-->
Receptor
PDB id Resolution Class Description Source Keywords
3TLJ 2.2 Å EC: 2.1.1.- CRYSTAL STRUCTURE OF TRM14 FROM PYROCOCCUS FURIOSUS IN COMPL ADENOSYL-L-HOMOCYSTEINE PYROCOCCUS FURIOSUS ROSSMANN FOLD METHYLTRANSFERASE THUMP DOMAIN TRNA METHYLTRANSFERASE TRANSFERASE
Ref.: CRYSTAL STRUCTURES OF THE TRNA:M2G6 METHYLTRANSFERA TRM14/TRMN FROM TWO DOMAINS OF LIFE. NUCLEIC ACIDS RES. V. 40 5149 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACT A:402;
Invalid;
none;
submit data
59.044 C2 H3 O2 CC(=O...
SAH A:401;
B:401;
Valid;
Valid;
none;
none;
submit data
384.411 C14 H20 N6 O5 S c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3TLJ 2.2 Å EC: 2.1.1.- CRYSTAL STRUCTURE OF TRM14 FROM PYROCOCCUS FURIOSUS IN COMPL ADENOSYL-L-HOMOCYSTEINE PYROCOCCUS FURIOSUS ROSSMANN FOLD METHYLTRANSFERASE THUMP DOMAIN TRNA METHYLTRANSFERASE TRANSFERASE
Ref.: CRYSTAL STRUCTURES OF THE TRNA:M2G6 METHYLTRANSFERA TRM14/TRMN FROM TWO DOMAINS OF LIFE. NUCLEIC ACIDS RES. V. 40 5149 2012
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 3TM5 - SFG C15 H23 N7 O5 c1nc(c2c(n....
2 3TLJ - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 3TM4 - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 54 families.
1 3TM5 - SFG C15 H23 N7 O5 c1nc(c2c(n....
2 3TLJ - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 3TM4 - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 47 families.
1 3TM5 - SFG C15 H23 N7 O5 c1nc(c2c(n....
2 3TLJ - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 3TM4 - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3TLJ; Ligand: SAH; Similar sites found with APoc: 734
This union binding pocket(no: 1) in the query (biounit: 3tlj.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 1WUW TSU None
2 5O0Z 9GB None
3 5FEU NAP 0.687285
4 5FFF 5XC 0.77821
5 5FFF NAP 0.77821
6 4CS9 AMP 1.0582
7 2B4Q NAP 1.08696
8 3D3W NAP 1.22951
9 1PR9 NAP 1.22951
10 3S6X SIA GAL BGC 1.23077
11 4U8P UDP 1.34048
12 4U8P FDA 1.34048
13 2JAH NDP 1.34048
14 5MLR NAP 1.34048
15 5MLR GRQ 1.34048
16 1JQ3 AAT 1.35135
17 5DF1 NAP 1.3587
18 5DF1 58X 1.3587
19 2V6G NAP 1.37363
20 3QJ4 FAD 1.46199
21 2AE2 PTO 1.53846
22 2AE2 NAP 1.53846
23 2EWM NAD 1.60643
24 3RKR NAP 1.60858
25 2JB2 PHE 1.60858
26 2JB2 FAD 1.60858
27 5I39 FAD 1.60858
28 3K7M FAD 1.60858
29 6EOM ALA LYS 1.60858
30 4Z24 FAD 1.60858
31 2IV2 MGD 1.60858
32 2UYQ SAM 1.6129
33 5W7R SAH 1.6317
34 5W7R 9Z7 1.6317
