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Receptor
PDB id Resolution Class Description Source Keywords
4X60 2.35 Å EC: 2.1.1.- CRYSTAL STRUCTURE OF PRMT5:MEP50 WITH EPZ015666 AND SINEFUNG HOMO SAPIENS PROTEIN-INHIBITOR COMPLEX PROTEIN ARGININE METHYLTRANSFERASTRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: A SELECTIVE INHIBITOR OF PRMT5 WITH IN VIVO AND IN POTENCY IN MCL MODELS. NAT.CHEM.BIOL. V. 11 432 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
3XV A:702;
Valid;
none;
Kd < 1 nM
383.444 C20 H25 N5 O3 c1ccc...
GOL A:704;
A:703;
A:705;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SFG A:701;
Valid;
none;
submit data
381.387 C15 H23 N7 O5 c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4X60 2.35 Å EC: 2.1.1.- CRYSTAL STRUCTURE OF PRMT5:MEP50 WITH EPZ015666 AND SINEFUNG HOMO SAPIENS PROTEIN-INHIBITOR COMPLEX PROTEIN ARGININE METHYLTRANSFERASTRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: A SELECTIVE INHIBITOR OF PRMT5 WITH IN VIVO AND IN POTENCY IN MCL MODELS. NAT.CHEM.BIOL. V. 11 432 2015
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 5EMJ ic50 = 33 nM 5QJ C25 H27 N5 O Cn1cnc2c1c....
2 5EML ic50 = 23 nM 5QK C23 H25 N3 O3 c1ccc2c(c1....
3 4X60 Kd < 1 nM 3XV C20 H25 N5 O3 c1ccc2c(c1....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 54 families.
1 5EMJ ic50 = 33 nM 5QJ C25 H27 N5 O Cn1cnc2c1c....
2 5EML ic50 = 23 nM 5QK C23 H25 N3 O3 c1ccc2c(c1....
3 4X60 Kd < 1 nM 3XV C20 H25 N5 O3 c1ccc2c(c1....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 47 families.
1 5EMJ ic50 = 33 nM 5QJ C25 H27 N5 O Cn1cnc2c1c....
2 5EML ic50 = 23 nM 5QK C23 H25 N3 O3 c1ccc2c(c1....
3 4X60 Kd < 1 nM 3XV C20 H25 N5 O3 c1ccc2c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 3XV; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 3XV 1 1
2 5QK 0.415929 0.8
Ligand no: 2; Ligand: SFG; Similar ligands found: 231
No: Ligand ECFP6 Tc MDL keys Tc
1 SFG 1 1
2 0UM 0.689655 0.887324
3 SAI 0.654762 0.940298
4 SA8 0.642857 0.9
5 SAH 0.635294 0.954545
6 EEM 0.62069 0.875
7 5X8 0.619048 0.924242
8 S7M 0.606742 0.875
9 ADN 0.597222 0.850746
10 RAB 0.597222 0.850746
11 XYA 0.597222 0.850746
12 5CD 0.594595 0.863636
13 5N5 0.581081 0.850746
14 62X 0.574468 0.84
15 A4D 0.573333 0.850746
16 K15 0.568421 0.863014
17 DTA 0.564103 0.84058
18 6RE 0.560976 0.833333
19 SAM 0.555556 0.875
20 EP4 0.551282 0.802817
21 KB1 0.55102 0.887324
22 M2T 0.544304 0.780822
23 SMM 0.537634 0.84
24 MTA 0.5375 0.826087
25 AMP 0.53012 0.77027
26 A 0.53012 0.77027
27 ZAS 0.53012 0.816901
28 LMS 0.53012 0.678571
29 J7C 0.529412 0.84507
30 3DH 0.52439 0.826087
31 GJV 0.523256 0.821918
