Receptor
PDB id Resolution Class Description Source Keywords
4NCN 1.87 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF EUKARYOTIC TRANSLATION INITIATION FACTO (517-858) FROM CHAETOMIUM THERMOPHILUM IN COMPLEX WITH GTP CHAETOMIUM THERMOPHILUM VAR. THERMOPHIORGANISM_TAXID: 759272 TRANSLATION INITIATION GTPASE EIF5B/IF2 SUBUNIT JOINING TRANSLATION
Ref.: EIF5B EMPLOYS A NOVEL DOMAIN RELEASE MECHANISM TO C RIBOSOMAL SUBUNIT JOINING. EMBO J. V. 33 1177 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GTP A:1001;
B:1001;
Valid;
Valid;
none;
none;
submit data
523.18 C10 H16 N5 O14 P3 c1nc2...
GOL B:1006;
B:1005;
A:1006;
A:1004;
A:1005;
B:1007;
B:1008;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
NA A:1003;
B:1003;
Part of Protein;
Part of Protein;
none;
none;
submit data
22.99 Na [Na+]
MG A:1002;
B:1002;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
ACY B:1004;
Invalid;
none;
submit data
60.052 C2 H4 O2 CC(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4NCN 1.87 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF EUKARYOTIC TRANSLATION INITIATION FACTO (517-858) FROM CHAETOMIUM THERMOPHILUM IN COMPLEX WITH GTP CHAETOMIUM THERMOPHILUM VAR. THERMOPHIORGANISM_TAXID: 759272 TRANSLATION INITIATION GTPASE EIF5B/IF2 SUBUNIT JOINING TRANSLATION
Ref.: EIF5B EMPLOYS A NOVEL DOMAIN RELEASE MECHANISM TO C RIBOSOMAL SUBUNIT JOINING. EMBO J. V. 33 1177 2014
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 257 families.
1 4NCN - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
2 4NCL - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 222 families.
1 4NCN - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
2 4NCL - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 4TMX - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
4 4TMZ Kd = 0.92 uM GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
5 4TMV - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
6 4TMT - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
7 4TMW Kd = 4.1 uM GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 185 families.
1 4NCN - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
2 4NCL - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 4TMX - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
4 4TMZ Kd = 0.92 uM GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
5 4TMV - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
6 4TMT - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
7 4TMW Kd = 4.1 uM GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GTP; Similar ligands found: 147
No: Ligand ECFP6 Tc MDL keys Tc
1 GTP 1 1
2 GP3 0.921053 0.973684
3 GDP 0.909091 1
4 GSP 0.853659 0.948718
5 GNH 0.82716 0.986667
6 G1R 0.819277 0.986667
7 GAV 0.811765 0.961039
8 GNP 0.809524 0.973684
9 GCP 0.797619 0.973684
10 5GP 0.797468 0.986486
11 G 0.797468 0.986486
12 GMV 0.764706 0.973684
13 G2R 0.764045 0.961039
14 G5P 0.755319 0.973684
15 GTG 0.752688 0.936709
16 G2P 0.747126 0.961039
17 G3A 0.744681 0.973684
18 GDD 0.741935 0.961039
19 GKE 0.741935 0.961039
20 GDC 0.741935 0.961039
21 0O2 0.736264 0.986486
22 GP2 0.729412 0.961039
23 6CK 0.726316 0.936709
24 Y9Z 0.723404 0.902439
25 GPG 0.717391 0.961039
26 GFB 0.715789 0.961039
27 GDR 0.715789 0.961039
28 GDP MG 0.712644 0.923077
29 GDP BEF 0.704545 0.9
30 GPD 0.704082 0.925
31 JB2 0.693878 0.961039
32 GKD 0.693878 0.961039
33 GCP G 0.692308 0.935065
34 GDX 0.686869 0.973684
35 ALF 5GP 0.685393 0.888889
