Receptor
PDB id Resolution Class Description Source Keywords
3ONW 2.38 Å EC: 3.6.5.1 STRUCTURE OF A G-ALPHA-I1 MUTANT WITH ENHANCED AFFINITY FOR GOLOCO MOTIF. HOMO SAPIENS RGS14 GOLOCO ROSETTA PROTEIN DESIGN AFFINITY ENHANCEMENTDOMAIN ALL-HELICAL DOMAIN GOLOCO MOTIF ARGININE FINGER PROTEIN LIPOPROTEIN TRANSDUCER GUANINE NUCLEOTIDE DISSOCINHIBITOR GTP BINDING NUCLEOTIDE BINDING ADP-RIBOSYLATIO
Ref.: STRUCTURAL DETERMINANTS OF AFFINITY ENHANCEMENT BET GOLOCO MOTIFS AND G-PROTEIN {ALPHA} SUBUNIT MUTANTS J.BIOL.CHEM. V. 286 3351 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GDP A:401;
B:401;
Valid;
Valid;
none;
none;
submit data
443.201 C10 H15 N5 O11 P2 c1nc2...
SO4 A:3;
B:1;
B:2;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2OM2 2.2 Å EC: 3.6.5.1 CRYSTAL STRUCTURE OF HUMAN G[ALPHA]I1 BOUND TO THE GOLOCO MOTIF OF RGS14 HOMO SAPIENS ARGININE FINGER RGS14 GOLOCO SIGNALING PROTEIN
Ref.: STRUCTURE-BASED PROTOCOL FOR IDENTIFYING MUTATIONS THAT ENHANCE PROTEIN-PROTEIN BINDING AFFINITIES. J.MOL.BIOL. V. 371 1392 2007
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2OM2 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 3ONW - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2OM2 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 3ONW - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2OM2 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 3ONW - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GDP; Similar ligands found: 153
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 1 1
2 GTP 0.909091 1
3 GP3 0.881579 0.973684
4 GNH 0.858974 0.986667
5 GNP 0.839506 0.973684
6 G 0.828947 0.986486
7 5GP 0.828947 0.986486
8 G1R 0.82716 0.986667
9 GCP 0.82716 0.973684
10 GSP 0.817073 0.948718
11 GAV 0.797619 0.961039
12 GMV 0.792683 0.973684
13 G2P 0.77381 0.961039
14 G2R 0.770115 0.961039
15 GDP MG 0.759036 0.923077
16 GP2 0.756098 0.961039
17 GDP BEF 0.75 0.9
18 GDD 0.747253 0.961039
19 GKE 0.747253 0.961039
20 GDC 0.747253 0.961039
21 GPG 0.741573 0.961039
22 G3D 0.732558 0.986486
23 ALF 5GP 0.729412 0.888889
24 Y9Z 0.728261 0.902439
25 GTP MG 0.724138 0.923077
26 BEF GDP 0.724138 0.888889
27 G5P 0.723404 0.973684
28 GFB 0.72043 0.961039
29 GTG 0.72043 0.936709
30 GDR 0.72043 0.961039
31 G4P 0.715909 0.986486
32 GCP G 0.715909 0.935065
33 6CK 0.712766 0.936709
34 G3A 0.712766 0.973684
35 GDP ALF 0.7 0.888889
36 GDP AF3 0.7 0.888889
37 YGP 0.698925 0.901235
38 JB2 0.697917 0.961039
39 GKD 0.697917 0.961039
40 GDX 0.690722 0.973684
41 GPD 0.690722 0.925
42 GMP 0.684211 0.88
43 0O2 0.666667 0.986486
44 G G 0.659574 0.935065
45 JB3 0.656863 0.948718
46 NGD 0.650485 0.961039
47 GDP 7MG 0.636364 0.911392
48 DGI 0.636364 0.923077
49 U2G 0.634615 0.936709
50 GPX 0.634409 0.946667
51 IDP 0.632184 0.972973
52 2MD 0.632075 0.891566
53 CAG 0.62963 0.880952
54 CG2 0.622642 0.936709
55 FEG 0.619048 0.879518
56 MGD 0.614679 0.891566
57 ZGP 0.613208 0.869048
58 GH3 0.612903 0.973333
59 3GP 0.611765 0.946667
60 MD1 0.607143 0.891566
61 PGD 0.59292 0.925
62 DGT 0.591398 0.923077
63 BGO 0.588785 0.924051
64 TPG 0.582609 0.840909
65 DBG 0.582609 0.948718
66 2GP 0.574713 0.96
67 FE9 0.570175 0.776596
68 I2C FE2 CMO CMO 0.566372 0.808989
69 G A A A 0.553571 0.923077
70 MGP 0.553191 0.961039
71 U A G G 0.548673 0.935065
72 G4M 0.548387 0.880952
73 6G0 0.547368 0.961039
74 G1R G1R 0.542373 0.924051
75 P2G 0.527473 0.883117
76 PGD O 0.525 0.850575
77 ADP 0.522222 0.92
78 GGM 0.517544 0.901235
79 DG 0.516484 0.910256
80 DGP 0.516484 0.910256