32 SON 0.522727 0.813333
33 0XU 0.522222 0.938462
34 SRP 0.521277 0.813333
35 SSA 0.521277 0.697674
36 AOC 0.517647 0.826087
37 CA0 0.516854 0.776316
38 5AL 0.516129 0.786667
39 DSZ 0.515464 0.717647
40 AMO 0.515464 0.813333
41 GSU 0.515152 0.738095
42 KH3 0.514286 0.851351
43 ABM 0.511628 0.75
44 A2D 0.511628 0.75
45 A3N 0.511628 0.814286
46 A5A 0.510638 0.682353
47 5CA 0.510417 0.697674
48 SRA 0.505882 0.730769
49 S4M 0.505747 0.792208
50 A3S 0.505618 0.895522
51 A7D 0.505618 0.882353
52 AN2 0.505618 0.74026
53 GAP 0.505376 0.776316
54 54H 0.5 0.666667
55 M33 0.5 0.74026
56 LAD 0.5 0.818182
57 A12 0.5 0.766234
58 ADX 0.5 0.678571
59 Y3J 0.5 0.80303
60 DSH 0.5 0.871429
61 LSS 0.5 0.681818
62 KAA 0.5 0.712644
63 VMS 0.5 0.666667
64 AP2 0.5 0.766234
65 BA3 0.5 0.75
66 SXZ 0.49505 0.875
67 ME8 0.49505 0.775
68 AHX 0.494949 0.759494
69 53H 0.494845 0.659091
70 DAL AMP 0.494845 0.786667
71 TSB 0.494845 0.674419
72 G5A 0.494624 0.697674
73 50T 0.494505 0.74026
74 ADP 0.494382 0.75
75 5AS 0.494382 0.640449
76 AP5 0.494382 0.75
77 B4P 0.494382 0.75
78 F0P 0.490909 0.9
79 GEK 0.489796 0.913043
80 8QN 0.489796 0.786667
81 AT4 0.488889 0.721519
82 5AD 0.486842 0.828125
83 PAJ 0.484848 0.728395
84 52H 0.484536 0.659091
85 AU1 0.483516 0.730769
86 MAO 0.483146 0.782051
87 A3G 0.482759 0.882353
88 NEC 0.482759 0.797101
89 3AM 0.482353 0.733333
90 YAP 0.480769 0.802632
91 7D7 0.480519 0.794118
92 NB8 0.480392 0.782051
93 TXA 0.480392 0.766234
94 NVA LMS 0.48 0.693182
95 ATF 0.479167 0.721519
96 HEJ 0.478261 0.75
97 A3T 0.478261 0.852941
98 ACP 0.478261 0.753247
99 ATP 0.478261 0.75
100 7MD 0.476636 0.775
101 YSA 0.47619 0.697674
102 XAH 0.47619 0.775
103 9ZA 0.474747 0.746835
104 9ZD 0.474747 0.746835
105 APR 0.473118 0.773333
106 5FA 0.473118 0.75
107 AR6 0.473118 0.773333
108 AQP 0.473118 0.75
109 PRX 0.473118 0.753247
110 APC 0.473118 0.766234
111 WAQ 0.470588 0.815789
112 4AD 0.47 0.802632
113 NSS 0.47 0.697674
114 F2R 0.469565 0.756098
115 A5D 0.468085 0.84058
116 RBY 0.468085 0.789474
117 ADV 0.468085 0.789474
118 AD9 0.468085 0.730769
119 AGS 0.468085 0.7125
120 SAP 0.468085 0.7125
121 ADP PO3 0.468085 0.77027
122 MHZ 0.467391 0.782051
123 FA5 0.466667 0.813333
124 PTJ 0.466019 0.7375
125 00A 0.465347 0.746835
126 8X1 0.464646 0.693182
127 D3Y 0.464646 0.869565
128 VRT 0.463158 0.871429
129 GA7 0.462963 0.74359
130 LEU LMS 0.460784 0.674157
131 S8M 0.46 0.859155
132 OOB 0.46 0.786667
133 ADP VO4 0.459184 0.74026
134 VO4 ADP 0.459184 0.74026
135 T99 0.458333 0.721519
136 ANP 0.458333 0.730769
137 TAT 0.458333 0.721519
138 ACQ 0.458333 0.753247
139 B5V 0.456311 0.766234
140 AAT 0.453608 0.847222
141 2AM 0.453488 0.723684
