Receptor
PDB id Resolution Class Description Source Keywords
4UEC 2.4 Å NON-ENZYME: TRANSCRIPT_TRANSLATE COMPLEX OF D. MELANOGASTER EIF4E WITH EIF4G AND CAP ANALOG DROSOPHILA MELANOGASTER TRANSLATION GENE REGULATION CAP BINDING PROTEIN 4E BINDINPROTEIN TRANSLATION INITIATION
Ref.: MOLECULAR ARCHITECTURE OF 4E-BP TRANSLATIONAL INHIB BOUND TO EIF4E. MOL.CELL V. 57 1074 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MGT A:1237;
C:1237;
Valid;
Valid;
none;
none;
submit data
539.223 C11 H20 N5 O14 P3 CN1CN...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4UEC 2.4 Å NON-ENZYME: TRANSCRIPT_TRANSLATE COMPLEX OF D. MELANOGASTER EIF4E WITH EIF4G AND CAP ANALOG DROSOPHILA MELANOGASTER TRANSLATION GENE REGULATION CAP BINDING PROTEIN 4E BINDINPROTEIN TRANSLATION INITIATION
Ref.: MOLECULAR ARCHITECTURE OF 4E-BP TRANSLATIONAL INHIB BOUND TO EIF4E. MOL.CELL V. 57 1074 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 4UEC - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 4UEC - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 4UEC - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
2 5T48 - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MGT; Similar ligands found: 16
No: Ligand ECFP6 Tc MDL keys Tc
1 MGT 1 1
2 M7G 0.910256 1
3 8GT 0.557895 0.914634
4 TPG 0.55 0.920455
5 G8D 0.505155 0.914634
6 M7M 0.49505 0.963855
7 CTP 0.453608 0.829268
8 HF4 0.453608 0.829268
9 UTP 0.447917 0.780488
10 6G0 0.438095 0.837209
11 8DG 0.433962 0.872093
12 01G 0.433628 0.791209
13 H6Y 0.428571 0.77907
14 MGP 0.428571 0.837209
15 8GM 0.414141 0.902439
16 GTP 0.411215 0.823529
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4UEC; Ligand: MGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 4uec.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 4UEC; Ligand: MGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4uec.bio2) has 10 residues
No: Leader PDB Ligand Sequence Similarity
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