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Receptor
PDB id Resolution Class Description Source Keywords
4O0Y 2.2 Å EC: 2.7.11.1 BACK POCKET FLEXIBILITY PROVIDES GROUP-II PAK SELECTIVITY FO KINASE INHIBITORS HOMO SAPIENS PAK4 TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: BACK POCKET FLEXIBILITY PROVIDES GROUP II P21-ACTIV KINASE (PAK) SELECTIVITY FOR TYPE I 1/2 KINASE INHI J.MED.CHEM. V. 57 1033 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
2OO A:601;
Valid;
none;
Ki = 0.06 uM
337.379 C17 H19 N7 O CCNc1...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5XVG 2.1 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INHIBITOR CZH226 HOMO SAPIENS ATP BINDING POCKET TRANSFERASE
Ref.: STRUCTURE-BASED DESIGN OF 6-CHLORO-4-AMINOQUINAZOLINE-2-CARBOXAMIDE DERIVATIV POTENT AND SELECTIVE P21-ACTIVATED KINASE 4 (PAK4) INHIBITORS. J. MED. CHEM. V. 61 265 2018
Members (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 5VEF - M77 C14 H17 N3 O2 S c1cc2cnccc....
2 4APP Ki = 0.064 uM N53 C33 H36 N6 O3 CC1(c2c(c(....
3 5VEE ic50 = 779 nM 981 C25 H23 Cl2 F N6 O CCN1c2c(cn....
4 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
5 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
6 4FII - ARG PRO LYS PRO LEU VAL ASP PRO n/a n/a
7 4NJD ic50 = 0.79 uM NJD C21 H20 N8 O COc1nc(nc(....
8 4JDK - ARG ARG ARG ARG SER TRP TYR n/a n/a
9 5XVG Ki = 0.009 uM 8FX C20 H22 Cl N7 O C[C@@H]1CN....
10 5VED - STU C28 H26 N4 O3 C[C@@]12[C....
11 2X4Z Ki = 18.7 nM X4Z C25 H28 N8 O S Cc1nc2ccsc....
12 5XVA Ki = 0.051 uM 8FU C18 H20 Cl N7 O Cc1cc(n[nH....
13 2CDZ - 23D C19 H24 Cl N7 CCn1cnc2c1....
14 4JDI - ARG ARG ARG ARG SER TRP TYR n/a n/a
70% Homology Family (32)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 5VEF - M77 C14 H17 N3 O2 S c1cc2cnccc....
2 4APP Ki = 0.064 uM N53 C33 H36 N6 O3 CC1(c2c(c(....
3 5VEE ic50 = 779 nM 981 C25 H23 Cl2 F N6 O CCN1c2c(cn....
4 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
5 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
6 4FII - ARG PRO LYS PRO LEU VAL ASP PRO n/a n/a
7 4NJD ic50 = 0.79 uM NJD C21 H20 N8 O COc1nc(nc(....
8 4JDK - ARG ARG ARG ARG SER TRP TYR n/a n/a
9 5XVG Ki = 0.009 uM 8FX C20 H22 Cl N7 O C[C@@H]1CN....
10 5VED - STU C28 H26 N4 O3 C[C@@]12[C....
11 2X4Z Ki = 18.7 nM X4Z C25 H28 N8 O S Cc1nc2ccsc....
12 5XVA Ki = 0.051 uM 8FU C18 H20 Cl N7 O Cc1cc(n[nH....
13 2CDZ - 23D C19 H24 Cl N7 CCn1cnc2c1....
14 4JDI - ARG ARG ARG ARG SER TRP TYR n/a n/a
15 4KS7 - X4Z C25 H28 N8 O S Cc1nc2ccsc....
16 4KS8 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
17 2F57 - 23D C19 H24 Cl N7 CCn1cnc2c1....
18 3FY0 ic50 = 1090 nM DW1 C23 H13 N3 O4 Ru C1=CC(C=C1....
19 6B16 Ki = 32 nM C7Y C19 H20 N8 C[C@@H](c1....
20 5DFP Ki = 22 nM 59U C28 H32 Cl N7 O CCN1c2c(cn....
21 3FXZ ic50 = 130 nM FLL C30 H18 Cl F N5 O4 Ru c1ccc(cc1)....
22 5IME Ki = 4.6 nM 6BZ C22 H22 Cl N7 O2 CC1=NC=CN(....
23 4ZY6 Ki = 5 nM 4T6 C18 H17 Cl N8 c1cc2c(c(c....
24 3Q53 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
25 4EQC ic50 = 0.008 uM XR1 C29 H28 Cl N7 O S CCN1c2c(cn....
26 4ZJJ Kd = 9.9 nM 4OR C24 H29 Cl F N5 O CCN1c2ccc(....
27 5KBR ic50 = 260 nM IPW C22 H20 Cl N5 O c1cc(ccc1C....
28 4ZLO ic50 = 54 uM 4PV C18 H18 F2 N4 CN1CCN(CC1....
29 4ZJI Kd = 340 nM 4OQ C20 H22 Cl F N4 CCN1c2ccc(....
30 5DEY Ki = 3.7 nM 59T C25 H25 Cl N6 O3 Cc1cccc(n1....
31 3Q4Z - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
32 4ZY5 Ki = 26 nM 4T5 C17 H25 N7 c1cnc(nc1N....
50% Homology Family (199)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 5OPU ic50 = 0.1237 uM A3K C15 H12 N4 Cc1cccc(c1....
