Receptor
PDB id Resolution Class Description Source Keywords
3DCQ 1.8 Å NON-ENZYME: BINDING LECB (PA-LII) IN COMPLEX WITH THE SYNTHETIC LIGAND 2G0 PSEUDOMONAS AERUGINOSA LECTIN CARBOHYDRATE SUGAR BINDING PROTEIN
Ref.: INHIBITION AND DISPERSION OF PSEUDOMONAS AERUGINOSA BIOFILMS BY GLYCOPEPTIDE DENDRIMERS TARGETING THE FUCOSE-SPECIFIC LECTIN LECB. CHEM.BIOL. V. 15 1249 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
2G0 A:201;
B:201;
C:201;
D:201;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
ic50 = 5.94 uM
543.653 C25 H45 N5 O8 C[C@H...
CA A:115;
A:116;
B:115;
B:116;
C:115;
C:116;
D:115;
D:116;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1W8H 1.75 Å NON-ENZYME: BINDING STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) COMPLEXED WITH LEWISA TRISACCHARIDE PSEUDOMONAS AERUGINOSA SUGAR BINDING PROTEIN LECTIN SUGAR LEWIS A CYSTIC FIBROS
Ref.: STRUCTURAL BASIS FOR THE INTERACTION BETWEEN HUMAN OLIGOSACCHARIDES AND THE BACTERIAL LECTIN PA-IIL OF PSEUDOMONAS AERUGINOSA. BIOCHEM.J. V. 389 325 2005
Members (22)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 473 families.
1 2JDH Kd = 310 nM FUC NAG TA5 n/a n/a
2 5A3O Kd = 18 uM MMA DH6 n/a n/a
3 1OXC - FUC C6 H12 O5 C[C@H]1[C@....
4 3ZDV Kd = 3.3 uM MMA F1A n/a n/a
5 2JDP Kd = 0.25 uM MFU C7 H14 O5 C[C@H]1[C@....
6 1W8H Ka = 47000000000 M^-1 FUC NDG GAL n/a n/a
7 1UZV Kd = 0.6667 uM FUC C6 H12 O5 C[C@H]1[C@....
8 2BP6 - GXL C6 H12 O6 C([C@H]1[C....
9 2JDY Kd = 42.9 uM MMA C7 H14 O6 CO[C@@H]1[....
10 3DCQ ic50 = 5.94 uM 2G0 C25 H45 N5 O8 C[C@H]1[C@....
11 1W8F Ka = 15600000000 M^-1 FUC BGC GAL n/a n/a
12 1OUR - MAN C6 H12 O6 C([C@@H]1[....
13 2JDK Kd = 290 nM FUC NAG T45 n/a n/a
14 2VUC - FUC C6 H12 O5 C[C@H]1[C@....
15 2BOJ Kd = 1.7 uM ARW C6 H12 O5 CO[C@H]1[C....
16 1OVP - BDF C6 H12 O6 C1[C@H]([C....
17 1GZT ic50 = 0.25 mM FUC C6 H12 O5 C[C@H]1[C@....
18 4UT5 - GAL NAG GAL FUC n/a n/a
19 2JDN Kd = 2.78 uM MMA C7 H14 O6 CO[C@@H]1[....
20 1OVS - MAN MAN n/a n/a
21 2JDU Kd = 0.19 uM MFU C7 H14 O5 C[C@H]1[C@....
22 2JDM Kd = 3.96 uM MFU C7 H14 O5 C[C@H]1[C@....
70% Homology Family (25)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 355 families.
1 2JDH Kd = 310 nM FUC NAG TA5 n/a n/a
2 5A3O Kd = 18 uM MMA DH6 n/a n/a
3 1OXC - FUC C6 H12 O5 C[C@H]1[C@....
4 3ZDV Kd = 3.3 uM MMA F1A n/a n/a
5 2JDP Kd = 0.25 uM MFU C7 H14 O5 C[C@H]1[C@....
6 1W8H Ka = 47000000000 M^-1 FUC NDG GAL n/a n/a
7 1UZV Kd = 0.6667 uM FUC C6 H12 O5 C[C@H]1[C@....
