-->
Receptor
PDB id Resolution Class Description Source Keywords
4J25 1.97 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A PSEUDOMONAS PUTIDA PROLYL-4-HYDROXYLA PSEUDOMONAS PUTIDA 2-OXOGLUTARATE OXYGENASE OXYGEN SENSING DOUBLE-STRANDED BEJELLYROLL FOLD PROLYL-4-HYDROXYLASE OXIDOREDUCTASE
Ref.: HUMAN OXYGEN SENSING MAY HAVE ORIGINS IN PROKARYOTI ELONGATION FACTOR TU PROLYL-HYDROXYLATION PROC.NATL.ACAD.SCI.USA V. 111 13331 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
OGA H:402;
G:402;
C:402;
A:402;
F:402;
D:402;
E:402;
B:402;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
147.086 C4 H5 N O5 C(C(=...
MN D:401;
H:401;
B:401;
C:401;
A:401;
E:401;
F:401;
G:401;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4J25 1.97 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A PSEUDOMONAS PUTIDA PROLYL-4-HYDROXYLA PSEUDOMONAS PUTIDA 2-OXOGLUTARATE OXYGENASE OXYGEN SENSING DOUBLE-STRANDED BEJELLYROLL FOLD PROLYL-4-HYDROXYLASE OXIDOREDUCTASE
Ref.: HUMAN OXYGEN SENSING MAY HAVE ORIGINS IN PROKARYOTI ELONGATION FACTOR TU PROLYL-HYDROXYLATION PROC.NATL.ACAD.SCI.USA V. 111 13331 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 4J25 - OGA C4 H5 N O5 C(C(=O)O)N....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 4J25 - OGA C4 H5 N O5 C(C(=O)O)N....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 4J25 - OGA C4 H5 N O5 C(C(=O)O)N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OGA; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 OGA 1 1
2 AAC 0.461538 0.827586
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found with APoc: 208
This union binding pocket(no: 1) in the query (biounit: 4j25.bio8) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 1VYF OLA None
2 1LFO OLA None
3 5CLO NS8 None
4 3VHH VHH 1.31004
5 2F01 BTQ 1.5748
6 2F01 BTN 1.5748
7 6F4T OGA 1.74672
8 2WA4 069 2.18341
9 1OS7 AKG 2.18341
10 1OS7 TAU 2.18341
11 6F6D AKG 2.18341
12 5FP3 3JI 2.18341
13 5A3T MMK 2.18341
14 2XUM OGA 2.18341
15 3P3N AKG 2.18341
16 5JWP AKG 2.18341
17 4B7E OGA 2.18341
18 2Y0I AKG 2.18341
19 1ZOA 140 2.18341
20 1GT4 UNA 2.18341
21 1QIN GIP 2.18579
22 2NNQ T4B 2.29008
23 4JNJ BTN 2.6087
24 5C3R AKG 2.62009
25 5C3R HMU 2.62009
26 1NX4 AKG 2.62009
27 3PUR 2HG 2.62009
28 3N9P OGA 2.62009
29 3N9O OGA 2.62009
30 3N9Q OGA 2.62009
31 4CSD MFU 2.62009
32 1GQG DCD 2.62009
33 1XPK HMG 2.62009
34 1J3R 6PG 2.63158
35 4UF0 MMK 3.05677
36 6EXF LYS 3.05677
37 3NW7 LGV 3.05677
38 3RUG DB6 3.05677
39 2IHK CSF 3.05677
40 5B4T 3HR 3.05677
41 5B4T NAD 3.05677
42 5Y4K AKR 3.05677
