84 1WL4 COA 0.01262 0.4055 4.19162
85 1DAK ADP 0.01192 0.40374 4.19162
86 1DAK DPU 0.01192 0.40374 4.19162
87 1UMP SQA 0.005177 0.40097 4.19162
88 3CXO 1N5 0.008131 0.40046 4.19162
89 2QS8 MET 0.007087 0.40014 4.19162
90 1Q7E MET 0.002118 0.41688 4.20561
91 1UKW FAD 0.01247 0.40004 4.22164
92 1WVC CTP 0.008956 0.43404 4.2471
93 4LSJ LSJ 0.001417 0.41468 4.26357
94 3K3K A8S 0.001584 0.41099 4.2654
95 3TN7 NJP 0.001184 0.4322 4.28016
96 1MVN PCO 0.003278 0.43856 4.30622
97 1WXI AMP 0.01369 0.40042 4.36364
98 1JQI FAD 0.0002403 0.46548 4.38144
99 1JQI CAA 0.0001295 0.45819 4.38144
100 1F5F DHT 0.0006119 0.42134 4.39024
101 3LZW NAP 0.005344 0.43093 4.51807
102 3LZW FAD 0.002147 0.43093 4.51807
103 1R37 NAD 0.002263 0.42538 4.61095
104 2PNZ UDP 0.002877 0.4104 4.69314
105 2F01 BTQ 0.03593 0.40016 4.72441
106 4IZC 1GZ 0.02075 0.40125 4.72727
107 1P9B IMO 0.001272 0.4218 4.75113
108 1RKD ADP 0.0006023 0.44474 4.79042
109 1RKD RIB 0.0006023 0.44474 4.79042
110 1WDA BAG 0.0006013 0.44082 4.79042
111 3E8N VRA 0.001795 0.43821 4.79042
112 3E8N ATP 0.001795 0.43821 4.79042
113 1ZFJ IMP 0.0104 0.43595 4.79042
114 3TO7 COA 0.002206 0.43046 4.79042
115 2NLI FMN 0.004448 0.42881 4.79042
116 2NLI LAC 0.004448 0.42881 4.79042
117 1ZK7 FAD 0.004298 0.42597 4.79042
118 4G87 UD1 0.005546 0.42198 4.79042
119 1REO FAD 0.003938 0.42169 4.79042
120 2ZJ3 G6P 0.001035 0.4176 4.79042
121 4QN6 LNV 0.004914 0.41581 4.79042
122 1L2T ATP 0.001698 0.41549 4.79042
123 3DER ALA LYS 0.00204 0.40899 4.79042
124 3OZG SSI 0.00128 0.40779 4.79042
125 4BG1 OGA 0.002223 0.40764 4.79042
126 4BG1 IVL 0.002223 0.40764 4.79042
127 4LWA Q13 0.009441 0.40677 4.79042
128 1F3L SAH 0.002687 0.40648 4.79042
129 4M37 SAH 0.002242 0.4056 4.79042
130 3ZY6 GFB 0.002646 0.40492 4.79042
131 1G79 PLP 0.0114 0.40053 4.79042
132 2VBQ BSJ 0.001836 0.42887 4.84848
133 2HMT NAI 0.006374 0.42083 4.86111
134 2BLE 5GP 0.0002519 0.48644 4.90463
135 3JYN NDP 0.0008812 0.4398 4.92308
136 1WVG CXY 0.0001099 0.45677 5.01393
137 1WVG APR 0.0007647 0.43163 5.01393
138 3B20 NAD 0.003305 0.40817 5.01475
139 2C2A ADP 0.001163 0.41154 5.03876
140 1RM4 NDP 0.0003213 0.44726 5.04451
141 2QV7 ADP 0.0005613 0.42028 5.04451
142 1KDK DHT 0.0002785 0.44214 5.08475
143 3MB5 SAM 0.005107 0.42638 5.09804
144 1JA9 NDP 0.02935 0.40559 5.10949
145 3HU3 AGS 0.03113 0.40104 5.11247
146 1NUS NMN 0.01572 0.40254 5.15873
147 3B1F NAD 0.001426 0.41645 5.17241
148 1SOW NAD 0.002122 0.42392 5.18293
149 1L3I SAH 0.002628 0.4134 5.20833
150 1RZM E4P 0.000504 0.47262 5.38922
151 2PWY SAH 0.0003015 0.44285 5.38922
152 4IVG ANP 0.002837 0.43672 5.38922
153 1DSS NAD 0.0006884 0.43332 5.38922
154 1D8C GLV 0.01762 0.43178 5.38922
155 3NKS FAD 0.002392 0.42798 5.38922
156 3C2O NTM 0.01579 0.42621 5.38922
157 1LC8 33P 0.001336 0.4243 5.38922
158 3I28 34N 0.004986 0.42427 5.38922
159 4M5P FMN 0.0008533 0.4226 5.38922
160 2G86 UMP 0.006072 0.42252 5.38922
161 4LCQ URQ 0.001814 0.42238 5.38922
162 3HAZ NAD 0.002229 0.42042 5.38922
163 3L02 SN0 0.002946 0.4185 5.38922
164 3L02 CP 0.002946 0.4185 5.38922
165 3HAZ FAD 0.002992 0.41694 5.38922
166 1P7T PYR 0.02933 0.41245 5.38922
167 4RJK PYR 0.01587 0.41048 5.38922
168 1T0I FMN 0.001475 0.41005 5.38922
169 2BJK NAD 0.01683 0.40718 5.38922
170 1J5P NAD 0.004633 0.40569 5.38922
171 3T1A 5MA 0.002184 0.40401 5.38922
172 2TPL HPP 0.004392 0.40361 5.38922
173 1DLJ UGA 0.02195 0.40063 5.38922
174 2FH5 GTP 0.00125 0.41467 5.40541
175 1QX4 FAD 0.0258 0.40044 5.47445
176 1N6B DMZ 0.005687 0.41334 5.49683
177 4DEC UDP 0.0009869 0.42918 5.52326
178 4DEC 3PG 0.0009869 0.42918 5.52326
179 3EE4 MYR 0.001694 0.41189 5.57276
180 2PT9 2MH 0.003299 0.41909 5.60748
181 2PT9 S4M 0.004557 0.40302 5.60748
182 3PJU C2E 0.003652 0.40809 5.62249
183 1MXI SAH 0.00009375 0.43215 5.625
184 4COQ SAN 0.02433 0.40034 5.66802
185 3Q3C NAD 0.01517 0.40867 5.68562
186 4JWX 1N4 0.00635 0.40534 5.71429
187 1SG4 CO8 0.001562 0.42179 5.76923
188 1FMB HYB 0.0003169 0.41836 5.76923
189 3CL7 HYN 0.00424 0.40261 5.84416
190 1SS4 CIT 0.000207 0.58787 5.88235
191 1SS4 GSH 0.001105 0.50765 5.88235
192 1Y75 NAG 0.0003538 0.40634 5.9322
193 1R6D DAU 0.001307 0.45207 5.93472
194 1R6D NAD 0.00207 0.44478 5.93472
195 1SQ5 PAU 0.0003658 0.45592 5.98802
196 1T26 GBD 0.007026 0.4425 5.98802
197 1T26 NAI 0.007026 0.4425 5.98802
198 2Y7P SAL 0.001077 0.43679 5.98802
199 4IOK ADP 0.001406 0.42348 5.98802
200 3MMR ABH 0.001419 0.42173 5.98802
201 1ME8 RVP 0.01632 0.42077 5.98802
202 1X1T NAD 0.01478 0.41939 5.98802
203 2BII MTV 0.001453 0.41796 5.98802
204 4IOK XPO 0.001456 0.41793 5.98802
205 4USQ FAD 0.003563 0.41781 5.98802
206 2R40 20E 0.002634 0.41021 5.98802
207 1ECC PCP 0.002531 0.40917 5.98802
208 1P4C FMN 0.02526 0.40723 5.98802
209 4MP8 NAD 0.009488 0.40467 5.98802
210 4MP8 MLI 0.009488 0.40467 5.98802
211 3B96 MYA 0.002429 0.40435 5.98802
212 4MZ7 DGT 0.006094 0.40394 5.98802
213 4J7H TLO 0.00321 0.4019 5.98802
214 3IAE D7K 0.007667 0.40143 5.98802
215 2Z9C DTC 0.00266 0.41165 6
216 1FWY UD1 0.006474 0.40546 6.0423
217 2VAR ANP 0.0001495 0.44981 6.07029
218 2FR6 URI 0.001646 0.40836 6.16438
219 2FR6 CTN 0.002465 0.40214 6.16438
220 2Q97 ATP 0.001736 0.41336 6.20155
221 1DRV A3D 0.01134 0.41073 6.22711
