Receptor
PDB id Resolution Class Description Source Keywords
4H5E 2.04 Å EC: 2.5.1.10 CRYSTAL STRUCTURE OF HUMAN FPPS IN TERNARY COMPLEX WITH YS04 ISOPENTENYL PYROPHOSPHATE HOMO SAPIENS TRANSFERASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: TERNARY COMPLEX STRUCTURES OF HUMAN FARNESYL PYROPH SYNTHASE BOUND WITH A NOVEL INHIBITOR AND SECONDARY PROVIDE INSIGHTS INTO THE MOLECULAR DETAILS OF THE ACTIVE SITE CLOSURE. BMC STRUCT.BIOL. V. 12 32 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
IPR F:402;
Valid;
none;
submit data
248.108 C5 H14 O7 P2 CC(C)...
MG F:403;
F:404;
F:405;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
YS4 F:401;
Valid;
none;
Kd = 0.86 uM
402.276 C15 H20 N2 O7 P2 CC(C)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4DEM 1.85 Å EC: 2.5.1.10 CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH YS_04_70 HOMO SAPIENS MEVALONATE PATHWAY ISOPRENE BIOSYNTHESIS CHOLESTEROL BIOSYBISPHOSPHONATE TRANSFERASE TRANSFERASE-TRANSFERASE INHIBICOMPLEX
Ref.: DESIGN AND SYNTHESIS OF ACTIVE SITE INHIBITORS OF T FARNESYL PYROPHOSPHATE SYNTHASE: APOPTOSIS AND INHI ERK PHOSPHORYLATION IN MULTIPLE MYELOMA CELLS. J.MED.CHEM. V. 55 3201 2012
Members (33)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 1ZW5 - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
2 1YV5 - RIS C7 H11 N O7 P2 c1cc(cnc1)....
3 4QXS ic50 = 1.1 uM WC1 C21 H27 N O6 P2 C[C@H](c1c....
4 4P0V - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
5 2F92 - AHD C4 H9 N O7 P2 C(CC(O)(P(....
6 5JUZ ic50 = 3 uM YL4 C22 H20 N3 O4 P S Cc1ccc(cc1....
7 4RXA ic50 = 1.8 uM 3F2 C32 H28 N6 O2 c1cc(cc(c1....
8 3N49 ic50 = 7 uM 3N4 C14 H10 O2 S c1ccc2c(c1....
9 5JV2 ic50 = 100 uM 6O3 C14 H13 N2 O3 P S Cc1ccc(cc1....
10 3N5J ic50 = 8 uM GO1 C11 H7 Cl2 N O4 c1c(cc(c2c....
11 2F9K - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
12 3N45 - PO4 O4 P [O-]P(=O)(....
13 4LPH ic50 = 4.5 uM YL3 C14 H14 N3 O3 P S Cc1ccc(cc1....
14 5JV1 ic50 = 0.86 uM YL6 C21 H18 Cl F N3 O3 P S Cc1ccc(cc1....
15 4LFV - YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
16 4LPG ic50 = 0.022 uM 1MV C14 H15 N3 O6 P2 S Cc1ccc(cc1....
17 2F94 - BFQ C9 H23 N O7 P2 CCCCC[N@](....
18 3N6K ic50 = 0.2 uM BFH C15 H11 N O4 c1ccc2c(c1....
19 5JV0 ic50 = 1.1 uM YL5 C21 H19 F N3 O3 P S Cc1ccc(cc1....
20 4H5E Kd = 0.86 uM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
21 3N5H ic50 = 2 uM GO0 C11 H7 Cl2 N O4 c1cc(c2c(c....
22 4H5D Kd = 0.58 uM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
23 2F8C - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
24 4P0W - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
25 3N46 - PO4 O4 P [O-]P(=O)(....
26 4P0X - 1WO C20 H26 O3 CC(C)C1=CC....
27 4H5C - PO4 O4 P [O-]P(=O)(....
28 5DGN ic50 = 1.2 uM 59Y C20 H13 N O2 c1ccc2c(c1....
29 4DEM ic50 = 28 nM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
30 3N1V ic50 > 500 uM 3N1 C11 H9 Cl O2 S Cc1c2cc(cc....
