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Receptor
PDB id Resolution Class Description Source Keywords
4IXH 2.11 Å EC: 1.1.1.205 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE INOSINE MON DEHYDROGENASE FROM CRYPTOSPORIDIUM PARVUM CRYPTOSPORIDIUM PARVUM STRUCTURAL GENOMICS NIAID NATIONAL INSTITUTE OF ALLERGY ANINFECTIOUS DISEASES CENTER FOR STRUCTURAL GENOMICS OF INFEDISEASES CSGID ALPHA-BETA FOLD TIM BARREL OXIDOREDUCTAS
Ref.: OPTIMIZATION OF BENZOXAZOLE-BASED INHIBITORS OF CRYPTOSPORIDIUM PARVUM INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE. J.MED.CHEM. V. 56 4028 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
IMP D:501;
A:501;
B:502;
C:501;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
348.206 C10 H13 N4 O8 P c1nc2...
Q21 A:504;
C:502;
B:501;
B:503;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
ic50 = 6.1 nM
409.437 C25 H19 N3 O3 C[C@@...
EDO C:503;
C:504;
A:503;
A:505;
A:502;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4IXH 2.11 Å EC: 1.1.1.205 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE INOSINE MON DEHYDROGENASE FROM CRYPTOSPORIDIUM PARVUM CRYPTOSPORIDIUM PARVUM STRUCTURAL GENOMICS NIAID NATIONAL INSTITUTE OF ALLERGY ANINFECTIOUS DISEASES CENTER FOR STRUCTURAL GENOMICS OF INFEDISEASES CSGID ALPHA-BETA FOLD TIM BARREL OXIDOREDUCTAS
Ref.: OPTIMIZATION OF BENZOXAZOLE-BASED INHIBITORS OF CRYPTOSPORIDIUM PARVUM INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE. J.MED.CHEM. V. 56 4028 2013
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 4IXH ic50 = 6.1 nM Q21 C25 H19 N3 O3 C[C@@H](C(....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 4IXH ic50 = 6.1 nM Q21 C25 H19 N3 O3 C[C@@H](C(....
50% Homology Family (13)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1LRT Ki = 2.3 uM TAD C20 H27 N7 O13 P2 S c1c(nc(s1)....
2 1MEI - MOA C17 H20 O6 Cc1c2c(c(c....
3 1ME9 - IMP C10 H13 N4 O8 P c1nc2c(n1[....
4 1ME8 Ki = 65 nM RVP C8 H13 N4 O8 P c1nc(nn1[C....
5 2BZN - IMP C10 H13 N4 O8 P c1nc2c(n1[....
6 4ZQN Ki = 17 nM 4QO C22 H26 Cl N3 O2 CC(=C)c1cc....
7 4ZQO Ki = 14 nM Q67 C21 H16 Cl2 N4 O2 C[C@@H](C(....
8 4IXH ic50 = 6.1 nM Q21 C25 H19 N3 O3 C[C@@H](C(....
9 5OU3 ic50 = 0.52 uM AUN C22 H20 Br N5 O2 C[C@@H](C(....
10 5OU1 ic50 = 0.77 uM AUQ C16 H16 I N O3 C[C@@H](C(....
11 5K4Z Kd = 0.7 uM 6Q8 C20 H18 F N5 O3 S Cc1c(c([nH....
12 5OU2 ic50 = 674 uM 36Y C9 H7 Br N2 c1cc(ccc1c....
