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Receptor
PDB id Resolution Class Description Source Keywords
3HB5 2 Å EC: 1.1.1.62 BINARY AND TERNARY CRYSTAL STRUCTURES OF A NOVEL INHIBITOR O HSD TYPE 1: A LEAD COMPOUND FOR BREAST CANCER THERAPY HOMO SAPIENS 17BETA-HSD1 CYTOPLASM LIPID SYNTHESIS NADP OXIDOREDUCTASPOLYMORPHISM STEROID BIOSYNTHESIS
Ref.: BINARY AND TERNARY CRYSTAL STRUCTURE ANALYSES OF A INHIBITOR WITH 17BETA-HSD TYPE 1: A LEAD COMPOUND F CANCER THERAPY. BIOCHEM.J. V. 424 357 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
E2B X:700;
Valid;
none;
Ki = 0.9 nM
405.529 C26 H31 N O3 C[C@]...
NAP X:360;
Valid;
none;
submit data
743.405 C21 H28 N7 O17 P3 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3HB5 2 Å EC: 1.1.1.62 BINARY AND TERNARY CRYSTAL STRUCTURES OF A NOVEL INHIBITOR O HSD TYPE 1: A LEAD COMPOUND FOR BREAST CANCER THERAPY HOMO SAPIENS 17BETA-HSD1 CYTOPLASM LIPID SYNTHESIS NADP OXIDOREDUCTASPOLYMORPHISM STEROID BIOSYNTHESIS
Ref.: BINARY AND TERNARY CRYSTAL STRUCTURE ANALYSES OF A INHIBITOR WITH 17BETA-HSD TYPE 1: A LEAD COMPOUND F CANCER THERAPY. BIOCHEM.J. V. 424 357 2009
Members (12)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 1JTV - TES C19 H28 O2 C[C@]12CC[....
2 1QYX - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
3 1DHT - DHT C19 H30 O2 C[C@]12CCC....
4 3HB5 Ki = 0.9 nM E2B C26 H31 N O3 C[C@]12CC[....
5 3HB4 - E2B C26 H31 N O3 C[C@]12CC[....
6 1I5R Ki = 3 nM HYC C37 H51 N5 O7 C[C@]12CC[....
7 1IOL - EST C18 H24 O2 C[C@]12CC[....
8 1FDT - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
9 1QYW - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 3KLM - DHT C19 H30 O2 C[C@]12CCC....
11 1QYV - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
12 1FDS - EST C18 H24 O2 C[C@]12CC[....
70% Homology Family (13)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1A27 - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
2 1JTV - TES C19 H28 O2 C[C@]12CC[....
3 1QYX - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
4 1DHT - DHT C19 H30 O2 C[C@]12CCC....
5 3HB5 Ki = 0.9 nM E2B C26 H31 N O3 C[C@]12CC[....
6 3HB4 - E2B C26 H31 N O3 C[C@]12CC[....
7 1I5R Ki = 3 nM HYC C37 H51 N5 O7 C[C@]12CC[....
8 1IOL - EST C18 H24 O2 C[C@]12CC[....
9 1FDT - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 1QYW - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
11 3KLM - DHT C19 H30 O2 C[C@]12CCC....
12 1QYV - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
13 1FDS - EST C18 H24 O2 C[C@]12CC[....
50% Homology Family (13)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1A27 - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
2 1JTV - TES C19 H28 O2 C[C@]12CC[....
3 1QYX - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
4 1DHT - DHT C19 H30 O2 C[C@]12CCC....
5 3HB5 Ki = 0.9 nM E2B C26 H31 N O3 C[C@]12CC[....
6 3HB4 - E2B C26 H31 N O3 C[C@]12CC[....
7 1I5R Ki = 3 nM HYC C37 H51 N5 O7 C[C@]12CC[....
8 1IOL - EST C18 H24 O2 C[C@]12CC[....
9 1FDT - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 1QYW - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
11 3KLM - DHT C19 H30 O2 C[C@]12CCC....
12 1QYV - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
13 1FDS - EST C18 H24 O2 C[C@]12CC[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: E2B; Similar ligands found: 10
No: Ligand ECFP6 Tc MDL keys Tc
1 E2B 1 1
2 6WM 0.715909 0.767442
3 7FQ 0.663043 0.73913
4 ESL 0.550562 0.680851
5 ESZ 0.538462 0.659574
6 EST 0.467391 0.688889
7 J3Z 0.446809 0.681818
8 HE7 0.435185 0.708333