31 2OPM - NI9 C7 H11 F N O7 P2 c1cc(c[n+]....
32 5JA0 Kd = 5.3 uM FPP C15 H28 O7 P2 CC(=CCC/C(....
33 1YQ7 - RIS C7 H11 N O7 P2 c1cc(cnc1)....
70% Homology Family (36)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 7 families.
1 1ZW5 - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
2 1YV5 - RIS C7 H11 N O7 P2 c1cc(cnc1)....
3 4QXS ic50 = 1.1 uM WC1 C21 H27 N O6 P2 C[C@H](c1c....
4 4P0V - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
5 2F92 - AHD C4 H9 N O7 P2 C(CC(O)(P(....
6 5JUZ ic50 = 3 uM YL4 C22 H20 N3 O4 P S Cc1ccc(cc1....
7 4RXA ic50 = 1.8 uM 3F2 C32 H28 N6 O2 c1cc(cc(c1....
8 3N49 ic50 = 7 uM 3N4 C14 H10 O2 S c1ccc2c(c1....
9 5JV2 ic50 = 100 uM 6O3 C14 H13 N2 O3 P S Cc1ccc(cc1....
10 3N5J ic50 = 8 uM GO1 C11 H7 Cl2 N O4 c1c(cc(c2c....
11 2F9K - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
12 3N45 - PO4 O4 P [O-]P(=O)(....
13 4LPH ic50 = 4.5 uM YL3 C14 H14 N3 O3 P S Cc1ccc(cc1....
14 5JV1 ic50 = 0.86 uM YL6 C21 H18 Cl F N3 O3 P S Cc1ccc(cc1....
15 4LFV - YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
16 4LPG ic50 = 0.022 uM 1MV C14 H15 N3 O6 P2 S Cc1ccc(cc1....
17 2F94 - BFQ C9 H23 N O7 P2 CCCCC[N@](....
18 3N6K ic50 = 0.2 uM BFH C15 H11 N O4 c1ccc2c(c1....
19 5JV0 ic50 = 1.1 uM YL5 C21 H19 F N3 O3 P S Cc1ccc(cc1....
20 4H5E Kd = 0.86 uM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
21 3N5H ic50 = 2 uM GO0 C11 H7 Cl2 N O4 c1cc(c2c(c....
22 4H5D Kd = 0.58 uM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
23 2F8C - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
24 4P0W - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
25 3N46 - PO4 O4 P [O-]P(=O)(....
26 4P0X - 1WO C20 H26 O3 CC(C)C1=CC....
27 4H5C - PO4 O4 P [O-]P(=O)(....
28 5DGN ic50 = 1.2 uM 59Y C20 H13 N O2 c1ccc2c(c1....
29 4DEM ic50 = 28 nM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
30 3N1V ic50 > 500 uM 3N1 C11 H9 Cl O2 S Cc1c2cc(cc....
31 2OPM - NI9 C7 H11 F N O7 P2 c1cc(c[n+]....
32 5JA0 Kd = 5.3 uM FPP C15 H28 O7 P2 CC(=CCC/C(....
33 1YQ7 - RIS C7 H11 N O7 P2 c1cc(cnc1)....
34 1UBY - DMA C5 H12 O7 P2 CC(=CCO[P@....
35 1UBX - FPP C15 H28 O7 P2 CC(=CCC/C(....
36 1UBW - GPP C10 H20 O7 P2 CC(=CCC/C(....
50% Homology Family (63)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1ZW5 - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
2 1YV5 - RIS C7 H11 N O7 P2 c1cc(cnc1)....
3 4QXS ic50 = 1.1 uM WC1 C21 H27 N O6 P2 C[C@H](c1c....
4 4P0V - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
5 2F92 - AHD C4 H9 N O7 P2 C(CC(O)(P(....
6 5JUZ ic50 = 3 uM YL4 C22 H20 N3 O4 P S Cc1ccc(cc1....
7 4RXA ic50 = 1.8 uM 3F2 C32 H28 N6 O2 c1cc(cc(c1....
8 3N49 ic50 = 7 uM 3N4 C14 H10 O2 S c1ccc2c(c1....
9 5JV2 ic50 = 100 uM 6O3 C14 H13 N2 O3 P S Cc1ccc(cc1....