81 P1G 0.516129 0.871795
82 G G U 0.509259 0.935065
83 G1G 0.508475 0.925
84 IMP 0.505495 0.959459
85 G C 0.504348 0.9
86 GPC 0.491525 0.879518
87 G7M 0.483871 0.948052
88 6AD 0.479592 0.841463
89 ATP 0.473684 0.92
90 G2Q 0.471154 0.961039
91 U G A 0.469697 0.888889
92 5FA 0.46875 0.92
93 AQP 0.46875 0.92
94 GTA 0.468468 0.936709
95 7DD 0.468085 0.906667
96 G G G RPC 0.466102 0.875
97 SGP 0.463158 0.82716
98 01G 0.462963 0.902439
99 B4P 0.457447 0.894737
100 AP5 0.457447 0.894737
101 A2D 0.456522 0.894737
102 G G G C 0.455285 0.9125
103 ACQ 0.454545 0.896104
104 5GP 5GP 0.454545 0.883117
105 ANP 0.454545 0.896104
106 A G C C 0.451613 0.911392
107 APC G U 0.45082 0.886076
108 G U34 0.449153 0.888889
109 DG DG 0.448598 0.865854
110 ITT 0.447917 0.868421
111 BA3 0.446809 0.894737
112 35G 0.444444 0.933333
113 C2E 0.444444 0.921053
114 PCG 0.444444 0.933333
115 MGO 0.441176 0.864198
116 AN2 0.4375 0.907895
117 G C C C 0.4375 0.924051
118 M33 0.43299 0.883117
119 UCG 0.429688 0.911392
120 A G U 0.42963 0.888889
121 ACP 0.428571 0.896104
122 MGQ 0.424528 0.935897
123 7DT 0.424242 0.906667
124 APR 0.424242 0.894737
125 AR6 0.424242 0.894737
126 93A 0.42268 0.833333
127 A4P 0.420168 0.869048
128 SAP 0.42 0.873418
129 AD9 0.42 0.896104
130 AGS 0.42 0.873418
131 G8D 0.42 0.875
132 CA0 0.418367 0.896104
133 ATF 0.417476 0.884615
134 AGO 0.414634 0.888889
135 NIA 0.413043 0.82716
136 MGV 0.412844 0.890244
137 TAT 0.411765 0.884615
138 A1R 0.411215 0.839506
139 ADQ 0.411215 0.871795
140 RGT 0.410714 0.909091
141 CGP 0.409836 0.86747
142 AMP 0.408602 0.893333
143 A 0.408602 0.893333
144 UP5 0.40678 0.873418
145 C2R 0.406593 0.906667
146 AMZ 0.406593 0.918919
147 JBT 0.405882 0.778947
148 A22 0.40566 0.907895
149 25L 0.405405 0.907895
150 ADX 0.40404 0.809524
151 8OD 0.401961 0.946667
152 4TC 0.4 0.851852
153 50T 0.4 0.883117
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2OM2; Ligand: GDP; Similar sites found: 548
This union binding pocket(no: 1) in the query (biounit: 2om2.bio2) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1YZQ GNP 0.000001047 0.57326 None
2 2Y8E GNP 0.0000009581 0.57257 None
3 1GXU 2HP 0.001597 0.45643 None
4 5KSP GDP 0.000002087 0.51321 1.05263
5 4QOS ADP 0.0002319 0.43556 1.13208
6 1SVM ATP 0.001391 0.46101 1.23077
7 3WYA GDP 0.00000000001137 0.67554 1.53846
8 3WY9 GDP 0.0000000001052 0.62819 1.53846
9 1TQ4 GDP 0.00000003558 0.62263 1.53846
10 3IO3 ADP 0.00001046 0.51037 1.53846
11 1X6V ADP 0.0002221 0.47562 1.53846
12 5TSH ANP 0.00004245 0.44556 1.53846
13 2ZR9 DTP 0.00005002 0.4404 1.53846
14 2B8W ALF 5GP 0.001574 0.43178 1.53846
15 5TSH ADP 0.00008865 0.41105 1.53846
16 1NST A3P 0.00333 0.40198 1.53846
17 2CBZ ATP 0.000004074 0.6193 1.68776
18 5M7P ADP 0.0002456 0.45397 1.84615
19 1NN5 ANP 0.0006053 0.45959 1.86047
20 4PX9 ADP 0.000217 0.41496 2.05479
21 3E70 GDP 0.000009999 0.48305 2.15385
22 5I34 GDP 0.00001471 0.47556 2.15385
23 3EZ2 ADP 0.00002189 0.4471 2.15385
24 2C9O ADP 0.0005405 0.44582 2.15385
25 2ZPA ADP 0.001129 0.42644 2.15385
26 4LJ9 ACP 0.0005414 0.41109 2.15385
27 2Z3Y F2N 0.01789 0.40756 2.15385
28 3ZQ6 ADP ALF 0.00001267 0.52619 2.16049
29 5WRI A3P 0.001351 0.43096 2.1875
30 1X1R GDP 0.000001112 0.57211 2.24719
31 5WRJ A3P 0.001288 0.43554 2.31023
32 1Z2A GDP 0.00000008565 0.58224 2.38095
33 4WZ6 ATP 0.00003719 0.41418 2.41379
34 4ZG4 VO4 ADP 0.0006621 0.44609 2.46154
35 1BG2 ADP 0.0000003308 0.44494 2.46154
36 2XT3 ADP 0.000003804 0.43328 2.46154
37 5GJC ATP 0.0002508 0.41346 2.46154
