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Receptor
PDB id Resolution Class Description Source Keywords
3R1K 1.95 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ACETYLTRANSFERASE EIS FROM MYCOBACTERIU TUBERCULOSIS H37RV IN COMPLEX WITH COA AND AN ACETAMIDE MOI MYCOBACTERIUM TUBERCULOSIS GNAT ACETYLTRANSFERASE TRANSFERASE
Ref.: UNUSUAL REGIOVERSATILITY OF ACETYLTRANSFERASE EIS, OF DRUG RESISTANCE IN XDR-TB. PROC.NATL.ACAD.SCI.USA V. 108 9804 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACM A:403;
Valid;
none;
submit data
59.067 C2 H5 N O CC(=O...
COA A:500;
Valid;
none;
submit data
767.534 C21 H36 N7 O16 P3 S CC(C)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5TVJ 2.3 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ACETYLTRANSFERASE EIS FROM MYCOBACTERIU TUBERCULOSIS IN COMPLEX WITH COA AND INHIBITOR 2K*: 1-(4- F LUOROPHENYL)-2-[2-(4-METHYLPHENYL)-2-OXOETHYL]PYRROLO[1,2-2- IUM MYCOBACTERIUM TUBERCULOSIS TRANSFERASE ACETYLTRANSFERASE RESISTANCE AMINOGLYCOSIDE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: COMBATING ENHANCED INTRACELLULAR SURVIVAL (EIS)-MED KANAMYCIN RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS PYRROLO[1,5-A]PYRAZINE-BASED EIS INHIBITORS. ACS INFECT DIS V. 3 302 2017
Members (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 5EBV ic50 = 0.238 uM 5LR C22 H24 Cl N3 O2 S CC1=C(S(=O....
2 5TVJ ic50 = 0.08 uM 7LF C22 H18 F N2 O Cc1ccc(cc1....
3 5EC4 ic50 = 0.234 uM 5LQ C17 H22 Cl N3 O3 S CC1=C(S(=O....
4 5IV0 ic50 = 5.8 uM 6E9 C16 H15 N3 O5 S CN(c1cccc(....
5 6B3T Ki = 0.16 uM CJ7 C17 H20 F N5 S Cn1c2ccc(c....
6 3R1K - COA C21 H36 N7 O16 P3 S CC(C)(CO[P....
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 3SXN - COA C21 H36 N7 O16 P3 S CC(C)(CO[P....
2 5EBV ic50 = 0.238 uM 5LR C22 H24 Cl N3 O2 S CC1=C(S(=O....
3 5TVJ ic50 = 0.08 uM 7LF C22 H18 F N2 O Cc1ccc(cc1....
4 5EC4 ic50 = 0.234 uM 5LQ C17 H22 Cl N3 O3 S CC1=C(S(=O....
5 5IV0 ic50 = 5.8 uM 6E9 C16 H15 N3 O5 S CN(c1cccc(....
6 6B3T Ki = 0.16 uM CJ7 C17 H20 F N5 S Cn1c2ccc(c....
7 3R1K - COA C21 H36 N7 O16 P3 S CC(C)(CO[P....
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 3SXN - COA C21 H36 N7 O16 P3 S CC(C)(CO[P....
2 5EBV ic50 = 0.238 uM 5LR C22 H24 Cl N3 O2 S CC1=C(S(=O....
3 5TVJ ic50 = 0.08 uM 7LF C22 H18 F N2 O Cc1ccc(cc1....
4 5EC4 ic50 = 0.234 uM 5LQ C17 H22 Cl N3 O3 S CC1=C(S(=O....
5 5IV0 ic50 = 5.8 uM 6E9 C16 H15 N3 O5 S CN(c1cccc(....
6 6B3T Ki = 0.16 uM CJ7 C17 H20 F N5 S Cn1c2ccc(c....
