Receptor
PDB id Resolution Class Description Source Keywords
4CD0 2.23 Å EC: 2.7.10.1 STRUCTURE OF L1196M MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE COMPLEX W ITH 2-(5-(6-AMINO-5-((R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2PH ENYL)ETHOXY)PYRIDIN-3-YL)-4-METHYLTHIAZOL-2-YL)PROPANE-1, ALK TYROSINE KINASE RECEPTOR HOMO SAPIENS
Ref.: THE DESIGN OF POTENT AND SELECTIVE INHIBITORS TO OV CLINICAL ALK MUTATIONS RESISTANT TO CRIZOTINIB. J.MED.CHEM. V. 57 1170 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AWJ A:1500;
Valid;
none;
Ki = 0.2 nM
472.536 C22 H25 F N6 O3 S Cc1c(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4CLI 2.05 Å EC: 2.7.10.1 STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL- OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2 ,5,11)BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE). HOMO SAPIENS TRANSFERASE INHIBITOR
Ref.: DISCOVERY OF (10R)-7-AMINO-12-FLUORO-2,10,16-TRIMET OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO H][2,5,11]BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRI 06463922), A MACROCYCLIC INHIBITOR OF ALK/ROS1 WITH CLINICAL BRAIN EXPOSURE AND BROAD SPECTRUM
Members (39)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 31 families.
1 5AAA Ki = 0.38 nM VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
2 4CLJ Ki = 0.1 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
3 4CMO Ki = 0.85 nM YPW C20 H20 F N5 O3 C[C@H](c1c....
4 5AA8 Ki = 8.6 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
5 3LCS - STU C28 H26 N4 O3 C[C@@]12[C....
6 4CCU - AWF C22 H23 F N6 O2 S Cc1c(sc(n1....
7 5IUH ic50 = 402 nM 34Y C30 H36 N8 O3 Cc1cc(ccc1....
8 2XB7 Ki = 0.65 nM GUI C30 H40 Cl N7 O3 S CC(C)S(=O)....
9 5J7H ic50 = 0.37 nM 6GY C29 H39 Cl N7 O2 P CN1CCN(CC1....
10 4CCB - OFG C19 H18 F N7 O Cc1c(c[nH]....
11 4CTC - J99 C23 H24 F N5 O2 C[C@@H]1c2....
12 4FOD ic50 = 0.0012 uM 0UV C33 H44 F N5 O3 CC(C)NC(=O....
13 4DCE ic50 = 0.174 uM 0JF C27 H33 N5 O4 Cc1ccc(cc1....
14 5AAC Ki = 1.3 nM VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
15 5IUI - 45Q C23 H28 N6 O Cc1cc(ccc1....
16 5IMX - CZ4 C27 H38 Cl N7 O3 S Cc1cc(c(cc....
17 4ANQ ic50 = 605 nM VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
18 4Z55 ic50 = 13 nM 4LO C30 H39 N7 O3 S Cc1cc(c(cc....
19 5A9U Ki = 0.08 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
20 4FOB ic50 = 0.005 uM 0US C30 H39 N5 O4 S C=CCNS(=O)....
21 5FTQ ic50 = 0.01 uM U4W C32 H36 F2 N6 O2 CN1CCN(CC1....
22 3AOX Kd = 2.4 nM EMH C30 H34 N4 O2 CCc1cc2c(c....
23 4CD0 Ki = 0.2 nM AWJ C22 H25 F N6 O3 S Cc1c(sc(n1....
24 5AA9 Ki = 6.4 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
25 3LCT - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
26 2XBA Ki = 23.68 nM 571 C25 H27 N6 O3 CN1CCN(CC1....
27 5IUG ic50 = 177 nM 729 C31 H38 N8 O3 Cc1cc(ccc1....
28 4MKC - 4MK C28 H36 Cl N5 O3 S Cc1cc(c(cc....
29 4CTB - KVC C23 H18 F N7 O2 C[C@@H]1c2....
30 5AAB Ki = 0.88 nM VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
31 2XP2 - VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
32 4CLI Ki < 0.07 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
33 4CMT Ki < 0.2 nM GWH C22 H22 F N5 O3 S C[C@H](c1c....
