Receptor
PDB id Resolution Class Description Source Keywords
4EOQ 2.15 Å EC: 2.7.11.22 THR 160 PHOSPHORYLATED CDK2 WT - HUMAN CYCLIN A3 COMPLEX WIT HOMO SAPIENS PROTEIN KINASE CELL CYCLE COMPLEX PHOSPHORYLATION TRANSF
Ref.: AN INTEGRATED CHEMICAL BIOLOGY APPROACH PROVIDES IN INTO CDK2 FUNCTIONAL REDUNDANCY AND INHIBITOR SENSI CHEM.BIOL. V. 19 1028 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ATP C:301;
A:301;
Valid;
Valid;
none;
none;
submit data
507.181 C10 H16 N5 O13 P3 c1nc(...
SGM D:501;
B:502;
Invalid;
Invalid;
none;
none;
submit data
108.159 C3 H8 O2 S C([C@...
MG B:501;
A:302;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2BPM 2.4 Å EC: 2.7.11.22 STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529 HOMO SAPIENS PROTEIN KINASE TRANSFERASE SERINE/THREONINE-PROTEIN KINASE PHOSPHORYLATION CELL DIVISION CYCLIN
Ref.: 3-AMINOPYRAZOLE INHIBITORS OF CDK2-CYCLIN A AS ANTITUMOR AGENTS. 2. LEAD OPTIMIZATION J.MED.CHEM. V. 48 2944 2005
Members (55)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 13 families.
1 4CFN ic50 = 49 uM JYM C13 H16 F3 N5 O C1CCC(CC1)....
2 3BHU ic50 = 0.003 uM MHR C14 H15 N5 O CCCOc1ccnc....
3 1E9H ic50 = 35 nM INR C16 H10 N2 O5 S c1ccc2c(c1....
4 4EOL - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
5 1OIU ic50 = 0.21 uM N76 C18 H22 N6 O3 S c1cc(cc(c1....
6 3BHV ic50 = 0.08 uM VAR C14 H11 N7 O c1cnc(n2c1....
7 4EOQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
8 2G9X ic50 = 45 nM NU5 C23 H32 N6 O4 S c1cc(ccc1N....
9 3MY5 ic50 = 65 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
10 1P5E - TBS C6 H Br4 N3 c12c(c(c(c....
11 2IW6 ic50 = 0.14 uM QQ2 C24 H27 Cl N6 O2 Cc1ccc(c(c....
12 1OKV ic50 = 0.68 uM ARG ARG LEU ILE PHE NH2 n/a n/a
13 1H1R ic50 = 2.3 uM 6CP C18 H20 Cl N5 O c1cc(cc(c1....
14 1OKW ic50 = 5.6 uM ACE ARG ARG LEU ASN FCL NH2 n/a n/a
15 1OI9 ic50 = 69 nM N20 C18 H21 N5 O2 c1cc(ccc1N....
16 4EON - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
17 4EOJ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
18 2UZE ic50 = 48 uM C95 C15 H10 N2 O4 S [H]/N=C/1N....
19 1PKD - UCN C28 H26 N4 O4 C[C@@]12[C....
20 4CFV ic50 = 23.5 uM 75X C19 H23 N5 O2 Cc1c(cccc1....
21 3BHT ic50 = 0.011 uM MFR C12 H11 N5 O COc1ccnc2c....
22 2IW8 ic50 = 103 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
23 4BCO Ki = 0.131 uM T6Q C23 H26 N8 O S Cc1c(sc(n1....
24 2UUE ic50 = 1.3 uM ARG LEU ILE PFF NH2 GVC n/a n/a
25 1FIN - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
26 4EOI - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
27 4II5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
28 1VYW ic50 = 37 nM 292 C18 H17 N3 O c1ccc2cc(c....
29 2UZL ic50 = 0.61 uM C94 C15 H10 F3 N3 O4 S2 [H]/N=C/1N....
30 1H24 Kd = 0.5 uM PRO VAL LYS ARG ARG LEU ASP LEU GLU n/a n/a
31 1H1Q ic50 = 1 uM 2A6 C18 H21 N5 O c1ccc(cc1)....
32 3DDQ ic50 ~ 28 uM RRC C19 H26 N6 O CC[C@H](CO....
33 2WEV ic50 = 30 uM ACE ARG ARG B3L MEA NH2 n/a n/a
34 1OIY ic50 ~ 64 nM N41 C19 H22 N6 O2 c1cc(ccc1C....
35 4I3Z Kd = 51.3 mM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
36 4EOP - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
37 2C5O ic50 = 6.5 uM CK2 C9 H10 N4 S Cc1c(sc(n1....
38 2WIH ic50 = 0.045 uM P48 C25 H32 N8 O CC1(Cc2cnc....
39 2IW9 ic50 = 8.9 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
40 4EOO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
41 2BPM ic50 = 2 nM 529 C18 H19 N5 O2 C[C@@H](c1....
42 1H1S Ki = 6 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
43 2C5N ic50 = 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
44 4BCP Ki = 568 nM T3C C21 H24 N8 S Cc1c(sc(n1....
45 3F5X ic50 = 1040 nM EZV C25 H25 N7 CN1CCN(CC1....
46 3QHR - PRO LYS THR PRO LYS LYS ALA LYS LYS LEU n/a n/a
47 4BCK Ki = 0.004 uM T3E C16 H15 N7 O2 S2 Cc1c(sc(n1....
48 1H1P Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
49 4EOR Ki = 500 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
50 1QMZ - HIS HIS ALA SER PRO ARG LYS n/a n/a
51 4EOM - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
52 2CJM - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
53 3QHW - PRO LYS THR PRO LYS LYS ALA LYS LYS LEU n/a n/a
54 3TNW - F18 C9 H10 N6 O c1cc(ccc1/....