142 8PZ 0.45283 0.697674
143 FYA 0.451923 0.786667
144 YLC 0.451327 0.797468
145 DLL 0.45098 0.786667
146 A3P 0.450549 0.746667
147 YLP 0.45045 0.777778
148 A22 0.45 0.74026
149 ARG AMP 0.449541 0.765432
150 ADP ALF 0.44898 0.7125
151 ALF ADP 0.44898 0.7125
152 2VA 0.446809 0.828571
153 OAD 0.446602 0.776316
154 3UK 0.446602 0.776316
155 80F 0.445378 0.73494
156 TYR AMP 0.444444 0.802632
157 6YZ 0.444444 0.753247
158 IOT 0.443478 0.768293
159 9SN 0.443396 0.7375
160 PR8 0.442308 0.807692
161 P5A 0.442308 0.704545
162 7D5 0.44186 0.714286
163 A1R 0.441176 0.769231
164 7C5 0.440367 0.797297
165 TT8 0.44 0.926471
166 YLA 0.439655 0.777778
167 YLB 0.438596 0.777778
168 3OD 0.438095 0.776316
169 9K8 0.438095 0.655556
170 BIS 0.438095 0.725
171 1ZZ 0.438095 0.753086
172 NVA 2AD 0.4375 0.859155
173 MAP 0.435644 0.7125
174 MYR AMP 0.433962 0.753086
175 NAI 0.433628 0.725
176 SO8 0.43299 0.816901
177 9X8 0.432692 0.734177
178 A6D 0.432692 0.74359
179 25A 0.431373 0.75
180 5SV 0.431373 0.7375
181 TYM 0.429825 0.813333
182 WSA 0.429825 0.705882
183 LAQ 0.428571 0.753086
184 3NZ 0.428571 0.833333
185 A3R 0.427184 0.769231
186 ADQ 0.427184 0.753247
187 8Q2 0.426087 0.674157
188 7MC 0.426087 0.756098
189 B5Y 0.425926 0.75641
190 B5M 0.425926 0.75641
191 LPA AMP 0.424779 0.753086
192 48N 0.424779 0.759494
193 JB6 0.424528 0.746835
194 PPS 0.424242 0.658824
195 AYB 0.423729 0.768293
196 PAP 0.42268 0.736842
197 OVE 0.422222 0.696203
198 3AD 0.421687 0.863636
199 4YB 0.419643 0.72093
200 A2P 0.419355 0.733333
201 CMP 0.419355 0.753425
202 2BA 0.419355 0.743243
203 ADP BMA 0.419048 0.753247
204 4UV 0.418182 0.75641
205 AHZ 0.415929 0.731707
206 QQX 0.41573 0.670886
207 A A 0.415094 0.75
208 AP0 0.413793 0.695122
209 ATP A A A 0.412844 0.76
210 SP1 0.411111 0.705128
211 QQY 0.411111 0.679487
212 ACK 0.411111 0.716216
213 RP1 0.411111 0.705128
214 AFH 0.410714 0.728395
215 4UU 0.410714 0.75641
216 DND 0.408696 0.766234
217 NXX 0.408696 0.766234
218 TXD 0.408696 0.725
219 7D3 0.408602 0.696203
220 CC5 0.407407 0.876923
221 25L 0.407407 0.74026
222 TAD 0.40708 0.75
223 DQV 0.40708 0.763158
224 AMP DBH 0.405405 0.753247
225 TXE 0.405172 0.725
226 AF3 ADP 3PG 0.405172 0.75
227 OMR 0.405172 0.743902
228 MTP 0.404762 0.72973
229 N0B 0.401575 0.777778
230 V3L 0.4 0.773333
231 YLY 0.4 0.768293
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4X60; Ligand: 3XV; Similar sites found with APoc: 406
This union binding pocket(no: 1) in the query (biounit: 4x60.bio1) has 41 residues
No: Leader PDB Ligand Sequence Similarity
1 3S1S SAH 1.55039
2 5W7R SAH 1.6317
3 3HDY FAD 2.01511
4 3HDY FDA 2.01511
5 3HDY GDU 2.01511
6 4RDH AMP 2.08333