43 3IAL PR8 3.05677
44 2OG7 SIN 3.08123
45 1WBI BTN 3.10078
46 4QAC KK3 3.22581
47 3E2M E2M 3.24324
48 2X34 UQ8 3.31492
49 4A6F SEP 3.33333
50 1KZN CBN 3.41463
51 2QL9 CIT 3.46821
52 4NAO AKG 3.49345
53 5MW4 5JU 3.49345
54 1X8J A3P 3.49345
55 4O9S 2RY 3.49345
56 3EM0 CHD 3.62319
57 2QM9 TDZ 3.87097
58 2A1X AKG 3.8961
59 1OIK C26 3.93013
60 1OIK AKG 3.93013
61 1OIJ AKG 3.93013
62 5F3I 5UJ 3.93013
63 5LY2 OGA 3.93013
64 1OFZ FUL 3.93013
65 2OS2 OGA 3.93013
66 6H8P OGA 3.93013
67 5FWE OGA 3.93013
68 2Q8E OGA 3.93013
69 2XIQ MLC 3.93013
70 2YBP 2HG 3.93013
71 2P5B OGA 3.93013
72 1WLE SRP 3.93013
73 1SES AHX 3.93013
74 4ZLU 4PW 3.93013
75 4BJ8 BTN 3.96825
76 5O9W AKG 4.36681
77 2WBP SIN 4.36681
78 2WBP ZZU 4.36681
79 5IVE 6E8 4.36681
80 6F6J CUW 4.36681
81 6F6J SIN 4.36681
82 1MH5 HAL 4.36681
83 5E2N V14 4.36681
84 5WBF LAC 4.44444
85 3ZW2 GLA NAG GAL FUC 4.5977
86 3ZW2 NAG GAL FUC 4.5977
87 3ZW2 GAL FUC 4.5977
88 5A65 TPP 4.60829
89 1Y52 BTN 4.7619
90 4XCB HY0 4.80349
91 4XCB AKG 4.80349
92 4CCO OGA 4.80349
93 4Y3O OGA 4.80349
94 4CCK OGA 4.80349
95 3AMN CBI 4.80349
96 3AMN CBK 4.80349
97 4L4J NAG NAG BMA MAN NAG 4.97738
98 2Z77 HE7 5.03597
99 3EW2 BTN 5.18518
100 2HFN FMN 5.22876
101 4OCT AKG 5.24017
102 1GP6 QUE 5.24017
103 1GP6 DH2 5.24017
104 1GP6 SIN 5.24017
105 4P7X YCP 5.24017
106 4P7X AKG 5.24017
107 4BG1 IVL 5.24017
108 4BG1 OGA 5.24017
109 5FP4 YC8 5.24017
110 4D4U FUC GAL NAG 5.24017
111 4D52 GXL 5.24017
112 4D52 GIV 5.24017
113 4D4U FUC NDG GAL FUC 5.24017
114 4D4U FUC GAL NDG FUC 5.24017
115 1N5S ADL 5.35714
116 5GM5 CBI 5.45455
117 4BX7 B4F 5.46875
118 3GM5 CIT 5.66038
119 2ZSC BTN 5.67376
120 4NPL AKG 5.67686
121 4BXF AKG 5.67686
122 4B1M FRU FRU 5.67686
123 4XYM A12 5.67686
124 4B1L FRU 5.67686
125 6HDT BTN 6.01504
126 5MBC FMN 6.11354
127 3A6T 8OG 6.11354
128 4V24 GYR 6.55022
129 3RGA LSB 6.55022
130 5EQU 5R6 6.55022
131 5EQU AKG 6.55022
132 6F7X MFU 6.66667
133 1QY1 PRZ 6.89655
134 2WPU KYT 6.91824
135 4GGZ BTN 6.95652
136 5JSP DQY 6.96517
137 5NCJ SIN 6.9869
138 5NCJ HL5 6.9869
139 3PQB VGP 6.9869
140 5KR7 6X9 6.9869
141 4BCS BTN 7.2
142 1WUB OTP 7.30337
143 4RFR RHN 7.42358
144 2FCU AKG 7.42358
145 4IY7 0JO 7.42358
146 4IYO 0JO 7.42358
147 4IY7 KOU 7.42358
148 6GBV FMN 7.53425
149 5HV0 AKG 7.86026
150 5FWJ MMK 7.86026
151 2C1Q BTN 7.93651
152 1TW4 CHD 8
153 4F7E 0SH 8.16327
154 1DRY AAG 8.29694
155 1DRY AKG 8.29694
156 5ML3 DL3 8.72483
157 1W3T 3GR 8.73362
158 1YQS BSA 8.73362
159 2ET1 GLV 8.95522
160 2IUW AKG 9.17031
161 6EOZ AKG 9.17031
162 6EOZ 58K 9.17031
163 4QXB OGA 9.17031
164 3KV4 OGA 9.17031
165 5ZM4 AKG 9.17031
166 5ZM4 9FU 9.17031
167 6MPT C30 9.17031
168 3ROE THM 9.17031
169 1PZO CBT 9.17031
170 2FDW D3G 9.17031
171 2GJ5 VD3 9.25926
172 4EKV BTN 9.43396
173 3AVR OGA 9.60699
174 6FUL E7Z 9.60699
175 5I0U DCY 9.60699
176 3MJY IJZ 9.60699
177 3MJY FMN 9.60699
178 6FXR AKG 10.0437
179 4LIT AKG 10.0437
180 4Z28 BTN 10.4478
181 4M26 ZZU 10.4803
182 4M26 SIN 10.4803
183 4M26 AKG 10.4803
184 2UZ2 BTN 10.7692
185 3OPT AKG 10.917
186 4CCN OGA 11.4286
187 1H2M OGA 11.5385
188 2RDQ AKG 12.6638
189 4OJ8 AKG 12.6638
190 4OJ8 2TQ 12.6638
191 4QM9 CYS 12.6638
192 5U98 1KX 13.1313
193 1UNB PN1 13.5371
194 1UNB AKG 13.5371
195 5D48 L96 13.8158
196 5TFZ 7BC 14
197 4Z3X 4KX 14.5251
198 4Z3X MTE 14.5251
199 1H2K OGA 14.6341
200 1ODM ASV 15.7205
201 5XEG AKG 20.524
202 5YBL AKG 21.8341
203 2JIG PD2 22.2707
204 4IE6 UN9 29.2576
205 3HQR OGA 38.8646
206 4JZR 4JR 38.8646
207 5OX6 A1Z 42.3581
208 5C5T AKG 43.2314
Pocket No.: 2; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found with APoc: 36
This union binding pocket(no: 2) in the query (biounit: 4j25.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 5HZ5 65X None
2 1SWG BTN 1.5625
3 1TQP ATP 1.74672
4 3PFG TLO 2.62009
5 3PFG SAM 2.62009
6 3U2U UDP 2.62009
7 3FW4 CAQ 2.80899
8 2JLD AG1 3.05677
9 1RJW ETF 3.49345
10 2ARC ARA 3.49345
11 5U3B 7TD 3.49345
12 5LXB 7A9 3.49345
13 1OFZ FUC 3.93013
14 4TVD BGC 3.93013
15 3T50 FMN 4.6875
16 2XN5 FUN 4.80349
17 5TDF ADP 4.80349
18 1V7R CIT 4.83871
19 3AI7 TPP 5.67686
20 5XIJ ANP 6.55022
21 5XIJ 873 6.55022
22 3SCM LGN 6.9869
23 5FLJ QUE 6.98925
24 1KBJ FMN 8.29694
25 4QDF 30Q 8.73362
26 5LU5 M7P 8.73362
27 4RW3 IPD 9.17031
28 2GC0 PAN 9.57447
29 3RE4 TO1 10.0437
30 5FR0 SIZ 10.0437
31 1ZTH ADP 10.0437
32 1ZP9 ATP 10.0437
33 3RDO BTN 10.4575
34 4R3U 3KK 10.4803
35 4R3U 3HC 10.4803
36 3SAO NKN 13.75
Pocket No.: 3; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found with APoc: 24
This union binding pocket(no: 3) in the query (biounit: 4j25.bio6) has 14 residues
No: Leader PDB Ligand Sequence Similarity
1 3GGU 017 None
2 1XLI GLT 1.31004
3 2YI0 YI0 1.74672
4 1LN1 DLP 2.33645
5 5FKP 6UL 2.62009
6 3GAY P6T 2.62009
7 3STK PLM 3.0303
8 1QG6 TCL 3.49345
9 1QG6 NAD 3.49345
10 5DEP UD1 3.49345
11 1JS3 PLP 142 4.36681
12 3ZW0 FUC 4.5977
13 1ZDT PEF 4.80349
14 5HES 032 5.24017
15 1AJ0 SAN 6.11354
16 1AJ0 PH2 6.11354
17 1Y0G 8PP 6.80628
18 2E56 MYR 6.94444
19 3QUZ QUV 6.9869
20 6CAY ERG 9.46746
21 3ZGJ RMN 10.0437
22 2ABS ACP 11.3537
23 4X6F 3XU 12.381
24 4WO4 JLS 13
Pocket No.: 4; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found with APoc: 25
This union binding pocket(no: 4) in the query (biounit: 4j25.bio7) has 15 residues
No: Leader PDB Ligand Sequence Similarity
1 3TM0 ANP None
2 3TM0 B31 None
3 4FFG 0U8 2.62009
4 4FFG LBS 2.62009
5 2RHW C0E 2.62009
6 6ADI 9UO 2.62009
7 1MI3 NAD 2.62009
8 4GJ3 0XP 4.36681
9 4BKS X6C 4.80349
10 2CER PGI 5.24017
11 5XQW 8EU 6.55022
12 5GLT BGC GAL NAG GAL 6.55022
13 3SCH TB6 6.56566
14 1ZZ7 S0H 6.56566
15 1VJY 460 6.9869
16 5XFV FMN 6.9869
17 5B4B LP5 7.66129
18 2ZI8 SDT 7.86026
19 2Q8Z NUP 8.29694
20 1OGZ EQU 9.17031
21 6C6O ENG 9.17031
22 2CET PGI 10.917
23 4H6B 10Y 10.917
24 4H6B 10X 10.917
25 1TKK ALA GLU 11.3537
Pocket No.: 5; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found with APoc: 9
This union binding pocket(no: 5) in the query (biounit: 4j25.bio2) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 4WW8 VD9 2.18341
2 4IMG NGF 3.05677
3 4AZP A9M 4.34783
4 1KQW RTL 4.47761
5 1DMY AZM 4.80349
6 2YNE YNE 6.55022
7 2YNE NHW 6.55022
8 5UIU 8CG 8.29694
9 3KV8 FAH 13.5371
Pocket No.: 6; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found with APoc: 8
This union binding pocket(no: 6) in the query (biounit: 4j25.bio4) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 5BVT PAM None
2 1X0P FAD 1.3986
3 1RQ5 CTT 3.05677
4 3E9I XAH 3.49345
5 2VVM PRO 3.49345
6 1UU1 PMP HSA 4.36681
7 4D4U FUC GAL 5.24017
8 3DG6 MUC 13.1004
Pocket No.: 7; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found with APoc: 16
This union binding pocket(no: 7) in the query (biounit: 4j25.bio3) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 5Y72 DST 1.74672
2 6H36 FKE 2.62009
3 1ERB ETR 2.73224
4 2QCS ANP 3.05677
5 4B4D FAD 3.05677
6 3COW 52H 3.49345
7 3N0Y APC 3.91061
8 1CX9 NHP 5.24017
9 4F9C 0SX 5.55556
10 2XK9 XK9 5.67686
11 5I0F GLC GLC 6.55022
12 2TPS TPS 6.60793
13 2BS5 BGC GAL FUC 6.66667
14 2WLG SOP 8.37209
15 4WVO 3UZ 9.17031
16 3DBX PLM 13.1313
Pocket No.: 8; Query (leader) PDB : 4J25; Ligand: OGA; Similar sites found with APoc: 16
This union binding pocket(no: 8) in the query (biounit: 4j25.bio5) has 15 residues
No: Leader PDB Ligand Sequence Similarity
1 5OO5 UUA None
2 3WUC GLC GAL 1.45985
3 5UR6 8KM 2.62009
4 1T27 PCW 3.49345
5 4B7P 9UN 3.93013
6 5KD6 6C7 3.93013
7 5KD6 LBU 3.93013
8 5UC4 83S 4.09091
9 4D4U FUC 5.24017
10 3WDX BGC BGC GLC 5.67686
11 1LRH NLA 6.13497
12 3RMK BML 6.9869
13 4QYN RTL 8.27068
14 4G7A AZM 9.60699
15 3MPB FRU 9.60699
16 4DS8 A8S 20.9607
APoc FAQ
Feedback