10 3N5J ic50 = 8 uM GO1 C11 H7 Cl2 N O4 c1c(cc(c2c....
11 2F9K - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
12 3N45 - PO4 O4 P [O-]P(=O)(....
13 4LPH ic50 = 4.5 uM YL3 C14 H14 N3 O3 P S Cc1ccc(cc1....
14 5JV1 ic50 = 0.86 uM YL6 C21 H18 Cl F N3 O3 P S Cc1ccc(cc1....
15 4LFV - YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
16 4LPG ic50 = 0.022 uM 1MV C14 H15 N3 O6 P2 S Cc1ccc(cc1....
17 2F94 - BFQ C9 H23 N O7 P2 CCCCC[N@](....
18 3N6K ic50 = 0.2 uM BFH C15 H11 N O4 c1ccc2c(c1....
19 5JV0 ic50 = 1.1 uM YL5 C21 H19 F N3 O3 P S Cc1ccc(cc1....
20 4H5E Kd = 0.86 uM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
21 3N5H ic50 = 2 uM GO0 C11 H7 Cl2 N O4 c1cc(c2c(c....
22 4H5D Kd = 0.58 uM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
23 2F8C - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
24 4P0W - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
25 3N46 - PO4 O4 P [O-]P(=O)(....
26 4P0X - 1WO C20 H26 O3 CC(C)C1=CC....
27 4H5C - PO4 O4 P [O-]P(=O)(....
28 5DGN ic50 = 1.2 uM 59Y C20 H13 N O2 c1ccc2c(c1....
29 4DEM ic50 = 28 nM YS4 C15 H20 N2 O7 P2 CC(C)Oc1cc....
30 3N1V ic50 > 500 uM 3N1 C11 H9 Cl O2 S Cc1c2cc(cc....
31 2OPM - NI9 C7 H11 F N O7 P2 c1cc(c[n+]....
32 5JA0 Kd = 5.3 uM FPP C15 H28 O7 P2 CC(=CCC/C(....
33 1YQ7 - RIS C7 H11 N O7 P2 c1cc(cnc1)....
34 2O1O Ki = 0.38 nM RIS C7 H11 N O7 P2 c1cc(cnc1)....
35 2Q58 - ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
36 3LDW Ki = 10.7 nM ZOL C5 H10 N2 O7 P2 c1cn(cn1)C....
37 3PH7 - GRG C20 H36 O7 P2 CC(=CCC/C(....
38 5HN7 ic50 = 120 uM 04M C26 H35 N O7 S CCCCCCCCOc....
39 5HN9 ic50 = 50 uM 04W C24 H31 N O6 CCCCCCCCCC....
40 1UBY - DMA C5 H12 O7 P2 CC(=CCO[P@....
41 1UBX - FPP C15 H28 O7 P2 CC(=CCC/C(....
42 1UBW - GPP C10 H20 O7 P2 CC(=CCC/C(....
43 4K10 Kd = 119.5 nM NI9 C7 H11 F N O7 P2 c1cc(c[n+]....
44 4RXE ic50 = 230 nM 3YQ C7 H12 N2 O6 P2 Cc1cccnc1N....
45 2EWG - M0N C9 H12 N2 O7 P2 c1ccn2c(c1....
46 5AFX ic50 = 1.2 uM PVZ C14 H29 N2 O7 P2 CCCCCCCCCn....
47 3DYH - 721 C11 H20 N O7 P2 CCCCOc1ccc....
48 2I19 - 1BY C7 H12 N2 O6 P2 c1ccnc(c1)....
49 3EGT Ki = 32 nM 722 C14 H26 N O7 P2 CCCCCCCOc1....
50 3EFQ - 714 C15 H28 N O7 P2 CCCCCCCCOc....
51 4RXD ic50 = 300 nM RIS C7 H11 N O7 P2 c1cc(cnc1)....
52 4RXC ic50 ~ 33 uM HRX C8 H13 N O7 P2 c1cc(cnc1)....
53 3DYG - NI9 C7 H11 F N O7 P2 c1cc(c[n+]....
54 2P1C Ki = 21 nM GG3 C14 H25 N O7 P2 C[N@](CCCC....
