Receptor
PDB id Resolution Class Description Source Keywords
3FRQ 1.76 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURE OF THE MACROLIDE BIOSENSOR PROTEIN, MPHR(A), WITH ERYTHROMCYIN ESCHERICHIA COLI MACROLIDE ANTIBIOTIC. REPRESSOR BIOSENSOR ERYTHROMYCIN STRPTOMYCES NATURAL PRODUCTS BIOSYNTHESIS DNA-BINDING TRANSCRIPTION TRANSCRIPTION REGULATION DNA BINDING PROTEI
Ref.: STRUCTURE AND FUNCTION OF THE MACROLIDE BIOSENSOR P MPHR(A), WITH AND WITHOUT ERYTHROMYCIN J.MOL.BIOL. V. 387 1250 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:198;
B:200;
 Invalid;
Invalid;
 none;
none;
 submit data
35.453 Cl [Cl-]
ERY A:195;
B:195;
 Valid;
Valid;
 none;
none;
 submit data
733.927 C37 H67 N O13 CC[C@...
GOL A:196;
A:197;
B:196;
B:197;
B:198;
B:199;
 Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
none;
none;
 submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3FRQ 1.76 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURE OF THE MACROLIDE BIOSENSOR PROTEIN, MPHR(A), WITH ERYTHROMCYIN ESCHERICHIA COLI MACROLIDE ANTIBIOTIC. REPRESSOR BIOSENSOR ERYTHROMYCIN STRPTOMYCES NATURAL PRODUCTS BIOSYNTHESIS DNA-BINDING TRANSCRIPTION TRANSCRIPTION REGULATION DNA BINDING PROTEI
Ref.: STRUCTURE AND FUNCTION OF THE MACROLIDE BIOSENSOR P MPHR(A), WITH AND WITHOUT ERYTHROMYCIN J.MOL.BIOL. V. 387 1250 2009
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 308 families.
1 3FRQ - ERY C37 H67 N O13 CC[C@@H]1[....
2 6U18 - CTY C38 H69 N O13 CC[C@@H]1[....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 266 families.
1 3FRQ - ERY C37 H67 N O13 CC[C@@H]1[....
2 6U18 - CTY C38 H69 N O13 CC[C@@H]1[....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 220 families.
1 3FRQ - ERY C37 H67 N O13 CC[C@@H]1[....
2 6U18 - CTY C38 H69 N O13 CC[C@@H]1[....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ERY; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 ERY 1 1
2 CTY 0.831776 0.981481
3 ERB 0.790909 0.981481
4 ZIT 0.737288 0.898305
5 EY5 0.669565 1
Similar Ligands (3D)
Ligand no: 1; Ligand: ERY; Similar ligands found: 1
No: Ligand Similarity coefficient
1 ZIO 0.8592
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3FRQ; Ligand: ERY; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3frq.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 3FRQ; Ligand: ERY; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 3frq.bio1) has 23 residues
No: Leader PDB Ligand Sequence Similarity
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