7 4RDI ATP 2.08333
8 1VQW FAD 2.18818
9 2GVC FAD 2.23714
10 2GV8 FAD 2.23714
11 1TV5 N8E 2.25734
12 3PT9 SAH 2.28571
13 2JHP SAH 2.28571
14 4TXI FAD 2.28571
15 4AP3 NAP 2.28571
16 4AP3 FAD 2.28571
17 1XTP SAI 2.3622
18 4XCZ T3Q 2.39808
19 4UCI SAM 2.40964
20 1FP1 SAH 2.41935
21 2VDV SAM 2.43902
22 2DPM SAM 2.46479
23 3WMX NAD 2.51397
24 3TKY SAH 2.57143
25 2Q28 ADP 2.57143
26 2RGJ FAD 2.57143
27 3GWZ SAH 2.71003
28 3GXO SAH 2.71003
29 1V59 NAD 2.71967
30 2BRY FAD 2.8169
31 1LVL NAD 2.83843
32 5WP4 SAH 2.85714
33 3TDC 0EU 2.85714
34 1RSG FAD 2.90698
35 2NPX NAD 2.90828
36 1KYQ NAD 2.91971
37 3MAG SAH 2.9316
38 5U19 SAH 2.93255
39 5U19 827 2.93255
40 5Z75 NAD 3.0581
41 5OCM 9RH 3.09278
42 2ZIF SAM 3.10078
43 5WGR FAD 3.10078
44 5Y77 FAD 3.14286
45 2BO4 FLC 3.14286
46 3S5W FAD 3.14286
47 3GD4 NAD 3.14286
48 5MZI FYK 3.14286
49 5MZI FAD 3.14286
50 4RPL 3UC 3.14286
51 4RPL FAD 3.14286
52 2BGM NAJ 3.23741
53 1YXM ADE 3.30033
54 4AZW SAM 3.39703
55 1GPE FAD 3.40716
56 5GT9 NAP 3.42205
57 2AOT SAH 3.42466
58 1NAA ABL 3.42857
59 5BUK FAD 3.42857
60 1NAA 6FA 3.42857
61 3KJI ADP 3.54331
62 1COY AND 3.5503
63 3LCV SAM 3.55872
64 4DMG SAM 3.56234
65 4Y9D NAI 3.60656
66 4D79 ATP 3.62319
67 4KIB SAH 3.64146
68 3JWH SAH 3.68664
69 3SQP FAD 3.71429
70 6ER9 FAD 3.71429
71 3SUC ATP 3.71429
72 6ER9 NAP 3.71429
73 2VT3 ATP 3.72093
74 2WD7 VGD 3.73134
75 3LST SAH 3.73563
76 2PK3 A2R 3.73832
77 4A7W GTP 3.75
78 1NW5 SAM 3.76176
79 5XNC MTA 3.77358
80 4RL4 PPV 3.77358
81 1DL5 SAH 3.78549
82 2A14 SAH 3.80228
83 5LX9 OLB 3.87324
84 5X62 SAH 3.87597
85 6B3A SAM 3.87597
86 6F97 FAD 3.87597
87 4NBW NAD 3.89105
88 3ICT ADP 3.91156
89 3ICS ADP 3.91156
90 3ICT FAD 3.91156
91 3ICR FAD 3.91156
92 5BVA FAD 3.91198
93 2O07 MTA 3.94737
94 2O07 SPD 3.94737
95 4N49 SAM 4
96 5X7Q GLC GLC GLC GLC 4
97 5X7Q GLC GLC GLC 4
98 2WPF FAD 4
99 2WPF WPF 4
100 3UCL FAD 4
101 3UCL CYH 4
102 3UCL NAP 4
103 4K5S FAD 4
104 3PGU OLA 4
105 3V1U NAD 4
106 4YNU FAD 4.02802
107 1GZ6 NAI 4.07523
108 5F2K OCA 4.07609
109 5F2K SAH 4.07609
110 6B92 SAH 4.08163
111 1G55 SAH 4.08163
112 6M8N MLI 4.11622
113 4CS9 AMP 4.2328
114 1JG3 ADN 4.25532
115 5XLX SAH 4.25532
116 6GKV SAH 4.2735
117 2EJU SAH 4.28571
118 5KOK SAH 4.28571
119 5KOK R9T 4.28571
120 1I9G SAM 4.28571
121 5KOK S9T 4.28571
122 1GY8 NAD 4.28571
123 2XVF FAD 4.28571
124 1GET NAP 4.28571
125 1GET FAD 4.28571
126 5I7A 68Q 4.29448
127 5OVK NDP 4.29688
128 3EVF GTA 4.33213
129 3EVF SAH 4.33213
130 3ELW SAM 4.33333
131 3ELW GP3 4.33333
132 2WA2 SAM 4.34783
133 4YAC NAI 4.3771
134 4URF NAD 4.43548
135 4QAR ADE 4.47761
136 5BW4 SAM 4.49438
137 4DYG MES 4.5082
138 4NEC SAH 4.54545
139 1M0W ANP 4.57143