35 1FZQ GDP 1.65746
36 3AB1 FAD 1.66667
37 1WVG APR 1.67131
38 5YJI 8WO 1.76056
39 5YJI SAH 1.76056
40 5YJF SAH 1.76056
41 5YJF 8WO 1.76056
42 4NTD FAD 1.76471
43 3U4C NDP 1.77936
44 3HB5 NAP 1.83486
45 4TQG NDP 1.85759
46 5JJR SAH 1.87668
47 4UCI SAM 1.87668
48 3L9W AMP 1.87668
49 3L9W GSH 1.87668
50 5F8F SFG 1.87668
51 5ZYN FAD 1.87668
52 4J0Q GDP 1.87668
53 4BJZ P3A 1.87668
54 4BJZ FAD 1.87668
55 3X0V FAD 1.87668
56 1CT9 AMP 1.87668
57 4AT0 FAD 1.87668
58 2YY7 NAD 1.92308
59 4HA6 FAD 1.9685
60 3MCT SAH 2.0202
61 4BV6 FAD 2.0284
62 6B92 SAH 2.04082
63 1R6D NAD 2.07715
64 1R6D DAU 2.07715
65 4ZCC NAI 2.08333
66 4ZCC FAD 2.08333
67 5Z75 NAD 2.14067
68 4N49 SAM 2.14477
69 5FWA J7C 2.14477
70 2Z3Y F2N 2.14477
71 3C6K SPD 2.14477
72 3C6K MTA 2.14477
73 4B63 NAP 2.14477
74 4B63 ORN 2.14477
75 4B63 FAD 2.14477
76 1GET FAD 2.14477
77 1GET NAP 2.14477
78 1KNR FAD 2.14477
79 5MZI FYK 2.14477
80 5MZI FAD 2.14477
81 5WS9 AMP 2.14477
82 1T9D 1MM 2.14477
83 1T9D P25 2.14477
84 3OZ2 FAD 2.14477
85 5WKC FAD 2.14477
86 1T9D FAD 2.14477
87 1T9D PYD 2.14477
88 5Y77 FAD 2.14477
89 6EL3 NAP 2.14477
90 1T9D P22 2.14477
91 6ER9 NAP 2.14477
92 6ER9 FAD 2.14477
93 3GD4 NAD 2.15264
94 3GD4 FAD 2.15264
95 5ME4 HP4 2.18978
96 4ITU NAI 2.23048
97 4ITU 1HS 2.23048
98 4C3Y FAD 2.26415
99 4C3Y ANB 2.26415
100 1H5Q NAP 2.26415
101 2P41 SAH 2.29508
102 1U7T TDT 2.29885
103 6CI9 NAP 2.3166
104 4Q9N NAI 2.34899
105 2WSB NAD 2.3622
106 1B74 DGN 2.3622
107 2Q46 NAP 2.37154
108 6GFK SAH 2.39044
109 5MW4 5JU 2.39521
110 2CFC NAD 2.4
111 3PT9 SAH 2.41287
112 2HQM FAD 2.41287
113 1RYI FAD 2.41287
114 3UOY FAD 2.41287
115 3UOY NAP 2.41287
116 1RYI GOA 2.41287
117 5HXI FAD 2.41287
118 1NAA ABL 2.41287
119 1NAA 6FA 2.41287
120 5WGR FAD 2.41287
121 1GPE FAD 2.41287
122 4MIG G3F 2.41287
123 5HSA FAS 2.41287
124 6H3O FAD 2.41287
125 5HXI 5HN 2.41287
126 1WD4 AHR 2.41287
127 1FP1 SAH 2.41935
128 5JGL SAM 2.42215
129 1ZBQ NAD 2.44648
130 3GCZ SAM 2.48227
131 1GZ6 NAI 2.50784
132 3SJU NDP 2.50896
133 5GWT NAD 2.51799
134 5GWT SIN 2.51799
135 3EVG SAH 2.54545
136 4A6D SAM 2.54958
137 3TKA SAM 2.59366
138 4JLV ADP 2.60223
139 5CUQ NSC 2.62172
140 2O07 SPD 2.63158
141 2O07 MTA 2.63158
142 4BWL MN9 2.63158
143 2WPB ZZI 2.63158
144 5NM7 GLY 2.63158
145 5N5D SAM 2.65487
146 5AHO TLA 2.67857
147 3VSE SAH 2.68097
148 3QOX SAH 2.68097
149 3HDY FAD 2.68097
150 1BDB NAD 2.68097
151 3HDY GDU 2.68097
