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Receptor
PDB id Resolution Class Description Source Keywords
3TTI 2.2 Å EC: 2.7.11.24 CRYSTAL STRUCTURE OF JNK3 COMPLEXED WITH CC-930, AN ORALLY A ANTI-FIBROTIC JNK INHIBITOR HOMO SAPIENS MITOGEN-ACTIVATED PROTEIN KINASE 10 JNK3 PROTEIN KINASE INKINASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: DISCOVERY OF CC-930, AN ORALLY ACTIVE ANTI-FIBROTIC INHIBITOR. BIOORG.MED.CHEM.LETT. V. 22 1433 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:466;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
KBI A:465;
Valid;
none;
ic50 = 0.006 uM
448.442 C21 H23 F3 N6 O2 c1c(c...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3TTI 2.2 Å EC: 2.7.11.24 CRYSTAL STRUCTURE OF JNK3 COMPLEXED WITH CC-930, AN ORALLY A ANTI-FIBROTIC JNK INHIBITOR HOMO SAPIENS MITOGEN-ACTIVATED PROTEIN KINASE 10 JNK3 PROTEIN KINASE INKINASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: DISCOVERY OF CC-930, AN ORALLY ACTIVE ANTI-FIBROTIC INHIBITOR. BIOORG.MED.CHEM.LETT. V. 22 1433 2012
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 3TTI ic50 = 0.006 uM KBI C21 H23 F3 N6 O2 c1c(cc(c(c....
2 3TTJ ic50 = 0.21 uM JBI C23 H23 F N6 O COc1ccc(cc....
3 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
70% Homology Family (44)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 3TTI ic50 = 0.006 uM KBI C21 H23 F3 N6 O2 c1c(cc(c(c....
2 3TTJ ic50 = 0.21 uM JBI C23 H23 F N6 O COc1ccc(cc....
3 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
4 4H3B Kd = 17.2 uM VAL VAL ARG PRO GLY SER LEU ASP LEU PRO n/a n/a
5 3KVX ic50 = 0.148 uM FMY C26 H27 F N8 O2 c1cc(ccc1/....
6 4H39 Kd = 0.8 uM PRO LYS ARG PRO THR THR LEU ASN LEU PHE n/a n/a
7 4AWI ic50 = 1 uM AQ2 C21 H25 N3 O4 S2 CC(C)c1cc2....
8 2O0U ic50 = 3.2 uM C0M C27 H28 N4 O2 S c1ccc2c(c1....
9 2P33 ic50 = 57 nM J07 C20 H23 Cl N6 O CCNC(=O)N1....
10 2ZDU - 446 C28 H23 Br N2 O6 COC(=O)C1=....
11 2B1P ic50 = 3 nM AIZ C26 H26 Cl N5 O3 CN(C)CCCC(....
12 2OK1 Ki = 0.55 uM 33A C21 H17 Cl N4 O c1ccc(cc1)....
13 3OXI ic50 = 2.2 uM SYY C12 H11 N O3 S2 COC(=O)c1c....
14 3OY1 ic50 = 0.016 uM 589 C28 H31 N5 O2 c1ccc2cc(c....
15 6EMH ic50 = 833 nM BGE C19 H21 N5 O Cc1c([nH]c....
16 2ZDT - 46C C26 H20 Cl N O4 CCC(=O)C1=....
17 3ELJ - GS7 C22 H21 F N6 O4 S COc1cc(ccc....
18 3FI2 ic50 = 0.025 uM JK1 C26 H25 N5 O5 COc1cc(cc(....
19 4L7F ic50 = 160 nM 1V5 C26 H26 F N5 O2 c1cc(ccc1C....
20 6EQ9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
21 2WAJ ic50 = 0.398 uM SNB C16 H13 Br Cl N O COc1cc2c(c....
22 4QTD ic50 = 1080 nM 38Z C33 H33 N9 O2 c1cnc(nc1)....
23 6EKD ic50 = 184 nM B9K C20 H23 N5 O S Cc1c([nH]c....
24 3G9L Ki = 0.74 uM J67 C25 H19 F N2 O4 c1ccc(cc1)....
25 4Y46 ic50 = 11 nM 4F2 C22 H32 N6 O2 CC(C)NC(=O....
26 1PMN ic50 = 7.1 nM 984 C25 H30 Cl2 N6 CCCn1c(c(n....
27 3FI3 ic50 = 12 nM JK2 C29 H25 F N4 O4 COc1cc(cc(....
28 2O2U ic50 = 4 uM 738 C16 H13 F N2 O S c1ccc(c(c1....
29 4W4V ic50 = 866 nM 3H8 C23 H19 Cl N6 O2 Cc1cc(ccn1....
30 3DA6 - BZ9 C28 H23 N7 O Cc1cc(c2cc....
31 2R9S ic50 = 0.15 uM 255 C24 H24 N4 O2 S CC(C)(C)NS....
32 4Y5H ic50 = 15 nM 519 C20 H30 N6 O2 CC(C)NC(=O....
33 4X21 Kd = 36 nM 3WH C20 H23 I N6 O CCNC(=O)N1....
34 3RTP ic50 = 7 nM 34I C18 H14 N6 O2 S c1ccc2c(c1....
35 3PZE - CFK C12 H11 N3 O2 S c1ccc(cc1)....
36 4Z9L ic50 = 1.6 nM 880 C27 H34 Cl2 N6 CCCn1c(c(n....
37 4WHZ ic50 < 1 nM 3NL C24 H23 Cl N8 O2 c1ccc(c(c1....
38 4W4Y ic50 = 3034 nM 3HQ C24 H22 N6 O2 Cc1ccc(cc1....
39 4W4W ic50 = 6630 nM 3HJ C23 H20 N6 O2 Cc1cc(ccn1....
40 3G90 Ki = 0.44 uM J72 C17 H12 F2 N2 O4 c1cc2c(cc1....
41 1PMV ic50 = 150 nM 537 C14 H8 N2 O c1ccc2c(c1....
42 5AWM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
43 3NPC - B96 C31 H37 N5 O3 Cc1ccc(cc1....
44 3E7O ic50 = 120 nM 35F C20 H14 N6 O2 c1cc(cc(c1....
50% Homology Family (281)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 4FBX - 0TJ GLY ASP ASP ASP ASP ASP n/a n/a
2 5OUU - AWN C22 H20 Cl N3 c1ccc(cc1)....
