Receptor
PDB id Resolution Class Description Source Keywords
3MFV 1.9 Å EC: 3.5.3.1 CRYSTAL STRUCTURE OF HUMAN ARGINASE I IN COMPLEX WITH 2- AMINOHOMOHISTIDINE HOMO SAPIENS MANGANESE COORDINATION STRUCTURE BASED DESIGN INHIBITION HYDROLASE HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Ref.: 2-AMINOIMIDAZOLE AMINO ACIDS AS INHIBITORS OF THE B MANGANESE METALLOENZYME HUMAN ARGINASE I. J.MED.CHEM. V. 53 4266 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MN A:614;
A:615;
B:614;
B:615;
 Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
none;
 submit data
54.938 Mn [Mn+2...
Z70 A:0;
B:323;
 Valid;
Valid;
 none;
none;
 Ki = 3000 uM
184.196 C7 H12 N4 O2 c1c([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6V7E 1.99 Å EC: 3.5.3.1 HUMAN ARGINASE1 COMPLEXED WITH BICYCLIC INHIBITOR COMPOUND 1 HOMO SAPIENS AGONIST ARG (ARGINASE) BICYCLIC IMMUNOTHERAPY METALLOENZHYDROLASE HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Ref.: DISCOVERY AND OPTIMIZATION OF RATIONALLY DESIGNED B INHIBITORS OF HUMAN ARGINASE TO ENHANCE CANCER IMMUNOTHERAPY. ACS MED.CHEM.LETT. V. 11 582 2020
Members (30)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 11 families.
1 3SKK - 4U7 C7 H15 B F2 N O5 [B-](CCCC[....
2 3GN0 Ki = 3.9 mM DMO C6 H12 F2 N2 O2 C(CC(C(F)F....
3 1WVA Kd = 270 nM S2C C5 H13 B N O5 S [B-](CCSC[....
4 3KV2 Kd = 47.51 nM NNH C5 H12 N4 O3 [H]/N=C(/N....
5 2PHO Kd > 0.1 mM TSZ C H5 N3 S C(=S)(N)NN
6 6V7D ic50 = 22 nM QR4 C11 H24 B N2 O5 [B-](CCC[C....
7 4IE1 - 1EC C9 H21 B N O6 [B-](CCCC[....
8 3MFW Ki = 300 uM B3U C6 H10 N4 O2 c1c([nH]c(....
9 3LP4 Kd = 13100 nM LYS C6 H15 N2 O2 C(CC[NH3+]....
10 3GMZ - ORN C5 H12 N2 O2 C(C[C@@H](....
11 4GSZ - ABH C6 H15 B N O5 [B-](CCCC[....
12 3SJT - 5AB C7 H17 B N O5 [B-](CCCC[....
13 2PLL Kd = 5 nM ABH C6 H15 B N O5 [B-](CCCC[....
14 3MFV Ki = 3000 uM Z70 C7 H12 N4 O2 c1c([nH]c(....
15 4GSV - ABH C6 H15 B N O5 [B-](CCCC[....
16 3DJ8 - EXY C8 H15 N O3 C1[C@H](O1....
17 1WVB - S2C C5 H13 B N O5 S [B-](CCSC[....
18 4HWW ic50 = 223 nM X7A C13 H28 B N2 O5 [B-](CCCC[....
19 3E6V Kd = 147 nM ABH C6 H15 B N O5 [B-](CCCC[....
20 3THH - ABH C6 H15 B N O5 [B-](CCCC[....
21 6V7E ic50 = 2 nM QRA C12 H24 B N2 O5 [B-](CCC[C....
22 3LP7 Kd = 3600 nM HAR C6 H14 N4 O3 C(C[C@@H](....
23 2AEB Kd = 5 nM ABH C6 H15 B N O5 [B-](CCCC[....
24 3THJ - ORN C5 H12 N2 O2 C(C[C@@H](....
25 6V7F ic50 = 14 nM QRJ C12 H26 B N2 O5 [B-](CCC[C....