222 1Y8O ADP 0.0001404 0.42252 6.25
223 3CIP ATP 0.006893 0.41505 6.25
224 4MOB COA 0.003297 0.42365 6.3253
225 2VHJ ADP 0.0003401 0.43485 6.34441
226 3L8W XAN 0.01223 0.41537 6.41892
227 4AP9 1PS 0.002147 0.40627 6.46766
228 1UXG FUM 0.001545 0.4365 6.47249
229 3CQD ATP 0.006759 0.41042 6.47249
230 2QLX RM4 0.00461 0.42891 6.48148
231 1KYQ NAD 0.0000793 0.45504 6.58683
232 1FL2 FAD 0.0007455 0.45113 6.58683
233 1H6C NDP 0.0009792 0.44306 6.58683
234 1H6C SIN 0.001129 0.44295 6.58683
235 2HGS ADP 0.0002823 0.44193 6.58683
236 3LTW HLZ 0.001894 0.43938 6.58683
237 1RYD NDP 0.001228 0.43924 6.58683
238 1MDZ DCS 0.0009163 0.43915 6.58683
239 2GYI HYA 0.006218 0.4316 6.58683
240 2NXW TPP 0.001352 0.43137 6.58683
241 1V6A TRE 0.002112 0.43084 6.58683
242 3ZOD HQE 0.001093 0.42754 6.58683
243 3ZOD FMN 0.001093 0.42754 6.58683
244 3VPD ANP 0.001203 0.41725 6.58683
245 3HY3 10F 0.001628 0.41616 6.58683
246 1UF5 CDT 0.001891 0.41591 6.58683
247 3K37 BCZ 0.02223 0.41396 6.58683
248 1H9G COA MYR 0.002652 0.41325 6.58683
249 1RRC ADP 0.0018 0.4128 6.58683
250 2ZB3 NDP 0.003564 0.41136 6.58683
251 4EPM AMP 0.002537 0.40913 6.58683
252 1BUC CAA 0.003645 0.40503 6.58683
253 1MDZ PLP 0.006954 0.40428 6.58683
254 4AAW R84 0.01968 0.40104 6.58683
255 4AXD ANP 0.01127 0.40072 6.58683
256 1R27 MGD 0.0114 0.40052 6.58683
257 3MPI GRA 0.02499 0.40047 6.58683
258 1CKM GTP 0.001544 0.41139 6.66667
259 4AT0 FAD 0.03776 0.40372 6.66667
260 1VQ2 DDN 0.0009127 0.41524 6.73575
261 3RFV NAI 0.002221 0.41762 6.74157
262 2VEZ G6P 0.001202 0.43054 6.84211
263 2VEZ ACO 0.001558 0.42485 6.84211
264 1C3V NDP 0.0002196 0.45991 6.93878
265 3ZS7 ATP 0.0002715 0.44254 7
266 1Z44 NPO 0.008175 0.44891 7.10059
267 3F3E LEU 0.0003824 0.45893 7.12909
268 1MQ0 BRD 0.001095 0.40656 7.14286
269 3IL6 B83 0.00112 0.41637 7.16511
270 1K6M AGS 0.004055 0.40001 7.17593
271 3ZPG 5GP 0.0002883 0.5032 7.18563
272 1TDF FAD 0.0004583 0.46585 7.18563
273 1SB8 UD2 0.0006745 0.46376 7.18563
274 1SB8 NAD 0.0005464 0.46376 7.18563
275 2XVE FAD 0.001529 0.45559 7.18563
276 2XVF FAD 0.0004705 0.45543 7.18563
277 1TDF NAP 0.002921 0.44921 7.18563
278 3GE7 AFQ 0.0005203 0.44855 7.18563
279 1V35 NAI 0.001478 0.44051 7.18563
280 3Q9T FAY 0.002843 0.42616 7.18563
281 2PZI AXX 0.00339 0.42573 7.18563
282 2Z9V PXM 0.002078 0.42515 7.18563
283 4C0X FMN 0.00137 0.4239 7.18563
284 4C0X AQN 0.001961 0.4239 7.18563
285 2YBQ UP2 0.002974 0.42318 7.18563
286 4DEM YS4 0.01535 0.42293 7.18563
287 1G8S MET 0.005303 0.41979 7.18563
288 4CS4 ANP 0.00441 0.41764 7.18563
289 3UH0 TSB 0.001662 0.41583 7.18563
290 1HV9 COA 0.008563 0.4144 7.18563