55 4CFW ic50 = 0.51 uM SQ9 C19 H24 N6 O3 S Cc1c(cccc1....
70% Homology Family (55)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 11 families.
1 4CFN ic50 = 49 uM JYM C13 H16 F3 N5 O C1CCC(CC1)....
2 3BHU ic50 = 0.003 uM MHR C14 H15 N5 O CCCOc1ccnc....
3 1E9H ic50 = 35 nM INR C16 H10 N2 O5 S c1ccc2c(c1....
4 4EOL - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
5 1OIU ic50 = 0.21 uM N76 C18 H22 N6 O3 S c1cc(cc(c1....
6 3BHV ic50 = 0.08 uM VAR C14 H11 N7 O c1cnc(n2c1....
7 4EOQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
8 2G9X ic50 = 45 nM NU5 C23 H32 N6 O4 S c1cc(ccc1N....
9 3MY5 ic50 = 65 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
10 1P5E - TBS C6 H Br4 N3 c12c(c(c(c....
11 2IW6 ic50 = 0.14 uM QQ2 C24 H27 Cl N6 O2 Cc1ccc(c(c....
12 1OKV ic50 = 0.68 uM ARG ARG LEU ILE PHE NH2 n/a n/a
13 1H1R ic50 = 2.3 uM 6CP C18 H20 Cl N5 O c1cc(cc(c1....
14 1OKW ic50 = 5.6 uM ACE ARG ARG LEU ASN FCL NH2 n/a n/a
15 1OI9 ic50 = 69 nM N20 C18 H21 N5 O2 c1cc(ccc1N....
16 4EON - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
17 4EOJ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
18 2UZE ic50 = 48 uM C95 C15 H10 N2 O4 S [H]/N=C/1N....
19 1PKD - UCN C28 H26 N4 O4 C[C@@]12[C....
20 4CFV ic50 = 23.5 uM 75X C19 H23 N5 O2 Cc1c(cccc1....
21 3BHT ic50 = 0.011 uM MFR C12 H11 N5 O COc1ccnc2c....
22 2IW8 ic50 = 103 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
23 4BCO Ki = 0.131 uM T6Q C23 H26 N8 O S Cc1c(sc(n1....
24 2UUE ic50 = 1.3 uM ARG LEU ILE PFF NH2 GVC n/a n/a
25 1FIN - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
26 4EOI - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
27 4II5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
28 1VYW ic50 = 37 nM 292 C18 H17 N3 O c1ccc2cc(c....
29 2UZL ic50 = 0.61 uM C94 C15 H10 F3 N3 O4 S2 [H]/N=C/1N....
30 1H24 Kd = 0.5 uM PRO VAL LYS ARG ARG LEU ASP LEU GLU n/a n/a
31 1H1Q ic50 = 1 uM 2A6 C18 H21 N5 O c1ccc(cc1)....
32 3DDQ ic50 ~ 28 uM RRC C19 H26 N6 O CC[C@H](CO....
33 2WEV ic50 = 30 uM ACE ARG ARG B3L MEA NH2 n/a n/a
34 1OIY ic50 ~ 64 nM N41 C19 H22 N6 O2 c1cc(ccc1C....
35 4I3Z Kd = 51.3 mM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
36 4EOP - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
37 2C5O ic50 = 6.5 uM CK2 C9 H10 N4 S Cc1c(sc(n1....
38 2WIH ic50 = 0.045 uM P48 C25 H32 N8 O CC1(Cc2cnc....
39 2IW9 ic50 = 8.9 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
40 4EOO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
41 2BPM ic50 = 2 nM 529 C18 H19 N5 O2 C[C@@H](c1....
42 1H1S Ki = 6 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
43 2C5N ic50 = 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
44 4BCP Ki = 568 nM T3C C21 H24 N8 S Cc1c(sc(n1....
45 3F5X ic50 = 1040 nM EZV C25 H25 N7 CN1CCN(CC1....
46 3QHR - PRO LYS THR PRO LYS LYS ALA LYS LYS LEU n/a n/a
47 4BCK Ki = 0.004 uM T3E C16 H15 N7 O2 S2 Cc1c(sc(n1....
48 1H1P Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
49 4EOR Ki = 500 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
50 1QMZ - HIS HIS ALA SER PRO ARG LYS n/a n/a
51 4EOM - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
52 2CJM - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
53 3QHW - PRO LYS THR PRO LYS LYS ALA LYS LYS LEU n/a n/a
54 3TNW - F18 C9 H10 N6 O c1cc(ccc1/....
55 4CFW ic50 = 0.51 uM SQ9 C19 H24 N6 O3 S Cc1c(cccc1....
50% Homology Family (55)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 4CFN ic50 = 49 uM JYM C13 H16 F3 N5 O C1CCC(CC1)....
2 3BHU ic50 = 0.003 uM MHR C14 H15 N5 O CCCOc1ccnc....
3 1E9H ic50 = 35 nM INR C16 H10 N2 O5 S c1ccc2c(c1....
4 4EOL - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
5 1OIU ic50 = 0.21 uM N76 C18 H22 N6 O3 S c1cc(cc(c1....
6 3BHV ic50 = 0.08 uM VAR C14 H11 N7 O c1cnc(n2c1....
7 4EOQ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
8 2G9X ic50 = 45 nM NU5 C23 H32 N6 O4 S c1cc(ccc1N....
9 3MY5 ic50 = 65 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
10 1P5E - TBS C6 H Br4 N3 c12c(c(c(c....
11 2IW6 ic50 = 0.14 uM QQ2 C24 H27 Cl N6 O2 Cc1ccc(c(c....