8 2BP6 - GXL C6 H12 O6 C([C@H]1[C....
9 2JDY Kd = 42.9 uM MMA C7 H14 O6 CO[C@@H]1[....
10 3DCQ ic50 = 5.94 uM 2G0 C25 H45 N5 O8 C[C@H]1[C@....
11 1W8F Ka = 15600000000 M^-1 FUC BGC GAL n/a n/a
12 1OUR - MAN C6 H12 O6 C([C@@H]1[....
13 2JDK Kd = 290 nM FUC NAG T45 n/a n/a
14 2VUC - FUC C6 H12 O5 C[C@H]1[C@....
15 2BOJ Kd = 1.7 uM ARW C6 H12 O5 CO[C@H]1[C....
16 1OVP - BDF C6 H12 O6 C1[C@H]([C....
17 1GZT ic50 = 0.25 mM FUC C6 H12 O5 C[C@H]1[C@....
18 4UT5 - GAL NAG GAL FUC n/a n/a
19 2JDN Kd = 2.78 uM MMA C7 H14 O6 CO[C@@H]1[....
20 1OVS - MAN MAN n/a n/a
21 2JDU Kd = 0.19 uM MFU C7 H14 O5 C[C@H]1[C@....
22 2JDM Kd = 3.96 uM MFU C7 H14 O5 C[C@H]1[C@....
23 2BV4 ic50 = 600 uM MMA C7 H14 O6 CO[C@@H]1[....
24 2BOI ic50 = 48 uM MFU C7 H14 O5 C[C@H]1[C@....
25 1UQX - MMA C7 H14 O6 CO[C@@H]1[....
50% Homology Family (28)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 272 families.
1 2JDH Kd = 310 nM FUC NAG TA5 n/a n/a
2 5A3O Kd = 18 uM MMA DH6 n/a n/a
3 1OXC - FUC C6 H12 O5 C[C@H]1[C@....
4 3ZDV Kd = 3.3 uM MMA F1A n/a n/a
5 2JDP Kd = 0.25 uM MFU C7 H14 O5 C[C@H]1[C@....
6 1W8H Ka = 47000000000 M^-1 FUC NDG GAL n/a n/a
7 1UZV Kd = 0.6667 uM FUC C6 H12 O5 C[C@H]1[C@....
8 2BP6 - GXL C6 H12 O6 C([C@H]1[C....
9 2JDY Kd = 42.9 uM MMA C7 H14 O6 CO[C@@H]1[....
10 3DCQ ic50 = 5.94 uM 2G0 C25 H45 N5 O8 C[C@H]1[C@....
11 1W8F Ka = 15600000000 M^-1 FUC BGC GAL n/a n/a
12 1OUR - MAN C6 H12 O6 C([C@@H]1[....
13 2JDK Kd = 290 nM FUC NAG T45 n/a n/a
14 2VUC - FUC C6 H12 O5 C[C@H]1[C@....
15 2BOJ Kd = 1.7 uM ARW C6 H12 O5 CO[C@H]1[C....
16 1OVP - BDF C6 H12 O6 C1[C@H]([C....
17 1GZT ic50 = 0.25 mM FUC C6 H12 O5 C[C@H]1[C@....
18 4UT5 - GAL NAG GAL FUC n/a n/a
19 2JDN Kd = 2.78 uM MMA C7 H14 O6 CO[C@@H]1[....
20 1OVS - MAN MAN n/a n/a
21 2JDU Kd = 0.19 uM MFU C7 H14 O5 C[C@H]1[C@....
22 2JDM Kd = 3.96 uM MFU C7 H14 O5 C[C@H]1[C@....
23 2BV4 ic50 = 600 uM MMA C7 H14 O6 CO[C@@H]1[....
24 2BOI ic50 = 48 uM MFU C7 H14 O5 C[C@H]1[C@....
25 1UQX - MMA C7 H14 O6 CO[C@@H]1[....
26 2WR9 Kd = 2.6 uM MAN MAN n/a n/a
27 2VNV Kd = 2.75 uM MMA C7 H14 O6 CO[C@@H]1[....
28 2WRA Kd = 26.9 uM MAN MAN MAN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 2G0; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 2G0 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
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