9 6WW 0.428571 0.615385
10 6WV 0.415094 0.729167
Ligand no: 2; Ligand: NAP; Similar ligands found: 123
No: Ligand ECFP6 Tc MDL keys Tc
1 NAP 1 1
2 NA0 0.881356 0.986301
3 TAP 0.872881 0.934211
4 NDO 0.840336 0.972603
5 NAD 0.811966 0.986111
6 N01 0.733871 0.958904
7 A3D 0.712 0.972603
8 NBP 0.707692 0.935065
9 NHD 0.68254 0.958904
10 NJP 0.661417 0.972973
11 NFD 0.658915 0.934211
12 NXX 0.619048 0.959459
13 DND 0.619048 0.959459
14 AMP NAD 0.606061 0.958904
15 ZID 0.605839 0.972603
16 NAQ 0.59854 0.922078
17 ATR 0.59292 0.917808
18 NAE 0.591241 0.946667
19 NDE 0.58042 0.986301
20 A22 0.571429 0.958904
21 NAJ 0.567164 0.986111
22 A2R 0.563025 0.932432
23 NDC 0.561644 0.922078
24 NA7 0.552846 0.907895
25 ODP 0.551471 0.935065
26 A2P 0.539823 0.930556
27 8ID 0.537313 0.910256
28 NPW 0.525547 0.8875
29 NZQ 0.521739 0.910256
30 CNA 0.521739 0.959459
31 NDP 0.514493 0.922078
32 PO4 PO4 A A A A PO4 0.503937 0.930556
33 1DG 0.503401 0.922078
34 DG1 0.503401 0.922078
35 TXP 0.5 0.922078
36 NMN AMP PO4 0.492958 0.921053
37 XNP 0.492958 0.875
38 25L 0.492308 0.958904
39 25A 0.492063 0.972222
40 NMN 0.486726 0.888889
41 NGD 0.485714 0.935065
42 9JJ 0.481707 0.8875
43 2AM 0.477876 0.891892
44 ADP 0.458333 0.945205
45 PAP 0.451613 0.931507
46 A2D 0.445378 0.945205
47 AN2 0.442623 0.932432
48 7L1 0.441558 0.777778
49 ADP PO3 0.44 0.944444
50 SAP 0.44 0.896104
51 AGS 0.44 0.896104
52 M33 0.439024 0.906667
53 AR6 AR6 0.438849 0.945205
54 BA3 0.438017 0.945205
55 OAD 0.43609 0.92
56 ADP BMA 0.43609 0.92
57 DQV 0.435714 0.958904
58 HEJ 0.435484 0.945205
59 ATP 0.435484 0.945205
60 OOB 0.435115 0.958904
61 B4P 0.434426 0.945205
62 AP5 0.434426 0.945205
63 GAP 0.433071 0.92
64 0WD 0.432432 0.922078
65 2A5 0.432 0.87013
66 5FA 0.432 0.945205
67 AQP 0.432 0.945205
68 AT4 0.430894 0.907895
69 00A 0.428571 0.909091
70 DAL AMP 0.427481 0.932432
71 CA0 0.427419 0.92
72 ADP ALF 0.426357 0.871795
73 ALF ADP 0.426357 0.871795
74 9X8 0.425373 0.871795
75 ACP 0.424 0.92
76 NAJ PZO 0.423841 0.897436
77 9SN 0.423358 0.897436
78 ADP VO4 0.423077 0.932432
79 VO4 ADP 0.423077 0.932432
80 WAQ 0.422222 0.884615
81 V3L 0.421875 0.945205
82 ACQ 0.421875 0.92
83 ADQ 0.421053 0.92
84 AR6 0.420635 0.918919
85 APR 0.420635 0.918919
86 ATP A A A 0.42029 0.958333
87 CO7 0.419753 0.786517
88 3OD 0.419118 0.92
89 1ZZ 0.419118 0.841463
90 DLL 0.41791 0.958904
91 AD9 0.417323 0.92
92 NAX 0.416667 0.875
93 OVE 0.416667 0.857143
94 MYR AMP 0.416058 0.841463
95 AV2 0.415385 0.868421
96 A3P 0.414634 0.944444
97 NNR 0.414414 0.72973
98 OMR 0.413793 0.831325
99 6YZ 0.412214 0.92
100 ANP 0.410853 0.92
101 A1R 0.410448 0.860759
102 ABM 0.409836 0.893333
103 A 0.408333 0.944444
104 AMP 0.408333 0.944444
105 SON 0.408 0.933333
106 PPS 0.407692 0.829268
107 5AL 0.407692 0.932432
108 NAI 0.406897 0.909091
109 7D3 0.406504 0.857143
110 ADX 0.404762 0.829268
111 ATF 0.40458 0.907895
112 3UK 0.404412 0.945946
113 TYR AMP 0.404255 0.921053
114 AMP DBH 0.404255 0.894737
115 139 0.402685 0.875
116 50T 0.401575 0.906667
117 SRP 0.401515 0.907895
118 A A 0.40146 0.972222
119 B5V 0.40146 0.933333
120 A3R 0.4 0.860759
121 3AM 0.4 0.90411
122 B5M 0.4 0.921053
123 FA5 0.4 0.933333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3HB5; Ligand: E2B; Similar sites found with APoc: 193
This union binding pocket(no: 1) in the query (biounit: 3hb5.bio1) has 26 residues
No: Leader PDB Ligand Sequence Similarity
1 1OW4 2AN None
2 4WG0 CHD None
3 1TW4 CHD None
4 3HYW DCQ 1.52905
5 5ULJ 0WD 1.83486
6 1L5Y BEF 1.93548
7 4XDA ADP 1.94175