12 1OKV ic50 = 0.68 uM ARG ARG LEU ILE PHE NH2 n/a n/a
13 1H1R ic50 = 2.3 uM 6CP C18 H20 Cl N5 O c1cc(cc(c1....
14 1OKW ic50 = 5.6 uM ACE ARG ARG LEU ASN FCL NH2 n/a n/a
15 1OI9 ic50 = 69 nM N20 C18 H21 N5 O2 c1cc(ccc1N....
16 4EON - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
17 4EOJ - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
18 2UZE ic50 = 48 uM C95 C15 H10 N2 O4 S [H]/N=C/1N....
19 1PKD - UCN C28 H26 N4 O4 C[C@@]12[C....
20 4CFV ic50 = 23.5 uM 75X C19 H23 N5 O2 Cc1c(cccc1....
21 3BHT ic50 = 0.011 uM MFR C12 H11 N5 O COc1ccnc2c....
22 2IW8 ic50 = 103 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
23 4BCO Ki = 0.131 uM T6Q C23 H26 N8 O S Cc1c(sc(n1....
24 2UUE ic50 = 1.3 uM ARG LEU ILE PFF NH2 GVC n/a n/a
25 1FIN - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
26 4EOI - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
27 4II5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
28 1VYW ic50 = 37 nM 292 C18 H17 N3 O c1ccc2cc(c....
29 2UZL ic50 = 0.61 uM C94 C15 H10 F3 N3 O4 S2 [H]/N=C/1N....
30 1H24 Kd = 0.5 uM PRO VAL LYS ARG ARG LEU ASP LEU GLU n/a n/a
31 1H1Q ic50 = 1 uM 2A6 C18 H21 N5 O c1ccc(cc1)....
32 3DDQ ic50 ~ 28 uM RRC C19 H26 N6 O CC[C@H](CO....
33 2WEV ic50 = 30 uM ACE ARG ARG B3L MEA NH2 n/a n/a
34 1OIY ic50 ~ 64 nM N41 C19 H22 N6 O2 c1cc(ccc1C....
35 4I3Z Kd = 51.3 mM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
36 4EOP - 1RO C18 H13 N3 O S2 c1cc2cc(cc....
37 2C5O ic50 = 6.5 uM CK2 C9 H10 N4 S Cc1c(sc(n1....
38 2WIH ic50 = 0.045 uM P48 C25 H32 N8 O CC1(Cc2cnc....
39 2IW9 ic50 = 8.9 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
40 4EOO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
41 2BPM ic50 = 2 nM 529 C18 H19 N5 O2 C[C@@H](c1....
42 1H1S Ki = 6 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
43 2C5N ic50 = 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
44 4BCP Ki = 568 nM T3C C21 H24 N8 S Cc1c(sc(n1....
45 3F5X ic50 = 1040 nM EZV C25 H25 N7 CN1CCN(CC1....
46 3QHR - PRO LYS THR PRO LYS LYS ALA LYS LYS LEU n/a n/a
47 4BCK Ki = 0.004 uM T3E C16 H15 N7 O2 S2 Cc1c(sc(n1....
48 1H1P Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
49 4EOR Ki = 500 nM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
50 1QMZ - HIS HIS ALA SER PRO ARG LYS n/a n/a
51 4EOM - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
52 2CJM - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
53 3QHW - PRO LYS THR PRO LYS LYS ALA LYS LYS LEU n/a n/a
54 3TNW - F18 C9 H10 N6 O c1cc(ccc1/....
55 4CFW ic50 = 0.51 uM SQ9 C19 H24 N6 O3 S Cc1c(cccc1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ATP; Similar ligands found: 404
No: Ligand ECFP6 Tc MDL keys Tc
1 ATP 1 1
2 AQP 0.985507 1
3 5FA 0.985507 1
4 B4P 0.927536 0.971831
5 AP5 0.927536 0.971831
6 BA3 0.913043 0.971831
7 ADP 0.9 1
8 A2D 0.884058 0.971831
9 SAP 0.84 0.945946
10 AGS 0.84 0.945946
11 AN2 0.810811 0.985915
12 25L 0.809524 0.985915
13 APR 0.802632 0.971831
14 AR6 0.802632 0.971831
15 M33 0.8 0.958333
16 TAT 0.794872 0.958904
17 ACQ 0.794872 0.972222
18 AD9 0.792208 0.972222
19 ACP 0.789474 0.972222
20 A 0.788732 0.971429
21 AMP 0.788732 0.971429
22 ANP 0.772152 0.972222
23 ADX 0.753247 0.873418
24 CA0 0.753247 0.945205
25 A22 0.746988 0.985915
26 50T 0.74359 0.958333
27 APC 0.734177 0.958904
28 PRX 0.734177 0.893333
29 ABM 0.733333 0.917808
30 ATF 0.731707 0.958904
31 ITT 0.730769 0.943662
32 7D4 0.730769 0.905405
33 ADQ 0.729412 0.945205
34 AMP MG 0.72 0.891892
35 AP2 0.714286 0.958904
36 A12 0.714286 0.958904
37 A1R 0.709302 0.907895
38 SRA 0.706667 0.918919
39 5AL 0.698795 0.931507
40 OAD 0.693182 0.945205
41 ADP MG 0.6875 0.905405
42 AU1 0.6875 0.972222
43 SRP 0.682353 0.906667
