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Receptor
PDB id Resolution Class Description Source Keywords
3R1N 2.09 Å EC: 2.7.11.1 MK3 KINASE BOUND TO COMPOUND 5B HOMO SAPIENS KINASE DOMAIN WITH BOUND INHIBITOR KINASE DOMAIN PHOSPHOTRANSFERASE TRANSFERASE-TRANSFERASE INHIBITOR COMPL
Ref.: STRUCTURE-BASED LEAD IDENTIFICATION OF ATP-COMPETIT INHIBITORS. BIOORG.MED.CHEM.LETT. V. 21 3818 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
05B A:1;
Valid;
none;
submit data
403.434 C22 H21 N5 O3 c1cc2...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3FHR 1.9 Å EC: 2.7.11.1 HIGH RESOLUTION CRYSTAL STRUCTURE OF MITOGEN-ACTIVATED PROTE ACTIVATED PROTEIN KINASE 3 (MK3)-INHIBITOR COMPLEX HOMO SAPIENS KINASE-INHIBITOR COMPLEX ATP-BINDING KINASE NUCLEOTIDE-BINUCLEUS PHOSPHOPROTEIN SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: HIGH-RESOLUTION CRYSTAL STRUCTURE OF HUMAN MAPKAP K IN COMPLEX WITH A HIGH AFFINITY LIGAND PROTEIN SCI. V. 19 168 2010
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 3FHR - P4O C21 H16 N4 O c1ccc2c(c1....
2 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
3 3SHE - I85 C24 H22 F3 N5 O2 c1cc(cc(c1....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 3FHR - P4O C21 H16 N4 O c1ccc2c(c1....
2 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
3 3SHE - I85 C24 H22 F3 N5 O2 c1cc(cc(c1....
4 3M2W ic50 < 0.003 uM L8I C23 H21 F N4 O CN1CC2(C1)....
50% Homology Family (199)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 5OPU ic50 = 0.1237 uM A3K C15 H12 N4 Cc1cccc(c1....
3 5OP4 ic50 = 0.4476 uM A0T C19 H21 F4 N5 O3 CCNc1c(cnc....
4 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
5 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
6 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
7 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
8 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
9 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
10 5OQ6 ic50 = 0.0828 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
11 6FCF ic50 = 0.006 uM D58 C20 H22 N4 O S C[C@@H]1[C....
12 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
13 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
14 5OPB ic50 = 0.0577 uM A1N C21 H25 N5 O2 C[C@@H]1CN....
15 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
16 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
17 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
18 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
19 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
20 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
21 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
22 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
23 5OPV ic50 = 0.1203 uM A3H C19 H16 N6 Cc1cccc(c1....
24 5OOT ic50 = 0.0681 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
25 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
26 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
27 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
28 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
29 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
30 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
31 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
32 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
33 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
34 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
35 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
36 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
37 5JQ5 Kd = 2341 nM I74 C22 H30 N6 O CC(C)c1cnn....
38 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
39 1V1K Ki = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)C[C@H....
40 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
41 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
42 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
43 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
44 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
45 2UZO ic50 = 18 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
46 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
47 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
48 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
49 5JQ8 - I73 C22 H30 N6 O CC(C)c1cnn....
50 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
51 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
52 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
53 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
54 1PXP Ki ~ 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
55 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]/N=C/1N....
56 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
57 5K4J - 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
58 3PJ8 - 404 C19 H26 N6 O CC[C@H](CO....
59 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
60 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
61 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
62 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
63 5IEX - 6AF C17 H21 Br N4 O3 S C[C@H]([C@....
64 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
65 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
66 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
67 5LI9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
68 3A8W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
69 2F2U - M77 C14 H17 N3 O2 S c1cc2cnccc....
70 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
71 5OYF - B4Q C25 H27 N3 CCc1ccccc1....
72 5H8G ic50 < 0.003 uM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
73 5OS7 - A8Q C16 H19 Cl N CC(C)c1ccc....
74 5OTZ Kd = 6.5 uM AUT C15 H15 Cl2 N CCc1ccccc1....
75 5OUM - AVK C18 H18 Cl N3 c1ccc(cc1)....
76 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
77 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
78 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
79 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
80 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
81 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
82 1SZM ic50 = 6.35 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
83 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
84 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
85 1MQ4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
86 5EW9 Ki < 0.01 nM 5VC C22 H21 Cl F N3 O3 S c1cc(nc(c1....
