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Receptor
PDB id Resolution Class Description Source Keywords
3LKZ 2 Å EC: 2.-.-.- STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBI OF FLAVIVIRUS METHYLTRANSFERASE WEST NILE VIRUS WEST NILE VIRUS FLAVIVIRUS METHYLTRANSFERASE INHIBITOR PNUCLEOTIDE-BINDING RNA REPLICATION VIRAL PROTEIN
Ref.: STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBIC POCKET OF FLAVIVIRUS METHYLTRANSFERASE. J.BIOL.CHEM. V. 285 32586 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:302;
B:302;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SFG A:301;
B:301;
Valid;
Valid;
none;
none;
submit data
381.387 C15 H23 N7 O5 c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3LKZ 2 Å EC: 2.-.-.- STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBI OF FLAVIVIRUS METHYLTRANSFERASE WEST NILE VIRUS WEST NILE VIRUS FLAVIVIRUS METHYLTRANSFERASE INHIBITOR PNUCLEOTIDE-BINDING RNA REPLICATION VIRAL PROTEIN
Ref.: STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBIC POCKET OF FLAVIVIRUS METHYLTRANSFERASE. J.BIOL.CHEM. V. 285 32586 2010
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 269 families.
1 3LKZ - SFG C15 H23 N7 O5 c1nc(c2c(n....
70% Homology Family (33)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 237 families.
1 2P3L - G3A C20 H27 N10 O17 P3 c1nc(c2c(n....
2 2P41 - G1G C22 H32 N10 O18 P3 Cn1c[n+](c....
3 1L9K - SAH C14 H20 N6 O5 S c1nc(c2c(n....
4 5M5B - SAM C15 H22 N6 O5 S C[S@@+](CC....
5 5GOZ - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
6 5GP1 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
7 5KQR - SAM C15 H22 N6 O5 S C[S@@+](CC....
8 5NJU - SAH C14 H20 N6 O5 S c1nc(c2c(n....
9 5ULP Kd = 24.3 uM KB1 C21 H26 F N7 O5 c1cc(ccc1C....
10 5MRK - SFG C15 H23 N7 O5 c1nc(c2c(n....
11 5NJV - SAM C15 H22 N6 O5 S C[S@@+](CC....
12 5WXB - SAH C14 H20 N6 O5 S c1nc(c2c(n....
13 5KQS - SAM C15 H22 N6 O5 S C[S@@+](CC....
14 3LKZ - SFG C15 H23 N7 O5 c1nc(c2c(n....
15 3EVG - SAH C14 H20 N6 O5 S c1nc(c2c(n....
16 2PX5 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
17 2PXA - SAH C14 H20 N6 O5 S c1nc(c2c(n....
18 2PX8 - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
19 2PX2 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
20 2PX4 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
21 5E9Q - SAM C15 H22 N6 O5 S C[S@@+](CC....
22 5EHG - 5O0 C20 H16 Cl N3 O6 S c1cc(cc(c1....
23 5EKX - 2CQ C7 H9 Cl N2 Cc1cc(c(cc....
24 4R8S - SFG C15 H23 N7 O5 c1nc(c2c(n....
25 4CTJ - 3A9 C9 H8 O3 c1cc2c(cc1....
26 4CTK - SAM C15 H22 N6 O5 S C[S@@+](CC....
27 5EC8 - 5LP C15 H14 Cl N3 O3 Cc1ccc(c(c....
28 5EIW - X0V C7 H7 F3 N2 c1cc(c(cc1....
29 3P8Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
30 5CUQ ic50 = 7.7 uM NSC C21 H20 N6 O Cc1cc(c2cc....
31 5EIF - 4M0 C8 H9 N O2 Cc1ccc(c(c....
32 5EHI - 5O3 C20 H17 Cl N4 O5 S c1cc(cc(c1....
33 3P97 - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (47)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3EVA - SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 3EVC - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 3EVF - SAH C14 H20 N6 O5 S c1nc(c2c(n....
4 3EVB - SAH C14 H20 N6 O5 S c1nc(c2c(n....
5 3EVD - SAH C14 H20 N6 O5 S c1nc(c2c(n....
6 3EVE - SAH C14 H20 N6 O5 S c1nc(c2c(n....
7 3ELU - SAM C15 H22 N6 O5 S C[S@@+](CC....
8 3ELW - SAM C15 H22 N6 O5 S C[S@@+](CC....
9 3EMD - SFG C15 H23 N7 O5 c1nc(c2c(n....
10 3ELD - SFG C15 H23 N7 O5 c1nc(c2c(n....
11 3ELY - SAH C14 H20 N6 O5 S c1nc(c2c(n....
12 3EMB - SAM C15 H22 N6 O5 S C[S@@+](CC....
13 2P3L - G3A C20 H27 N10 O17 P3 c1nc(c2c(n....
14 2P41 - G1G C22 H32 N10 O18 P3 Cn1c[n+](c....
15 1L9K - SAH C14 H20 N6 O5 S c1nc(c2c(n....
16 5M5B - SAM C15 H22 N6 O5 S C[S@@+](CC....
17 5GOZ - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
18 5GP1 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
19 5KQR - SAM C15 H22 N6 O5 S C[S@@+](CC....
20 5NJU - SAH C14 H20 N6 O5 S c1nc(c2c(n....
21 5ULP Kd = 24.3 uM KB1 C21 H26 F N7 O5 c1cc(ccc1C....
22 5MRK - SFG C15 H23 N7 O5 c1nc(c2c(n....
23 5NJV - SAM C15 H22 N6 O5 S C[S@@+](CC....
24 5WXB - SAH C14 H20 N6 O5 S c1nc(c2c(n....
25 5KQS - SAM C15 H22 N6 O5 S C[S@@+](CC....
26 3LKZ - SFG C15 H23 N7 O5 c1nc(c2c(n....
27 3EVG - SAH C14 H20 N6 O5 S c1nc(c2c(n....
28 2PX5 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
29 2PXA - SAH C14 H20 N6 O5 S c1nc(c2c(n....
30 2PX8 - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
31 2PX2 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
32 2PX4 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
33 5E9Q - SAM C15 H22 N6 O5 S C[S@@+](CC....
34 5EHG - 5O0 C20 H16 Cl N3 O6 S c1cc(cc(c1....
35 5EKX - 2CQ C7 H9 Cl N2 Cc1cc(c(cc....
36 4R8S - SFG C15 H23 N7 O5 c1nc(c2c(n....
37 4CTJ - 3A9 C9 H8 O3 c1cc2c(cc1....
38 4CTK - SAM C15 H22 N6 O5 S C[S@@+](CC....
39 5EC8 - 5LP C15 H14 Cl N3 O3 Cc1ccc(c(c....
40 5EIW - X0V C7 H7 F3 N2 c1cc(c(cc1....
41 3P8Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
42 5CUQ ic50 = 7.7 uM NSC C21 H20 N6 O Cc1cc(c2cc....
43 5EIF - 4M0 C8 H9 N O2 Cc1ccc(c(c....
44 5EHI - 5O3 C20 H17 Cl N4 O5 S c1cc(cc(c1....
45 3P97 - SAM C15 H22 N6 O5 S C[S@@+](CC....
46 3GCZ - SAM C15 H22 N6 O5 S C[S@@+](CC....
47 2WA2 - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SFG; Similar ligands found: 231
No: Ligand ECFP6 Tc MDL keys Tc
1 SFG 1 1
2 0UM 0.689655 0.887324
3 SAI 0.654762 0.940298
4 SA8 0.642857 0.9
5 SAH 0.635294 0.954545
6 EEM 0.62069 0.875
7 5X8 0.619048 0.924242
8 S7M 0.606742 0.875
9 ADN 0.597222 0.850746
10 RAB 0.597222 0.850746
11 XYA 0.597222 0.850746
12 5CD 0.594595 0.863636
13 5N5 0.581081 0.850746
14 62X 0.574468 0.84
15 A4D 0.573333 0.850746
16 K15 0.568421 0.863014
17 DTA 0.564103 0.84058
18 6RE 0.560976 0.833333
19 SAM 0.555556 0.875
20 EP4 0.551282 0.802817
21 KB1 0.55102 0.887324
22 M2T 0.544304 0.780822
23 SMM 0.537634 0.84
24 MTA 0.5375 0.826087
25 AMP 0.53012 0.77027
26 A 0.53012 0.77027
27 ZAS 0.53012 0.816901
28 LMS 0.53012 0.678571
29 J7C 0.529412 0.84507
30 3DH 0.52439 0.826087
31 GJV 0.523256 0.821918
32 SON 0.522727 0.813333
33 0XU 0.522222 0.938462
34 SRP 0.521277 0.813333
35 SSA 0.521277 0.697674
36 AOC 0.517647 0.826087
37 CA0 0.516854 0.776316
38 5AL 0.516129 0.786667
39 DSZ 0.515464 0.717647
40 AMO 0.515464 0.813333
41 GSU 0.515152 0.738095
42 KH3 0.514286 0.851351
43 ABM 0.511628 0.75
44 A2D 0.511628 0.75
45 A3N 0.511628 0.814286
46 A5A 0.510638 0.682353
47 5CA 0.510417 0.697674
48 SRA 0.505882 0.730769
49 S4M 0.505747 0.792208
50 A3S 0.505618 0.895522
51 A7D 0.505618 0.882353
52 AN2 0.505618 0.74026
53 GAP 0.505376 0.776316
54 54H 0.5 0.666667
55 M33 0.5 0.74026
56 LAD 0.5 0.818182
57 A12 0.5 0.766234
58 ADX 0.5 0.678571
59 Y3J 0.5 0.80303
60 DSH 0.5 0.871429
61 LSS 0.5 0.681818
62 KAA 0.5 0.712644
63 VMS 0.5 0.666667
64 AP2 0.5 0.766234
65 BA3 0.5 0.75
66 SXZ 0.49505 0.875
67 ME8 0.49505 0.775
68 AHX 0.494949 0.759494
69 53H 0.494845 0.659091
70 DAL AMP 0.494845 0.786667
71 TSB 0.494845 0.674419
72 G5A 0.494624 0.697674
73 50T 0.494505 0.74026
74 ADP 0.494382 0.75
75 5AS 0.494382 0.640449
76 AP5 0.494382 0.75
77 B4P 0.494382 0.75
78 F0P 0.490909 0.9
79 GEK 0.489796 0.913043
80 8QN 0.489796 0.786667
81 AT4 0.488889 0.721519
82 5AD 0.486842 0.828125
83 PAJ 0.484848 0.728395
84 52H 0.484536 0.659091
85 AU1 0.483516 0.730769
86 MAO 0.483146 0.782051
87 A3G 0.482759 0.882353
88 NEC 0.482759 0.797101
89 3AM 0.482353 0.733333
90 YAP 0.480769 0.802632
91 7D7 0.480519 0.794118
92 NB8 0.480392 0.782051
93 TXA 0.480392 0.766234
94 NVA LMS 0.48 0.693182
95 ATF 0.479167 0.721519
96 HEJ 0.478261 0.75
97 A3T 0.478261 0.852941
98 ACP 0.478261 0.753247
99 ATP 0.478261 0.75
100 7MD 0.476636 0.775
101 YSA 0.47619 0.697674
102 XAH 0.47619 0.775
103 9ZA 0.474747 0.746835
104 9ZD 0.474747 0.746835
105 APR 0.473118 0.773333
106 5FA 0.473118 0.75
107 AR6 0.473118 0.773333