34 4FOC ic50 = 0.003 uM 0UU C28 H34 N4 O3 COC(=O)C1C....
35 4CNH Ki = 4 nM 3U9 C17 H18 F N5 O2 C[C@H](c1c....
36 4FNY ic50 = 0.256 uM I3K C24 H18 Cl N3 O4 COc1cc2c(c....
37 5KZ0 Ki = 22 nM 6YL C21 H24 F N5 O2 Cc1c(cn(n1....
38 4CMU Ki < 0.2 nM IV7 C21 H22 F N5 O2 Cc1c-2c(n(....
39 5FTO ic50 = 0.012 uM YMX C31 H34 F2 N6 O2 CN1CCN(CC1....
70% Homology Family (39)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 5AAA Ki = 0.38 nM VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
2 4CLJ Ki = 0.1 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
3 4CMO Ki = 0.85 nM YPW C20 H20 F N5 O3 C[C@H](c1c....
4 5AA8 Ki = 8.6 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
5 3LCS - STU C28 H26 N4 O3 C[C@@]12[C....
6 4CCU - AWF C22 H23 F N6 O2 S Cc1c(sc(n1....
7 5IUH ic50 = 402 nM 34Y C30 H36 N8 O3 Cc1cc(ccc1....
8 2XB7 Ki = 0.65 nM GUI C30 H40 Cl N7 O3 S CC(C)S(=O)....
9 5J7H ic50 = 0.37 nM 6GY C29 H39 Cl N7 O2 P CN1CCN(CC1....
10 4CCB - OFG C19 H18 F N7 O Cc1c(c[nH]....
11 4CTC - J99 C23 H24 F N5 O2 C[C@@H]1c2....
12 4FOD ic50 = 0.0012 uM 0UV C33 H44 F N5 O3 CC(C)NC(=O....
13 4DCE ic50 = 0.174 uM 0JF C27 H33 N5 O4 Cc1ccc(cc1....
14 5AAC Ki = 1.3 nM VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
15 5IUI - 45Q C23 H28 N6 O Cc1cc(ccc1....
16 5IMX - CZ4 C27 H38 Cl N7 O3 S Cc1cc(c(cc....
17 4ANQ ic50 = 605 nM VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
18 4Z55 ic50 = 13 nM 4LO C30 H39 N7 O3 S Cc1cc(c(cc....
19 5A9U Ki = 0.08 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
20 4FOB ic50 = 0.005 uM 0US C30 H39 N5 O4 S C=CCNS(=O)....
21 5FTQ ic50 = 0.01 uM U4W C32 H36 F2 N6 O2 CN1CCN(CC1....
22 3AOX Kd = 2.4 nM EMH C30 H34 N4 O2 CCc1cc2c(c....
23 4CD0 Ki = 0.2 nM AWJ C22 H25 F N6 O3 S Cc1c(sc(n1....
24 5AA9 Ki = 6.4 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
25 3LCT - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
26 2XBA Ki = 23.68 nM 571 C25 H27 N6 O3 CN1CCN(CC1....
27 5IUG ic50 = 177 nM 729 C31 H38 N8 O3 Cc1cc(ccc1....
28 4MKC - 4MK C28 H36 Cl N5 O3 S Cc1cc(c(cc....
29 4CTB - KVC C23 H18 F N7 O2 C[C@@H]1c2....
30 5AAB Ki = 0.88 nM VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
31 2XP2 - VGH C21 H22 Cl2 F N5 O C[C@H](c1c....
32 4CLI Ki < 0.07 nM 5P8 C21 H19 F N6 O2 C[C@@H]1c2....
33 4CMT Ki < 0.2 nM GWH C22 H22 F N5 O3 S C[C@H](c1c....
34 4FOC ic50 = 0.003 uM 0UU C28 H34 N4 O3 COC(=O)C1C....
35 4CNH Ki = 4 nM 3U9 C17 H18 F N5 O2 C[C@H](c1c....
36 4FNY ic50 = 0.256 uM I3K C24 H18 Cl N3 O4 COc1cc2c(c....
