Receptor
PDB id Resolution Class Description Source Keywords
3RDV 1.75 Å NON-ENZYME: OTHER STRUCTURE OF THE SLAIN2C-CLIPCG1 COMPLEX HOMO SAPIENS CYTOSKELETAL PROTEIN CAP GLY PROTEIN COMPLEX STRUCTURAL PR
Ref.: SLAIN2 LINKS MICROTUBULE PLUS END-TRACKING PROTEINS CONTROLS MICROTUBULE GROWTH IN INTERPHASE J.CELL BIOL. V. 193 1083 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ASP SER TRP LYS ASP GLY CYS TYR E:574;
F:574;
G:575;
H:574;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
798.943 n/a SCC(N...
BME C:1;
Invalid;
none;
submit data
78.133 C2 H6 O S C(CS)...
NA A:1;
Invalid;
none;
submit data
22.99 Na [Na+]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3RDV 1.75 Å NON-ENZYME: OTHER STRUCTURE OF THE SLAIN2C-CLIPCG1 COMPLEX HOMO SAPIENS CYTOSKELETAL PROTEIN CAP GLY PROTEIN COMPLEX STRUCTURAL PR
Ref.: SLAIN2 LINKS MICROTUBULE PLUS END-TRACKING PROTEINS CONTROLS MICROTUBULE GROWTH IN INTERPHASE J.CELL BIOL. V. 193 1083 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 3RDV - ASP SER TRP LYS ASP GLY CYS TYR n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 3RDV - ASP SER TRP LYS ASP GLY CYS TYR n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 3RDV - ASP SER TRP LYS ASP GLY CYS TYR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ASP SER TRP LYS ASP GLY CYS TYR; Similar ligands found: 83
No: Ligand ECFP6 Tc MDL keys Tc
1 ASP SER TRP LYS ASP GLY CYS TYR 1 1
2 ASP ASN ARG LEU GLY LEU VAL TYR TRP PHE 0.567797 0.793103
3 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.540541 0.854839
4 ASP GLU ASP LYS TRP ASP ASP PHE 0.52381 0.779661
5 ALA LEU ASP LYS TRP ASP 0.512 0.770492
6 ALA LEU ASP LYS TRP ALA SER 0.51145 0.777778
7 PHE GLN TRP MET GLY TYR GLU LEU TRP 0.509804 0.84375
8 LYS TRP LYS 0.508929 0.758621
9 ILE ASP TRP PHE GLU GLY LYS GLU 0.506944 0.819672
10 MET LEU TRP GLY TYR LEU GLN TYR VAL 0.506849 0.857143
11 ILE ASP TRP PHE ASP GLY LYS ASP 0.503546 0.819672
12 MET LEU ILE TYR SER MET TRP GLY LYS 0.496815 0.835821
13 ILE ASP TRP PHE ASP GLY LYS GLU 0.496552 0.819672
14 GLU LEU ASP LYS TRP ALA GLY 0.496296 0.816667
15 ASP SER LYS ASP VAL LYS GLU TRP TYR VAL ZN 0.486486 0.818182
16 TYR GLU TRP 0.483607 0.807018
17 GLU LEU GLU LYS TRP ALA SER 0.481481 0.790323
18 ALA TRP LEU PHE GLU ALA 0.481203 0.745763
19 SER SER VAL VAL GLY VAL TRP TYR LEU 0.479167 0.809524
20 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.477273 0.736842
21 GLY LEU MET TRP LEU SER TYR PHE VAL 0.47651 0.830769
22 TYR TRP ALA ALA ALA ALA 0.47619 0.789474
23 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.475 0.771429
24 LYS TRP 0.468468 0.736842
25 SER ARG TYR TRP ALA ILE ARG THR ARG 0.464516 0.732394
26 GLY SER HIS LEU GLU VAL GLN GLY TYR TRP 0.463415 0.818182
27 ALA ALA TRP LEU PHE GLU ALA 0.460432 0.745763
28 GLU ASN ASP LYS TRP ALA SER 0.457143 0.777778
29 GLU LEU ASP LYS TRP ALA SER 0.457143 0.777778
30 SER SER VAL ILE GLY VAL TRP TYR LEU 0.456954 0.796875
31 GLU GLN ASP LYS TRP ALA SER 0.453901 0.761905
32 GLU ALA ASP LYS TRP GLN SER 0.453901 0.761905
33 ACE GLU TRP TRP TRP 0.453782 0.758621