152 3HDY FDA 2.68097
153 4RPL 3UC 2.68097
154 4RPL FAD 2.68097
155 5FJN FAD 2.68097
156 5FJN BE2 2.68097
157 1H82 FAD 2.68097
158 1H82 GZZ 2.68097
159 5VN0 FAD 2.68097
160 1FUR MLT 2.68097
161 5VN0 NAI 2.68097
162 5OC1 FAD 2.68097
163 4RVG TYD 2.68097
164 1ZGS XMM 2.68097
165 4RVG SAM 2.68097
166 2YVF NAD 2.68097
167 2YVF FAD 2.68097
168 3TKY SAH 2.71739
169 5FA5 MTA 2.7248
170 3H8V ATP 2.73973
171 1XTP SAI 2.75591
172 4DA6 GA2 2.7668
173 2OBF SAH 2.76817
174 2OBF F83 2.76817
175 4RDH AMP 2.77778
176 4RDI ATP 2.77778
177 1E1M FAD 2.82609
178 1E1M NAP 2.82609
179 1E6E FAD 2.82609
180 1XKQ NDP 2.85714
181 1UAY ADN 2.89256
182 1EXF GLY 2.89256
183 4D79 ATP 2.89855
184 4GQB 0XU 2.90698
185 1KYQ NAD 2.91971
186 6F7L FAD 2.94118
187 2EJU SAH 2.94906
188 4KRI SAH 2.94906
189 2IVD FAD 2.94906
190 4FWE FAD 2.94906
191 4GUT FAD 2.94906
192 4HSU FAD 2.94906
193 4GUS FAD 2.94906
194 4JDR FAD 2.94906
195 5KOX FAD 2.94906
196 5KOX RFP 2.94906
197 4EUE NAI 2.94906
198 5EZ7 FAD 2.94906
199 2C7G ODP 2.94906
200 1DMR PGD 2.94906
201 3NTD FAD 2.94906
202 2C7G FAD 2.94906
203 4EMI FAD 2.94906
204 4EMI NAD 2.94906
205 1YKJ PHB 2.94906
206 1YKJ FAD 2.94906
207 3NTA FAD 2.94906
208 1VL8 NAP 2.99625
209 3FZG SAM 3
210 3G2O SAM 3.01003
211 3THR C2F 3.07167
212 1ZGA SAH 3.08123
213 3O03 NAP 3.09278
214 4R6W PC 3.10078
215 4R6W SAH 3.10078
216 1D1Q 4NP 3.10559
217 3A4V NAD 3.15457
218 3A4V PYR 3.15457
219 1O5O U5P 3.16742
220 3ZV6 4HB 3.20285
221 3ZV6 NAD 3.20285
222 1V59 NAD 3.21716
223 2JHP SAH 3.21716
224 4X9M FAD 3.21716
225 1V59 FAD 3.21716
226 2WPF FAD 3.21716
227 2WPF WPF 3.21716
228 1LVL FAD 3.21716
229 4B2D FBP 3.21716
230 4YNU LGC 3.21716
231 4YNU FAD 3.21716
232 1LVL NAD 3.21716
233 5XWV 8H6 3.21716
234 5XWV NDP 3.21716
235 2WA2 SAM 3.26087
236 4YUW 4JU 3.28947
237 4YUW S4M 3.28947
238 4USR FAD 3.3241
239 6BWL NAD 3.35366
240 5MIT FAD 3.36391
241 5MIT NAP 3.36391
242 1IY8 NAD 3.37079
243 6GAR FAD 3.4384
244 1OC2 NAD 3.44828
245 1OC2 TDX 3.44828
246 4YAG NAI 3.46021
247 5J5Z FAD 3.48525
248 1MO9 FAD 3.48525
249 1MO9 KPC 3.48525
250 1Q9I FAD 3.48525
251 1Q9I TEO 3.48525
252 1E5Q NDP 3.48525
253 1D4D FAD 3.48525
254 3LAD FAD 3.48525
255 3UCL CYH 3.48525
256 3UCL FAD 3.48525
257 3UCL NAP 3.48525
258 5XLX SAH 3.48525
259 1YBH FAD 3.48525
260 5TWB FAD 3.48837
261 2EUG URA 3.49345
262 1GEG NAD 3.51562
263 1UDB UFG 3.5503
264 1UDB NAD 3.5503
265 5K7U SAM 3.55556
