Receptor
PDB id Resolution Class Description Source Keywords
4OZ1 1.74 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF HUMAN CAPERALPHA UHM BOUND TO SF3B155 U HOMO SAPIENS U2AF HOMOLOGY MOTIF UHM PROTEIN-PEPTIDE COMPLEX PRE-MRNA FACTOR TRANSCRIPTION
Ref.: CANCER-RELEVANT SPLICING FACTOR CAPER ALPHA ENGAGES ESSENTIAL SPLICING FACTOR SF3B155 IN A SPECIFIC TER COMPLEX. J.BIOL.CHEM. V. 289 17325 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LYS ARG LYS SER ARG TRP ASP GLU THR PRO C:335;
Valid;
none;
submit data
1246.37 n/a O=C(N...
CL A:602;
Invalid;
none;
submit data
35.453 Cl [Cl-]
LYS A:603;
Invalid;
none;
submit data
147.195 C6 H15 N2 O2 C(CC[...
K A:601;
Part of Protein;
none;
submit data
39.098 K [K+]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4OZ1 1.74 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF HUMAN CAPERALPHA UHM BOUND TO SF3B155 U HOMO SAPIENS U2AF HOMOLOGY MOTIF UHM PROTEIN-PEPTIDE COMPLEX PRE-MRNA FACTOR TRANSCRIPTION
Ref.: CANCER-RELEVANT SPLICING FACTOR CAPER ALPHA ENGAGES ESSENTIAL SPLICING FACTOR SF3B155 IN A SPECIFIC TER COMPLEX. J.BIOL.CHEM. V. 289 17325 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 552 families.
1 4OZ1 - LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 426 families.
1 4OZ1 - LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 322 families.
1 4OZ1 - LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: LYS ARG LYS SER ARG TRP ASP GLU THR PRO; Similar ligands found: 139
No: Ligand ECFP6 Tc MDL keys Tc
1 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 1 1
2 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.627119 0.90411
3 GLU GLN ASP LYS TRP ALA SER 0.578616 0.771429
4 ACE TRP ARG VAL PRO 0.574194 0.861111
5 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.573171 0.763889
6 ILE SER PRO ARG THR LEU ASP ALA TRP 0.55914 0.958904
7 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.55814 0.849315
8 GLU ALA ASP LYS TRP GLN SER 0.552795 0.771429
9 GLU ASN ASP LYS TRP ALA SER 0.552795 0.760563
10 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.550802 0.933333
11 GLU LEU ASP LYS TRP ALA SER 0.54321 0.75
12 ARG ARG ARG ARG TRP ARG GLU ARG GLN 0.538462 0.785714
13 GLU LEU ASP NRG TRP ALA SER 0.538012 0.7625
14 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.533333 0.897436
15 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.532609 0.90411
16 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.53125 0.909091
17 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.530928 0.907895
18 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.526316 0.915493
19 GLU LEU ARG SER ARG TYR TRP ALA ILE 0.52514 0.815789
20 GLU LEU GLU LYS TRP ALA SER 0.524691 0.736111
21 GLN ALA SER GLN GLU VAL LYS ASN TRP 0.523256 0.777778
22 ALA ASN SER ARG TRP GLN THR SER ILE ILE 0.522727 0.835616
23 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.519553 0.958904
24 GLU LEU ASP ORN TRP ALA SER 0.518293 0.736111
25 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.517588 0.897436
26 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.515152 0.906667
27 GLN ALA SER GLN ASP VAL LYS ASN TRP 0.514451 0.777778
28 GLU LEU ASP LYS TRP ALA ASN 0.512048 0.712329
29 ALA ASN SER ARG TRP GLN VAL THR ARG VAL 0.511905 0.861111
30 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.510417 0.92