3 5OP4 ic50 = 0.4476 uM A0T C19 H21 F4 N5 O3 CCNc1c(cnc....
4 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
5 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
6 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
7 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
8 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
9 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
10 5OQ6 ic50 = 0.0828 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
11 6FCF ic50 = 0.006 uM D58 C20 H22 N4 O S C[C@@H]1[C....
12 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
13 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
14 5OPB ic50 = 0.0577 uM A1N C21 H25 N5 O2 C[C@@H]1CN....
15 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
16 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
17 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
18 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
19 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
20 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
21 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
22 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
23 5OPV ic50 = 0.1203 uM A3H C19 H16 N6 Cc1cccc(c1....
24 5OOT ic50 = 0.0681 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
25 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
26 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
27 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
28 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
29 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
30 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
31 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
32 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
33 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
34 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
35 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
36 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
37 5JQ5 Kd = 2341 nM I74 C22 H30 N6 O CC(C)c1cnn....
38 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
39 1V1K Ki = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)C[C@H....
40 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
41 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
42 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
43 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
44 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
45 2UZO ic50 = 18 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
46 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
47 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
48 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
49 5JQ8 - I73 C22 H30 N6 O CC(C)c1cnn....
50 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
51 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
52 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
53 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
54 1PXP Ki ~ 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
55 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]/N=C/1N....
56 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
57 5K4J - 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
58 3PJ8 - 404 C19 H26 N6 O CC[C@H](CO....
59 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
60 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
61 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
62 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
63 5IEX - 6AF C17 H21 Br N4 O3 S C[C@H]([C@....
64 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
65 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
66 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
67 5LI9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
68 3A8W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
69 2F2U - M77 C14 H17 N3 O2 S c1cc2cnccc....
70 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
71 5OYF - B4Q C25 H27 N3 CCc1ccccc1....
72 5H8G ic50 < 0.003 uM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
73 5OS7 - A8Q C16 H19 Cl N CC(C)c1ccc....
74 5OTZ Kd = 6.5 uM AUT C15 H15 Cl2 N CCc1ccccc1....
75 5OUM - AVK C18 H18 Cl N3 c1ccc(cc1)....
76 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
77 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
78 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
79 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
80 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
81 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
82 1SZM ic50 = 6.35 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
83 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
84 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
85 1MQ4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
86 5EW9 Ki < 0.01 nM 5VC C22 H21 Cl F N3 O3 S c1cc(nc(c1....
87 5ORY ic50 = 407 uM AY4 C9 H6 F2 N2 O c1c[nH]nc1....
88 4CEG - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
89 5ORV Kd = 1297 uM A65 C6 H9 N O S3 CSc1c(c(sn....
90 5OS6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3DJ6 - AK6 C25 H24 N4 O3 S COc1ccc(cc....
92 5OSF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
93 2WQE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
94 6CPF - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
95 3FDN ic50 = 0.033 uM MMH C21 H22 N6 O3 Cc1c(c([nH....
96 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
97 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
98 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
99 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
100 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
101 1P4F - DRG C12 H11 N3 c1ccc-2c(c....
102 4TXC Kd = 0.24 uM 38G C24 H27 N5 O3 CN(C)CCN[C....
103 2YAK ic50 = 2 nM OSV C27 H31 F N4 O3 Ru S4 CC(C)Oc1cc....
104 5AUY ic50 = 1.6 uM MRI C15 H10 O7 c1cc(c(cc1....
105 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
106 5LVO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
107 4XX9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
108 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
109 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 C[C@@H]1C[....
110 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
111 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
112 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
113 5ACK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
114 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
115 5LVM - ADE C5 H5 N5 c1[nH]c2c(....
116 5MRD ic50 = 36.4 uM S26 C18 H13 Cl N2 O4 S2 CCOC(=O)C1....
117 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
118 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 C[N@@]1CCC....
119 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
120 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
121 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
122 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
123 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
124 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
125 3QD3 ic50 = 0.00000001 M 3Q5 C22 H30 N8 O2 C[C@H]1CC[....
126 1OKY ic50 = 6.5 nM STU C28 H26 N4 O3 C[C@@]12[C....
127 3IOP ic50 = 17 nM 8I1 C28 H27 N5 O3 COc1cc2c3c....
128 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
129 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
130 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
131 3QCQ ic50 = 0.00000001 M 3Q0 C13 H15 N7 CCNc1cc(nc....
132 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
133 2R5T - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
134 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
135 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
136 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
137 2UW9 - GVP C20 H20 Cl N3 c1cc(ccc1c....
138 2JDR ic50 = 0.5 nM L20 C24 H23 N5 O Cc1c2cc(cc....
139 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
140 4QMX ic50 = 11 uM H8H C27 H32 Cl N5 O5 CN1CCN(CC1....
141 4QMT ic50 = 0.01 uM H1N C29 H32 N4 O3 S CCS(=O)(=O....
142 4QMM ic50 = 0.46 uM 35R C19 H23 N7 O2 c1cc2c(cc1....
143 4QMU ic50 = 1.3 uM SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
144 4W8E - 3JB C20 H17 N7 O2 Cc1nc(no1)....
145 4QMZ ic50 = 0.21 uM B49 C22 H27 F N4 O2 CCN(CC)CCN....
146 3UBD Kd = 2.9 uM SL0 C25 H24 O12 CC1C(C(C(C....
147 4GUE Kd = 5.8 uM QCT C21 H20 O11 C[C@H]1[C@....
148 3G51 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
149 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
150 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
151 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
152 1U5R - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
153 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 [H]/N=C(N)....