37 5KZ0 Ki = 22 nM 6YL C21 H24 F N5 O2 Cc1c(cn(n1....
38 4CMU Ki < 0.2 nM IV7 C21 H22 F N5 O2 Cc1c-2c(n(....
39 5FTO ic50 = 0.012 uM YMX C31 H34 F2 N6 O2 CN1CCN(CC1....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 7 families.
1 4CD0 Ki = 0.2 nM AWJ C22 H25 F N6 O3 S Cc1c(sc(n1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: AWJ; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 AWJ 1 1
2 GWH 0.522936 0.730337
3 AWF 0.522523 0.807692
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4CLI; Ligand: 5P8; Similar sites found: 355
This union binding pocket(no: 1) in the query (biounit: 4cli.bio1) has 42 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4CSD MFU 0.01383 0.44198 1.10294
2 2YFB SIN 0.04673 0.41059 1.16279
3 3AKK ADP 0.000485 0.48239 1.23077
4 5W2I ADP 0.01183 0.40567 1.55642
5 5W2I I3P 0.01183 0.40567 1.55642
6 2FCU AKG 0.04822 0.41151 1.59744
7 1OBD ATP 0.002009 0.47057 1.63399
8 4GYI ADP 0.0000667 0.546 1.83486
9 3WXL ADP 0.02794 0.42581 1.83486
10 1MUU SUC 0.04625 0.41902 1.83486
11 5TT6 ATP 0.008044 0.41878 1.83486
12 3V4S ATP 0.01861 0.40223 1.83486
13 3TDV GDP 0.0009272 0.47346 1.96078
14 3RL3 5GP 0.03147 0.406 2.02703
15 5D1R 56S 0.03592 0.40633 2.09205
16 2PUL ACP 0.00002388 0.55558 2.14067
17 4OCV ANP 0.002084 0.45267 2.14067
18 3TPV ADE 0.006237 0.4303 2.14067
19 3ORQ ADP 0.005549 0.42931 2.14067
20 3DNT ATP 0.004182 0.42539 2.14067
21 1ZGS XMM 0.03343 0.41786 2.14067
22 1OKE BOG 0.04334 0.40543 2.14067
23 4DFU QUE 0.01804 0.43395 2.17391
24 4CC6 L5Y 0.01091 0.44137 2.20126
25 3OF1 CMP 0.03458 0.41065 2.43902
26 2PVN P63 0.00000007137 0.60817 2.44648
27 4CYI ATP 0.00005335 0.52216 2.44648
28 3TII ANP 0.008281 0.44334 2.44648
29 3S6X SIA GAL BGC 0.03502 0.41242 2.46154
30 3VPB ADP 0.0003714 0.46746 2.48227
31 3VPC ADP 0.0007929 0.46428 2.48227
32 4J26 EST 0.04479 0.40134 2.5
33 1ZVW PRP 0.02134 0.40509 2.6455
34 4P25 FUC GAL NAG FUC 0.01657 0.41338 2.64901
35 2YRX AMP 0.01272 0.44285 2.66075
36 5FYR INS 0.03741 0.40662 2.68456
37 4AGQ P96 0.01556 0.40306 2.73973
38 4FE2 ADP 0.008933 0.43745 2.7451
39 4FE2 AIR 0.03699 0.4091 2.7451
40 1TQP ATP 0.00001856 0.52786 2.75229
41 2IO8 ADP 0.0002418 0.47931 2.75229
42 2VQD AP2 0.0005815 0.47443 2.75229
43 1EHI ADP 0.003634 0.44134 2.75229
44 4UWH JXM 0.006979 0.4389 2.75229
45 3VSV XYS 0.03047 0.42109 2.75229
46 5EK3 5PK 0.04086 0.41039 2.75229
47 5BRP PNG 0.04941 0.40861 2.75229
48 2Q7D ANP 0.008277 0.40712 2.75229
49 2Z49 AMG 0.0458 0.40116 2.75229