55 4DXJ ic50 = 38 nM 0M9 C5 H15 N O6 P2 CCCNCC(P(=....
56 3ICN - NI9 C7 H11 F N O7 P2 c1cc(c[n+]....
57 3ICK - IPR C5 H14 O7 P2 CC(C)CCO[P....
58 4DWB ic50 = 1.84 uM 0M7 C7 H19 N O6 P2 CCCCCNCC(P....
59 4DWG ic50 = 58 nM 0M8 C9 H23 N O6 P2 CCCCCCCNCC....
60 3ICM - P2H C13 H16 N O7 P2 c1ccc(cc1)....
61 3ICZ - PB6 C11 H18 N O6 P2 CC/C=C/c1c....
62 1YHL - RIS C7 H11 N O7 P2 c1cc(cnc1)....
63 3IBA - SO4 O4 S [O-]S(=O)(....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: IPR; Similar ligands found: 19
No: Ligand ECFP6 Tc MDL keys Tc
1 IPR 1 1
2 IS3 0.666667 0.918919
3 EIP 0.631579 0.864865
4 P23 0.542857 0.885714
5 DED 0.5 0.772727
6 IPE 0.475 0.820513
7 P25 0.475 0.842105
8 P22 0.457143 0.771429
9 BHI 0.454545 0.780488
10 0CH 0.45 0.74359
11 43W 0.45 0.805556
12 0CJ 0.44186 0.842105
13 0JX 0.439024 0.828571
14 0K2 0.428571 0.805556
15 DST 0.425 0.837838
16 0O3 0.418605 0.707317
17 DP6 0.416667 0.8
18 0CM 0.414634 0.777778
19 3E9 0.413793 0.829268
Ligand no: 2; Ligand: YS4; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 YS4 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4DEM; Ligand: YS4; Similar sites found: 234
This union binding pocket(no: 1) in the query (biounit: 4dem.bio1) has 76 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1UO5 PIH 0.000598 0.57465 None
2 4F4S EFO 0.00007092 0.55648 None
3 3RF4 FUN 0.002101 0.48472 None
4 1G8S MET 0.01741 0.44949 0.869565
5 3NFZ 3NF 0.04423 0.40908 1.22324
6 1ULE GLA GAL NAG 0.00583 0.48737 1.33333
7 4JWX 1N4 0.02451 0.43248 1.42857
8 4E28 9MZ 0.002726 0.49132 1.53846
9 4E28 0MZ 0.004027 0.47651 1.53846
10 1HKU NAD 0.001594 0.42187 1.6
11 2BII MTV 0.02004 0.40098 1.6
12 3H9E NAD 0.01247 0.40132 1.7341
13 3LTW HLZ 0.001186 0.51003 1.78571
14 4KOA NDP 0.02307 0.41217 1.8018
15 2YP9 SIA CMO 0.02697 0.4108 1.86667
16 4M51 BEZ 0.006241 0.48573 1.87354
17 1A5Z OXM 0.03862 0.4416 1.88088
18 3OCZ SRA 0.002638 0.45177 1.9084
19 1UF5 CDT 0.00249 0.47053 1.9802
20 4B9E FAH 0.01021 0.46744 1.99336
21 2WA4 069 0.01295 0.4334 2.00573
22 4ASJ N6A 0.002312 0.43632 2.04778
23 1XVA SAM 0.02809 0.40293 2.05479
24 2QV7 ADP 0.01867 0.41925 2.07715
25 3QDT A2G GAL 0.002778 0.50519 2.0979
26 3QUR FM4 0.0063 0.40229 2.0979
27 3QUR ADP 0.0063 0.40229 2.0979
28 2Z9V PXM 0.0038 0.47216 2.13333
29 4RPM HXC 0.02938 0.46914 2.13333
30 4P53 NAI 0.002094 0.42594 2.13333
31 3WAS BGC BMA 0.001093 0.42459 2.13333
32 2Q09 DI6 0.0336 0.42174 2.13333
33 5AYC BGC BMA 0.01843 0.40112 2.13333
34 3HB5 NAP 0.000008971 0.44162 2.14067
35 3HB5 E2B 0.002598 0.43132 2.14067
36 3P9C SAH 0.001629 0.41901 2.1978
37 2JGS BTN 0.02997 0.43028 2.30769
38 1FW1 GSH 0.006876 0.44178 2.31481
39 4DEC UDP 0.002055 0.42907 2.32558
40 4DEC 3PG 0.002055 0.42907 2.32558
41 2F2U M77 0.002167 0.47332 2.4
42 4RJK PYR 0.02602 0.45123 2.4
43 1QDS PGA 0.0161 0.43297 2.4
44 1Y42 TYR 0.02709 0.43033 2.4
45 4RJK TDL 0.005388 0.40683 2.4
46 2R5T ANP 0.005238 0.42906 2.41287
47 1RHC F42 ACN 0.003893 0.41155 2.42424
48 1UNB AKG 0.0004978 0.40992 2.57235
49 1I2L DCS 0.004942 0.43332 2.60223
50 1XIU REA 0.00258 0.45217 2.6087
51 1TUV VK3 0.02095 0.46296 2.63158
52 4KCT PYR 0.005157 0.46063 2.66667
53 3QV9 QV7 0.02987 0.43256 2.66667
54 1RM0 D6P 0.00005973 0.42144 2.66667
55 1E5F PLP 0.0183 0.41964 2.66667
56 4KCT FDP 0.02625 0.41946 2.66667
57 1RM0 NAI 0.0003687 0.40808 2.66667
58 3SHR CMP 0.01106 0.44054 2.67559
59 4P4T GDP 0.006896 0.43081 2.77778
60 1PEA ACM 0.0131 0.46785 2.85714
61 3QXG TLA 0.02707 0.40358 2.88066
62 1DBT U5P 0.008263 0.42759 2.92887
63 4LHM AZZ 0.001015 0.50656 2.93333
64 1WDA BAG 0.004286 0.46445 2.93333
65 4L1F COS 0.001138 0.44789 2.93333
66 2Q28 ADP 0.007079 0.42706 2.93333
67 3A1I UNU 0.02333 0.42545 2.93333
68 4PNI KQQ 0.006116 0.41762 2.93333
69 2ORV 4TA 0.001979 0.43567 2.99145
70 2EB5 OXL 0.01126 0.45935 2.99625
71 2Q1W NAD 0.002186 0.4149 3.003
72 4IMG NGF 0.01398 0.41518 3.07167
73 2BH9 NAP 0.01705 0.42095 3.2
74 1B4P GPS 0.01896 0.41274 3.22581
75 2RH4 EMO 0.0001328 0.4195 3.2491
76 3GX0 GDS 0.004511 0.43491 3.25581
77 4Q0A GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 0.01099 0.4225 3.31126
78 4Q0A 4OA 0.02489 0.40785 3.31126
79 4FFS BIG 0.01668 0.404 3.34728
80 3KMT SAH 0.01214 0.43089 3.36134
81 1XE7 GUN 0.004686 0.50042 3.44828
82 4L6C 0BT 0.00344 0.43296 3.46535
83 4QCK ASD 0.01009 0.40704 3.46667
84 1QZZ SAM 0.007771 0.43944 3.47594
85 1LOR BMP 0.008226 0.40295 3.50877
86 4OB6 S2T 0.01477 0.42366 3.51906
87 4IXW IXW 0.02016 0.4324 3.54331
88 1Z41 FMN 0.001215 0.47024 3.5503
89 1Z44 FMN 0.003548 0.45442 3.5503
90 2QTR NXX 0.005321 0.4047 3.7037
91 2Q8H TF4 0.0005546 0.55357 3.73333
92 2C5S AMP 0.0247 0.42817 3.73333
93 1T10 F6P 0.03965 0.42627 3.73333
94 1VL8 NAP 0.001724 0.41576 3.74532
95 4K30 NLG 0.02323 0.43363 3.75
96 1MZV AMP 0.007956 0.44718 3.82979
97 1B63 ANP 0.01224 0.41176 3.9039
98 1V6A TRE 0.02969 0.43269 3.91566
99 2PVQ GSH 0.006219 0.43615 3.9801
100 2IZ1 ATR 0.003501 0.48569 4
101 2NU8 COA 0.0005728 0.4115 4
102 1F1V DHY 0.0006692 0.50272 4.02477
103 2FR6 URI 0.0119 0.42108 4.10959
104 2FR6 CTN 0.02626 0.40689 4.10959
105 1KTC NGA 0.004237 0.46985 4.19753
106 4OHB 5HM 0.01888 0.41905 4.21053
107 1GEE NAD 0.0005495 0.43703 4.21456
108 1NJR XYL 0.0009606 0.43768 4.22535
109 1Q11 TYE 0.005803 0.46317 4.30108
110 2QQ0 ADP 0.001486 0.42287 4.34783
111 2QQ0 TMP 0.001486 0.42287 4.34783
112 2QQ0 THM 0.002785 0.41899 4.34783
113 2QQ0 ANP 0.002395 0.41607 4.34783
114 1YOA FMN 0.002297 0.5383 4.40252
115 1YOA FAD 0.001434 0.44754 4.40252
116 2Q37 3AL 0.006753 0.46521 4.41989
117 1I0Z OXM 0.000774 0.54527 4.5045
118 4M5P 23W 0.005955 0.48686 4.53333
119 4M5P MLA 0.04723 0.44881 4.53333
120 3DGB MUC 0.008076 0.44267 4.53333
121 2PP3 LGT 0.02106 0.42031 4.53333
122 4M5P FMN 0.02213 0.40442 4.53333
123 1ZZ7 S0H 0.02107 0.43571 4.54545
124 1CKM GTP 0.01496 0.41399 4.54545
125 3IPQ 965 0.0001839 0.45582 4.59364
126 2C2A ADP 0.00009869 0.5115 4.65116
127 3E8N ATP 0.0002236 0.42039 4.69208
128 3E8N VRA 0.0002236 0.42039 4.69208
129 4PTZ FMN 0.005541 0.43825 4.71204
130 2YGO PCF 0.000662 0.44022 4.78723
131 1O0S NAI 0.002537 0.4348 4.8
132 3I8P 840 0.02997 0.41034 4.8
133 1TV5 N8E 0.02352 0.40887 4.8
134 1TV5 ORO 0.04582 0.40087 4.8
135 1ZJ6 G3D 0.01032 0.43786 4.81283
136 2GJN NIS 0.00769 0.40632 4.87805
137 2GJN FMN 0.01474 0.40107 4.87805
138 2JBH 5GP 0.01365 0.4405 4.88889
139 2WL9 MBD 0.01199 0.40683 4.91803
140 2OFE NAG 0.03424 0.43411 4.92958
141 2NCD ADP 0.004626 0.47348 5.06667
142 1TFZ 869 0.005272 0.4322 5.06667
143 3A2Y TS5 0.02163 0.41335 5.07614
144 1I52 CTP 0.004599 0.40913 5.08475
145 1W7J ADP BEF 0.001858 0.45814 5.29801
146 2PR5 FMN 0.01046 0.42337 5.30303
147 2RL1 UD1 0.005792 0.41576 5.33333
148 3JQ3 ADP 0.009646 0.4433 5.46448
149 3MAG 3MA 0.01018 0.48899 5.53746
150 3MAG SAH 0.008525 0.42382 5.53746
151 1K6M AGS 0.005531 0.42504 5.6
152 2O2C G6Q 0.01794 0.42 5.6
153 4Q3S X7A 0.01214 0.40413 5.6
154 2YCD GTB 0.01442 0.43128 5.65217
155 1BTN I3P 0.002236 0.53426 5.66038
156 1Y9Q MED 0.01889 0.44765 5.72917
157 1A8S PPI 0.03572 0.41504 5.86667
158 3I0O SMI 0.003302 0.48084 5.8997
159 3I0O ADP 0.02025 0.42833 5.8997
160 1W3R PYR 0.006994 0.48299 6.01852
161 3M31 FAD 0.004646 0.42493 6.13333
162 1B7Y FYA 0.001168 0.44086 6.4
163 3PLN U5P 0.02206 0.43473 6.4
164 1SQ5 PAU 0.004147 0.4703 6.49351
165 1SQ5 ADP 0.03224 0.41538 6.49351
166 2O4J VD4 0.003683 0.4201 6.50685
167 1SJD NPG 0.000484 0.45817 6.52174
168 1SZD APR 0.0007932 0.42133 6.73401
