Receptor
PDB id Resolution Class Description Source Keywords
3TL0 2.05 Å EC: 3.1.3.48 STRUCTURE OF SHP2 N-SH2 DOMAIN IN COMPLEX WITH RLNPYAQLWHR P HOMO SAPIENS SH2 DOMAIN PROTEIN-PROTEIN INTERACTIONS PHOSPHORYLATED TYRHYDROLASE-PEPTIDE COMPLEX
Ref.: SIMULTANEOUS BINDING OF TWO PEPTIDYL LIGANDS BY A S HOMOLOGY 2 DOMAIN. BIOCHEMISTRY V. 50 7637 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ARG LEU ASN PTR ALA GLN LEU TRP HIS ARG B:200;
Valid;
none;
Kd = 0.26 uM
796.816 n/a P(=O)...
SO4 A:107;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3TL0 2.05 Å EC: 3.1.3.48 STRUCTURE OF SHP2 N-SH2 DOMAIN IN COMPLEX WITH RLNPYAQLWHR P HOMO SAPIENS SH2 DOMAIN PROTEIN-PROTEIN INTERACTIONS PHOSPHORYLATED TYRHYDROLASE-PEPTIDE COMPLEX
Ref.: SIMULTANEOUS BINDING OF TWO PEPTIDYL LIGANDS BY A S HOMOLOGY 2 DOMAIN. BIOCHEMISTRY V. 50 7637 2011
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 31 families.
1 3TL0 Kd = 0.26 uM ARG LEU ASN PTR ALA GLN LEU TRP HIS ARG n/a n/a
2 3TKZ Kd = 1.2 uM ARG VAL ILE PTR PHE VAL PRO LEU ASN ARG n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 28 families.
1 3TL0 Kd = 0.26 uM ARG LEU ASN PTR ALA GLN LEU TRP HIS ARG n/a n/a
2 3TKZ Kd = 1.2 uM ARG VAL ILE PTR PHE VAL PRO LEU ASN ARG n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 18 families.
1 3TL0 Kd = 0.26 uM ARG LEU ASN PTR ALA GLN LEU TRP HIS ARG n/a n/a
2 3TKZ Kd = 1.2 uM ARG VAL ILE PTR PHE VAL PRO LEU ASN ARG n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ARG LEU ASN PTR ALA GLN LEU TRP HIS ARG; Similar ligands found: 12
Similar Ligands (3D)
Ligand no: 1; Ligand: ARG LEU ASN PTR ALA GLN LEU TRP HIS ARG; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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