266 5YF1 SFG 3.59116
267 5YF1 8V0 3.59116
268 1V6A TRE 3.61446
269 1YXM ADE 3.63036
270 4XUC SAM 3.66972
271 4XUC 43G 3.66972
272 3ZFD ANP 3.7037
273 2ZFU SAH 3.72093
274 3CGB FAD 3.75
275 4E3Q PMP 3.75335
276 2IID PHE 3.75335
277 2IID FAD 3.75335
278 1Y8Q ATP 3.75335
279 1QO8 FAD 3.75335
280 3GDN HBX 3.75335
281 3GDN FAD 3.75335
282 2RAB FAD 3.75335
283 2RAB NAD 3.75335
284 5EB4 FAD 3.75335
285 5JCA FAD 3.75335
286 4KGD TDP 3.75335
287 5JCA NDP 3.75335
288 4KGD FAD 3.75335
289 3LXD FAD 3.75335
290 5IL1 SAM 3.77358
291 3COB ADP 3.79404
292 6ECU SAH 3.79747
293 5BJX UDP 3.82514
294 5BJX NAD 3.82514
295 4B47 GDP 3.85675
296 2X2T GAL NGA 3.92157
297 1JNR FAD 4
298 3S1S SAH 4.02145
299 3NYC FAD 4.02145
300 3NYC IAR 4.02145
301 2FR1 NDP 4.02145
302 3AXB PRO 4.02145
303 3AXB FAD 4.02145
304 3S5W FAD 4.02145
305 3KLJ FAD 4.02145
306 6AIN FAD 4.02145
307 2GVC FAD 4.02145
308 2GV8 FAD 4.02145
309 2BGM NAJ 4.02145
310 6FP4 E1T 4.02145
311 6FP4 FAD 4.02145
312 1VQW FAD 4.02145
313 6HSP COA 4.02145
314 2HT6 GDP 4.02299
315 5T2U NAP 4.03226
316 1ORR NAD 4.03458
317 2XG5 EC5 4.04624
318 2XG5 EC2 4.04624
319 3AY6 NAI 4.08922
320 3AY6 BGC 4.08922
321 2BD0 NAP 4.09836
322 5KXE 6Y2 4.11523
323 1EFV AMP 4.12698
324 1EFV FAD 4.12698
325 5FUB SAH 4.1543
326 4ZRN NAD 4.16667
327 3BXO SAM 4.1841
328 4ZDM GLY 4.21456
329 1GEE NAD 4.21456
330 3C3Y SAH 4.21941
331 5EJ2 NAD 4.22078
332 1BXK NAD 4.22535
333 2RGO FAD 4.28954
334 1ZK7 FAD 4.28954
335 4TM3 FAD 4.28954
336 2Y6Q I7T 4.28954
337 2Y6Q FAD 4.28954
338 1BZL FAD 4.28954
339 1BZL GCG 4.28954
340 2RGH FAD 4.28954
341 4G5H NAP 4.28954
342 4G5H UD7 4.28954
343 5FG3 GDP 4.28954
344 3FPZ AHZ 4.29448
345 4PIO SAH 4.33437
346 4PIO AVI 4.33437
347 3GMB FAD 4.33735
348 5O42 9JW 4.37956
349 5O42 NAD 4.37956
350 5O42 BGC 4.37956
351 3ABI NAD 4.38356
352 4AVV CD 4.41176
353 4AVV GHE 4.41176
354 3QWI NAP 4.44444
355 3QWI CUE 4.44444
356 6FDF SAH 4.49102
357 6DUB SAH 4.5045
358 1C3X 8IG 4.51128
359 3HVJ 705 4.52489
360 1SB8 NAD 4.54545
361 1SB8 UD2 4.54545
362 2PZM UDP 4.54545
363 2PZM NAD 4.54545
364 4HXY NDP 4.55764
365 3AKI AH8 4.55764
366 4RSL FAD 4.55764
367 2VVM FAD 4.55764
368 1U1J MET 4.55764
369 2VVL FAD 4.55764
370 4J1Q NDP 4.55764
371 3IHG FAD 4.55764
372 2NPX FAD 4.55764
373 2NPX NAD 4.55764
374 2WET FAD 4.55764
375 6HH6 A3R 4.55764
376 5N0J FAD 4.5584
377 4CQM NAP 4.5977
378 1NW5 SAM 4.70219
379 3AYI HCI 4.71567