8 5OSW DIU 2.14067
9 1Q19 SSC 2.14067
10 4AR8 IP8 GLY PRO ALA 2.14067
11 2UW1 GVM 2.14067
12 3O01 DXC 2.27273
13 4MGA 27L 2.35294
14 1FAO 4IP 2.38095
15 4TV1 36M 2.39044
16 2Q8G AZX 2.44648
17 4N6H EJ4 2.44648
18 1KEW TYD 2.44648
19 4RPM HXC 2.44648
20 1KEW NAD 2.44648
21 5CQG 55C 2.44648
22 5LX9 OLB 2.46479
23 2IOR ADP 2.55319
24 5LKC FUC GLA A2G 2.5974
25 4Q0A GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 2.64901
26 3E70 GDP 2.75229
27 4RZB NFQ 2.75229
28 4GPS CIT 2.75229
29 5Y02 HBX 2.80374
30 5XWV 8H6 2.82258
31 3RET SAL 2.9703
32 3RET PYR 2.9703
33 2C1P FNZ 3.0581
34 4N49 MGT 3.0581
35 5DYO FLU 3.0581
36 5V4R MGT 3.08642
37 1NU4 MLA 3.09278
38 3G3N TC8 3.14465
39 3PPQ CHT 3.21543
40 1R6N 434 3.31754
41 1XMY ROL 3.36391
42 1XM4 PIL 3.36391
43 1R6D DAU 3.36391
44 1XMU ROF 3.36391
45 4A59 AMP 3.36391
46 3W6X HZP 3.49345
47 5L7G LYS SER LEU LEU GLN GLN LEU LEU THR GLU 3.66972
48 5CX6 CDP 3.66972
49 5HCN DAO 3.83142
50 4WGF HX2 3.90244
51 3TDC 0EU 3.97554
52 5W7B MYR 4.25532
53 1XL8 152 4.28135
54 4PIV 2W4 4.28135
55 6AP6 TLF 4.28135
56 1OC2 TDX 4.28135
57 1OC2 NAD 4.28135
58 3CHT 4NB 4.28135
59 4M3P HCS 4.28135
60 4O4Z N2O 4.54545
61 5FQK 6NT 4.58716
62 1D6H COA 4.58716
63 3B12 FAH 4.60526
64 5C9J DAO 4.62633
65 1Q6O LG6 4.62963
66 3KP6 SAL 4.63576
67 2GWH PCI 4.69799
68 1RV1 IMZ 4.70588
69 1SW1 PBE 4.72727
70 2WH8 II2 4.84262
71 4J7U YTZ 4.86111
72 4J7U NAP 4.86111
73 3QP8 HL0 4.8913
74 2W90 6PG 4.89297
75 3KO0 TFP 4.9505
76 1OAA OAA 5.01931
77 5N17 8FK 5.07246
78 5CHR 4NC 5.10949
79 2C29 DQH 5.19878
80 2C29 NAP 5.19878
81 2ZBA ZBA 5.19878
82 3EXS 5RP 5.42986
83 6DW2 HD4 5.48523
84 2BCG GER 5.50459
85 1YFS ALA 5.50459
86 2YN4 39J 5.9322
87 5KAU RHQ 6.06061
88 2FKA BEF 6.20155
89 5X3R 7Y3 6.34146
90 5A86 D7E 6.36943
91 3ROE THM 6.41509
92 4K55 H6P 6.45161
93 3L8G GMB 6.95187
94 3G58 988 7.03364
95 3G4G D71 7.03364
96 3RMK BML 7.22892
97 1T0S BML 7.33945
98 5C1P ADP 7.51634
99 4RJD TFP 7.57576
100 6FMC DUE 7.64526
101 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 7.82609
102 4GDX GLU 7.95107
103 4QBK 3NZ 8.24742
104 4YSX E23 8.25688
105 4WCX MET 8.25688
106 1KJ1 MAN 8.25688
107 1GQ2 OXL 8.56269
108 1OFZ FUL 8.8685
109 2QGI UDP 8.87097
110 1J78 VDY 9.17431
111 1N8V BDD 9.82143
112 4UCC ZKW 9.87124
113 2NNJ 225 10.0917
114 4UDK BMA 10.3976
115 1QKQ MAN 10.5634
116 4RQL SNE 10.7034
117 4WQ2 3SU 11.5607
118 5C1M OLC 12
119 6GNO XDI 12.5926
120 5ZCO CHD 13.0435
121 5Z84 CHD 13.0435
122 5W97 CHD 13.0435
123 2Y69 CHD 13.75
124 4IXW IXW 14.1732
125 1DTL BEP 14.2857
126 2GN4 UD1 14.3731
127 3O5N BR0 16.0714
128 4D42 W0I 17.0213
129 4D42 NAP 17.0213
130 5MWE TCE 18.5185
131 2BGM MAX 22.3022
132 1HDC CBO 23.2283
133 4OHU NAD 23.8754
134 4OHU 2TK 23.8754
135 3RJ5 NAD 25.5906
136 3O03 GCO 25.7732
137 4KWI 1TJ 25.8555
138 4KWI NAP 25.8555
139 3JQ9 AX1 26.7361
140 5JDI 6JO 26.7361
141 5K6A 6QT 26.7361
142 5JCJ 6JM 26.7361
143 4CM8 IZ9 26.7361
144 5JDC 6JP 26.7361
145 4CME KTZ 26.7361
146 4CMI M4V 26.7361
147 3JQB DX6 26.7361
148 4CM9 YGL 26.7361
149 3BMQ AX5 26.7361
150 3BMO AX4 26.7361
151 3CH6 NAP 27.2727
152 3CH6 311 27.2727
153 1XSE NDP 27.7966
154 3ZV6 NAD 28.8256
155 3ZV6 4HB 28.8256
156 1G0N NDP 29.3286
157 1G0N PHH 29.3286
158 4K26 SFF 30.0725
159 5EPO TUD 30.5344
160 2DTX BMA 31.0606
161 2AE2 PTO 33.0769
162 2AE2 NAP 33.0769
163 5OJI ISN 33.0769
164 5OJI NAP 33.0769
165 4OSP 2V4 33.0798
166 5GWT SIN 34.1727
167 3VZS CAA 34.6304
168 3VZS NAP 34.6304
169 1JA9 PYQ 34.6715
170 1XHL TNE 34.6801
171 5B4T 3HR 35
172 5B4T NAD 35
173 5O42 NAD 35.0365