108 AQP 0.473118 0.75
109 PRX 0.473118 0.753247
110 APC 0.473118 0.766234
111 WAQ 0.470588 0.815789
112 4AD 0.47 0.802632
113 NSS 0.47 0.697674
114 F2R 0.469565 0.756098
115 A5D 0.468085 0.84058
116 RBY 0.468085 0.789474
117 ADV 0.468085 0.789474
118 AD9 0.468085 0.730769
119 AGS 0.468085 0.7125
120 SAP 0.468085 0.7125
121 ADP PO3 0.468085 0.77027
122 MHZ 0.467391 0.782051
123 FA5 0.466667 0.813333
124 PTJ 0.466019 0.7375
125 00A 0.465347 0.746835
126 8X1 0.464646 0.693182
127 D3Y 0.464646 0.869565
128 VRT 0.463158 0.871429
129 GA7 0.462963 0.74359
130 LEU LMS 0.460784 0.674157
131 S8M 0.46 0.859155
132 OOB 0.46 0.786667
133 ADP VO4 0.459184 0.74026
134 VO4 ADP 0.459184 0.74026
135 T99 0.458333 0.721519
136 ANP 0.458333 0.730769
137 TAT 0.458333 0.721519
138 ACQ 0.458333 0.753247
139 B5V 0.456311 0.766234
140 AAT 0.453608 0.847222
141 2AM 0.453488 0.723684
142 8PZ 0.45283 0.697674
143 FYA 0.451923 0.786667
144 YLC 0.451327 0.797468
145 DLL 0.45098 0.786667
146 A3P 0.450549 0.746667
147 YLP 0.45045 0.777778
148 A22 0.45 0.74026
149 ARG AMP 0.449541 0.765432
150 ADP ALF 0.44898 0.7125
151 ALF ADP 0.44898 0.7125
152 2VA 0.446809 0.828571
153 OAD 0.446602 0.776316
154 3UK 0.446602 0.776316
155 80F 0.445378 0.73494
156 TYR AMP 0.444444 0.802632
157 6YZ 0.444444 0.753247
158 IOT 0.443478 0.768293
159 9SN 0.443396 0.7375
160 PR8 0.442308 0.807692
161 P5A 0.442308 0.704545
162 7D5 0.44186 0.714286
163 A1R 0.441176 0.769231
164 7C5 0.440367 0.797297
165 TT8 0.44 0.926471
166 YLA 0.439655 0.777778
167 YLB 0.438596 0.777778
168 3OD 0.438095 0.776316
169 9K8 0.438095 0.655556
170 BIS 0.438095 0.725
171 1ZZ 0.438095 0.753086
172 NVA 2AD 0.4375 0.859155
173 MAP 0.435644 0.7125
174 MYR AMP 0.433962 0.753086
175 NAI 0.433628 0.725
176 SO8 0.43299 0.816901
177 9X8 0.432692 0.734177
178 A6D 0.432692 0.74359
179 25A 0.431373 0.75
180 5SV 0.431373 0.7375
181 TYM 0.429825 0.813333
182 WSA 0.429825 0.705882
183 LAQ 0.428571 0.753086
184 3NZ 0.428571 0.833333
185 A3R 0.427184 0.769231
186 ADQ 0.427184 0.753247
187 8Q2 0.426087 0.674157
188 7MC 0.426087 0.756098
189 B5Y 0.425926 0.75641
190 B5M 0.425926 0.75641
191 LPA AMP 0.424779 0.753086
192 48N 0.424779 0.759494
193 JB6 0.424528 0.746835
194 PPS 0.424242 0.658824
195 AYB 0.423729 0.768293
196 PAP 0.42268 0.736842
197 OVE 0.422222 0.696203
198 3AD 0.421687 0.863636
199 4YB 0.419643 0.72093
200 A2P 0.419355 0.733333
201 CMP 0.419355 0.753425
202 2BA 0.419355 0.743243
203 ADP BMA 0.419048 0.753247
204 4UV 0.418182 0.75641
205 AHZ 0.415929 0.731707
206 QQX 0.41573 0.670886
207 A A 0.415094 0.75
208 AP0 0.413793 0.695122
209 ATP A A A 0.412844 0.76
210 SP1 0.411111 0.705128
211 QQY 0.411111 0.679487
212 ACK 0.411111 0.716216
213 RP1 0.411111 0.705128
214 AFH 0.410714 0.728395
215 4UU 0.410714 0.75641
216 DND 0.408696 0.766234
217 NXX 0.408696 0.766234
218 TXD 0.408696 0.725
219 7D3 0.408602 0.696203
220 CC5 0.407407 0.876923
221 25L 0.407407 0.74026
222 TAD 0.40708 0.75
223 DQV 0.40708 0.763158
224 AMP DBH 0.405405 0.753247
225 TXE 0.405172 0.725
226 AF3 ADP 3PG 0.405172 0.75
227 OMR 0.405172 0.743902
228 MTP 0.404762 0.72973
229 N0B 0.401575 0.777778
230 V3L 0.4 0.773333
231 YLY 0.4 0.768293
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3LKZ; Ligand: SFG; Similar sites found with APoc: 787
This union binding pocket(no: 1) in the query (biounit: 3lkz.bio2) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 1GXU 2HP None
2 2BOS GLA GAL GLC None