31 SER ARG TYR TRP ALA ILE ARG THR ARG 0.50838 0.813333
32 ALA LEU ASP LYS TRP ALA SER 0.506173 0.75
33 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.50303 0.833333
34 SER ARG ASP HIS SER ARG THR PRO MET 0.502732 0.881579
35 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.502513 0.864865
36 SER PRO LEU ASP SER LEU TRP TRP ILE 0.497143 0.851351
37 GLU LEU ASP LYS TRP ALA GLY 0.49697 0.684932
38 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.494565 0.733333
39 LYS ARG TRP ILE ILE LEU GLY LEU ASN LYS 0.494565 0.797297
40 SER ARG ARG TRP ARG ARG TRP ASN ARG 0.490566 0.819444
41 ALA ASN SER ARG TRP ALY THR SER ILE ILE 0.483696 0.826667
42 ALA SER ASN GLU ASN TRP GLU THR MET 0.482143 0.710526
43 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.476744 0.756757
44 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.472081 0.810811
45 ALA TRP ARG HIS PRO GLN PHE GLY GLY 0.471795 0.861111
46 LYS ARG TRP ILE ILE MET GLY LEU ASN LYS 0.471503 0.75641
47 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.46875 0.863014
48 PRO SER ILE ASP ARG SER THR LYS PRO 0.466667 0.902778
49 ARG PHE PRO LEU THR PHE GLY TRP 0.466321 0.931507
50 ACE PRO TRP ALA THR CYS ASP SER NH2 0.466292 0.876712
51 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.465909 0.746667
52 ARG LEU TRP SER 0.465409 0.777778
53 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.465347 0.932432
54 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.464865 0.942857
55 SER TRP PHE PRO 0.4625 0.830986
56 MET HIS PRO ALA GLN THR SER GLN TRP 0.461538 0.855263
57 PRO ALA TRP ASP GLU THR ASN LEU 0.461111 0.780822
58 MET TRP ARG PRO TRP 0.460674 0.776316
59 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.458937 0.907895
60 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.458333 0.734177
61 ARG TYR PRO LEU THR PHE GLY TRP 0.457286 0.906667
62 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.456731 0.894737
63 GLU LEU ASP HOX TRP ALA SER 0.456647 0.68
64 ASN ASP TRP LEU LEU PRO SER TYR 0.455026 0.842105
65 GLU LEU ASP HIS TRP ALA SER 0.454023 0.726027
66 LEU GLU LYS ALA ARG GLY SER THR TYR 0.453552 0.77027
67 VAL ASP SER LYS ASN THR SER SER TRP 0.451429 0.777778
68 ALA LEU ASP LYS TRP ASP 0.450617 0.708333
69 ILE ASP TRP PHE GLU GLY LYS GLU 0.45 0.712329
70 ILE ASP TRP PHE ASP GLY LYS GLU 0.45 0.712329
71 LEU PRO PHE GLU ARG ALA THR VAL MET 0.447917 0.842105
72 PRO SER ARG TRP 0.447853 0.842857
73 GLY SER ASP PRO TRP LYS 0.447674 0.871429
74 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.447059 0.743243
75 SER ASN TRP SER HIS PRO GLN PHE GLU LYS 0.446154 0.847222
76 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.444444 0.842857
77 SER SER THR ARG GLY ILE SER GLN LEU TRP 0.444444 0.849315
78 LYS ARG ARG ARG HIS PRO SER GLY 0.443182 0.887324
79 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.442529 0.915493
80 ALA PRO ALA TRP LEU PHE GLU ALA 0.437838 0.756757
81 ASP SER TRP LYS ASP GLY CYS TYR 0.437158 0.743243
82 LEU PRO PHE GLU ARG ALA THR ILE MET 0.435897 0.831169
83 LYS GLN TRP LEU VAL TRP LEU PHE LEU 0.435754 0.684932
84 TRP GLU TYR ILE PRO ASN VAL 0.431579 0.779221
85 ALA GLN ASP ILE TYR ARG ALA SER TYR 0.428571 0.733333
86 ASP GLU ASP LYS TRP ASP ASP PHE 0.427711 0.690141