174 5O42 9JW 35.0365
175 5O42 BGC 35.0365
176 2WSB NAD 35.0394
177 5FFF NAP 35.4086
178 5FFF 5XC 35.4086
179 1U7T TDT 35.6322
180 2BD0 BIO 36.0656
181 3AY6 BGC 36.4312
182 3AY6 NAI 36.4312
183 1ZK4 NAP 36.6534
184 1ZK4 AC0 36.6534
185 6CI9 F3V 36.6795
186 2CFC KPC 37.2
187 2JAP J01 37.6518
188 2RH4 EMO 38.2671
189 4JP3 CIT 39.3305
190 4YAG NAI 41.5225
191 4NBU CAA 41.6
192 4ITU 1HS 42.7509
193 3AI3 SOL 43.7262
Pocket No.: 2; Query (leader) PDB : 3HB5; Ligand: E2B; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 3hb5.bio1) has 26 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 3HB5; Ligand: NAP; Similar sites found with APoc: 886
This union binding pocket(no: 3) in the query (biounit: 3hb5.bio1) has 49 residues
No: Leader PDB Ligand Sequence Similarity
1 1LSS NAD None
2 3A27 SAM 1.10294
3 4GKV NAD 1.22324
4 3S1S SAH 1.22324
5 3UWB BB2 1.2987
6 1P77 ATR 1.47059
7 3T7S SAM 1.49254
8 1N7G GDR 1.52905
9 1N7G NDP 1.52905
10 2IXB NAD 1.52905
11 1YS4 NAP 1.52905
12 3HYW DCQ 1.52905
13 1ZH8 NAP 1.52905
14 2IXB A2G 1.52905
15 6FDF SAH 1.52905
16 3OQJ 3CX 1.55642
17 1SQF SAM 1.6317
18 4FGC PQ0 1.81818
19 1V35 NAI 1.83486
20 6BII NAP 1.83486
21 3WMX NAD 1.83486
22 4DCM SAM 1.83486
23 5JJR SAH 1.83486
24 5AOV NAP 1.83486
25 1LVL NAD 1.83486
26 3TLJ SAH 1.83486
27 4P87 4NP 1.83486
28 1P31 EPU 1.83486
29 4XDZ NDP 1.83486
30 4Y4V DAL 1.83486
31 5E4R NAP 1.83486
32 1P3D UMA 1.83486
33 3Q60 ATP 1.83486
34 1OJJ GLC GAL 1.83486
35 1OJK GLC BGC 1.83486
36 4TSK NDP 1.83486
37 1VJT NAD 1.83486
38 5T9E NAP 1.84502
39 5D4V SAH 1.86567
40 3LKZ SFG 1.86916
41 4CJX NAP 1.88088
42 3OA2 NAD 1.88679
43 5TC4 NAD 1.89873
44 4OM8 NAD 1.94175
45 4XDA ADP 1.94175
46 3MAG SAH 1.9544
47 5X9D 80F 1.97368
48 1IV2 CDP 1.97368
49 6AA8 NAD 1.98676
50 1D7O NAD 2.0202
51 1D7O TCL 2.0202
52 3MCT SAH 2.0202
53 3E3U NVC 2.03046
54 2B1N LYS ALA SER VAL GLY 2.03252
55 1UY4 XYP XYP XYP XYP 2.06897
56 5YJF 8WO 2.11268
57 2I7C AAT 2.12014
58 9LDT NAD 2.14067
59 9LDB NAD 2.14067
60 3A06 NDP 2.14067
61 3M6W SAM 2.14067
62 3BAZ NAP 2.14067
63 4C4A SAH 2.14067
64 2DBZ NAP 2.14067
65 5OSW DIU 2.14067
66 3KB6 NAD 2.14067
67 5F8F SFG 2.14067
68 1LJ8 NAD 2.14067
69 4R5M NAP 2.14067
70 5X62 SAH 2.14067
71 1M2W NAD 2.14067
72 3A06 FOM 2.14067
73 4R5M 4NO 2.14067
74 1OBB NAD 2.14067
75 3UDZ ADP 2.14067
76 2ALG DAO 2.17391
77 3C1O NAP 2.18069
78 1F06 NDP 2.1875
79 2PX8 SAH 2.23048
80 2UYQ SAM 2.25806
81 5W3Y ACO 2.27273
82 4NEC SAH 2.27273
83 2AG8 NAP 2.28137
84 2A14 SAH 2.28137
85 1O6Z NAD 2.31023
86 5N6C NAD 2.33333
87 2PV7 NAD 2.34899
88 4MGA 27L 2.35294
89 4J3L AJ5 2.38095
90 3EWR APR 2.38095
91 2JL1 NAP 2.43902
92 1KEW NAD 2.44648
93 1KEW TYD 2.44648
94 5MPT SAH 2.44648
95 1J0X NAD 2.44648
96 5OCM NAP 2.44648
97 2Q1S NAI 2.44648
98 3I6I NDP 2.44648
99 3H5N ATP 2.44648
100 4XFR CIT 2.44648
101 1O0S NAI 2.44648
102 1OFL ASG GCD 2.44648
103 1LLU NAD 2.44648
104 2JJQ SAH 2.44648
105 2EG5 SAH 2.44648
106 4RSL FAD 2.44648
107 2GSD NAD 2.44648
108 2ZXI FAD 2.44648
109 5LX9 OLB 2.46479
110 2IYL GDP 2.46479
111 2Z9I GLY ALA THR VAL 2.46914
112 1F3L SAH 2.49221
113 5LOG SAH 2.57511
114 1NNU NAD 2.62009
115 1NNU TCT 2.62009
116 5CG1 NAD BBN 2.62295
117 2E0N SAH 2.7027
118 2PWY SAH 2.71318
119 2WHL MAN BMA BMA 2.72109
120 3MB5 SAM 2.7451
121 5MSO NAP 2.75229
122 1V6A TRE 2.75229
123 5JAQ NAI 2.75229
124 3CIF NAD 2.75229
125 1CF2 NAP 2.75229
126 6C4N NAP 2.75229
127 2D2I NAP 2.75229
128 5MDH NAD 2.75229
129 3CIF G3H 2.75229
130 5NUF NAD 2.75229
131 2Q1W NAD 2.75229
132 3E70 GDP 2.75229
133 1DJN ADP 2.75229