3 4RLL - E91 C21 H14 N2 O2 c1ccc2c(c1....
4 5CU4 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
5 4O6E ic50 = 1 nM 2SH C21 H25 Cl F N5 O3 c1cc(c(cc1....
6 5NHJ ic50 < 0.0003 uM 8XE C18 H21 N7 O2 Cn1c(ccn1)....
7 4QYY Kd = 0.05 uM 3G7 C25 H29 Cl N4 O4 CC(=O)c1cc....
8 4I5H Ki < 2 nM G17 C26 H21 F3 N4 O Cc1ccc(cc1....
9 6G93 ic50 = 11 nM EU2 C17 H17 Cl N4 O2 c1cc2c(cc1....
10 4QTE Kd = 0.084 uM 390 C24 H20 Cl2 F N5 O2 Cc1cnc(nc1....
11 4XNE - TT4 C8 H9 N5 c1ccc(cc1)....
12 3QYW - 6PB C11 H8 Br N5 c1cc(cc(c1....
13 5BUE ic50 = 0.003 uM 4V8 C23 H21 N5 O c1ccc(cc1)....
14 6GE0 ic50 = 2.1 nM EVQ C28 H30 Cl N5 O4 C[C@H](c1c....
15 6G9N ic50 = 3 nM ESN C29 H32 Cl N5 O4 Cc1cccc(c1....
16 2Z7L - S91 C20 H19 N5 O3 Cc1cccc(c1....
17 4ZXT - CAQ C6 H6 O2 c1ccc(c(c1....
18 1WZY ic50 = 0.56 uM F29 C21 H17 N7 C=CCn1c2c(....
19 6DMG - EK6 C27 H26 Cl2 F N5 O4 CCOC(=O)CN....
20 5NHH ic50 < 0.00113 uM 8XH C19 H25 N5 O3 COCCN1CCc2....
21 6G9H ic50 = 4 nM ERW C24 H30 Cl N5 O3 CC(C)(C)N(....
22 4N4S - 2H1 C25 H24 N6 O Cc1cc(cc2c....
23 4QP8 ic50 = 0.28 uM 362 C14 H10 N6 c1cc(cnc1)....
24 4QP4 - 36O C11 H15 N5 c1[nH]c2c(....
25 6G9D ic50 = 4.3 nM ER8 C23 H28 Cl N5 O3 CC(C)(C)NC....
26 6GJB ic50 = 0.008 uM F0H C35 H34 Cl F N6 O4 c1cc(c(cc1....
27 6G91 ic50 = 3200 nM EQW C9 H12 Cl N3 O c1c(cnc(n1....
28 6G8X - EQT C7 H6 Cl N3 c1cc2c(c(c....
29 6DCG ic50 = 7 nM G67 C37 H41 N9 O3 S CC(C)Oc1cc....
30 4QP9 ic50 = 0.071 uM 35X C17 H16 N6 CCCn1cc(cn....
31 5BVE ic50 = 0.01 nM 4VG C25 H28 Cl N5 O3 c1cc(cc(c1....
32 5KE0 - 6S9 C20 H18 N6 O Cc1cc(ccn1....
33 6CPW ic50 = 5.6 nM F8V C35 H35 F N8 O2 S CS[C@]1(CC....
34 4XOY - DX4 C5 H5 N5 S c1[nH]c2c(....
35 6G9K - ESK C27 H28 Cl N5 O4 c1ccc(cc1)....
36 3QYZ - Z8B C10 H11 Br N8 O3 c1nc(c2c(n....
37 5BVF ic50 = 0.19 nM 4VJ C25 H28 Cl N5 O3 c1cc(cc(c1....
38 6G9M ic50 = 7.9 nM ESW C28 H30 Cl N5 O3 CC(C)(c1cc....
39 4XOZ - 620 C15 H16 N6 O c1ccc(cc1)....
40 5HD7 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
41 4XRJ - 620 C15 H16 N6 O c1ccc(cc1)....
42 2OJJ Ki = 0.002 uM 82A C22 H17 Cl2 F N4 O2 c1cc(cc(c1....
43 4QTA Kd = 0.013 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
44 5NHO ic50 < 0.0003 uM 8XN C20 H25 N7 O2 Cc1cnc(nc1....
45 2OJG Ki = 2.3 uM 19A C16 H16 N4 O CN(C)C(=O)....
46 4XP0 - 42A C8 H5 N3 c1cc2c(c[n....
47 4QP2 Kd = 940 uM 36R C7 H5 Cl N2 O c1cc2c(cc1....
48 5NHF ic50 = 0.0012 uM 8X5 C23 H25 N5 O2 c1ccc(cc1)....
49 5BUJ ic50 = 0.005 uM 4VB C16 H15 N5 O c1cnccc1c2....
50 6G9J ic50 = 4.1 nM ERK C27 H28 Cl N5 O3 C[C@H](c1c....
51 5BUI ic50 = 0.089 uM 4V9 C17 H15 F N4 c1ccnc(c1)....
52 4QP7 ic50 = 5.9 uM 363 C9 H7 N5 c1c[nH]c2c....
53 3ERK ic50 = 18 uM SB4 C18 H19 F N6 c1cc(ccc1c....
54 6GDQ - EVK C21 H22 Cl2 N4 O2 CC(C)Nc1cc....
55 5V60 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
56 1TVO Ki = 0.14 uM FRZ C18 H13 N7 c1ccc(cc1)....
57 6G9A ic50 = 21 nM ESQ C23 H28 Cl N5 O3 c1cc2c(cc1....
58 5BVD ic50 = 0.16 nM 4VF C24 H26 Cl N5 O3 c1cc(cc(c1....
59 4ZZN ic50 = 0.26 uM CQ8 C18 H21 Cl N4 O2 CNC(=O)c1c....
60 3SA0 - NRA C13 H8 O6 c1c(cc2c(c....
61 4ERK ic50 = 27 uM OLO C15 H18 N6 O Cn1cnc2c1n....
62 6GJD ic50 = 0.022 uM F0E C46 H55 N11 O5 c1cnc(nc1)....
63 5U6I - 81Y C19 H22 N4 O2 CC(C)Oc1cc....
64 5NHV ic50 = 0.0028 uM 8QB C16 H19 N5 O2 c1cnc(nc1c....
65 3I5Z Ki = 2 nM Z48 C24 H23 N5 O2 Cc1cnc(nc1....
