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Receptor
PDB id Resolution Class Description Source Keywords
4A6D 2.4 Å EC: 2.1.1.4 CRYSTAL STRUCTURE OF HUMAN N-ACETYLSEROTONIN METHYLTRANSFERASE (ASMT) IN COMPLEX WITH SAM HOMO SAPIENS TRANSFERASE MELATONIN CIRCADIAN CLOCK
Ref.: CRYSTAL STRUCTURE AND FUNCTIONAL MAPPING OF HUMAN A LAST ENZYME OF THE MELATONIN SYNTHESIS PATHWAY. J.PINEAL RES. V. 54 46 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:1355;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SAM A:1350;
Valid;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
SO4 A:1351;
A:1352;
A:1353;
A:1354;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
ZN A:1348;
A:1349;
Part of Protein;
Part of Protein;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4A6D 2.4 Å EC: 2.1.1.4 CRYSTAL STRUCTURE OF HUMAN N-ACETYLSEROTONIN METHYLTRANSFERASE (ASMT) IN COMPLEX WITH SAM HOMO SAPIENS TRANSFERASE MELATONIN CIRCADIAN CLOCK
Ref.: CRYSTAL STRUCTURE AND FUNCTIONAL MAPPING OF HUMAN A LAST ENZYME OF THE MELATONIN SYNTHESIS PATHWAY. J.PINEAL RES. V. 54 46 2013
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4A6D - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4A6D - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4A6D - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4A6D; Ligand: SAM; Similar sites found with APoc: 566
This union binding pocket(no: 1) in the query (biounit: 4a6d.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 5Y02 HBX None
2 5Y02 MXN None
3 3H2B SAH 0.985222
4 3A25 SAM 0.996678
5 6GAR FAD 1.43266
6 6EQS BV8 1.45455
7 6CI9 NAP 1.5444
8 1GY8 NAD 1.69972
9 4RPL FAD 1.69972
10 4RPL 3UC 1.69972
11 5E70 RCD 1.69972
12 1YBH FAD 1.69972
13 3WMX NAD 1.69972
14 4CNK FAD 1.69972
15 1SB8 UD2 1.70455
16 1SB8 NAD 1.70455
17 5BW4 SAM 1.87266
18 5F7J ADE 1.875
19 2UYQ SAM 1.93548
20 5EJ2 NAD 1.94805
21 1YXM ADE 1.9802
22 2EG5 SAH 1.983
23 5HJM MTA 1.983
24 5XNC MTA 1.983
25 1WVG APR 1.983
26 4MO2 FDA 1.983
27 4MO2 FAD 1.983
28 3X01 AMP 1.983
29 3V1U NAD 1.983
30 1E1M NAP 1.983
31 1E1M FAD 1.983
32 1Z3C SA8 2.01342
33 2VDV SAM 2.03252
34 1ZQ9 SAM 2.10526
35 3VPD CIT 2.13523
36 5THQ NDP 2.20588
37 3A4V NAD 2.2082
38 3A4V PYR 2.2082
39 4G5H UD7 2.26629
40 4G5H NAP 2.26629