38 2NGR GDP 0.0000009326 0.52477 2.6178
39 1A4R GDP 0.00001527 0.5053 2.6178
40 1A4R GNH 0.00001057 0.50502 2.6178
41 2WMO GTP 0.000002201 0.51648 2.63158
42 2Z5F A3P 0.005655 0.40266 2.68456
43 2QQ0 TMP 0.002232 0.43586 2.71739
44 2QQ0 ANP 0.002337 0.43497 2.71739
45 2QQ0 THM 0.002315 0.43239 2.71739
46 2RCN GDP 0.00000001555 0.57312 2.76923
47 3EC1 GDP 0.00000005698 0.56666 2.76923
48 1E2K TMC 0.0009064 0.46221 2.76923
49 2BIF ANP 0.001462 0.44538 2.76923
50 2BIF SIN 0.002486 0.44538 2.76923
51 3DZD ADP 0.0003804 0.43509 2.76923
52 2VF7 ADP 0.0003812 0.41872 2.76923
53 5LB3 ADP 0.0002621 0.41346 2.76923
54 2PEZ DAT 0.0001384 0.48954 2.7933
55 2PEZ GGZ 0.0001384 0.48954 2.7933
56 3BER AMP 0.01305 0.40806 2.81124
57 3P4X ADP 0.00002834 0.44322 2.90557
58 2FFQ GSP 0.0000005812 0.58436 2.92398
59 3FKQ ATP 0.0003243 0.44344 2.94906
60 1GRN GDP 0.000006158 0.51499 2.95567
61 1U0J ADP 0.0003076 0.41005 2.99625
62 3BFX A3P 0.0008922 0.43121 3.04054
63 2PZE ATP 0.000008906 0.41847 3.05677
64 5HCN GCP 0.000002251 0.51504 3.06513
65 1V8K ANP 0.00005517 0.4392 3.07692
66 4LYA ATP 0.0001251 0.43789 3.07692
67 1G41 ADP 0.0003011 0.43131 3.07692
68 5MVR ADP 0.0000125 0.46911 3.08642
69 3H86 AP5 0.004673 0.42407 3.125
70 4D81 ADP 0.00008516 0.45902 3.18021
71 1NJF ADP 0.0001145 0.46777 3.2
72 1NJF AGS 0.000249 0.46221 3.2
73 1B7T ADP 0.000548 0.41901 3.20513
74 4P32 ADP 0.002805 0.41745 3.21285
75 4DID GDP 0.000001592 0.51506 3.28947
76 2C04 GCP 0.00003617 0.50644 3.367
77 5M04 GDP 0.0000000005231 0.6065 3.38462
78 4IEE AGS 0.001116 0.46549 3.38462
79 4PFO ADP 0.0004475 0.45714 3.38462
80 3LRE ADP 0.000001797 0.42916 3.38462
81 1XP8 AGS 0.000114 0.41964 3.38462
82 2QZ4 ADP 0.00006467 0.45602 3.43511
83 1OE0 TTP 0.004823 0.414 3.47826
84 3B7G ANP 0.001076 0.40678 3.47826
85 1G8S MET 0.02374 0.40631 3.47826
86 2GJ8 ALF GDP 0.0000003369 0.59465 3.48837
87 3UIE ANP 0.00007247 0.45277 3.5
88 5TIV A3P 0.01684 0.40702 3.55731
89 1SQ5 ADP 0.00002015 0.46648 3.57143
90 1KK8 BEF ADP 0.0004995 0.43416 3.59712
91 1VHT BA3 0.0003248 0.43178 3.66972
92 1GOJ ADP 0.000001956 0.63627 3.69231
93 1QF5 GDP 0.00003271 0.53909 3.69231
94 1QF5 RPL 0.003942 0.4705 3.69231
95 5IFS ADP 0.0001633 0.44162 3.69231
96 1R6B ADP 0.0003108 0.42583 3.69231
97 4HSE ADP 0.0002794 0.42249 3.69231
98 3TMK T5A 0.0004327 0.46291 3.7037
99 1JI0 ATP 0.0000192 0.56145 3.75
100 2OFW ADX 0.0001841 0.49249 3.84615
101 4FCW ADP 0.0001921 0.43399 3.85852
102 5BYK OAQ 0.01412 0.40673 3.861
103 5BYK A3P 0.01412 0.40673 3.861
104 3A1S GDP 0.000002548 0.50774 3.87597
105 2ZTS ADP 0.0009108 0.44032 3.98406
106 1IHU AF3 0.00004066 0.49569 4
107 1IHU ADP 0.00004635 0.49551 4
108 1P9B GDP 0.0000251 0.4888 4
109 3A4M ADP 0.000005389 0.45166 4
110 4R98 GNH 0.0000000009875 0.61986 4.05904
111 1H65 GDP 0.00013 0.47422 4.07407
112 3DKP ADP 0.0006426 0.40795 4.08163
113 5X40 ACP 0.003067 0.41759 4.10959
114 1ION ADP 0.000006858 0.49288 4.11523
115 3REF GDP 0.000007611 0.52664 4.12371
116 4NON GDP 0.00000007624 0.6252 4.23077
117 2WJG GDP 0.00000000009176 0.80314 4.25532
118 1PUJ GNP 0.000000002145 0.63814 4.25532
119 2XTN GTP 0.0001742 0.47091 4.2735
120 1G6H ADP 0.000002334 0.42328 4.28016
121 5VGR GDP 0.0002854 0.4466 4.30769
122 5BR7 FAD 0.02925 0.40888 4.3257
123 4GOX A3P 0.0005814 0.44851 4.47284
124 1S3G AP5 0.0007935 0.46484 4.60829
125 2AWN ADP 0.000001005 0.41658 4.61538
126 2JLR ANP 0.00138 0.40916 4.61538
127 4OHY ANP 0.002242 0.40092 4.61538
128 4GBM A3P 0.00149 0.43101 4.64396
129 2WJH GDP 0.000000002415 0.6114 4.81928