50 4ZTD ALA GLY ALA GLY ALA 0.03958 0.41435 2.7668
51 3AB4 THR 0.0471 0.40351 2.80899
52 1IA9 ANP 0.0001081 0.51297 2.85714
53 4R78 AMP 0.001125 0.4942 2.91262
54 1T36 ADP 0.003466 0.42027 3.0581
55 3JQ3 ADP 0.02844 0.41515 3.0581
56 5FPE 3TR 0.02829 0.41013 3.0581
57 1UH4 GLC GLC GLC GLC GLC GLC 0.03669 0.40343 3.0581
58 4LH7 1X8 0.002692 0.47968 3.09598
59 4D52 GIV 0.0295 0.42021 3.1746
60 4D52 GXL 0.03213 0.4155 3.1746
61 4D4U FUC NDG GAL FUC 0.04257 0.40804 3.1746
62 4XMF HSM 0.007229 0.4749 3.26087
63 4D00 SIA GAL NAG 0.03591 0.41345 3.27869
64 2R5V HHH 0.04728 0.40012 3.36134
65 3UDZ ADP 0.00005764 0.52578 3.36391
66 3TY5 ATP 0.007456 0.44572 3.36391
67 3TY5 ADP 0.01103 0.42893 3.36391
68 5X7Q GLC GLC 0.03543 0.41703 3.36391
69 2GQS ADP 0.001419 0.46892 3.37553
70 2GQR ADP 0.001475 0.4681 3.37553
71 2XZ9 PYR 0.03387 0.41871 3.39506
72 4MG9 27K 0.01956 0.43201 3.52941
73 1NE6 SP1 0.01459 0.41935 3.53357
74 5C1P ADP 0.01064 0.43355 3.59477
75 1KHT AMP 0.04651 0.40732 3.64583
76 2IF8 ADP 0.001646 0.49107 3.66972
77 5DZT AMP 0.001827 0.49022 3.66972
78 5MW8 ATP 0.0002665 0.48149 3.66972
79 4ANW O92 0.00005297 0.48045 3.66972
80 3ETH ATP 0.001772 0.4485 3.66972
81 4CFT H4B 0.03985 0.41778 3.66972
82 4CU1 H4B 0.04948 0.41184 3.66972
83 4DO1 ANN 0.04417 0.40825 3.66972
84 5JAX 6J7 0.01139 0.42465 3.7037
85 3M3E GAL A2G NPO 0.02605 0.42093 3.72671
86 3AI3 SOE 0.02701 0.42424 3.80228
87 5F90 GLA GAL 0.03471 0.40728 3.84615
88 1ZTH ADP 0.00002074 0.57912 3.87597
89 3RE4 TO1 0.00002217 0.57761 3.87597
90 1ZP9 ATP 0.00001703 0.5693 3.87597
91 4OUJ LBT 0.01975 0.42377 3.90879
92 4XYM A12 0.005716 0.43208 3.91304
93 5VZ0 ADP 0.00186 0.46318 3.97554
94 1JS8 MAN MAN BMA 0.01579 0.45361 3.97554
95 4AVB CMP 0.03134 0.4094 3.97554
96 5NFB 8VT 0.04807 0.41133 3.97727
97 3HAV ATP 0.001568 0.49363 4.01338
98 4CS9 AMP 0.01343 0.41488 4.2328
99 5DMZ ADP 0.00003264 0.54302 4.28135
100 2PYW ADP 0.0001327 0.50395 4.28135
101 3WVR AMP 0.001044 0.48013 4.28135
102 5L3S G 0.04524 0.4084 4.36242
103 2QX0 PH2 0.01045 0.44245 4.40252
104 5I35 ANP 0.00001741 0.56228 4.58716
105 3I0O ADP 0.0002859 0.51968 4.58716
106 3W0O ADP 0.004744 0.40953 4.58716
107 3W0O HY0 0.004744 0.40953 4.58716
108 1TZD ADP 0.002567 0.48432 4.72727
109 5MY8 RXZ 0.00000004016 0.63711 4.89297
110 1PK8 ATP 0.001509 0.44141 4.89297
111 2YW2 ATP 0.01024 0.41702 4.89297
112 1JJE BYS 0.02074 0.40282 4.95496
113 3VV1 GAL FUC 0.02485 0.41832 5
114 5I8T LAC 0.04838 0.41012 5.02793
115 3MKN DNB 0.03133 0.40296 5.06329