7 3R1K - COA C21 H36 N7 O16 P3 S CC(C)(CO[P....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ACM; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 ACM 1 1
2 PYM 0.636364 0.6875
3 ROP 0.5 0.6875
4 TAY 0.461538 0.6875
Ligand no: 2; Ligand: COA; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 COA 1 1
2 0T1 0.894737 0.976744
3 DCA 0.893805 0.954023
4 COS 0.887931 0.977012
5 ETB 0.877193 0.920455
6 AMX 0.871795 0.988235
7 30N 0.871795 0.913979
8 CAO 0.871795 0.965909
9 CMX 0.864407 0.976744
10 SCO 0.864407 0.976744
11 ACO 0.857143 0.965909
12 FCX 0.857143 0.94382
13 FAM 0.857143 0.954545
14 HAX 0.85 0.954545
15 3KK 0.842975 0.977012
16 FYN 0.842975 1
17 SOP 0.836066 0.977012
18 MCD 0.836066 0.954545
19 OXK 0.836066 0.977012
20 CA6 0.836066 0.885417
21 COK 0.836066 0.977012
22 CO6 0.829268 0.977012
23 NMX 0.829268 0.903226
24 1VU 0.829268 0.965909
25 CMC 0.829268 0.977012
26 CAJ 0.822581 0.954545
27 SCD 0.822581 0.976744
28 2MC 0.822581 0.934066
29 2CP 0.81746 0.965909
30 A1S 0.816 0.977012
31 3HC 0.816 0.988372
32 IVC 0.816 0.988372
33 1HE 0.816 0.955056
34 MLC 0.816 0.977012
35 BCO 0.816 0.977012
36 COD 0.810345 0.988235
37 COO 0.809524 0.977012
38 MCA 0.809524 0.965909
39 CAA 0.809524 0.988372
40 YE1 0.809524 0.965517
41 MC4 0.80315 0.923913
42 SCA 0.80315 0.977012
43 CA8 0.796875 0.885417
44 COF 0.796875 0.955056
45 BYC 0.796875 0.977012
46 COW 0.796875 0.965909
47 3CP 0.796875 0.977012
48 IRC 0.796875 0.988372
49 1GZ 0.796875 0.965909
50 HGG 0.796875 0.977012
51 2KQ 0.796875 0.955056
52 BCA 0.790698 0.965909
53 4CA 0.790698 0.965909
54 FAQ 0.790698 0.977012
55 HXC 0.784615 0.955056
56 GRA 0.784615 0.977012
57 1CV 0.781955 0.977012
58 TGC 0.778626 0.965909
59 2NE 0.772727 0.955056
60 1CZ 0.772727 0.965909
61 CO8 0.772727 0.955056
62 S0N 0.772727 0.954545
63 CIC 0.772727 0.977012
64 DCC 0.766917 0.955056
65 UCC 0.766917 0.955056
66 0FQ 0.766917 0.977012
67 MYA 0.766917 0.955056
68 ST9 0.766917 0.955056
69 4CO 0.766917 0.965909
70 5F9 0.766917 0.955056
71 MFK 0.766917 0.955056
72 01A 0.761194 0.934066
73 0ET 0.761194 0.955056
74 WCA 0.755556 0.955056
75 CS8 0.755556 0.944444
76 UOQ 0.75 0.955056
77 NHW 0.75 0.955056
78 NHM 0.75 0.955056
79 4KX 0.75 0.944444
80 HDC 0.75 0.955056
81 MRR 0.744526 0.955056
82 MRS 0.744526 0.955056
83 HFQ 0.744526 0.955056
84 YNC 0.73913 0.965909
85 DAK 0.73913 0.944444
86 8Z2 0.733813 0.944444
87 NHQ 0.723404 0.988372
88 F8G 0.715278 0.913979
89 1HA 0.713287 0.955056
90 01K 0.708333 0.977012
91 COT 0.703448 0.977012
92 CCQ 0.695652 0.934066
93 CA3 0.693878 0.977012
94 7L1 0.692308 0.965909
95 CA5 0.671053 0.934066
96 UCA 0.666667 0.955056