87 5ORY ic50 = 407 uM AY4 C9 H6 F2 N2 O c1c[nH]nc1....
88 4CEG - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
89 5ORV Kd = 1297 uM A65 C6 H9 N O S3 CSc1c(c(sn....
90 5OS6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3DJ6 - AK6 C25 H24 N4 O3 S COc1ccc(cc....
92 5OSF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
93 2WQE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
94 6CPF - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
95 3FDN ic50 = 0.033 uM MMH C21 H22 N6 O3 Cc1c(c([nH....
96 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
97 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
98 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
99 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
100 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
101 1P4F - DRG C12 H11 N3 c1ccc-2c(c....
102 4TXC Kd = 0.24 uM 38G C24 H27 N5 O3 CN(C)CCN[C....
103 2YAK ic50 = 2 nM OSV C27 H31 F N4 O3 Ru S4 CC(C)Oc1cc....
104 5AUY ic50 = 1.6 uM MRI C15 H10 O7 c1cc(c(cc1....
105 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
106 5LVO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
107 4XX9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
108 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
109 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 C[C@@H]1C[....
110 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
111 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
112 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
113 5ACK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
114 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
115 5LVM - ADE C5 H5 N5 c1[nH]c2c(....
116 5MRD ic50 = 36.4 uM S26 C18 H13 Cl N2 O4 S2 CCOC(=O)C1....
117 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
118 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 C[N@@]1CCC....
119 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
120 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
121 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
122 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
123 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
124 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
125 3QD3 ic50 = 0.00000001 M 3Q5 C22 H30 N8 O2 C[C@H]1CC[....
126 1OKY ic50 = 6.5 nM STU C28 H26 N4 O3 C[C@@]12[C....
127 3IOP ic50 = 17 nM 8I1 C28 H27 N5 O3 COc1cc2c3c....
128 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
129 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
130 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
131 3QCQ ic50 = 0.00000001 M 3Q0 C13 H15 N7 CCNc1cc(nc....
132 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
133 2R5T - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
134 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
135 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
136 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
137 2UW9 - GVP C20 H20 Cl N3 c1cc(ccc1c....
138 2JDR ic50 = 0.5 nM L20 C24 H23 N5 O Cc1c2cc(cc....
139 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
140 4QMX ic50 = 11 uM H8H C27 H32 Cl N5 O5 CN1CCN(CC1....
141 4QMT ic50 = 0.01 uM H1N C29 H32 N4 O3 S CCS(=O)(=O....
142 4QMM ic50 = 0.46 uM 35R C19 H23 N7 O2 c1cc2c(cc1....
143 4QMU ic50 = 1.3 uM SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
144 4W8E - 3JB C20 H17 N7 O2 Cc1nc(no1)....
145 4QMZ ic50 = 0.21 uM B49 C22 H27 F N4 O2 CCN(CC)CCN....
146 3UBD Kd = 2.9 uM SL0 C25 H24 O12 CC1C(C(C(C....
147 4GUE Kd = 5.8 uM QCT C21 H20 O11 C[C@H]1[C@....
148 3G51 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
149 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
150 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
151 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
152 1U5R - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
153 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 [H]/N=C(N)....
154 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
155 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 [H]/N=C(N/....
156 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
157 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O C/C(=NNC1=....
158 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
159 4BDB ic50 = 85.6 uM ODO C8 H9 N O3 C/C(=NO)/c....
160 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCC/C(=NNC....
161 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]/N=C(N)....
162 6CCY ic50 = 0.003 uM EX4 C29 H33 F4 N7 O C[C@@H]1CC....
163 3QKK - SMH C28 H38 N2 O7 S CCOCCN(C[C....
164 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 C[C@@H]1C[....
165 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
166 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1[....
167 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
168 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
169 3QKL - SMR C29 H40 N4 O5 S CCOCC[N@@]....
170 5DH3 ic50 = 38.1 nM 5BS C17 H16 N6 O3 S2 CN1c2ccsc2....
171 5OTF - AQ5 C20 H24 N6 c1cnc2c(c1....
172 3TKU ic50 = 1.92 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
173 3V8S ic50 = 0.65 uM 0HD C16 H16 N4 O c1ccc(cc1)....
174 4OTH ic50 = 9 nM DRN C25 H23 N5 O2 S [H]/N=C(/N....
175 5OOI - 9YE C23 H25 N O3 CC(C)n1c2c....