116 3T1A 5MA 0.01198 0.41694 5.19878
117 5GZ9 ANP 0.000001231 0.58499 5.2459
118 1M26 GAL A2G 0.01085 0.44721 5.26316
119 3VOT ADP 0.003847 0.46075 5.50459
120 4RDL FUC GAL NDG FUC 0.01827 0.43543 5.51948
121 5LXT ACP 0.01384 0.40532 5.59441
122 2BKK ADP 0.00149 0.47719 5.68182
123 4AZT LY2 0.0001418 0.53557 5.8104
124 4DSU BZI 0.0123 0.44709 5.82011
125 5TDF ADE 0.0009936 0.49765 5.8642
126 5TDF ADP 0.01513 0.40917 5.8642
127 4LI4 AMP 0.02039 0.42676 5.88235
128 4AZW ATP 0.001426 0.45651 6.11621
129 5DXT 5H5 0.003043 0.44495 6.11621
130 2HYV UAP SGN IDS SGN IDS 0.02303 0.42854 6.16883
131 4XBT 3ZQ 0.03273 0.40843 6.45161
132 4ZS4 ATP 0.000007781 0.56657 6.51466
133 4B1L FRU 0.02964 0.41736 6.66667
134 5NCY 8TK 0.000162 0.46824 6.72783
135 1CBK ROI 0.02573 0.4265 6.875
136 3F5A SIA GAL NAG 0.01614 0.43134 6.91057
137 2VPQ ANP 0.0003374 0.47694 7.03364
138 4Q5H ANP 0.0002901 0.49761 7.05128
139 1W2D ADP 0.002269 0.47274 7.16981
140 3PDT ADP 0.0000311 0.55626 7.27273
141 3HY2 ATP 0.04526 0.40797 7.27273
142 4U98 ACP 0.0009836 0.47671 7.33945
143 1OFZ FUC 0.04159 0.41525 7.37179
144 4RL0 3S0 0.04241 0.40258 7.43802
145 3KYG 5GP 5GP 0.00948 0.42174 7.48899
146 3K3K A8S 0.02351 0.40028 7.58294
147 1I7L ATP 0.0009974 0.45252 7.76699
148 3LEK BCW 0.0231 0.42406 7.84314
149 3X01 AMP 0.0002351 0.53899 7.95107
150 5FI4 5XV 0.003415 0.42923 8.04954
151 1EB1 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.01592 0.42457 8.17121
152 2ZL7 FUC GAL NGA 0.02791 0.42551 8.81356
153 3DZ6 PUT 0.04047 0.40123 8.95522
154 3ZJX BOG 0.001636 0.49409 8.99654
155 4O1P ANP 0.00000002011 0.69662 9.17431
156 3Q60 ATP 0.00001155 0.57098 9.17431
157 3ZW0 FUC 0.02477 0.4273 9.1954
158 1XDN ATP 0.01986 0.4161 9.38628
159 4F9C 0SX 0.000009822 0.57443 9.72222
160 4G17 0VN 0.00001829 0.56776 9.78593
161 4OUC 5ID 0.00002461 0.56133 9.80392
162 5BWD FUM 0.03247 0.42121 10
163 3SAO NKN 0.04206 0.40613 10
164 3DGY 2GP 0.03206 0.41997 10.3093
165 2PZI AXX 0.00001029 0.58739 10.3976
166 3K5I ADP 0.002053 0.44921 10.3976
167 2AGC DAO 0.0376 0.41236 10.4938
168 4PU5 ANP 0.001713 0.44565 10.7034
169 4JR7 GNP 0.000004009 0.58659 11.0092
170 1SLT NDG GAL 0.04465 0.40198 11.194
171 4YLL 4E3 0.000001004 0.58891 11.315
172 4LO2 GAL BGC 0.042 0.40339 11.5646
173 5KSP GDP 0.03636 0.40606 11.5789
174 4OAV ACP 0.0000000948 0.67286 11.6208
175 2CFM AMP 0.001202 0.48715 11.6208
176 3TD3 GLY 0.02534 0.42908 13.0081
177 2D6M LBT 0.03983 0.40902 13.2075