44 G5P 0.680851 0.921053
45 BEF ADP 0.679012 0.881579
46 ADP BEF 0.679012 0.881579
47 25A 0.678161 0.971831
48 3OD 0.677778 0.945205
49 4AD 0.670455 0.92
50 G3A 0.670213 0.921053
51 00A 0.662921 0.883117
52 ADV 0.662651 0.932432
53 ADP PO3 0.662651 0.943662
54 RBY 0.662651 0.932432
55 BIS 0.659341 0.933333
56 5SV 0.659091 0.848101
57 8QN 0.659091 0.931507
58 OOB 0.659091 0.931507
59 GTA 0.65625 0.886076
60 ATP MG 0.654762 0.905405
61 UP5 0.653061 0.92
62 AMO 0.651685 0.932432
63 PAJ 0.651685 0.884615
64 2A5 0.650602 0.918919
65 MAP 0.647727 0.945946
66 3AT 0.647059 0.971831
67 AHX 0.644444 0.896104
68 DLL 0.644444 0.931507
69 PAP 0.642857 0.985714
70 ATR 0.642857 0.971429
71 PTJ 0.641304 0.896104
72 7D3 0.6375 0.905405
73 3UK 0.637363 0.918919
74 SON 0.634146 0.932432
75 A4P 0.633663 0.843373
76 ALF ADP 0.632184 0.87013
77 ADP ALF 0.632184 0.87013
78 LAD 0.630435 0.860759
79 WAQ 0.630435 0.883117
80 PR8 0.630435 0.85
81 AFH 0.628866 0.884615
82 DTP 0.627907 0.905405
83 GAP 0.627907 0.893333
84 ANP MG 0.625 0.894737
85 VO4 ADP 0.625 0.931507
86 ADP VO4 0.625 0.931507
87 1ZZ 0.623656 0.839506
88 TXA 0.623656 0.932432
89 FYA 0.623656 0.905405
90 ME8 0.623656 0.839506
91 NB8 0.623656 0.896104
92 T5A 0.621359 0.841463
93 RAB 0.619718 0.84507
94 ADN 0.619718 0.84507
95 XYA 0.619718 0.84507
96 9SN 0.610526 0.871795
97 48N 0.61 0.896104
98 AP0 0.607843 0.896104
99 FA5 0.604167 0.906667
100 YAP 0.604167 0.894737
101 TXD 0.60396 0.907895
102 6V0 0.60396 0.896104
103 NXX 0.60396 0.932432
104 NAI 0.60396 0.907895
105 DND 0.60396 0.932432
106 NAX 0.60396 0.873418
107 ADP BMA 0.602151 0.918919
108 A2R 0.6 0.985915
109 OMR 0.598039 0.851852
110 TXE 0.598039 0.907895
111 XAH 0.597938 0.839506
112 DAL AMP 0.593407 0.905405
113 7DT 0.593023 0.985714
114 AOC 0.592593 0.821918
115 4UV 0.591837 0.894737
116 DDS 0.590909 0.878378
117 139 0.590476 0.873418
118 CNA 0.584906 0.932432
119 6AD 0.58427 0.909091
120 5AS 0.583333 0.77907
121 5N5 0.581081 0.819444
122 4UU 0.58 0.894737
123 4TC 0.576923 0.896104
124 ADJ 0.575472 0.851852
125 5CD 0.573333 0.805556
126 A4D 0.573333 0.819444
127 RGT 0.571429 0.958904
128 A3P 0.571429 0.971429
129 7D5 0.56962 0.878378
130 LAQ 0.568627 0.839506
131 YLP 0.563107 0.819277
132 A A 0.5625 0.944444
133 UPA 0.561905 0.907895
134 AV2 0.56044 0.917808
135 COD 0.559633 0.811765
136 4UW 0.557692 0.860759
137 JB6 0.556701 0.883117
138 3AM 0.555556 0.929577
139 ATP A A A 0.555556 0.930556
140 A2P 0.552941 0.957143
141 TYM 0.552381 0.906667
142 NA7 0.552083 0.958904
143 EP4 0.551282 0.753247
144 MYR AMP 0.55102 0.817073
145 PPS 0.549451 0.873418
146 YLB 0.54717 0.819277
147 YLC 0.54717 0.839506
148 NAD 0.545455 0.931507
149 DAT 0.545455 0.905405
150 G5A 0.544444 0.77907
151 M2T 0.544304 0.734177
152 DTA 0.544304 0.786667
153 3DH 0.54321 0.773333
154 128 0.542857 0.776471
155 AHZ 0.538462 0.817073
156 SSA 0.537634 0.8
157 GTP 0.537634 0.92
158 MTA 0.5375 0.773333
159 IOT 0.537037 0.831325
160 A3D 0.535714 0.918919
161 TYR AMP 0.534653 0.881579
162 AR6 AR6 0.533981 0.917808
163 7MD 0.533981 0.8625
164 YLA 0.53211 0.819277
165 AMP DBH 0.529412 0.893333
166 IMO 0.529412 0.929577
167 TAD 0.528846 0.884615
168 AYB 0.527273 0.809524
169 A5A 0.526882 0.807229
170 TSB 0.526316 0.819277
171 EAD 0.525424 0.873418
172 2AM 0.52439 0.943662
173 6RE 0.52381 0.759494
174 7DD 0.522727 0.985714
175 V3L 0.521739 0.971831
176 AVV 0.520833 0.896104
177 BTX 0.517857 0.841463
178 NAE 0.517241 0.894737
179 54H 0.515789 0.788235
180 VMS 0.515789 0.788235
181 52H 0.515789 0.77907
182 NSS 0.515464 0.8
183 BT5 0.513274 0.831325
184 NAQ 0.512821 0.871795
185 ZAS 0.511905 0.766234
186 A3N 0.511628 0.786667
187 J7C 0.511628 0.769231
188 5X8 0.511111 0.763158