130 2WJH FLC 0.0000003966 0.54199 4.81928
131 2CHG ANP 0.000256 0.44712 4.86726
132 4LC1 GDP 0.0000001826 0.64334 4.92308
133 1P72 ADP 0.001995 0.43803 4.92308
134 5CK5 GDP 0.0000001983 0.52808 5.06329
135 1HTW ADP 0.000007788 0.48302 5.06329
136 1L2T ATP 0.001336 0.43485 5.10638
137 1QF9 ADP 0.001839 0.44472 5.15464
138 1QF9 ALF 0.001839 0.44472 5.15464
139 1QF9 C5P 0.001839 0.44472 5.15464
140 1UJ2 C5P 0.0001185 0.48399 5.15873
141 1UJ2 ADP 0.0001686 0.47734 5.15873
142 3WXM GTP 0.0000001959 0.60239 5.23077
143 2XAU ADP 0.0004039 0.4253 5.23077
144 2HF9 GSP 0.00000003764 0.63805 5.30973
145 4WOP CTP 0.001836 0.42335 5.33333
146 1JJ7 ADP 0.000001305 0.42804 5.38462
147 3BFV ADP 0.00001139 0.46722 5.55556
148 3TKL GTP 0.000001987 0.5565 5.61225
149 5J1J ANP 0.00004935 0.49434 5.61404
150 4YDS ATP 0.00005065 0.42074 5.70175
151 4U00 ADP 0.000002123 0.42446 5.7377
152 4E03 ADP 0.00001684 0.47264 5.82524
153 1ZRH A3P 0.005691 0.40255 5.83942
154 5KSZ GCP 0.00002749 0.47862 5.84615
155 1XMV ADP 0.00005902 0.44497 5.84615
156 4ZLU ADP 0.01122 0.40809 5.84615
157 4ZLU 4PW 0.01122 0.40809 5.84615
158 5L3W GDP 0.0001535 0.44842 5.88235
159 1VKJ A3P 0.004707 0.40604 5.96491
160 2KIN ADP 0.0000005574 0.43891 6
161 3FB4 AP5 0.0009606 0.46106 6.01852
162 2F9L GDP 0.0000008427 0.56997 6.03015
163 3SFV GDP 0.0000005584 0.57207 6.07735
164 4KFU ACP 0.00001198 0.43375 6.13208
165 4RD0 GDP 0.00000008672 0.60931 6.15385
166 2DPY ADP 0.0005194 0.48837 6.15385
167 4R43 GDP 0.0001968 0.42713 6.15385
168 1XTQ GDP 0.0000002576 0.59199 6.21469
169 1OIV GDP 0.0000002288 0.59947 6.28272
170 1OIX GDP 0.0000009121 0.5735 6.28272
171 3NKV GNP 0.000003512 0.54818 6.28571
172 1KO8 6PG 0.0008727 0.43145 6.28571
173 3KJI ADP 0.0001029 0.4566 6.29921
174 3TNF GNP 0.000002723 0.55738 6.32184
175 4LHW GNP 0.000003888 0.54627 6.32184
176 3QBT GNP 0.000001455 0.51588 6.32184
177 1Z06 GNP 0.0000004479 0.58434 6.34921
178 3W5J GDP 0.0000002921 0.47708 6.37255
179 1UKZ ADP 0.001433 0.44577 6.40394
180 2W58 ADP 0.00001264 0.40707 6.43564
181 1ZIN AP5 0.001463 0.45273 6.45161
182 1SKQ GDP 0.00000000003589 0.64209 6.46154
183 3DEF GDP 0.00003535 0.47384 6.46154
184 1G16 GDP 0.000007676 0.52649 6.47059
185 3RWO GDP 0.0000006233 0.58065 6.48649
186 3RAB GNP 0.000001127 0.56953 6.50888
187 1M7G ADX 0.0002425 0.47718 6.63507
188 1M7G AV2 0.000003625 0.47448 6.63507
189 1M7G ADP 0.0003174 0.46881 6.63507
190 5K5Z ANP 0.0002312 0.46764 6.6879
191 1DAK DPU 0.002291 0.44599 6.69643
192 1Z0F GDP 0.00000002185 0.58406 6.70391
193 5JCZ GDP 0.000001644 0.54433 6.70391
194 2OZE AGS 0.0002276 0.45579 6.71141
195 1VG8 GNP 0.0000005299 0.58611 6.76329
196 5FTB ANP 0.0003026 0.47596 6.76923
197 1K6M AGS 0.0002736 0.46252 6.76923
198 5FHD ADP ALF 0.0005925 0.44413 6.76923
199 5LTJ ADP 0.0001288 0.43368 6.76923
200 3RLF ANP 0.001801 0.42749 6.76923
201 1JJV ATP 0.0000109 0.43826 6.79612
202 2HV8 GTP 0.000002473 0.55477 6.97674
203 4TTQ ATP 0.00009063 0.44087 6.97674
204 1W4R TTP 0.006402 0.4101 7.07692
205 5G41 AP5 0.0004671 0.48099 7.17489
206 2D7C GTP 0.000001066 0.57057 7.18563
207 3GJ0 GDP 0.00000001976 0.69012 7.23982
208 3GJ3 GDP 0.000000007668 0.58797 7.23982
209 4ZNL BEF ADP 0.00004865 0.45099 7.29927
210 1WF3 GNP 0.0000005674 0.58482 7.30897
211 4B47 GDP 0.0000000002843 0.61631 7.38462
212 1FNN ADP 0.0002408 0.45464 7.38462
213 1F9V ADP 0.00001237 0.43137 7.38462
214 3CH5 GDP 0.00000001391 0.58928 7.40741
215 5BXQ GDP 0.00000001612 0.58758 7.40741
216 1D5C GDP 0.0000005303 0.55742 7.40741