176 6CQF ic50 = 0.0045 uM F97 C21 H26 F2 N8 CC(C)n1c2c....
177 3A62 - STU C28 H26 N4 O3 C[C@@]12[C....
178 3WF9 ic50 = 567 nM FS7 C24 H25 N3 O5 S C[C@H]1CCc....
179 3WF8 ic50 = 232 nM F76 C23 H23 N3 O5 S c1ccc2c(c1....
180 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
181 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
182 3WF5 ic50 = 81 nM FZ8 C17 H17 N7 c1ccc2c(c1....
183 3FY0 ic50 = 1090 nM DW1 C23 H13 N3 O4 Ru C1=CC(C=C1....
184 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
185 4OBQ ic50 = 0.065 uM 2QT C20 H20 F N5 O c1cc2c(cc1....
186 4U43 Kd = 48 uM 3D8 C11 H9 N5 c1cc(cnc1)....
187 4OBP ic50 = 0.017 uM 2QU C12 H8 F N5 c1cc(nc2c1....
188 6C0T ic50 = 43 nM EE4 C30 H30 F N5 O5 CCCOc1ccc(....
189 6BXI - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
190 3DV3 - MEK C18 H18 F3 I N2 O5 c1cc(c(cc1....
191 3EQD - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
192 5F9E ic50 = 0.46 nM 5VS C23 H21 N5 O2 CC1(NC(=O)....
193 1XJD Ki = 0.33 nM STU C28 H26 N4 O3 C[C@@]12[C....
194 5DBX - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
195 3TXO ic50 = 9 nM 07U C17 H19 N5 CC(C)(CNc1....
196 4USF - 6UI C19 H15 N3 O COc1ccc2cc....
197 2J51 - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
198 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
199 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 05B; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 05B 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3FHR; Ligand: P4O; Similar sites found with APoc: 405
This union binding pocket(no: 1) in the query (biounit: 3fhr.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 2EFX NFA 1.19048
2 1GSA ADP 1.26582
3 2VPQ ANP 1.4881
4 2P4S DIH 1.4881
5 4ZS4 ATP 1.62866
6 4XMF HSM 1.63043
7 1JG3 ADN 1.70213
8 3VPC ADP 1.77305
9 2VQD AP2 1.78571
10 5O9W AKG 1.78571
11 3PDT ADP 1.81818
12 3VOT ADP 1.88235
13 3PN1 IVH 1.88679
14 3TDV GDP 1.96078
15 4LCN GNG 2.03046
16 1SQL GUN 2.05479
17 3RG9 WRA 2.08333
18 3RG9 NDP 2.08333
19 4PZ6 GMP 2.08333
20 3K5I ADP 2.08333
21 3VPD ANP 2.13523
22 4R78 AMP 2.26537
23 3UDZ ADP 2.38095
24 2PYW ADP 2.38095
25 4B0T ADP 2.38095
26 3B8Y ADA ADA ADA ADA 2.38095
27 1S68 AMP 2.40964
28 4Z4P SAH 2.40964
29 3ZJX BOG 2.42215
30 4QBK 3NZ 2.57732
31 5C1P ADP 2.61438
32 1M0W ANP 2.67857
33 5AE9 OKO 2.67857
34 3KAL ADP 2.67857
35 5VZ0 ADP 2.67857
36 5GLN XYP XYP XYP 2.67857
37 2Z48 NGA 2.67857
38 6EZ6 C5Z 2.67857
39 2HGS ADP 2.67857
40 5OLK DTP 2.67857
41 4M26 AKG 2.74725
42 2AQX ATP 2.76817
43 5IDB BMA 2.8169
44 5IDB MAN 2.8169
45 6FTB M0E 2.85714