34 MET TYR TRP TYR PRO TYR 0.452055 0.764706
35 GLY GLY LYS LYS LYS TYR LYS LEU 0.448 0.766667
36 VAL CYS TRP GLY GLU LEU MET ASN LEU 0.444444 0.757576
37 GLU LEU ASP LYS TRP ALA ASN 0.443662 0.761905
38 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.443182 0.710526
39 GLU LEU ASP ORN TRP ALA SER 0.440559 0.761905
40 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.44 0.733333
41 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.439189 0.793651
42 SER SER ARG LYS GLU TYR TYR ALA 0.438462 0.723077
43 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.438356 0.793651
44 ACE ASN TRP GLU THR PHE 0.4375 0.774194
45 ARG ARG ARG ARG SER TRP TYR 0.435714 0.710145
46 GLY GLY LYS LYS LYS TYR GLN LEU 0.431818 0.754098
47 ALA LEU ASP LYS TRP GLN ASN 0.431818 0.783333
48 ARG LEU TRP SER 0.431818 0.691176
49 GLU ASN GLN LYS GLU TYR PHE PHE 0.428571 0.721311
50 PCA LYS TRP 0.426357 0.810345
51 LEU LEU GLU LEU ASP LYS TRP ALA NH2 0.421769 0.783333
52 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.42069 0.695652
53 LEU GLU LYS ALA ARG GLY SER THR TYR 0.420382 0.661972
54 LYS ARG TRP ILE ILE LEU GLY LEU ASN LYS 0.419753 0.714286
55 GLU LEU ASP HOX TRP ALA SER 0.418919 0.712121
56 GLU ASP ASN ASP TRP ASN 0.416667 0.672131
57 ASP TRP ASN 0.416667 0.672131
58 ALA SER ASN GLU ASN TRP GLU THR MET 0.414966 0.746269
59 PHE ALA PRO GLY ASN TYR PRO ALA TRP 0.414201 0.823529
60 ALA LEU TRP GLY PHE PHE PRO VAL LEU 0.41358 0.757576
61 LYS TYR LYS 0.412281 0.706897
62 ASN ASP TRP LEU LEU PRO SER TYR 0.412121 0.763889
63 GLN ALA SER GLN GLU VAL LYS ASN TRP 0.411765 0.769231
64 GLY GLY LYS LYS LYS TYR ARG LEU 0.411765 0.686567
65 GLY GLY LYS LYS ARG TYR LYS LEU 0.411765 0.686567
66 GLY GLY ARG LYS LYS TYR LYS LEU 0.411765 0.686567
67 ARG TYR PRO LEU THR PHE GLY TRP 0.411429 0.733333
68 GLY LYS ILE SER LYS HIS TRP THR GLY ILE 0.411043 0.787879
69 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.410811 0.723684
70 8LR GLY TRP TYR XSN 0.410596 0.702703
71 ASP ASN TRP GLN ASN GLY THR SER 0.409396 0.777778
72 GLY ILE TRP GLY PHE VAL PHE THR LEU 0.409091 0.806452
73 LYS ARG TRP ILE ILE MET GLY LEU ASN LYS 0.408284 0.69863
74 ALA ALA SER LEU TYR GLU LYS LYS ALA ALA 0.407143 0.730159
75 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.406897 0.7
76 GLN ALA SER GLN ASP VAL LYS ASN TRP 0.402597 0.769231
77 ALA LEU TRP GLY PHE VAL PRO VAL LEU 0.402439 0.757576
78 ASP TRP GLU ILE VAL 0.40146 0.704918
79 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.40146 0.676471
80 R38 0.4 0.706897
81 THR SER THR LEU GLN GLU GLN ILE GLY TRP 0.4 0.784615
82 ASP GLU LEU GLU ILE LYS ALA TYR 0.4 0.709677
83 R59 0.4 0.706897
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3RDV; Ligand: ASP SER TRP LYS ASP GLY CYS TYR; Similar sites found: 4
This union binding pocket(no: 1) in the query (biounit: 3rdv.bio4) has 15 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4N9I PCG 0.03573 0.41524 None
2 1KUV CA5 0.02698 0.41021 8.33333
3 2YVF NAD 0.04647 0.41993 9.72222
4 1B7H LYS NLE LYS 0.02796 0.41161 12.5
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