41 1BZL FAD 2.26629
42 1BZL GCG 2.26629
43 6BWL NAD 2.26629
44 4UCI SAM 2.26629
45 1TUU AMP 2.26629
46 2O07 SPD 2.30263
47 2O07 MTA 2.30263
48 2WPB ZZI 2.30263
49 2AE2 NAP 2.30769
50 2AE2 PTO 2.30769
51 4O8A 2OP 2.32897
52 4YAC NAI 2.3569
53 4FN4 NAD 2.3622
54 2EWM NAD 2.40964
55 2PZM UDP 2.42424
56 2PZM NAD 2.42424
57 3CH6 311 2.44755
58 3CH6 NAP 2.44755
59 3GU3 SAH 2.46479
60 5YJI SAH 2.46479
61 5YJI 8WO 2.46479
62 1UAY ADN 2.47934
63 1KEW NAD 2.49307
64 1GZ6 NAI 2.50784
65 2RH4 EMO 2.52708
66 2WA2 SAM 2.53623
67 2EFJ SAH 2.54958
68 3TLJ SAH 2.54958
69 5JAQ NAI 2.54958
70 4EUE NAI 2.54958
71 4C4A SAH 2.54958
72 1EDO NAP 2.54958
73 3C6K SPD 2.54958
74 3X0D SAH 2.54958
75 3C6K MTA 2.54958
76 5JCM NAD 2.54958
77 5JCM FAD 2.54958
78 5JCM ISD 2.54958
79 1FEC FAD 2.54958
80 1ZBQ NAD 2.54958
81 4ONQ SFG 2.54958
82 2WSB NAD 2.54958
83 6AM8 TRP 2.54958
84 2C31 TZD 2.54958
85 2C31 ADP 2.54958
86 1COY AND 2.54958
87 1COY FAD 2.54958
88 3KLJ FAD 2.54958
89 3VC1 SAH 2.5641
90 3VC1 GST 2.5641
91 3A27 SAM 2.57353
92 1OC2 NAD 2.58621
93 1OC2 TDX 2.58621
94 1VL8 NAP 2.62172
95 2DTX BMA 2.65152
96 5AEW BNL 2.65957
97 1XHL NDP 2.6936
98 1JQ3 AAT 2.7027
99 2PT9 2MH 2.80374
100 2PT9 S4M 2.80374
101 5YRF GLC GLC 2.8169
102 2FK8 SAM 2.83019
103 4KRG SAH 2.83286
104 2JHP SAH 2.83286
105 5FWA J7C 2.83286
106 5BVA FAD 2.83286
107 6ECU SAH 2.8481
108 1EFV FAD 2.85714
109 1EFV AMP 2.85714
110 6ARJ BW4 2.86533
111 6ARJ SAH 2.86533
112 5DX8 SFG 2.86533
113 5DX1 SFG 2.86533
114 5DXA SFG 2.86533
115 5DWQ SFG 2.86533
116 5DX0 SFG 2.86533
117 1AE1 NAP 2.9304
118 2P41 SAH 2.95082
119 5FUB SAH 2.96736
120 5A3B APR 2.9703
121 1ZX5 LFR 3
122 4NEC SAH 3.0303
123 1XSE NDP 3.05085
124 3GRU AMP 3.05085
125 3O03 NAP 3.09278
126 4TQG NDP 3.09598
127 5N5D SAM 3.09735
128 4KRI SAH 3.11615
129 4DCM SAM 3.11615
130 2V6G NAP 3.11615
131 2XVF FAD 3.11615
132 1PVN MZP 3.11615
133 5WUW NAP 3.13589
134 1NV8 SAM 3.16901
135 5GWX SAR 3.16901
136 5GWX SAM 3.16901
137 1NV8 MEQ 3.16901
138 4CNO 9PY 3.1746
139 2I7C AAT 3.18021
140 1ZK4 NAP 3.18725
141 1ZK4 AC0 3.18725
142 5BSZ SAH 3.2
143 2JAP NDP 3.23887
144 3EVF SAH 3.2491
145 3EVF GTA 3.2491
146 3NNT DQA 3.26087
147 4K26 SFF 3.26087
148 3EVG SAH 3.27273
149 3A4T SFG 3.28467
150 4YMH SAH 3.33333
