Receptor
PDB id Resolution Class Description Source Keywords
4I67 2.33 Å EC: 3.6.4.13 CRYSTAL STRUCTURE OF THE RRM DOMAIN OF RNA HELICASE HERA FRO THERMOPHILUS IN COMPLEX WITH GGGC RNA THERMUS THERMOPHILUS UNWINDING ATPASE HEAT RESISTANT RNA RECOGNITION MOTIF RNBINDING DEAD BOX PROTEIN HYDROLASE-RNA COMPLEX
Ref.: RECOGNITION OF TWO DISTINCT ELEMENTS IN THE RNA SUB THE RNA-BINDING DOMAIN OF THE T. THERMOPHILUS DEAD HELICASE HERA. NUCLEIC ACIDS RES. V. 41 6259 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
G G G RPC B:1;
Valid;
none;
submit data
1431.74 n/a [P+](...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4I67 2.33 Å EC: 3.6.4.13 CRYSTAL STRUCTURE OF THE RRM DOMAIN OF RNA HELICASE HERA FRO THERMOPHILUS IN COMPLEX WITH GGGC RNA THERMUS THERMOPHILUS UNWINDING ATPASE HEAT RESISTANT RNA RECOGNITION MOTIF RNBINDING DEAD BOX PROTEIN HYDROLASE-RNA COMPLEX
Ref.: RECOGNITION OF TWO DISTINCT ELEMENTS IN THE RNA SUB THE RNA-BINDING DOMAIN OF THE T. THERMOPHILUS DEAD HELICASE HERA. NUCLEIC ACIDS RES. V. 41 6259 2013
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 4I67 - G G G RPC n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 4I67 - G G G RPC n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 7 families.
1 4I67 - G G G RPC n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: G G G RPC; Similar ligands found: 87
No: Ligand ECFP6 Tc MDL keys Tc
1 G G G RPC 1 1
2 A G C C 0.882883 0.961538
3 G C C C 0.789916 0.949367
4 G G G C 0.762712 0.962025
5 G C 0.756522 0.949367
6 G G 0.697248 0.935897
7 OMC OMU OMG OMG U 0.611511 0.938272
8 U A G G 0.606299 0.935897
9 U A C C 0.596899 0.935897
10 CG2 0.595238 0.91358
11 U G A 0.592857 0.962025
12 G G U 0.586777 0.935897
13 A G U 0.574468 0.962025
14 APC G U 0.572519 0.935897
15 C C 0.567568 0.846154
16 G A A A 0.561538 0.924051
17 GPC 0.55303 0.880952
18 G3D 0.547826 0.886076
19 G4P 0.538462 0.886076
20 A U C C 0.524476 0.924051
21 CTP C C C C 0.519685 0.881579
22 DC DG 0.518797 0.914634
23 3GP 0.509091 0.897436
24 0O2 0.508197 0.886076
25 GDP MG 0.495726 0.876543
26 G U34 0.492537 0.9375
27 ALF 5GP 0.491525 0.845238
28 GDP BEF 0.491525 0.855422
29 GCP G 0.487603 0.8875
30 DG DC 0.485915 0.902439
31 U2G 0.485075 0.91358
32 GTP MG 0.479339 0.876543
33 BEF GDP 0.479339 0.845238
34 G 0.473684 0.886076
35 5GP 0.473684 0.886076
36 DC DG DA DC 0.473684 0.925926
37 UCG 0.472222 0.936709
38 GDP AF3 0.467742 0.845238
39 GDP ALF 0.467742 0.845238
40 GDP 0.466102 0.875
41 GNH 0.462185 0.864198
42 GPG 0.460317 0.888889
43 GSP 0.459016 0.833333
44 GP3 0.457627 0.9
45 CGP 0.456522 0.891566
46 2GP 0.45614 0.8625
47 GP2 0.453782 0.843373
48 GMP 0.453704 0.7875
49 U A A U 0.44898 0.911392
50 DA DC DG DA 0.446541 0.926829
51 GTP 0.442623 0.875
52 GMV 0.442623 0.853659
53 DC DG DT DA 0.440476 0.904762
54 DG DA DC DG 0.440252 0.926829
55 GAV 0.44 0.843373
56 G1R 0.439024 0.864198
57 GCP 0.439024 0.853659
58 U U U U 0.438017 0.807692