291 2YBQ SAH 0.001285 0.41423 7.18563
292 1HV9 UD1 0.004225 0.41253 7.18563
293 2F2U M77 0.002418 0.41184 7.18563
294 4CS4 AXZ 0.009319 0.41075 7.18563
295 1YB5 NAP 0.005483 0.41061 7.18563
296 2JL1 NAP 0.002156 0.40995 7.18563
297 1LDM NAD 0.02099 0.40945 7.18563
298 3SXF BK5 0.0169 0.40821 7.18563
299 3SQG TP7 0.002082 0.40042 7.18563
300 2IYG FMN 0.001898 0.41091 7.25806
301 1A27 NAP 0.004769 0.40796 7.26644
302 1Y9Q MED 0.001852 0.43981 7.29167
303 1CSI CMX 0.005997 0.41452 7.35632
304 1CSI OAA 0.005997 0.41452 7.35632
305 1GS5 NLG 0.001925 0.42682 7.36434
306 1GS5 ANP 0.001925 0.42682 7.36434
307 3D3W NAP 0.00227 0.42148 7.37705
308 1PR9 NAP 0.004221 0.41378 7.37705
309 1YRX FMN 0.0004129 0.42493 7.43802
310 1OLS TDP 0.01519 0.40313 7.5
311 2HGZ PBF 0.001557 0.41859 7.51634
312 3CKZ ZMR 0.004951 0.41978 7.53247
313 1I52 CTP 0.002788 0.41676 7.62712
314 1YOE RIB 0.006266 0.40215 7.76398
315 4NM5 ADP 0.0001567 0.45118 7.78443
316 1M5B BN1 0.003152 0.43964 7.78443
317 3WBF NAP 0.0007103 0.43764 7.78443
318 3WBF API 0.001259 0.43389 7.78443
319 3S7O LBV 0.001461 0.42874 7.78443
320 2GSD NAD 0.002001 0.42866 7.78443
321 1IUP ALQ 0.001396 0.42809 7.78443
322 4A6D SAM 0.000817 0.42126 7.78443
323 3QV9 QV7 0.004216 0.41816 7.78443
324 1OYB HBA 0.00198 0.41796 7.78443
325 1HYE NAP 0.001811 0.41448 7.78443
326 3ZEI AWH 0.003463 0.41183 7.78443
327 1SNY NAP 0.004319 0.40538 7.78443
328 1R89 CTP 0.002106 0.40025 7.78443
329 4D7M TDC 0.002442 0.41458 7.8341
330 1TUF AZ1 0.002353 0.412 7.8341
331 1A5Z NAD 0.01005 0.41285 7.83699
332 1XVV CCQ 0.007817 0.41 7.84314
333 1GAD NAD 0.0002932 0.44874 7.87879
334 3SJ7 NDP 0.002896 0.41475 7.93651
335 3M6W SAM 0.0008646 0.41374 7.97414
336 1O9U ADZ 0.0006451 0.48595 8
337 4CMF PXG 0.01397 0.40863 8.07453
338 1HDR NAD 0.001054 0.45321 8.19672
339 3T2W BTN 0.0005291 0.40602 8.19672
340 2NU8 COA 0.004375 0.40517 8.33333
341 1NN5 ANP 0.0007104 0.43914 8.37209
342 1NN5 2DT 0.0007104 0.43914 8.37209
343 4CKU P2F 0.001289 0.44877 8.38323
344 1B8U OAA 0.000633 0.44392 8.38323
345 3D2Y AH0 ALA FGA LYS 0.0002681 0.4363 8.38323
346 1N1G BCP 0.001339 0.43539 8.38323
347 2AQJ FAD 0.004461 0.43488 8.38323
348 2AQJ TRP 0.004286 0.43488 8.38323
349 1DR1 NAP 0.002047 0.43061 8.38323
350 1DR1 HBI 0.002047 0.43061 8.38323
351 1V9N NDP 0.001548 0.42914 8.38323
352 1R18 SAH 0.0007498 0.42657 8.38323
353 4HA6 FAD 0.004115 0.42488 8.38323
354 2DDH HXD 0.001436 0.41447 8.38323
355 2A0W DIH 0.00421 0.41443 8.38323
356 3CBG SAH 0.001019 0.41356 8.38323
357 1H2B NAJ 0.005206 0.41029 8.38323
358 2DDH FAD 0.005721 0.40872 8.38323
359 1B8U NAD 0.002138 0.40825 8.38323