13 5J5R Ki = 0.1 uM 6G1 C20 H25 N3 O3 S c1cc2cnccc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: IMP; Similar ligands found: 76
No: Ligand ECFP6 Tc MDL keys Tc
1 IMP 1 1
2 IDP 0.824324 0.986111
3 R7I 0.759494 0.958904
4 R5I 0.759494 0.958904
5 NOS 0.724638 0.835616
6 5GP 0.609756 0.972603
7 G 0.609756 0.972603
8 DI 0.578313 0.92
9 SIB 0.549451 0.772152
10 93A 0.523256 0.841463
11 GDP 0.505495 0.959459
12 GP3 0.494505 0.934211
13 C2R 0.493827 0.891892
14 GTP 0.489362 0.959459
15 GP2 0.48913 0.922078
16 GNH 0.483871 0.946667
17 G2P 0.479167 0.922078
18 AMZ 0.47561 0.90411
19 SNI 0.475 0.8
20 GMV 0.473684 0.934211
21 GAV 0.469388 0.922078
22 GCP 0.46875 0.934211
23 G1R 0.46875 0.946667
24 AIR 0.468354 0.888889
25 PRT 0.466019 0.972222
26 NIA 0.464286 0.835443
27 9GM 0.463918 0.934211
28 GNP 0.463918 0.934211
29 GSP 0.463918 0.910256
30 AMP 0.458824 0.90411
31 1RB 0.458824 0.847222
32 A 0.458824 0.90411
33 ALF 5GP 0.458333 0.875
34 6SW 0.456522 0.930556
35 RBZ 0.453488 0.837838
36 GPG 0.45098 0.922078
37 7RP 0.448276 0.888889
38 GKE 0.447619 0.922078
39 GDC 0.447619 0.922078
40 GDD 0.447619 0.922078
41 RMB 0.443182 0.835616
42 AAM 0.443182 0.90411
43 P2P 0.443182 0.864865
44 IMO 0.443182 0.890411
45 7RA 0.443182 0.891892
46 FAI 0.443182 0.90411
47 JLN 0.443182 0.90411
48 G2R 0.441176 0.922078
49 G7M 0.43956 0.934211
50 XMP 0.438202 0.932432
51 IRN 0.435897 0.830986
52 Y9Z 0.433962 0.865854
53 71V 0.433333 0.825
54 PMO 0.433333 0.813333
55 GDP AF3 0.431373 0.875
56 ALF GDP 0.431373 0.875
57 GDP ALF 0.431373 0.875
58 JB2 0.431193 0.922078
59 GKD 0.431193 0.922078
60 GFB 0.429907 0.922078
61 GDR 0.429907 0.922078
62 6CK 0.425926 0.898734
63 G3A 0.425926 0.934211
64 YGP 0.424528 0.8875
65 G5P 0.422018 0.934211
66 PGS 0.419355 0.825
67 GTG 0.416667 0.898734
68 RVP 0.416667 0.837838
69 GDX 0.414414 0.934211
70 GUO 0.41 0.931507
71 GMP 0.406977 0.84
72 U2G 0.405172 0.898734
73 2SA 0.40404 0.894737
74 G G 0.40367 0.934211
75 6C6 0.402062 0.846154
76 GPD 0.401786 0.8875
Ligand no: 2; Ligand: Q21; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 Q21 1 1
2 Q67 0.495327 0.705882
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4IXH; Ligand: IMP; Similar sites found with APoc: 259
This union binding pocket(no: 1) in the query (biounit: 4ixh.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 5C2N NAG None
2 5HJQ I3P 1.10803
3 3FPZ AHZ 1.22699
4 2VD9 EPC 1.38504
5 2VD9 IN5 1.38504
6 2GK6 ADP 1.66205
7 4HA6 FAD 1.66205
8 1H82 GZZ 1.66205
9 1H82 FAD 1.66205
10 2XT3 ADP 1.74419
11 5HCN GCP 1.91571
12 2VVG ADP 2
13 4RDH AMP 2.08333
14 4RDI ATP 2.08333
15 5XFV FMN 2.09581
16 3QPB URA 2.12766
17 4CW5 FMN 2.20264
18 4MIG G3F 2.21607
19 4DSG FAD 2.21607
20 5NXX 3Q7 2.23881
21 1DQX BMP 2.24719
22 3A8T ATP 2.35988
23 3U6B GDP 2.49307
24 5YT0 GDP 2.49307
25 3U6K GDP 2.49307
26 5JBQ GDP 2.49307
27 4L8F MTX 2.5641
28 4HKP 16B 2.5641
29 4HKP TKW 2.5641
30 3BJE R1P 2.5788
31 1UJP CIT 2.58303
32 3UWV 2PG 2.68199
33 2Q3O FMN 2.77008
34 5EYW PGA 2.81124
35 3BF1 PAU 2.81124
36 2OFD NGA 2.8169
37 2OFE NAG 2.8169
38 3B0P FMN 2.85714
39 3MI2 PFU 2.86738
40 5ZZO FLC 2.98507
41 2HS3 FGR 3.04709
42 4RKX 3S9 3.06513
43 2QCD U5P 3.07692
44 1M2Z BOG 3.11284
45 1QDS PGA 3.18725
46 4MJ0 SIA SIA 3.27273
47 2WPB ZZI 3.28947
48 5OKU 0L1 3.29341
49 6AMI TRP 3.3241
50 2HIM ASN 3.35196
51 5XH2 NPO 3.43511
52 1Z0A GDP 3.44828
53 3PQC GDP 3.58974
54 4YMZ 13P 3.60111
55 1FDJ 13P 3.60111
56 5L2R MLA 3.60111
57 4XFR CIT 3.60111
58 2BSA NAP 3.63036
59 2BSA FAD 3.63036
60 4AG9 COA 3.63636
61 2WMO GTP 3.68421
62 3TAO PGH 3.74532
63 1DBT U5P 3.76569
64 3DC4 ADP 3.77907
65 1M7G AV2 3.79147
66 1TL2 NDG 3.81356
67 2VL1 GLY GLY 3.87812
68 1W8S FBP 3.87812
69 1GTE IUR 3.87812
70 1GTE FMN 3.87812
71 4FRZ ADP 3.87812
72 4DFU QUE 3.87812
73 4B98 PXG 3.87812
74 3ITA AIC 3.97727
75 4L80 OXL 4.02299
76 3CV6 HXS 4.02477
77 3CV6 NAP 4.02477
78 4WZH FMN 4.03458
79 1CX9 NHP 4.15512
80 1OFD FMN 4.15512
81 3KDN CAP 4.15512
82 1OFD AKG 4.15512
83 4UBS DIF 4.15512
84 1Q6O LG6 4.16667
85 4L9I 8PR 4.16667
86 3KVY URA 4.20712
87 3KVY R2B 4.20712
88 2CBZ ATP 4.21941
89 4Z2S NDG 4.22535
90 4Z2S NAG 4.22535
91 3N9R TD3 4.23453
92 3AI8 HNQ 4.29688
93 2Q3R FMN 4.43213
94 3CQ5 PMP 4.43213
95 4WZ6 ATP 4.48276
96 1T3D CYS 4.49827
97 1JI0 ATP 4.58333
98 2FJK 13P 4.59016
99 1OIJ AKG 4.65116
100 3KRU FMN 4.66472
101 2F6U CIT 4.70085
102 4IGH ORO 4.70914
103 4IGH 1EA 4.70914
104 4IGH FMN 4.70914
105 5YV5 ADP 4.70914
106 1UUO BRF 4.70914
107 1UUO ORO 4.70914
108 1UUO FMN 4.70914
109 5FG3 GDP 4.70914
110 1KBJ FMN 4.70914
111 1KBI FMN 4.70914
112 1KBI PYR 4.70914
113 2AWN ADP 4.72441
114 1GOJ ADP 4.78873
115 2D2F ADP 4.8
116 3OVR 5SP 4.82456
117 6BVE PGA 4.89796
118 4U00 ADP 4.91803
119 6EK3 OUL 4.97738
120 2HSA FMN 4.98615
121 3CV2 OXL 4.98615
122 5OCS FMN 4.98615
123 2OG2 MLI 5.01393
124 1Z44 FMN 5.02959
125 1Z48 FMN 5.02959
126 1Z41 FMN 5.02959
127 1Z42 FMN 5.02959
128 2BE5 TGT 5.05051
129 3BFX A3P 5.06757
130 3LRE ADP 5.07042
131 6BKA FMN 5.26316
132 4DCT GDP 5.26316
133 4M3P HCS 5.26316
134 3K56 IS3 5.26316
135 1TE2 PGA 5.30973
136 4L9Z OXL 5.30973
137 1OVD ORO 5.46624
138 1OVD FMN 5.46624
139 5GJO PLP 5.54017
140 2V67 CAP 5.54017
141 1UZD CAP 5.54017
142 2V68 CAP 5.54017
143 1IR2 CAP 5.54017
144 1UZH CAP 5.54017
145 2RJH DCS 5.54017
146 2V63 CAP 5.54017
147 2VDH CAP 5.54017
148 2V6A CAP 5.54017
149 4I9A NCN 5.55556
150 5FQK 6NT 5.57621
151 1SW0 PGA 5.64516
152 4O48 ASP 5.72289
153 3OIX FMN 5.7971
154 1T5C ADP 5.81717
155 1G6H ADP 5.83658
156 5XQL C2E 5.84192
157 3RK0 AMP 5.90717
158 1RYH GNP 5.91133
159 3B9Q MLI 5.96026
160 5NM7 GLY 6.01504
161 2OO0 PLP 6.09418
162 2AJH MET 6.12245
163 6FTB M0E 6.19048
164 3W9Z FMN 6.21118
165 4K79 GAL A2G 6.36364
166 5TCI MLI 6.37119
167 4R8L ASP 6.37119
168 1P7T PYR 6.6482
169 1D8C GLV 6.6482
170 4U8P FDA 6.6482
171 1LYX PGA 6.85484
172 2WG9 OCA 6.92308
173 2J5V PCA 6.92521
174 3GLC R5P 7.11864
175 3MJY IJZ 7.22543
176 3MJY FMN 7.22543
177 4D52 GXL 7.30159
178 2JK0 ASP 7.38462
179 3WY9 GDP 7.47922
180 2WHX ADP 7.47922
181 1ICP FMN 7.47922
182 3HQP OXL 7.47922
183 4IF4 BEF 7.69231
184 4QNW FMN 7.75623
185 3BC9 ACR 7.75623
186 4YDS ATP 7.89474
187 2CFC KPC 8
188 4CCW VKC 8.02676
189 1OX5 1PR 8.03324
190 2VVL FAD 8.03324
191 2Y88 2ER 8.19672
192 4UTU LRY 8.29694
193 4UTW RFW 8.29694
194 5N9Z CAP 8.31025
195 2P39 SCR 8.3871
196 1GVF PGH 8.39161
197 2YPI PGA 8.50202
198 1G7C 5GP 8.51064
199 4LPS GDP 8.67769
200 5A5W GUO 8.69565
201 1TRD PGH 8.8
202 4ORM FMN 8.86427
203 4ORM 2V6 8.86427
204 4ORM ORO 8.86427
205 1TV5 FMN 8.86427
206 4NAE 1GP 8.88889
207 3H4S ADP 8.88889
208 1M5W DXP 9.0535
209 2OFW ADX 9.13461
210 3C3N FMN 9.29487
211 1EP2 ORO 9.32476
212 5Z3I ADE 9.69529
213 3G2O SAM 9.699
214 1TB3 FMN 9.94318
215 2IZ1 ATR 10.2493
216 2NGR GDP 10.2564
217 3KIH GDL 10.3093
218 3QH2 3NM 10.4072
219 2XTZ GSP 10.452
220 1JG3 ADN 10.6383
221 4JEJ 1GP 10.6557
222 5ZI9 FLC 10.7692
223 2Z6I FMN 10.8434
224 3OTH TYD 11.0803
225 2BTM PGA 11.5079
226 3N5C GDP 11.7284
227 2NV2 GLN 11.7647
228 6HKE LMR 11.9497
229 1G16 GDP 12.3529
230 1LBF 137 12.5506
231 3HY2 ATP 12.7273
232 5O74 GDP 12.7778
233 1RBL CAP 12.844
234 1Z0F GDP 12.8492
235 3BW2 FMN 13.5734
236 2BD0 BIO 13.9344
237 3AXK NDP 13.9535
238 1WDD CAP 14.0625
239 4BI7 PGA 15.1751
240 4Q4K FMN 15.4062
241 3EXS 5RP 15.8371
242 2FWP ICR 15.847
243 3CTL S6P 16.0173
244 4EWN 0VR 16.2055
245 1JCM 137 16.6023
246 4YMU ATP 16.8182
247 5CGE 51F 16.9675
248 1VBO MAN 17.4497
249 2HCJ GDP 18.9189
250 2ZRU FMN 20.2216
251 2FLI DX5 20.4545
252 5CSS G3P 20.7965
253 1VKF CIT 21.2766
254 1US5 GLU 24.5223
255 2GJN NIS 25.3049
256 2GJN FMN 25.3049
257 2Z6J FMN 28.6145
258 2FKA BEF 33.3333
259 5GVH FMN 37.8981
Pocket No.: 2; Query (leader) PDB : 4IXH; Ligand: Q21; Similar sites found with APoc: 10
This union binding pocket(no: 2) in the query (biounit: 4ixh.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 2E4U GLU 1.93906
2 2UVO NAG 2.92398
3 2UVO NDG 2.92398
4 2HIM ASN 3.35196
5 2ZB3 NDP 5.94901
6 3KCC CMP 7.30769
7 2VVL FAD 8.03324
8 3O5N BR0 8.92857
9 4LNU GTP 12.426
10 5EIB GTP 12.426
Pocket No.: 3; Query (leader) PDB : 4IXH; Ligand: IMP; Similar sites found with APoc: 70
This union binding pocket(no: 3) in the query (biounit: 4ixh.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 1D2E GDP 1.66205
2 5KUT GDP 2.1164
3 6F97 FAD 2.21607
4 5K4G ASP 2.42424
5 2WPF FAD 2.49307
6 2WPF WPF 2.49307
7 2BVN GNP 2.49307
8 1D8T GDP 2.49307
9 4JP3 CIT 2.51046
10 1BH2 GSP 2.53968
11 1F9V ADP 2.59366
12 2X65 M1P 2.67857
13 1VG1 GDP 2.7027
14 5MBX SP5 2.77008
15 5MBX FAD 2.77008
16 5ZXD ATP 2.77008
17 2B9W FAD 2.77008
18 1GPE FAD 3.04709
19 2CUN 3PG 3.04709
20 4E70 N7I 3.04709
21 5E58 CPZ 3.04709
22 3MD0 GDP 3.04709
23 2A5J GDP 3.14136
24 6CUZ FEV 3.3241
25 2HIM ASP 3.35196
26 2J8R MSL 3.48837
27 1FDJ 2FP 3.60111
28 4QYS PLR 3.61991
29 4QYS PLP SEP 3.61991
30 1A4R GNH 3.66492
31 1O5Q PYR 3.93443
32 5K21 6QF 4.25532
33 6ACS CIT 4.26357
34 3HDY FAD 4.43213
35 3HDY GDU 4.43213
36 1I4D GDP 4.46429
37 2VWT PYR 4.49438
38 1YRB GDP 4.58015
39 1FHX 4IP 4.65116
40 1YQT ADP 4.70914
41 1F76 FMN 4.7619
42 2V7Q ADP 4.79452
43 1OYF MHN 4.95868
44 1RYD GLC 5.26316
45 3B5J 12D 5.34979
46 5WLB GNP 5.42169
47 2B6N ALA PRO THR 5.7554
48 2GMM MAN MAN 5.95238
49 1PEA ACM 6.09418
50 3QXQ CE5 6.19718
51 4U8P UDP 6.6482
52 1DCP HBI 6.73077
53 4FCW ADP 7.3955
54 2VVM FAD 8.03324
55 1D1Q 4NP 8.07453
56 3IWD M2T 8.82353
57 2WET TRP 8.86427
58 1EP2 FMN 9.32476
59 4D0N GDP 9.41828
60 4PPF FLC 9.42857
61 6C74 PC 10.8108
62 4WBD CIT 11.3573
63 6HKE MLT 11.9497
64 3BOS CDP 12.3967
65 3CYI ATP 12.7273
66 3G89 SAM 13.253
67 3ETG NDP 13.2964
68 3ETG GLU 13.2964
69 1X1Z BMP 19.4444
70 1AL8 DHP 20.3343
Pocket No.: 4; Query (leader) PDB : 4IXH; Ligand: Q21; Similar sites found with APoc: 4
This union binding pocket(no: 4) in the query (biounit: 4ixh.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 3KLL MAL 4.98615
2 2E2P ADP 6.68896
3 3RYC GTP 8.03324
4 2VVM FAD 8.03324
Pocket No.: 5; Query (leader) PDB : 4IXH; Ligand: Q21; Similar sites found with APoc: 6
This union binding pocket(no: 5) in the query (biounit: 4ixh.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 1OS7 TAU 3.18021
2 4B7X NAP 4.16667
3 5H4S RAM 7.74648
4 1JQ5 NAD 9.41828
5 4MZU TDR 14.4231
6 2VHW NAI 15.2355
Pocket No.: 6; Query (leader) PDB : 4IXH; Ligand: IMP; Similar sites found with APoc: 42
This union binding pocket(no: 6) in the query (biounit: 4ixh.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 5W76 GDP 1.66205
2 6BSW UDP 1.77515
3 2IS6 ADP 2.21607
4 1SVK ALF GDP 2.26629
5 3GGF GVD 2.32558
6 1V6A TRE 2.40964
7 4P3Y GDP 2.49307
8 5A0U CHT 2.77008
9 3E4O SIN 2.95082
10 2JFQ DGL 3.14685
11 4D79 ATP 3.26087
12 6AM8 PLT 3.3241
13 4BWL MN9 3.61842
14 4BGB ADP 3.69231
15 2F57 23D 3.78549
16 2GJP MAL 3.87812
17 4USI AKG 3.8961
18 2HT6 GDP 4.02299
19 6A20 ADP 4.43213
20 3AB3 GDP 4.43213
21 5UJ3 CE4 4.82759
22 1G7S GDP 5.54017
23 5YSQ INS 5.59441
24 5VKI THR NGA GAL NAG 5.625
25 5JNW 6LJ 5.66038
26 2G50 ALA 6.09418
27 1FQK GDP 6.12245
28 1C1X HFA 7.32394
29 3IB1 IMN 7.53623
30 4YJK URA 7.53968
31 3I7S PYR 7.87671
32 5TE1 7A2 8.03324
33 1RE0 GDP 8.1448
34 1Y7P RIP 8.52018
35 4DKX GDP 9.25926
36 4PVR ASP 10.6452
37 1G51 AMP 11.3573
38 2JBH 5GP 12.8889
39 4D0G GTP 13.1429
40 1WHT BZS 13.7255
41 2ZFZ ARG 20.2532
42 1XXA ARG 26.9231
Pocket No.: 7; Query (leader) PDB : 4IXH; Ligand: Q21; Similar sites found with APoc: 3
This union binding pocket(no: 7) in the query (biounit: 4ixh.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 5EOB 5QQ 2.50784
2 2DM6 NAP 4.5045
3 1G8K MGD 6.76692
Pocket No.: 8; Query (leader) PDB : 4IXH; Ligand: IMP; Similar sites found with APoc: 34
This union binding pocket(no: 8) in the query (biounit: 4ixh.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 5C9P FUC 1.38504
2 3ITJ CIT 2.07101
3 4DDY DN6 2.28137
4 1JJ7 ADP 2.30769
5 4MOB ADP 2.40964
6 4G5G GDP 2.49307
7 3RHC GSH 2.65487
8 2NUN ADP 2.78638
9 5N6N SUC 2.91667
10 5W7Q GDP 3.04709
11 1SVI GDP 3.07692
12 2ZX2 RAM 3.58974
13 4B47 GDP 3.85675
14 3HDY FDA 4.43213
15 1R6B ADP 4.70914
16 1RHC F42 ACN 4.84848
17 2PYU IMP 5.47945
18 2OEM 1AE 5.54017
19 1NXJ TLA 6.01093
20 3WCS MAN NAG GAL 6.29921
21 5A1S FLC 7.20222
22 1GRN AF3 7.38916
23 1P4V GLY 7.45763
24 3MYU VIB 8.13953
25 5DNC ASN 8.86427
26 1JXN MFU 9.09091
27 1FQJ GDP 9.52381
28 1KUJ MMA 10.5263
29 5LX9 OLB 10.5634
30 3HRD NIO 13.5734
31 4MZU TDR 14.4231
32 1I7Q PYR 15.544
33 6FLZ MMA 16.6667
34 4PTN GXV 17.2012
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