189 53H 0.510417 0.77907
190 5CA 0.510417 0.8
191 ARU 0.510204 0.860759
192 ARG AMP 0.509434 0.829268
193 AF3 ADP 3PG 0.509259 0.8375
194 LA8 ALF 3PG 0.509259 0.8375
195 ALF ADP 3PG 0.509259 0.8375
196 ZID 0.508475 0.918919
197 P1H 0.508197 0.851852
198 OVE 0.505882 0.905405
199 S4M 0.505747 0.666667
200 LPA AMP 0.504673 0.817073
201 7MC 0.504587 0.841463
202 DZD 0.5 0.884615
203 LSS 0.5 0.761364
204 DSZ 0.5 0.8
205 P5A 0.5 0.744444
206 DSH 0.5 0.725
207 FB0 0.5 0.804598
208 MAO 0.5 0.759036
209 NDE 0.495935 0.932432
210 N0B 0.495798 0.819277
211 M24 0.495726 0.85
212 YLY 0.495726 0.809524
213 NJP 0.495575 0.945946
214 NVA LMS 0.494949 0.761364
215 MGP 0.494737 0.884615
216 6C6 0.494624 0.881579
217 NAJ PZO 0.491379 0.848101
218 0WD 0.491228 0.921053
219 LEU LMS 0.49 0.761364
220 6G0 0.489583 0.884615
221 GJV 0.488636 0.75
222 6FA 0.488189 0.841463
223 5AD 0.486842 0.746479
224 GSU 0.485149 0.77907
225 KAA 0.485149 0.752809
226 71V 0.483146 0.907895
227 NEC 0.482759 0.746667
228 A3G 0.482759 0.8
229 NAD IBO 0.482456 0.87013
230 ODP 0.482456 0.909091
231 FAS 0.48062 0.851852
232 FAD 0.48062 0.851852
233 7D7 0.480519 0.743243
234 FDA 0.480315 0.833333
235 N6P 0.48 0.915493
236 2SA 0.479167 0.932432
237 GP3 0.478723 0.921053
238 4TA 0.478261 0.807229
239 G A A A 0.478261 0.871795
240 SFG 0.478261 0.75
241 NPW 0.477876 0.886076
242 NDP 0.477876 0.921053
243 NDC 0.47619 0.871795
244 YSA 0.47619 0.77907
245 MGO 0.474227 0.860759
246 6IA 0.473684 0.8375
247 TXP 0.473684 0.921053
248 GDP 0.473684 0.92
249 NZQ 0.473684 0.909091
250 A7D 0.472527 0.776316
251 SFD 0.469231 0.734043
252 ZDA 0.468085 0.864865
253 SA8 0.468085 0.707317
254 A5D 0.468085 0.786667
255 12D 0.46789 0.785714
256 PGS 0.467391 0.883117
257 MHZ 0.467391 0.697674
258 62F 0.466165 0.8625
259 DA 0.465909 0.878378
260 D5M 0.465909 0.878378
261 GGZ 0.464646 0.825
262 SAH 0.463158 0.74359
263 SAI 0.463158 0.734177
264 NAJ PYZ 0.46281 0.85
265 FAY 0.462687 0.8625
266 Y3J 0.4625 0.726027
267 PO4 PO4 A A A A PO4 0.460784 0.902778
268 AAM 0.460674 0.971429
269 RFL 0.459259 0.821429
270 SMM 0.459184 0.686047
271 AMZ 0.458824 0.916667
272 C2R 0.458824 0.90411
273 SAM 0.458333 0.690476
274 A3S 0.456522 0.810811
275 FNK 0.455224 0.804598
276 7C5 0.453704 0.818182
277 AAT 0.453608 0.707317
278 EEM 0.453608 0.690476
279 XNP 0.452991 0.873418
280 AIR 0.451219 0.901408
281 62X 0.45098 0.666667
282 GSP 0.45 0.873418
283 ETB 0.45 0.833333
284 DCA 0.45 0.823529
285 U A G G 0.449153 0.883117
286 NIA 0.448276 0.822785
287 AMP NAD 0.447154 0.881579
288 A3T 0.446809 0.821918
289 K15 0.446602 0.682353
290 A A A 0.446602 0.905405
291 PUA 0.446281 0.884615
292 6K6 0.445545 0.930556
293 GEK 0.445545 0.7375
294 4YB 0.445455 0.761364
295 S7M 0.444444 0.690476
296 DG1 0.443548 0.921053
297 1DG 0.443548 0.921053
298 Z5A 0.443548 0.77907
299 COA 0.442623 0.823529
300 0T1 0.442623 0.823529
301 WSA 0.442478 0.788235
302 8BR 0.43956 0.906667
303 101 0.438202 0.878378
304 IDP 0.4375 0.918919
305 NAP 0.435484 0.945205
306 APU 0.434783 0.894737
307 A U 0.434783 0.87013
308 7RP 0.433333 0.928571
309 A6D 0.432692 0.722892
310 CAO 0.432 0.795455
311 AMX 0.432 0.833333
312 COS 0.432 0.804598
313 TAP 0.432 0.907895
314 J7V 0.432 0.833333
315 30N 0.432 0.752688
316 V1N 0.431193 0.917808
317 649 0.429825 0.744444
318 P5F 0.429577 0.823529
319 NA0 0.428571 0.932432
320 CMX 0.428571 0.823529
321 7RA 0.428571 0.957747
322 SCO 0.428571 0.823529
323 0UM 0.427184 0.698795
324 GAV 0.427184 0.884615
325 ACK 0.426966 0.861111
326 1RB 0.426966 0.885714
327 QQY 0.426966 0.815789
328 GCP 0.425743 0.896104
329 G1R 0.425743 0.907895
330 FAM 0.425197 0.804598
331 FCX 0.425197 0.795455
332 ACO 0.425197 0.795455