97 93P 0.666667 0.965909
98 CO7 0.664234 0.977012
99 93M 0.64557 0.965909
100 OXT 0.634146 0.913979
101 5TW 0.607143 0.913979
102 4BN 0.607143 0.913979
103 PAP 0.603604 0.811765
104 JBT 0.598837 0.894737
105 BSJ 0.592814 0.944444
106 HMG 0.581081 0.943182
107 COA PLM 0.573333 0.922222
108 PLM COA 0.573333 0.922222
109 A3P 0.54955 0.8
110 PPS 0.547009 0.752688
111 ASP ASP ASP ILE CMC NH2 0.536585 0.932584
112 0WD 0.521739 0.788889
113 SFC 0.490683 0.955056
114 RFC 0.490683 0.955056
115 191 0.490196 0.865979
116 ACE SER ASP ALY THR NH2 COA 0.483333 0.932584
117 3AM 0.482143 0.788235
118 PTJ 0.48062 0.872093
119 4PS 0.477477 0.682353
120 A22 0.468254 0.813953
121 A2D 0.465517 0.802326
122 PUA 0.462585 0.820225
123 PAJ 0.460938 0.883721
124 ATR 0.459016 0.8
125 SAP 0.459016 0.806818
126 AGS 0.459016 0.806818
127 3OD 0.458015 0.825581
128 ADP 0.453782 0.823529
129 A2R 0.448819 0.813953
130 BA3 0.445378 0.802326
131 OAD 0.442748 0.825581
132 NA7 0.442748 0.858824
133 ATP 0.442623 0.823529
134 HEJ 0.442623 0.823529
135 AP5 0.441667 0.802326
136 B4P 0.441667 0.802326
137 AR6 0.439024 0.802326
138 APR 0.439024 0.802326
139 2A5 0.439024 0.847059
140 5FA 0.439024 0.823529
141 AQP 0.439024 0.823529
142 AN2 0.438017 0.813953
143 AT4 0.438017 0.816092
144 48N 0.435714 0.808989
145 M33 0.434426 0.813953
146 9X8 0.431818 0.806818
147 SRP 0.429688 0.837209
148 ANP 0.428571 0.804598
149 ADQ 0.427481 0.804598
150 YLB 0.426573 0.908046
151 YLP 0.425532 0.886364
152 5AL 0.425197 0.813953
153 7D3 0.425 0.793103
154 AD9 0.424 0.804598
155 APU 0.423611 0.786517
156 7D4 0.422764 0.793103
157 CA0 0.422764 0.804598
158 25L 0.422222 0.813953
159 ATF 0.421875 0.795455
160 F2R 0.421769 0.865169
161 NJP 0.421769 0.806818
162 A2P 0.421488 0.788235
163 A A A 0.421053 0.813953
164 8QN 0.419847 0.813953
165 PNS 0.419643 0.682353
166 ACP 0.419355 0.825581
167 NDP 0.417808 0.788889
168 ACQ 0.417323 0.825581
169 A1R 0.416667 0.882353
170 ATP A A A 0.416058 0.770115
171 A 0.415254 0.8
172 AMP 0.415254 0.8
173 1ZZ 0.414815 0.842697
174 NB8 0.414815 0.808989
175 TXA 0.414815 0.816092
176 FYA 0.414815 0.813953
177 DLL 0.413534 0.793103
178 00A 0.413534 0.758242
179 AHX 0.413534 0.829545
180 PAX 0.412903 0.793478
181 DQV 0.411348 0.813953
182 OMR 0.409722 0.853933
183 9ZD 0.409091 0.818182
184 25A 0.409091 0.802326
185 OOB 0.409091 0.793103
186 9ZA 0.409091 0.818182
187 NPW 0.408163 0.822222
188 6YZ 0.407692 0.825581
189 A A 0.407407 0.781609
190 WAQ 0.407407 0.860465
191 TAT 0.40625 0.816092
192 T99 0.40625 0.816092
193 AMO 0.406015 0.837209
194 4AD 0.406015 0.827586
195 A3R 0.406015 0.882353
196 FA5 0.405797 0.816092
197 YAP 0.405797 0.806818
