Receptor
PDB id Resolution Class Description Source Keywords
4TU9 1.99 Å NON-ENZYME: OTHER STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA HOMO SAPIENS RNA SPLICING FACTOR RNA RECOGNITION MOTIF RNA BINDING PROTBINDING PROTEIN-DNA COMPLEX
Ref.: STRUCTURE-GUIDED U2AF65 VARIANT IMPROVES RECOGNITIO SPLICING OF A DEFECTIVE PRE-MRNA. PROC.NATL.ACAD.SCI.USA V. 111 17420 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 A:405;
B:404;
A:406;
B:406;
A:404;
B:405;
 Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
none;
none;
 submit data
96.063 O4 S [O-]S...
DIO B:401;
A:403;
A:401;
A:402;
B:402;
 Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
none;
 submit data
88.105 C4 H8 O2 C1COC...
CPQ B:403;
 Invalid;
 none;
 submit data
862.056 C42 H75 N3 O15 C[C@H...
DU DU DU DU BRU DG DU P:1;
E:1;
 Valid;
Valid;
 none;
none;
 submit data
1869.9 n/a BrC=1...
GOL B:407;
A:407;
 Invalid;
Invalid;
 none;
none;
 submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4TU8 1.92 Å NON-ENZYME: OTHER STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA HOMO SAPIENS RNA SPLICING FACTOR RNA RECOGNITION MOTIF RNA BINDING PROTBINDING PROTEIN-DNA COMPLEX
Ref.: STRUCTURE-GUIDED U2AF65 VARIANT IMPROVES RECOGNITIO SPLICING OF A DEFECTIVE PRE-MRNA. PROC.NATL.ACAD.SCI.USA V. 111 17420 2014
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 4TU9 - DU DU DU DU BRU DG DU n/a n/a
2 4TU8 - DU DU DU DU BRU DA DU n/a n/a
3 4TU7 - DU DU DU DU BRU DU DU n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 4TU9 - DU DU DU DU BRU DG DU n/a n/a
2 4TU8 - DU DU DU DU BRU DA DU n/a n/a
3 4TU7 - DU DU DU DU BRU DU DU n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 4TU9 - DU DU DU DU BRU DG DU n/a n/a
2 4TU8 - DU DU DU DU BRU DA DU n/a n/a
3 4TU7 - DU DU DU DU BRU DU DU n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: DU DU DU DU BRU DG DU ; Similar ligands found: 10
No: Ligand ECFP6 Tc MDL keys Tc
1 DU DU DU DU BRU DG DU 1 1
2 3PD UM3 0.798319 0.940476
3 DU DU DU DU BRU DA DU 0.671329 0.896552
4 DU DU DU DU BRU DU DU 0.648 0.813953
5 CGP 0.482759 0.896552
6 DT MA7 DT 0.45283 0.833333
7 DGI 0.416667 0.818182
8 DGP 0.414062 0.827586
9 DG 0.414062 0.827586
10 UM3 0.411765 0.752941
Similar Ligands (3D)
Ligand no: 1; Ligand: DU DU DU DU BRU DG DU ; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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