360 3I8P 840 0.001299 0.40758 8.38323
361 3A1I UNU 0.004106 0.40304 8.38323
362 3LIH RAF 0.002651 0.40102 8.38323
363 1Q3Q ANP 0.001791 0.44816 8.39416
364 3VHZ L2P GLC MAN SGA 0.008513 0.42746 8.39695
365 1V2G OCA 0.001111 0.4007 8.42105
366 3S9K CIT 0.001575 0.50014 8.47458
367 1NW5 SAM 0.001907 0.40811 8.77743
368 3HF3 FMN 0.003154 0.40217 8.88252
369 2V5E SCR 0.007096 0.44284 8.91089
370 4BJZ P3A 0.02867 0.40712 8.96226
371 4BJZ FAD 0.02867 0.40712 8.96226
372 1ZK4 AC0 0.002906 0.45288 8.98204
373 1ZK4 NAP 0.002906 0.45288 8.98204
374 2RHW C0E 0.002132 0.4496 8.98204
375 1FIQ MTE 0.000617 0.44145 8.98204
376 1FIQ SAL 0.0007347 0.44145 8.98204
377 2J07 FAD 0.002112 0.44104 8.98204
378 2J07 HDF 0.002112 0.44104 8.98204
379 3PC3 P1T 0.0004476 0.43268 8.98204
380 1MOQ GLP 0.0003562 0.43193 8.98204
381 1LVL NAD 0.000473 0.43182 8.98204
382 1H82 FAD 0.005992 0.42816 8.98204
383 1H82 GZZ 0.006737 0.42816 8.98204
384 1TOI HCI 0.001742 0.42303 8.98204
385 3SIX GDP 0.000242 0.42277 8.98204
386 3IOI 1GW 0.002525 0.42105 8.98204
387 2R42 FPS 0.001019 0.41783 8.98204
388 2AMV BIN 0.01018 0.41422 8.98204
389 1LVL FAD 0.007678 0.4141 8.98204
390 4CCO OGA 0.005267 0.40866 8.98204
391 2IXB NAD 0.005657 0.40645 8.98204
392 1XMV ADP 0.01661 0.40633 8.98204
393 2IXB A2G 0.01047 0.40402 8.98204
394 1FIQ FAD 0.008606 0.40307 8.98204
395 2J5S KTA 0.002455 0.4022 8.98204
396 2XCG XCG 0.001005 0.43347 9.03846
397 2NVK FAD 0.003889 0.42392 9.22131
398 2J5V PCA 0.01293 0.42066 9.26431
399 1NHZ 486 0.003959 0.40038 9.28571
400 4FR3 0V4 0.003664 0.44443 9.40171
401 1QJC PNS 0.0009067 0.45897 9.49367
402 4IAE 1DX 0.007747 0.41864 9.52381
403 1F7K UMP 0.004232 0.40184 9.55882
404 4OYA 1VE 0.003814 0.45598 9.58084
405 4C12 ADP 0.001074 0.45555 9.58084
406 2Q1S NAI 0.0007219 0.45492 9.58084
407 4DQ2 BTX 0.0003548 0.44895 9.58084
408 1TIW FAD 0.001168 0.44124 9.58084
409 1TIW TFB 0.001168 0.44124 9.58084
410 4O8A FAD 0.00112 0.43311 9.58084
411 2IMP NAI 0.0165 0.42057 9.58084
412 1I9G SAM 0.008806 0.41349 9.58084
413 3BLI ACO 0.002094 0.41041 9.58084
414 2QQF A1R 0.002927 0.41012 9.58084
415 1C0I BE2 0.01166 0.40859 9.58084
416 1C0I FAD 0.01166 0.40859 9.58084
417 4LWM MHO 0.01503 0.40974 9.67742
418 2CFA FAD 0.003988 0.40027 9.67742
419 2YPO PHE 0.0007025 0.43933 9.74026
420 2IMF GSH 0.002086 0.41392 9.85222
421 2IMF TOM 0.002086 0.41392 9.85222
422 2X34 UQ8 0.02487 0.41129 9.94475
423 1HFS L04 0.002716 0.41984 10
424 2GJ3 FAD 0.003008 0.40104 10
425 2X32 OTP 0.03168 0.40603 10.0559
426 1LYX PGA 0.000323 0.42448 10.0806
427 2DTJ THR 0.0004724 0.40789 10.1124