66 4N0S - DHC C9 H8 O4 c1cc(c(cc1....
67 5NHP ic50 = 0.023 uM 8XK C19 H23 N7 O2 Cn1c(ccn1)....
68 3I60 Ki < 2 nM E86 C24 H22 Cl N5 O2 Cc1cnc(nc1....
69 4XP2 - TT4 C8 H9 N5 c1ccc(cc1)....
70 1PME Ki = 0.76 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
71 5NHL ic50 < 0.0003 uM 8XB C20 H25 N7 O2 Cc1cnc(nc1....
72 5HD4 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
73 6G97 ic50 = 4.2 nM EQZ C20 H23 Cl N4 O3 COCCN1Cc2c....
74 6G92 ic50 = 76000 nM ERZ C10 H13 N5 Cc1cnc(nc1....
75 5K4I ic50 = 3.1 nM 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
76 4FA2 - SB0 C20 H21 F N4 O2 COc1nccc(n....
77 2GHM - LIC C24 H28 Cl N5 O3 C[C@@H](C(....
78 1W84 ic50 = 35 uM L12 C15 H14 N2 c1ccc2c(c1....
79 4EH5 - IRG C17 H16 N4 c1ccc(cc1)....
80 2BAK Kd = 37 nM AQZ C32 H37 N7 O4 Cc1ccc(cc1....
81 3HV6 ic50 = 5500 nM R39 C27 H35 N5 O3 Cc1ccc(cc1....
82 3HP2 - P36 C19 H16 Br N O2 c1ccc(cc1)....
83 1WBO ic50 = 1 mM 2CH C6 H5 Cl O c1ccc(c(c1....
84 4KIQ ic50 = 23 nM 1RA C23 H23 N3 O4 CCOC(=O)n1....
85 3GC7 ic50 = 0.4 nM B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
86 4EH6 - IRG C17 H16 N4 c1ccc(cc1)....
87 5MTX Kd = 17.7 nM FJI C34 H31 F N4 O5 c1ccc(cc1)....
88 2ZB0 Ki = 0.24 uM GK3 C24 H18 N4 O2 Cc1ccc(cc1....
89 2GTM ic50 = 542 nM LID C19 H15 Cl F2 N6 CCn1c2c(cn....
90 5N66 - B96 C31 H37 N5 O3 Cc1ccc(cc1....
91 2YIX Kd = 3.3 nM YIX C19 H23 N5 O S CCNC(=O)NC....
92 3OCG ic50 = 3 nM OCG C21 H18 N6 O3 Cc1ccc(cc1....
93 1BL7 - SB4 C18 H19 F N6 c1cc(ccc1c....
94 3P7C ic50 = 0.022 uM P7C C25 H33 Cl2 N5 O3 S CC(C)(C)c1....
95 5TBE Kd = 4.4 nM 78L C33 H30 F2 N4 O4 S c1cc(sc1)C....
96 4KIP ic50 = 7 nM 1R9 C21 H18 Cl N3 O2 S Cc1ccc(cc1....
97 2EWA - SB2 C21 H16 F N3 O S C[S@](=O)c....
98 2GHL - LIB C23 H26 Cl N5 O3 C[C@@H](C(....
99 1ZZ2 ic50 = 6 uM B11 C24 H26 F N3 O4 S c1ccc(c(c1....
100 3ZSI - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
101 2YIW - YIW C30 H33 N7 O S CC(C)c1nnc....
102 5WJJ ic50 = 5.4 nM AQY C25 H19 F N6 O2 Cc1cc(ccc1....
103 1A9U - SB2 C21 H16 F N3 O S C[S@](=O)c....
104 1M7Q ic50 = 2.6 nM DQO C24 H20 Cl2 F2 N4 O c1cc(c(c(c....
105 5MTY Kd = 1.3 nM HB9 C29 H23 F2 N3 O4 S c1cc(sc1)C....
106 4EH7 - IRG C17 H16 N4 c1ccc(cc1)....
107 1YQJ ic50 = 7.3 nM 6NP C30 H27 N5 c1ccc(cc1)....
108 4EH3 - NAR C15 H12 O5 c1cc(ccc1[....
109 4AA5 ic50 = 6.7 nM NQB C24 H27 N5 O2 Cc1ccc(cc1....
110 1OVE ic50 = 0.74 nM 358 C26 H22 Cl2 F2 N2 O c1cc(c(c(c....
111 3UVP ic50 = 0.035 uM 048 C24 H21 F N2 O2 c1ccc(cc1)....
112 5N67 - 8ON C28 H30 N6 O CC(=O)N1CC....
113 3NNV ic50 = 27 nM 437 C25 H26 N4 O2 CC(C)(C)c1....
114 3CTQ ic50 = 40 nM 337 C30 H34 N6 O5 S Cc1ccc(cc1....
115 3IW7 - IPK C26 H26 N4 O S c1ccc(cc1)....
116 3ITZ ic50 = 1.4 nM P66 C21 H15 Cl F2 N6 O c1cc(c(c(c....
117 2ZB1 Ki = 0.48 uM GK4 C21 H21 N3 O2 Cc1ccc(cc1....
118 3HV5 ic50 = 150 nM R24 C30 H29 N7 O3 Cc1ccc(cc1....
119 1WBW ic50 = 44 uM LI4 C16 H14 N2 O c1ccc2c(c1....
120 3P79 ic50 = 2.3 uM P79 C24 H29 N5 O4 S CC(C)(C)c1....
121 3HV7 ic50 = 90 nM 1AU C24 H25 N5 O CC(C)(C)c1....
122 3GFE ic50 = 3.2 nM P37 C24 H21 F2 N5 O2 Cc1ccc(cc1....
123 3ZYA - 2A8 C21 H18 N2 O c1ccc2c(c1....
124 2RG5 ic50 = 3.1 nM 279 C19 H22 N6 O3 CCNC(=O)c1....
125 3L8X ic50 = 10 nM N4D C20 H18 N6 O Cc1ccc(cc1....
126 3GCS Kd = 56 nM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
127 3ZS5 - SB2 C21 H16 F N3 O S C[S@](=O)c....
128 3D83 Ki = 4.4 nM GK6 C28 H30 N4 O3 Cc1ccc(cc1....
129 1YW2 ic50 = 141 nM PGJ C22 H18 F N3 O5 CCOC[N@]1C....