178 4WW7 AMP 0.00001115 0.5479 13.7931
179 4LRJ ANP 0.0000282 0.55206 14.2012
180 3RF4 FUN 0.0341 0.41861 14.6552
181 3LQV ADE 0.009521 0.42546 14.7826
182 5VCV 1N1 0.0000000198 0.65723 15.4341
183 4Y0X ADP 0.000000158 0.6707 17.0667
184 1BHX ASP PHE GLU GLU ILE 0.007142 0.4467 18.0952
185 4NST ADP 0.000000424 0.63328 18.2836
186 2DT9 THR 0.03559 0.41366 18.5629
187 3M2W L8I 0.0000005906 0.65068 19.398
188 4IJP 1EH 0.00000004407 0.46004 19.8777
189 3N7S 3N7 0.0383 0.41195 20
190 5VC5 96M 0.0000000003564 0.70918 20.4152
191 5K2M ADP 0.001769 0.44168 20.7547
192 3FHR P4O 0.000001599 0.5988 20.7951
193 3QCQ 3Q0 0.00000003899 0.43197 20.8333
194 4CRL C1I 0.00000002379 0.60477 21.4067
195 4LOO SB4 0.0001424 0.5124 22.0183
196 3OFM 4B0 0.0000004406 0.65717 22.2857
197 4WHZ 3NL 0.000008369 0.4601 22.3242
198 4IDT T28 0.0000006614 0.63165 22.63
199 4IZY 1J2 0.00000006801 0.65533 22.9358
200 5W4W 9WG 0.0000005859 0.56101 22.9358
201 5CKW ANP 0.00005065 0.55889 22.9358
202 4KBA 1QM 0.000004633 0.53911 22.9358
203 3ORK AGS 0.000003966 0.55179 23.4727
204 3C0G 3AM 0.0000003609 0.66159 23.5474
205 3PE2 E1B 0.0000009337 0.49937 23.7389
206 4D2S DYK 0.000000008059 0.74578 24.2958
207 5T8O 76Z 0.0000003558 0.62227 25.3823
208 2B9I ADP 0.0000008754 0.61821 25.3823
209 2B9J ADP 0.000001333 0.61679 25.3823
210 2YAB AMP 0.000001307 0.60291 25.3823
211 1CM8 ANP 0.00004038 0.54444 25.3823
212 2B9H ADP 0.0000003332 0.4351 25.3823
213 3PTG 932 0.000005013 0.61978 25.6881
214 3TTI KBI 0.000000805 0.57053 25.6881
215 1Q8Y ADE 0.000001366 0.64994 25.7373
216 1Q8Y ADP 0.000002821 0.5809 25.7373
217 2B9F ADP 0.0000007192 0.62229 25.9939
218 3E7O 35F 0.00000005771 0.59528 25.9939
219 1PHK ATP 0.000001074 0.60691 26.1745
220 4H3Q ANP 0.0000002635 0.61467 26.2997
221 2ZV2 609 0.0000001119 0.69742 26.8456
222 4H3P ANP 0.00000002018 0.69655 26.9113
223 4WNK 453 0.000001202 0.55343 26.9113
224 4XH0 ADP 0.000002305 0.65296 27.2171
225 5BVE 4VG 0.000005464 0.43018 27.2171
226 2YAK OSV 0.0000001019 0.5963 27.7193
227 5EFQ ADP 0.0000001412 0.65612 27.8287
228 4QTB 38Z 0.0000003166 0.58186 27.8287
229 3GC8 B45 0.000005017 0.56355 28.1346
230 2V7O DRN 0.00000009082 0.71282 28.4404
231 3E8N ATP 0.000001358 0.49836 28.4404
232 3E8N VRA 0.000001358 0.49836 28.4404
233 5LPZ ADP 0.0000000214 0.69533 28.7462
234 4OH4 ANP 0.00000004759 0.67872 28.7462
235 4BFM ANP 0.00000005471 0.65967 28.7462
236 1OUK 084 0.00000002285 0.41176 28.7462
237 5M06 ADP 0.0000006685 0.63945 28.9855
238 3ZRM ZRM 0.00000009091 0.66527 29.052
239 5X8I SQZ 0.0000001029 0.66269 29.052
240 3F7Z 34O 0.0000003783 0.63564 29.052
241 2JLD AG1 0.00000003339 0.59915 29.052
242 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.00001639 0.42788 29.052
243 2JDR L20 0.00001639 0.42788 29.052
244 4NM5 ADP 0.00000008549 0.63634 29.1667
245 1V0O INR 0.0000008658 0.6113 29.1667
246 4FG8 ATP 0.00000009243 0.6492 29.2063
247 2WEL K88 0.00000005218 0.74567 29.3578
248 5IH9 6BF 0.0000000004673 0.65758 29.6636
249 2R5T ANP 0.00001411 0.54327 29.6636
250 2VZ6 FEF 0.0000008861 0.6417 30.0319
251 3UIM ANP 0.0000005608 0.62746 30.0613
252 3MVH WFE 0.000003406 0.53534 30.581
253 4WB6 ATP 0.00000933 0.53114 30.581
254 4WB7 ATP 0.0001882 0.45006 30.581
255 3V8S 0HD 0.0000009335 0.62434 30.8869
256 4Y85 499 0.00003123 0.54989 30.8869
257 2QCS ANP 0.000007449 0.53525 30.8869
258 5LXC 7AA 0.0000002295 0.41932 30.8869
259 2VN9 GVD 0.00000004074 0.73142 30.897
260 5TA6 79D 0.00000000357 0.66781 31.1927
261 3GC0 AMP 0.000001055 0.63783 31.1927
262 5AWM ANP 0.000001676 0.63612 31.1927
263 4BTK DTQ 0.000008583 0.57077 31.1927
264 3IDB ANP 0.000004767 0.55894 31.1927
265 3FHI ANP 0.000008531 0.53277 31.1927
266 5BYZ 4WE 0.000009439 0.51349 31.1927
267 2GU8 796 0.0000006868 0.47043 31.1927
268 1RE8 BD2 0.00002164 0.46563 31.1927
269 5HQ0 LZ9 0.0000002513 0.62921 31.457
270 5LPB ADP 0.00000005519 0.71344 31.7568
271 3H9R TAK 0.00000003559 0.73455 31.8043
272 3PVW QRX 0.000005207 0.54179 31.8043
273 5UKL SIX 0.000009794 0.52567 31.8043
274 4AU8 Z3R 0.000005263 0.61019 32.0946
275 4EUU BX7 0.000001511 0.56437 32.2884
276 2BPM 529 0.00000006432 0.52613 32.3625
277 1UNH IXM 0.0000001363 0.68316 32.5342
278 3O0G 3O0 0.0000004801 0.42386 32.5342
279 4CFU 2WC 0.00000006514 0.6899 32.6733
280 4NFN 2KC 0.00002071 0.5586 32.6861
281 4X7Q 3YR 0.0000001643 0.65297 32.6923
282 3HMO STU 0.000000001228 0.76505 32.7217
283 3GNI ATP 0.0000008869 0.60402 32.7217
284 5AX9 4KT 0.0000004426 0.63238 32.7922
285 4BCM T7Z 0.0000002772 0.69768 32.8904
286 4BCQ TJF 0.000001674 0.63613 32.8904
287 4USF 6UI 0.0000006328 0.59173 32.8947
288 4BCN T9N 0.0000001051 0.68892 33
289 2HY0 306 0.00000001089 0.7391 33.0275
290 2RIO ADP 0.00000008731 0.6746 33.0275
291 5EKO N17 0.00000007783 0.63814 33.0275
292 2XMY CDK 0.0000002846 0.45614 33.2215
293 3GGF GVD 0.000000106 0.67935 33.2226
294 5LVP ATP 0.0000004539 0.65651 33.3333
295 5LMK 6ZK 0.000002548 0.61047 33.3333
296 4AUA 4AU 0.00001484 0.56567 33.3333