380 3AYI FAD 4.71567
381 1RJW ETF 4.71976
382 5W7M SAH 4.80769
383 5THY SAH 4.82574
384 5XNC MTA 4.82574
385 3GF4 FAD 4.82574
386 3SQP FAD 4.82574
387 4IV9 FAD 4.82574
388 2BRY FAD 4.82574
389 3GF4 UPG 4.82574
390 4TXI FAD 4.82574
391 5K0A FAD 4.82574
392 1V8K ANP 4.82574
393 6DEN G8A 4.82574
394 6DEN TP9 4.82574
395 6DEN FAD 4.82574
396 5NMX FAD 4.82574
397 5NMX NAP 4.82574
398 1PDZ PGA 4.82574
399 4E70 N7I 4.82574
400 3QVP FAD 4.82574
401 4OM8 NAD 4.82574
402 2PS1 ORO 4.86726
403 3VYW SAM 4.87013
404 1EDO NAP 4.91803
405 2DTX BMA 4.92424
406 2PT9 2MH 4.98442
407 2PT9 S4M 4.98442
408 3CTY FAD 5.01567
409 2HNK SAH 5.02092
410 5KOK SAH 5.09383
411 6C8R SAH 5.09383
412 5KOK S9T 5.09383
413 5KOK R9T 5.09383
414 6C8R EQV 5.09383
415 5BVA FAD 5.09383
416 3MAG SAH 5.09383
417 1FEC FAD 5.09383
418 4MOP 2H5 5.09383
419 1RTF BEN 5.15873
420 2QBU SAH 5.17241
421 2AG5 NAD 5.28455
422 5Z2L NDP 5.30612
423 1T57 FMN 5.33981
424 1PN0 FAD 5.36193
425 1PN0 IPH 5.36193
426 3LZW NAP 5.36193
427 3LZW FAD 5.36193
428 4DCT GDP 5.36193
429 1GTE FAD 5.36193
430 3GWZ SAH 5.42005
431 3GXO SAH 5.42005
432 6BQ6 TER 5.43807
433 2AOT SAH 5.47945
434 1REO FAD 5.55556
435 2PXX SAH 5.5814
436 5DNK SAH 5.59567
437 1BW9 NAD 5.61798
438 3RFV 15L 5.61798
439 3RFV NAI 5.61798
440 5J60 FAD 5.625
441 5ERG SAM 5.63003
442 5BSZ SAH 5.63003
443 1UWK URO 5.63003
444 1UWK NAD 5.63003
445 3CGD FAD 5.63003
446 3CGD NAD 5.63003
447 3CGD COA 5.63003
448 4ZM4 PLP 5.63003
449 5FH7 5XL 5.64516
450 2I7C AAT 5.65371
451 3ELW SAM 5.66667
452 3ELW GP3 5.66667
453 2OWZ CIT 5.72289
454 1XHL NDP 5.72391
455 6GAS FAD 5.74018
456 3EVF SAH 5.77617
457 3EVF GTA 5.77617
458 2R4J FAD 5.89812
459 2R4J 13P 5.89812
460 4URF NAD 5.89812
461 5G3U ITW 5.89812
462 5G3U FDA 5.89812
463 5K4W NAI 5.919
464 5K4W THR 5.919
465 1ODJ GMP 5.95745
466 5ICE 2H4 5.96591
467 5ICE SAH 5.96591
468 4P86 5GP 6.01093
469 3FPF TNA 6.04027
470 3FPF MTA 6.04027
471 4P83 U5P 6.04396
472 3LCV SAM 6.04982
473 3WGT FAD 6.05187
474 3WGT QSC 6.05187
475 1QAN SAH 6.14754
476 3A27 SAM 6.16622
477 6GKV SAH 6.16622
478 1KYZ SAH 6.16622
479 3E1T FAD 6.16622
480 5MBX SP5 6.16622
481 5MBX FAD 6.16622
482 2IZ1 ATR 6.16622
483 6IS0 SAH 6.16622
484 1PJS NAD 6.16622
485 1KYZ FER 6.16622
486 2AQJ TRP 6.16622
487 2AQJ FAD 6.16622
488 2Q1W NAD 6.30631
489 1RP0 AHZ 6.33803
490 2VMG MBG 6.36943
491 1XCL SAH 6.38298
492 1X87 NAD 6.43432
493 3ML1 MGD 6.43432