154 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
155 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 [H]/N=C(N/....
156 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
157 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O C/C(=NNC1=....
158 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
159 4BDB ic50 = 85.6 uM ODO C8 H9 N O3 C/C(=NO)/c....
160 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCC/C(=NNC....
161 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]/N=C(N)....
162 6CCY ic50 = 0.003 uM EX4 C29 H33 F4 N7 O C[C@@H]1CC....
163 3QKK - SMH C28 H38 N2 O7 S CCOCCN(C[C....
164 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 C[C@@H]1C[....
165 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
166 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1[....
167 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
168 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
169 3QKL - SMR C29 H40 N4 O5 S CCOCC[N@@]....
170 5DH3 ic50 = 38.1 nM 5BS C17 H16 N6 O3 S2 CN1c2ccsc2....
171 5OTF - AQ5 C20 H24 N6 c1cnc2c(c1....
172 3TKU ic50 = 1.92 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
173 3V8S ic50 = 0.65 uM 0HD C16 H16 N4 O c1ccc(cc1)....
174 4OTH ic50 = 9 nM DRN C25 H23 N5 O2 S [H]/N=C(/N....
175 5OOI - 9YE C23 H25 N O3 CC(C)n1c2c....
176 6CQF ic50 = 0.0045 uM F97 C21 H26 F2 N8 CC(C)n1c2c....
177 3A62 - STU C28 H26 N4 O3 C[C@@]12[C....
178 3WF9 ic50 = 567 nM FS7 C24 H25 N3 O5 S C[C@H]1CCc....
179 3WF8 ic50 = 232 nM F76 C23 H23 N3 O5 S c1ccc2c(c1....
180 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
181 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
182 3WF5 ic50 = 81 nM FZ8 C17 H17 N7 c1ccc2c(c1....
183 3FY0 ic50 = 1090 nM DW1 C23 H13 N3 O4 Ru C1=CC(C=C1....
184 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
185 4OBQ ic50 = 0.065 uM 2QT C20 H20 F N5 O c1cc2c(cc1....
186 4U43 Kd = 48 uM 3D8 C11 H9 N5 c1cc(cnc1)....
187 4OBP ic50 = 0.017 uM 2QU C12 H8 F N5 c1cc(nc2c1....
188 6C0T ic50 = 43 nM EE4 C30 H30 F N5 O5 CCCOc1ccc(....
189 6BXI - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
190 3DV3 - MEK C18 H18 F3 I N2 O5 c1cc(c(cc1....
191 3EQD - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
192 5F9E ic50 = 0.46 nM 5VS C23 H21 N5 O2 CC1(NC(=O)....
193 1XJD Ki = 0.33 nM STU C28 H26 N4 O3 C[C@@]12[C....
194 5DBX - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
195 3TXO ic50 = 9 nM 07U C17 H19 N5 CC(C)(CNc1....
196 4USF - 6UI C19 H15 N3 O COc1ccc2cc....
197 2J51 - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
198 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
199 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 2OO; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 2OO 1 1
2 2OQ 0.43617 0.742424
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5XVG; Ligand: 8FX; Similar sites found with APoc: 743
This union binding pocket(no: 1) in the query (biounit: 5xvg.bio1) has 38 residues
No: Leader PDB Ligand Sequence Similarity
1 1FUT 2GP None
2 5KK4 44E None
3 3LF0 ATP None
4 1C1L GAL BGC None
5 2E1A MSE None
6 5VX5 FUC GAL NAG GAL BGC None
7 4CQK PIO None
8 1Q3P GLU ALA GLN THR ARG LEU None
9 1Y52 BTN None
10 5FUI APY None