130 1W82 ic50 = 196 nM L10 C20 H21 Cl N4 O CC(C)(C)C1....
131 3ZSG - T75 C24 H21 N3 O S CCc1nc(c(s....
132 5TCO Kd = 3.14 nM 79Q C35 H33 F N4 O4 c1ccc(cc1)....
133 4EH8 - IRG C17 H16 N4 c1ccc(cc1)....
134 3GCP Kd = 15 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
135 3HLL Ki = 0.0058 uM I45 C22 H19 Br F2 N2 O3 Cc1ccc(cc1....
136 1ZZL ic50 = 5 nM TZY C18 H15 F N4 O CC(C)c1nnc....
137 2RG6 ic50 = 2.2 nM 287 C25 H26 N6 O3 Cc1ccc(cc1....
138 3MPT ic50 = 0.25 uM 1GK C18 H16 N2 O3 Cc1ccccc1C....
139 1BL6 - SB6 C18 H16 F N3 c1cc(ccc1c....
140 3NNW ic50 = 9 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
141 3GI3 Kd < 1.8 nM B10 C33 H39 N5 O5 S CC(C)(C)c1....
142 3K3J - I46 C14 H9 F2 N3 c1cc(ccc1c....
143 3HEC ic50 = 70 uM STI C29 H31 N7 O Cc1ccc(cc1....
144 1IAN - D13 C21 H16 I N3 O S C[S@@](=O)....
145 3FC1 - 52P C19 H9 Cl2 F2 N3 O S c1cc(c(c(c....
146 3MVM ic50 = 13 nM 39P C22 H23 N7 O3 CCCNC(=O)c....
147 3NNU ic50 = 48 nM EDB C22 H17 Cl2 N5 O2 S c1cc(cc(c1....
148 1W7H ic50 = 1 mM 3IP C12 H12 N2 O c1ccc(cc1)....
149 3U8W ic50 = 1 nM 09J C24 H21 Cl F N5 O2 CCN1C(=O)C....
150 1WBS ic50 = 0.63 uM LI2 C26 H25 F N4 O2 c1cc2c(cc1....
151 4E6C Kd ~ 15 uM 0O8 C25 H53 N O4 P CCCCCCCCCC....
152 5N68 - 8OK C26 H27 N5 O c1ccc(cc1)....
153 1WBV ic50 = 162 uM LI3 C19 H18 F N3 O2 c1cc2c(cc[....
154 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
155 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
156 3HEG ic50 = 0.057 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
157 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
158 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
159 5ML5 ic50 = 10 nM 1VI C26 H25 F N4 O3 S COc1ccc(c(....
160 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
161 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
162 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
163 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
164 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
165 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
166 4A9Y - RNY C32 H37 N7 O4 Cc1ccc(cc1....
167 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
168 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
169 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
170 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
171 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
172 3BV2 Ki = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
173 4R3C - GG5 C14 H10 F N3 c1cc(ccc1c....
174 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
175 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
176 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
177 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COc1c(cc2c....
178 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
179 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
180 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
181 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
182 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
183 3BX5 ic50 = 1.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
184 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
185 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
186 5N63 - 8OW C21 H17 F N4 c1ccc(cc1)....
187 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
188 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
189 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
190 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
191 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
192 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
193 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
194 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
195 3IPH Ki = 0.0000251 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
196 5MZ3 ic50 = 0.00021 uM 8EN C24 H19 F3 N4 O2 Cc1ccc(cc1....
197 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
198 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
199 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
200 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
201 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
202 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
203 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
204 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
205 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
206 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
207 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
208 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
209 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
210 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
211 6ANL ic50 = 240 nM T75 C24 H21 N3 O S CCc1nc(c(s....
212 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
213 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
214 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
215 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
216 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
217 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
218 5XYY ic50 = 9.221 uM P0F C15 H12 Cl F N4 O c1cc(cc(c1....
219 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
220 4AAC ic50 = 16 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
221 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
222 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
223 5N64 - 8OH C19 H16 N4 S c1ccc(cc1)....
224 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
225 3TTI ic50 = 0.006 uM KBI C21 H23 F3 N6 O2 c1c(cc(c(c....
226 3TTJ ic50 = 0.21 uM JBI C23 H23 F N6 O COc1ccc(cc....
227 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
228 3KVX ic50 = 0.148 uM FMY C26 H27 F N8 O2 c1cc(ccc1/....
229 4H39 Kd = 0.8 uM PRO LYS ARG PRO THR THR LEU ASN LEU PHE n/a n/a
230 4AWI ic50 = 1 uM AQ2 C21 H25 N3 O4 S2 CC(C)c1cc2....
231 2O0U ic50 = 3.2 uM C0M C27 H28 N4 O2 S c1ccc2c(c1....
232 2P33 ic50 = 57 nM J07 C20 H23 Cl N6 O CCNC(=O)N1....
233 2ZDU - 446 C28 H23 Br N2 O6 COC(=O)C1=....
234 2B1P ic50 = 3 nM AIZ C26 H26 Cl N5 O3 CN(C)CCCC(....
235 2OK1 Ki = 0.55 uM 33A C21 H17 Cl N4 O c1ccc(cc1)....
236 3OXI ic50 = 2.2 uM SYY C12 H11 N O3 S2 COC(=O)c1c....
237 3OY1 ic50 = 0.016 uM 589 C28 H31 N5 O2 c1ccc2cc(c....
238 6EMH ic50 = 833 nM BGE C19 H21 N5 O Cc1c([nH]c....
239 2ZDT - 46C C26 H20 Cl N O4 CCC(=O)C1=....
240 3ELJ - GS7 C22 H21 F N6 O4 S COc1cc(ccc....
241 3FI2 ic50 = 0.025 uM JK1 C26 H25 N5 O5 COc1cc(cc(....
242 4L7F ic50 = 160 nM 1V5 C26 H26 F N5 O2 c1cc(ccc1C....
243 6EQ9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
244 2WAJ ic50 = 0.398 uM SNB C16 H13 Br Cl N O COc1cc2c(c....
245 4QTD ic50 = 1080 nM 38Z C33 H33 N9 O2 c1cnc(nc1)....
246 6EKD ic50 = 184 nM B9K C20 H23 N5 O S Cc1c([nH]c....
247 3G9L Ki = 0.74 uM J67 C25 H19 F N2 O4 c1ccc(cc1)....
248 4Y46 ic50 = 11 nM 4F2 C22 H32 N6 O2 CC(C)NC(=O....