333 GNH 0.424242 0.907895
334 F2N 0.423611 0.813953
335 GDC 0.422018 0.884615
336 GDD 0.422018 0.884615
337 GKE 0.422018 0.884615
338 HAX 0.421875 0.804598
339 3AD 0.421687 0.805556
340 GNP 0.421569 0.896104
341 FA9 0.42069 0.864198
342 KB1 0.420561 0.698795
343 TM1 0.420561 0.77381
344 H6Y 0.42 0.945205
345 2MC 0.419847 0.769231
346 3KK 0.418605 0.804598
347 FYN 0.418605 0.823529
348 S8M 0.417476 0.759494
349 2VA 0.416667 0.8
350 NHD 0.416667 0.905405
351 26A 0.416667 0.763158
352 QQX 0.41573 0.805195
353 SOP 0.415385 0.804598
354 OXK 0.415385 0.804598
355 COK 0.415385 0.804598
356 MCD 0.415385 0.804598
357 CA6 0.415385 0.729167
358 YE1 0.413534 0.813953
359 FAI 0.413043 0.916667
360 AS 0.413043 0.833333
361 RMB 0.413043 0.873239
362 1VU 0.412214 0.795455
363 CO6 0.412214 0.804598
364 CMC 0.412214 0.804598
365 NMX 0.412214 0.76087
366 SXZ 0.411215 0.710843
367 ANZ 0.410714 0.8
368 SCA 0.410448 0.804598
369 PLP AAD 0.409836 0.741573
370 SCD 0.409091 0.823529
371 CAJ 0.409091 0.804598
372 NAD BBN 0.408759 0.841463
373 NVA 2AD 0.408163 0.74359
374 D3Y 0.407767 0.789474
375 CC5 0.407407 0.816901
376 U G A 0.407407 0.839506
377 KH3 0.40708 0.674419
378 SLU 0.406504 0.770115
379 G 0.40625 0.906667
380 5GP 0.40625 0.906667
381 BCO 0.406015 0.804598
382 IVC 0.406015 0.813953
383 A1S 0.406015 0.804598
384 MLC 0.406015 0.804598
385 3HC 0.406015 0.813953
386 1HE 0.406015 0.786517
387 GTG 0.405405 0.886076
388 NMN AMP PO4 0.404959 0.87013
389 3D1 0.404762 0.773333
390 3L1 0.404762 0.773333
391 CMP 0.404255 0.901408
392 2BA 0.404255 0.915493
393 SO8 0.40404 0.789474
394 VRT 0.40404 0.769231
395 MCA 0.402985 0.795455
396 CAA 0.402985 0.813953
397 COO 0.402985 0.804598
398 NAD CJ3 0.402878 0.811765
399 G2R 0.401869 0.884615
400 3NZ 0.401869 0.782051
401 ZZB 0.4 0.77381
402 MC4 0.4 0.76087
403 2FA 0.4 0.813333
404 2CP 0.4 0.795455
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2BPM; Ligand: 529; Similar sites found: 208
This union binding pocket(no: 1) in the query (biounit: 2bpm.bio1) has 47 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5GZ9 ANP 0.0000002606 0.43729 3.01887
2 3TPV ADE 0.01344 0.41809 3.01887
3 4GYI ADP 0.0001206 0.53745 3.39623
4 2B6N ALA PRO THR 0.02951 0.42026 3.39623
5 2YW2 ATP 0.002978 0.44562 4.15094
6 5I35 ANP 0.0000004034 0.40312 4.5283
7 4OCJ NDG 0.0001379 0.41074 4.53074
8 3TM0 ANP 0.0006394 0.44271 5.32319
9 3TM0 B31 0.0007658 0.43689 5.32319
10 5NCY 8TK 0.00002873 0.4113 5.66038
11 2XG5 EC2 0.01996 0.42448 5.78035
12 2XG5 EC5 0.01996 0.42448 5.78035
13 4ANW O92 0.000003745 0.44008 6.03774
14 5EQY 5RA 0.0005235 0.4146 6.41509
15 1IA9 ANP 0.00002699 0.54615 7.54717
16 4OFG PCG 0.0222 0.42053 7.63889
17 4O1P ANP 0.00000001452 0.43751 8.09062
18 3W0O ADP 0.00003186 0.40828 8.09062
19 3W0O HY0 0.00003186 0.40828 8.09062
20 4PU5 ANP 0.003492 0.43573 8.41424
21 1Z2P ACP 0.004023 0.40037 8.73786
22 1Z2P I3S 0.004023 0.40037 8.73786
23 2V68 CAP 0.02663 0.4011 9.0566
24 5DMZ ADP 0.000002157 0.40537 9.43396
25 1TQP ATP 0.00001109 0.40788 10.9929
26 5IQD RIO 0.00001213 0.4428 11.8033
27 5IQD GNP 0.00001019 0.4421 11.8033
28 4NZN 2OU 0.001066 0.41048 12.4528
29 4NZN ANP 0.001066 0.41048 12.4528
30 3SJK LYS PRO VAL LEU ARG THR ALA 0.009166 0.45573 13.1579
31 4WW7 AMP 0.0000003583 0.42667 17.1123
32 4DFU QUE 0.003308 0.47828 18.0124
33 4OAV ACP 0.00000003798 0.42241 18.123
34 5C4L 4XR 0.00001258 0.42192 18.3801
35 5C4L SIS 0.00001422 0.42014 18.3801
36 3ZJX BOG 0.00999 0.45244 18.4906
37 5VC5 96M 0.000000003331 0.49903 23.1834
38 4BTK DTQ 0.0000001909 0.42318 23.6246
39 3VHE 42Q 0.000001234 0.44463 25.2427
40 5KO1 6UY 0.0000002718 0.40838 25.7951
41 5W4W 9WG 0.0000008448 0.45283 25.89
42 4KBA 1QM 0.00001451 0.41019 25.89