494 2BZG SAH 6.46552
495 1ZEM NAD 6.48855
496 4POO SAM 6.5
497 4Y9D NAI 6.55738
498 1O97 AMP 6.5625
499 1O97 FAD 6.5625
500 4JLS 3ZE 6.57895
501 4DMG SAM 6.61578
502 5E1M SAH 6.639
503 5E1M PRO PRO LYS ARG ILE ALA 6.639
504 4CNK FAD 6.70241
505 5BUK FAD 6.70241
506 4XQC NAD 6.70241
507 2NVK FAD 6.70241
508 5UFN SAH 6.72269
509 5ZZ6 ADP 6.73077
510 1XSE NDP 6.77966
511 1I8T FAD 6.81199
512 3PFG TLO 6.84411
513 3PFG SAM 6.84411
514 1E3W NAD 6.89655
515 2VDV SAM 6.91057
516 1G60 SAM 6.92308
517 1E6W NAD 6.92308
518 5MPT SAH 6.97051
519 4LHD GLY 6.97051
520 2GN4 NDP 6.97051
521 2GN4 UD1 6.97051
522 5TS5 FAD 6.97051
523 2DKH FAD 6.97051
524 2DKH 3HB 6.97051
525 3NKS FAD 6.97051
526 3CH6 NAP 6.99301
527 3CH6 311 6.99301
528 1Z3C SA8 7.04698
529 4YAC NAI 7.07071
530 3ACC 5GP 7.18232
531 5THZ SAH 7.23861
532 5X62 SAH 7.23861
533 4M52 FAD 7.23861
534 6B3A SAM 7.23861
535 2A8X FAD 7.23861
536 1G55 SAH 7.28863
537 6ECW SAH 7.30159
538 3RJ5 NAD 7.48031
539 1XDS SAM 7.48663
540 4D7E FAD 7.5067
541 4USQ FAD 7.5067
542 2YG3 FAD 7.5067
543 4OPC FDA 7.5067
544 4IP7 FBP 7.5067
545 2Q28 ADP 7.5067
546 4C2C ALA ALA ALA 7.5067
547 3V1U NAD 7.5067
548 1JQD SAH 7.53425
549 1JQD HSM 7.53425
550 1P1C SAH 7.53769
551 1HGX 5GP 7.65027
552 1KPG SAH 7.66551
553 1I2B NAD 7.67327
554 1I2B USQ 7.67327
555 1I2B UPG 7.67327
556 1SVI GDP 7.69231
557 5OJI ISN 7.69231
558 5OJI NAP 7.69231
559 5THQ NDP 7.72059
560 2YX1 SFG 7.7381
561 1QZZ SAM 7.7748
562 4D04 FAD 7.7748
563 4D04 NAP 7.7748
564 1BC5 SAH 7.80669
565 3K7S R52 7.82123
566 5ULP KB1 7.83582
567 5BW4 SAM 7.86517
568 4J56 FAD 7.89474
569 1FIW PBZ 7.93103
570 4L2I FAD 7.98479
571 3JQA DX4 7.98611
572 1TPY SAH 8.01394
573 2CDU ADP 8.0429
574 2CDU FAD 8.0429
575 4REP FAD 8.0429
576 3LST SAH 8.04598
577 3BGD SAH 8.07692
578 3BGD PM6 8.07692
579 5G3L SIA 8.08081
580 1FP2 SAH 8.23864
581 3ICT FAD 8.31099
582 3ICS FAD 8.31099
583 3ICR FAD 8.31099
584 3ICT ADP 8.31099
585 1KPH SAH 8.36237
586 5YEC ATP 8.40336
587 6ECT SAM 8.41121
588 1NFQ NAI 8.46154
589 3GEG NAD 8.50202
590 1YQZ FAD 8.57909
591 4AZW SAM 8.57909
592 4D5G FAD 8.57909
593 4D5G TPP 8.57909
594 5U8U FAD 8.57909
595 3QFA FAD 8.62069
596 3WMX NAD 8.65922
597 4FN4 NAD 8.66142
598 4MO2 FDA 8.69565
599 4MO2 FAD 8.69565
600 2A14 SAH 8.74525
601 2QA1 FAD 8.84719
602 4QAR ADE 8.95522
603 5E9W SAH 8.97436
604 5E8J SAH 8.97436
605 5FTW SAH 8.98438
606 2ZIF SAM 9.09091
607 5MGZ SAH 9.11528