26 3F80 Kd = 60 uM 6HN C6 H12 N2 O4 C(CC[N+](=....
27 3E6K Kd = 7000 nM ABH C6 H15 B N O5 [B-](CCCC[....
28 4HXQ ic50 = 60 nM X8A C14 H30 B N2 O5 [B-](CCCC[....
29 4GWD - ABH C6 H15 B N O5 [B-](CCCC[....
30 6V7C ic50 = 29 nM QR1 C11 H24 B N2 O5 [B-](CCC[C....
70% Homology Family (46)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 3SKK - 4U7 C7 H15 B F2 N O5 [B-](CCCC[....
2 3GN0 Ki = 3.9 mM DMO C6 H12 F2 N2 O2 C(CC(C(F)F....
3 1WVA Kd = 270 nM S2C C5 H13 B N O5 S [B-](CCSC[....
4 3KV2 Kd = 47.51 nM NNH C5 H12 N4 O3 [H]/N=C(/N....
5 2PHO Kd > 0.1 mM TSZ C H5 N3 S C(=S)(N)NN
6 6V7D ic50 = 22 nM QR4 C11 H24 B N2 O5 [B-](CCC[C....
7 4IE1 - 1EC C9 H21 B N O6 [B-](CCCC[....
8 3MFW Ki = 300 uM B3U C6 H10 N4 O2 c1c([nH]c(....
9 3LP4 Kd = 13100 nM LYS C6 H15 N2 O2 C(CC[NH3+]....
10 3GMZ - ORN C5 H12 N2 O2 C(C[C@@H](....
11 4GSZ - ABH C6 H15 B N O5 [B-](CCCC[....
12 3SJT - 5AB C7 H17 B N O5 [B-](CCCC[....
13 2PLL Kd = 5 nM ABH C6 H15 B N O5 [B-](CCCC[....
14 3MFV Ki = 3000 uM Z70 C7 H12 N4 O2 c1c([nH]c(....
15 4GSV - ABH C6 H15 B N O5 [B-](CCCC[....
16 3DJ8 - EXY C8 H15 N O3 C1[C@H](O1....
17 1WVB - S2C C5 H13 B N O5 S [B-](CCSC[....
18 4HWW ic50 = 223 nM X7A C13 H28 B N2 O5 [B-](CCCC[....
19 3E6V Kd = 147 nM ABH C6 H15 B N O5 [B-](CCCC[....
20 3THH - ABH C6 H15 B N O5 [B-](CCCC[....
21 6V7E ic50 = 2 nM QRA C12 H24 B N2 O5 [B-](CCC[C....
22 3LP7 Kd = 3600 nM HAR C6 H14 N4 O3 C(C[C@@H](....
23 2AEB Kd = 5 nM ABH C6 H15 B N O5 [B-](CCCC[....
24 3THJ - ORN C5 H12 N2 O2 C(C[C@@H](....
25 6V7F ic50 = 14 nM QRJ C12 H26 B N2 O5 [B-](CCC[C....
26 3F80 Kd = 60 uM 6HN C6 H12 N2 O4 C(CC[N+](=....
27 3E6K Kd = 7000 nM ABH C6 H15 B N O5 [B-](CCCC[....
28 4HXQ ic50 = 60 nM X8A C14 H30 B N2 O5 [B-](CCCC[....
29 4GWD - ABH C6 H15 B N O5 [B-](CCCC[....
30 6V7C ic50 = 29 nM QR1 C11 H24 B N2 O5 [B-](CCC[C....
31 4I06 ic50 = 67 nM X8A C14 H30 B N2 O5 [B-](CCCC[....
32 4IXV ic50 = 240 nM XA1 C18 H29 B Cl N2 O5 [B-](CCCC[....
33 4IE3 ic50 = 980 nM 1EE C13 H28 B N2 O6 [B-](CCCC[....
34 4IE2 ic50 = 4500 nM 1EC C9 H21 B N O6 [B-](CCCC[....
35 4HZE ic50 = 509 nM X7A C13 H28 B N2 O5 [B-](CCCC[....