36 GTP MG 0.681319 0.923077
37 BEF GDP 0.681319 0.888889
38 GH3 0.681319 0.973333
39 YGP 0.677083 0.901235
40 G3D 0.67033 0.986486
41 GDP AF3 0.659574 0.888889
42 GDP ALF 0.659574 0.888889
43 DGT 0.659341 0.923077
44 GMP 0.658228 0.88
45 G4P 0.655914 0.986486
46 JB3 0.653846 0.948718
47 NGD 0.647619 0.961039
48 CAG 0.642202 0.880952
49 2MD 0.62963 0.891566
50 G G 0.622449 0.935065
51 MGP 0.619565 0.961039
52 U2G 0.616822 0.936709
53 6G0 0.612903 0.961039
54 MGD 0.612613 0.891566
55 TPG 0.608696 0.840909
56 CG2 0.605505 0.936709
57 GDP 7MG 0.601942 0.911392
58 FEG 0.601852 0.879518
59 ZGP 0.59633 0.869048
60 MD1 0.591304 0.891566
61 PGD 0.591304 0.925
62 3GP 0.590909 0.946667
63 GPX 0.581633 0.946667
64 DGI 0.580645 0.923077
65 IDP 0.576087 0.972973
66 DBG 0.567797 0.948718
67 FE9 0.555556 0.776596
68 2GP 0.555556 0.96
69 G4M 0.547619 0.880952
70 BGO 0.544643 0.924051
71 I2C FE2 CMO CMO 0.538462 0.808989
72 ATP 0.537634 0.92
73 G1G 0.533898 0.925
74 AQP 0.531915 0.92
75 5FA 0.531915 0.92
76 G A A A 0.525862 0.923077
77 U A G G 0.521368 0.935065
78 01G 0.518868 0.902439
79 ITT 0.510638 0.868421
80 P2G 0.510638 0.883117
81 GGM 0.504274 0.901235
82 G1R G1R 0.504065 0.924051
83 DGP 0.5 0.910256
84 PGD O 0.5 0.850575
85 MGO 0.5 0.864198
86 P1G 0.5 0.871795
87 DG 0.5 0.910256
88 GTA 0.495495 0.936709
89 B4P 0.489362 0.894737
90 AP5 0.489362 0.894737
91 IMP 0.489362 0.959459
92 7DT 0.484536 0.906667
93 G G U 0.482143 0.935065
94 GPC 0.479339 0.879518
95 G C 0.478992 0.9
96 BA3 0.478723 0.894737
97 ADP 0.473684 0.92
98 G2Q 0.471698 0.961039
99 G7M 0.46875 0.948052
100 25L 0.458716 0.907895
101 A2D 0.457447 0.894737
102 RGT 0.45045 0.909091
103 AGS 0.45 0.873418
104 SAP 0.45 0.873418
105 SGP 0.44898 0.82716
106 U G A 0.448529 0.888889
107 A4P 0.445378 0.869048
108 G G G RPC 0.442623 0.875
109 ACQ 0.441176 0.896104
110 ANP 0.441176 0.896104
111 8GT 0.441176 0.875
112 APC G U 0.44 0.886076
113 G U34 0.438017 0.888889
114 6AD 0.436893 0.841463
115 G G G C 0.433071 0.9125
116 UP5 0.432203 0.873418
117 35G 0.431373 0.933333
118 C2E 0.431373 0.921053
119 PCG 0.431373 0.933333
120 A G C C 0.429688 0.911392
121 5GP 5GP 0.427184 0.883117
122 TAT 0.427184 0.884615
123 APR 0.425743 0.894737
124 AR6 0.425743 0.894737
125 AN2 0.424242 0.907895
126 7DD 0.424242 0.906667
127 DG DG 0.423423 0.865854
128 AD9 0.421569 0.896104
129 M33 0.42 0.883117
130 7D4 0.42 0.835443
131 UCG 0.419847 0.911392
132 H6Y 0.419048 0.946667
133 G C C C 0.416667 0.924051
134 ACP 0.415842 0.896104
135 T5A 0.414634 0.802326
136 MGQ 0.412844 0.935897
137 ADQ 0.412844 0.871795
138 A1R 0.412844 0.839506
139 MGT 0.411215 0.823529
140 A G U 0.410072 0.888889
141 93A 0.41 0.833333
142 A22 0.407407 0.907895
143 CA0 0.405941 0.896104
144 ATF 0.40566 0.884615
145 AGO 0.404762 0.888889
146 MGV 0.401786 0.890244
147 CGP 0.4 0.86747
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4NCN; Ligand: GTP; Similar sites found: 497
This union binding pocket(no: 1) in the query (biounit: 4ncn.bio2) has 24 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4IDN GNP 0.00002404 0.50245 1.31291
2 5XDR ADP 0.001817 0.44847 1.31291
3 3VM7 GLC 0.01221 0.42869 1.31291
4 1V8K ANP 0.000002386 0.5945 1.46341
5 1ION ADP 0.0002932 0.41998 1.64609
6 3MD0 GDP 0.000000003604 0.74497 1.69014
7 1GOJ ADP 0.000001408 0.64241 1.69014
8 3ZFD ANP 0.0000001177 0.53752 1.7094
9 5HR5 ADP 0.0008281 0.41355 1.75055
10 4LC1 GDP 0.00000001396 0.70378 1.78042
11 2AWN ADP 0.000007504 0.61219 1.83727
12 2RCN GDP 0.0000000004495 0.59124 1.95531
13 1G41 ADP 0.0002866 0.48123 1.96937
14 1OYY AGS 0.003369 0.4403 1.96937
15 2WOJ ADP ALF 0.0001108 0.44927 1.9774
16 5L3V GDP 0.000009552 0.47544 2.00669
17 2CJW GDP 0.0000000001237 0.80423 2.08333
18 4D81 ADP 0.0008759 0.40459 2.12014
19 1JI0 ATP 0.0001223 0.52479 2.18818
20 1XP8 AGS 0.0003939 0.49208 2.18818
21 3QF7 ANP 0.002642 0.42439 2.19178
22 4P4T GDP 0.000004596 0.5446 2.22222
23 3DEF GDP 0.00001094 0.54066 2.29008
24 1QF5 RPL 0.009804 0.44445 2.32019
25 4FRZ ADP 0.00001455 0.41786 2.33161
26 4R43 GDP 0.0007194 0.47315 2.39617
27 4PFO ADP 0.0001197 0.47278 2.407
28 1DNP MHF 0.01655 0.41667 2.407
29 1TQ4 GDP 0.0000001727 0.59942 2.42131
30 2ZFI ADP 0.00005122 0.52932 2.45902
31 2Y65 ADP 0.000003074 0.42513 2.46575
32 3QXC ATP 0.0009502 0.4148 2.47934
33 3FVQ ATP 0.0008764 0.44088 2.50696
34 1K6M AGS 0.003771 0.40714 2.5463
35 1W0J ADP 0.00005518 0.45057 2.57353
36 1W0J ADP BEF 0.001469 0.40864 2.57353
37 2ZR9 DTP 0.0001738 0.50334 2.5788
38 1OFH ADP 0.0001105 0.4327 2.58065
39 1H65 GDP 0.0000991 0.47666 2.59259
40 2C9O ADP 0.0006499 0.44644 2.63158
41 2C04 GCP 0.0001079 0.48988 2.6936
42 1Y63 ADP 0.00004578 0.5317 2.71739
43 5X40 ACP 0.002611 0.41372 2.73973
44 4HSE ADP 0.0003459 0.4829 2.77078
45 1UJ2 C5P 0.0008141 0.43989 2.77778
46 1UJ2 ADP 0.002919 0.4167 2.77778
47 4P32 ADP 0.00566 0.40296 2.81124
48 1F5N GNP 0.000001566 0.51762 2.84464
49 3BFV ADP 0.0001061 0.51383 2.84464
50 2VF7 ADP 0.0003369 0.40406 2.84464
51 4U60 SIA 0.02272 0.40556 2.85714
52 4GOX A3P 0.001961 0.41883 2.8754
53 2PL3 ADP 0.000451 0.48912 2.9661
54 4B9E FAH 0.01227 0.42526 2.99003
55 2XTN GTP 0.000002884 0.53526 2.99145
56 3B7G ANP 0.001015 0.46056 3.04348
57 2ZPA ADP 0.0005695 0.42395 3.06346
58 1R6B ADP 0.0001814 0.41905 3.06346
59 4YDS ATP 0.00006864 0.53772 3.07018
60 1BG2 ADP 0.0000005451 0.4281 3.07692
61 1FNN ADP 0.0008494 0.44558 3.08483
62 5MVR ADP 0.00008413 0.42032 3.08642
63 4V03 ADP 0.0001837 0.42375 3.11284
64 2VVG ADP 0.000002132 0.4158 3.14286
65 1R0X ATP 0.0001412 0.4034 3.14685
66 1VHT BA3 0.000833 0.4596 3.21101
67 2Q2Y ADP 0.001232 0.44871 3.26975
68 2Q2Y MKR 0.00137 0.44553 3.26975
69 4A4Z ANP 0.001311 0.46039 3.28228
70 2ZJ5 ADP 0.01795 0.41451 3.28228
71 1ZCB GDP 0.0000002424 0.58473 3.31492
72 1MR3 G3D 0.000000005499 0.57239 3.31492
73 5JCP GDP ALF 0.0000000002846 0.73885 3.34129
74 3E70 GDP 0.00001813 0.46 3.35366
75 2OZE AGS 0.0004647 0.42859 3.3557
76 5LB3 ADP 0.0003048 0.40029 3.37079
77 3ZQ6 ADP ALF 0.00005528 0.4887 3.39506
78 2V7Q ATP 0.00003758 0.5224 3.42466
79 2V7Q ADP 0.0002583 0.49493 3.42466
80 2CK3 ANP 0.001404 0.43604 3.42466
81 2CK3 ADP 0.001762 0.42075 3.42466
82 2JFV FLC 0.0284 0.40778 3.43643
83 3IO3 ADP 0.0006539 0.4225 3.44828
84 2W58 ADP 0.000004837 0.61947 3.46535
85 5VGR GDP 0.0008037 0.45096 3.48028
86 3DC4 ADP 0.00001451 0.57249 3.48837
87 3FKQ ATP 0.0001701 0.48107 3.50109
88 3FWY ADP 0.0000732 0.45172 3.50318
89 1LVG ADP 0.000006724 0.43543 3.53535
90 4XGU ADP 0.0003688 0.46606 3.53774
91 4WOP CTP 0.00013 0.45619 3.55556
92 3TKL GTP 0.000000000005829 0.7505 3.57143
93 2J59 GTP 0.00000000002287 0.7449 3.61446
94 1O3Y GTP 0.00000000003519 0.73721 3.61446
95 4ZNL BEF ADP 0.00008328 0.42598 3.64964
96 3AB3 GDP 0.0000001191 0.57569 3.65854
97 1SVK ALF GDP 0.000000001378 0.6893 3.68272
98 3BFX A3P 0.008937 0.40085 3.71622
99 4ZG4 VO4 ADP 0.000001673 0.54498 3.71991
100 4E3Q PMP 0.007719 0.42263 3.71991
101 5TSH ANP 0.0001117 0.41731 3.71991
102 1P4V GLY 0.009314 0.42917 3.72881
103 4PX9 ADP 0.0003988 0.40357 3.76712
104 4WZ6 ATP 0.00003667 0.55929 3.7931
105 3COB ADP 0.000002634 0.4282 3.79404
106 3AQ4 GDP 0.000000003442 0.72185 3.80435
107 3QKT ANP 0.001912 0.42106 3.83481
108 1G6H ADP 0.000005927 0.61369 3.89105
109 2FNA ADP 0.0005883 0.44423 3.92157
110 3CX8 GSP 0.000000000296 0.63243 3.93873
111 5LTJ ADP 0.0003176 0.41027 3.93873
112 1QHG ATP 0.01207 0.40174 3.93873
113 1G6O ADP 0.0003148 0.47932 3.93939
114 1UKZ ADP 0.0087 0.40477 3.94089
115 1Y3A GDP 0.0000007944 0.55828 3.95137
116 2B8W ALF 5GP 0.000001126 0.55458 3.96341
117 1W7J ADP BEF 0.00001855 0.52401 3.97351
118 3NKV GNP 0.000000000006975 0.72961 4
119 1FQK ALF 0.0000005092 0.66375 4
120 4PPF FLC 0.000006493 0.59924 4
121 1FQK GDP 0.000000242 0.5795 4
122 2NCD ADP 0.00002157 0.56941 4.04762
123 4AG5 ADP 0.00007442 0.5406 4.08163
124 2FFQ GSP 0.000000000001406 0.80599 4.09357
125 1SVI GDP 0.0000000004069 0.58095 4.10256
126 1YZQ GNP 0.000000000001269 0.80785 4.11765
127 1BH2 GSP 0.000000001373 0.61054 4.12698
128 5MZN ADP 0.001339 0.47122 4.15755
129 2FAH GDP 0.0006789 0.4147 4.15755
130 1XKV ATP 0.0005385 0.40939 4.15755
131 1BO4 COA 0.0173 0.40538 4.16667
132 1NN5 ANP 0.002412 0.42608 4.18605
133 3Q72 GNP 0.00000000005173 0.60158 4.21687
134 1G3Q ADP 0.0001804 0.4964 4.21941
135 2IYL GDP 0.00005024 0.52973 4.22535
136 5J1S ATP 0.000198 0.46177 4.22535
137 1L2T ATP 0.001697 0.41479 4.25532
138 3R7F CP 0.01788 0.41418 4.27632
139 2OBM ADP 0.003044 0.45824 4.32277
140 1YZN GNP 0.000000000003089 0.72657 4.32432
141 2OFW ADX 0.001443 0.44455 4.32692
142 1IHU AF3 0.0006249 0.44313 4.37637
143 1IHU ADP 0.0006945 0.43737 4.37637
144 5IRN ADP 0.0002251 0.42699 4.37637
145 1AZT GSP 0.0000000004407 0.62699 4.47761
146 5KSZ GCP 0.0000004955 0.51718 4.48113
147 4U5X GNP 0.0000000001557 0.67489 4.49438
148 1FP6 ADP 0.0003545 0.47174 4.49827
149 3TK1 GDP 0.000000005708 0.74795 4.54545
150 1YRB GDP 0.0000000008415 0.72833 4.58015
151 1T5C ADP 0.000001865 0.41586 4.58453
152 2CE7 ADP 0.0002942 0.41421 4.59519
153 4MKG AP5 0.00429 0.4249 4.60829
154 3TKA CTN 0.009562 0.43563 4.61095
155 4IOK ADP 0.003909 0.4129 4.65116
156 4IOK XPO 0.003163 0.412 4.65116
157 4QM7 GTP 0.0002329 0.40615 4.67836
158 3H86 AP5 0.001567 0.43811 4.6875
159 4WEI GLC GAL 0.002882 0.45917 4.69314
160 4WZA ADP 0.00007192 0.52244 4.71014
161 4WZA ACP 0.00007192 0.52244 4.71014
162 3KJI ADP 0.0004212 0.42176 4.72441
163 3RAB GNP 0.000000000004797 0.78021 4.73373
164 1M7G ADX 0.0003022 0.4645 4.73934
165 1M7G ADP 0.0004185 0.45533 4.73934
166 1M7G AV2 0.000004522 0.44989 4.73934
167 5CK5 GDP 0.000000004213 0.55344 4.74684
168 1G8S MET 0.0108 0.42815 4.78261
169 1YQT ADP 0.0001202 0.53097 4.814
170 3CV2 OXL 0.0119 0.41454 4.814
171 3NHB ADP 0.00007681 0.54151 4.90196
172 2DPY ADP 0.001768 0.46501 5.02283
173 2PEZ GGZ 0.001836 0.4325 5.02793
174 2PEZ DAT 0.001836 0.4325 5.02793
175 5I0H ADP BEF 0.0000004808 0.55038 5.03282
176 4LYA ATP 0.000237 0.49074 5.03282
177 2BIF ANP 0.002255 0.43 5.03282
178 2BIF SIN 0.003859 0.43 5.03282
179 2CBZ ATP 0.000003475 0.62807 5.06329
180 4MKF AP5 0.006024 0.41944 5.06912
181 5FTB ANP 0.000262 0.48305 5.08083
182 5FHD ADP ALF 0.0003851 0.45617 5.08083
183 1NJF AGS 0.0007375 0.43094 5.2
184 1NJF ADP 0.001003 0.41458 5.2
185 1PSC EBP 0.003547 0.40296 5.20548
186 3SFV GDP 0.00000002112 0.60236 5.23256
187 5BQ5 ADP BEF 0.0005522 0.46793 5.29101
188 3Q85 GNP 0.0000000001929 0.60061 5.32544
189 3EZ2 ADP 0.001072 0.47024 5.52764
190 5N69 ADP 0.00002367 0.45917 5.52764
191 2G77 GDP 0.0000000001762 0.74815 5.55556
192 2G77 AF3 0.0000002973 0.66785 5.55556
193 5L3W GDP 0.00006841 0.44554 5.55556
194 3FB4 AP5 0.005954 0.41863 5.55556
195 4OHY ANP 0.0001437 0.45819 5.56845
196 3E5H GNP 0.00000000007316 0.73103 5.61798
197 5H56 ADP 0.003078 0.42018 5.64103
198 5H56 TYD 0.003078 0.42018 5.64103
199 2XTZ GSP 0.0000000001376 0.71963 5.64972
200 4KFU ACP 0.000003874 0.43617 5.66038
201 1JWY GDP 0.000001423 0.58107 5.68928
202 1JWY ADP 0.00001444 0.5488 5.68928
203 5L3S GNP 0.00001307 0.51057 5.74324
204 3B5J 12D 0.00006102 0.54035 5.76132
205 1Z06 GNP 0.000000000002153 0.76809 5.82011
206 2X77 GDP 0.000000001056 0.74637 5.82011
207 5G41 AP5 0.008303 0.41706 5.8296
208 5M04 GDP 0.0000000003913 0.58426 5.83333
209 3T34 GDP 0.000008874 0.5152 5.83333
210 5IRR GSP 0.00000006394 0.61041 5.84416
211 3EWA ANP 0.00009066 0.41395 5.90062
212 2IXE ATP 0.0005537 0.44533 5.90406
213 4H1V GNP 0.00001001 0.53597 5.9081
214 5IFS ADP 0.000243 0.41757 5.9081
215 2F9L GDP 0.00000002161 0.62261 6.03015
216 2VB6 ADP BEF 0.00006514 0.47962 6.04027
217 4FCW ADP 0.0006838 0.40042 6.10932
218 3DKP ADP 0.0006295 0.47599 6.12245
219 4YS0 ADP 0.002638 0.42791 6.12691
220 3REF GDP 0.000000007191 0.65019 6.18557
221 3LRE ADP 0.000005659 0.60612 6.19718
222 1DS6 GDP 0.000000002633 0.56726 6.25
223 4YMU ATP 0.00009365 0.40561 6.25
224 1OIX GDP 0.00000000008994 0.72731 6.28272
225 1OIV GDP 0.000000009022 0.64413 6.28272
226 3TNF GNP 0.000000000006381 0.78189 6.32184
227 4LHW GNP 0.00000000006619 0.69349 6.32184
228 4YLG GDP 0.000000005614 0.60401 6.35838
229 1ZD9 GDP 0.00000004041 0.63441 6.38298
230 2GK6 ADP 0.002474 0.45748 6.41026
231 3BER AMP 0.01839 0.40406 6.4257
232 1KSH GDP 0.000000000002637 0.75647 6.45161
233 4DKX GDP 0.00000000003775 0.82946 6.48148
234 3RWO GDP 0.000000004359 0.65726 6.48649
235 4V0K GDP 0.000000126 0.57901 6.50888
236 3RC3 ANP 0.002182 0.45474 6.56455
237 3I7S PYR 0.0127 0.42814 6.56455
238 2W83 GTP 0.00000000001958 0.74767 6.66667
239 1Z0F GDP 0.00000000009836 0.79561 6.70391
240 5JCZ GDP 0.000000001193 0.70123 6.70391
241 4LX0 BEF GDP 0.000000000004122 0.78647 6.77966
242 4Q1A 2XZ 0.003367 0.4787 6.78337
243 4Q1A UDP 0.003367 0.4787 6.78337
244 2OAT PFM 0.005448 0.41383 6.83371
245 1B0U ATP 0.002195 0.4356 6.87023
246 4C4P GNP 0.00000000003796 0.74619 6.93642
247 3N7S 3N7 0.008117 0.43648 6.95652
248 4OI4 ATP 0.0007755 0.4354 6.95652
249 2OG2 MLI 0.000201 0.51784 6.96379
250 2HV8 GTP 0.00000000005638 0.73574 6.97674
251 3UIE ANP 0.0001645 0.49248 7
252 2KIN ADP 0.0000008873 0.42381 7
253 4BAS GNP 0.00000000007764 0.71195 7.03518
254 2HF9 GSP 0.0000001933 0.61246 7.07965
255 1TAD ALF 0.000000001041 0.69178 7.09877
256 1TAD GDP 0.000000001041 0.69178 7.09877
257 2D7C GTP 0.00000000006058 0.73444 7.18563
258 2GDJ ANP 0.000131 0.50935 7.19697
259 1P9B GDP 0.0001491 0.48361 7.22101
260 5I34 GDP 0.00004097 0.4454 7.25624
261 2XT3 ADP 0.00000437 0.61039 7.26744
262 4ZI2 GNP 0.000000000001842 0.77661 7.36842
263 4GOJ GNP 0.000000000001594 0.77908 7.40741
264 1APZ ASP 0.01799 0.41291 7.40741
265 4D0G GTP 0.00000000008713 0.70893 7.42857
266 1SQ5 ADP 0.0003256 0.48416 7.46753
267 2FH5 GTP 0.000000000002206 0.80879 7.47664
268 1ZJ6 G3D 0.000000001193 0.74384 7.48663
269 3Q9L ATP 0.0001079 0.48988 7.69231
270 1GXU 2HP 0.006666 0.4073 7.69231
271 5J1J ANP 0.0001123 0.46989 7.7193
272 1D2N ANP 0.00397 0.41278 7.72059
273 1FZQ GDP 0.0000000003962 0.77949 7.73481
274 2Y8E GNP 0.000000000002999 0.74313 7.82123
275 4ZKD GDP 0.0000000000166 0.76119 7.87746
276 3MJH GTP 0.000000000003084 0.7437 7.87746
277 5K5Z ANP 0.0008006 0.43669 7.96178
278 5GOE GDP 0.000000003327 0.71153 8.05687
279 3WYA GDP 0.000000000127 0.80367 8.06452
280 3CPJ GDP 0.000000006885 0.58948 8.07175
281 2GJ8 ALF GDP 0.0000000000923 0.67337 8.13953
282 1PUJ GNP 0.0000000002677 0.64149 8.15603
283 1G16 GDP 0.00000002079 0.61384 8.23529
284 1JJV ATP 0.00005687 0.5474 8.25243
285 3B9Q MLI 0.0001605 0.52125 8.27815
286 4XTR ATP 0.0006844 0.43763 8.29493
287 4XVU ATP 0.0007468 0.43607 8.29493
288 4XTR ADP 0.0006161 0.42409 8.29493
289 1Z6T ADP 0.001294 0.44173 8.3151
290 1F9V ADP 0.00001698 0.41674 8.35735
291 1YZG GDP 0.000000001234 0.59261 8.37989
292 1GP2 GDP 0.000001835 0.54334 8.4507
293 5L3R GCP 0.000002935 0.52511 8.53242
294 2IS6 ADP 0.0001727 0.50349 8.53392
295 2QEN ADP 0.0003375 0.42688 8.57143
296 3BC1 GNP 0.00000000001111 0.76505 8.71795
297 4E03 ADP 0.0001736 0.42343 8.73786
298 2QZ4 ADP 0.0002738 0.48215 8.77863
299 4TTQ ATP 0.00008778 0.51787 8.83721
300 2WKQ GTP 0.0000000002854 0.69985 9.03614
301 4BQS ADP 0.0001832 0.50223 9.09091
302 4BQS K2Q 0.00503 0.41743 9.09091
303 3W5J GDP 0.00000003141 0.72503 9.31373
304 4LPS GDP 0.0000001455 0.64417 9.50413
305 1R4A GNP 0.00000000003187 0.74258 9.69697
306 1GWN GTP 0.0000000001228 0.69273 9.7561
307 5KSP GDP 0.0000001873 0.63894 10
308 3IIJ ADP 0.0001261 0.41543 10
309 3RLF ANP 0.001466 0.42402 10.1351
310 2WZF BGC 0.01506 0.41822 10.2845
311 2ZTS ADP 0.002149 0.42795 10.3586
312 3A1S GDP 0.0000005055 0.61834 10.4651
313 3N5C GDP 0.000000001326 0.75381 10.4938
314 3PCR GTP 0.0000000001019 0.71824 10.4938
315 1YTM ATP 0.0003689 0.45697 10.5033
316 4RZ3 ADP 0.0007178 0.41794 10.5085
317 3T12 GDP ALF 0.0000000001544 0.72012 10.6061
318 3T1O GDP 0.00000003566 0.55747 10.6061
319 2ODE ALF GDP 0.0000000008981 0.69448 10.6383
320 1QHH ATP 0.007865 0.41801 10.7784
321 1M7B GTP 0.0000000001437 0.73119 10.8696
322 2A5F GTP 0.00000000006762 0.72907 10.8808
323 1GOT GDP 0.000001344 0.55496 10.9589
324 1WDT GTP 0.000000000977 0.70503 11.1597
325 1GS5 NLG 0.006689 0.41089 11.2403
326 1ZUI SKM 0.0006779 0.45513 11.3095
327 2ZEJ GDP 0.000001234 0.55768 11.413
328 1XMV ADP 0.0001293 0.41882 11.5169
329 3A4M ADP 0.00007916 0.53453 11.5385
330 4J0Q GDP 0.0000000001929 0.80879 11.7783
331 1MKY GDP 0.0000000001128 0.6085 11.8451
332 1KO8 6PG 0.001728 0.40593 12
333 5KDO GDP 0.0000008231 0.57041 12.1622
334 3CNL GNP 0.0000000012 0.76894 12.2137
335 3GJ0 GDP 0.0000000003309 0.78332 12.6697
336 3ZIA ADP 0.00007738 0.44499 12.6984
337 3ZIA ATP 0.0000398 0.44053 12.6984
338 3M1I GTP 0.00000000001401 0.76427 12.7854
339 3WYF GTP 0.00000000002527 0.7568 12.7854
340 3GJX GTP 0.00000000001234 0.76658 12.963
341 1IBR GNP 0.000000000006279 0.71628 12.963
342 5BXQ GDP 0.00000000023 0.61563 12.963
343 3CH5 GDP 0.000000000468 0.60686 12.963
344 4HI0 GDP 0.000001008 0.56664 13.0653
345 2QTV GNP 0.0000000002002 0.70959 13.1737
346 3H4S ADP 0.000005558 0.41699 13.3333
347 3U6B GDP 0.00000000002458 0.85369 13.4518
348 4G5G GDP 0.0000000001161 0.80557 13.4518
349 3U6K GDP 0.0000000001665 0.79791 13.4518
350 5JBQ GDP 0.0000000000898 0.61351 13.4518
351 4P3Y GDP 0.00000000005104 0.60652 13.4518
352 4PC3 GDP 0.000000009468 0.58757 13.4518
353 2BVN GNP 0.000000000001599 0.85247 13.486
354 1D8T GDP 0.0000000001102 0.6116 13.486
355 4DCT GDP 0.0000000001771 0.78341 13.5965
356 4CVN ADP 0.0001796 0.51619 13.6126
357 4KAX GTP 0.000000000008363 0.75056 13.6646
358 5UQW GDP 0.0000000003807 0.69805 13.7566
359 4DSU GDP 0.0000000007138 0.69295 13.7566
360 2VOH CIT 0.00919 0.41439 14.0127
361 5TAR GDP 0.000000001444 0.71762 14.0541
362 5TB5 GDP 0.0000000006072 0.60938 14.0541
363 2O66 FLC 0.02551 0.40656 14.0741
364 2BCG GDP 0.000000005818 0.67118 14.0777
365 1F6B GDP 0.000000003577 0.72106 14.1414
366 2C78 GNP 0.0000000000003149 0.83292 14.321
367 2C77 GNP 0.0000000000002682 0.79529 14.321
368 4M9Q GNP 0.000000000004286 0.78538 14.5374
369 1JJ7 ADP 0.000004491 0.6221 14.6154
370 1OS1 PYR 0.001769 0.43039 14.6608
371 1OS1 ATP 0.001831 0.42828 14.6608
372 1RYH GNP 0.000000000141 0.63754 14.7783
373 3VX3 ADP 0.001491 0.43489 14.9194
374 2C5L GTP 0.000000000003006 0.72724 15.0289
375 1NRJ GTP 0.0000000001579 0.69073 15.1376
376 4K81 GTP 0.00000000003345 0.75168 15.2047
377 5XCO GDP 0.0000000008983 0.61888 15.2047
378 5O2T GSP 0.000000000008023 0.71161 15.3846
379 3WYG GTP 0.00000000001988 0.68428 15.3846
380 5E95 GDP 0.000000003766 0.68879 15.4762
381 2A9K GDP 0.000000002527 0.61422 15.508
382 2J0V GDP 0.000000007242 0.5652 15.566
383 1LFD GNP 0.000000000003049 0.7884 15.5689
384 2UZI GTP 0.000000000006051 0.77602 15.6627
385 1NVU GTP 0.00000000001689 0.76088 15.6627
386 1NVV GNP 0.00000000000319 0.72586 15.6627
387 3DDC GNP 0.000000000003868 0.72296 15.6627
388 5UFQ GNP 0.0000000002544 0.70854 15.6627
389 1CLU DBG 0.000000003366 0.69676 15.6627
390 3KUD GDP 0.000000001218 0.69147 15.6627
391 1WQ1 AF3 0.0000005087 0.66039 15.6627
392 1WQ1 GDP 0.000000008281 0.63973 15.6627
393 3QBT GNP 0.000000000001972 0.75092 15.7143
394 1WA5 GTP 0.00000000001321 0.65009 15.9091
395 1GRN GDP 0.00000000955 0.67076 16.2304
396 1GRN AF3 0.000001153 0.62916 16.2304
397 2NGR GDP 0.000000001519 0.58761 16.2304
398 4ITR GDP 0.0000001132 0.56667 16.2304
399 2NGR AF3 0.000001497 0.46174 16.2304
400 5KUT GDP 0.0000001097 0.52623 16.4021
401 1S9D GDP 0.000000006012 0.71028 16.4634
402 1RE0 GDP 0.0000000003939 0.57925 16.4634
403 1UAD GNP 0.00000000001673 0.75767 16.5714
404 1ZC3 GNP 0.00000000004918 0.74149 16.5714
405 2WMO GTP 0.0000000001169 0.77939 16.8421
406 1UPT GTP 0.00000000001338 0.74199 16.9591
407 1U8Z GDP 0.0000000009301 0.67876 17.2619
408 5EE5 GTP 0.00000000000343 0.7658 17.5439
409 3DOE GTP 0.000000000007103 0.76577 17.5758
410 1Z08 GNP 0.000000006948 0.64287 17.6471
411 4YC7 GNP 0.0000000002686 0.68982 17.6796
412 4KVG GTP 0.000000000007573 0.77197 17.8571
413 1Z2A GDP 0.00000008843 0.59746 17.8571
414 1M2O GNP 0.0000000001366 0.71977 17.8947
415 1WF3 GNP 0.0000000001802 0.71792 17.9402
416 1B7T ADP 0.00004801 0.51744 17.9487
417 3X1Z GNP 0.000000000007218 0.77964 17.9641
418 4HDQ GNP 0.00000000001669 0.76109 17.9641
419 4HDO GNP 0.000000000003904 0.72276 17.9641
420 1GUA GNP 0.000000000004497 0.72071 17.9641
421 1KK8 BEF ADP 0.00001603 0.52684 18.1818
422 5SZH GNP 0.000000000007002 0.77686 18.2266
423 5HCN GCP 0.000000004344 0.71703 18.3908
424 5GJC ATP 0.00002625 0.43536 18.552
425 5WDR GNP 0.00000000001065 0.76925 18.7134
426 3PQC GDP 0.00000003765 0.66236 18.9744
427 2WHX ADP 0.00001022 0.5876 19.256
428 2JLR ANP 0.00007943 0.44279 19.5122
429 1X1R GDP 0.000000002055 0.62257 19.6629
430 1J2J GTP 0.00000000002578 0.74277 20