169 2Y7G AAE 0.02534 0.41351 6.73759
170 1RZM E4P 0.02347 0.44797 6.80473
171 1RZM PEP 0.04828 0.41786 6.80473
172 3NOJ PYR 0.02868 0.43124 7.14286
173 3P7I P7I 0.02558 0.43156 7.16511
174 3CF6 SP1 0.01535 0.42293 7.18563
175 2QCX PF1 0.0002598 0.53627 7.2
176 1P1M MET 0.0033 0.43366 7.2
177 1EJE FMN 0.001 0.46516 7.29167
178 1L8N GCW 0.01268 0.40849 7.46667
179 1F3L SAH 0.007064 0.42096 7.47664
180 3UEC ALA ARG TPO LYS 0.01278 0.4622 7.53425
181 3DER ALA LYS 0.009027 0.41978 7.53623
182 1QO0 BMD 0.006934 0.4703 7.65306
183 4COQ SAN 0.005707 0.47468 7.69231
184 2AHR NAP 0.0009791 0.42881 7.72201
185 3BY8 MLT 0.008951 0.47051 7.74648
186 1HDG NAD 0.007154 0.41245 7.83133
187 1IIM TTP 0.0002521 0.43117 7.87671
188 2V5E SCR 0.02755 0.46302 7.92079
189 4L7I SAM 0.01511 0.41993 8
190 1WKL ADP 0.03372 0.40238 8.0292
191 3F81 STT 0.02041 0.46361 8.19672
192 2Y7P SAL 0.01296 0.44608 8.25688
193 1O9U ADZ 0.0007308 0.5467 8.28571
194 2QLX RM4 0.04154 0.43452 8.33333
195 2A2X NA9 0.009741 0.42465 8.82353
196 1ZS6 ADP 0.006337 0.45637 8.87574
197 2CJE DUN 0.002014 0.44894 8.95522
198 1FX8 BOG 0.01869 0.41604 9.60854
199 2WGC SIA GAL BGC 0.04285 0.45877 9.94152
200 1WGC SIA GAL BGC 0.0362 0.45583 9.94152
201 2XDQ MGX 0.01068 0.47984 10.1333
202 3ZPG 5GP 0.04015 0.44653 10.1333
203 1OYB FMN 0.002042 0.43835 10.1333
204 1OYB HBA 0.003988 0.41888 10.1333
205 1QD0 RR6 0.006664 0.44644 10.1562
206 2FH5 GTP 0.01005 0.42096 10.7477
207 4M4Q 21A 0.002914 0.42948 10.7884
208 1C1L GAL BGC 0.02084 0.45076 10.9489
209 2WMO GTP 0.003808 0.45307 11.0526
210 4ORR PE3 0.001348 0.43862 11.0526
211 1EB9 HBA 0.009136 0.44025 11.8321
212 1IG3 VIB 0.003709 0.41226 12.1673
213 1SS4 GSH 0.000353 0.59728 12.4183
214 1SS4 CIT 0.0006628 0.58556 12.4183
215 3CIP ATP 0.001209 0.40057 12.5
216 2RHQ GAX 0.01186 0.4123 12.585
217 2EJU SAH 0.011 0.42248 13.3333
218 2IMF TOM 0.006495 0.41666 13.7931
219 2IMF GSH 0.006495 0.41666 13.7931
220 1N9L FMN 0.001168 0.4624 14.6789
221 1LNX URI 0.002856 0.47822 14.8148
222 1VF1 GSH 0.008362 0.42737 14.8472
223 1MXI SAH 0.01261 0.42004 15
224 1T0S BML 0.004195 0.49529 15.1163
225 2IYG FMN 0.0005591 0.49492 15.3226
226 1V7R CIT 0.00328 0.51839 15.5914
227 1ECM TSA 0.008646 0.44995 15.5963
228 1YRX FMN 0.00199 0.46546 15.7025
229 1VE3 SAM 0.003207 0.44445 17.1806
230 3S9K CIT 0.005473 0.50711 17.7966
231 2E1A MSE 0.01614 0.43702 18.6667
232 1XX4 BAM 0.01922 0.43994 19.9234
233 1NYT NAP 0.002925 0.42648 20.6642
234 2FYU FDN 0.006881 0.43085 32.2581
Feedback