3 2YX1 SFG 0.934579
4 3GMB FAD 0.934579
5 2WYV NAD 1.14943
6 2BD0 NAP 1.22951
7 4O1M NAD 1.26984
8 6GNA FAD 1.38889
9 2VVL FAD 1.55763
10 2VVM FAD 1.55763
11 4Z24 FAD 1.55763
12 2GN4 NDP 1.55763
13 1V35 NAI 1.55763
14 2GN4 UD1 1.55763
15 1FDJ 13P 1.55763
16 3L8H FX1 1.67598
17 4Q9N NAI 1.67785
18 3BP1 GUN 1.72414
19 2PZE ATP 1.74672
20 1MFI FHC 1.75439
21 5O42 NAD 1.82482
22 5O42 BGC 1.82482
23 5O42 9JW 1.82482
24 4BV6 FAD 1.82556
25 1U2Z SAH 1.86916
26 5EB4 FAD 1.86916
27 1UWK URO 1.86916
28 1UWK NAD 1.86916
29 2XVE FAD 1.86916
30 3HB5 NAP 1.86916
31 2XVF FAD 1.86916
32 1QO8 FAD 1.86916
33 1OC2 NAD 1.86916
34 1OC2 TDX 1.86916
35 4NTC FAD 1.86916
36 5BUK FAD 1.86916
37 1H82 GZZ 1.86916
38 1PN0 FAD 1.86916
39 1PN0 IPH 1.86916
40 1H82 FAD 1.86916
41 5G3U FDA 1.86916
42 5G3U ITW 1.86916
43 3Q9T FAY 1.86916
44 4D5G TPP 1.86916
45 4D5G FAD 1.86916
46 2NVK FAD 1.86916
47 5L53 NAP 1.86916
48 4NRT 2NG 1.86916
49 1ZK7 FAD 1.92719
50 2OBF SAH 2.07612
51 2OBF F83 2.07612
52 1A27 NAP 2.07612
53 1TL2 NDG 2.11864
54 4M73 M72 2.18069
55 4M73 SAH 2.18069
56 1E1M NAP 2.18069
57 1E1M FAD 2.18069
58 3X0D SAH 2.18069
59 5JCM FAD 2.18069
60 5JCM NAD 2.18069
61 5JCM ISD 2.18069
62 5JAQ NAI 2.18069
63 1KEW NAD 2.18069
64 5X62 SAH 2.18069
65 4MOP 2H5 2.18069
66 4PIO SAH 2.18069
67 4PIO AVI 2.18069
68 6GAS FAD 2.18069
69 3ZNN FAD 2.18069
70 3ZNN 4WL 2.18069
71 5J5Z FAD 2.18069
72 2CDU FAD 2.18069
73 3X0V FAD 2.18069
74 3FPZ AHZ 2.18069
75 3E1T FAD 2.18069
76 2CDU ADP 2.18069
77 5WS9 AMP 2.18069
78 1RYI GOA 2.18069
79 1RYI FAD 2.18069
80 3T31 FAD 2.18069
81 3T31 DCQ 2.18069
82 1KEW TYD 2.18069
83 5DF1 58X 2.18069
84 5DF1 NAP 2.18069
85 6AIN FAD 2.18069
86 3ABI NAD 2.18069
87 1NNU TCT 2.18341
88 1NNU NAD 2.18341
89 3CTY FAD 2.19436
90 1GZ6 NAI 2.19436
91 3A27 SAM 2.20588
92 6F9Q NAD 2.20588
93 3DUW SAH 2.24215
94 5W7M SAH 2.24359
95 2YY7 NAD 2.24359
96 2Q0L FAD 2.2508
97 5EJ2 NAD 2.27273
98 4HXY NDP 2.28311
99 1E6E FAD 2.34375
100 4URF NAD 2.41935
101 5Z2L NDP 2.44898
102 1UAY ADN 2.47934
103 3TKA SAM 2.49221
104 2PT9 S4M 2.49221
105 2PT9 2MH 2.49221
106 3L9W AMP 2.49221
107 3HDY GDU 2.49221
108 3HDY FDA 2.49221
109 3HDY FAD 2.49221
110 3L9W GSH 2.49221
111 5BJX NAD 2.49221
112 5BJX UDP 2.49221
113 1RJD SAM 2.49221
114 2Q7V FAD 2.49221
115 2NPX NAD 2.49221
116 2NPX FAD 2.49221
117 4USR FAD 2.49221
118 2IZ1 ATR 2.49221
119 3NKS FAD 2.49221
120 5GSN FAD 2.49221
121 5GSN NAP 2.49221
122 5KOX RFP 2.49221
123 5KOX FAD 2.49221
124 3V1U NAD 2.49221
125 1GTE FAD 2.49221
126 6BWL NAD 2.49221
127 1WVG APR 2.49221
128 5GSN MMZ 2.49221
129 1RP0 AHZ 2.49221
130 4D04 NAP 2.49221
131 4D04 FAD 2.49221
132 5ZIC BMA Z4Y NAG 2.49221
133 2ZUX RAM 2.49221
134 1ORR NAD 2.49221
135 2B9W FAD 2.49221
136 1X87 NAD 2.49221
137 5L4S 6KX 2.51572
138 5L4S NAP 2.51572
139 2CBZ ATP 2.53165
140 2PD4 NAD 2.54545
141 4DDY DN6 2.6616
142 1B0U ATP 2.67176
143 3THR C2F 2.73038
144 4YAG NAI 2.76817
145 3VYW SAM 2.80374
146 4Y30 SAH 2.80374
147 4Y30 49L 2.80374
148 2C7G ODP 2.80374
149 2C7G FAD 2.80374
150 1KYZ SAH 2.80374
151 5HSA FAS 2.80374
152 3CGD COA 2.80374
153 3CGD FAD 2.80374
154 1R6D NAD 2.80374
155 1NAA 6FA 2.80374
156 1NAA ABL 2.80374
157 1KYZ FER 2.80374
158 1XHC FAD 2.80374
159 1QPB PYM 2.80374
160 3G5S FAD 2.80374
161 3CGD NAD 2.80374
162 5YF1 SFG 2.80374
163 5YF1 8V0 2.80374
164 1PS9 FAD 2.80374
165 2HQM FAD 2.80374
166 4EMI NAD 2.80374
167 4EMI FAD 2.80374
168 2QA1 FAD 2.80374
169 3KLJ FAD 2.80374
170 3FSY SCA 2.80374
171 1R6D DAU 2.80374