217 1UAD GNP 0.0000008237 0.57541 7.42857
218 4LPS GDP 0.00000004418 0.56789 7.43802
219 1G7C 5GP 0.00000003439 0.55998 7.44681
220 1TU3 GNP 0.000001464 0.56461 7.60234
221 4QM7 GTP 0.0000153 0.46304 7.60234
222 2A9K GDP 0.0000001226 0.58225 7.62332
223 1R2Q GNP 0.0000003958 0.60649 7.64706
224 3Q85 GNP 0.000000006177 0.58817 7.69231
225 1U8Z GDP 0.00000005193 0.62175 7.7381
226 3MJH GTP 0.000001141 0.56929 7.7381
227 1S8F GDP 0.00000008101 0.62405 7.9096
228 4ITR GDP 0.000003871 0.5297 7.91139
229 2FH5 GTP 0.0000002028 0.59067 7.94393
230 4BQS ADP 0.000007908 0.56406 7.95455
231 4BQS K2Q 0.0004067 0.47297 7.95455
232 4YC7 GNP 0.00000314 0.543 8
233 2WOJ ADP ALF 0.00004269 0.50326 8
234 4XVU ATP 0.00006013 0.49067 8
235 1G3Q ADP 0.000001772 0.50616 8.01688
236 1LVG ADP 0.000002265 0.46715 8.08081
237 1D2N ANP 0.003065 0.41393 8.08823
238 4JLV ADP 0.0004198 0.40562 8.17844
239 5WDR GNP 0.0000005379 0.58582 8.18713
240 5XCO GDP 0.0000003892 0.55515 8.18713
241 1Z08 GNP 0.000000706 0.57326 8.23529
242 1YVD GNP 0.000004806 0.54229 8.28402
243 4J0Q GDP 0.0000000001437 0.62483 8.33333
244 1KK1 GNP 0.0000000002912 0.6164 8.33333
245 4KVG GTP 0.000001711 0.56168 8.33333
246 5H56 ADP 0.0002232 0.47717 8.33333
247 5H56 TYD 0.0002232 0.47717 8.33333
248 3Q9L ATP 0.0003986 0.44042 8.33333
249 1T5C ADP 0.0000008999 0.43444 8.33333
250 1W5T ANP 0.001307 0.4296 8.33333
251 3EWA ANP 0.000109 0.42773 8.33333
252 3QKT ANP 0.002204 0.42549 8.33333
253 1W5T ADP 0.002305 0.40905 8.33333
254 4CVN ADP 0.00002574 0.43455 8.37696
255 1CLU DBG 0.0000007136 0.60684 8.43373
256 5UFQ GNP 0.0000007698 0.57668 8.43373
257 5IRR GSP 0.00004474 0.49392 8.44156
258 4DSU GDP 0.0000006025 0.58368 8.46561
259 5SZH GNP 0.000001888 0.56212 8.49673
260 1JWY GDP 0.0000001161 0.57278 8.61539
261 2WKQ GTP 0.00001465 0.49563 8.61539
262 1JWY ADP 0.0001469 0.43241 8.61539
263 2HT6 GDP 0.0000000008668 0.60026 8.62069
264 1OFH ADP 0.0003629 0.42921 8.62069
265 1F2U ATP 0.003288 0.42124 8.72483
266 1KAO GDP 0.00000007459 0.59115 8.98204
267 3X1Z GNP 0.0000008777 0.57886 8.98204
268 4HDO GNP 0.000001226 0.57027 8.98204
269 4HDQ GNP 0.000001844 0.56257 8.98204
270 1GUA GNP 0.000001166 0.51299 8.98204
271 3E5H GNP 0.0000005221 0.58398 8.98876
272 4U5X GNP 0.000007691 0.51739 8.98876
273 2CJW GDP 0.00000000185 0.60634 9.375
274 5JCP GDP ALF 0.00000447 0.51988 9.53846
275 3BC1 GNP 0.000001354 0.56608 9.74359
276 4LX0 BEF GDP 0.000001691 0.5642 10.1538
277 1NF3 GNP 0.000009514 0.52946 10.1562
278 3CPJ GDP 0.000001274 0.53515 10.3139
279 1ZC3 GNP 0.0000001485 0.61012 10.6195
280 4DCT GDP 0.00000009369 0.5605 10.7692
281 2WHX ADP 0.00004356 0.41249 10.7692
282 1IBR GNP 0.0000002973 0.59701 11.1111
283 5L3S GNP 0.00002887 0.50651 11.1111
284 5L3V GDP 0.00001131 0.48971 11.1111
285 1YTM ATP 0.00005419 0.48806 11.1111
286 5N69 ADP 0.0001665 0.44679 11.1111
287 3FYH ADP 0.001657 0.43083 11.1111
288 3NHB ADP 0.00001761 0.42596 11.1111
289 2GDJ ANP 0.0002435 0.41832 11.1111
290 5UQW GDP 0.0000006358 0.57779 11.3846
291 5O2T GSP 0.000001437 0.56727 11.3846
292 1VG1 GDP 0.00000002276 0.57936 11.8919
293 1Z0A GDP 0.00000002217 0.59101 12.069
294 3KTA AP5 0.0003137 0.43441 12.0879
295 1XEX ATP 0.001751 0.43151 12.0879
296 2ZE7 DST 0.003888 0.41807 12.253
297 5E95 GDP 0.00000007178 0.59327 12.6154
298 1NVV GNP 0.000001016 0.57382 12.6154
299 3DDC GNP 0.000001168 0.5712 12.6154
300 1WQ1 GDP 0.0000008799 0.56917 12.6154
301 2UZI GTP 0.000001311 0.56668 12.6154
302 1KY3 GDP 0.0000006807 0.54142 12.6374