36 6Q37 ic50 = 440 nM HE8 C8 H18 B N2 O5 [B-](CCC[C....
37 6Q39 ic50 = 16 nM HDQ C14 H29 B N3 O5 [B-](CCC[C....
38 4IXU ic50 = 23 nM 38I C20 H30 B Cl2 N2 O5 [B-](CCCC[....
39 1T5G - ARG C6 H15 N4 O2 C(C[C@@H](....
40 1D3V Kd = 0.11 uM ABH C6 H15 B N O5 [B-](CCCC[....
41 1HQG - ORN C5 H12 N2 O2 C(C[C@@H](....
42 1T4T ic50 < 400 uM DIR C4 H10 N4 O3 C([C@@H](C....
43 1T5F Ki = 60 uM DHH C7 H15 N O4 C(CCC(O)O)....
44 1P8R - S2C C5 H13 B N O5 S [B-](CCSC[....
45 1HQ5 Kd = 2.22 uM S2C C5 H13 B N O5 S [B-](CCSC[....
46 3E9B Ki = 4500 nM S2C C5 H13 B N O5 S [B-](CCSC[....
50% Homology Family (61)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 4Q3S Kd = 0.26 uM X7A C13 H28 B N2 O5 [B-](CCCC[....
2 4Q42 - ORN C5 H12 N2 O2 C(C[C@@H](....
3 4Q40 - VAL C5 H11 N O2 CC(C)[C@@H....
4 4Q3U Kd = 0.36 uM NNH C5 H12 N4 O3 [H]/N=C(/N....
5 4Q41 - LYS C6 H15 N2 O2 C(CC[NH3+]....
6 4Q3Q Kd = 1.3 uM ABH C6 H15 B N O5 [B-](CCCC[....
7 4Q3T Kd = 0.33 uM HAR C6 H14 N4 O3 C(C[C@@H](....
8 3SKK - 4U7 C7 H15 B F2 N O5 [B-](CCCC[....
9 3GN0 Ki = 3.9 mM DMO C6 H12 F2 N2 O2 C(CC(C(F)F....
10 1WVA Kd = 270 nM S2C C5 H13 B N O5 S [B-](CCSC[....
11 3KV2 Kd = 47.51 nM NNH C5 H12 N4 O3 [H]/N=C(/N....
12 2PHO Kd > 0.1 mM TSZ C H5 N3 S C(=S)(N)NN
13 6V7D ic50 = 22 nM QR4 C11 H24 B N2 O5 [B-](CCC[C....
14 4IE1 - 1EC C9 H21 B N O6 [B-](CCCC[....
15 3MFW Ki = 300 uM B3U C6 H10 N4 O2 c1c([nH]c(....
16 3LP4 Kd = 13100 nM LYS C6 H15 N2 O2 C(CC[NH3+]....
17 3GMZ - ORN C5 H12 N2 O2 C(C[C@@H](....
18 4GSZ - ABH C6 H15 B N O5 [B-](CCCC[....
19 3SJT - 5AB C7 H17 B N O5 [B-](CCCC[....
20 2PLL Kd = 5 nM ABH C6 H15 B N O5 [B-](CCCC[....
21 3MFV Ki = 3000 uM Z70 C7 H12 N4 O2 c1c([nH]c(....
22 4GSV - ABH C6 H15 B N O5 [B-](CCCC[....
23 3DJ8 - EXY C8 H15 N O3 C1[C@H](O1....
24 1WVB - S2C C5 H13 B N O5 S [B-](CCSC[....
25 4HWW ic50 = 223 nM X7A C13 H28 B N2 O5 [B-](CCCC[....
26 3E6V Kd = 147 nM ABH C6 H15 B N O5 [B-](CCCC[....
27 3THH - ABH C6 H15 B N O5 [B-](CCCC[....
28 6V7E ic50 = 2 nM QRA C12 H24 B N2 O5 [B-](CCC[C....
29 3LP7 Kd = 3600 nM HAR C6 H14 N4 O3 C(C[C@@H](....