198 B5Y 0.405797 0.786517
199 TXP 0.405405 0.829545
200 ABM 0.404959 0.781609
201 PRX 0.404762 0.825581
202 ME8 0.404412 0.842697
203 BIS 0.404412 0.818182
204 AFH 0.404255 0.78022
205 J7V 0.403846 0.778947
206 NAI 0.402778 0.777778
207 ODP 0.402685 0.78022
208 DAL AMP 0.401515 0.793103
209 AU1 0.4 0.804598
210 ADX 0.4 0.752688
211 SRA 0.4 0.784091
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5TVJ; Ligand: 7LF; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5tvj.bio1) has 41 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 5TVJ; Ligand: 7LF; Similar sites found with APoc: 246
This union binding pocket(no: 2) in the query (biounit: 5tvj.bio1) has 41 residues
No: Leader PDB Ligand Sequence Similarity
1 5U0L 8YP 1.18483
2 2J5V PCA 1.3624
3 2Y65 ADP 1.36986
4 2F2U M77 1.4218
5 1BG2 ADP 1.53846
6 1MR3 G3D 1.65746
7 4UWJ MYA 1.7199
8 4UWJ 7L5 1.7199
9 1F9V ADP 1.72911
10 5MU6 MYA 1.79028
11 5MU6 KFK 1.79028
12 2AWN ADP 1.83727
13 3BIY 01K 1.84211
14 2ZPA ACO 1.89573
15 5FJJ MAN 1.89573
16 4NON GDP 1.92308
17 4FRZ ADP 2.07254
18 5U32 GDP 2.11864
19 5ZXD ATP 2.1327
20 3VOZ 04A 2.22222
21 2RCN GDP 2.23464
22 3GJ3 GDP 2.26244
23 3GJ4 GDP 2.26244
24 3GJ7 GDP 2.26244
25 3GJ0 GDP 2.26244
26 1T5C ADP 2.29226
27 2XOC ADE 2.29885
28 3CH5 GDP 2.31481
29 1YQT ADP 2.36967
30 2NCD ADP 2.38095
31 3W5J GDP 2.45098
32 1D8T GDP 2.54453
33 2VVG ADP 2.57143
34 1IID NHM 2.60664
35 2XT3 ADP 2.61628
36 3EC1 GDP 2.71003
37 1XP8 AGS 2.73224
38 2OG2 MLI 2.78552
39 4AG5 ADP 2.80612
40 1GOJ ADP 2.8169
41 3SZB I1E 2.8436
42 1XMV ADP 2.8436
43 2XAU ADP 2.8436
44 5CK5 GDP 2.8481
45 5HGZ ACO 2.88066
46 5GVR LMR 2.99145
47 4H6U ACO 3
48 4B5P ACO 3
49 3E70 GDP 3.04878
50 2GKS ADP 3.08057
51 4UCI ADN 3.08057
52 5CX6 CDP 3.08057
53 5UIV ADP 3.0837
54 4UA3 COA 3.09278
55 3A06 FOM 3.19149
56 4RI1 ACO 3.22581
57 1TZD ADP 3.27273
58 1S7N COA 3.2967
59 1MID LAP 3.2967
60 4KFU ACP 3.30189
61 3B9Q MLI 3.31126
62 2ZW5 COA 3.32226
63 2OFW ADX 3.36538
64 5NM7 GLY 3.38346
65 2ZR9 DTP 3.4384
66 1V0C KNC 3.46535
67 1V0C ACO 3.46535
68 5HH0 COA 3.5
69 3COB ADP 3.52304
70 2Q4V ACO 3.52941
71 4LHD GLY 3.5545
72 1DAR GDP 3.5545
73 3R9C ECL 3.58852
74 3TO7 COA 3.62319
75 3B5J 12D 3.7037
76 5KUT GDP 3.7037
77 1W2D ADP 3.77358
78 5O74 GDP 3.88889
79 1G6H ADP 3.89105
80 2YNC YNC 3.90625
81 2YNE YNE 3.90625
82 2YNE NHW 3.90625
83 1RRC ADP 3.98671
84 3UIE ANP 4
85 4ZNL BEF ADP 4.0146
86 3HQP FDP 4.02844
87 4U00 ADP 4.09836
88 6EDV COA 4.12371
89 4WZ6 ATP 4.13793
90 4JGP PYR 4.14747
91 1JI0 ATP 4.16667
92 5E5U MLI 4.16667
93 2W47 UNF 4.16667
94 4AVB ACO 4.2042
95 5L3W GDP 4.24837
96 1D2E GDP 4.28212
97 1PUA COA 4.29448
98 1QSR ACO 4.32099