303 2C5L GTP 0.000001194 0.57077 12.8205
304 1NVU GTP 0.000001138 0.57168 12.9231
305 4TMK T5A 0.004906 0.4219 13.615
306 1NRJ GTP 0.0000005356 0.57284 13.7615
307 1RYH GNP 0.000001726 0.52177 13.7931
308 5GOE GDP 0.000000001956 0.62759 13.8889
309 4HAT GNP 0.0000002659 0.60151 13.8889
310 5UWP GNP 0.0000002769 0.60074 13.8889
311 5DIF GNP 0.000000252 0.60014 13.8889
312 5UWW GNP 0.00000028 0.59815 13.8889
313 5UWI GNP 0.0000003057 0.59649 13.8889
314 5DHF GNP 0.0000003164 0.59584 13.8889
315 5DI9 GNP 0.0000003932 0.59409 13.8889
316 5UWT GNP 0.0000003535 0.59375 13.8889
317 5UWH GNP 0.0000006152 0.58329 13.8889
318 5UWJ GNP 0.0000003606 0.52883 13.8889
319 4MKG AP5 0.0009338 0.46162 13.8889
320 2CE7 ADP 0.00009774 0.44866 13.8889
321 3ZFD ANP 0.0002167 0.43356 13.8889
322 1KMQ GNP 0.00001113 0.52202 14.1304
323 5XDR ADP 0.000467 0.41665 14.1538
324 4XOI GTP 0.000005964 0.53597 14.4444
325 3Q72 GNP 0.000000008663 0.57124 14.4578
326 1XKV ATP 0.00004837 0.46326 14.4615
327 1B0U ATP 0.0006976 0.42074 14.5038
328 1DS6 GDP 0.0000004953 0.52628 14.5833
329 1E96 GTP 0.00001626 0.51939 14.5833
330 3KUD GDP 0.0000002664 0.58566 14.8148
331 4C4P GNP 0.000001525 0.56616 14.9533
332 5UWU GNP 0.000000269 0.59891 15
333 1Z0J GTP 0.000004313 0.54653 15.2542
334 3GJ8 GDP 0.00000001662 0.68289 15.3846
335 3GJ5 GDP 0.00000001834 0.58532 15.3846
336 3GJ7 GDP 0.00000001579 0.57849 15.3846
337 3GJ4 GDP 0.00000002736 0.57104 15.3846
338 2QG6 NMN 0.0005303 0.4574 15.5779
339 2IS6 ADP 0.0001518 0.42541 15.6923
340 4D0G GTP 0.0000004124 0.5805 15.942
341 1Y63 ADP 0.000003008 0.48391 16.3043
342 4HI0 GDP 0.000000006826 0.65295 16.6667
343 2C77 GNP 0.00000001923 0.63393 16.6667
344 2C78 GNP 0.00000003518 0.62598 16.6667
345 4P3Y GDP 0.0000000002961 0.61565 16.6667
346 5JBQ GDP 0.000000000877 0.61479 16.6667
347 4G5G GDP 0.000000001049 0.61292 16.6667
348 2BVN GNP 0.00000001025 0.61265 16.6667
349 3U6B GDP 0.0000000004158 0.61241 16.6667
350 1D8T GDP 0.000000001134 0.61051 16.6667
351 2HCJ GDP 0.0000000008457 0.60427 16.6667
352 4PC3 GDP 0.00000002237 0.60254 16.6667
353 3U6K GDP 0.00000000282 0.60003 16.6667
354 2ZEJ GDP 0.0000003369 0.59466 16.6667
355 2EFE GNH 0.0000006046 0.54761 16.6667
356 1IWE IMP 0.000535 0.51104 16.6667
357 5IRC GDP 0.00001356 0.48769 16.6667
358 4RZ3 ADP 0.0001122 0.46351 16.6667
359 3ZIA ADP 0.00006581 0.4625 16.6667
360 4MKF AP5 0.001021 0.46099 16.6667
361 5IRN ADP 0.00007395 0.4599 16.6667
362 3ZIA ATP 0.00004819 0.45138 16.6667
363 2FNA ADP 0.0002746 0.44978 16.6667
364 3COB ADP 0.000003654 0.43722 16.6667
365 5HR5 ADP 0.0004509 0.43607 16.6667
366 3H4S ADP 0.000002836 0.43464 16.6667
367 4FRZ ADP 0.000009562 0.43378 16.6667
368 2Q2Y MKR 0.004085 0.4313 16.6667
369 2Q2Y ADP 0.004313 0.4313 16.6667
370 5I0H ADP BEF 0.001315 0.42949 16.6667
371 5J1S ATP 0.002173 0.42576 16.6667
372 1NHX FTB 0.006965 0.4257 16.6667
373 1NHX PEP 0.006699 0.42554 16.6667
374 4YMU ATP 0.00008112 0.4223 16.6667
375 1T8U UAP SGN IDS SGN 0.006814 0.42222 16.6667
376 1NY5 ADP 0.001091 0.42189 16.6667
377 1T8U A3P 0.002307 0.41915 16.6667
378 1YQT ADP 0.00003628 0.41715 16.6667
379 2ZPT A3P 0.01831 0.41338 16.6667
380 4PPF FLC 0.000003583 0.40953 16.6667
381 2PL3 ADP 0.0004078 0.40641 16.6667
382 2GMV PEP 0.009036 0.40626 16.6667
383 2GMV UN8 0.008146 0.40551 16.6667
384 4PJ3 ANP 0.002478 0.40348 16.6667
385 3LXR GDP 0.000003004 0.56843 16.7568
386 1CXZ GSP 0.000008467 0.52468 17.033
387 4DKX GDP 0.00000001234 0.70002 17.1296
388 4XSH GSP 0.000009549 0.51345 17.3184