172 2WHX ADP 2.80374
173 3UOY FAD 2.80374
174 3UOY NAP 2.80374
175 3CQ5 PMP 2.80374
176 4DSG UDP 2.80374
177 4DSG FAD 2.80374
178 5K4G ASP 2.80374
179 5J60 FAD 2.8125
180 2I7C AAT 2.82686
181 3NUG NAD 2.83401
182 2JAH NDP 2.83401
183 2JAP NDP 2.83401
184 3A4V PYR 2.83912
185 3A4V NAD 2.83912
186 1QAN SAH 2.86885
187 4CQM NAP 2.86885
188 3GDH SAH 2.90456
189 3QWI NAP 2.96296
190 3QWI CUE 2.96296
191 5MGZ SAH 2.9661
192 1W8D NAP 2.98013
193 1W73 NAP 2.98013
194 1W6U NAP 2.98013
195 5GVR LMR 2.99145
196 1VL8 NAP 2.99625
197 2GDZ NAD 2.99625
198 5M58 SAH 3.04348
199 1QG6 NAD 3.06513
200 1QG6 TCL 3.06513
201 1E6W NAD 3.07692
202 1JQD SAH 3.08219
203 2AOT SAH 3.08219
204 1JQD HSM 3.08219
205 4N49 SAM 3.11526
206 3DMH GMP 3.11526
207 3DMH SAM 3.11526
208 4REP FAD 3.11526
209 2JHP SAH 3.11526
210 3S1S SAH 3.11526
211 1I8T FAD 3.11526
212 1Z45 NAD 3.11526
213 1UDB UFG 3.11526
214 1UDB NAD 3.11526
215 5VN0 FAD 3.11526
216 5VN0 NAI 3.11526
217 4DCM SAM 3.11526
218 1D4D FAD 3.11526
219 6GAR FAD 3.11526
220 1ELI PYC 3.11526
221 2BRY FAD 3.11526
222 2A8X FAD 3.11526
223 4M52 FAD 3.11526
224 5K4W THR 3.11526
225 6FP4 FAD 3.11526
226 5NA1 FAD 3.11526
227 5FTW SAH 3.125
228 3H4V DVP 3.125
229 3H4V NAP 3.125
230 1XX6 ADP 3.14136
231 2AQJ TRP 3.15985
232 2AQJ FAD 3.15985
233 3HVJ 705 3.16742
234 4K5S PM0 3.17164
235 4K5S FAD 3.17164
236 1XPJ TLA 3.1746
237 6BR8 PGV 3.1746
238 5E8J SAH 3.20513
239 5E9W SAH 3.20513
240 4XUC SAM 3.21101
241 4XUC 43G 3.21101
242 2VDV SAM 3.25203
243 3MAG SAH 3.25733
244 1WMA NDP 3.26087
245 1WMA AB3 3.26087
246 4Y9D NAI 3.27869
247 5CG1 NAD BBN 3.27869
248 4YUW 4JU 3.28947
249 4YUW S4M 3.28947
250 4JLS 3ZE 3.28947
251 1RRC ADP 3.32226
252 5OVL NAP 3.33333
253 1Z3C SA8 3.3557
254 3FPF TNA 3.3557
255 3FPF MTA 3.3557
256 3MCT SAH 3.367
257 3OIG NAD 3.38346
258 3EGI ADP 3.39806
259 6B92 SAH 3.40136
260 5BTX CMP 3.42466
261 5THY SAH 3.42679
262 2UYQ SAM 3.42679
263 5THZ SAH 3.42679
264 6ARJ BW4 3.42679
265 6ARJ SAH 3.42679
266 5DX8 SFG 3.42679
267 3M6W SAM 3.42679
268 5DXA SFG 3.42679
269 5DX1 SFG 3.42679
270 5DX0 SFG 3.42679
271 1YQZ FAD 3.42679
272 5DWQ SFG 3.42679
273 3GDN FAD 3.42679
274 3GDN HBX 3.42679
275 1V59 FAD 3.42679
276 2WET FAD 3.42679
277 2GMH FAD 3.42679
278 3CGB FAD 3.42679
279 3RNM FAD 3.42679
280 5TS5 FAD 3.42679
281 1V59 NAD 3.42679
282 2YVF FAD 3.42679
283 2YVF NAD 3.42679
284 3V0H I3P 3.42679
285 1U7T TDT 3.44828
286 1DL5 SAH 3.47003
287 5O98 NAP 3.47003
288 1LVG ADP 3.53535
289 3PPQ CHT 3.53698
290 3ZV6 NAD 3.55872
291 3ZV6 4HB 3.55872
292 1BDB NAD 3.61011
293 3I53 SAH 3.61446
294 2O07 MTA 3.61842
295 2O07 SPD 3.61842
296 5K0A FAD 3.63636
297 4FGC PQ0 3.63636
298 6EQS BV8 3.63636
299 3RIY NAD 3.663
300 1G55 SAH 3.73832
301 4ONQ SFG 3.73832
302 4MO2 FDA 3.73832
303 4MO2 FAD 3.73832
304 3GD4 NAD 3.73832
305 3GD4 FAD 3.73832
306 5FJN FAD 3.73832
307 5FJN BE2 3.73832
308 2C5A NAD 3.73832
309 2C5A GDC 3.73832
310 5MBX FAD 3.73832
311 5MBX SP5 3.73832
312 2BMB PMM 3.73832
313 4XFR CIT 3.73832
314 2IVD FAD 3.73832
315 5KMS FAD 3.73832
316 3LAD FAD 3.73832
317 1G0N PHH 3.73832
318 1G0N NDP 3.73832
319 1SB8 NAD 3.73832
320 1SB8 UD2 3.73832
321 3OZ2 FAD 3.73832
322 2RGO FAD 3.73832
323 6FHO FAD 3.73832
324 1R6B ADP 3.73832
325 5KMS NAD 3.73832
326 6EL3 NAP 3.73832
327 5X68 FAD 3.73832
328 1XDS SAM 3.74332
329 4NBT NAD 3.75
330 4BLW AMP 3.80623
331 4BLW SAH 3.80623
332 1N5D NDP 3.81944
333 3GU3 SAH 3.87324
334 3RJ5 NAD 3.93701
335 1YXM ADE 3.9604
336 6GFK SAH 3.98406