99 1Q2D COA 4.32099
100 1QSN COA 4.32099
101 4C2X NHW 4.39024
102 3IIJ ADP 4.44444
103 3RC3 ANP 4.50237
104 1U0J ADP 4.50237
105 1TD2 PXL 4.52962
106 4R57 ACO 4.54545
107 1I4D GDP 4.6875
108 4WGF HX2 4.87805
109 1B0U ATP 4.96183
110 3P2H NOO 4.97512
111 5TSH ADP 4.9763
112 5YV5 ADP 4.9763
113 3D2M COA 4.9763
114 5TSH ANP 4.9763
115 5GK9 ACO 5.07246
116 1GHE ACO 5.08475
117 3W6G FLC 5.09259
118 4BQS ADP 5.11364
119 2WHX ADP 5.21327
120 2IYL GDP 5.21327
121 4R43 GDP 5.21327
122 4QM7 GTP 5.26316
123 4QAG F95 5.26316
124 3WR7 COA 5.29412
125 2W58 ADP 5.44554
126 4AG9 COA 5.45455
127 4AG9 16G 5.45455
128 1DS6 GDP 5.55556
129 4QC6 30N 5.58659
130 1YZG GDP 5.58659
131 5YW5 ADE 5.58659
132 1IYK MYA 5.61225
133 1BOB ACO 5.625
134 2J0V GDP 5.66038
135 4PSW COA 5.67823
136 6G96 ACO 5.68182
137 1VG9 GDP 5.6872
138 4R2I ANP 5.71429
139 2B99 RDL 5.76923
140 4U9W COA 5.7971
141 3A1S GDP 5.81395
142 5M04 GDP 5.83333
143 2X7I CIT 5.84416
144 3Q85 GNP 5.91716
145 3T5G GDP 5.92105
146 2KIN ADP 6
147 5BSZ THM 6
148 5FVJ ACO 6.0241
149 3TE4 ACO 6.04651
150 1F6B GDP 6.06061
151 3CM2 X23 6.15385
152 4KOT CE3 6.17284
153 2WMC MGP 6.17978
154 4CRZ ACO 6.29371
155 2FT0 ACO 6.38298
156 2B4D COA 6.43275
157 2B4B COA 6.43275
158 6BA2 7KM 6.44068
159 1ONI BEZ 6.52174
160 4LC1 GDP 6.52819
161 3MGB GHP 3MY 3FG GHP GHP OMY 3FG 6.58307
162 3BOS CDP 6.61157
163 2WSA MYA 6.63507
164 2WSA 646 6.63507
165 1VEM GLC GLC 6.63507
166 3H4S ADP 6.66667
167 1SVI GDP 6.66667
168 1KUV CA5 6.76329
169 43CA NPO 6.83761
170 3F8K COA 6.875
171 1G16 GDP 7.05882
172 6D5L FW7 7.18563
173 6D5M FW4 7.18563
174 6D5H FV7 7.18563
175 1TIQ COA 7.22222
176 3ZJ0 ACO 7.28155
177 1OXV ANP 7.36544
178 2OZ5 7XY 7.43243
179 4K30 NLG 7.5
180 3NHB ADP 7.51634
181 5LKT BCO 7.58294
182 5LX9 OLB 7.74648
183 1N71 COA 7.77778
184 4DID GDP 7.89474
185 3KC1 2T6 8.01187
186 5YGE ACO 8.04598
187 5YGE GLU 8.04598
188 1CJW COT 8.43373
189 4R98 GNH 8.48709
190 2W41 ADP 8.53081
191 2WPW ACO 8.55457
192 2WPX ACO 8.55457
193 1LVG ADP 9.09091
194 1JJ7 ADP 9.23077
195 4IHQ ADP 9.35672
196 5W8E SXZ 9.50226
197 5W8E ADE 9.50226
198 1W0J ADP 9.55882
199 2V7Q ADP 9.55882
200 2V7Q ATP 9.55882
201 2CK3 ANP 9.55882
202 2WJG GDP 9.57447
203 3A4M ADP 9.61539
204 2D2F ADP 10
205 1Z0A GDP 10.3448
206 4XPL ACO 10.4294
207 1XX6 ADP 10.4712
208 1BO4 COA 10.7143
209 4KVX ACO 10.8974
210 1M7G AV2 10.9005
211 4CVN ADP 10.9948
212 5BXQ GDP 11.0236
213 4NSQ COA 11.0526
214 1CM0 COA 11.9048
215 3ZIA ATP 12.3188
216 4MTI 2DX 13.0435
217 5H86 BCO 13.0952
218 1QSM ACO 13.1579
219 4R3L COA 13.2948
220 3K9U ACO 13.8365
221 1P0H ACO 13.8365
222 1P0H COA 13.8365
223 5JPH COA 13.8889