43 4XH0 ADP 0.000001625 0.6662 27.8317
44 4IX4 ADP 0.000002002 0.40767 29.1262
45 2CSN CKI 0.0005368 0.41968 29.2929
46 4EUU BX7 0.0000001496 0.4539 30.0971
47 4IDT T28 0.0000001099 0.41191 30.0971
48 4FL3 ANP 0.0000001855 0.44123 30.4207
49 3KRL KRL 0.00000006225 0.43821 30.4207
50 3PP0 03Q 0.000003177 0.55621 30.7443
51 5T8O 76Z 0.00000002015 0.68618 31.3916
52 5HCY 60D 0.00000004686 0.53039 31.3916
53 5JFS 6K0 0.0000004512 0.48797 31.8182
54 3UIM ANP 0.00000002056 0.43911 32.0388
55 4CLI 5P8 0.00000006432 0.52613 32.3625
56 4Y8D 49J 0.00000009127 0.42662 32.3625
57 5TA6 79D 0.000000003522 0.50147 32.6861
58 5UIU 8CG 0.0000002904 0.46231 32.6861
59 3FC2 IBI 0.00009409 0.45181 32.6861
60 2R5T ANP 0.0000001709 0.4428 32.6861
61 4U44 3D9 0.0000009658 0.40583 32.6861
62 4P5Z Q7M 0.0000005834 0.47978 33.0097
63 5LPZ ADP 0.000000001683 0.45504 33.0097
64 4OH4 ANP 0.000000004569 0.45094 33.0097
65 2X2M X2M 0.00000005768 0.4441 33.0097
66 1U59 STU 0.00000000789 0.44472 33.101
67 3NW7 LGV 0.000006555 0.46896 33.2248
68 4E93 GUI 0.00000000554 0.51789 33.3333
69 3LXK MI1 0.0000001707 0.46291 33.3333
70 4Y93 746 0.0000001407 0.45354 33.3333
71 3LXN MI1 0.00000003094 0.44754 33.3333
72 3TKI S25 0.000000002321 0.59173 33.657
73 1U5R ATP 0.000000001051 0.45756 33.657
74 2HY0 306 0.00000002361 0.41482 33.657
75 5NKB 8ZT 0.00000001822 0.58138 33.6601
76 1VJY 460 0.000000007559 0.51251 33.6634
77 5AX9 4KT 0.0000005378 0.41197 33.7662
78 2XVD AS6 0.00000001722 0.4942 33.7748
79 4AT3 LTI 0.00000192 0.43704 33.7793
80 5HES 032 0.0000009634 0.41491 33.8762
81 4GJ3 0XP 0.00000001916 0.5002 34.106
82 4YZN 4K5 0.000000000126 0.50824 34.1463
83 5U6C 7YS 0.00000001346 0.45995 34.3042
84 5HX8 66P 0.000000005617 0.4906 34.4371
85 5EOB 5QQ 0.0000003596 0.52131 34.6278
86 5MJA 7O3 0.0000001045 0.40614 34.7541
87 3EKK GS2 0.000000005399 0.53576 34.8534
88 3KRR DQX 0.0000001104 0.54803 34.9153
89 3BU5 ATP 0.0000000006732 0.46207 34.9673
90 2Y6O 1N1 0.00000003112 0.44829 35.0515
91 4X7Q 3YR 0.000000011 0.71584 35.2564
92 3V8S 0HD 0.000000002749 0.4364 35.2751
93 4XLI 1N1 0.00000003984 0.41655 35.4478
94 5TO8 7FM 0.00000002424 0.52333 35.461
95 4F4P 0SB 0.0000000215 0.56692 35.5311
96 2WQN ADP 0.0000004044 0.66494 35.5987
97 2GU8 796 0.000000003159 0.59035 35.5987
98 1RE8 BD2 0.000000001176 0.58758 35.5987
99 4QMN DB8 0.0000000003618 0.5634 35.5987
100 3IDB ANP 0.000000009409 0.46898 35.5987
101 2QCS ANP 0.0000002056 0.45549 35.5987
102 3FHI ANP 0.0000002083 0.45329 35.5987
103 4E1Z 0MX 0.0000002075 0.43927 35.7388
104 4N70 2HX 0.0000000004513 0.60823 35.9223
105 2PZI AXX 0.0000532 0.55577 35.9223
106 3CY2 MB9 0.000000001966 0.47937 35.9223
107 4WB7 ATP 0.000003364 0.45074 35.9223
108 3PLS ANP 0.0000000004303 0.45831 36.2416
109 4WB6 ATP 0.0000002465 0.45257 36.246
110 4K33 ACP 0.0000001806 0.4252 36.246
111 4U0I 0LI 0.00004195 0.40517 36.246
112 3RI1 3RH 0.000000005464 0.49154 36.5696
113 1Y57 MPZ 0.00000001154 0.46811 36.5696
114 2PVF ACP 0.00000000628 0.43661 36.5696
115 2H8H H8H 0.0000007202 0.40366 36.5696
116 5USZ SKE 0.0000001629 0.46296 36.6782
117 3SLS ANP 0.0000009181 0.4233 36.8421
118 5JKG 6LF 0.000004369 0.45398 36.8932
119 1OPK P16 0.000009287 0.42396 36.8932
120 4EWH T77 0.00000009005 0.4684 37.0909
121 1BYG STU 0.00000001818 0.42284 37.4101
122 5LI1 ANP 0.0000001733 0.43806 37.5405
123 5MY8 RXZ 0.0000005448 0.43629 37.5405
124 4A4X JUP 0.0000001699 0.45508 37.6344
125 4OTH DRN 0.000000005209 0.46624 37.8641
126 3FHR P4O 0.000002405 0.59595 38.1877
127 5UR1 YY9 0.0000003776 0.49952 38.1877
128 3GNI ATP 0.0000001073 0.43025 38.1877
129 3GQI ACP 0.00000005833 0.42832 38.1877
130 2A19 ANP 0.000000004722 0.77602 38.3803
131 3E8N ATP 0.001628 0.42404 38.5113