608 5KVA SAM 9.11528
609 5TTJ FAD 9.11528
610 1OAA OAA 9.26641
611 3A25 SAM 9.30233
612 3A28 NAD 9.30233
613 2UXR ICT 9.38338
614 4FC7 COA 9.38628
615 4FC7 NAP 9.38628
616 5GVR LMR 9.40171
617 1OSS BEN 9.41704
618 4LWP SAH 9.51087
619 2Q7V FAD 9.53846
620 4YSX FAD 9.57447
621 4RDN 6MD 9.58084
622 4KRG SAH 9.65147
623 3AFN NAP 9.68992
624 1XHC FAD 9.80926
625 5LOG SAH 9.87124
626 1U2Z SAH 9.91957
627 3NUG NAD 10.1215
628 1SQF SAM 10.1877
629 2DPM SAM 10.2113
630 5GWX SAR 10.2113
631 5GWX SAM 10.2113
632 3P9C SAH 10.4396
633 5HJM MTA 10.5114
634 5U19 827 10.5572
635 5U19 SAH 10.5572
636 1LSS NAD 10.7143
637 2ZUX RAM 10.7239
638 1COY FAD 10.7239
639 2GDZ NAD 10.8614
640 1G0N NDP 10.9541
641 1G0N PHH 10.9541
642 1ELI PYC 10.992
643 1JG3 ADN 11.0638
644 2JK0 ASP 11.0769
645 1XG5 NAP 11.1111
646 4K5S FAD 11.194
647 4K5S PM0 11.194
648 4NBU NAI 11.2
649 4KIB SAH 11.2045
650 3LKZ SFG 11.2601
651 2GAG FOA 11.2601
652 2GAG FAD 11.2601
653 2GAG NAD 11.2601
654 1I9G SAM 11.4286
655 4YMH SAH 11.6667
656 4BLW SAH 11.7647
657 4BLW AMP 11.7647
658 5BRT CH9 11.7962
659 5BRT FAD 11.7962
660 2E5V FAD 11.7962
661 5TUF FAD 11.7962
662 5TUF TDC 11.7962
663 1F3L SAH 11.838
664 3DXY SAM 11.9266
665 6ARJ BW4 12.0344
666 6ARJ SAH 12.0344
667 5DX8 SFG 12.0344
668 5DXA SFG 12.0344
669 5DX1 SFG 12.0344
670 5DWQ SFG 12.0344
671 5DX0 SFG 12.0344
672 5GM1 SAH 12.1212
673 3H2B SAH 12.3153
674 5KMS NAD 12.3324
675 5KMS FAD 12.3324
676 1AE1 NAP 12.4542
677 1YY5 FAD 12.6005
678 1RSG FAD 12.6005
679 5JCM FAD 12.8686
680 5JCM NAD 12.8686
681 5JCM ISD 12.8686
682 3Q87 SAM 12.9412
683 3LN9 FLC 12.9496
684 2XVM SAH 13.0653
685 1L1E SAH 13.2404
686 3MQ2 SAH 13.3028
687 4NEC SAH 13.4048
688 6C5B SAH 13.4897
689 2HMT NAI 13.8889
690 4OBW SAM 14.0078
691 2JBH 5GP 14.6667
692 3AD8 NAD 14.7783
693 3AD8 PYC 14.7783
694 3AD8 FAD 14.7783
695 2VT3 ATP 14.8837
696 5WP4 SAH 15.0134
697 1I1N SAH 15.0442
698 3LU1 NAD 15.3846
699 1VE3 SAM 15.4185
700 2WCI GSH 15.5556
701 3MB5 SAM 15.6863
702 1EK6 NAI 15.8046
703 1EK6 UPG 15.8046
704 6FLZ MMA 15.9722
705 2PX8 SAH 15.9851
706 4NTC FAD 16.1194
707 3P2E SAH 16.4444
708 3OU2 SAH 16.5138
709 3JWH SAH 16.5899
710 3T7S SAM 17.1642
711 2F5Z FAD 17.1875
712 4YRY FAD 17.3913
713 4YRY NAD 17.3913
714 1L3I SAH 17.7083
715 5W7K SAH 17.9487
716 6F97 FAD 17.9625
717 4LFL TG6 18.0233
718 6AR9 3L4 18.3824
719 1GY8 NAD 18.3879
720 4PNE SAH 18.8742
721 1DL5 SAH 19.3029