428 1VDC FAD 0.001069 0.45204 10.1796
429 3BAZ NAP 0.0005716 0.4363 10.1796
430 3TKA SAM 0.000369 0.4357 10.1796
431 4NTD FAD 0.001874 0.43323 10.1796
432 1XOC VAL ASP SER LYS ASN THR SER SER TRP 0.002873 0.4281 10.1796
433 4K5S PM0 0.00667 0.42087 10.1796
434 4K5S FAD 0.002756 0.42087 10.1796
435 3WO0 ADP 0.005532 0.41272 10.1796
436 3WO0 ALA 0.005532 0.41272 10.1796
437 1F8F NAD 0.01387 0.41171 10.1796
438 2NP9 YE1 0.006016 0.40668 10.1796
439 2BNE U5P 0.006751 0.40655 10.1796
440 2BNF UTP 0.01065 0.40372 10.1796
441 2J8Z NAP 0.006132 0.40251 10.1796
442 1JIL 485 0.002897 0.40162 10.1796
443 1Q6O LG6 0.0009693 0.41201 10.1852
444 3U5S FAD 0.0007228 0.4252 10.3175
445 4Q0P 0MK 0.02256 0.42029 10.3846
446 2CSN CKI 0.0009917 0.42747 10.4377
447 1E7S NAP 0.0009826 0.43665 10.5919
448 3DAG FEG 0.001255 0.42369 10.6145
449 1I1N SAH 0.01496 0.40468 10.6195
450 1WNG SAH 0.00008849 0.45573 10.7784
451 1EP2 ORO 0.0006085 0.44729 10.7784
452 4PVV HO4 0.001034 0.4433 10.7784
453 1EP2 FMN 0.0006283 0.43808 10.7784
454 3BW2 FMN 0.001058 0.43263 10.7784
455 4IXW IXW 0.001485 0.42534 10.7784
456 2QF7 AGS 0.001712 0.42031 10.7784
457 1EP2 FAD 0.003368 0.40464 10.7784
458 4DVE BTN 0.0007405 0.40122 10.7784
459 2D37 NAD 0.004561 0.40594 10.7955
460 3UEC ALA ARG TPO LYS 0.004194 0.43078 10.9589
461 2R14 TXD 0.00632 0.40462 11.1406
462 3IIS PID 0.0123 0.4222 11.2583
463 3OND NAD 0.002775 0.43538 11.3772
464 3OND ADN 0.002775 0.43538 11.3772
465 3F81 STT 0.00755 0.4332 11.3772
466 3M0J OAF 0.001205 0.43191 11.3772
467 1YAG ATP 0.001507 0.41739 11.3772
468 4E13 NAD 0.002074 0.40872 11.3772
469 4MWV BCZ 0.00918 0.40523 11.3772
470 4A8T PAO 0.03151 0.40082 11.3772
471 2BGM NAJ 0.02004 0.40648 11.5108
472 3MBG FAD 0.004535 0.40309 11.5108
473 4R3L COA 0.001264 0.40913 11.5607
474 2Q28 ADP 0.00009012 0.45545 11.976
475 1Q0H NDP 0.001897 0.44203 11.976
476 1K97 CIR 0.009898 0.43114 11.976
477 1K97 ASP 0.009898 0.43114 11.976
478 1Q0H FOM 0.003512 0.42948 11.976
479 1D6H COA 0.003583 0.42728 11.976
480 1QF5 GDP 0.005964 0.422 11.976
481 1QF5 RPL 0.005964 0.422 11.976
482 2C31 ADP 0.01661 0.41723 11.976
483 2C31 TZD 0.01712 0.41723 11.976
484 1H6W SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 0.009173 0.41567 11.976
485 2H6T IVA VAL VAL STA ALA STA 0.0009365 0.41484 11.976
486 4IMG NGF 0.001257 0.41458 11.976
487 2DKH 3HB 0.006426 0.41334 11.976
488 2DKH FAD 0.008232 0.40266 11.976
489 3RK0 AMP 0.001001 0.40257 11.976
490 1UDB UFG 0.0006139 0.46453 12.1302
491 1UDB NAD 0.0006139 0.46453 12.1302
492 3PFG TLO 0.001127 0.44409 12.1673
493 3PFG SAM 0.001127 0.44409 12.1673