431 3KTA AP5 0.001016 0.45088 20.3297
432 1CS4 GSP 0.0000000003392 0.64256 20.4444
433 3EC1 GDP 0.00000001163 0.56224 20.5962
434 2GCO GNP 0.0000000001517 0.66314 20.8955
435 2GCN GDP 0.000000006577 0.63383 20.8955
436 1S8F GDP 0.0000000007081 0.62906 20.904
437 3ZS9 ADP ALF 0.00008395 0.45339 21.0526
438 1R2Q GNP 0.000000000008229 0.62212 21.1765
439 2WIC GNP 0.000000005047 0.71391 21.3483
440 1KAO GDP 0.000000009442 0.59346 21.5569
441 1CR1 TTP 0.00246 0.405 21.6216
442 1I4D GDP 0.000000008547 0.72615 21.875
443 1E96 GTP 0.0000000001283 0.68296 21.875
444 2EFE GNH 0.000000005261 0.69202 22.0994
445 4R98 GNH 0.0000003967 0.50899 22.5092
446 4D0N GDP 0.000000005433 0.55712 22.7027
447 1OW3 GDP 0.000000007955 0.59844 22.7979
448 1MH1 GNP 0.0000000001449 0.72189 23.1183
449 1G4U GDP 0.0000001301 0.61222 23.3696
450 1G4U AF3 0.0001474 0.52347 23.3696
451 2HT6 GDP 0.00000000003041 0.60671 23.5632
452 3LXR GDP 0.00000002564 0.67015 23.7838
453 2A5J GDP 0.0000000002982 0.76041 24.0838
454 2FJU GSP 0.00000000002778 0.71722 24.1573
455 1HE1 GDP 0.00000006543 0.61745 24.4318
456 1HE1 AF3 0.00003428 0.55326 24.4318
457 1CXZ GSP 0.00000000001983 0.73537 24.7253
458 5IRC GDP 0.00000001763 0.565 24.7312
459 5HPY GDP 0.000000008659 0.59728 24.8649
460 3WY9 GDP 0.00000000004366 0.84117 25
461 1KMQ GNP 0.00000000003715 0.73624 25
462 2OM2 GDP 0.0000007046 0.5733 25
463 1HTW ADP 0.00007449 0.42965 25.3165
464 2EW1 GNP 0.0000000000007324 0.80633 25.3731
465 4XOI GTP 0.00000000006209 0.73061 25.5556
466 4XSH GSP 0.0000000004455 0.65907 25.6983
467 5DI3 GNP 0.00000000004316 0.74333 25.9459
468 1TX4 ALF GDP 0.00000000009821 0.71889 25.9887
469 3WXM GTP 0.000000000000217 0.83609 26.3982
470 1Z0A GDP 0.0000000003817 0.61655 26.4368
471 3T5G GDP 0.0000000005043 0.61417 26.5193
472 3VMF GTP 0.0000000000002517 0.83342 26.8182
473 2BME GNP 0.0000000000007423 0.81389 26.8817
474 1XTQ GDP 0.0000000002254 0.70406 27.1186
475 1NF3 GNP 0.0000000002634 0.67119 27.1795
476 1A4R GNH 0.000000001768 0.70345 27.2251
477 1A4R GDP 0.000000001453 0.69749 27.2251
478 3SBD GNP 0.00000000006309 0.69423 27.8075
479 1TU3 GNP 0.0000000000058 0.77679 27.8481
480 2W2X GSP 0.00000000001811 0.72347 28.1081
481 4NON GDP 0.00000009747 0.55282 28.8462
482 1D5C GDP 0.000000001866 0.7024 29.0123
483 1KY3 GDP 0.000000001819 0.60848 30.2198
484 1FQJ ALF 0.0000001287 0.68778 30.9524
485 1FQJ GDP 0.0000001109 0.59342 30.9524
486 4DID GDP 0.00000001468 0.69177 31.0881
487 1EK0 GNP 0.000000000004473 0.73702 31.7647
488 1Z0K GTP 0.000000000001291 0.79621 32.5581
489 2WJG GDP 0.000000009208 0.71262 32.9787
490 1VG8 GNP 0.000000000002865 0.79307 33.8164
491 1VG0 GDP 0.000000002065 0.60569 33.8164
492 2WJH GDP 0.00000001239 0.56743 36.1446
493 2WJH FLC 0.0000009559 0.50607 36.1446
494 1Z0J GTP 0.000000000004435 0.72161 36.4706
495 1YVD GNP 0.000000000004219 0.73886 37.2781
496 1VG1 GDP 0.0000000001911 0.61161 37.8378
497 1VG9 GDP 0.0000000004464 0.60277 37.8378
Pocket No.: 2; Query (leader) PDB : 4NCN; Ligand: GTP; Similar sites found: 7
This union binding pocket(no: 2) in the query (biounit: 4ncn.bio1) has 24 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3ZH4 FLC 0.02141 0.41502 2.86396
2 4RLQ 3SK 0.01697 0.41422 3.28228
3 3LN9 FLC 0.009378 0.41613 3.59712
4 1BGV GLU 0.02957 0.40282 4.23163
5 1TE2 PGA 0.0296 0.40307 4.42478
6 3MWL 8OX 0.0284 0.40257 8.69565
7 1T3D CYS 0.0228 0.40382 9.68858
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