389 3BOS CDP 0.000006332 0.47203 17.3554
390 1TX4 ALF GDP 0.00001891 0.49084 17.5141
391 3T1O GDP 0.00000000002044 0.69942 17.6768
392 3T12 GDP ALF 0.0000000007317 0.69753 17.6768
393 3IIJ ADP 0.000003878 0.48262 17.7778
394 1SVI GDP 0.0000008929 0.50983 17.9487
395 1LFD GNP 0.0000007488 0.57721 18.3908
396 4ZI2 GNP 0.00000008569 0.60953 18.4211
397 4GOJ GNP 0.00000003328 0.62701 18.5185
398 5UWR GNP 0.0000003335 0.59484 18.5185
399 4XTR ADP 0.00003231 0.49014 18.9189
400 4XTR ATP 0.00006218 0.49005 18.9189
401 1FZQ GDP 0.0000000008162 0.61501 19.337
402 2GCN GDP 0.000009657 0.52225 19.403
403 2GCO GNP 0.000004252 0.52091 19.403
404 3VMF GTP 0.00000007792 0.6197 19.4444
405 3B9Q MLI 0.000007634 0.59456 19.4444
406 1WDT GTP 0.000000258 0.59353 19.4444
407 3CNL GNP 0.000000001842 0.58682 19.4444
408 4D0N GDP 0.0000004102 0.52639 19.4444
409 3T34 GDP 0.000002657 0.52261 19.4444
410 5L3R GCP 0.00001853 0.51479 19.4444
411 3FWY ADP 0.00002143 0.49153 19.4444
412 5BQ5 ADP BEF 0.0001565 0.44183 19.4444
413 4BFW ZVW 0.00269 0.44066 19.4444
414 4IOK ADP 0.001675 0.43557 19.4444
415 2IXE ATP 0.001176 0.43352 19.4444
416 4IOK XPO 0.001472 0.43303 19.4444
417 3FVQ ATP 0.001303 0.42966 19.4444
418 2VVG ADP 0.000002188 0.42594 19.4444
419 1ZJ6 G3D 0.00000000004308 0.67194 20.3209
420 3DOE GTP 0.000000008861 0.6546 20.8333
421 4OI4 ATP 0.000453 0.45315 20.8696
422 5DI3 GNP 0.00000002374 0.63324 21.0811
423 1KSH GDP 0.00000003505 0.62291 21.5054
424 3T5G GDP 0.00000005351 0.57758 21.7105
425 5TB5 GDP 0.00000003665 0.58467 22
426 1G7S GDP 0.0000000008361 0.74425 22.2222
427 4BAS GNP 0.000000007104 0.65553 22.2222
428 1D2E GDP 0.000000005149 0.62502 22.2222
429 4K81 GTP 0.0000003172 0.59816 22.2222
430 2A5J GDP 0.000000111 0.56659 22.2222
431 1YZN GNP 0.000003531 0.55031 22.2222
432 2BCG GDP 0.000001722 0.54443 22.2222
433 1EK0 GNP 0.000005114 0.54112 22.2222
434 2EW1 GNP 0.000004323 0.53959 22.2222
435 4H1V GNP 0.000001603 0.53894 22.2222
436 2ZFI ADP 0.00006278 0.52048 22.2222
437 1ZUI SKM 0.001418 0.44857 22.2222
438 1IN4 ADP 0.000433 0.44389 22.2222
439 1Z6T ADP 0.0006317 0.4302 22.2222
440 3B5J 12D 0.00002918 0.42977 22.2222
441 5TAR GDP 0.00000006063 0.58413 22.2973
442 1YZG GDP 0.00000000002413 0.67954 22.3464
443 5UWQ GNP 0.0000002833 0.53248 22.7273
444 4V0K GDP 0.000000009966 0.65543 23.0769
445 1ZD9 GDP 0.00000002731 0.63564 23.4043
446 1M2O GNP 0.0000003238 0.59295 23.6842
447 5KUT GDP 0.000000282 0.54246 23.8095
448 1MR3 G3D 0.0000000001102 0.65801 24.3094
449 2X77 GDP 0.00000006482 0.56478 24.8677
450 4M9Q GNP 0.00000002254 0.63421 25
451 1WA5 GTP 0.000000431 0.59889 25
452 3MD0 GDP 0.0000000008824 0.59839 25
453 4TMZ GSP 0.0000005682 0.57729 25
454 4NCN GTP 0.0000007046 0.5733 25
455 3TK1 GDP 0.0000000173 0.54969 25
456 4Q1A UDP 0.001446 0.50461 25
457 4Q1A 2XZ 0.001446 0.50461 25
458 1OS1 PYR 0.0001077 0.49113 25
459 1OS1 ATP 0.00009839 0.49113 25
460 3PQC GDP 0.00001712 0.48521 25
461 1W7J ADP BEF 0.0001882 0.47483 25
462 2BEK ATP 0.000764 0.46319 25
463 1W0J ADP 0.00007233 0.46057 25
464 2Y65 ADP 0.000001502 0.44417 25
465 1Z83 AP5 0.001992 0.43939 25
466 1CR1 TTP 0.001094 0.43287 25
467 1W0J ADP BEF 0.001075 0.42751 25
468 1R0X ATP 0.0001337 0.42144 25
469 3QF7 ANP 0.002068 0.41545 25
470 3R7F CP 0.01909 0.4109 25
471 4IV9 FAD 0.01675 0.40622 25
472 1VG9 GDP 0.00000006261 0.56485 25.2308
473 1VG0 GDP 0.000000232 0.56309 25.2308
474 1F6B GDP 0.000000002275 0.61171 25.2525
475 1UPT GTP 0.00000006704 0.61407 25.731
476 2BME GNP 0.0000003446 0.59178 25.8065