87 ASP ASN TRP GLN ASN GLY THR SER 0.426136 0.760563
88 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.425532 0.835616
89 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.423645 0.864865
90 PLM GLN THR ALA ARG LYS SER THR GLY GLY TRP 0.423469 0.851351
91 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.422857 0.732394
92 THR SER ASN LEU GLN GLU GLN ILE GLY TRP 0.42246 0.756757
93 ILE ASP TRP PHE ASP GLY LYS ASP 0.422222 0.712329
94 PHE GLU ASP LEU ARG VAL SER SER PHE 0.421348 0.726027
95 PHE GLU ASP LEU ARG VAL LEU SER PHE 0.421348 0.726027
96 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.421348 0.88
97 ALA SER LEU ASN LEU PRO ALA VAL SER TRP 0.421053 0.863014
98 ASP TRP GLU ILE VAL 0.420732 0.616438
99 LYS ARG ARG ARG HIS PRO SER 0.420455 0.84507
100 FME ASP VAL GLU ALA TRP LEU 0.41989 0.605263
101 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.419355 0.75
102 LEU PRO SER PHE GLU THR ALA LEU 0.418994 0.819444
103 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.418994 0.72
104 LYS ILE LEU HIS ARG LEU LEU GLN ASP SER 0.417989 0.77027
105 ASP ILE ASN TYR TYR ALA SER GLU PRO 0.417582 0.802632
106 GLY LYS ILE SER LYS HIS TRP THR GLY ILE 0.417526 0.808219
107 01W ARG TRP THR DAB MET LEU GLY 0.416244 0.696629
108 ACE ASN TRP GLU THR PHE 0.415205 0.684932
109 LYS PRO VAL LEU ARG THR ALA 0.414773 0.847222
110 LEU PRO PHE ASP ARG THR THR ILE MET 0.414508 0.844156
111 LYS TRP LYS 0.414474 0.671429
112 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.413978 0.876712
113 PHE SER ASP PRO TRP GLY GLY 0.413043 0.859155
114 PHE GLU ASP LEU ARG LEU LEU SER PHE 0.412791 0.726027
115 TYR PRO LYS ARG ILE ALA 0.411111 0.824324
116 SER ASP PTR MET ASN MET THR PRO 0.409836 0.72619
117 ALA THR ALY ALA ALA ARG ALY SER ALA PRO 0.409091 0.861111
118 HIS HIS ALA SER PRO ARG LYS 0.408602 0.873239
119 LEU LEU TRP ASN GLY PRO MET ALA VAL 0.408163 0.766234
120 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.407821 0.875
121 ALA TRP VAL ILE PRO ALA 0.407186 0.716216
122 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.407035 0.917808
123 GLN THR ALA ARG MYK SER THR GLY GLY TRP 0.407035 0.851351
124 MET ASP TRP ASN MET HIS ALA ALA 0.406593 0.671053
125 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.40625 0.890411
126 ASN GLN LEU ALA TRP PHE ASP THR ASP LEU 0.405405 0.684932
127 ALA ARG MLZ SER ALA PRO ALA THR 0.404494 0.84
128 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.404372 0.851351
129 THR SER THR LEU GLN GLU GLN ILE GLY TRP 0.404255 0.767123
130 PHE PRO THR LYS ASP VAL ALA LEU 0.403226 0.819444
131 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.403141 0.819444
132 LEU LEU TRP ASN GLY PRO ILE ALA VAL 0.403141 0.797297
133 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.403141 0.723684
134 ALA ALA TRP LEU PHE GLU ALA 0.402299 0.60274
135 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.402116 0.75
136 GLY ASP CYS PHE SER LYS PRO ARG 0.402116 0.887324
137 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.401961 0.759036
138 ALA LEU ASP LYS TRP GLN ASN 0.401198 0.694444
139 ACE ALA ALA ARG LBZ SER ALA PRO ALA 0.4 0.887324
Similar Ligands (3D)
Ligand no: 1; Ligand: LYS ARG LYS SER ARG TRP ASP GLU THR PRO; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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