59 GDP 7MG 0.43609 0.9125
60 G2P 0.435484 0.843373
61 GNP 0.435484 0.853659
62 DT DA DC DG 0.434524 0.904762
63 G2R 0.429688 0.843373
64 DG DG 0.426357 0.890244
65 GKE 0.424242 0.865854
66 GDC 0.424242 0.865854
67 GDD 0.424242 0.865854
68 UTP U U U 0.422764 0.815789
69 JB2 0.422222 0.865854
70 BGO 0.421429 0.878049
71 C3P 0.418182 0.833333
72 6CK 0.41791 0.845238
73 Y9Z 0.413534 0.795455
74 CSQ 0.412214 0.783133
75 CSV 0.412214 0.783133
76 NGD 0.411348 0.9125
77 I2C FE2 CMO CMO 0.410959 0.831461
78 GDR 0.410448 0.865854
79 GFB 0.410448 0.865854
80 GDX 0.408759 0.876543
81 3PD UM3 0.408451 0.9375
82 YGP 0.406015 0.879518
83 A U 0.404255 0.898734
84 GGM 0.402778 0.857143
85 GKD 0.40146 0.865854
86 DA DU DG DA 0.401408 0.902439
87 GTG 0.4 0.890244
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4I67; Ligand: G G G RPC; Similar sites found: 134
This union binding pocket(no: 1) in the query (biounit: 4i67.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3WV1 WHH 0.005721 0.45174 None
2 3LLI FAD 0.003161 0.44815 None
3 4ORM ORO 0.01496 0.44412 None
4 4ORM 2V6 0.01496 0.44412 None
5 4ORM FMN 0.01496 0.44412 None
6 4IEH 1E9 0.003749 0.43973 None
7 2CNT COA 0.004758 0.43779 None
8 4OYA 1VE 0.01988 0.43672 None
9 5AZC PGT 0.03049 0.43416 None
10 5V4R MGT 0.009482 0.42498 None
11 4LWU 20U 0.004299 0.42322 None
12 5IF4 6AK 0.01625 0.42316 None
13 4HIA FMN 0.01709 0.41993 None
14 1TV5 N8E 0.007871 0.41538 None
15 4UCC ZKW 0.01072 0.41394 None
16 2QHD DAO 0.03805 0.41323 None
17 4IBF 1D5 0.007026 0.41311 None
18 1BGQ RDC 0.01639 0.41238 None
19 5HGZ ACO 0.01498 0.41151 None
20 4KVX ACO 0.01653 0.41082 None
21 1YKI FMN 0.02386 0.40912 None
22 1YKI NFZ 0.02765 0.40912 None
23 4DXJ IPE 0.02645 0.40683 None
24 3R96 AMP 0.03392 0.40652 None
25 3R96 ACO 0.03392 0.40652 None
26 3WCA FPS 0.02451 0.40614 None
27 2E3N 6CM 0.0367 0.40062 None
28 2XXP DSL 0.02236 0.4369 2.29885
29 3KDU NKS 0.003371 0.46847 3.44828
30 3FUR Z12 0.004953 0.45784 3.44828
31 3QKD HI0 0.008159 0.42463 3.44828
32 3SP6 IL2 0.006075 0.42234 3.44828
33 1ATL 0QI 0.01235 0.41259 3.44828
34 5D9G GLU ASN LEU TYR PHE GLN 0.0072 0.41243 3.44828
35 1K7L 544 0.02311 0.40353 3.44828
36 1TIQ COA 0.012 0.40206 3.44828
37 4ELG 52J 0.006484 0.42635 4.5977
38 4ELG 52I 0.01586 0.41443 4.5977
39 2VZZ SCA 0.02404 0.40657 4.5977
40 4YV5 SVR 0.01449 0.46491 5.74713
41 1P0H ACO 0.01376 0.44609 5.74713
42 1P0H COA 0.0134 0.44609 5.74713
43 1BZL FAD 0.02546 0.44494 5.74713
44 3B6C SDN 0.0008154 0.43339 5.74713
45 4NB5 2JT 0.003858 0.43186 5.74713
46 1EWF PC1 0.01383 0.42978 5.74713
47 1BZL GCG 0.04829 0.41989 5.74713
48 1YRE COA 0.00896 0.41225 5.74713
49 2WZV FMN 0.02806 0.40982 5.74713
50 5IBE 69M 0.03284 0.40725 5.74713
51 1NUS NMN 0.0467 0.40614 5.74713
52 1GNI OLA 0.001057 0.54858 6.89655
53 3L9R L9Q 0.001544 0.4722 6.89655
54 3L9R L9R 0.003133 0.45651 6.89655
55 5OCA 9QZ 0.01538 0.42062 6.89655
56 2OBD PCW 0.01404 0.41967 6.89655
57 1T8U UAP SGN IDS SGN 0.02157 0.41873 6.89655
58 1U72 MTX 0.0387 0.415 6.89655
59 1U72 NDP 0.0387 0.415 6.89655
60 1S8G DAO 0.008247 0.40754 6.89655
61 1Y7P RIP 0.005516 0.40225 6.89655
62 3T58 FAD 0.0302 0.40152 6.89655
63 3SCM LGN 0.005607 0.46165 8.04598
64 5L2J 6UL 0.008891 0.45646 8.04598
65 5L2J 70E 0.0175 0.4416 8.04598
66 4ZOM 4Q3 0.03307 0.42912 8.04598
67 3ZJ0 ACO 0.007751 0.42573 8.04598
68 5U98 1KX 0.02861 0.42553 8.04598
69 2X5W K2B 0.008993 0.42402 8.04598
70 2WPX ACO 0.009583 0.41277 8.04598
71 1F0X FAD 0.02831 0.41255 8.04598
72 2O1V ADP 0.005973 0.41168 8.04598
73 3UR0 SVR 0.01864 0.40821 8.04598
74 3RUG DB6 0.04612 0.40564 8.04598
75 4MNS 2AX 0.001268 0.49092 9.1954
76 5BVE 4VG 0.002727 0.48153 9.1954
77 3WYJ H78 0.003168 0.48087 9.1954
78 2I0G I0G 0.01011 0.44483 9.1954
79 2P1C GG3 0.005972 0.43714 9.1954
80 1UBY DMA 0.00873 0.4128 9.1954
81 3LDW ZOL 0.02156 0.41137 9.1954
82 1PI5 SM2 0.03487 0.41046 9.1954
83 5D59 78M 0.04646 0.40465 9.1954
84 1FM9 570 0.00275 0.45548 10.3448
85 4JD3 COA 0.009915 0.43924 10.3448
86 4JD3 PLM 0.01074 0.43924 10.3448
87 4OAR 2S0 0.003866 0.43375 10.3448
88 3QCP FAD 0.00637 0.43148 10.3448
89 1WWZ ACO 0.008213 0.42882 10.3448
90 2GMH UQ5 0.008517 0.42053 10.3448
91 1SR7 MOF 0.01888 0.41432 10.3448
92 1CMC SAM 0.01647 0.41228 10.3448
93 3H0A D30 0.02391 0.40413 10.3448
94 2EIX FAD 0.02744 0.4024 10.3448
95 5KAU RHQ 0.000823 0.46422 11.4943
96 4OAS 2SW 0.00242 0.43504 12.5
97 4ZBR DIF 0.004611 0.44672 12.6437
98 3OKI OKI 0.006881 0.44559 12.6437
99 4ZBR NPS 0.01089 0.4265 12.6437
100 2JEV NHQ 0.03239 0.42508 12.6437
101 4P6X HCY 0.01237 0.42488 12.6437
102 1PZO CBT 0.01755 0.42341 12.6437
103 3DCT 064 0.01111 0.41798 12.6437
104 4U03 TLL 0.03226 0.41555 12.6437
105 1NHZ 486 0.01122 0.41464 12.6437
106 4EIL FOL 0.01366 0.40343 12.6437
107 2VL8 UDP 0.002462 0.43919 13.7931
108 2VBQ BSJ 0.01336 0.42543 13.7931
109 1H9G COA MYR 0.01208 0.41904 13.7931
110 2VL8 CTS 0.01356 0.40725 13.7931
111 4EKQ NPO 0.01186 0.40638 13.7931
112 2EV1 OLA 0.01723 0.40546 13.7931
113 1DB1 VDX 0.03153 0.40402 13.7931
114 3VHZ L2P GLC MAN SGA 0.02557 0.41846 14.9425
115 2E2R 2OH 0.01123 0.42931 16.092
116 1DKF BMS 0.00397 0.43681 17.2414
117 3KMZ EQO 0.006394 0.43286 17.2414
118 2XSU PIE 0.01063 0.42319 17.2414
119 1GHE ACO 0.01161 0.41549 17.2414
120 5AAV GW5 0.0008871 0.50455 18.3908
121 2QE4 JJ3 0.0008186 0.50377 18.3908
122 2Z7I 742 0.001795 0.49637 18.3908
123 5B4B LP5 0.002177 0.4592 18.3908
124 2BJ4 OHT 0.002698 0.44133 18.3908
125 3DST GRG 0.03144 0.43139 18.3908
126 4AVB ACO 0.01423 0.41263 18.3908
127 4TMK T5A 0.02304 0.41104 19.5402
128 3HRD FAD 0.03496 0.4104 20.6897
129 3HUJ AGH 0.03356 0.41463 21.8391
130 1BUC CAA 0.02012 0.40514 22.9885
131 3T6E UQ9 0.005399 0.44789 24.1379
132 2D5Z L35 0.01917 0.44445 26.4368
133 5IR4 ZPE 0.02167 0.42139 27.5862
134 4V24 GYR 0.02798 0.40557 29.8851
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