337 4POO SAM 4
338 4O0L NDP 4
339 1AE1 NAP 4.0293
340 4YAC NAI 4.0404
341 1N2X SAM 4.04984
342 5MPT SAH 4.04984
343 2JB2 FAD 4.04984
344 2JB2 PHE 4.04984
345 4MIG G3F 4.04984
346 1I2B NAD 4.04984
347 1I2B UPG 4.04984
348 1I2B USQ 4.04984
349 4AZW SAM 4.04984
350 3NTD FAD 4.04984
351 3COB ADP 4.04984
352 3NYC IAR 4.04984
353 3NYC FAD 4.04984
354 1FEC FAD 4.04984
355 1D7O TCL 4.04984
356 1D7O NAD 4.04984
357 3DC4 ADP 4.04984
358 1IM8 SAI 4.09836
359 3RFV 15L 4.11985
360 3RFV NAI 4.11985
361 3KIH GDL 4.12371
362 4F8L AES 4.13793
363 2NXE SAM 4.33071
364 4FN4 NAD 4.33071
365 4FC7 COA 4.33213
366 4FC7 NAP 4.33213
367 5TVI O8N 4.34783
368 5ZW3 SAH 4.36137
369 4M37 SAH 4.36137
370 1GY8 NAD 4.36137
371 3UCL CYH 4.36137
372 3UCL FAD 4.36137
373 3UCL NAP 4.36137
374 4FWE FAD 4.36137
375 1QZZ SAM 4.36137
376 3NT6 FAD 4.36137
377 1EK6 NAI 4.36137
378 1BXK NAD 4.36137
379 4AP3 NAP 4.36137
380 4AP3 FAD 4.36137
381 1COY AND 4.36137
382 5JWC FAD 4.36137
383 1GET FAD 4.36137
384 1GET NAP 4.36137
385 1EK6 UPG 4.36137
386 4D7E FAD 4.36137
387 1GOJ ADP 4.36137
388 5U8U FAD 4.36137
389 1COY FAD 4.36137
390 1RLZ NAD 4.36137
391 4HA6 FAD 4.36137
392 6A20 ADP 4.36137
393 5HXI FAD 4.36137
394 1W5T ADP 4.36137
395 4NBU NAI 4.4
396 1IY8 NAD 4.49438
397 2DTX BMA 4.54545
398 1WG8 SAM 4.5614
399 2DPM SAM 4.57746
400 3WV8 ATP 4.58716
401 4FZV SAM 4.60251
402 1XG5 NAP 4.6595
403 3PT9 SAH 4.6729
404 5WGR FAD 4.6729
405 5N0J FAD 4.6729
406 5TTJ FAD 4.6729
407 1VQW FAD 4.6729
408 2GV8 FAD 4.6729
409 2AWN ADP 4.6729
410 2GVC FAD 4.6729
411 2WPF FAD 4.6729
412 5TWB FAD 4.6729
413 2WPF WPF 4.6729
414 5ZYN FAD 4.6729
415 2DKH 3HB 4.6729
416 2DKH FAD 4.6729
417 3IHG FAD 4.6729
418 4YRY FAD 4.6729
419 4YRY NAD 4.6729
420 1OYJ GSH 4.6729
421 4RSL FAD 4.6729
422 2A14 SAH 4.6729
423 2XT3 ADP 4.6729
424 2V6G NAP 4.6729
425 5MLR NAP 4.6729
426 5MLR GRQ 4.6729
427 1ZBQ NAD 4.6729
428 1NW5 SAM 4.70219
429 3Q87 SAM 4.70588
430 2CUL FAD 4.74138
431 2Q46 NAP 4.74308
432 4CS9 AMP 4.7619
433 5BQ5 ADP BEF 4.7619
434 3FUU ADN 4.79705
435 1WY7 SAH 4.83092
436 4GUS FAD 4.83871
437 1I1N SAH 4.86726
438 5XLX SAH 4.96454
439 6DUB SAH 4.98442
440 5HJM MTA 4.98442
441 2EFJ SAH 4.98442
442 4A6D SAM 4.98442
443 1GPE FAD 4.98442
444 6F97 FAD 4.98442
445 3O26 NDP 4.98442
446 3FZG SAM 5
447 2PWY SAH 5.03876
448 4R6W PC 5.03876
449 4R6W SAH 5.03876
450 3AD8 NAD 5.05051
451 3AD8 FAD 5.05051
452 3AD8 PYC 5.05051
453 4YSX FAD 5.12821
454 5NII FAD 5.17799
455 4TXI FAD 5.20325
456 4J56 FAD 5.26316
457 1G60 SAM 5.29595
458 3P9C SAH 5.29595
459 1BZL FAD 5.29595
460 4CNK FAD 5.29595
461 1BZL GCG 5.29595
462 1LVL NAD 5.29595
463 1LVL FAD 5.29595
464 5K7U SAM 5.33333
465 1UYY BGC BGC 5.34351
466 5CK5 GDP 5.37975
467 1JJ7 ADP 5.38462
468 3A4M ADP 5.38462
469 1Q0S SAH 5.40541
470 4ZRN NAD 5.44872
471 4ZRN UPG 5.44872
472 2YVJ FAD 5.50459
473 4II2 ATP 5.52147
474 3SJ7 NDP 5.55556
475 1TPY SAH 5.57491
476 1KPH SAH 5.57491
477 1L1E SAH 5.57491
478 1KPG SAH 5.57491
479 2BZG SAH 5.60345
480 5ERG SAM 5.60748
481 6FDF SAH 5.60748
482 2EG5 SAH 5.60748
483 6D6Y SAH 5.60748
484 4RPL FAD 5.60748
485 4RPL 3UC 5.60748
486 1Y8Q ATP 5.60748
487 3QJ4 FAD 5.60748
488 6ER9 FAD 5.60748
489 6ER9 NAP 5.60748
490 3LZW FAD 5.60748
491 5I39 FAD 5.60748
492 3A28 NAD 5.60748
493 5FWA J7C 5.60748
494 3WGT QSC 5.60748
495 3WGT FAD 5.60748
496 3LU1 NAD 5.60748
497 5UAO FAD 5.60748
498 3X01 AMP 5.60748
499 5IL1 SAM 5.66038
500 4BQS ADP 5.68182
501 1XKQ NDP 5.71429
502 2ZIF SAM 5.72391
503 1ZEM NAD 5.72519