224 2JDC CAO 14.3836
225 4YMU ATP 14.5455
226 3GJ5 GDP 14.7059
227 2JEV NHQ 16.6667
228 2VBQ BSJ 16.9697
229 5LS7 ACO 17.0732
230 3UW4 MAA CHG PRO 0DQ 17.3913
231 1UGX GAL MGC 18.0451
232 1GXU 2HP 18.6813
233 2HCJ GDP 18.9189
234 5KF9 ACO 19.5122
235 5KF9 NAG 19.5122
236 5KF9 COA 19.5122
237 1I1D COA 19.8758
238 1I1D 16G 19.8758
239 1WLJ U5P 20.1058
240 3LN9 FLC 20.1439
241 3PQC GDP 23.0769
242 2CNT COA 23.75
243 1M4I COA 23.7569
244 1M4I KAN 23.7569
245 1M4I PAP 23.7569
246 1Q2C COA 36.8421
Pocket No.: 3; Query (leader) PDB : 5TVJ; Ligand: 7LF; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 5tvj.bio1) has 41 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 5TVJ; Ligand: 7LF; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 5tvj.bio1) has 41 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 5TVJ; Ligand: 7LF; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 5tvj.bio1) has 41 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 5TVJ; Ligand: 7LF; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 5tvj.bio1) has 41 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 5TVJ; Ligand: COA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 5tvj.bio1) has 42 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 5TVJ; Ligand: COA; Similar sites found with APoc: 277
This union binding pocket(no: 8) in the query (biounit: 5tvj.bio1) has 42 residues
No: Leader PDB Ligand Sequence Similarity
1 5U0L 8YP 1.18483
2 2J5V PCA 1.3624
3 2Y65 ADP 1.36986
4 2F2U M77 1.4218
5 1V8K ANP 1.46341
6 1BG2 ADP 1.53846
7 1MR3 G3D 1.65746
8 1MKY GDP 1.65877
9 4UWJ MYA 1.7199
10 4UWJ 7L5 1.7199
11 1F9V ADP 1.72911
12 3DC4 ADP 1.74419
13 5H4S RAM 1.76056
14 5MU6 KFK 1.79028
15 5MU6 MYA 1.79028
16 2AWN ADP 1.83727
17 3BIY 01K 1.84211
18 2ZPA ACO 1.89573
19 5FJJ MAN 1.89573
20 2PYW SR1 1.90476
21 4QRH 0O2 1.90476
22 4NON GDP 1.92308
23 4FRZ ADP 2.07254
24 5U32 GDP 2.11864
25 5ZXD ATP 2.1327
26 5ZBR ANP 2.13333
27 3VOZ 04A 2.22222
28 2RCN GDP 2.23464
29 3GJ3 GDP 2.26244
30 3GJ4 GDP 2.26244
31 3GJ7 GDP 2.26244
32 3GJ0 GDP 2.26244
33 1T5C ADP 2.29226
34 2XOC ADE 2.29885
35 3CH5 GDP 2.31481
36 1YQT ADP 2.36967
37 2NCD ADP 2.38095
38 3W5J GDP 2.45098
39 1D8T GDP 2.54453
40 2VVG ADP 2.57143
41 1IID NHM 2.60664
42 2XT3 ADP 2.61628
43 3EC1 GDP 2.71003
44 1XP8 AGS 2.73224
45 2OG2 MLI 2.78552
46 4AG5 ADP 2.80612
47 1GOJ ADP 2.8169
48 2DPY ADP 2.8436
49 3SZB I1E 2.8436
50 1XMV ADP 2.8436
51 2XAU ADP 2.8436
52 5CK5 GDP 2.8481
53 2HT6 GDP 2.87356
54 5HGZ ACO 2.88066
55 5GVR LMR 2.99145
56 4H6U ACO 3
57 4B5P ACO 3
58 3E70 GDP 3.04878
59 2GKS ADP 3.08057
60 4UCI ADN 3.08057
61 5CX6 CDP 3.08057
62 5UIV ADP 3.0837