132 3E8N VRA 0.001628 0.42404 38.5113
133 4AG8 AXI 0.000006673 0.50898 38.835
134 2Z7R STU 0.0000000001557 0.50126 38.835
135 3ORK AGS 0.000002927 0.42796 38.835
136 4ASE AV9 0.00001294 0.40645 38.835
137 3SRV S19 0.000000001745 0.44691 38.9892
138 4RFM 3P6 0.000039 0.44896 39.0977
139 5FBN 5WF 0.000003004 0.45152 39.1144
140 3M2W L8I 0.00000003666 0.41102 39.1304
141 4NW6 2NS 0.00000001363 0.50738 39.1586
142 4I6H 1C8 0.0000001485 0.4204 39.2857
143 3G5D 1N1 0.00000002171 0.56276 39.5105
144 5VCV 1N1 0.000000009121 0.47547 39.8058
145 5C03 AGS 0.0000006583 0.40621 39.8058
146 4WNP 3RJ 0.0000000001896 0.44341 40.4181
147 4XV1 904 0.0000001311 0.48252 40.7534
148 5N87 N66 0.000000006396 0.52733 41.1003
149 4M69 ANP 0.0000006253 0.42579 41.2141
150 3BZ3 YAM 0.0000009616 0.47711 41.3043
151 3VRY B43 0.000005162 0.55219 41.4239
152 3HMO STU 0.0000000001025 0.46224 41.4239
153 4YZC STU 0.00000004004 0.50997 41.7476
154 3ALN ANP 0.0000002952 0.42901 41.7476
155 4BHN BH9 0.0000003679 0.41911 41.7476
156 4TWP AXI 0.000001776 0.48305 42.0664
157 5IH9 6BF 0.00000001575 0.51769 42.0712
158 3QCQ 3Q0 0.000000005753 0.61127 42.3948
159 5LVP ATP 0.000000008808 0.4219 42.7184
160 3KN5 ANP 0.00000003031 0.41445 42.7184
161 4CQE CQE 0.0000004662 0.41983 42.8058
162 2OFV 242 0.0000006805 0.46993 42.9603
163 4JR7 GNP 0.000000007546 0.44411 43.0421
164 2V7O DRN 0.000000000368 0.41985 43.0421
165 2VZ6 FEF 0.000001053 0.64352 43.3657
166 4D2S DYK 0.000000004329 0.42114 43.662
167 5LI9 ACP 0.00000001332 0.70298 43.6893
168 3PVW QRX 0.00000007056 0.62659 43.6893
169 3MVH WFE 0.00000002454 0.48757 43.6893
170 4BFM ANP 0.000000002073 0.47323 43.6893
171 4JDI ANP 0.0000001825 0.43144 43.6893
172 4FG8 ATP 0.0000005632 0.4215 43.6893
173 5UKL SIX 0.000006302 0.42135 43.6893
174 5JZJ AN2 0.00000007252 0.42317 44.1077
175 4WNK 453 0.0000003638 0.46457 44.3366
176 2VN9 GVD 0.00000000213 0.40932 44.8505
177 2JDR L20 0.00000000289 0.59309 44.9838
178 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.00000000289 0.59309 44.9838
179 1XJD STU 0.000000004409 0.45614 44.9838
180 2X4Z X4Z 0.0000001689 0.48589 45.6081
181 4F9C 0SX 0.0000002628 0.40437 45.6311
182 5DRB 5FJ 0.00001232 0.4601 46.3918
183 3GGF GVD 0.00000007342 0.41481 46.5116
184 1Q8Y ADP 0.00000004828 0.44621 46.6019
185 3DAK ANP 0.0000001083 0.41124 46.8966
186 4KS7 X4Z 0.00000001711 0.67389 46.9178
187 3C0G 3AM 0.000000002041 0.42465 46.9256
188 1PHK ATP 0.0000000007347 0.47712 46.9799
189 5UOX 8GY 0.00000005953 0.44175 47.2325
190 4L3L 5FI 0.00000001259 0.49735 47.3684
191 2HK5 1BM 0.00000001352 0.45014 47.4074
192 3IGO ANP 0.000000147 0.63886 47.5728
193 5X8I SQZ 0.0000000006011 0.46947 47.5728
194 3SXF BK5 0.00003014 0.4224 47.5728
195 2WU6 DKI 0.000000000448 0.50326 47.8964
196 5JGA 6KC 0.0000000929 0.48049 47.8964
197 4IJP 1EH 0.000000001372 0.47236 48.2201
198 2YAB AMP 0.00000002327 0.44606 48.2201
199 3SXS PP2 0.000001047 0.40905 48.5075
200 5DH3 5BS 0.000001089 0.40816 48.5437
201 4YLL 4E3 0.00000001794 0.47049 48.8673
202 3TXO 07U 0.00000007987 0.41573 48.8673
203 5DEY 59T 0.0000005007 0.51532 49.1582
204 3OFM 4B0 0.00000001247 0.41866 49.1909
205 2ZV2 609 0.0000002403 0.6861 49.3289
206 4C2V YJA 0.0000001602 0.47129 49.4737
207 2YAK OSV 0.0000000004132 0.53607 49.8246
208 3PE2 E1B 0.00000005704 0.53431 49.8382
Pocket No.: 2; Query (leader) PDB : 2BPM; Ligand: 529; Similar sites found: 3
This union binding pocket(no: 2) in the query (biounit: 2bpm.bio2) has 53 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3SHR CMP 0.01835 0.43324 8.3612
2 2HKA C3S 0.03323 0.40367 10.7692
3 4KU7 PCG 0.04696 0.4078 15.6863
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