Receptor
PDB id Resolution Class Description Source Keywords
4E1O 1.8 Å EC: 4.1.1.22 HUMAN HISTIDINE DECARBOXYLASE COMPLEX WITH HISTIDINE METHYL (HME) HOMO SAPIENS HISTIDINE DECARBOXYLASE LYASE
Ref.: STRUCTURAL STUDY REVEALS THAT SER-354 DETERMINES SU SPECIFICITY ON HUMAN HISTIDINE DECARBOXYLASE J.BIOL.CHEM. V. 287 29175 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PLP PVH A:1000;
B:1000;
C:1000;
D:1000;
E:1000;
F:1000;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
submit data
396.296 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4E1O 1.8 Å EC: 4.1.1.22 HUMAN HISTIDINE DECARBOXYLASE COMPLEX WITH HISTIDINE METHYL (HME) HOMO SAPIENS HISTIDINE DECARBOXYLASE LYASE
Ref.: STRUCTURAL STUDY REVEALS THAT SER-354 DETERMINES SU SPECIFICITY ON HUMAN HISTIDINE DECARBOXYLASE J.BIOL.CHEM. V. 287 29175 2012
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4E1O - PLP PVH n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4E1O - PLP PVH n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 1JS3 - PLP 142 n/a n/a
2 4E1O - PLP PVH n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PLP PVH; Similar ligands found: 23
No: Ligand ECFP6 Tc MDL keys Tc
1 PLP PVH 1 1
2 MET PLP 0.58427 0.761194
3 PLP PHE 0.553191 0.793651
4 PLP 999 0.539326 0.765625
5 KOU 0.517241 0.746269
6 PL6 0.478261 0.731343
7 PLP PUT 0.467391 0.710145
8 EQJ 0.464646 0.732394
9 5DK 0.464646 0.732394
10 PUS 0.463918 0.716216
11 PL5 0.463918 0.724638
12 P70 0.463918 0.769231
13 PLT 0.461538 0.818182
14 F0G 0.455556 0.765625
15 PLP MYB 0.45098 0.657895
16 EPC 0.443182 0.734375
17 0JO 0.428571 0.720588
18 4LM 0.428571 0.731343
19 FEJ 0.427083 0.731343
20 6DF 0.416667 0.723077
21 PLP 142 0.412844 0.746479
22 FEV 0.404255 0.720588
23 EVM 0.4 0.761194
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4E1O; Ligand: PLP PVH; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 4e1o.bio3) has 24 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 4E1O; Ligand: PLP PVH; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4e1o.bio3) has 24 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback