Receptor
PDB id Resolution Class Description Source Keywords
4LC1 1.8 Å EC: 3.-.-.- MEAB, A BACTERIAL HOMOLOG OF MMAA, BOUND TO GDP AND CRYSTALL THE PRESENCE OF GDP AND [ALF4]- METHYLOBACTERIUM EXTORQUENS ALPHA AND BETA PROTEIN METALLOCHAPERONE CHAPERONE
Ref.: AUTOINHIBITION AND SIGNALING BY THE SWITCH II MOTIF G-PROTEIN CHAPERONE OF A RADICAL B12 ENZYME. J.BIOL.CHEM. V. 288 30980 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GDP B:401;
A:401;
Valid;
Valid;
none;
none;
submit data
443.201 C10 H15 N5 O11 P2 c1nc2...
GOL A:402;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4LC1 1.8 Å EC: 3.-.-.- MEAB, A BACTERIAL HOMOLOG OF MMAA, BOUND TO GDP AND CRYSTALL THE PRESENCE OF GDP AND [ALF4]- METHYLOBACTERIUM EXTORQUENS ALPHA AND BETA PROTEIN METALLOCHAPERONE CHAPERONE
Ref.: AUTOINHIBITION AND SIGNALING BY THE SWITCH II MOTIF G-PROTEIN CHAPERONE OF A RADICAL B12 ENZYME. J.BIOL.CHEM. V. 288 30980 2013
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 218 families.
1 4JYB - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
2 2QM7 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 4JYC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
4 4LC1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 176 families.
1 4JYB - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
2 2QM7 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 4JYC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
4 4LC1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 143 families.
1 3MD0 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 4JYB - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
3 2QM7 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
4 4JYC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
5 4LC1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
6 3TK1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GDP; Similar ligands found: 153
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 1 1
2 GTP 0.909091 1
3 GP3 0.881579 0.973684
4 GNH 0.858974 0.986667
5 GNP 0.839506 0.973684
6 G 0.828947 0.986486
7 5GP 0.828947 0.986486
8 G1R 0.82716 0.986667
9 GCP 0.82716 0.973684
10 GSP 0.817073 0.948718
11 GAV 0.797619 0.961039
12 GMV 0.792683 0.973684
13 G2P 0.77381 0.961039
14 G2R 0.770115 0.961039
15 GDP MG 0.759036 0.923077
16 GP2 0.756098 0.961039
17 GDP BEF 0.75 0.9
18 GDD 0.747253 0.961039
19 GKE 0.747253 0.961039
20 GDC 0.747253 0.961039
21 GPG 0.741573 0.961039
22 G3D 0.732558 0.986486
23 ALF 5GP 0.729412 0.888889
24 Y9Z 0.728261 0.902439
25 GTP MG 0.724138 0.923077
26 BEF GDP 0.724138 0.888889
27 G5P 0.723404 0.973684
28 GFB 0.72043 0.961039
29 GTG 0.72043 0.936709
30 GDR 0.72043 0.961039
31 G4P 0.715909 0.986486
32 GCP G 0.715909 0.935065
33 6CK 0.712766 0.936709
34 G3A 0.712766 0.973684
35 GDP ALF 0.7 0.888889
36 GDP AF3 0.7 0.888889
37 YGP 0.698925 0.901235
38 JB2 0.697917 0.961039
39 GKD 0.697917 0.961039
40 GDX 0.690722 0.973684
41 GPD 0.690722 0.925
42 GMP 0.684211 0.88
43 0O2 0.666667 0.986486
44 G G 0.659574 0.935065
45 JB3 0.656863 0.948718
46 NGD 0.650485 0.961039
47 GDP 7MG 0.636364 0.911392
48 DGI 0.636364 0.923077
49 U2G 0.634615 0.936709
50 GPX 0.634409 0.946667
51 IDP 0.632184 0.972973
52 2MD 0.632075 0.891566
53 CAG 0.62963 0.880952
54 CG2 0.622642 0.936709
55 FEG 0.619048 0.879518
56 MGD 0.614679 0.891566
57 ZGP 0.613208 0.869048
58 GH3 0.612903 0.973333
59 3GP 0.611765 0.946667
60 MD1 0.607143 0.891566
61 PGD 0.59292 0.925
62 DGT 0.591398 0.923077
63 BGO 0.588785 0.924051
64 TPG 0.582609 0.840909
65 DBG 0.582609 0.948718
66 2GP 0.574713 0.96
67 FE9 0.570175 0.776596
68 I2C FE2 CMO CMO 0.566372 0.808989
69 G A A A 0.553571 0.923077
70 MGP 0.553191 0.961039
71 U A G G 0.548673 0.935065
72 G4M 0.548387 0.880952
73 6G0 0.547368 0.961039
74 G1R G1R 0.542373 0.924051
75 P2G 0.527473 0.883117
76 PGD O 0.525 0.850575
77 ADP 0.522222 0.92
78 GGM 0.517544 0.901235
79 DG 0.516484 0.910256
80 DGP 0.516484 0.910256
81 P1G 0.516129 0.871795
82 G G U 0.509259 0.935065
83 G1G 0.508475 0.925
84 IMP 0.505495 0.959459
85 G C 0.504348 0.9
86 GPC 0.491525 0.879518
87 G7M 0.483871 0.948052
88 6AD 0.479592 0.841463
89 ATP 0.473684 0.92
90 G2Q 0.471154 0.961039
91 U G A 0.469697 0.888889
92 5FA 0.46875 0.92
93 AQP 0.46875 0.92
94 GTA 0.468468 0.936709
95 7DD 0.468085 0.906667
96 G G G RPC 0.466102 0.875
97 SGP 0.463158 0.82716
98 01G 0.462963 0.902439
99 B4P 0.457447 0.894737
100 AP5 0.457447 0.894737
101 A2D 0.456522 0.894737
102 G G G C 0.455285 0.9125
103 ACQ 0.454545 0.896104
104 5GP 5GP 0.454545 0.883117
105 ANP 0.454545 0.896104
106 A G C C 0.451613 0.911392
107 APC G U 0.45082 0.886076
108 G U34 0.449153 0.888889
109 DG DG 0.448598 0.865854
110 ITT 0.447917 0.868421
111 BA3 0.446809 0.894737
112 35G 0.444444 0.933333
113 C2E 0.444444 0.921053
114 PCG 0.444444 0.933333
115 MGO 0.441176 0.864198
116 AN2 0.4375 0.907895
117 G C C C 0.4375 0.924051
118 M33 0.43299 0.883117
119 UCG 0.429688 0.911392
120 A G U 0.42963 0.888889
121 ACP 0.428571 0.896104
122 MGQ 0.424528 0.935897
123 7DT 0.424242 0.906667
124 APR 0.424242 0.894737
125 AR6 0.424242 0.894737
126 93A 0.42268 0.833333
127 A4P 0.420168 0.869048
128 SAP 0.42 0.873418
129 AD9 0.42 0.896104
130 AGS 0.42 0.873418
131 G8D 0.42 0.875
132 CA0 0.418367 0.896104
133 ATF 0.417476 0.884615
134 AGO 0.414634 0.888889
135 NIA 0.413043 0.82716
136 MGV 0.412844 0.890244
137 TAT 0.411765 0.884615
138 A1R 0.411215 0.839506
139 ADQ 0.411215 0.871795
140 RGT 0.410714 0.909091
141 CGP 0.409836 0.86747
142 AMP 0.408602 0.893333
143 A 0.408602 0.893333
144 UP5 0.40678 0.873418
145 C2R 0.406593 0.906667
146 AMZ 0.406593 0.918919
147 JBT 0.405882 0.778947
148 A22 0.40566 0.907895
149 25L 0.405405 0.907895
150 ADX 0.40404 0.809524
151 8OD 0.401961 0.946667
152 4TC 0.4 0.851852
153 50T 0.4 0.883117
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4LC1; Ligand: GDP; Similar sites found: 576
This union binding pocket(no: 1) in the query (biounit: 4lc1.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2FNA ADP 0.00003607 0.43478 0.890208
2 1AQU A3P 0.002605 0.43801 1.0101
3 5WDR GNP 0.00000000561 0.73201 1.16959
4 4WEI GLC GAL 0.00574 0.42788 1.44404
5 1V8K ANP 0.00001869 0.52848 1.48368
6 1XKV ATP 0.00003976 0.51944 1.48368
7 1SVM ATP 0.001924 0.48042 1.48368
8 1F5N GNP 0.00003159 0.41133 1.48368
9 2A5J GDP 0.0000000003326 0.75954 1.57068
10 1YZN GNP 0.000000002743 0.74743 1.62162
11 3DKP ADP 0.00009869 0.49479 1.63265
12 2PL3 ADP 0.00008585 0.48784 1.69492
13 5XCO GDP 0.0000000003794 0.76127 1.75439
14 1R2Q GNP 0.000000002857 0.76428 1.76471
15 5FG3 GDP 0.0000000001279 0.74751 1.78042
16 4NCN GTP 0.00000001396 0.70378 1.78042
17 4TMZ GSP 0.00000001689 0.69973 1.78042
18 5GOE GDP 0.000000002717 0.66341 1.78042
19 2ZPA ADP 0.0000146 0.54858 1.78042
20 3P4X ADP 0.000008729 0.53195 1.78042
21 2Y65 ADP 0.000001262 0.52116 1.78042
22 2JLR ANP 0.00007437 0.50937 1.78042
23 1T5C ADP 0.000001041 0.50472 1.78042
24 2XAU ADP 0.000128 0.49542 1.78042
25 2QA1 FAD 0.03331 0.40594 1.78042
26 3MJH GTP 0.000000002838 0.74379 1.78571
27 2Z5F A3P 0.002926 0.43962 2.01342
28 5IRN ADP 0.000008486 0.55424 2.07715
29 2CE7 ADP 0.00002335 0.53038 2.07715
30 1OS1 PYR 0.0002482 0.50658 2.07715
31 1OS1 ATP 0.0002301 0.50658 2.07715
32 5LTJ ADP 0.00006651 0.50592 2.07715
33 1P9B GDP 0.0006008 0.46855 2.07715
34 1S7N COA 0.006347 0.4233 2.1978
35 5CK5 GDP 0.000000003472 0.68498 2.21519
36 1B0U ATP 0.00005814 0.51446 2.29008
37 2ZW5 COA 0.01142 0.41426 2.32558