46 6BOX SAH 2.9703
47 3X01 AMP 2.97619
48 5IM3 DTP 2.97619
49 5WS9 OXL 2.97619
50 4X3R 686 2.97619
51 1C3X 8IG 3.00752
52 4B1L FRU 3.0303
53 2XOC ADP 3.06513
54 1ZTH ADP 3.10078
55 1ZP9 ATP 3.10078
56 1OS7 AKG 3.18021
57 4O4F ATP 3.22581
58 4O4F IHP 3.22581
59 1UMZ BGC BGC XYS BGC XYS GAL 3.23741
60 2IF8 ADP 3.27381
61 3TY5 ATP 3.27381
62 2BMB PMM 3.27381
63 5T96 79J 3.27381
64 4EIL NDP 3.27381
65 3WO0 ADP 3.27381
66 3WO0 ALA 3.27381
67 3TY5 ADP 3.27381
68 5GZ9 ANP 3.27869
69 5GZ9 MAN 3.27869
70 3TM0 ANP 3.42205
71 3TM0 B31 3.42205
72 4M7V NAP 3.42857
73 6DW2 HD4 3.52941
74 5YK1 ANP 3.57143
75 2V58 LZJ 3.57143
76 3DNT ATP 3.57143
77 2ZYI STE 3.57143
78 2GJ5 VD3 3.7037
79 2VT3 ATP 3.72093
80 2ZL7 FUC GAL NGA 3.72881
81 2GQR ADP 3.79747
82 4EN4 GT0 3.84615
83 4EN4 ATP 3.84615
84 4EN4 GT1 3.84615
85 2QK4 ATP 3.86905
86 3VSV XYS 3.86905
87 5FJN BE2 3.86905
88 5FJN FAD 3.86905
89 4ARE FLC 3.86905
90 2R7K AMZ 3.86905
91 2R7K ACP 3.86905
92 4OUJ LBT 3.90879
93 3FSY SCA 3.91566
94 4FE2 ADP 3.92157
95 2WCU FUC 4.02685
96 1QAW TRP 4.05405
97 3FW3 GLC 4.13534
98 3BP1 GUN 4.13793
99 5OES ADP 4.16667
100 4OCJ NDG 4.16667
101 3W0O ADP 4.16667
102 3W0O HY0 4.16667
103 1OKE BOG 4.16667
104 1AOE GW3 4.16667
105 1AOE NDP 4.16667
106 4OCV ANP 4.16667
107 3ETH ATP 4.16667
108 4CS9 AMP 4.2328
109 4NZN ANP 4.24242
110 4NZN 2OU 4.24242
111 5EQY 5RA 4.46429
112 3F70 MLZ 4.46429
113 2GQS ADP 4.64135
114 1FUT 2GP 4.71698
115 5MW8 ATP 4.7619
116 3NRR NAP 4.7619
117 4LO2 GAL BGC 4.7619
118 4UWH JXM 4.7619
119 1P6O HPY 4.96894
120 3TII ANP 5.05952
121 5TT6 ATP 5.05952
122 2NVK FAD 5.05952
123 1A5V Y3 5.06329
124 1IOW PHY 5.22876
125 1IOW ADP 5.22876
126 4GYI ADP 5.35714
127 6A5K SAM 5.35714
128 1PK8 ATP 5.35714
129 4U98 ACP 5.35714
130 3KJS NAP 5.35714
131 4IA6 EIC 5.35714
132 5HWV MBN 5.38462
133 1AUX AGS 5.46624
134 1I7L ATP 5.50162
135 1OBD ATP 5.55556
136 2W9S NDP 5.59006
137 5A96 GTP 5.62249
138 6FL8 ADP 5.65476
139 6FL8 TIY 5.65476
140 5DZT AMP 5.65476
141 4PU5 ANP 5.65476
142 5K2M ADP 5.66038
143 4NFE BEN 5.90717
144 2BKK ADP 5.91716
145 2IO8 ADP 5.95238
146 4DP3 NDP 6.25
147 5IGI ZIT 6.31229
148 5IGI GMP 6.31229
149 1G1T SIA GAL MAG FUC 6.36943
150 1J3I NDP 6.40244
151 1XVB BHL 6.47059
152 1ONI BEZ 6.52174
153 1TZD ADP 6.54545
154 5FI4 5XV 6.54762
155 5COU ATP 6.54762
156 1IA9 ANP 6.78571
157 1BHX ASP PHE GLU GLU ILE 6.80272
158 2CB8 MYA 6.89655
159 5HP8 PYR 7.25806
160 3IA4 NDP 7.40741
161 6C1S EFV 7.44048
162 5Y4R C2E 7.58621
163 4O1P ANP 7.7381
164 3I0O ADP 7.7381
165 2UYN 2KT 7.75194
166 2UYP PPI 7.75194