722 5JE0 SAH 20.2429
723 5JE0 AZ8 20.2429
724 1R18 SAH 20.7048
725 1Q0S SAH 21.2355
726 5L95 AMP 21.25
727 4II2 ATP 21.6867
728 4DCM SAM 21.9839
729 2PWY SAH 22.4806
730 5FA8 SAM 23.6025
731 2HXW FLC 23.6287
732 6F5Z SAH 25.1082
733 5E72 SAM 35.2601
734 3RNM FAD 39.6552
Pocket No.: 2; Query (leader) PDB : 3TLJ; Ligand: SAH; Similar sites found with APoc: 93
This union binding pocket(no: 2) in the query (biounit: 3tlj.bio2) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 4KWI 1TJ 1.52091
2 4KWI NAP 1.52091
3 4DSG FAD 1.60858
4 4DSG UDP 1.60858
5 3F8D FAD 1.85759
6 4A59 AMP 1.87668
7 5T67 JHZ 1.87668
8 5T67 SAH 1.87668
9 5GT9 NAP 1.90114
10 3WDM ADN 1.91571
11 1A27 NAP 2.07612
12 5GSN NAP 2.14477
13 5GSN FAD 2.14477
14 2OG2 MLI 2.22841
15 4OHU NAD 2.42215
16 4OHU 2TK 2.42215
17 5Y1G NAD 2.43902
18 5Y1G AKB 2.43902
19 4O0L NDP 2.54545
20 1A0J BEN 2.69058
21 2Q2V NAD 2.7451
22 2C5S AMP 2.94906
23 3KIH GDL 3.09278
24 2PK3 A2R 3.11526
25 1NJR XYL 3.16901
26 5JAQ NAI 3.21716
27 4B2D SER 3.21716
28 4EIP FAD 3.48525
29 5BSH PRO 3.61011
30 2RH4 EMO 3.61011
31 6B74 BEN 3.7037
32 1F74 NAY 3.75427
33 4L2H AR6 AR6 3.77358
34 1M32 PLP 3.82514
35 2WYV NAD 3.83142
36 1JJV ATP 3.8835
37 1DQN IMU 3.91304
38 4F8L AES 4.13793
39 1O6B ADP 4.14201
40 1U25 IHS 4.1543
41 4ZRN UPG 4.16667
42 2Q0L FAD 4.18006
43 2ATJ BHO 4.22078
44 4GLL NAD 4.45104
45 1Q1R FAD 4.55764
46 1RL4 BRR 4.78723
47 2EG7 OTD 4.89914
48 1RKX NAD 5.04202
49 4RP9 ASC 5.09383
50 3SJ7 NDP 5.15873
51 1MXH DHF 5.43478
52 1MXH NAP 5.43478
53 5D63 FUC GLA GLA 5.63003
54 2C31 ADP 5.63003
55 2C31 TZD 5.63003
56 5TP0 BRN 5.80357
57 5OOH 9ZZ 6.16622
58 5OOH NAP 6.16622
59 3UNN MET GLU ASP TPO GLN ALA ILE ASP 6.19469
60 3OID NDP 6.20155
61 2EXX NAP 6.20915
62 1FDJ 13P 6.33609
63 2JAP NDP 6.47773
64 2JKY 5GP 6.57277
65 4O1M NAD 6.66667
66 4XQC 13D 6.70241
67 5ZI9 FLC 6.92308
68 1V35 NAI 6.99088
69 2DKN NAI 7.05882
70 4D42 W0I 7.0922
71 4D42 NAP 7.0922
72 4M52 M52 7.23861
73 4OPC PGT 7.5067
74 4K26 NDP 7.97101
75 4K26 SFF 7.97101
76 5VJN IR8 8.02139
77 1FP2 HMO 8.23864
78 3ICS ADP 8.31099
79 4NBT NAD 8.75
80 2XVF FAD 9.65147
81 2XVE FAD 9.65147
82 1COY AND 10.7239
83 6F9Q NAD 11.3971
84 4RI6 GSH 11.6279
85 4JNA FAD 12.0588
86 4LOC OXM 12.0643
87 3MB3 MB3 12.5926
88 1JQY A32 12.6214
89 5OVK NDP 12.8906
90 3TN7 NJP 13.2296
91 4EMJ FAD 14.0187
92 1NNU NAD 38.3333
93 1NNU TCT 38.3333
APoc FAQ
Feedback