11 2HO2 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU None
12 2GCG DGY 1.02389
13 3JQ7 DX2 1.04167
14 1I7M CG 1.1236
15 2HZQ STR 1.14943
16 1SDW IYT 1.36519
17 1OFL NGK GCD 1.36519
18 3NKS ACJ 1.36519
19 5NLD LBT 1.43885
20 1SBR VIB 1.5
21 2XOC ADP 1.53257
22 3WG3 A2G GAL NAG FUC 1.68539
23 2FB3 MET 1.70648
24 4MOB ADP 1.70648
25 3HYW DCQ 1.70648
26 2Q7D ANP 1.70648
27 3B1Q NOS 1.70648
28 5JWC 4W0 1.70648
29 1GPM AMP 1.70648
30 3EFS BTN 1.71674
31 3UW5 MAA CHG PRO 0DQ 1.72414
32 2D6M LBT 1.88679
33 2Q8E OGA 2.04778
34 2OS2 OGA 2.04778
35 2YBP 2HG 2.04778
36 2P5B OGA 2.04778
37 5W75 SUC 2.04778
38 1OIJ AKG 2.04778
39 4CC6 L5Y 2.04778
40 2OJW ADP 2.04778
41 1AUA BOG 2.04778
42 4OCJ NDG 2.04778
43 2NZ5 226 2.04778
44 3KV5 OGA 2.04778
45 6GVZ CHO 2.04778
46 3WXL ADP 2.04778
47 2GWH PCI 2.04778
48 5LY2 OGA 2.04778
49 5O9W AKG 2.04778
50 3T1A 5MA 2.04778
51 1OIK AKG 2.04778
52 1R37 ETX 2.04778
53 2WME NAP 2.04778
54 2RCA GLY 2.05479
55 4F8L AES 2.06897
56 4OFG PCG 2.08333
57 4CS9 AMP 2.1164
58 2DC1 CIT 2.11864
59 5TZO 7V7 2.12766
60 5CGE 51F 2.16606
61 4C5N ACP 2.17391
62 4UTW RFW 2.18341
63 1A5Z FBP 2.19436
64 3T4L ZEA 2.22222
65 1BC5 ACE ASN TRP GLU THR PHE 2.23048
66 3EXS 5RP 2.26244
67 4HIA FMN 2.27273
68 5HV0 AKG 2.30415
69 5GZ9 ANP 2.38908
70 3X01 AMP 2.38908
71 1F9V ADP 2.38908
72 2BMB PMM 2.38908
73 3DNT ATP 2.38908
74 2I6A 5I5 2.38908
75 4YRI 4JH 2.38908
76 1IT7 GUN 2.38908
77 3A23 GAL 2.38908
78 4UCF GLA 2.38908
79 4K37 SAM 2.38908
80 1TD2 PXL 2.43902
81 3MBI HSX 2.43902
82 5NC1 NAG 2.53165
83 3TW1 AHN 2.53165
84 1TZD ADP 2.54545
85 4CSD MFU 2.57353
86 1V3S ATP 2.58621
87 4USI AKG 2.5974
88 4LED XXR 2.61194
89 1LK7 DER 2.62009
90 3KYG 5GP 5GP 2.64317
91 1WLJ U5P 2.6455
92 3ORQ ADP 2.65252
93 5TQZ GLC 2.66667
94 4RT1 C2E 2.67857
95 6CZI 38E 2.67857
96 3KCC CMP 2.69231
97 1GSA ADP 2.73038
98 5VZ0 ADP 2.73038
99 2Z3U CRR 2.73038
100 2VQD AP2 2.73038
101 2WKQ FMN 2.73038
102 3ETH ATP 2.73038
103 4OB6 S2T 2.73038
104 4OJ8 AKG 2.73038
105 1YP4 ADP 2.73038
106 3K5I ADP 2.73038
107 5ENZ UDP 2.73038
108 1X8X TYR 2.73038
109 4I9B NAD 2.73038
110 5XLS URA 2.73038
111 4C2C ALA ALA ALA 2.73038
112 3ROE THM 2.73038
113 1IZC PYR 2.73038
114 5F1V 3VN 2.73038
115 1MJT ITU 2.73038
116 1XF1 CIT 2.73038
117 2R3A SAM 2.73038
118 6F3M ADN 2.73038
119 3WWX DIA 2.73038
120 4FE2 ADP 2.7451
121 4FE2 AIR 2.7451
122 3VKC FPQ 2.7972
123 1QKQ MAN 2.8169
124 3WUC GLC GAL 2.91971
125 3NOJ PYR 2.94118
126 6GNO XDI 2.96296
127 3P2H NOO 2.98507
128 2QV6 GTP 2.98507
129 4WJT NAG 2.99401
130 5OES ADP 3.07167
131 3I0O ADP 3.07167
132 1I7L ATP 3.07167
133 4RD0 GDP 3.07167
134 5COU ATP 3.07167
135 6BMN PAP 3.07167
136 3TDV GDP 3.07167
137 2PUL ACP 3.07167
138 4U98 ACP 3.0837
139 2CDO GAL AAL GAL AAL GAL AAL 3.125
140 3H4V DVP 3.125
141 1HDC CBO 3.14961
142 3OJI PYV 3.1746
143 1O68 KIV 3.27273
144 3T2W BTN 3.27869
145 1NXJ TLA 3.27869
146 4CUB GAL NAG 3.27869
147 5K2M ADP 3.2967
148 6F7X MFU 3.33333
149 5WHU SIA GAL 3.3557
150 2J9D ADP 3.36134
151 3PN1 IVH 3.41297
152 5VLQ ANP 3.41297
153 4WOE ADP 3.41297
154 3W5N RAM 3.41297
155 3JU6 ANP 3.41297
156 2YRX AMP 3.41297
157 1GQG DCD 3.41297
158 5H9Y BGC BGC BGC BGC BGC 3.41297
159 1OBD ATP 3.41297
160 1C1X HFA 3.41297
161 3JQQ A2P 3.41297
162 1I1E DM2 3.41297
163 2HGS ADP 3.41297
164 3JQ3 ADP 3.41297
165 4FMS BDP 3.41297
166 5E62 Z3Q GAL 5N6 3.41297
167 5U7W ADE 3.41297
168 5E65 5N6 GAL 3.41297
169 5WS9 OXL 3.41297
170 5WL1 D3D 3.41297
171 5WL1 CUY 3.41297
172 1BXG HCI 3.41297
173 5O0J 8BR 3.41297
174 1BW9 PPY 3.41297
175 3THR C2F 3.41297
176 2IRY DGT 3.41297
177 1BW9 NAD 3.41297
178 1C1D PHE 3.41297
179 1F52 ADP 3.41297
180 1O9P MLA 3.41297
181 5KWW 6YA 3.41297
182 2V0U FMN 3.42466
183 2FUE M1P 3.43511
184 5DKK FMN 3.44828
185 1VL1 CIT 3.44828
186 3ZJX BOG 3.46021
187 5XEG AKG 3.4632
188 4I9A NCN 3.47222
189 4GGZ BTN 3.47826
190 3P7N FMN 3.48837
191 4JMO JAF 3.5
192 3CBC DBS 3.53535
193 4R38 RBF 3.57143
194 5H20 GLC 3.6036
195 4B1L FRU 3.63636
196 1S9D AFB 3.65854
197 4IAW LIZ 3.7234
198 5VX9 FUC GAL NAG GAL BGC 3.72671
199 1P6O HPY 3.72671
200 1DTL BEP 3.72671
201 5DZT AMP 3.75427
202 5L2R MLA 3.75427
203 4XJ6 GH3 3.75427
204 2IO8 ADP 3.75427
205 4GCZ FMN 3.75427
206 1OFZ FUC 3.75427
207 3RS8 ALA TRP LEU PHE GLU ALA 3.75427
208 4NOS ITU 3.75427
209 2ORO 228 3.75427
210 4D1J DGJ 3.75427
211 1OFZ FUL 3.75427
212 5NM7 GLY 3.7594
213 5FS0 5JC 3.79147
214 2GQS ADP 3.79747
215 2GQR ADP 3.79747
216 2GQS C2R 3.79747
217 4RYV ZEA 3.87097
218 1B09 PC 3.8835
219 4D06 NAR 3.88693
220 5JLB SAH 3.94265
221 5ME4 HP4 4.0146
222 4K55 H6P 4.03226
223 6F9G PUT 4.04984
224 5MW8 ATP 4.09556
225 5KJW 53C 4.09556
226 5EQY 5RA 4.09556
227 3N9P OGA 4.09556
228 2IVD ACJ 4.09556
229 4FE9 GLC GLC BGC GLC GLC GLC GLC 4.09556
230 4E8C GAL 4.09556
231 5JBE MAL 4.09556
232 5XQL C2E 4.12371
233 5DJT FMN 4.13793
234 5EFW FMN 4.13793
235 1RGE 2GP 4.16667
236 5J75 6GQ 4.16667
237 3KMT SAH 4.20168
238 1QK3 5GP 4.29185
239 4MTI 2DX 4.34783
240 4CNO 9PY 4.36508
241 2PFC PLM 4.37158
242 3SAO DBH 4.375
243 1F5F DHT 4.39024
244 4LI4 AMP 4.41176
245 1PVC ILE SER GLU VAL 4.41176
246 5OLK DTP 4.43686
247 4UWH JXM 4.43686
248 4ZS4 ATP 4.43686
249 4Y4V DAL 4.43686
250 1CKM GTP 4.43686
251 6C1S EFV 4.43686
252 6EZ6 C5Z 4.43686
253 1CKN GTP 4.43686
254 1LSH PLD 4.43686
255 3W0O ADP 4.43686
256 3W0O HY0 4.43686
257 5X7Q GLC GLC GLC GLC 4.43686
258 5X7Q GLC GLC GLC GLC GLC 4.43686
259 5AE9 OKO 4.43686
260 4D52 GIV 4.43686
261 4CTA ATP 4.43686
262 1HXD BTN 4.43686
263 4BG4 ADP 4.43686
264 1FP1 HCC 4.43686
265 2BS5 BGC GAL FUC 4.44444
266 1FWV SGA MAG FUC 4.47761
267 5H9Q TD2 4.51613
268 2Y91 98J 4.5283
269 1MDC PLM 4.54545
270 1N9L FMN 4.58716
271 4JGP PYR 4.60829
272 3CM2 X23 4.61538
273 3W9F I3P 4.61538
274 3ZZS TRP 4.61538
275 2XG5 EC5 4.62428
276 2XG5 EC2 4.62428
277 3VPD ANP 4.62633
278 2PEL LBT 4.66102
279 3OQJ 3CX 4.66926
280 2YKL NLD 4.71698
281 3PDT ADP 4.72727
282 2ZHL NAG GAL GAL NAG 4.72973
283 1BHX ASP PHE GLU GLU ILE 4.7619
284 1AUX AGS 4.77816
285 1PK8 ATP 4.77816
286 3V4S ATP 4.77816
287 2ZL7 FUC GAL NGA 4.77816
288 5FI4 5XV 4.77816
289 1U6R IOM 4.77816
290 4B0T ADP 4.77816
291 5DXT 5H5 4.77816
292 3S6X SIA GAL BGC 4.77816
293 3B6R ADP 4.77816
294 3B6R CRN 4.77816
295 3A16 PXO 4.77816
296 1U6R ADP 4.77816
297 1X54 4AD 4.77816
298 2RDE C2E 4.78088
299 3IWD M2T 4.83871
300 2AQX ATP 4.84429
301 4XMF HSM 4.8913
302 5DJU FMN 4.91803
303 3KFF ZBT 4.93827
304 3KFF XBT 4.93827
305 6GG9 FMN 4.93827
306 3I9U DTU 4.94297
307 2W58 ADP 4.9505
308 3VPC ADP 4.96454
309 1CBK ROI 5
310 2QX0 PH2 5.03145
311 1GT4 UNA 5.03145
312 2QHS OCA 5.06329
313 1KDK DHT 5.08475
314 1ZEA DVA DPR GLY DSN DGN DHI DTY DAS DSN 5.09259
315 4R78 AMP 5.11945
316 3HAV ATP 5.11945
317 4FFG LBS 5.11945
318 2QK4 ATP 5.11945
319 4PZ6 GMP 5.11945
320 5C1P ADP 5.11945
321 4FFG 0U8 5.11945
322 2V58 LZJ 5.11945
323 2YW2 ATP 5.11945
324 4GNC ASO 5.11945
325 4MXP DB4 5.11945
326 3REU ATP 5.11945
327 3DGY 2GP 5.15464
328 4M7T SAM 5.18518
329 5DYO FLU 5.18868
330 5XQW 8EU 5.21327
331 5TBM 79A 5.21739
332 1OPB RET 5.22388
333 3ZXE PGZ 5.26316
334 4NVP 7CH 5.26316
335 1W2D ADP 5.28302
336 5OCG 9R5 5.29101
337 2II3 CAO 5.34351
338 4OCT AKG 5.40541
339 1QAW TRP 5.40541
340 2XMI FLC 5.42986
341 4RF7 ARG 5.46075
342 4DFU QUE 5.46075
343 4L77 CNL 5.46075
344 1ELI PYC 5.46075
345 1EHI ADP 5.46075
346 3GL0 HXX 5.46075
347 4TXE 38F 5.46075
348 2P3V SRT 5.46875
349 3E81 SLB 5.4878
350 5V3D FCN 5.51724
351 1FAO 4IP 5.55556
352 1S68 AMP 5.62249
353 5H9P TD2 5.6962
354 3NV3 GAL NAG MAN 5.7971
355 3WVR AMP 5.80205
356 1NJJ GET 5.80205
357 3ACL 3F1 5.80205
358 3TY5 ADP 5.80205
359 4M51 BEZ 5.80205
360 5C4L 4XR 5.80205
361 5C4L SIS 5.80205
362 6CGD GNP 5.80205
363 6CGD AKN 5.80205
364 3TY5 ATP 5.80205
365 6EOM ALA LYS 5.80205
366 6EWZ APC 5.90717
367 1U4J MAN 5.9322
368 5E6O TRP GLU GLU LEU 5.9322
369 5TVF CGQ 5.96491
370 3RGA LSB 6.00707
371 6HDT BTN 6.01504
372 5HV7 RBL 6.14334
373 5Y4R C2E 6.14334
374 2OG7 SIN 6.14334
375 3DRW AMP 6.14334
376 6F5W KG1 6.14334
377 2AWN ADP 6.14334
378 4KVL PLM 6.14334
379 6GBV FMN 6.16438
380 1Y7P RIP 6.27803
381 2ZMF CMP 6.34921
382 4BJ8 BTN 6.34921
383 5XLY C2E 6.40569
384 2BKK ADP 6.43939
385 3TM0 ANP 6.46388
386 3TM0 B31 6.46388
387 5JSP DQY 6.46766
388 6GW4 CHO 6.48464
389 5I35 ANP 6.48464
390 1UPR 4IP 6.50407
391 5ODY 9SK 6.52174
392 3O75 F1X 6.61765
393 2QHV OC9 6.66667
394 5W10 CMP 6.66667
395 1NKI PPF 6.66667
396 2W5P CL8 6.71141
397 1NBU PH2 6.72269
398 1FQK ALF 6.80272
399 2PYW ADP 6.82594
400 4IRX INS 6.82594
401 4GYI ADP 6.82594
402 3ZW2 NAG GAL FUC 6.89655
403 5D9G GLU ASN LEU TYR PHE GLN 6.91057
404 1U29 I3P 6.97674
405 1R0X ATP 6.99301
406 3AHW 2AM 7.01754
407 3VPB ADP 7.14286
408 3QXV MTX 7.14286
409 4CYI ATP 7.16724
410 3QO8 SSA 7.16724
411 5LUN OGA 7.16724
412 1YKD CMP 7.16724
413 4OE4 NAD 7.16724
414 2GVJ DGB 7.16724
415 5SVV FMN 7.29927
416 5OVV ACE ILE GLU SER THR GLU ILE 7.31707
417 4CPB GAL CN8 7.43802
418 3H0L ADP 7.44681
419 2ET1 GLV 7.46269
420 4WUJ FMN 7.48299
421 2IF8 ADP 7.50853
422 3KAL HGS 7.50853
423 4OCV ANP 7.50853
424 2I4O ATP 7.50853
425 4PBG BGP 7.50853
426 1QB7 ADE 7.62712
427 1UYY BGC BGC 7.63359
428 5KEW 6SB 7.63889
429 4O4F ATP 7.66129
430 4O4F IHP 7.66129
431 5T7I LAT NAG GAL 7.74194
432 1ZTH ADP 7.75194
433 1ZP9 ATP 7.75194
434 2H7C SIA 7.84983
435 2HRL SIA GAL SIA BGC NGA CEQ 7.87402
436 1WAP TRP 8
437 5VM6 9EG 8.0292
438 5VKI THR NGA GAL NAG 8.125
439 2G30 ALA ALA PHE 8.13953
440 5YJS SAL 8.19113
441 2VPQ ANP 8.19113
442 4BXF AKG 8.19113
443 1SQL GUN 8.21918
444 3KYF 5GP 5GP 8.22511
445 2ISJ FMN 8.26087
446 3QRC SCR 8.28025
447 2PR5 FMN 8.33333
448 2HK9 SKM 8.36364
449 4LO6 SIA GAL 8.42105
450 3SJK LYS PRO VAL LEU ARG THR ALA 8.42105
451 4WW7 AMP 8.42912
452 3BF1 PAU 8.43373
453 4PU5 ANP 8.53242
454 5EXK 5AD 8.53242
455 5EXK MET 8.53242
456 4QDC ASD 8.53242
457 1RDS GPC 8.57143
458 1ULE GLA GAL NAG 8.66667
459 3NZ1 3NY 8.81226
460 5EJL C2E 8.87097
461 4IX4 ADP 8.87372
462 5KBF CMP 8.87372
463 1YXM ADE 8.87372
464 3CF6 SP1 8.98204
465 3TAO PGH 8.98876
466 4JLS 3ZE 9.21053
467 1M6P M6P 9.21053
468 6E2B PT7 9.21053
469 3VOT ADP 9.21502
470 1M0W ANP 9.21502
471 4OAV ACP 9.21502
472 4WCX ALA 9.21502
473 5K21 6QF 9.21986
474 2HKA C3S 9.23077
475 2BVE PH5 9.2437
476 2E27 AB0 9.2437
477 6FX2 FUC C4W NAG BMA MAN NAG GAL 9.30233
478 3T50 FMN 9.375
479 1J3R 6PG 9.47368
480 3K7S R52 9.49721
481 1DZK PRZ 9.55414
482 1T36 ADP 9.55631
483 4XYM A12 9.56522
484 3EW2 BTN 9.62963
485 4Z28 BTN 9.70149
486 5U98 1KX 9.74729
487 5KWY C3S 9.77444
488 2P7Q GG6 9.77444
489 3UDZ ADP 9.89761
490 3HQP OXL 9.89761
491 4PAB THG 9.89761
492 3TA2 AKG 10.1695
493 5F90 LMR 10.2564
494 6FA4 D1W 10.4046
495 1RL4 BRR 10.6383
496 1W8S FBP 10.6464
497 5ACM MBT 10.8108
498 5MRH Q9Z 10.9215
499 1M1B SPV 10.9215
500 3O2K DST 10.9215
501 5I0U DCY 11
502 4Y24 TD2 11.039
503 3U7S 017 11.1111
504 1JQN DCO 11.2628
505 5A0U CHT 11.2628
506 1ZEI CRS 11.3208
507 5KJZ PCG 11.3333
508 43CA NPO 11.5044
509 5ZCT ANP 11.6041
510 1N5S ADL 11.6071
511 3O7J 2AL 11.6402
512 4YLZ LAT NAG GAL 11.7647
513 6F5U CQN 11.9048
514 6G9I CXX 11.9048
515 3TII ANP 11.9454
516 5YK1 ANP 12.2867
517 5CIC 51R 12.963
518 6FL8 ADP 12.9693
519 6FL8 TIY 12.9693
520 5VNF VAL THR SER VAL VAL 12.9693
521 1VRP ADP 12.9693
522 5TDF ADP 12.9693
523 1VRP IOM 12.9693
524 1FDJ 2FP 12.9693
525 4K6B GLU 13.0435
526 1FHX 4IP 13.1783
527 5N0L ILE 13.2075
528 4YEE 4CQ 13.3333
529 2QQC AG2 13.3929
530 1N13 AG2 13.4615
531 1TQP ATP 13.4752
532 4NPL AKG 13.6
533 1IA9 ANP 13.9286
534 5F6U 5VK 14.0127
535 6E8I PTR 14.2012
536 3EUF BAU 14.3345
537 1NE7 AGP 14.5329
538 4O9S 2RY 14.8837
539 2GC0 PAN 14.8936
540 5FPX GLY SER SER HIS HIS HIS HIS HIS 15.0442
541 4MA6 28E 15.2866
542 4BKS X6C 15.3846
543 5O3Q CMP 15.8333
544 2AGC DAO 16.0494
545 1RZX ACE VAL LYS GLU SER LEU VAL 16.3265
546 4AZW ATP 16.7235
547 3KIF GDL 16.9811
548 4P25 FUC GAL NAG FUC 17.0648
549 3IWJ NAD 18.43
550 2YVJ NAI 18.7713
551 5B09 4MX 19.2308
552 4Z4P SAH 19.2771
553 4XZ3 ACP 19.5652
554 3LQV ADE 20.5128
555 3SHR CMP 21.5017
556 4O1P ANP 22.8669
557 1ONI BEZ 23.1884
558 4FL3 ANP 24.5734
559 5CKW ANP 24.9147
560 3PP0 03Q 24.9147
561 2UV4 AMP 25.6579
562 3VHE 42Q 25.9386
563 3K0T BGC 27.2727
564 2WU6 DKI 27.6451
565 6FYV 3NG 27.9863
566 5USZ SKE 28.0277
567 5QIN J2V 28.3276
568 5ML3 DL3 28.8591
569 1U59 STU 29.6167
570 2QLU ADE 30.0341
571 4XH0 ADP 30.0341
572 4KBA 1QM 30.0341
573 5OKT 9XK 30.0341
574 6ES0 BW8 30.2839
575 5HCY 60D 30.3754
576 3NW7 LGV 31.3993
577 1OPK P16 31.3993
578 1K3A ACP 31.3993
579 2CSN CKI 31.7406
580 3SRV S19 31.769
581 4WOV 3SM 32.0819
582 5C03 AGS 32.0819
583 4CLI 5P8 32.0819
584 4E93 GUI 32.0819
585 6GWR FEW 32.0819
586 4F4P 0SB 32.2344
587 4FF8 14S 32.4232
588 5U6C 7YS 32.4232
589 5NKB 8ZT 32.7645
590 3UIM ANP 32.7645
591 4EWH T77 33.0909
592 5HES 032 33.1058
593 4Y93 746 33.1058