134 5U5G NAP 2.75229
135 5NUE NAD 2.75229
136 1VKO NAD 2.75229
137 4RZB NFQ 2.75229
138 4MDH NAD 2.75229
139 1PS9 NAP 2.75229
140 2ZWI C5P 2.75229
141 3SSO SAH 2.75229
142 5K7U SAM 2.75229
143 5J75 6GQ 2.75229
144 6GKV SAH 2.75229
145 2IV3 UDP 2.75229
146 5X68 FAD 2.75229
147 1KYZ SAH 2.75229
148 4A0S NAP 2.75229
149 2GZ3 NAP 2.75229
150 3JWH SAH 2.76498
151 1J5P NAD 2.7668
152 4RDH AMP 2.77778
153 4RDI ATP 2.77778
154 5Y02 HBX 2.80374
155 1ZQ9 SAM 2.80702
156 5XWV 8H6 2.82258
157 5XWV NDP 2.82258
158 2VDV SAM 2.84553
159 6ECU SAH 2.8481
160 6ECW SAH 2.85714
161 1X7D NAD 2.85714
162 1QAN SAH 2.86885
163 5E9W SAH 2.88462
164 3EGI ADP 2.91262
165 4YMH SAH 2.91667
166 2BOS GLA GAL GLC 2.94118
167 2BOS GLA GAL 2.94118
168 2BOS GLA GAL GLC NBU 2.94118
169 3B20 NAD 2.94985
170 3B1J NAD 2.94985
171 2DC1 NAD 2.9661
172 3V1Y NAD 2.96736
173 3RET SAL 2.9703
174 3RET PYR 2.9703
175 1GR0 NAD 2.99728
176 5IL1 SAM 3
177 1DSS NAD 3.003
178 1B8U NAD 3.03951
179 2EV9 NAP 3.04183
180 2EV9 SKM 3.04183
181 3ABI NAD 3.0581
182 4N49 SAM 3.0581
183 5CAE COA 3.0581
184 2GVC FAD 3.0581
185 2GV8 FAD 3.0581
186 1KEV NDP 3.0581
187 1VQW FAD 3.0581
188 1VM6 NAD 3.07018
189 5V4R MGT 3.08642
190 1NU4 MLA 3.09278
191 5UAV NDP 3.10559
192 5UAV TFB 3.10559
193 1T26 GBD 3.10559
194 1T26 NAI 3.10559
195 2A92 NAI 3.11526
196 1P0F NAP 3.21716
197 3U40 ADN 3.30579
198 1R6N 434 3.31754
199 5T9F TYR 3.32103
200 5T9F NAP 3.32103
201 1R6D DAU 3.36391
202 1R6D NAD 3.36391
203 2VYN NAD 3.36391
204 6D6Y SAH 3.36391
205 2PZM UDP 3.36391
206 2PZM NAD 3.36391
207 1GAD NAD 3.36391
208 1PL6 NAD 3.36391
209 1K3T BRZ 3.36391
210 5X20 NAD 3.36391
211 1SAY PYR 3.36391
212 1PL6 572 3.36391
213 1XMY ROL 3.36391
214 1D1T NAD 3.36391
215 5CWA 0GA 3.36391
216 1H2B NAJ 3.36391
217 1XM4 PIL 3.36391
218 4OOE NDP 3.36391
219 4OOE FOM 3.36391
220 5MBC FMN 3.36391
221 3GLC R5P 3.38983
222 1JG3 ADN 3.40426
223 3ENV ABF 3.40426
224 3H8V ATP 3.42466
225 1QG6 NAD 3.44828
226 1QG6 TCL 3.44828
227 3B1F NAD 3.44828
228 2QBU SAH 3.44828
229 3GWN FAD 3.50877
230 5W7K SAH 3.52564
231 4E13 NAD 3.53357
232 2D2F ADP 3.6
233 3QV1 NAD 3.65854
234 1GY8 NAD 3.66972
235 4Z0H NAD 3.66972
236 4EUE NAI 3.66972
237 3L9W AMP 3.66972
238 3ULK NDP 3.66972
239 6C4M NAP 3.66972
240 2YX1 SFG 3.66972
241 4UCI SAM 3.66972
242 3L9W GSH 3.66972
243 3GMB FAD 3.66972
244 5DN9 NAD 3.66972
245 1SC6 NAD 3.66972
246 6GZD LCI 3.66972
247 3PT9 SAH 3.66972
248 2CVQ NDP 3.66972
249 6A3J NAI 3.66972
250 3CGB FAD 3.66972
251 2O4C NAD 3.66972
252 3IHG FAD 3.66972
253 3FUU ADN 3.69004
254 1OMO NAD 3.72671
255 1LTH NAD 3.76176
256 1VL0 NAI 3.76712
257 5XNC MTA 3.77358
258 3KIF GDL 3.77358
259 5Z2F NAP 3.77358
260 5HCN DAO 3.83142
261 4QTU SAM 3.84615
262 5XDT GDP 3.8961
263 4WGF HX2 3.90244
264 4FK7 P34 3.93013
265 5BSH PRO 3.97112
266 5THY SAH 3.97554
267 1MUU NAD 3.97554
268 2B4R AES 3.97554
269 2B4R NAD 3.97554
270 5THZ SAH 3.97554
271 5A1T NAI 3.97554
272 3GU3 SAH 3.97554
273 1U1I NAD 3.97554
274 2V7B BEZ 3.97554
275 5A1T OXM 3.97554
276 4LWP SAH 3.97554
277 1V59 NAD 3.97554
278 1X14 NAD 3.97554
279 4XQC NAD 3.97554
280 4XQC 13D 3.97554
281 1UP7 NAD 3.97554
282 5DOZ NDP 3.97554
283 5KVS NAP 3.97554
284 2QA1 FAD 3.97554
285 3O7W SAM 4.08163
286 3A4V PYR 4.10095
287 3A4V NAD 4.10095
288 5CUQ NSC 4.11985
289 4XUC 43G 4.12844
290 4XUC SAM 4.12844
291 2BKA NDP 4.13223
292 4ZRN NAD 4.16667
293 4ZRN UPG 4.16667
294 2VT3 ATP 4.18605
295 5AYV NAP 4.20712
296 4F07 FAD 4.21053
297 1JAY NAP 4.24528
298 2AHR NAP 4.2471
299 2RI1 GLP 4.25532
300 5W7B MYR 4.25532
301 2DT5 NAD 4.2654