297 3TKI S25 0.0000002795 0.48926 33.3333
298 4N70 2HX 0.000002556 0.47657 33.3333
299 3SXF BK5 0.00009462 0.46421 33.3333
300 2WU6 DKI 0.00000000293 0.70127 33.6391
301 1XJD STU 0.0000006241 0.61797 33.945
302 4OTH DRN 0.0000004544 0.61064 33.945
303 3IGO ANP 0.00003084 0.52795 33.945
304 5N87 N66 0.0000000624 0.57888 34.1853
305 4L3L 5FI 0.000001111 0.46625 34.2105
306 5DBX ANP 0.0000005267 0.65322 34.2508
307 3ALN ANP 0.0000001816 0.6357 34.2508
308 5LI1 ANP 0.00000244 0.57768 34.2508
309 3TXO 07U 0.000002147 0.61417 34.5566
310 5LI9 ACP 0.000001489 0.60026 34.5566
311 4L9I 8PR 0.000003914 0.59394 34.5566
312 4YZC STU 0.00000004558 0.57911 34.5566
313 1ZY5 ANP 0.000003143 0.5986 34.9835
314 3CY2 MB9 0.0000004582 0.60402 35.0318
315 4BHN BH9 0.0000008846 0.60407 35.1682
316 4DC2 ADE 0.00000026 0.71196 36.3914
317 4A4X JUP 0.000000003787 0.67373 36.5591
318 5JZJ AN2 0.0000001293 0.66628 36.7003
319 2Z7R STU 0.0000001944 0.62728 36.7601
320 4NW6 2NS 0.000004443 0.52217 36.8421
321 4G31 0WH 0.00000613 0.51276 37.1237
322 5HVJ ANP 0.000006177 0.62512 37.4603
323 5UIU 8CG 0.0000001797 0.58645 37.4613
324 4Y8D 49J 0.00000006635 0.67182 37.6147
325 4ITH RCM 0.0007273 0.46597 38.0952
326 5L8L ADP 0.00000004799 0.71661 38.2456
327 5G1X ADP 0.0000001765 0.65968 38.2456
328 5LXM ADP 0.0000004063 0.64199 38.5159
329 4C2V YJA 0.0000001355 0.59136 38.5965
330 1O9U ADZ 0.02405 0.41191 38.8889
331 2WQN ADP 0.0000005118 0.65385 39.0323
332 4C2W ANP 0.00000001898 0.73762 39.4265
333 1VJY 460 0.0000001646 0.57764 39.604
334 5EYK 5U5 0.00000001045 0.64852 39.8551
335 2WEI VGG 0.000005227 0.5949 40.0697
336 4I94 ANP 0.000005255 0.58769 40.3333
337 4WOV 3SM 0.0000001669 0.67866 40.3785
338 2QLU ADE 0.000005185 0.62767 40.4459
339 5JGA 6KC 0.0000000002966 0.684 40.6349
340 5C03 AGS 0.00000454 0.58401 40.6728
341 2A19 ANP 0.00000002261 0.73365 40.8451
342 3E5A VX6 0.00000001009 0.66276 41.0448
343 4KS7 X4Z 0.00000003345 0.6544 41.0959
344 5DRB 5FJ 0.0000063 0.47256 41.5808
345 3HZT J60 0.000004188 0.61536 41.5902
346 3DAK ANP 0.00000003752 0.70185 42.4138
347 5UOX 8GY 0.0000004428 0.61114 42.4354
348 3KMW ATP 0.0000353 0.54729 42.4354
349 4WNP 3RJ 0.00000001049 0.73994 42.8571
350 4I6H 1C8 0.00000000927 0.71271 43.5065
351 5USZ SKE 0.0000001723 0.59821 43.9446
352 4FL3 ANP 0.000000003267 0.7074 44.3425
353 5KO1 6UY 0.00000003881 0.6918 44.523
354 4M69 ANP 0.000009104 0.55749 46.9965
355 4E93 GUI 0.0000000235 0.61041 49.8471
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