30 2AEB Kd = 5 nM ABH C6 H15 B N O5 [B-](CCCC[....
31 3THJ - ORN C5 H12 N2 O2 C(C[C@@H](....
32 6V7F ic50 = 14 nM QRJ C12 H26 B N2 O5 [B-](CCC[C....
33 3F80 Kd = 60 uM 6HN C6 H12 N2 O4 C(CC[N+](=....
34 3E6K Kd = 7000 nM ABH C6 H15 B N O5 [B-](CCCC[....
35 4HXQ ic50 = 60 nM X8A C14 H30 B N2 O5 [B-](CCCC[....
36 4GWD - ABH C6 H15 B N O5 [B-](CCCC[....
37 6V7C ic50 = 29 nM QR1 C11 H24 B N2 O5 [B-](CCC[C....
38 4I06 ic50 = 67 nM X8A C14 H30 B N2 O5 [B-](CCCC[....
39 4IXV ic50 = 240 nM XA1 C18 H29 B Cl N2 O5 [B-](CCCC[....
40 4IE3 ic50 = 980 nM 1EE C13 H28 B N2 O6 [B-](CCCC[....
41 4IE2 ic50 = 4500 nM 1EC C9 H21 B N O6 [B-](CCCC[....
42 4HZE ic50 = 509 nM X7A C13 H28 B N2 O5 [B-](CCCC[....
43 6Q37 ic50 = 440 nM HE8 C8 H18 B N2 O5 [B-](CCC[C....
44 6Q39 ic50 = 16 nM HDQ C14 H29 B N3 O5 [B-](CCC[C....
45 4IXU ic50 = 23 nM 38I C20 H30 B Cl2 N2 O5 [B-](CCCC[....
46 4IU4 Ki ~ 10 uM S2C C5 H13 B N O5 S [B-](CCSC[....
47 4IU1 Ki ~ 50 uM NNH C5 H12 N4 O3 [H]/N=C(/N....
48 4IU5 - ORN C5 H12 N2 O2 C(C[C@@H](....
49 4IU0 Ki = 1.3 uM ABH C6 H15 B N O5 [B-](CCCC[....
50 1T5G - ARG C6 H15 N4 O2 C(C[C@@H](....
51 1D3V Kd = 0.11 uM ABH C6 H15 B N O5 [B-](CCCC[....
52 1HQG - ORN C5 H12 N2 O2 C(C[C@@H](....
53 1T4T ic50 < 400 uM DIR C4 H10 N4 O3 C([C@@H](C....
54 1T5F Ki = 60 uM DHH C7 H15 N O4 C(CCC(O)O)....
55 1P8R - S2C C5 H13 B N O5 S [B-](CCSC[....
56 1HQ5 Kd = 2.22 uM S2C C5 H13 B N O5 S [B-](CCSC[....
57 3E9B Ki = 4500 nM S2C C5 H13 B N O5 S [B-](CCSC[....
58 5ZEE - HAR C6 H14 N4 O3 C(C[C@@H](....
59 5ZEF - NVA C5 H11 N O2 CCC[C@@H](....
60 5CEV - LYS C6 H15 N2 O2 C(CC[NH3+]....