302 4PIV NDP 4.28135
303 1OC2 TDX 4.28135
304 1OC2 NAD 4.28135
305 3H9E NAD 4.28135
306 6CEP NAD 4.28135
307 4GLL NAD 4.28135
308 1EBF NAD 4.28135
309 6CEP OXM 4.28135
310 4LHD GLY 4.28135
311 3GCZ SAM 4.28135
312 5MW4 5JU 4.28135
313 2GLX NDP 4.28135
314 4PIV 2W4 4.28135
315 1UKG MMA 4.28135
316 2DKH FAD 4.28135
317 5YF1 SFG 4.28135
318 2NXE SAM 4.33071
319 5OOH NAP 4.36893
320 5OOH 9ZZ 4.36893
321 1LDN NAD 4.43038
322 5BW4 SAM 4.49438
323 4D3F NAP 4.51613
324 4O4Z N2O 4.54545
325 1ORR NAD 4.58716
326 5LD5 NAD 4.58716
327 1E5Q NDP 4.58716
328 5FQK 6NT 4.58716
329 4ZGS NAD 4.58716
330 2V6G NAP 4.58716
331 1F8G NAD 4.58716
332 6A0S NDP 4.58716
333 6A0S HSE 4.58716
334 5H81 NAP 4.58716
335 1CDO NAD 4.58716
336 5Z20 NAI 4.58716
337 1NM5 NAD 4.58716
338 1L7E NAI 4.58716
339 5FI3 NAP 4.58716
340 5NMX FAD 4.58716
341 5C9J DAO 4.62633
342 4J4H 1J1 4.6332
343 3KP6 SAL 4.63576
344 3A25 SAM 4.65116
345 2F1K NAP 4.6595
346 2GWH PCI 4.69799
347 1RV1 IMZ 4.70588
348 4UP3 NDP 4.77707
349 5D9X GSH 4.78261
350 3G89 SAM 4.81928
351 4ZVV NAD 4.81928
352 4ZVV GN0 4.81928
353 2I3G NAP 4.82955
354 4PLT NAI 4.83384
355 4PLT OXM 4.83384
356 5HW4 SAM 4.83871
357 4J7U YTZ 4.86111
358 4J7U NAP 4.86111
359 1LUA NAP 4.87805
360 1NVT NAP 4.87805
361 2X6T NAP 4.89297
362 4KOA NDP 4.89297
363 2YYY NAP 4.89297
364 5X2N ALA 4.89297
365 4RLQ 3SK 4.89297
366 4RQU NAD 4.89297
367 3VSE SAH 4.89297
368 3TWO NDP 4.89297
369 2VJM COA 4.89297
370 4X9M FAD 4.89297
371 2W90 6PG 4.89297
372 5YSQ INS 4.8951
373 2P41 SAH 4.91803
374 3WBF NAP 4.91803
375 3WBF API 4.91803
376 1Z6Z NAP 4.96454
377 5ZI9 FLC 5
378 3G2O SAM 5.01672
379 1OAA OAA 5.01931
380 3WV8 ATP 5.04587
381 2CDU ADP 5.0885
382 2CDU FAD 5.0885
383 3OFK SAH 5.09259
384 5CHR 4NC 5.10949
385 1KYQ NAD 5.10949
386 2Q0L NAP 5.14469
387 1EQ2 NAP 5.16129
388 2OOR NAD 5.17241
389 5HZ9 5M8 5.18518
390 2C29 NAP 5.19878
391 2C29 DQH 5.19878
392 4U7W NDP 5.19878
393 1CER NAD 5.19878
394 4PLG NAI 5.19878
395 4PLG OXM 5.19878
396 4M37 SAH 5.19878
397 1J49 NAD 5.19878
398 4DPL NAP 5.19878
399 2VHW NAI 5.19878
400 5W7R SAH 5.19878
401 3M89 GSP 5.19878
402 1L1E SAH 5.22648
403 1EJ4 M7G 5.26316
404 6AZQ C5J 5.34351
405 2BKX F6R 5.3719
406 4D79 ATP 5.43478
407 3EVG SAH 5.45455
408 1E6E FAD 5.46875
409 4PVD NDP 5.50459
410 1RM4 NDP 5.50459
411 3FSY SCA 5.50459
412 2BCG GER 5.50459
413 5KOK SAH 5.50459
414 4K5S FAD 5.50459
415 6AIN FAD 5.50459
416 5FUB SAH 5.50459
417 2FR1 NDP 5.55556
418 5ZHO A2G GLA FUC 5.55556
419 6DWI HD4 5.5794
420 5ULP KB1 5.59701
421 5K4W THR 5.60748
422 5K4W NAI 5.60748
423 1SB8 UD2 5.68182
424 1SB8 NAD 5.68182
425 5KKA 6V0 5.76923
426 1I2B NAD 5.8104
427 1I2B USQ 5.8104
428 1I2B UPG 5.8104
429 5ERG SAM 5.8104
430 3VPH NAD 5.8104
431 1SOW NAD 5.8104
432 3VPH OXM 5.8104
433 1BW9 NAD 5.8104
434 1C1X NAD 5.8104
435 4XZ3 COA 5.8104
436 5A9A UTP 5.8104
437 4XDY NAI 5.8104
438 1BXG NAD 5.8104
439 4TXI FAD 5.8104
440 1BXG HCI 5.8104
441 2BRY FAD 5.8104
442 5YPU ATP 5.8104
443 2FF6 ATP 5.8104
444 2RGJ FAD 5.8104
445 4FZV SAM 5.84958
446 5FTW SAH 5.85938
447 1WP4 NDP 5.88235
448 5XVH NAP 5.88235
449 5YEC ATP 5.88235
450 1E7S NAP 5.919
451 3I53 SAH 6.0241
452 3CBG SAH 6.03448
453 3LU1 NAD 6.11621
454 5ZEC NAP 6.11621
455 6DNT NAD 6.11621
456 1YKF NAP 6.11621
457 1E3I CXF 6.11621
458 1FP2 SAH 6.11621
459 5E72 SAM 6.11621
460 1RJD SAM 6.11621
461 5ETJ IM5 6.11621
462 3VC1 SAH 6.11621
463 1C3V NDP 6.12245
464 2OL1 UMP 6.12245
465 1R18 SAH 6.1674
466 2FKA BEF 6.20155
467 3BXO SAM 6.27615
468 5A86 D7E 6.36943
469 3ROE THM 6.41509