63 4UA3 COA 3.09278
64 3A06 FOM 3.19149
65 4RI1 ACO 3.22581
66 1TZD ADP 3.27273
67 1S7N COA 3.2967
68 1MID LAP 3.2967
69 4KFU ACP 3.30189
70 3B9Q MLI 3.31126
71 6H45 QEI 3.31633
72 2ZW5 COA 3.32226
73 2OFW ADX 3.36538
74 5NM7 GLY 3.38346
75 1YRB GDP 3.43511
76 2ZR9 DTP 3.4384
77 1V0C ACO 3.46535
78 1V0C KNC 3.46535
79 5HH0 COA 3.5
80 3COB ADP 3.52304
81 2Q4V ACO 3.52941
82 4LHD GLY 3.5545
83 1DAR GDP 3.5545
84 3TO7 COA 3.62319
85 3B5J 12D 3.7037
86 5KUT GDP 3.7037
87 1W2D ADP 3.77358
88 5O74 GDP 3.88889
89 1G6H ADP 3.89105
90 2YNC YNC 3.90625
91 2YNE NHW 3.90625
92 2YNE YNE 3.90625
93 1RRC ADP 3.98671
94 3UIE ANP 4
95 4ZNL BEF ADP 4.0146
96 3HQP FDP 4.02844
97 4U00 ADP 4.09836
98 6EDV COA 4.12371
99 4WZ6 ATP 4.13793
100 4JGP PYR 4.14747
101 1JI0 ATP 4.16667
102 5E5U MLI 4.16667
103 2W47 UNF 4.16667
104 4AVB ACO 4.2042
105 5L3W GDP 4.24837
106 1D2E GDP 4.28212
107 1PUA COA 4.29448
108 1QSR ACO 4.32099
109 1Q2D COA 4.32099
110 1QSN COA 4.32099
111 1VG1 GDP 4.32432
112 4C2X NHW 4.39024
113 3IIJ ADP 4.44444
114 3RC3 ANP 4.50237
115 1U0J ADP 4.50237
116 1TD2 PXL 4.52962
117 4R57 ACO 4.54545
118 1I4D GDP 4.6875
119 4WGF HX2 4.87805
120 1B0U ATP 4.96183
121 3P2H NOO 4.97512
122 5TSH ADP 4.9763
123 3D2M COA 4.9763
124 5YV5 ADP 4.9763
125 4DCT GDP 4.9763
126 5TSH ANP 4.9763
127 5GK9 ACO 5.07246
128 1GHE ACO 5.08475
129 3W6G FLC 5.09259
130 4BQS ADP 5.11364
131 2WHX ADP 5.21327
132 2IYL GDP 5.21327
133 1SKQ GDP 5.21327
134 4R43 GDP 5.21327
135 4QAG F95 5.26316
136 4QM7 GTP 5.26316
137 5KSP GDP 5.26316
138 3WR7 COA 5.29412
139 3P4X ADP 5.32688
140 3MD0 GDP 5.35211
141 2W58 ADP 5.44554
142 4AG9 COA 5.45455
143 4AG9 16G 5.45455
144 1DS6 GDP 5.55556
145 4QC6 30N 5.58659
146 1YZG GDP 5.58659
147 5YW5 ADE 5.58659
148 1IYK MYA 5.61225
149 1BOB ACO 5.625
150 2J0V GDP 5.66038
151 4PSW COA 5.67823
152 6G96 ACO 5.68182
153 5FG3 GDP 5.6872
154 1VG9 GDP 5.6872
155 3IUY AMP 5.70175
156 4R2I ANP 5.71429
157 2B99 RDL 5.76923
158 4U9W COA 5.7971
159 3A1S GDP 5.81395
160 5M04 GDP 5.83333
161 2X7I CIT 5.84416
162 3Q85 GNP 5.91716
163 3T5G GDP 5.92105
164 2KIN ADP 6
165 5BSZ THM 6
166 5FVJ ACO 6.0241
167 3TE4 ACO 6.04651
168 1F6B GDP 6.06061
169 1RE0 GDP 6.09756
170 3CM2 X23 6.15385
171 4KOT CE3 6.17284
172 2WMC MGP 6.17978
173 4CRZ ACO 6.29371
174 2FT0 ACO 6.38298
175 2B4D COA 6.43275
176 2B4B COA 6.43275
177 6BA2 7KM 6.44068
178 1ONI BEZ 6.52174
179 2QN6 GDP 6.52174
180 4LC1 GDP 6.52819
181 5YT0 GDP 6.59341
182 3BOS CDP 6.61157
183 2WSA 646 6.63507
184 2WSA MYA 6.63507
185 1VEM GLC GLC 6.63507
186 3H4S ADP 6.66667
187 1SVI GDP 6.66667
188 1KUV CA5 6.76329
189 2CJW GDP 6.77083
190 1JJV ATP 6.79612
191 43CA NPO 6.83761