61 3CEV - ARG C6 H15 N4 O2 C(C[C@@H](....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: Z70; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 Z70 1 1
2 B3U 0.6 0.926829
Similar Ligands (3D)
Ligand no: 1; Ligand: Z70; Similar ligands found: 412
No: Ligand Similarity coefficient
1 API 0.9541
2 ENO 0.9427
3 NNH 0.9403
4 XI7 0.9398
5 A51 0.9339
6 ARG 0.9329
7 11X 0.9302
8 26P 0.9301
9 HFA 0.9297
10 HAR 0.9280
11 6HN 0.9262
12 HIS 0.9242
13 FZM 0.9241
14 OJD 0.9234
15 P58 0.9232
16 PPY 0.9224
17 E4P 0.9211
18 F90 0.9198
19 M3L 0.9193
20 M6H 0.9192
21 AHN 0.9192
22 N9J 0.9185
23 1PS 0.9181
24 92G 0.9181
25 1BN 0.9175
26 SOJ 0.9175
27 N2Y 0.9170
28 GVA 0.9157
29 GGB 0.9150
30 JX7 0.9147
31 TYR 0.9147
32 DHH 0.9144
33 NPI 0.9144
34 SB7 0.9137
35 0A9 0.9131
36 M74 0.9131
37 LVD 0.9129
38 PHE 0.9129
39 LL2 0.9124
40 EQW 0.9123
41 PML 0.9113
42 YIE 0.9108
43 ILO 0.9106
44 6C8 0.9106
45 RP3 0.9105
46 LZ5 0.9103
47 4FP 0.9101
48 6MW 0.9095
49 DHC 0.9093
50 HIC 0.9092
51 C82 0.9089
52 MLY 0.9087
53 TIH 0.9085
54 37E 0.9082
55 KPV 0.9081
56 DTY 0.9081
57 5TO 0.9080
58 TRP 0.9079
59 JMG 0.9078
60 ERZ 0.9076
61 CIR 0.9075
62 50C 0.9075
63 4JK 0.9069
64 P80 0.9067
65 S0F 0.9066
66 2LT 0.9065
67 HCI 0.9065
68 9YT 0.9065
69 3YP 0.9062
70 6C5 0.9058
71 BSA 0.9052
72 2NP 0.9047
73 6C9 0.9043
74 YIP 0.9039
75 F18 0.9036
76 DAR 0.9035
77 IAR 0.9035
78 4TB 0.9033
79 4YZ 0.9033
80 TB8 0.9028
81 TEG 0.9023
82 0K7 0.9021
83 WT2 0.9019
84 TMG 0.9017
85 ABH 0.9014
86 3VW 0.9010
87 DA3 0.9007
88 6J5 0.9006
89 GNW 0.9001
90 6FG 0.9000
91 HX4 0.8999
92 DAH 0.8999
93 DHI 0.8998
94 BNL 0.8995
95 JGY 0.8993
96 XCG 0.8991
97 HC4 0.8986
98 ENW 0.8986
99 A7Q 0.8986
100 TOH 0.8979
101 0NX 0.8979
102 54F 0.8979
103 3QO 0.8978
104 NFA 0.8977
105 RLG 0.8975
106 5PV 0.8973
107 GB5 0.8971
108 KYN 0.8968
109 9VQ 0.8965
110 ALY 0.8962
111 Q06 0.8962
112 Q9Z 0.8956
113 HL4 0.8955
114 OOG 0.8952
115 AOY 0.8950
116 F4E 0.8947
117 HNK 0.8947
118 HNL 0.8947
119 ENG 0.8944
120 GLR 0.8939
121 ZZU 0.8939
122 PFF 0.8939
123 6L6 0.8938
124 3H2 0.8937
125 K80 0.8936
126 DA2 0.8933
127 MLZ 0.8933
128 TCA 0.8928
129 E3X 0.8928
130 XRX 0.8928
131 848 0.8926
132 J0Z 0.8926
133 ZEC 0.8925
134 MF3 0.8924
135 1X4 0.8921
136 PRO GLY 0.8918
137 0OY 0.8910
138 TYC 0.8905
139 BZE 0.8904
140 MJW 0.8904
141 7OD 0.8902
142 J4K 0.8902
143 LPA 0.8901
144 DHM 0.8900
145 LPB 0.8898
146 P81 0.8898
147 UN1 0.8898
148 QME 0.8898
149 RGP 0.8897
150 S0D 0.8895
151 XDK 0.8893
152 28A 0.8893
153 EXY 0.8892
154 XIZ 0.8892
155 HO6 0.8891
156 X48 0.8890