470 5YSN 5AD 6.42202
471 3LST SAH 6.42202
472 2GN2 C5P 6.43275
473 5Y8L NAD 6.44068
474 5Y8L HUI 6.44068
475 2AOT SAH 6.50685
476 2XVM SAH 6.53266
477 1TIQ COA 6.66667
478 1HYE NAP 6.70927
479 2Q46 NAP 6.71937
480 5Z75 NAD 6.72783
481 4E5N NAD 6.72783
482 3X0D SAH 6.72783
483 3WLE NAD 6.72783
484 1HKU NAD 6.72783
485 4KP7 1UQ 6.72783
486 3WQQ IB3 6.72783
487 3WQQ NDP 6.72783
488 2ZWA SAH 6.72783
489 2D3M COA 6.72783
490 5ZZ6 ADP 6.73077
491 5ZZ6 NAD 6.73077
492 2YY7 NAD 6.73077
493 3FIU POP 6.82731
494 3MQ2 SAH 6.88073
495 2HMT NAI 6.94444
496 1NVM NAD 6.95652
497 2PXX SAH 6.97674
498 3OJF IMJ 7.00389
499 3OJF NDP 7.00389
500 1NYT NAP 7.01107
501 1HDG NAD 7.03364
502 5DNK SAH 7.03364
503 3G58 988 7.03364
504 3G4G D71 7.03364
505 5OJL TXP 7.04698
506 5N5D SAM 7.07965
507 3L4S NAD 7.14286
508 3L4S 3PG 7.14286
509 3DUW SAH 7.17489
510 5YRV 5AD 7.29927
511 5N2I NAP 7.32759
512 5EES NAP 7.33945
513 5Y77 FAD 7.33945
514 1FP1 SAH 7.33945
515 4II2 ATP 7.36196
516 3SJK LYS PRO VAL LEU ARG THR ALA 7.36842
517 1HYH NAD 7.44337
518 4UHF BUA 7.44681
519 2G5C NAD 7.47331
520 3OIG NAD 7.5188
521 3ORF NAD 7.56972
522 4RJD TFP 7.57576
523 3KIV ACA 7.59494
524 1BXK NAD 7.64526
525 1TI7 NAP 7.64526
526 2VUT NAD 7.64526
527 2Y6Q FAD 7.64526
528 2AJH MET 7.65306
529 3A4T SFG 7.66423
530 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 7.82609
531 1A5Z NAD 7.83699
532 5JE8 NAD 7.94702
533 1RKX NAD 7.95107
534 2JHP SAH 7.95107
535 4KIB SAH 7.95107
536 1U8X NAD 7.95107
537 1NPD NAD 7.98611
538 5ZW3 SAH 8
539 1MV8 NAD 8.02752
540 1G60 SAM 8.07692
541 4IMG NGF 8.19113
542 2XYQ SAH 8.19672
543 1RPN NDP 8.25688
544 5UR0 NAD 8.25688
545 1X87 NAD 8.25688
546 1PZG A3D 8.25688
547 1WVG APR 8.25688
548 2CUN 3PG 8.25688
549 4KRG SAH 8.25688
550 5JGL SAM 8.3045
551 4YCA NDP 8.5034
552 1GQ2 NAP 8.56269
553 2YVJ NAI 8.56269
554 1R37 NAD 8.64553
555 1FMB HYB 8.65385
556 1DRV A3D 8.79121
557 5ZI2 NAD 8.8685
558 5ZI2 ADP 8.8685
559 1Z82 NDP 8.8685
560 1JE1 GMP 8.8983
561 5E8J SAH 9.09091
562 5WP4 SAH 9.17431
563 5W7M SAH 9.29487
564 5F5N NAD 9.34256
565 2WA2 SAM 9.42029
566 3ICS ADP 9.48012
567 3ICT ADP 9.48012
568 3GFB NAD 9.48012
569 3EBL GA4 9.48012
570 1YKJ FAD 9.48012
571 4M38 SAH 9.52381
572 1DCP HBI 9.61539
573 1TO9 HMH 9.61539
574 1GV0 NAD 9.67742
575 1GUZ NAD 9.67742
576 3DMH SAM 9.71129
577 3DMH GMP 9.71129
578 3OJO NAD 9.74478
579 3LCC SAH 9.78593
580 2DFV NAD 9.78593
581 1N8V BDD 9.82143
582 1I36 NAP 9.84848
583 4UCC ZKW 9.87124
584 5KUT GDP 10.0529
585 5DF1 NAP 10.0917
586 5DF1 58X 10.0917
587 6BWL NAD 10.0917
588 5Z21 NAI 10.0917
589 1GZ4 ATP 10.0917
590 2GCG NDP 10.0917
591 2PK3 A2R 10.2804
592 1UXG FUM 10.356
593 1UXG NAD 10.356
594 6EL3 NAP 10.3976
595 4L8V NAP 10.3976
596 3N8K D1X 10.4651
597 4TQG NDP 10.8359
598 3NOJ PYR 10.9244
599 5WP5 SAH 11.0092
600 1YB5 NAP 11.1111
601 5EIN NAP 11.1111
602 5J6Y BGC 11.1702
603 5J6Y GLC 11.1702
604 1LDM NAD 11.315
605 6F5Z SAH 11.4754
606 3K7S R52 11.7318
607 2EXX NAP 11.7647
608 4R1S NAP 11.9266
609 5A04 BGC 11.9266
610 5A04 NDP 11.9266
611 4XB2 NDP 11.9403
612 4XB2 HSE 11.9403
613 5C1M OLC 12
614 1WDK NAD 12.2324
615 4JK3 NAD 12.3552
616 2CVZ NDP 12.5382
617 5I7S NAD 12.6812
618 5I7S E9P 12.6812
619 3GGO ENO 12.7389
620 3GGO NAI 12.7389
621 2HJR APR 12.8049
622 4J1Q NDP 12.844
623 3S5W FAD 12.844
624 1SJN DUP 12.9412
625 3VYW SAM 12.987
626 5ZCO CHD 13.0435
627 5Z84 CHD 13.0435
628 1O94 ADP 13.125
629 5BJX NAD 13.1498
630 5BJX UDP 13.1498
631 1PJS NAD 13.1498
632 4KRI SAH 13.1498
633 3FZG SAM 13.4557
634 3KO8 NAD 13.4615
635 2RIF AMP 13.4752