167 2GOO NDG 7.89474
168 2GK6 ADP 8.03571
169 3FXU TSU 8.19672
170 4DFU QUE 8.38509
171 5C4L SIS 8.41121
172 5C4L 4XR 8.41121
173 2OQ5 BEN 8.62069
174 4LH7 1X8 8.66873
175 4B5W PYR 8.98438
176 3WVR AMP 9.22619
177 4XYM A12 9.52381
178 6CGD GNP 9.83607
179 6CGD AKN 9.83607
180 1CBK ROI 10
181 3BEO UDP 10.119
182 5ZCT ANP 10.4575
183 5C8W PCG 10.4895
184 1W2D ADP 10.566
185 1W2D 4IP 10.566
186 5I35 ANP 10.7143
187 2PUL ACP 11.0119
188 5L2R MLA 11.0119
189 2BS5 BGC GAL FUC 11.1111
190 4IX4 ADP 11.3095
191 4XZ3 ACP 11.3095
192 5MY8 RXZ 11.9048
193 2XRH NIO 12
194 3DGY 2GP 12.3711
195 1RGE 2GP 12.5
196 2ET1 GLV 12.9353
197 4XH0 ADP 13.0952
198 1VJY 460 13.2013
199 1RDS GPC 13.3333
200 2QLU ADE 13.3758
201 4AZW ATP 13.3929
202 5CKW ANP 14.2857
203 3VPB ADP 14.2857
204 1OYJ GSH 14.2857
205 3UIM ANP 14.7239
206 5LPZ ADP 15.6627
207 1JGU HBC 15.6682
208 5JKG 6LF 15.7556
209 4OAV ACP 16.369
210 5QIN J2V 16.4557
211 6GWR FEW 16.5079
212 4GJ3 0XP 16.5563
213 2X2M X2M 16.5605
214 4E1Z 0MX 16.8385
215 2PVF ACP 17.0659
216 5LPB ADP 17.5676
217 5WNL STU 18.1548
218 4CYI ATP 18.1548
219 3RI1 3RH 18.2109
220 3C1X CKK 18.75
221 1R1Q ACE ARG GLU PTR VAL ASN VAL 19
222 5C03 AGS 19.0476
223 3GQI ACP 19.3252
224 3O5N BR0 19.6429
225 5EOB 5QQ 19.7492
226 5HES 032 19.8697
227 4WOV 3SM 20.1893
228 6ES0 BW8 20.1893
229 6A1G 9OL 20.2381
230 3H9R TAK 20.303
231 4KBA 1QM 20.5438
232 5UR1 YY9 20.5788
233 4CLI 5P8 20.7951
234 5KO1 6UY 20.8481
235 5JFS 6K0 21.1039
236 4E93 GUI 21.131
237 5OKT 9XK 21.6561
238 4WW7 AMP 21.8391
239 3VHE 42Q 22.0238
240 4EWH T77 22.1818
241 6GIN IR2 22.2591
242 3PLS ANP 22.4832
243 3VRY B43 22.619
244 4Y93 746 22.9167
245 2H8H H8H 23.2143
246 1Y57 MPZ 23.2143
247 4K33 ACP 23.3846
248 3GNI ATP 23.8095
249 4FF8 14S 23.839
250 4Q5H ANP 24.1379
251 4FL3 ANP 24.4048
252 1U5R ATP 25
253 4CRL C1I 25
254 1U59 STU 25.0871
255 4H3Q ANP 25.1381
256 4H3P ANP 25.2976
257 4YZC STU 25.2976
258 5BVE 4VG 25.2976
259 4NM5 ADP 25.8929
260 2JLD AG1 25.8929
261 6E8I PTR 26.0355
262 3SXS PP2 26.1194
263 4NST ADP 26.1905
264 5EFQ ADP 26.4881
265 3F7Z 34O 26.5714
266 4U0I 0LI 26.6667
267 4Y85 499 26.8072
268 6CMJ F6J 27.1028
269 3G5D 1N1 27.2727
270 5T8O 76Z 27.381
271 3BZ3 YAM 27.5362
272 3HMO STU 27.6786
273 3LXK MI1 27.8287
274 5JGA 6KC 27.9365
275 3ZRM ZRM 28.125
276 2HK5 1BM 28.1481
277 4IDT T28 28.2738
278 4ASE AV9 28.2738
279 5FBN 5WF 28.4133
280 5TA6 79D 28.4916
281 4BTK DTQ 28.5714
282 4BHN BH9 28.7425
283 1CM8 ANP 28.869
284 2OFV 242 28.8809
285 3KMW ATP 29.1513
286 4YMJ 4EJ 29.1667
287 3PTG 932 29.4766