249 1PMN ic50 = 7.1 nM 984 C25 H30 Cl2 N6 CCCn1c(c(n....
250 3FI3 ic50 = 12 nM JK2 C29 H25 F N4 O4 COc1cc(cc(....
251 2O2U ic50 = 4 uM 738 C16 H13 F N2 O S c1ccc(c(c1....
252 4W4V ic50 = 866 nM 3H8 C23 H19 Cl N6 O2 Cc1cc(ccn1....
253 3DA6 - BZ9 C28 H23 N7 O Cc1cc(c2cc....
254 2R9S ic50 = 0.15 uM 255 C24 H24 N4 O2 S CC(C)(C)NS....
255 4Y5H ic50 = 15 nM 519 C20 H30 N6 O2 CC(C)NC(=O....
256 4X21 Kd = 36 nM 3WH C20 H23 I N6 O CCNC(=O)N1....
257 3RTP ic50 = 7 nM 34I C18 H14 N6 O2 S c1ccc2c(c1....
258 3PZE - CFK C12 H11 N3 O2 S c1ccc(cc1)....
259 4Z9L ic50 = 1.6 nM 880 C27 H34 Cl2 N6 CCCn1c(c(n....
260 4WHZ ic50 < 1 nM 3NL C24 H23 Cl N8 O2 c1ccc(c(c1....
261 4W4Y ic50 = 3034 nM 3HQ C24 H22 N6 O2 Cc1ccc(cc1....
262 4W4W ic50 = 6630 nM 3HJ C23 H20 N6 O2 Cc1cc(ccn1....
263 3G90 Ki = 0.44 uM J72 C17 H12 F2 N2 O4 c1cc2c(cc1....
264 1PMV ic50 = 150 nM 537 C14 H8 N2 O c1ccc2c(c1....
265 3GC8 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
266 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
267 2PVH Ki = 0.26 uM P19 C17 H14 N6 c1ccc(cc1)....
268 5BYZ ic50 = 0.042 uM 4WE C25 H32 F N7 O Cc1ncc(n1C....
269 4ZSJ ic50 = 2.3 uM 4R0 C13 H17 Cl N6 O Cc1cc(ccc1....
270 4ZSG - 4QX C12 H15 Cl N6 O CC(C)NC(=O....
271 2F9G - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
272 2B9F - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
273 5AWM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
274 4EYM - 0RX C21 H20 N4 O3 c1cc(ccc1N....
275 5EKO ic50 = 15785 nM N17 C22 H18 N4 O2 Cc1cn(cn1)....
276 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
277 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
278 4QTB Kd = 0.084 uM 38Z C33 H33 N9 O2 c1cnc(nc1)....
279 2ZOQ ic50 = 0.9 uM 5ID C11 H13 I N4 O4 c1c(c2c(nc....
280 3NPC - B96 C31 H37 N5 O3 Cc1ccc(cc1....
281 3E7O ic50 = 120 nM 35F C20 H14 N6 O2 c1cc(cc(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: KBI; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 KBI 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3TTI; Ligand: KBI; Similar sites found with APoc: 567
This union binding pocket(no: 1) in the query (biounit: 3tti.bio1) has 28 residues
No: Leader PDB Ligand Sequence Similarity
1 4C5N ACP 1.08696
2 4C5N PXL 1.08696
3 5LUN OGA 1.13636
4 5YJS SAL 1.28205
5 5JIL 6KL 1.28866
6 5OES ADP 1.50862
7 4WOE ADP 1.50862
8 2HGS ADP 1.50862
9 1GPM AMP 1.50862
10 1H82 FAD 1.50862
11 1H82 GZZ 1.50862
12 5HWV MBN 1.53846
13 3WVR AMP 1.566
14 2WBV SIA 1.5873
15 2PYW ADP 1.66667
16 2CFM AMP 1.72414
17 5JBE MAL 1.72414
18 2BMB PMM 1.72414
19 4UWH JXM 1.72414
20 3ZJX BOG 1.7301
21 2I4O ATP 1.74672
22 2VPQ ANP 1.77384
23 2J83 BAT 1.9084
24 3UDZ ADP 1.93966
25 6FL8 TIY 1.93966
26 6FL8 ADP 1.93966
27 3HNC TTP 1.93966
28 6EOM ALA LYS 1.93966
29 6C1S EFV 1.93966
30 5EQY 5RA 1.99501
31 2YRX AMP 1.99557
32 1U6R IOM 2.10526
33 1U6R ADP 2.10526
34 4OCJ NDG 2.11082
35 1EHI ADP 2.12202
36 3WO0 ALA 2.15517
37 3WO0 ADP 2.15517
38 4YRI 4JH 2.19298
39 1SDW IYT 2.2293
40 1AUX AGS 2.2508
41 1I7L ATP 2.26537
42 5I35 ANP 2.29008
43 6BOX SAH 2.31023
44 2Z49 AMG 2.31481
45 2Z48 A2G 2.31481
46 1PK8 ATP 2.36967
47 4IV9 TSR 2.37069
48 4IP7 FLC 2.37069
49 4NPL AKG 2.4
50 4MOB ADP 2.40964
51 1S68 AMP 2.40964
52 4CC6 L5Y 2.51572
53 1QKQ MAN 2.58621
54 5L2R MLA 2.58621
55 1M0W ANP 2.58621
56 2IO8 ADP 2.58621
57 3T1A 5MA 2.58621
58 1IIU RTL 2.58621
59 3X0V FAD 2.58621
60 3VOT ADP 2.58824
61 4OCV ANP 2.63852
62 4P25 FUC GAL NAG FUC 2.64901
63 5J75 6GQ 2.65152
64 4V36 LYN 2.68657
65 4WUJ FMN 2.72109
66 5MRH Q9Z 2.80172
67 1GSA ADP 2.8481
68 4GK9 MAN BMA MAN MAN MAN 2.86738
69 2OS2 OGA 2.88714