504 1VE3 SAM 5.72687
505 1DCP HBI 5.76923
506 3MB5 SAM 5.88235
507 4EUE NAI 5.919
508 3GWZ SAH 5.919
509 2ZWA SAH 5.919
510 4DMG SAM 5.919
511 3GXO SAH 5.919
512 6H3O FAD 5.919
513 3AXB FAD 5.919
514 3AXB PRO 5.919
515 2VVG ADP 5.919
516 2RGJ FAD 5.919
517 1G41 ADP 5.919
518 1JNR FAD 6
519 3G2O SAM 6.02007
520 1P1C SAH 6.03015
521 1UZN NAP 6.07287
522 1JQ3 AAT 6.08108
523 4IWN GEK 6.11354
524 3O7W SAM 6.12245
525 5LXB 7A9 6.19835
526 1MO9 KPC 6.23053
527 1MO9 FAD 6.23053
528 3ICT FAD 6.23053
529 3ICR FAD 6.23053
530 6DNT NAD 6.23053
531 3ICS FAD 6.23053
532 5OVK NDP 6.23053
533 2ZXI FAD 6.23053
534 5MIT FAD 6.23053
535 5MIT NAP 6.23053
536 4IEE AGS 6.23053
537 2RAB NAD 6.23053
538 4YKG FAD 6.23053
539 4YKG NAD 6.23053
540 2RAB FAD 6.23053
541 2HMT NAI 6.25
542 2F5Z FAD 6.25
543 3A25 SAM 6.31229
544 3C3Y SAH 6.32911
545 5Z2F PDC 6.41509
546 3DXY SAM 6.42202
547 3H8V ATP 6.50685
548 1C3V PDC 6.53061
549 5KOK SAH 6.54206
550 4X60 3XV 6.54206
551 4X60 SFG 6.54206
552 5KOK S9T 6.54206
553 5KOK R9T 6.54206
554 5EEH SAH 6.54206
555 5EEH P9P 6.54206
556 3RKR NAP 6.54206
557 5ICE SAH 6.54206
558 5ICE 2H4 6.54206
559 5XWV 8H6 6.54206
560 4IV9 FAD 6.54206
561 4ZCC NAI 6.54206
562 4ZCC FAD 6.54206
563 5XWV NDP 6.54206
564 2Q1S NAI 6.54206
565 4JNA FAD 6.54206
566 4C3Y FAD 6.54206
567 4AT0 FAD 6.54206
568 3LXD FAD 6.54206
569 4J36 1HR 6.54206
570 3SSO SAH 6.54206
571 4J36 FAD 6.54206
572 4C3Y ANB 6.54206
573 5Z75 NAD 6.54206
574 4EIP FAD 6.54206
575 5YV5 ADP 6.54206
576 1O97 FAD 6.5625
577 1O97 AMP 6.5625
578 1R18 SAH 6.60793
579 2WSB NAD 6.69291
580 5YEC ATP 6.72269
581 1XCL SAH 6.80851
582 5GWT NAD 6.83453
583 5GWT SIN 6.83453
584 2JJQ SAH 6.85358
585 3S5W FAD 6.85358
586 3NTA FAD 6.85358
587 4X9M FAD 6.85358
588 1V6A TRE 6.85358
589 3GEG NAD 6.88259
590 2AG5 NAD 6.91057
591 1KYQ NAD 6.93431
592 3OFK SAH 6.94444
593 2PXX SAH 6.97674
594 1G6H ADP 7.00389
595 3QPB URA 7.0922
596 5DM1 5D7 7.11611
597 5DM1 SAH 7.11611
598 1XSE NDP 7.11864
599 4TM3 FAD 7.16511
600 6GKV SAH 7.16511
601 1J78 OLA 7.16511
602 3CV2 OXL 7.16511
603 5EOW FAD 7.16511
604 3O03 NAP 7.2165
605 1ZQ9 SAM 7.36842
606 4OBW SAM 7.393
607 5YJI SAH 7.39437
608 5YJI 8WO 7.39437
609 2WK1 SAH 7.44681
610 1EFV FAD 7.45098
611 1EFV AMP 7.45098
612 2Z3Y F2N 7.47664
613 2FR1 NDP 7.47664
614 5MZI FYK 7.47664
615 5MZI FAD 7.47664
616 5Y77 FAD 7.47664
617 3AB1 FAD 7.47664
618 4EMJ FAD 7.47664
619 2BGM NAJ 7.47664
620 3WMX NAD 7.47664
621 1RKX NAD 7.47664
622 3SJU NDP 7.52688
623 5FEU NAP 7.56014
624 2B4Q NAP 7.6087
625 4OHU 2TK 7.61246
626 4OHU NAD 7.61246
627 1E3W NAD 7.66284
628 1PR9 NAP 7.78689
629 3D3W NAP 7.78689
630 4USQ FAD 7.78816
631 4RDH AMP 7.78816
632 4RDI ATP 7.78816
633 5E1M PRO PRO LYS ARG ILE ALA 7.88382
634 5E1M SAH 7.88382
635 2W58 ADP 7.92079
636 3BGD SAH 8.07692
637 3BGD PM6 8.07692
638 5WP5 SAH 8.09969
639 3TKY SAH 8.09969
640 1PJS NAD 8.09969
641 6CI9 NAP 8.10811
642 3AY6 NAI 8.17844
643 3AY6 BGC 8.17844
644 3U4C NDP 8.18505
645 1EJ0 SAM 8.33333
646 1MXH DHF 8.33333
647 1MXH NAP 8.33333
648 2HK9 ATR 8.36364
649 3A4T SFG 8.39416
650 5WP4 SAH 8.41121
651 2YG3 FAD 8.41121
652 2PK3 A2R 8.41121
653 1XHL NDP 8.41751
654 1NFQ NAI 8.46154
655 5NMX FAD 8.47059
656 5NMX NAP 8.47059
657 1VL0 NAI 8.56164
658 2WD7 NAP 8.58209
659 2VZ0 D64 8.58209
660 2VZ0 NAP 8.58209
661 4NBW NAD 8.72274
662 1SQL GUN 8.90411
663 3LCC SAH 8.93617
664 3OJF IMJ 8.94942
665 3OJF NDP 8.94942
666 6F7L FAD 9.03427
667 3FRH SAH 9.09091
668 4QTU SAM 9.13461