494 3ZZS TRP 0.001742 0.43097 12.3077
495 1C1L GAL BGC 0.009613 0.41436 12.4088
496 2VPR TDC 0.000304 0.42956 12.5749
497 4AQL TXC 0.0009664 0.41436 12.5749
498 1IYE PGU 0.004042 0.41199 12.5749
499 2YHW BM3 0.004319 0.40958 12.5749
500 1ULE GLA GAL NAG 0.006228 0.41673 12.6667
501 4IU0 ABH 0.0008261 0.42504 12.7273
502 3N5O GSH 0.002157 0.4042 12.766
503 3O55 FAD 0.003298 0.4082 12.8
504 3RO7 TDR 0.001435 0.4247 12.8302
505 2XKO AKG 0.000758 0.47445 13.0631
506 2XHK AKG 0.001325 0.41006 13.0631
507 1XHL NDP 0.004404 0.41184 13.1313
508 2XK9 XK9 0.0002834 0.46003 13.1737
509 1G41 ADP 0.01713 0.40794 13.1737
510 1KYV RBF 0.001835 0.40456 13.2075
511 1QO0 BMD 0.0058 0.41808 13.2653
512 1QD0 RR6 0.000254 0.44325 13.2812
513 3PVT 3HC 0.003301 0.42254 13.5135
514 2E2R 2OH 0.001054 0.43813 13.7725
515 3FC2 IBI 0.001518 0.42671 13.7725
516 2G50 PYR 0.01379 0.42244 13.7725
517 3GWT 066 0.003393 0.41487 13.7725
518 1XP8 AGS 0.0106 0.40939 13.7725
519 2EFJ SAH 0.001577 0.40689 13.7725
520 1DKU AP2 0.005468 0.40229 13.7725
521 2YC5 6BC 0.0006425 0.44768 14.3713
522 1GSA ADP 0.003733 0.4302 14.3713
523 1LCP PLU 0.002722 0.41128 14.3713
524 4TMK T5A 0.005537 0.40805 14.554
525 1EDO NAP 0.03012 0.40511 14.7541
526 2Q37 3AL 0.0007434 0.44999 14.9701
527 2QA1 FAD 0.002829 0.42286 14.9701
528 4C0C WVH 0.00676 0.41721 14.9701
529 1LTH NAD 0.01497 0.40891 14.9701
530 2AE2 NAP 0.0009257 0.44744 15
531 2AE2 PTO 0.0009257 0.44744 15
532 3LA3 2FT 0.0008267 0.4109 15.2263
533 3R35 4CO 0.003863 0.41273 15.2318
534 4WNB 4BN 0.001437 0.4083 15.5039
535 3PNL ADP 0.0002024 0.44716 15.5689
536 2C7G ODP 0.003107 0.43836 15.5689
537 1BDB NAD 0.005813 0.43657 15.5689
538 2C7G FAD 0.00366 0.43622 15.5689
539 2J7T 274 0.0008568 0.43459 15.5689
540 4G1V FAD 0.001084 0.42925 15.5689
541 1H65 GDP 0.0014 0.41487 15.5689
542 2B82 ADN 0.002069 0.40877 15.5689
543 2EWM NAD 0.007256 0.40234 15.5689
544 1JYQ MAZ PTR PTM ASN 0.00424 0.4172 15.625
545 4AF0 IMP 0.004299 0.42772 16.1677
546 1KBI PYR 0.001183 0.42627 16.1677
547 1KBI FMN 0.001183 0.42627 16.1677
548 4W6Z 8ID 0.004747 0.4153 16.1677
549 3V91 UPG 0.01149 0.4105 16.1677
550 4AF0 MOA 0.003794 0.40439 16.1677
551 1KBJ FMN 0.004857 0.40199 16.1677
552 2FYU FDN 0.0008668 0.40094 16.3636
553 4F4S EFO 0.001163 0.43543 17.1053
554 3KCC CMP 0.00001939 0.52199 17.3077
555 2YB9 HA0 0.0005016 0.44484 17.3653
556 1CBF SAH 0.001171 0.40915 17.3653
557 1EXB NDP 0.009003 0.42853 17.4757
558 4NVP 7CH 0.0000003613 0.60139 17.7034
559 1DJ9 KAM 0.001947 0.41502 17.7083
560 4AVB CMP 0.0000005619 0.56439 17.9641
561 1GRO ICT 0.007963 0.4161 17.9641
562 5RHN 8BR 0.0007165 0.41658 18.2609