70 2YBP 2HG 2.88714
71 1V1A KDG 2.91262
72 5V1B 8UY 2.91667
73 4LI4 AMP 2.94118
74 5HV7 RBL 2.98165
75 1SLT NDG GAL 2.98507
76 3ZXE PGZ 3.00752
77 2VQD AP2 3.01724
78 2Z9I GLY ALA THR VAL 3.08642
79 1DFO FFO 3.11751
80 2P5B OGA 3.125
81 2Q8E OGA 3.125
82 1GVF PGH 3.14685
83 5GLT BGC GAL NAG GAL 3.16901
84 5DZT AMP 3.23276
85 2PUL ACP 3.27456
86 5HCA BGC 3.28467
87 3BU1 HSM 3.37838
88 1W2D ADP 3.39623
89 5M0T AKG 3.40136
90 1F52 ADP 3.4188
91 2XN5 FUN 3.42857
92 3BP1 GUN 3.44828
93 4ARE FLC 3.44828
94 5X7Q GLC GLC GLC GLC GLC 3.44828
95 4EZD SEY 3.44828
96 3PN1 IVH 3.45912
97 4WVW SLT 3.47222
98 3K5I ADP 3.47395
99 5T96 79J 3.50877
100 5C5T AKG 3.50877
101 3CBC DBS 3.53535
102 5YK1 ANP 3.53982
103 2QK4 ATP 3.53982
104 4YNM SAM 3.53982
105 4R78 AMP 3.55987
106 4RDL FUC GAL NDG FUC 3.57143
107 5GZ9 ANP 3.60656
108 6A63 LAT 3.62319
109 1CKM GTP 3.63636
110 1CKN GTP 3.63636
111 4MJ0 SIA SIA 3.63636
112 2CFI ZZZ 3.64742
113 5VZ0 ADP 3.66379
114 4PU5 ANP 3.66379
115 4OKD GLC GLC GLC 3.66379
116 3AKK ADP 3.69231
117 1W6P NDG GAL 3.73134
118 1F9V ADP 3.7464
119 2D6M LBT 3.77358
120 5C03 AGS 3.80117
121 1OGX EQU 3.81679
122 6EZ6 C5Z 3.87931
123 5AE9 OKO 3.87931
124 3WG3 A2G GAL NAG FUC 3.93258
125 2DTJ THR 3.93258
126 3AB4 THR 3.93258
127 5OLK DTP 3.95349
128 6BXO SAH 3.97554
129 2QGI UDP 4.03226
130 1Y7P RIP 4.03587
131 4DFU QUE 4.03727
132 5W1E PHB 4.09483
133 5W10 CMP 4.10256
134 3SJK LYS PRO VAL LEU ARG THR ALA 4.21053
135 3TII ANP 4.21053
136 4BG4 ADP 4.21348
137 3FSY SCA 4.21687
138 5G48 1FL 4.27807
139 1XL8 152 4.31034
140 1WW5 SGA BGC 4.375
141 4OUC 5ID 4.48179
142 6G34 5ID 4.48179
143 3ETH ATP 4.50704
144 1MDC PLM 4.54545
145 3E3U NVC 4.56853
146 6CGD AKN 4.59016
147 6CGD GNP 4.59016
148 2R0D 4IP 4.61095
149 2GQR ADP 4.64135
150 5DMZ ADP 4.65753
151 2IF8 ADP 4.6832
152 5ML3 DL3 4.69799
153 3PAK MAN 4.72973
154 5IM3 DTP 4.74138
155 3QXV MTX 4.7619
156 4XZ3 ACP 4.78261
157 4XYM A12 4.78261
158 1XK5 TPG 4.90196
159 3KFF XBT 4.93827
160 3KFF ZBT 4.93827
161 4O1P ANP 4.9569
162 5MW8 ATP 4.9569
163 5ZCT ANP 4.9569
164 5UQD AKG 4.9569
165 1Q19 SSC 4.9569
166 1YFS ALA 4.9569
167 1Z6K OAA 4.9569
168 3VPD ANP 4.98221
169 1CBK ROI 5
170 3I0O ADP 5.01475
171 3L8H FX1 5.02793
172 3RE4 TO1 5.03876
173 5H9P TD2 5.06329
174 4U98 ACP 5.06608
175 5CKW ANP 5.09978
176 4K37 SAM 5.13514
177 4K38 SAM 5.13514
178 4K39 SAM 5.13514
179 3C8F MT2 5.17241
180 6GNO XDI 5.18518
181 1ZB6 GST 5.21173
182 3OYW TDG 5.22388
183 4YLZ LAT NAG GAL 5.22876
184 4CYI ATP 5.25114
185 3HAV ATP 5.35117
186 5VLQ ANP 5.38793
187 5F7U GLC GLC 5.38793
188 3WV6 GAL BGC 5.40541
189 3DOO SKM 5.41516
190 2ZL7 FUC GAL NGA 5.42373
191 1E4E ADP 5.53936
192 2AGC DAO 5.55556
193 3ORQ ADP 5.57029
194 6BSX E7S 5.61798
195 3DNT ATP 5.68182
196 2WCV FUC 5.71429
197 1BCJ NGA 5.84416
198 5C1P ADP 5.88235
199 1LSH PLD 5.95611
200 2VQ5 HBA 5.97015
201 1A78 TDG 5.97015
202 4WOV 3SM 5.99369
203 3VPC ADP 6.02837
204 4TVD BGC 6.03448
205 1VRP ADP 6.03675
206 2YMZ LAT 6.15385
207 4LH7 1X8 6.19195
208 4NFE BEN 6.32911
209 5VNF VAL THR SER VAL VAL 6.36943
210 6BFN DL1 6.43275
211 2BKK ADP 6.43939
212 4K55 H6P 6.45161
213 3TM0 ANP 6.46388
214 3TM0 B31 6.46388
215 6M7X JD7 6.46552
216 3B6R CRN 6.56168
217 5USZ SKE 6.57439
218 3KIF GDL 6.60377
219 4X8N GLU ARG GLU SEP GLU PHE ASP ILE GLU ASP 6.62983
220 4FE2 ADP 6.66667
221 5TDF ADP 6.72854
222 4GYI ADP 6.80101
223 4OAV ACP 6.89655
224 4JGP PYR 6.91244
225 2CBO TH2 6.95652
226 5KBF CMP 6.97674
227 5T7I LAT NAG GAL 7.09677
228 4YVN EBS 7.11207
229 5A5W GUO 7.11462
230 2V58 LZJ 7.12695
231 5C4L 4XR 7.16511
232 5C4L SIS 7.16511
233 4KU7 PCG 7.18954