151 5K0A FAD 3.33333
152 5DM1 5D7 3.37079
153 5DM1 SAH 3.37079
154 5CUQ NSC 3.37079
155 1H5Q NAP 3.39623
156 5YF1 8V0 3.39943
157 5YF1 SFG 3.39943
158 5T67 JHZ 3.39943
159 5T67 SAH 3.39943
160 1UWK NAD 3.39943
161 1UWK URO 3.39943
162 3L9W AMP 3.39943
163 3L9W GSH 3.39943
164 2V3V MGD 3.39943
165 6DEN G8A 3.39943
166 6DEN TP9 3.39943
167 6DEN FAD 3.39943
168 5KMS FAD 3.39943
169 6GKV SAH 3.4188
170 4BLW AMP 3.46021
171 4BLW SAH 3.46021
172 1L1E SAH 3.48432
173 2ZWI C5P 3.48525
174 3OID NDP 3.48837
175 4NBW NAD 3.50195
176 2Q0L FAD 3.53698
177 5ZW3 SAH 3.55556
178 6GFK SAH 3.58566
179 5KVA SAM 3.59712
180 1BXK NAD 3.66197
181 2XVE FAD 3.66379
182 5Z75 NAD 3.66972
183 6C8R SAH 3.68272
184 5X62 SAH 3.68272
185 4DMG SAM 3.68272
186 5DNK SAH 3.68272
187 4N49 SAM 3.68272
188 2EJU SAH 3.68272
189 6D6Y SAH 3.68272
190 6C8R EQV 3.68272
191 3EYA FAD 3.68272
192 1V5F FAD 3.68272
193 1V5F TPP 3.68272
194 5VN0 FAD 3.68272
195 5VN0 NAI 3.68272
196 2PXX SAH 3.72093
197 6ECT SAM 3.73832
198 4RVG TYD 3.75587
199 4RVG SAM 3.75587
200 1G55 SAH 3.79009
201 5JGL SAM 3.80623
202 1ZEM NAD 3.81679
203 2NU8 COA 3.81944
204 1U7T TDT 3.83142
205 1TPY SAH 3.83275
206 5E9W SAH 3.84615
207 5W7M SAH 3.84615
208 2YX1 SFG 3.86905
209 3EGI ADP 3.8835
210 1EJ0 SAM 3.88889
211 1GEG NAD 3.90625
212 1XTP SAI 3.93701
213 5DEQ ARA 3.94737
214 5KOK SAH 3.96601
215 3VSE SAH 3.96601
216 5KOK R9T 3.96601
217 5KOK S9T 3.96601
218 1X87 NAD 3.96601
219 1T9D P25 3.96601
220 1T9D PYD 3.96601
221 1T9D 1MM 3.96601
222 1DL5 SAH 3.96601
223 3S1S SAH 3.96601
224 5HSA FAS 3.96601
225 5WKC FAD 3.96601
226 1T9D FAD 3.96601
227 3HQ9 OXL 4.05797
228 2GN4 NDP 4.06977
229 2GN4 UD1 4.06977
230 4M38 SAH 4.08163
231 4M37 SAH 4.08163
232 1QAN SAH 4.09836
233 1UDB UFG 4.14201
234 1UDB NAD 4.14201
235 5W7K SAH 4.16667
236 4ZNO SUC 4.1791
237 1KPG SAH 4.18118
238 1KPH SAH 4.18118
239 2WPF FAD 4.24242
240 2WPF WPF 4.24242
241 6DUB SAH 4.24929
242 1SQF SAM 4.24929
243 1RLZ NAD 4.24929
244 4M52 FAD 4.24929
245 5UAO FAD 4.24929
246 3GF4 UPG 4.24929
247 3GF4 FAD 4.24929
248 4LHD GLY 4.24929
249 1ORR NAD 4.32277
250 3PA8 621 4.33071
251 5FA8 SAM 4.34783
252 1WY7 SAH 4.34783
253 5O42 NAD 4.37956
254 5O42 BGC 4.37956
255 5O42 9JW 4.37956
256 1BC5 SAH 4.46097