157 NMM 0.8888
158 PBN 0.8888
159 HPP 0.8887
160 Q04 0.8885
161 EQA 0.8884
162 68B 0.8882
163 KPA 0.8882
164 CBE 0.8880
165 A8K 0.8876
166 ENV 0.8875
167 G14 0.8875
168 TR7 0.8872
169 6H2 0.8869
170 SB9 0.8869
171 NOT 0.8868
172 HNH 0.8868
173 7R4 0.8867
174 YOF 0.8866
175 DPN 0.8866
176 GZ2 0.8865
177 S7S 0.8862
178 J9N 0.8862
179 CS2 0.8860
180 4LV 0.8859
181 MES 0.8856
182 VUR 0.8856
183 4Z1 0.8855
184 3IL 0.8854
185 RES 0.8852
186 CPZ 0.8850
187 3KJ 0.8850
188 1N5 0.8849
189 PUE 0.8848
190 HJH 0.8848
191 MPV 0.8847
192 JFM 0.8847
193 6SD 0.8844
194 DXG 0.8843
195 11C 0.8843
196 AHL 0.8842
197 ZZA 0.8840
198 7O4 0.8840
199 2UB 0.8837
200 4TP 0.8835
201 HXY 0.8834
202 DYT 0.8833
203 4BF 0.8833
204 4LW 0.8832
205 O45 0.8830
206 C0H 0.8830
207 4XF 0.8829
208 5S9 0.8822
209 PO6 0.8821
210 F4K 0.8818
211 E79 0.8817
212 JCZ 0.8815
213 1L5 0.8815
214 RKV 0.8815
215 SX2 0.8813
216 TYE 0.8813
217 CXP 0.8812
218 HRG 0.8812
219 FK8 0.8811
220 MMS 0.8811
221 C53 0.8811
222 833 0.8810
223 2JJ 0.8810
224 2FM 0.8809
225 HX8 0.8808
226 MSR 0.8807
227 DIR 0.8807
228 5OY 0.8805
229 IPO 0.8804
230 KDG 0.8804
231 LYS 0.8802
232 EAT 0.8802
233 2JX 0.8801
234 SWX 0.8799
235 1KN 0.8798
236 BVS 0.8798
237 J9Y 0.8798
238 URO 0.8798
239 PH3 0.8796
240 5KJ 0.8796
241 U13 0.8795
242 2B4 0.8794
243 THU 0.8793
244 7VY 0.8793
245 6C4 0.8791
246 EN1 0.8791
247 CK2 0.8790
248 BQ2 0.8790
249 4FF 0.8785
250 HSX 0.8784
251 D3G 0.8783
252 AOT 0.8781
253 363 0.8781
254 PBA 0.8780
255 EVF 0.8780
256 IVL 0.8779
257 2D2 0.8779
258 FMQ 0.8779
259 3GZ 0.8778
260 S0A 0.8777
261 3IP 0.8776
262 TCC 0.8776
263 1YO 0.8775
264 A5E 0.8775
265 PPT 0.8775
266 SNU 0.8774
267 3TC 0.8773
268 1A5 0.8772
269 WCU 0.8771
270 0UL 0.8770
271 1XS 0.8769
272 3VQ 0.8769
273 54E 0.8767
274 9VZ 0.8765
275 EYJ 0.8765
276 OCA 0.8762
277 IYR 0.8762
278 ZRK 0.8754
279 TOM 0.8754
280 BPY 0.8753
281 64Z 0.8752
282 DXP 0.8751
283 X6W 0.8749
284 XRS 0.8746
285 QUS 0.8744
286 2QC 0.8743
287 FF2 0.8743
288 6Q3 0.8741
289 MVH 0.8738
290 7BC 0.8738
291 XOG 0.8734
292 MP5 0.8734
293 ODK 0.8732
294 SOL 0.8732
295 JPQ 0.8730
296 9BF 0.8729
297 1Z6 0.8728
298 0XR 0.8727
299 9GB 0.8726
300 0SY 0.8725
301 JAH 0.8722
302 HF2 0.8722
303 OJM 0.8722
304 5LD 0.8720
305 ZIQ 0.8719
306 AHC 0.8719
307 S0W 0.8718
308 GRQ 0.8717
309 LTT 0.8716
310 D2G 0.8715
311 TPM 0.8714
312 TIA 0.8714
313 GT4 0.8713
314 RA7 0.8709
315 AVX 0.8709
316 5AB 0.8708
317 0ON 0.8708
318 GB4 0.8708
319 9PL 0.8706
320 GAE 0.8706
321 6ZX 0.8705
322 7MW 0.8705
323 YIH 0.8704
324 FB6 0.8703
325 S7D 0.8703