288 4RFM 3P6 29.6992
289 3PVW QRX 29.7619
290 5UKL SIX 29.7619
291 5WO4 B7V 29.8013
292 2CSN CKI 29.9663
293 4UX9 ANP 30.0595
294 4IZY 1J2 30.0595
295 4QTB 38Z 30.0595
296 4AG8 AXI 30.0633
297 3FC2 IBI 30.4478
298 1OPK P16 30.6548
299 3NW7 LGV 30.9446
300 1K3A ACP 31.1037
301 5HCY 60D 31.1178
302 5TO8 7FM 31.2057
303 1IR3 ANP 31.3725
304 3BU5 ATP 31.3725
305 4WHZ 3NL 31.8452
306 1ZY5 ANP 32.0132
307 4TWP AXI 32.1033
308 3EKK GS2 32.2476
309 1BYG STU 32.3741
310 6E2O S0L 32.5424
311 3LXN MI1 33.0189
312 5Y86 HRM 33.0357
313 4AUA 4AU 33.0357
314 6C7Y ADP 33.2168
315 1O9U ADZ 33.3333
316 3GC8 B45 33.3333
317 4AT3 LTI 33.4448
318 2A19 ANP 33.4507
319 3KRL KRL 33.7313
320 4P5Z Q7M 34.5238
321 5USZ SKE 34.6021
322 5NKB 8ZT 34.6405
323 1OUK 084 34.8214
324 4LOO SB4 34.8214
325 6GQM F8H 35.061
326 1JPA ANP 35.2564
327 3ALN ANP 35.474
328 2ZV2 609 35.5705
329 5MJA 7O3 35.7377
330 5LI1 ANP 36.0119
331 5LI9 ACP 36.0119
332 5EH0 5NW 36.0465
333 4DC2 ADE 36.3095
334 4WNK 453 36.3095
335 2XVD AS6 36.4238
336 5AWM ANP 36.6071
337 4OTH DRN 36.6071
338 1V0O INR 37.1528
339 4L9I 8PR 37.5
340 4PNI KQQ 37.5
341 4UXL 5P8 37.8882
342 6C0T EE4 38.0952
343 2Y6O 1N1 38.1443
344 2OO8 RAJ 38.1703
345 2BPM 529 38.1877
346 4QMN DB8 38.3871
347 5DBX ANP 38.3929
348 3LQV ADE 38.4615
349 3SRV S19 38.6282
350 3PP0 03Q 38.6905
351 4CFU 2WC 38.9439
352 2WU6 DKI 38.9881
353 4F4P 0SB 39.1941
354 4BCQ TJF 39.2027
355 4BCM T7Z 39.2027
356 1XJD STU 39.2857
357 4BCN T9N 39.3333
358 3TXO 07U 39.5833
359 6FYV 3NG 39.5833
360 3E8N ATP 39.5894
361 3E8N VRA 39.5894
362 2XMY CDK 39.5973
363 5LMK 6ZK 39.7306
364 5HQ0 LZ9 39.7351
365 6GU6 1QK 39.7351
366 5ZTN CUR 39.881
367 3E7O 35F 39.881
368 6GUE FB8 40.0662
369 3SLS ANP 40.1316
370 6G33 5ID 40.4762
371 5X8I SQZ 40.4762
372 5H2U 1N1 40.824
373 5VC5 96M 40.8304
374 6CZ3 FLJ 40.9091
375 5U6C 7YS 40.9524
376 2B9J ADP 41.0714
377 2B9I ADP 41.0714
378 2B9H ADP 41.0714
379 4WB6 ATP 41.0714
380 2QCS ANP 41.0714
381 3FHI ANP 41.0714
382 4WB7 ATP 41.0714
383 3IDB ANP 41.369
384 1RE8 BD2 41.369
385 2GU8 796 41.369
386 2B9F ADP 41.6667
387 6FYL 3NG 41.6667
388 3TTI KBI 41.6667
389 4CSV STI 41.8182
390 5N87 N66 42.1725
391 4I6H 1C8 42.2078
392 3GC0 AMP 42.5532
393 5EKO N17 42.8571
394 5JLB SAH 42.8571
395 4AU8 Z3R 42.9054
396 1UNH IXM 43.4931
397 3O0G 3O0 43.4931
398 2F57 23D 43.75
399 2F2U M77 44.9405
400 5CEO 50D 45
401 2V7O DRN 45.5357
402 4ONA UW1 46.131
403 2WEL K88 47.7064
404 2VZ6 FEF 47.9233
405 1PHK ATP 48.9933
406 3IGO ANP 50
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