257 5F2K OCA 4.53258
258 5F2K SAH 4.53258
259 2ZWA SAH 4.53258
260 1G60 SAM 4.53258
261 1V59 NAD 4.53258
262 2ZXI FAD 4.53258
263 1RM0 D6P 4.53258
264 1RM0 NAI 4.53258
265 1V59 FAD 4.53258
266 1H0H MGD 4.53258
267 5JBX MLI 4.5977
268 3LCV SAM 4.62633
269 1Q0S SAH 4.6332
270 2C49 ADN 4.63576
271 3ELW SAM 4.66667
272 3ELW GP3 4.66667
273 1E6E FAD 4.6875
274 2ZIF SAM 4.7138
275 1RJW ETF 4.71976
276 3FRH SAH 4.74308
277 2Q46 NAP 4.74308
278 1JQD HSM 4.79452
279 1JQD SAH 4.79452
280 3FUU ADN 4.79705
281 5FEU NAP 4.811
282 1I2B NAD 4.81586
283 1I2B USQ 4.81586
284 1I2B UPG 4.81586
285 4FZV SAM 4.81586
286 3LU1 NAD 4.81586
287 3ICT FAD 4.81586
288 3ICS FAD 4.81586
289 6EL3 NAP 4.81586
290 3ICR FAD 4.81586
291 2GDZ NAD 4.81586
292 5ULP KB1 4.85075
293 3P2E SAH 4.88889
294 5Z3I ADE 4.90566
295 5GT9 NAP 4.94297
296 3LKZ SFG 4.98442
297 3FZG SAM 5
298 1LSS NAD 5
299 1R6D NAD 5.04451
300 1R6D DAU 5.04451
301 1BDB NAD 5.05415
302 1RJD SAM 5.08982
303 3MB5 SAM 5.09804
304 5WP5 SAH 5.09915
305 5JJR SAH 5.09915
306 5BJX UDP 5.09915
307 5BJX NAD 5.09915
308 5N0J FAD 5.09915
309 5MLR NAP 5.09915
310 5MLR GRQ 5.09915
311 3SSO SAH 5.09915
312 1EU1 MGD 5.09915
313 2IHK CSF 5.09915
314 1RSG FAD 5.09915
315 6BQ6 TER 5.13595
316 2AOT SAH 5.13699
317 5Y1G AKB 5.18293
318 5Y1G NAD 5.18293
319 2PX8 SAH 5.20446
320 5DLY 5D7 5.26316
321 5DLY SAH 5.26316
322 2JAH NDP 5.26316
323 3ZV6 4HB 5.33808
324 3ZV6 NAD 5.33808
325 3NDJ JHZ 5.38244
326 3NDJ SAH 5.38244
327 3DMH GMP 5.38244
328 5ERG SAM 5.38244
329 1I8T FAD 5.38244
330 3DMH SAM 5.38244
331 2BGM NAJ 5.39568
332 5FFF 5XC 5.44747
333 5FFF NAP 5.44747
334 3MQ2 SAH 5.50459
335 1XCL SAH 5.53191
336 3SJ7 NDP 5.55556
337 2HMT NAI 5.55556
338 4PIO AVI 5.57276
339 4PIO SAH 5.57276
340 2VT3 ATP 5.5814
341 4NBU NAI 5.6
342 2IV2 MGD 5.66572
343 3HDY FDA 5.66572
344 3HDY GDU 5.66572
345 3HDY FAD 5.66572
346 5U8U FAD 5.66572
347 1JG9 GLC 5.66572
348 2RAB FAD 5.66572
349 2RAB NAD 5.66572
350 3GCZ SAM 5.67376
351 6FDF SAH 5.68862
352 2BD0 NAP 5.7377
353 4CQM NAP 5.7377
354 3WDM ADN 5.74713
355 3TKA SAM 5.76369
356 1Y8Q ATP 5.78035
357 3HVJ 705 5.88235
358 5UFN SAH 5.88235
359 4HXY NDP 5.93607
360 4ITU 1HS 5.94796
361 4ITU NAI 5.94796
362 1F3L SAH 5.94901
363 2JJQ SAH 5.94901