234 5ACM MBT 7.20721
235 4RD0 GDP 7.22892
236 1EWF PC1 7.23684
237 3HNA SAH 7.31707
238 4LIT AKG 7.37101
239 4UMX VVS 7.52941
240 1SU2 ATP 7.54717
241 2GQS ADP 7.59494
242 3X01 AMP 7.63359
243 5D9G GLU ASN LEU TYR PHE GLN 7.72358
244 3OF1 CMP 7.72358
245 1IA9 ANP 7.85714
246 5EZU MYR 7.86517
247 4AZW ATP 7.97414
248 4IX4 ADP 8
249 1TZD ADP 8
250 3TDV GDP 8.16993
251 4QBK 3NZ 8.24742
252 1Y60 H4M 8.28402
253 6DW2 HD4 8.43882
254 4JLS 3ZE 8.55263
255 4X3R 686 8.62069
256 4XH0 ADP 8.68486
257 2GOO NDG 8.77193
258 3BRN SRO 8.9172
259 5M06 ADP 9.05797
260 2PTM CMP 9.09091
261 5KJW 53C 9.13349
262 1OBD ATP 9.15033
263 5TWJ SAM 9.25926
264 1ULE GLA GAL NAG 9.33333
265 3WW2 SF9 9.375
266 4G17 0VN 9.39394
267 3NV3 GAL NAG MAN 9.42029
268 3WUD GLC GAL 9.55882
269 5KEW 6SB 9.57447
270 6EWZ APC 9.70464
271 1NU4 MLA 10.3093
272 6FA4 D1W 10.4046
273 4ZS4 ATP 10.4235
274 5OO5 UUA 10.4839
275 2Y7P SAL 10.5505
276 3M3E GAL A2G NPO 10.559
277 1VHZ APR 10.6061
278 3ZO7 K6H 10.6383
279 4WW7 AMP 10.6952
280 3VPB ADP 10.7143
281 4Y24 TD2 11.039
282 1J3R 6PG 11.0526
283 2GC0 PAN 11.1702
284 3SAO DBH 11.25
285 1ZTH ADP 11.6279
286 1ZP9 ATP 11.6279
287 3PDT ADP 11.6364
288 6E2B PT7 11.8421
289 6AC9 ANP 11.8919
290 1FWV SGA MAG FUC 11.9403
291 4Q5H ANP 12.069
292 3I8T LBT 12.1951
293 3VHE 42Q 12.2563
294 2XG5 EC5 12.3853
295 2XG5 EC2 12.3853
296 1TQP ATP 12.4113
297 2QX0 PH2 12.5786
298 4HZ0 1AV 12.6761
299 2FUE M1P 12.9771
300 5WL1 D3D 13.1313
301 5WL1 CUY 13.1313
302 1FHX 4IP 13.1783
303 2FB3 MET 13.2353
304 2FB3 5AD 13.2353
305 3RGA LSB 13.4276
306 4RYV ZEA 13.5484
307 5W3X ACO 13.75
308 5MST FUM 13.7931
309 3Q60 ATP 14.2857
310 2X2M X2M 14.3312
311 4I94 ANP 14.3333
312 5H9Q TD2 14.8387
313 5K2M ADP 15.0943
314 1M6P M6P 15.1316
315 5VX9 FUC GAL NAG GAL BGC 15.528
316 1JBU BEN 15.873
317 5WNL STU 16.0819
318 3PVW QRX 16.2162
319 1I7M PUT 16.4179
320 3GNI ATP 17.4807
321 1VJY 460 18.1518
322 4FL3 ANP 18.319
323 1UW1 ADP 18.75
324 4NPT 017 19.1919
325 4ITH RCM 19.7279
326 6GZD LCI 20.0535
327 4LRJ ANP 20.7101
328 3VRY B43 20.9251
329 4EUU BX7 21.0031
330 4PNI KQQ 21.0339
331 4Y93 746 21.0762
332 2PZI AXX 21.3362
333 4WNK 453 21.5517
334 4Y85 499 21.988
335 1GT4 UNA 22.0126
336 5VC5 96M 22.4914
337 5T8O 76Z 22.9226
338 5OKT 9XK 23.2484
339 2H8H H8H 23.2759
340 4L9I 8PR 23.4127
341 1NBU PH2 23.5294
342 5QIN J2V 23.7342
343 3C1X CKK 23.8606
344 1Y57 MPZ 23.8938
345 4DC2 ADE 23.9899
346 4UAL 3FV 24.105
347 3V8S 0HD 24.1463
348 4OTH DRN 24.3402
349 4P5Z Q7M 24.6537
350 4Y0X ADP 24.8
351 4BTK DTQ 24.9258
352 5U6C 7YS 25.0794
353 6ES0 BW8 25.2366
354 2CSN CKI 25.2525
355 4WB7 ATP 25.4321
356 3PP0 03Q 25.4438
357 4CLI 5P8 25.6881
358 5TA6 79D 25.6983
359 6GWR FEW 25.7143
360 4ASE AV9 25.779
361 4OH4 ANP 25.8258
362 4IDT T28 25.8427
363 2OO8 RAJ 25.8675
364 5LPZ ADP 25.9036
365 5JFS 6K0 25.974
366 3UIM ANP 26.0736
367 2F2U M77 26.1194
368 6C0T EE4 26.2248
369 4E93 GUI 26.2599
370 4NFN 2KC 26.5372
371 1OPK P16 26.9397
372 2R5T ANP 27.0777
373 5LI9 ACP 27.1429
374 4F9C 0SX 27.1468
375 3KRL KRL 27.1642
376 1U59 STU 27.1777
377 5W4W 9WG 27.1903
378 4KBA 1QM 27.1903
379 5UKL SIX 27.4194
380 3FC2 IBI 27.4627
381 3TXO 07U 27.4788
382 4UXL 5P8 27.6398
383 5HCY 60D 27.7946
384 4FF8 14S 27.8638
385 5EOB 5QQ 28.2132
386 4K33 ACP 28.3077
387 2PVF ACP 28.4431
388 3H9R TAK 28.4848
389 3GQI ACP 28.5276
390 3H0L ADP 28.7234
391 1U5R ATP 28.7356
392 5NLD LBT 28.777
393 3TKI S25 28.7926
394 4AG8 AXI 28.7975
395 5LI1 ANP 28.8136
396 2HY0 306 28.882
397 5LPB ADP 29.0541
398 2QCS ANP 29.1429
399 3FHI ANP 29.1429
400 4U44 3D9 29.2169
401 6BXI ANP 29.4294