477 2VB6 ADP BEF 0.0003891 0.45597 26.1745
478 3ZS9 ADP ALF 0.00006793 0.4945 26.3158
479 5EE5 GTP 0.0000002469 0.58998 26.9006
480 2QTV GNP 0.0000003489 0.589 26.9461
481 3AQ4 GDP 0.00000000001059 0.69143 27.1739
482 4YLG GDP 0.0000000003694 0.68178 27.7457
483 5FG3 GDP 0.000000000989 0.60052 27.7778
484 1YRB GDP 0.0000001384 0.57179 27.7778
485 4AG5 ADP 0.00004619 0.54807 27.7778
486 4P4T GDP 0.000002183 0.53966 27.7778
487 4XGU ADP 0.00005107 0.47655 27.7778
488 2QEN ADP 0.0001156 0.45955 27.7778
489 1RRC ADP 0.000001239 0.44455 27.7778
490 1G6O ADP 0.0001521 0.44036 27.7778
491 1XX6 ADP 0.000364 0.40754 27.7778
492 2A5F GTP 0.0000000002728 0.72265 28
493 4KAX GTP 0.000000005322 0.66087 28.4024
494 1R4A GNP 0.000000006022 0.66484 28.4848
495 1I4D GDP 0.0000007994 0.51287 28.6458
496 2W83 GTP 0.000000002269 0.67991 29.0909
497 3SBD GNP 0.00002996 0.50792 29.4118
498 1MH1 GNP 0.000004248 0.54682 29.5699
499 1G4U GDP 0.000001332 0.54969 29.8913
500 3N5C GDP 0.00000000001808 0.83732 30.2469
501 3PCR GTP 0.000000007499 0.62204 30.2469
502 2NCD ADP 0.000002982 0.61028 30.5556
503 3WYG GTP 0.0000002038 0.60655 30.5556
504 3WYF GTP 0.0000002591 0.602 30.5556
505 3M1I GTP 0.0000003653 0.59313 30.5556
506 4NE2 ADP 0.0004077 0.47155 30.5556
507 4NE2 SH2 0.0005011 0.47021 30.5556
508 3DC4 ADP 0.00002937 0.42768 30.5556
509 1OXV ANP 0.00006018 0.42619 30.5556
510 1G3M A3P 0.01472 0.40591 30.5556
511 1G3M PCQ 0.01472 0.40591 30.5556
512 2FJU GSP 0.000008668 0.52172 30.8989
513 1HE1 GDP 0.00000193 0.5493 31.25
514 1HE1 AF3 0.01835 0.40918 31.25
515 2J0V GDP 0.000002897 0.50761 32.5472
516 1Z0K GTP 0.0000008779 0.56921 33.1395
517 1S9D GDP 0.000000000007802 0.84021 33.3333
518 1O3Y GTP 0.00000000326 0.67318 33.3333
519 2J59 GTP 0.000000004035 0.66922 33.3333
520 1RE0 GDP 0.000000000009499 0.65683 33.3333
521 1MKY GDP 0.00000000007634 0.65158 33.3333
522 1J2J GTP 0.00000006823 0.58533 33.3333
523 4X8O AP5 0.0002151 0.49658 33.3333
524 4V03 ADP 0.00001179 0.48597 33.3333
525 2RGX AP5 0.0006713 0.47046 33.3333
526 1FP6 ADP 0.00006374 0.46493 33.3333
527 2V7Q ATP 0.00005115 0.45805 33.3333
528 3QXC ATP 0.0005383 0.45542 33.3333
529 2FAH GDP 0.0002067 0.44686 33.3333
530 4IDN GNP 0.001038 0.43583 33.3333
531 2CK3 ADP 0.001683 0.42875 33.3333
532 2CK3 ANP 0.001257 0.4248 33.3333
533 2V7Q ADP 0.0002196 0.42174 33.3333
534 2VOH CIT 0.01481 0.42387 34.6154
535 3GJX GTP 0.0000006221 0.58308 36.1111
536 1OW3 GDP 0.000004847 0.51946 36.1111
537 4IHQ ADP 0.00002744 0.44532 36.1111
538 2W2X GSP 0.000009457 0.52012 38.7097
539 2G77 GDP 0.00000005679 0.5961 38.8889
540 5HPY GDP 0.000003198 0.52624 38.8889
541 3VX3 ADP 0.00004651 0.4845 38.8889
542 5UWS GNP 0.0000003378 0.59697 40.9091
543 1RJ9 GCP 0.00008879 0.51199 41.6667
544 2IYL GDP 0.000018 0.467 41.6667
545 2QN6 GDP 0.0000000004438 0.61201 44.4444
546 1M7B GTP 0.000005395 0.53042 44.4444
547 1GWN GTP 0.000006374 0.52736 44.4444
548 5UWO GNP 0.0000003348 0.59477 45
549 2WIC GNP 0.0000000001853 0.77519 50
550 4ZKD GDP 0.00000002531 0.64351 50
551 1DAR GDP 0.0000000002572 0.62866 50
Pocket No.: 2; Query (leader) PDB : 2OM2; Ligand: GDP; Similar sites found: 5
This union binding pocket(no: 2) in the query (biounit: 2om2.bio1) has 24 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1PVN MZP 0.01161 0.40966 3.69231
2 2OFD NGA 0.01364 0.41717 6.33803
3 1DAK ADP 0.04039 0.41069 6.69643
4 2JJK R15 0.02107 0.40151 7.07692
5 2YOH WMJ 0.0003083 0.40216 7.61905
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