38 1G6H ADP 0.0000009714 0.50483 2.33463
39 1EK0 GNP 0.00000000194 0.75195 2.35294
40 1H74 ADP 0.01391 0.42227 2.36486
41 1H74 ILE 0.02289 0.41004 2.36486
42 2ZPT A3P 0.02567 0.42537 2.37288
43 1GOJ ADP 0.0000001108 0.67873 2.37389
44 4H1V GNP 0.000007606 0.55943 2.37389
45 1QF5 GDP 0.002544 0.47583 2.37389
46 4PX9 ADP 0.00005663 0.51321 2.39726
47 4U00 ADP 0.0000006952 0.50956 2.45902
48 2ORV 4TA 0.003498 0.44285 2.5641
49 5GVR LMR 0.00002937 0.40451 2.5641
50 2X7I CIT 0.001575 0.43871 2.5974
51 3TKL GTP 0.000000001981 0.74845 2.62172
52 5KUT GDP 0.00000001308 0.67996 2.6455
53 3SFV GDP 0.000000001501 0.74435 2.67062
54 1DAR GDP 0.000000005628 0.6926 2.67062
55 1AZT GSP 0.000000157 0.66499 2.67062
56 1ZCB GDP 0.0000001695 0.65604 2.67062
57 4PPF FLC 0.000001333 0.62528 2.67062
58 3FVQ ATP 0.00007428 0.51694 2.67062
59 5GJC ATP 0.0000487 0.50909 2.67062
60 2ZR9 DTP 0.00005919 0.50515 2.67062
61 2FSH ANP 0.0005036 0.45323 2.67062
62 2GWH A3P 0.005889 0.42101 2.68456
63 1MH1 GNP 0.0000000994 0.48434 2.68817
64 1G4U GDP 0.0000001611 0.64287 2.71739
65 4LYA ATP 0.000007354 0.53228 2.86225
66 1EDO NAP 0.03309 0.40294 2.86885
67 1Z0A GDP 0.0000000005602 0.74883 2.87356
68 1D2N ANP 0.0005543 0.47465 2.94118
69 2R75 01G 0.0281 0.40188 2.95858
70 2FJU GSP 0.00000005528 0.66848 2.96736
71 3DC4 ADP 0.000008404 0.51787 2.96736
72 1XP8 AGS 0.0001721 0.47405 2.96736
73 4IEE AGS 0.000407 0.47221 2.96736
74 1PVN MZP 0.01555 0.42712 2.96736
75 4I4B NAD 0.0461 0.41479 2.96736
76 3RC3 ANP 0.007988 0.40033 2.96736
77 2GCN GDP 0.0000001225 0.65473 2.98507
78 2GCO GNP 0.00000012 0.64574 2.98507
79 2ZFI ADP 0.00001271 0.53628 3.00546
80 1F6B GDP 0.000000006423 0.69446 3.0303
81 1W4R TTP 0.0004235 0.49167 3.07692
82 3AFN NAP 0.01983 0.4155 3.10078
83 4WZ6 ATP 0.000008311 0.56908 3.10345
84 1OJ4 ANP 0.01153 0.40697 3.18021
85 4DKX GDP 0.000000001079 0.72603 3.24074
86 2C9O ADP 0.00001269 0.55411 3.2641
87 4HSE ADP 0.000006568 0.55313 3.2641
88 2AWN ADP 0.00000005955 0.52337 3.2641
89 3QKT ANP 0.0002116 0.50116 3.2641
90 5N69 ADP 0.00005111 0.46933 3.2641
91 4PJ3 ANP 0.0004436 0.43648 3.2641
92 4YS0 ADP 0.0002848 0.43567 3.2641
93 4ITM ATP 0.008572 0.42356 3.2641
94 2WKQ GTP 0.000000114 0.51233 3.31325
95 1RRC ADP 0.0000003875 0.53712 3.32226
96 1DS6 GDP 0.00000001235 0.67668 3.33333
97 1H65 GDP 0.000001093 0.60844 3.33333
98 1X1R GDP 0.000000004563 0.73646 3.37079
99 1L2T ATP 0.0001123 0.51468 3.40426
100 5X40 ACP 0.0001286 0.50974 3.42466
101 1RYH GNP 0.00000002345 0.67215 3.44828
102 3MGB PAP 0.00862 0.41683 3.44828
103 1JJ7 ADP 0.0000005623 0.51252 3.46154
104 1R0X ATP 0.0001594 0.4763 3.4965
105 2RCN GDP 0.000000002039 0.71315 3.56083
106 1Z6T ADP 0.000009157 0.55557 3.56083
107 3COB ADP 0.0000003018 0.54469 3.56083
108 1FNN ADP 0.00002313 0.53895 3.56083
109 1OXV ANP 0.00001261 0.52327 3.56083
110 2W58 ADP 0.0000004291 0.51666 3.56083
111 4OHY ANP 0.0001205 0.51318 3.56083
112 1IWE IMP 0.00179 0.51079 3.56083
113 1XMV ADP 0.00007744 0.50282 3.56083
114 3TBK ANP 0.00007899 0.48182 3.56083
115 5I34 GDP 0.0003079 0.47467 3.56083
116 1OYY AGS 0.001962 0.43426 3.56083
117 2RAB FAD 0.01847 0.42764 3.56083
118 5G41 AP5 0.0001883 0.53143 3.58744
119 1NJF ADP 0.0000148 0.54829 3.6
120 1NJF AGS 0.00002291 0.5441 3.6
121 4ZNL BEF ADP 0.00006692 0.48873 3.64964
122 1AE1 NAP 0.03471 0.40295 3.663
123 4NU0 AP5 0.00007838 0.54249 3.68664
124 4MKF AP5 0.0001062 0.53965 3.68664
125 1U0J ADP 0.0006657 0.44786 3.74532
126 2J0V GDP 0.00000001451 0.67784 3.77358
127 4QOS ADP 0.00004922 0.51506 3.77358
128 2KIN ADP 0.0000003746 0.52011 3.78151
129 2ZEJ GDP 0.0000000273 0.69791 3.80435
130 4GOX A3P 0.00007763 0.52048 3.83387
131 4NON GDP 0.00000003305 0.69636 3.84615
132 4B47 GDP 0.0000000002478 0.73556 3.85757
133 5TSH ANP 0.000007521 0.5469 3.85757
134 1K6M AGS 0.00002671 0.54315 3.85757
135 1F9V ADP 0.00000127 0.53882 3.85757
136 5TSH ADP 0.000005588 0.51144 3.85757
137 4XGU ADP 0.0001213 0.44857 3.85757
138 5J1J ANP 0.000004443 0.46361 3.85965
139 1P72 ADP 0.00004097 0.5493 3.89222
140 5EP2 AZU 0.01586 0.40393 3.90625
141 2Y8E GNP 0.000000009393 0.71811 3.91061
142 3WY9 GDP 0.0000000002158 0.73807 3.91705
143 3WYA GDP 0.0000000009791 0.728 3.91705
144 1XTQ GDP 0.000000003425 0.73364 3.9548
145 1KO8 6PG 0.00002914 0.53412 4
146 4P32 ADP 0.00009539 0.51393 4.01606
147 4YLG GDP 0.000000002522 0.72607 4.04624
148 1G3M PCQ 0.009381 0.43656 4.08163
149 2FFQ GSP 0.00000001865 0.70612 4.09357
150 4QM7 GTP 0.00001332 0.53534 4.09357
151 1J99 AND 0.01442 0.42146 4.09556
152 4GDX GLU 0.01096 0.41479 4.10256
153 1YZQ GNP 0.000000008126 0.72402 4.11765
154 1QF9 C5P 0.0004153 0.50395 4.12371
155 1D2E GDP 0.0000000004784 0.75648 4.1543
156 2C78 GNP 0.000000001191 0.75273 4.1543
157 2C77 GNP 0.000000002175 0.73654 4.1543
158 1SKQ GDP 0.000000001846 0.69676 4.1543
159 5M7P ADP 0.00006923 0.51602 4.1543
160 2D7D ADP 0.0003178 0.47112 4.1543
161 4IDN GNP 0.00009643 0.42378 4.1543
162 5BRE 4UZ 0.03242 0.40448 4.1543
163 1KAO GDP 0.000000001381 0.7386 4.19162
164 1IN4 ADP 0.00001789 0.54433 4.19162
165 4NE2 SH2 0.00007125 0.54321 4.19162
166 4NE2 ADP 0.00006237 0.54321 4.19162
167 4D81 ADP 0.00002284 0.48514 4.24028
168 5MVR ADP 0.00001253 0.53657 4.32099
169 3RWO GDP 0.000000003842 0.73729 4.32432
170 3IUY AMP 0.001666 0.43758 4.38596
171 4ZKD GDP 0.0000000009184 0.77101 4.45104
172 2BIF ANP 0.0000677 0.53985 4.45104
173 2BIF SIN 0.0001174 0.53985 4.45104
174 5HR5 ADP 0.00001973 0.53961 4.45104
175 3DZD ADP 0.0002149 0.48743 4.45104
176 3EZ2 ADP 0.00008818 0.48734 4.45104
177 5HR5 FLC 0.008891 0.43098 4.45104
178 3GJ3 GDP 0.00000000007225 0.78076 4.52489
179 3GJ5 GDP 0.0000000001271 0.77446 4.52489
180 3GJ4 GDP 0.0000000001635 0.76422 4.52489
181 1SQ5 ADP 0.0000114 0.5419 4.54545
182 1ZIN AP5 0.00004838 0.55604 4.60829
183 4MKG AP5 0.0001289 0.53403 4.60829
184 1BG2 ADP 0.0000004317 0.51823 4.61538
185 3FB4 AP5 0.00009005 0.54208 4.62963
186 2CBZ ATP 0.0000002421 0.66381 4.64135
187 1M2O GNP 0.0000001755 0.6553 4.73684
188 1SVK ALF GDP 0.0000002341 0.65854 4.74777
189 1TQ4 GDP 0.000000009999 0.57706 4.74777
190 5KDO GDP 0.0000004775 0.52284 4.74777
191 5FTB ANP 0.00005771 0.47948 4.74777
192 5FHD ADP ALF 0.00005003 0.43899 4.74777
193 1T8U UAP SGN IDS SGN 0.01379 0.42887 4.77941
194 1T8U A3P 0.005246 0.42732 4.77941
195 4R98 GNH 0.00000002518 0.66227 4.79705
196 1CLU DBG 0.00000001837 0.73662 4.81928
197 4YDS ATP 0.00001365 0.55128 4.82456
198 1Y3A GDP 0.0000003244 0.63691 4.86322
199 2WIC GNP 0.00000001999 0.6713 4.86891
200 2JAQ DCP 0.0008647 0.46924 4.87805
201 2OM2 GDP 0.0000001826 0.64334 4.92308
202 3CX8 GSP 0.0000001324 0.66869 4.92611
203 1UKZ ADP 0.0001539 0.52174 4.92611
204 1XEX ATP 0.0001101 0.5171 4.94506
205 3KTA AP5 0.0000607 0.51357 4.94506
206 2ODE ALF GDP 0.0000001986 0.65988 4.96454
207 3EWA ANP 0.00003246 0.5173 4.96894
208 4YMU ATP 0.00002213 0.53274 5
209 2F9L GDP 0.000000004826 0.72635 5.02513
210 1MKY GDP 0.0000000001879 0.76141 5.04451
211 2XTZ GSP 0.00000008955 0.66973 5.04451
212 2DPY ADP 0.00001425 0.55036 5.04451
213 5XDR ADP 0.0001363 0.47529 5.04451
214 2GK6 ADP 0.0004304 0.44836 5.04451
215 3T1O GDP 0.00000003039 0.66682 5.05051
216 1BH2 GSP 0.0000007651 0.63058 5.07937
217 1Z83 AP5 0.0002035 0.51558 5.10204
218 4BQS ADP 0.000003912 0.56013 5.11364
219 2ZE7 AMP 0.003182 0.44488 5.13834
220 2ZE7 DST 0.003425 0.44488 5.13834
221 2V2V V12 0.02263 0.4195 5.16605
222 4JLV ADP 0.00006459 0.49388 5.20446
223 1OE0 TTP 0.001734 0.45956 5.21739
224 2VF7 ADP 0.0000904 0.49966 5.22565
225 5SZH GNP 0.000000001584 0.75926 5.22876
226 1OIV GDP 0.000000002052 0.75075 5.2356
227 1OIX GDP 0.000000003165 0.74145 5.2356
228 3T5G GDP 0.0000000008783 0.7396 5.26316
229 1Z06 GNP 0.000000001807 0.75042 5.29101
230 4LJ9 ACP 0.0007228 0.45448 5.30973
231 4P4T GDP 0.0000006881 0.61249 5.34125
232 5JCP GDP ALF 0.0000002264 0.5526 5.34125
233 2Q2Y ADP 0.00017 0.5278 5.34125
234 2Q2Y MKR 0.0001655 0.52712 5.34125
235 4R43 GDP 0.00004404 0.51113 5.34125
236 2WHX ADP 0.000006201 0.50848 5.34125
237 3CNL GNP 0.000000007918 0.6688 5.34351
238 1I4D GDP 0.00000001314 0.65852 5.35714
239 1DAK DPU 0.0004121 0.51026 5.35714
240 3BD9 A3P 0.006697 0.4118 5.35714
241 3QXC ATP 0.000214 0.50468 5.3719
242 2B8T THM 0.003096 0.4403 5.38117
243 4D0N GDP 0.00000004596 0.65009 5.40541
244 5HPY GDP 0.000000115 0.64661 5.40541
245 3LXR GDP 0.00000006601 0.6039 5.40541
246 1E96 GTP 0.0000001353 0.66088 5.41872
247 3A1S GDP 0.00000007521 0.64428 5.42636
248 1KY3 GDP 0.0000000002244 0.77212 5.49451
249 1VHT BA3 0.0001418 0.49333 5.50459
250 1D5C GDP 0.000000002076 0.73012 5.55556
251 3GJX GTP 0.00000003738 0.69114 5.55556
252 3IIJ ADP 0.0000008925 0.59005 5.55556
253 1UJ2 ADP 0.000149 0.51248 5.55556
254 1UJ2 C5P 0.0001558 0.51152 5.55556
255 4KOT CE3 0.02288 0.41643 5.55556
256 4TTQ ATP 0.00001654 0.53095 5.5814
257 1Z0F GDP 0.0000000001754 0.76789 5.58659
258 5JCZ GDP 0.000000001027 0.62163 5.58659
259 2FH5 GTP 0.000000009836 0.7048 5.60748
260 5WRI A3P 0.0011 0.46222 5.625
261 5M04 GDP 0.00000000006534 0.76138 5.63798
262 5KSZ GCP 0.00000054 0.56728 5.63798
263 3ZFD ANP 0.00001578 0.53842 5.63798
264 2VVG ADP 0.0000001344 0.53715 5.63798
265 4FRZ ADP 0.000001822 0.53218 5.63798
266 1G41 ADP 0.00004758 0.51575 5.63798
267 4LX0 BEF GDP 0.00000000398 0.73941 5.64972
268 4XTR ADP 0.000005497 0.49041 5.65217
269 4XTR ATP 0.000007912 0.45741 5.65217
270 4XVU ATP 0.00001071 0.45291 5.65217
271 1PUJ GNP 0.000000001678 0.73054 5.67376
272 5E5U MLI 0.009879 0.43142 5.68182
273 1M7G ADX 0.00001306 0.57265 5.6872
274 1M7G AV2 0.000001045 0.57265 5.6872
275 1M7G ADP 0.00001537 0.56538 5.6872
276 3NKV GNP 0.000000002075 0.75051 5.71429
277 2A5F GTP 0.000000013 0.70827 5.71429
278 5K5Z ANP 0.00007745 0.41794 5.73248
279 4FCW ADP 0.0002812 0.47652 5.78778
280 1VG8 GNP 0.000000002464 0.74974 5.7971
281 1VG0 GDP 0.0000000007023 0.74854 5.7971
282 3R96 ACO 0.02175 0.41659 5.85106
283 3R96 AMP 0.02175 0.41659 5.85106
284 1Z08 GNP 0.00000005383 0.67509 5.88235
285 4GBM A3P 0.0004019 0.48553 5.88235
286 5MEX SZZ 0.01379 0.42685 5.90062
287 5MEX PAP 0.00572 0.4236 5.90062
288 4V0K GDP 0.000000009336 0.71534 5.91716
289 4KAX GTP 0.00000000842 0.71136 5.91716
290 1IHU ADP 0.000001515 0.60414 5.93472
291 2NCD ADP 0.000001689 0.60378 5.93472
292 1IHU AF3 0.000001464 0.60227 5.93472
293 4PFO ADP 0.00007863 0.52431 5.93472
294 1W5T ANP 0.0004202 0.48048 5.93472
295 1W5T ADP 0.0006675 0.46635 5.93472
296 4W93 3L9 0.02939 0.4056 5.93472
297 5WRJ A3P 0.001037 0.46721 5.94059
298 1VKJ A3P 0.005098 0.42792 5.96491
299 2ZTS ADP 0.00005198 0.44651 5.9761
300 1Q20 PLO 0.005874 0.44137 6.02007
301 3IO3 ADP 0.000005964 0.56731 6.03448
302 3QVV A3P 0.001456 0.47477 6.1017
303 3QVV 3QV 0.02185 0.4203 6.1017
304 1YRB GDP 0.00000000018 0.77668 6.10687
305 2PZE ATP 0.000001657 0.5143 6.11354
306 3N5C GDP 0.00000000214 0.71217 6.17284
307 3PCR GTP 0.00000001461 0.54735 6.17284
308 4QRH 0O2 0.001207 0.45827 6.19048
309 1GHE ACO 0.0195 0.40433 6.21469
310 4J0Q GDP 0.000000000125 0.74854 6.23145
311 1X6V ADP 0.00003713 0.54622 6.23145
312 2R42 FPS 0.006456 0.42294 6.23145
313 2GQT FAD 0.04855 0.41032 6.34328
314 2X77 GDP 0.000000002041 0.71784 6.34921
315 5L3V GDP 0.0000001227 0.59467 6.35452
316 3SBD GNP 0.0000001351 0.48978 6.41711
317 2W2X GSP 0.00000006901 0.66381 6.45161
318 1NST A3P 0.002464 0.43918 6.46154
319 1VG1 GDP 0.0000000003058 0.75656 6.48649
320 1VG9 GDP 0.0000000005688 0.7439 6.48649
321 5DI3 GNP 0.000000004387 0.57587 6.48649
322 3AQ4 GDP 0.00000000173 0.72121 6.52174
323 1WDT GTP 0.0000002223 0.53945 6.52819
324 4IOK ADP 0.0005616 0.48557 6.52819
325 4IOK XPO 0.0004552 0.48479 6.52819
326 1G7C 5GP 0.000000003303 0.70339 6.55022
327 5UFQ GNP 0.000000002904 0.7433 6.55738
328 3BC1 GNP 0.000000001227 0.76178 6.66667
329 5VGR GDP 0.00004486 0.46304 6.72854
330 3ZS9 ADP ALF 0.000007346 0.57734 6.77966
331 2WOJ ADP ALF 0.000007551 0.43543 6.77966
332 4CVN ADP 0.0000004838 0.57003 6.80628
333 1WA5 GTP 0.0000000255 0.70924 6.81818
334 5IRR GSP 0.000000936 0.4941 6.81818
335 3FKQ ATP 0.00000402 0.5727 6.82493
336 1NY5 ADP 0.00009667 0.50655 6.82493
337 5MZN ADP 0.0001948 0.49448 6.82493
338 3V2U ATP 0.004093 0.43439 6.82493
339 2O0J ADP 0.00291 0.4132 6.82493
340 3BER AMP 0.001446 0.44044 6.82731
341 2WMO GTP 0.0000001105 0.64032 6.84211
342 3W5J GDP 0.00000008068 0.5673 6.86275
343 1ION ADP 0.00002157 0.532 6.99588
344 3BOS CDP 0.0000795 0.49917 7.02479
345 1B7T ADP 0.00009051 0.50255 7.05128
346 4KVX ACO 0.02019 0.40647 7.05128
347 1Z0J GTP 0.000000003706 0.74095 7.05882
348 1W5F G2P 0.0149 0.41307 7.08215
349 1YVD GNP 0.000000002028 0.751 7.10059
350 5L3S GNP 0.0000003055 0.64085 7.12166
351 2XT3 ADP 0.0000003067 0.54412 7.12166
352 3ZIA ADP 0.00002794 0.52961 7.12166
353 3ZIA ATP 0.00002087 0.52955 7.12166
354 2OBM ADP 0.000002932 0.50532 7.12166
355 3WBD SIA SIA SIA SIA SIA SIA SIA 0.01173 0.40463 7.12166
356 1KK8 BEF ADP 0.00004282 0.52349 7.14286
357 1GUA GNP 0.000000009146 0.72148 7.18563
358 3NHB ADP 0.000006503 0.50851 7.18954
359 4AVB ACO 0.02181 0.40339 7.20721
360 4ITR GDP 0.0000001193 0.64916 7.27848
361 5HCN GCP 0.000000001635 0.69343 7.27969
362 3Q9L ATP 0.00004506 0.52243 7.30769
363 5J1S ATP 0.0002602 0.40317 7.31707
364 2BEK ATP 0.0005166 0.50037 7.393
365 4GOJ GNP 0.000000000315 0.78085 7.40741
366 1G7S GDP 0.000000000264 0.75955 7.40741
367 3U6B GDP 0.00000000003318 0.77359 7.4184
368 4G5G GDP 0.0000000001049 0.77321 7.4184
369 5JBQ GDP 0.000000000108 0.77262 7.4184
370 1D8T GDP 0.0000000001364 0.7679 7.4184
371 4P3Y GDP 0.00000000004788 0.76673 7.4184
372 2BVN GNP 0.0000000005387 0.75402 7.4184
373 3U6K GDP 0.0000000005277 0.74051 7.4184
374 4PC3 GDP 0.0000000003771 0.6786 7.4184
375 5I0H ADP BEF 0.00005462 0.52341 7.4184
376 4IHQ ADP 0.0000246 0.51116 7.4184
377 3BFX A3P 0.001276 0.45503 7.43243
378 2WJG GDP 0.000000004556 0.69687 7.44681
379 2HCJ GDP 0.00000000003303 0.77366 7.46269
380 4M9Q GNP 0.0000000009194 0.7582 7.48899
381 2CHG ANP 0.00004592 0.52204 7.52212
382 2BME GNP 0.000000001503 0.75743 7.52688
383 3SXN COA 0.01883 0.40196 7.58294
384 5IFS ADP 0.00003776 0.5205 7.59494
385 2ZFZ ARG 0.02961 0.44321 7.59494
386 1UPT GTP 0.000000002466 0.73733 7.60234
387 2QQ0 ANP 0.0001927 0.51527 7.6087
388 2QQ0 TMP 0.0002233 0.51203 7.6087
389 2QQ0 THM 0.0002168 0.50954 7.6087
390 3LRE ADP 0.0000002285 0.52879 7.71513
391 4ZG4 VO4 ADP 0.00005767 0.5268 7.71513
392 1W0J ADP 0.000009862 0.55113 7.72059
393 2CK3 ADP 0.0001126 0.51257 7.72059
394 1W0J ADP BEF 0.0001063 0.50704 7.72059
395 2CK3 ANP 0.0001222 0.50412 7.72059
396 1FZQ GDP 0.00000000004816 0.78897 7.73481
397 1MR3 G3D 0.000000000338 0.75451 7.73481
398 4HDO GNP 0.000000005979 0.73064 7.76398
399 4HDQ GNP 0.000000009627 0.72037 7.76398
400 3X1Z GNP 0.000000009228 0.50522 7.78443
401 1GWN GTP 0.0000004978 0.62224 7.80488
402 5L3W GDP 0.0000001115 0.64013 7.84314
403 1RE0 GDP 0.0000000005678 0.7206 7.92683
404 4HAT GNP 0.00000001326 0.71613 8.01187
405 3M1I GTP 0.00000001399 0.71232 8.01187
406 5UWP GNP 0.00000001641 0.71151 8.01187
407 5UWI GNP 0.00000001629 0.70904 8.01187
408 5UWR GNP 0.0000000169 0.70824 8.01187
409 5UWT GNP 0.00000002172 0.70284 8.01187
410 3WYF GTP 0.0000000398 0.69234 8.01187
411 5UWQ GNP 0.00000001382 0.51219 8.01187
412 5UWO GNP 0.00000001584 0.51059 8.01187
413 5DIF GNP 0.00000001585 0.51052 8.01187
414 5UWU GNP 0.00000001651 0.51049 8.01187
415 5UWW GNP 0.00000001704 0.51015 8.01187
416 5DHF GNP 0.00000001736 0.50986 8.01187
417 5UWJ GNP 0.00000001865 0.50875 8.01187
418 5UWH GNP 0.00000002074 0.50836 8.01187
419 2FAH GDP 0.00008476 0.50666 8.01187
420 5UWS GNP 0.0000000218 0.49831 8.01187
421 5DI9 GNP 0.00000002367 0.49787 8.01187
422 2QZ4 ADP 0.00002176 0.53182 8.01527
423 1ZJ6 G3D 0.000000002262 0.71575 8.02139
424 2B4D COA 0.01809 0.40114 8.18713
425 3KJI ADP 0.000005011 0.56513 8.26772
426 1KK1 GNP 0.0000000004167 0.72524 8.30861
427 4YC7 GNP 0.0000001521 0.65016 8.30861
428 4LPS GDP 0.00000009635 0.63923 8.30861
429 3RLF ANP 0.00005759 0.52682 8.30861
430 2I4I AMP 0.003038 0.40049 8.30861
431 2CJW GDP 0.0000000003628 0.74809 8.33333
432 3ZQ6 ADP ALF 0.000003792 0.59159 8.33333
433 1YZG GDP 0.000000003211 0.7086 8.37989
434 2WJH GDP 0.0000000005769 0.74361 8.43373
435 2WJH FLC 0.00000138 0.58846 8.43373
436 3A4M ADP 0.0000002568 0.58143 8.46154
437 1R4A GNP 0.000000001559 0.75357 8.48485
438 1W7J ADP BEF 0.00005077 0.51995 8.60927
439 3KUD GDP 0.000000002512 0.73351 8.64198
440 1M7B GTP 0.0000002017 0.52952 8.69565
441 5H67 ATP 0.002034 0.42347 8.75
442 1CR1 TTP 0.0000247 0.5401 8.78378
443 1TU3 GNP 0.000000002605 0.74563 8.86076
444 3Q85 GNP 0.00000000005417 0.78659 8.87574
445 4XOI GTP 0.0000004303 0.63353 8.88889
446 1HE1 GDP 0.00000006636 0.54362 8.88889
447 3AB3 GDP 0.00000005189 0.66981 8.94309
448 3E5H GNP 0.00000005242 0.68122 8.98876
449 3FYH ADP 0.00008727 0.52007 9.00621
450 4R2I ANP 0.0008036 0.4642 9.04762
451 2PZ8 APC 0.01243 0.41082 9.15493
452 1JI0 ATP 0.000008139 0.56232 9.16667
453 2HT6 GDP 0.0000000001374 0.74777 9.1954
454 4OI4 ATP 0.0004355 0.48382 9.19881
455 3FWY ADP 0.0000005347 0.61466 9.23567
456 1Y63 ADP 0.000001079 0.5862 9.23913
457 2C5L GTP 0.00000000431 0.73769 9.24856
458 5E95 GDP 0.0000000009228 0.63899 9.27835
459 4WOP CTP 0.00007994 0.4387 9.33333
460 1OFH ADP 0.00009085 0.50247 9.35484
461 4K81 GTP 0.000000005081 0.73689 9.35672
462 2EFE GNH 0.000000006382 0.70292 9.39227
463 2VB6 ADP BEF 0.0000643 0.52448 9.39597
464 2OZE AGS 0.00007467 0.51443 9.39597
465 1G16 GDP 0.000000001884 0.74302 9.41177
466 2EW1 GNP 0.0000000008709 0.76275 9.45274
467 1F2U ATP 0.0004142 0.49044 9.45946
468 4DCT GDP 0.0000000001989 0.76532 9.49555
469 1BO4 COA 0.005417 0.41366 9.52381
470 4U5X GNP 0.00000007419 0.65909 9.55056
471 1S8F GDP 0.000000001818 0.75913 9.60452
472 2UZI GTP 0.000000005373 0.7301 9.63855
473 3Q72 GNP 0.000000001242 0.70504 9.63855
474 3TMK T5A 0.00009035 0.5269 9.72222
475 1NN5 ANP 0.00006548 0.53735 9.76744
476 1NN5 2DT 0.03608 0.42368 9.76744
477 3GJ8 GDP 0.0000000001293 0.74016 9.78261
478 2IS6 ADP 0.0000393 0.51343 9.79228
479 4AUT FAD 0.04077 0.40421 9.79228
480 4DID GDP 0.00000005915 0.64918 9.86842
481 5KSP GDP 0.0000002652 0.59635 10
482 1KSH GDP 0.0000000008929 0.75527 10.089
483 4RD0 GDP 0.000000001249 0.75172 10.089
484 2QN6 GDP 0.0000000001549 0.74426 10.089
485 1YTM ATP 0.00006614 0.51938 10.089
486 2OFW ADX 0.00004429 0.55665 10.0962
487 1Z2A GDP 0.00000005105 0.53039 10.119
488 3T12 GDP ALF 0.00000009271 0.66063 10.2941
489 1S9D GDP 0.000000002146 0.71681 10.3448
490 4V03 ADP 0.000006676 0.55609 10.5058
491 1G3Q ADP 0.0000124 0.54017 10.5485
492 4BAS GNP 0.00000001358 0.70126 10.5528
493 4E03 ADP 0.00002165 0.52881 10.6796
494 3DOE GTP 0.000000002005 0.74503 10.6825
495 4A4Z ANP 0.002312 0.43093 10.6825
496 3BFV ADP 0.000003299 0.56358 10.7011
497 4KVG GTP 0.000000003131 0.74169 10.7143
498 1HTW ADP 0.00001466 0.53676 10.7595
499 3PQC GDP 0.000000004896 0.70431 10.7692
500 1XX6 ADP 0.0006731 0.45593 10.9948
501 3GJ7 GDP 0.0000000001115 0.77198 11.2245
502 3B7G ANP 0.00007774 0.50274 11.3043
503 4HUT ATP 0.02511 0.40561 11.5183
504 5LB3 ADP 0.00001613 0.53932 11.5727
505 2W83 GTP 0.00000001737 0.69913 11.6883
506 2PEZ DAT 0.00004071 0.54944 11.7318
507 1FP6 ADP 0.000002128 0.58283 11.7647
508 1FQJ GDP 0.0000001146 0.65903 11.9048
509 1S3G AP5 0.00008858 0.54245 11.9816
510 1CS4 GSP 0.0000002929 0.47441 12
511 3QF7 ANP 0.0001151 0.50539 12.1662
512 5BQ5 ADP BEF 0.00002812 0.49437 12.1693
513 2QTV GNP 0.0000003099 0.64054 12.2449
514 4WZA ADP 0.00001459 0.60405 12.3188
515 4WZA ACP 0.00001694 0.60055 12.3188
516 3T34 GDP 0.00001766 0.55195 12.4629
517 3UIE ANP 0.000004299 0.56513 12.5
518 3B5J 12D 0.00002677 0.49837 12.7572
519 2OG2 MLI 0.000003928 0.42925 12.7596
520 5TB5 GDP 0.0000000007499 0.74285 12.973
521 5TAR GDP 0.0000000006939 0.66323 12.973
522 4C4P GNP 0.000000001858 0.75582 13.0841
523 1ZUI SKM 0.00006235 0.54472 13.0952
524 4TMK T5A 0.001385 0.47328 13.1455
525 4LHW GNP 0.000000002313 0.74818 13.2184
526 3TNF GNP 0.000000003818 0.74307 13.2184
527 3QBT GNP 0.000000001342 0.54651 13.2184
528 2HF9 GSP 0.000001353 0.52888 13.2743
529 2BCG GDP 0.0000000006606 0.75786 13.3531
530 3CPJ GDP 0.0000000008544 0.74449 13.3531
531 1JJV ATP 0.000007717 0.50916 13.5922
532 4DSU GDP 0.000000002628 0.74835 13.7566
533 2C04 GCP 0.000004641 0.50808 13.8047
534 1NRJ GTP 0.000001335 0.60148 14.2202
535 3B9Q MLI 0.00001226 0.43507 14.2384
536 4ZI2 GNP 0.0000000001463 0.61582 14.2857
537 3WYG GTP 0.00000008035 0.67714 14.4737
538 5EE5 GTP 0.000000002366 0.73821 14.5401
539 4XSH GSP 0.0000001122 0.54996 14.6119
540 5L3R GCP 0.000000213 0.50004 14.6758
541 1E2K TMC 0.0000426 0.5589 14.8036
542 3DEF GDP 0.0000001477 0.63797 14.8855
543 2A9K GDP 0.000000002349 0.72755 14.9733
544 3H86 AP5 0.00003008 0.55935 15.1042
545 2V7Q ATP 0.000006508 0.55661 15.1515
546 2V7Q ADP 0.00008129 0.49872 15.1515
547 3H4S ADP 0.0000003916 0.5393 15.5556
548 1UAD GNP 0.000000008551 0.72013 16
549 4BFW ZVW 0.0001861 0.52577 16.3522
550 1ZD9 GDP 0.00000005244 0.66635 16.4894
551 1U8Z GDP 0.000000008093 0.71536 16.6667
552 1LVG ADP 0.0000002766 0.58257 16.6667
553 3E70 GDP 0.0000002899 0.61677 16.7683
554 5UQW GDP 0.000000001131 0.76042 16.9312
555 2RGX AP5 0.0001896 0.5278 17.4757
556 4RZ3 ADP 0.000008265 0.5577 17.9661
557 2J59 GTP 0.00000001049 0.70985 18.0723
558 1O3Y GTP 0.00000001472 0.70265 18.0723
559 1J2J GTP 0.00000001851 0.69778 18.0723
560 2F3R G5P 0.003493 0.45157 18.8406
561 5O2T GSP 0.000000004141 0.52447 18.9349
562 3VMF GTP 0.000000001886 0.75256 19.8813
563 3WXM GTP 0.000000004035 0.73624 19.8813
564 4D0G GTP 0.0000000006158 0.76668 20.2899
565 3CH5 GDP 0.0000000001601 0.76975 21.1538
566 1ZC3 GNP 0.000000004863 0.73509 22.2857
567 2QG6 NMN 0.0002193 0.50592 23.1156
568 1RJ9 GCP 0.000001354 0.64094 23.6842
569 3DDC GNP 0.000000003073 0.74498 23.9264
570 2IYL GDP 0.0000002535 0.61552 25.3521
571 5H56 ADP 0.00001737 0.5646 30.7692
572 5H56 TYD 0.00001737 0.5646 30.7692
573 2IL4 COA 0.001456 0.44787 32.0388
574 1GXU 2HP 0.00001597 0.41258 32.967
575 1Z0K GTP 0.0000000009285 0.76139 33.3333
576 4HI0 GDP 0.0000004815 0.62294 35.1759
Pocket No.: 2; Query (leader) PDB : 4LC1; Ligand: GDP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4lc1.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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