594 4E1Z 0MX 33.677
595 2H8H H8H 33.7884
596 1Y57 MPZ 33.7884
597 3C1X CKK 33.7884
598 1BYG STU 33.813
599 3G5D 1N1 33.9161
600 4TWP AXI 33.9483
601 2Y6O 1N1 34.0206
602 5EOB 5QQ 34.1297
603 4AT3 LTI 34.1297
604 2OO8 RAJ 34.1297
605 5LPB ADP 34.471
606 4P5Z Q7M 34.471
607 5LPZ ADP 34.471
608 5ZTN CUR 34.471
609 5MJA 7O3 35.1536
610 4GJ3 0XP 35.4949
611 3LXK MI1 35.4949
612 3KRL KRL 35.4949
613 3PLS ANP 35.4949
614 5FBN 5WF 35.7934
615 5JFS 6K0 35.8362
616 3EKK GS2 36.1775
617 3BU5 ATP 36.1775
618 1IR3 ANP 36.1775
619 4BTK DTQ 36.1775
620 6C7Y ADP 36.3636
621 1O9U ADZ 36.5188
622 2XVD AS6 36.5188
623 5WO4 B7V 36.5188
624 4NM5 ADP 36.8601
625 5KO1 6UY 37.1025
626 3F7Z 34O 37.2014
627 3LXN MI1 37.2014
628 3ZRM ZRM 37.2014
629 4YZC STU 37.5427
630 2JLD AG1 37.884
631 1JPA ANP 38.5666
632 3BZ3 YAM 38.7681
633 3VRY B43 38.9078
634 5WNL STU 39.2491
635 4UXL 5P8 39.5904
636 2XN5 FUN 40
637 5TO8 7FM 40.0709
638 6GQM F8H 40.273
639 5VC5 96M 40.4844
640 6A1G 9OL 40.6143
641 3GC0 AMP 40.6143
642 5T8O 76Z 40.9556
643 4U0I 0LI 40.9556
644 4PNI KQQ 40.9556
645 4L9I 8PR 40.9556
646 3HMO STU 40.9556
647 4YMJ 4EJ 40.9556
648 5N87 N66 41.2969
649 4AG8 AXI 41.2969
650 4ASE AV9 41.2969
651 4CRL C1I 41.2969
652 2OFV 242 41.5162
653 4Q5H ANP 41.954
654 5CEO 50D 41.9795
655 5UKL SIX 41.9795
656 3PVW QRX 41.9795
657 4RFM 3P6 42.1053
658 2HK5 1BM 42.2222
659 5JKG 6LF 42.3208
660 3FC2 IBI 42.3208
661 5TA6 79D 42.3208
662 2A19 ANP 42.6056
663 3RI1 3RH 42.6621
664 4IDT T28 42.6621
665 6C0T EE4 43.0034
666 5UR1 YY9 43.0034
667 3GQI ACP 43.0034
668 2PVF ACP 43.0034
669 4CSV STI 43.2727
670 1VJY 460 43.3447
671 5MY8 RXZ 43.3447
672 4OTH DRN 43.3447
673 3O0G 3O0 43.4931
674 1UNH IXM 43.4931
675 3KMW ATP 43.5424
676 4QTB 38Z 43.686
677 2QCS ANP 43.686
678 2GU8 796 44.0273
679 3IDB ANP 44.0273
680 1XJD STU 44.0273
681 1RE8 BD2 44.0273
682 4Y85 499 44.0273
683 1ZY5 ANP 44.0273
684 4DC2 ADE 44.0273
685 4K33 ACP 44.3686
686 6FYL 3NG 44.3686
687 3FHI ANP 44.3686
688 5JGA 6KC 44.3686
689 4WNK 453 44.3686
690 4WB6 ATP 44.3686
691 4WB7 ATP 44.3686
692 5LI9 ACP 44.3686
693 2X2M X2M 44.3686
694 5LI1 ANP 44.7099
695 5EFQ ADP 44.7099
696 5AWM ANP 44.7099
697 3SXS PP2 44.7761
698 6GIN IR2 45.0512
699 6GU6 1QK 45.0512
700 5HQ0 LZ9 45.0512
701 3H9R TAK 45.0512
702 5BVE 4VG 45.3925
703 2F2U M77 45.7338
704 4H3Q ANP 45.7338
705 4H3P ANP 45.7338
706 4BCM T7Z 45.7338
707 2XMY CDK 45.7338
708 5LMK 6ZK 45.7338
709 3E7O 35F 45.7338
710 6GUE FB8 45.7338
711 4BCN T9N 45.7338
712 4BCQ TJF 45.7338
713 5X8I SQZ 46.0751
714 2BPM 529 46.0751
715 5EH0 5NW 46.124
716 4BHN BH9 46.4164
717 4NST ADP 46.4164
718 6G33 5ID 46.4164
719 3TXO 07U 46.7577
720 6E2O S0L 46.7577
721 5H2U 1N1 46.8165
722 1V0O INR 46.875
723 6CZ3 FLJ 46.9697
724 4UX9 ANP 47.099
725 1OUK 084 47.099
726 4LOO SB4 47.099
727 4CFU 2WC 47.4403
728 3GC8 B45 47.4403
729 4IZY 1J2 47.4403
730 3TTI KBI 47.4403
731 4WHZ 3NL 47.4403
732 5Y86 HRM 47.4403
733 1CM8 ANP 47.4403
734 3PTG 932 47.4403
735 3GNI ATP 47.7816
736 3ALN ANP 48.1229
737 3SLS ANP 48.1229
738 3SLS 77D 48.1229
739 4I6H 1C8 48.4642
740 3E8N ATP 49.1468
741 3E8N VRA 49.1468
742 5EKO N17 49.1468
743 2WEL K88 49.8294
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