326 BRH 0.8703
327 SHI 0.8700
328 I3E 0.8700
329 3D8 0.8694
330 DLT 0.8693
331 FHV 0.8692
332 D1Y 0.8692
333 36M 0.8689
334 XYP XIF 0.8687
335 7VP 0.8686
336 650 0.8682
337 492 0.8679
338 9J6 0.8677
339 PJW 0.8675
340 FCW 0.8673
341 DDK 0.8671
342 1A7 0.8669
343 B41 0.8666
344 SLZ 0.8666
345 DBS 0.8665
346 5DS 0.8663
347 LUQ 0.8661
348 7ZL 0.8661
349 HGA 0.8661
350 C1M 0.8660
351 5AD 0.8659
352 PHI 0.8659
353 N9M 0.8658
354 LSQ 0.8658
355 EGV 0.8658
356 B40 0.8656
357 3VR 0.8653
358 LGT 0.8649
359 R9J 0.8648
360 5O5 0.8647
361 ONH 0.8646
362 5DL 0.8644
363 2GA 0.8642
364 XYH 0.8639
365 I58 0.8638
366 GCO 0.8638
367 F06 0.8637
368 4G2 0.8636
369 1OS 0.8632
370 5O6 0.8632
371 S8V 0.8629
372 SV4 0.8626
373 MJ5 0.8626
374 7C3 0.8625
375 DEZ 0.8624
376 S2P 0.8623
377 L06 0.8618
378 78U 0.8614
379 3SU 0.8612
380 CK1 0.8612
381 FPL 0.8609
382 4Z9 0.8608
383 DCN 0.8602
384 XIF XYP 0.8601
385 IOP 0.8598
386 LR8 0.8597
387 A6H 0.8595
388 R2P 0.8595
389 MXD 0.8592
390 A4N 0.8590
391 R5P 0.8586
392 L13 0.8585
393 F02 0.8584
394 977 0.8584
395 36Y 0.8576
396 5OO 0.8571
397 E8U 0.8566
398 XDL XYP 0.8563
399 HQJ 0.8563
400 42R 0.8562
401 16Z 0.8558
402 SG3 0.8557
403 47V 0.8551
404 CFA 0.8551
405 TAG 0.8550
406 JM2 0.8550
407 94X 0.8537
408 E9S 0.8533
409 KMY 0.8530
410 HMS 0.8529
411 2OR 0.8525
412 F98 0.8510
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6V7E; Ligand: QRA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6v7e.bio2) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 6V7E; Ligand: QRA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 6v7e.bio2) has 17 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 6V7E; Ligand: QRA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 6v7e.bio2) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 6V7E; Ligand: QRA; Similar sites found with APoc: 3
This union binding pocket(no: 4) in the query (biounit: 6v7e.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 1WOG 16D 39.3443
2 1WOG 16D 39.3443
3 1WOG 16D 39.3443
Pocket No.: 5; Query (leader) PDB : 6V7E; Ligand: QRA; Similar sites found with APoc: 3
This union binding pocket(no: 5) in the query (biounit: 6v7e.bio1) has 23 residues
No: Leader PDB Ligand Sequence Similarity
1 1WOG 16D 39.3443
2 1WOG 16D 39.3443
3 1WOG 16D 39.3443
Pocket No.: 6; Query (leader) PDB : 6V7E; Ligand: QRA; Similar sites found with APoc: 2
This union binding pocket(no: 6) in the query (biounit: 6v7e.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 1WOG 16D 39.3443
2 1WOG 16D 39.3443
APoc FAQ
Feedback