402 4WB6 ATP 29.7143
403 3IGO ANP 29.7414
404 3HZT J60 29.7414
405 4X7Q 3YR 29.8077
406 5HVJ ANP 29.8413
407 4U0I 0LI 29.8413
408 5UR1 YY9 29.9035
409 4QMN DB8 30
410 3RI1 3RH 30.0319
411 3KMW ATP 30.2326
412 4BHN BH9 30.2395
413 4YMJ 4EJ 30.2632
414 4YZN 4K5 30.3136
415 3HMO STU 30.4094
416 3DLS ADP 30.4478
417 5JGA 6KC 30.4762
418 3LXN MI1 30.5031
419 3GGF GVD 30.5648
420 5DRB 5FJ 30.5842
421 5AX9 4KT 30.8442
422 4Y8D 49J 30.8824
423 3CY2 MB9 30.8917
424 6GIN IR2 30.897
425 1BYG STU 30.9353
426 6FYL 3NG 31.1295
427 5JKG 6LF 31.1897
428 3PLS ANP 31.2081
429 3NW7 LGV 31.2704
430 4E1Z 0MX 31.2715
431 6GQM F8H 31.4024
432 4GJ3 0XP 31.457
433 2RIO ADP 31.5668
434 4AT3 LTI 31.7726
435 5DBX ANP 32.0122
436 1K3A ACP 32.107
437 3LXK MI1 32.1101
438 5WO4 B7V 32.1192
439 4USF 6UI 32.2368
440 6CQF F97 32.3232
441 5VCV 1N1 32.4759
442 5Y86 HRM 32.5431
443 2UYN 2KT 32.5581
444 4YZC STU 32.5926
445 3C0G 3AM 32.7635
446 2XVD AS6 32.7815
447 3SXS PP2 32.8358
448 4M69 ANP 32.8622
449 5KO1 6UY 32.8622
450 3EKK GS2 32.899
451 5N87 N66 32.9073
452 3BU5 ATP 33.0065
453 1XJD STU 33.0435
454 3IDB ANP 33.1429
455 1RE8 BD2 33.1429
456 4JR7 GNP 33.1551
457 4ONA UW1 33.1897
458 3ORK AGS 33.4405
459 5MJA 7O3 33.4426
460 5Y80 IRE 33.5463
461 6C7Y ADP 33.9161
462 6E2O S0L 34.2373
463 2GU8 796 34.4214
464 4L3L 5FI 34.5395
465 4A4X JUP 34.767
466 2Z7R STU 34.891
467 5FBN 5WF 35.0554
468 4WNP 3RJ 35.1916
469 2HK5 1BM 35.5556
470 1PHK ATP 35.5705
471 1ZY5 ANP 35.6436
472 4N70 2HX 35.6707
473 3ALN ANP 35.7798
474 5CEO 50D 36
475 2YAB AMP 36.0111
476 4G31 0WH 36.1204
477 5TO8 7FM 36.1702
478 2A19 ANP 36.2676
479 5ZTN CUR 36.3636
480 6F3G CJN 36.6102
481 2QLU ADE 36.6242
482 4NW6 2NS 36.8421
483 3DAK ANP 36.8966
484 2WU6 DKI 37.0079
485 1JPA ANP 37.1795
486 2OFV 242 37.1841
487 5EH0 5NW 37.2093
488 2J7T 274 37.4172
489 3MVH WFE 37.4269
490 5OMY 9YE 37.5959
491 5HES 032 37.785
492 5UIU 8CG 38.0805
493 2JLD AG1 38.0952
494 3G5D 1N1 38.1119
495 3BZ3 YAM 38.7681
496 4CRL C1I 38.9163
497 2WQN ADP 39.3548
498 3M2W L8I 39.4649
499 5DH3 5BS 39.6825
500 3E8N VRA 39.8827
501 3E8N ATP 39.8827
502 2WEL K88 40.0612
503 5UPK ANP 40.1734
504 2Y6O 1N1 40.2062
505 5NKB 8ZT 40.5229
506 4EWH T77 40.7273
507 5MY8 RXZ 40.7311
508 5H2U 1N1 40.824
509 3KN5 ANP 40.9231
510 2JDR L20 40.9357
511 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 40.9357
512 4CSV STI 41.0909
513 3SRV S19 41.1552
514 5LVP ATP 41.1576
515 6CZ3 FLJ 41.2879
516 4NM5 ADP 41.6446
517 3FHR P4O 41.6667
518 4F4P 0SB 41.7582
519 4BFM ANP 41.9162
520 3ZRM ZRM 42.0485
521 4C2V YJA 42.1053
522 4RFM 3P6 42.1053
523 5IH9 6BF 42.3881
524 2PVN P63 42.6136
525 3SLS ANP 42.7632
526 3RWP ABQ 42.7653
527 4FG8 ATP 42.8571
528 4C2W ANP 43.0108
529 1IR3 ANP 43.1373
530 2V7O DRN 43.1548
531 6A1G 9OL 43.3333
532 3AQV TAK 43.4783
533 2VN9 GVD 43.5216
534 3PE2 E1B 43.6202
535 1Q8Y ADP 43.6997
536 1Q8Y ADE 43.6997
537 2VZ6 FEF 43.77
538 5EFQ ADP 44.3804
539 2F57 23D 44.4795
540 3F7Z 34O 44.5714
541 4I6H 1C8 44.8052
542 2YAK OSV 44.9123
543 5X8I SQZ 45.0867
544 5YF9 NIO 45.1327
545 1O9U ADZ 45.1429
546 4IJP 1EH 45.5307
547 5EYK 5U5 46.0145
548 4TWP AXI 46.1255
549 6G33 5ID 46.3127
550 4KS7 X4Z 46.5753
551 6FYV 3NG 46.5875
552 5DEY 59T 46.8013
553 5L8L ADP 47.0175
554 5G1X ADP 47.0175
555 5LXM ADP 47.3498
556 5ODT ADP 47.3498
557 6CMJ F6J 47.352
558 5XVG 8FX 47.4403
559 2XK9 XK9 47.5155
560 4NST ADP 47.5783
561 2WEI VGG 47.7352
562 4CQE CQE 47.8417
563 4XV1 904 47.9452
564 5A6N U7E 48.4099
565 3GC0 AMP 48.6322
566 2ZV2 609 48.6577
567 5EW9 5VC 49.0775
568 3E5A VX6 50
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