669 4D42 W0I 9.21986
670 4D42 NAP 9.21986
671 3WXB NDP 9.319
672 4B63 ORN 9.34579
673 4B63 NAP 9.34579
674 4B63 FAD 9.34579
675 3GF4 FAD 9.34579
676 3GF4 UPG 9.34579
677 2Y6Q FAD 9.34579
678 2Y6Q I7T 9.34579
679 3AYI FAD 9.34579
680 3AYI HCI 9.34579
681 1GEG NAD 9.375
682 2AE2 PTO 9.61539
683 2AE2 NAP 9.61539
684 3H4S ADP 9.62963
685 2EWM NAD 9.63855
686 3C6K MTA 9.65732
687 3C6K SPD 9.65732
688 1RSG FAD 9.65732
689 4U8P UDP 9.65732
690 4U8P FDA 9.65732
691 1TZD ADP 9.81818
692 3JWH SAH 10.1382
693 5DLY 5D7 10.1504
694 5DLY SAH 10.1504
695 2GAG NAD 10.4762
696 2GAG FAD 10.4762
697 2GAG FOA 10.4762
698 1H5Q NAP 10.566
699 4QED NAP 10.5919
700 4ITU NAI 10.7807
701 4ITU 1HS 10.7807
702 3G89 SAM 10.8434
703 1KNR FAD 10.9034
704 1JG3 ADN 11.0638
705 1RZ1 NAD 11.1801
706 3CBG SAH 11.2069
707 3QFA FAD 11.2069
708 4C4A SAH 11.215
709 4YNU FAD 11.215
710 4YNU LGC 11.215
711 5Y1G NAD 11.215
712 5Y1G AKB 11.215
713 3F8D FAD 11.215
714 3TLJ SAH 11.2601
715 5TSH ADP 11.5265
716 5TSH ANP 11.5265
717 3GD8 GOL 11.6592
718 3VSE SAH 11.809
719 5BRT FAD 11.838
720 5BRT CH9 11.838
721 4JDR FAD 11.838
722 4U00 ADP 11.8852
723 3LRE ADP 12.1127
724 2IID FAD 12.1495
725 2IID PHE 12.1495
726 5JCA FAD 12.4611
727 5JCA NDP 12.4611
728 5ODQ FAD 12.4611
729 5L95 AMP 12.5
730 5TCI MLI 12.6812
731 6BQ6 TER 12.6888
732 1EDO NAP 12.7049
733 1YY5 FAD 12.7726
734 3JQF NAP 12.8472
735 4CLO NAP 12.8472
736 4CM9 NAP 12.8472
737 3JQ9 NAP 12.8472
738 5JCJ NAP 12.8472
739 4CLR NAP 12.8472
740 4CMI NAP 12.8472
741 5K6A NAP 12.8472
742 4CME NAP 12.8472
743 3BMN NAP 12.8472
744 3BMQ NAP 12.8472
745 3JQ8 NAP 12.8472
746 4CM8 NAP 12.8472
747 5JDC NAP 12.8472
748 3JQB NAP 12.8472
749 4CM4 NAP 12.8472
750 3JQG NAP 12.8472
751 5JDI NAP 12.8472
752 3BMO NAP 12.8472
753 5WHT SIA GAL GLC 13.0435
754 5W7K SAH 13.0841
755 2R4J FAD 13.0841
756 2R4J 13P 13.0841
757 2XVM SAH 13.5678
758 2Q1W NAD 13.7072
759 2PZM NAD 13.7072
760 2PZM UDP 13.7072
761 4UCI SAM 14.0187
762 4L2I FAD 14.0684
763 5MW4 5JU 14.3302
764 3QOX SAH 14.3302
765 4BJZ FAD 14.3302
766 4BJZ P3A 14.3302
767 1NV8 MEQ 14.7887
768 1NV8 SAM 14.7887
769 3GRU AMP 15.9322
770 5FUB SAH 16.1994
771 2XYQ SAH 16.3934
772 1GEE NAD 16.4751
773 4J1Q NDP 16.8224
774 2FK8 SAM 16.9811
775 5GWX SAM 17.9577
776 5GWX SAR 17.9577
777 2EJU SAH 19.0031
778 1LSS NAD 20
779 5THQ NDP 20.2206
780 3VC1 SAH 20.8333
781 3VC1 GST 20.8333
782 2V7Q ADP 22.7273
783 4X7Y SAH 23.7226
784 4GQB 0XU 27.2727
785 1U4L H1S 27.9412
786 4M38 SAH 28.5714
787 5FA5 MTA 30
Pocket No.: 2; Query (leader) PDB : 3LKZ; Ligand: SFG; Similar sites found with APoc: 37
This union binding pocket(no: 2) in the query (biounit: 3lkz.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 3HQP OXL 1.24611
2 4LJ9 ACP 1.55763
3 4FCW ADP 1.60772
4 5W7R SAH 2.18069
5 4GLL NAD 2.49221
6 2PD4 DCN 2.54545
7 1O8B ABF 2.73973
8 4FRZ ADP 3.10881
9 5K4W NAI 3.11526
10 1JJV ATP 3.39806
11 5WUW NAP 3.48432
12 4AG5 ADP 3.73832
13 3KIF GDL 3.77358
14 2RH4 EMO 3.97112
15 3RUV ANP 4.04984
16 4KWI 1TJ 4.18251
17 4KWI NAP 4.18251
18 2P3V SRT 4.29688
19 2CFC NAD 4.4
20 4HSU FAD 4.83871
21 4GUT FAD 4.83871
22 4LHD GLY 4.98442
23 5OJI NAP 5
24 5OJI ISN 5
25 3LZW NAP 5.60748
26 2JK0 ASP 5.60748
27 4NAE 1GP 5.77778
28 1REO FAD 5.919
29 1H9A NAP 6.54206
30 1Q1R FAD 7.47664
31 1MZV AMP 7.65957
32 3KO8 NAD 7.69231
33 3OID NDP 7.75194
34 3TN7 NJP 8.17121
35 5LNE A2G GAL 8.53659
36 3JQA NAP 12.8472
37 1NXJ TLA 14.2077
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