364 4TQK NAG 5.94901
365 5WGR FAD 5.94901
366 6F97 FAD 5.94901
367 1NW5 SAM 5.95611
368 3LCC SAH 5.95745
369 4XUC SAM 5.9633
370 4XUC 43G 5.9633
371 1JNR FAD 6.06532
372 1I9G SAM 6.07143
373 1E3W NAD 6.13027
374 1E6W NAD 6.15385
375 3H8V ATP 6.16438
376 3EWP APR 6.21469
377 6F9Q NAD 6.23229
378 2OG2 MLI 6.23229
379 4YNU FAD 6.23229
380 4YNU LGC 6.23229
381 2BRY FAD 6.23229
382 4RF2 NAP 6.25
383 4GQB 0XU 6.51558
384 4X60 3XV 6.51558
385 4X60 SFG 6.51558
386 5FA5 MTA 6.51558
387 4AZW SAM 6.51558
388 4Z24 FAD 6.51558
389 3G5S FAD 6.51558
390 2Q28 ADP 6.51558
391 2VVL FAD 6.51558
392 1P1C SAH 6.53266
393 4YAG NAI 6.57439
394 4YUW 4JU 6.57895
395 4YUW S4M 6.57895
396 3A28 NAD 6.58915
397 1FUT 2GP 6.60377
398 6ECW SAH 6.66667
399 5K7U SAM 6.66667
400 5YJF SAH 6.69014
401 5YJF 8WO 6.69014
402 5NMX FAD 6.79887
403 5NMX NAP 6.79887
404 3LAD FAD 6.79887
405 5TWB FAD 6.79887
406 1NM5 NAP 6.79887
407 3NUG NAD 6.88259
408 3JWH SAH 6.91244
409 5E72 SAM 6.93642
410 5IL1 SAM 7.07547
411 5WP4 SAH 7.08215
412 4PNE SAH 7.08215
413 3PT9 SAH 7.08215
414 3U4C NDP 7.11744
415 4Y30 49L 7.12251
416 4Y30 SAH 7.12251
417 2CFC NAD 7.2
418 2A14 SAH 7.22433
419 3BGD SAH 7.30769
420 3BGD PM6 7.30769
421 5U19 SAH 7.33138
422 5U19 827 7.33138
423 4LWP SAH 7.33696
424 2PWY SAH 7.36434
425 4Y9D NAI 7.36544
426 5DF1 NAP 7.36544
427 5DF1 58X 7.36544
428 4CS9 AMP 7.40741
429 1R37 NAD 7.4928
430 3KIF GDL 7.54717
431 2OBF SAH 7.61246
432 2OBF F83 7.61246
433 1XKQ NDP 7.64873
434 3EF0 ALF 7.64873
435 1Z45 NAD 7.64873
436 2BZG SAH 7.75862
437 3DXY SAM 7.79817
438 2Q1W NAD 7.80781
439 3T7S SAM 7.83582
440 4ZA2 NAD 7.90514
441 5Z2L NDP 7.93201
442 3FPF TNA 8.05369
443 3FPF MTA 8.05369
444 4URF NAD 8.06452
445 5OJI NAP 8.07692
446 5OJI ISN 8.07692
447 4MDH NAD 8.08383
448 5MDH NAD 8.10811
449 4QTU SAM 8.17308
450 1G0N NDP 8.2153
451 1G0N PHH 8.2153
452 1TMO 2MD 8.2153
453 2YY7 NAD 8.33333
454 3G2O SAM 8.3612
455 3BXO SAM 8.3682
456 3G89 SAM 8.43373
457 2WET FAD 8.49858
458 4NTO 1PW 8.69565
459 3PFG SAM 8.78187
460 3PFG TLO 8.78187
461 1NJR XYL 8.78187
462 5XLX SAH 8.86525
463 2XYQ SAH 9.01639
464 2XVM SAH 9.04523
465 1RKX NAD 9.06516
466 1WG8 SAM 9.12281
467 1JA9 NDP 9.12409
468 4II2 ATP 9.20245
469 5OVK NDP 9.375
470 6B92 SAH 9.52381
471 3RKR NAP 9.54198