192 3F8K COA 6.875
193 1G16 GDP 7.05882
194 6D5L FW7 7.18563
195 6D5M FW4 7.18563
196 6D5H FV7 7.18563
197 1TIQ COA 7.22222
198 1G6O ADP 7.27273
199 3ZJ0 ACO 7.28155
200 1OXV ANP 7.36544
201 2OZ5 7XY 7.43243
202 4K30 NLG 7.5
203 3NHB ADP 7.51634
204 5LKT BCO 7.58294
205 5LX9 OLB 7.74648
206 1N71 COA 7.77778
207 4DID GDP 7.89474
208 3KC1 2T6 8.01187
209 5YGE ACO 8.04598
210 5YGE GLU 8.04598
211 1CJW COT 8.43373
212 4R98 GNH 8.48709
213 2IS6 ADP 8.53081
214 2W41 ADP 8.53081
215 4B47 GDP 8.53994
216 2WPW ACO 8.55457
217 2WPX ACO 8.55457
218 1LVG ADP 9.09091
219 1JJ7 ADP 9.23077
220 4IHQ ADP 9.35672
221 5W8E SXZ 9.50226
222 5W8E ADE 9.50226
223 2V7Q ADP 9.55882
224 1W0J ADP 9.55882
225 2V7Q ATP 9.55882
226 2CK3 ANP 9.55882
227 2WJG GDP 9.57447
228 3A4M ADP 9.61539
229 1ZHS NAG NAG BMA MAN MAN 9.73451
230 2D2F ADP 10
231 1Z0A GDP 10.3448
232 4XPL ACO 10.4294
233 1XX6 ADP 10.4712
234 1BO4 COA 10.7143
235 4KVX ACO 10.8974
236 1M7G AV2 10.9005
237 4CVN ADP 10.9948
238 5BXQ GDP 11.0236
239 4NSQ COA 11.0526
240 1ZJ6 G3D 11.2299
241 1CM0 COA 11.9048
242 2CDN ADP 11.9403
243 3ZIA ADP 12.3188
244 3ZIA ATP 12.3188
245 4MTI 2DX 13.0435
246 5H86 BCO 13.0952
247 1QSM ACO 13.1579
248 4R3L COA 13.2948
249 3K9U ACO 13.8365
250 1P0H ACO 13.8365
251 1P0H COA 13.8365
252 5JPH COA 13.8889
253 2JDC CAO 14.3836
254 4YMU ATP 14.5455
255 3GJ5 GDP 14.7059
256 2JEV NHQ 16.6667
257 2VBQ BSJ 16.9697
258 5LS7 ACO 17.0732
259 3UW4 MAA CHG PRO 0DQ 17.3913
260 3TK1 GDP 17.5758
261 1UGX GAL MGC 18.0451
262 1FZQ GDP 18.232
263 1GXU 2HP 18.6813
264 2HCJ GDP 18.9189
265 5KF9 ACO 19.5122
266 5KF9 NAG 19.5122
267 5KF9 COA 19.5122
268 1I1D COA 19.8758
269 1I1D 16G 19.8758
270 1WLJ U5P 20.1058
271 3LN9 FLC 20.1439
272 3PQC GDP 23.0769
273 2CNT COA 23.75
274 1M4I PAP 23.7569
275 1M4I KAN 23.7569
276 1M4I COA 23.7569
277 1Q2C COA 36.8421
Pocket No.: 9; Query (leader) PDB : 5TVJ; Ligand: COA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 5tvj.bio1) has 42 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 10; Query (leader) PDB : 5TVJ; Ligand: COA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 10) in the query (biounit: 5tvj.bio1) has 42 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 11; Query (leader) PDB : 5TVJ; Ligand: COA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 11) in the query (biounit: 5tvj.bio1) has 42 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 12; Query (leader) PDB : 5TVJ; Ligand: COA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 12) in the query (biounit: 5tvj.bio1) has 42 residues
No: Leader PDB Ligand Sequence Similarity
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