563 1N9L FMN 0.0004497 0.41091 18.3486
564 3SHR CMP 0.00000003541 0.6675 18.3946
565 1RHC F42 ACN 0.0001591 0.46364 18.5629
566 4BAS GNP 0.0009946 0.42021 18.5629
567 2I4O ATP 0.0008975 0.40072 19.1617
568 4N02 FNR 0.004931 0.4286 19.7605
569 1NE6 SP1 0.00000004017 0.63533 19.788
570 4BMO FMN 0.004151 0.40451 20.3593
571 4NE2 SH2 0.001939 0.42919 20.9581
572 4NE2 ADP 0.003046 0.41921 20.9581
573 3DGB MUC 0.001304 0.41694 20.9581
574 2P8O BVA 0.001474 0.40791 21.374
575 3ZV6 4HB 0.0001458 0.48135 21.5569
576 3ZV6 NAD 0.004059 0.42319 21.5569
577 3QXC ATP 0.003687 0.40642 21.5569
578 2FOI JPA 0.00002918 0.44705 21.6667
579 1NNU NAD 0.01725 0.42074 21.6667
580 1NNU TCT 0.01983 0.41813 21.6667
581 3BL6 FMC 0.002482 0.40204 22.1739
582 1CX4 CMP 0.0000008056 0.58089 23.2787
583 1Z45 NAD 0.001113 0.43179 23.9521
584 1Z45 UPG 0.002567 0.40151 23.9521
585 1T0S BML 0.001237 0.46302 24.4186
586 1KOL NAD 0.0042 0.41736 26.3473
587 3I54 CMP 0.00000928 0.53068 26.9076
588 3OF1 CMP 0.000000004 0.71258 27.2358
589 3I59 N6R 0.000009005 0.53694 27.3092
590 3I59 N6S 0.000009841 0.53521 27.3092
591 2D0V PQQ 0.0008215 0.42118 27.7778
592 3OCP CMP 0.0000000146 0.68581 28.0576
593 2PTZ PAH 0.0001247 0.44306 28.1437
594 4G28 0W8 0.0003107 0.408 28.4314
595 2WUF KEM 0.0009065 0.42543 31.1377
596 4OFG PCG 0.0002134 0.51536 31.25
597 4GQB 0XU 0.0005716 0.46669 31.8182
598 2YVF FAD 0.004853 0.43407 32.9341
599 2YVF NAD 0.005517 0.43244 32.9341
600 3L0E G58 0.0001838 0.45626 33.3333
601 4NAT ADP 0.009813 0.43131 35.625
602 3PNA CMP 0.000000003173 0.72984 36.3636
603 4KU7 PCG 0.0000001155 0.63317 36.6013
604 1C4U IH1 0.0007986 0.42057 42.8571
Pocket No.: 3; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 3cf6.bio2) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 3CF6; Ligand: SP1; Similar sites found: 15
This union binding pocket(no: 4) in the query (biounit: 3cf6.bio2) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5DA3 58V 0.008198 0.41207 4.15094
2 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.02709 0.41463 5.38922
3 2JDR L20 0.02709 0.41463 5.38922
4 1RE8 BD2 0.01989 0.41447 5.98802
5 4CRL C1I 0.02154 0.40203 7.18563
6 5IH9 6BF 0.01816 0.4078 8.38323
7 2O3Z AI7 0.04819 0.41062 9.5941
8 5N53 8NB 0.009085 0.41982 11.976
9 4N9I PCG 0.00002291 0.55899 21.4286
10 5KBF CMP 0.0000005079 0.57689 22.9236
11 5KJZ PCG 0.00000003919 0.6358 28.6667
12 5H5O PCG 0.00000549 0.53204 30.2326
13 5C8W PCG 0.000000000588 0.65264 31.4685
14 5BV6 35G 0.00000008532 0.62769 34.8684
15 5JAX 6J7 0.0000003474 0.59385 41.4815
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