472 5MPT SAH 9.63173
473 2HQM FAD 9.63173
474 2HYQ MAN MAN 9.83607
475 2GUD MAN 9.83607
476 2GUC MAN 9.83607
477 2HYR BGC GLC 9.83607
478 2NU5 NAG 9.83607
479 2NUO BGC 9.83607
480 2GUD BMA 9.83607
481 3GDH SAH 9.95851
482 1N2X SAM 9.96678
483 4POO SAM 10
484 5LOG SAH 10.3004
485 5D9X GSH 10.4348
486 2V2V V12 10.7011
487 1O97 FAD 10.9375
488 1O97 AMP 10.9375
489 4ZRN NAD 11.0482
490 4ZRN UPG 11.0482
491 3ML1 MGD 11.1111
492 4EMJ FAD 11.215
493 5TQZ GLC 11.3333
494 3O7W SAM 11.5646
495 4GKV NAD 11.9048
496 1JG3 ADN 11.9149
497 4OBW SAM 12.0623
498 3QOX SAH 12.1813
499 1IY8 NAD 12.3596
500 3OU2 SAH 12.3853
501 5GM1 SAH 12.4579
502 5THY SAH 12.4646
503 5THZ SAH 12.4646
504 2F5Z FAD 12.5
505 5MW4 5JU 12.5749
506 3VYW SAM 12.6623
507 1R18 SAH 13.2159
508 2DPM SAM 13.3803
509 6B3A SAM 13.5977
510 5FTW SAH 13.6719
511 1U2Z SAH 14.4476
512 3QWI NAP 14.8148
513 3QWI CUE 14.8148
514 2ZFU SAH 14.8837
515 4DSG FAD 15.5807
516 4DSG UDP 15.5807
517 2HNK SAH 15.8996
518 3GEG NAD 16.5992
519 2NXE SAM 17.7165
520 2VPY MGD 18.1818
521 1PJS NAD 18.4136
522 1I1N SAH 18.5841
523 5MGZ SAH 18.6441
524 5E1M SAH 18.6722
525 5E1M PRO PRO LYS ARG ILE ALA 18.6722
526 5L95 AMP 18.75
527 1G8K MGD 18.797
528 1IM8 SAI 19.6721
529 4R6W PC 20.155
530 4R6W SAH 20.155
531 3Q87 SAM 20.5882
532 1FP2 HMO 20.7386
533 1FP2 SAH 20.7386
534 5M58 SAH 20.8696
535 4E70 N7I 21.2465
536 3I53 SAH 21.3855
537 5F8F SFG 21.813
538 5JE0 SAH 23.4818
539 5JE0 AZ8 23.4818
540 6F5Z SAH 23.8095
541 1L3I SAH 23.9583
542 4IWN GEK 24.0175
543 1VE3 SAM 24.2291
544 4M73 SAH 26.3456
545 4M73 M72 26.3456
546 5EEH SAH 27.1955
547 5EEH P9P 27.1955
548 3OFK SAH 27.7778
549 1XDS SAM 28.3286
550 1QZZ SAM 28.8952
551 4KIB SAH 28.8952
552 5E8J SAH 34.0909
553 5W7R SAH 35.694
554 5W7R 9Z7 35.694
555 3GWZ SAH 38.5269
556 3GXO SAH 38.5269
557 3LST SAH 39.3678
558 3P9C SAH 40.5099
559 1FP1 SAH 40.7932
560 1ZGA SAH 41.3598
561 6C5B SAH 41.9355
562 1KYZ SAH 42.2096
563 1KYZ FER 42.2096
564 5ICE 2H4 43.0595
565 5ICE SAH 43.0595
566 3TKY SAH 43.9093
Pocket No.: 2; Query (leader) PDB : 4A6D; Ligand: SAM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4a6d.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
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