636 2Y69 CHD 13.75
637 3MZS HC9 13.7615
638 5GM1 SAH 13.8047
639 4BVA NDP 14.0673
640 4IXW IXW 14.1732
641 2GN4 UD1 14.3731
642 2GN4 NDP 14.3731
643 5Y1G AKB 14.3731
644 5Y1G NAD 14.3731
645 1EJ0 SAM 14.4444
646 2WYV NAD 14.5594
647 4HI0 GDP 14.5729
648 2C5A GDC 14.6789
649 2C5A NAD 14.6789
650 5L53 NAP 14.8148
651 5A96 GTP 14.8594
652 1EYQ NAR 15.3153
653 6F9Q NAD 15.4412
654 1VI2 NAD 15.6667
655 5IN4 6CK 15.9021
656 5IN4 GDP 15.9021
657 4G5H UD7 15.9021
658 4G5H NAP 15.9021
659 5IN4 NAP 15.9021
660 1HDR NAD 15.9836
661 1ZBQ NAD 16.208
662 1UDB UFG 16.208
663 1UDB NAD 16.208
664 1Z45 NAD 16.208
665 4HXY NDP 16.6667
666 1Y8Q ATP 16.8196
667 4D42 NAP 17.0213
668 4D42 W0I 17.0213
669 2HK9 ATR 17.0909
670 2HK9 NAP 17.0909
671 6C4T NA7 17.1254
672 1I9G SAM 17.1429
673 2IZ1 ATR 17.4312
674 1YJQ NAP 17.4917
675 5L95 AMP 17.5
676 3H4V DVP 17.7083
677 3H4V NAP 17.7083
678 5L4L 7OX 17.7632
679 5L4L NAP 17.7632
680 4OBW SAM 17.8988
681 5T46 MGP 18.1818
682 1Y1P NMN AMP PO4 18.6544
683 4O1M NAD 18.7302
684 1EZ4 NAD 18.8679
685 3GEG NAD 19.0283
686 1APZ ASP 19.1358
687 2GAG FOA 19.1919
688 3RFV NAI 19.8502
689 3RFV 15L 19.8502
690 4Q9N NAI 20.1835
691 4Q9N 0WE 20.1835
692 3RZ3 U94 20.2186
693 5L4S 6KX 20.7547
694 5L4S NAP 20.7547
695 5MLR GRQ 20.7951
696 5MLR NAP 20.7951
697 5FA5 MTA 21.7125
698 4GQB 0XU 21.7125
699 2BGM NAJ 22.3022
700 2BGM MAX 22.3022
701 1HDC CBO 23.2283
702 2PD4 NAD 23.2727
703 2PD4 DCN 23.2727
704 4ZU3 4SD 23.348
705 4Y9D NAI 23.6066
706 3WXB NDP 23.6559
707 4OHU NAD 23.8754
708 4OHU 2TK 23.8754
709 5O98 NAP 24.2902
710 1FK8 NAD 24.5136
711 1N5D NDP 25
712 3O26 NDP 25.0765
713 3RJ5 NAD 25.5906
714 1EK6 NAI 25.6881
715 1EK6 UPG 25.6881
716 3O03 NAP 25.7732
717 4KWI 1TJ 25.8555
718 4KWI NAP 25.8555
719 1W73 NAP 26.4901
720 1W8D NAP 26.4901
721 5JDI NAP 26.7361
722 4CM8 NAP 26.7361
723 5JCJ NAP 26.7361
724 5JDC NAP 26.7361
725 5K6A NAP 26.7361
726 4CM9 NAP 26.7361
727 4CLR NAP 26.7361
728 4CMI NAP 26.7361
729 3BMN NAP 26.7361
730 3JQ9 NAP 26.7361
731 3BMO NAP 26.7361
732 3JQF NAP 26.7361
733 3BMQ NAP 26.7361
734 4CM4 NAP 26.7361
735 3JQA NAP 26.7361
736 3JQG NAP 26.7361
737 3JQ7 NAP 26.7361
738 4CME KTZ 26.7361
739 4CME NAP 26.7361
740 5JDI 6JO 26.7361
741 3JQB NAP 26.7361
742 3JQ8 DX3 26.7361
743 4CLO NAP 26.7361
744 3JQB DX6 26.7361
745 3JQ9 AX1 26.7361
746 3JQ8 NAP 26.7361
747 4CM9 YGL 26.7361
748 3JQ7 DX2 26.7361
749 4CM8 IZ9 26.7361
750 5JDC 6JP 26.7361
751 5K6A 6QT 26.7361
752 4CMI M4V 26.7361
753 5JCJ 6JM 26.7361
754 3BMQ AX5 26.7361
755 3CH6 NAP 27.2727
756 3CH6 311 27.2727
757 1O5I NAD 27.3092
758 1WMA AB3 27.5362
759 1WMA NDP 27.5362
760 1XSE NDP 27.7966
761 1W6U NAP 27.8146
762 1W6U HXC 27.8146
763 3V1U NAD 28.1346
764 2VZ0 NAP 28.3582
765 2VZ0 D64 28.3582
766 2WD7 NAP 28.3582
767 2WD7 VGD 28.3582
768 1NFQ NAI 28.4615
769 3ZV6 4HB 28.8256
770 3ZV6 NAD 28.8256
771 1G0N PHH 29.3286
772 1G0N NDP 29.3286
773 1YXM ADE 30.033
774 1AE1 NAP 30.0366
775 4K26 SFF 30.0725
776 2B4Q NAP 30.0725
777 4K26 NDP 30.0725
778 5G4L NDP 30.4196
779 5EPO TUD 30.5344
780 5EPO NAP 30.5344
781 2DKN NAI 30.5882
782 5OVL NAP 30.6667
783 1EDO NAP 30.7377
784 5THQ NDP 30.8824
785 5WUW NAP 31.0105
786 4FC7 NAP 31.0469
787 4FC7 COA 31.0469
788 2DTX BMA 31.0606
789 5FEU NAP 31.2715
790 3U4C NDP 31.3167
791 5EJ2 NAD 31.4935
792 1MXH DHF 31.5217
793 1MXH NAP 31.5217
794 5GT9 NAP 31.5589
795 5YSS NAD 32.0312
796 3OID NDP 32.1705
797 3OID TCL 32.1705
798 2AE2 PTO 33.0769
799 2AE2 NAP 33.0769
800 5OJI NAP 33.0769
801 5OJI ISN 33.0769
802 4OSP NAP 33.0798
803 4OSP