140 2DKH FAD 4.57143
141 3OU2 SAH 4.58716
142 3UOY NAP 4.58716
143 3UOY FAD 4.58716
144 1JE1 GMP 4.66102
145 1Z3C SA8 4.69799
146 1JQ3 AAT 4.72973
147 6GFK SAH 4.78088
148 2YY7 NAD 4.80769
149 5ZZ6 ADP 4.80769
150 1PJS NAD 4.85714
151 3GEG NAD 4.8583
152 4E70 N7I 4.89691
153 5THY SAH 4.93827
154 5THZ SAH 4.93827
155 5NMX FAD 4.94118
156 2GN4 UD1 4.94186
157 2GN4 NDP 4.94186
158 4PIO SAH 4.95356
159 4PIO AVI 4.95356
160 1ZEM NAD 4.96183
161 2RIF AMP 4.96454
162 5FA8 SAM 4.96894
163 5YF1 SFG 4.97238
164 5YF1 8V0 4.97238
165 4USQ FAD 4.98615
166 3BGD SAH 5
167 3BGD PM6 5
168 1E6W NAD 5
169 6C8R SAH 5.01319
170 6C8R EQV 5.01319
171 1WVG APR 5.01393
172 3MQ2 SAH 5.04587
173 5E9W SAH 5.12821
174 4KRI SAH 5.14286
175 3OJO NAD 5.14286
176 5JJR SAH 5.15695
177 5ULP KB1 5.22388
178 2JK0 ASP 5.23077
179 5CUQ NSC 5.24345
180 2XVM SAH 5.27132
181 3E1T FAD 5.27344
182 5YJI SAH 5.28169
183 5YJI 8WO 5.28169
184 5YEC ATP 5.29412
185 5F7J ADE 5.3125
186 5X68 FAD 5.37084
187 3VSE SAH 5.42857
188 4EUE NAI 5.42857
189 5U8U FAD 5.42857
190 4UP4 NDG 5.42857
191 2XVE FAD 5.42857
192 3C3Y SAH 5.48523
193 5MGZ SAH 5.50847
194 2P41 SAH 5.57377
195 1BC5 SAH 5.57621
196 2EWM NAD 5.62249
197 5YJF SAH 5.6338
198 5YJF 8WO 5.6338
199 5J5Z FAD 5.64516
200 2Q8G AZX 5.65111
201 3GCZ SAM 5.67376
202 6FDF SAH 5.68862
203 1KYZ SAH 5.71429
204 1KYZ FER 5.71429
205 2CHG ANP 5.75221
206 3EVG SAH 5.81818
207 1JQD SAH 5.82192
208 1JQD HSM 5.82192
209 3WCZ CIT 5.84416
210 4TQG NDP 5.88235
211 5E1M SAH 5.89147
212 5E1M PRO PRO LYS ARG ILE ALA 5.89147
213 3H2B SAH 5.91133
214 6ECT SAM 5.919
215 3KP6 SAL 5.96026
216 5GWX SAR 5.98592
217 5GWX SAM 5.98592
218 4DCM SAM 6
219 3IHG FAD 6
220 1U2Z SAH 6
221 3FPF MTA 6.04027
222 3FPF TNA 6.04027
223 5F8F SFG 6.04651
224 2PT9 2MH 6.23053
225 2PT9 S4M 6.23053
226 1L1E SAH 6.27178
227 2PX8 SAH 6.3197
228 2JBM SRT 6.35452
229 1LSS NAD 6.42857
230 5LOG SAH 6.43777
231 3FZG SAM 6.5
232 4A6D SAM 6.51558
233 4EIL FOL 6.5371
234 3LKZ SFG 6.54206
235 5W7K SAH 6.73077
236 1SQF SAM 6.75991
237 3G5S FAD 6.77201
238 5KVA SAM 6.83453
239 5GWT NAD 6.83453
240 1X87 NAD 6.85714
241 1VMK GUN 6.85921
242 3TKA SAM 6.91643
243 5ERG SAM 7.04961
244 2I7C AAT 7.06714
245 5GM1 SAH 7.07071
246 5HJM MTA 7.14286
247 3C6K MTA 7.14286
248 3C6K SPD 7.14286
249 3K5I ADP 7.19603
250 3Q87 SAM 7.2
251 4II2 ATP 7.22892
252 1ODJ GMP 7.23404
253 2ZFU SAH 7.44186
254 1MO9 KPC 7.45698
255 1MO9 FAD 7.45698
256 5E72 SAM 7.51445
257 2BJ4 OHT 7.53968
258 4RJD TFP 7.57576
259 1E1M FAD 7.6087
260 1E1M NAP 7.6087
261 5JE0 AZ8 7.69231
262 5JE0 SAH 7.69231
263 5ZQ4 AMP 7.69231
264 1XHC FAD 7.71429
265 4XFR CIT 7.72834
266 2UYQ SAM 7.74194
267 1GEG GLC 7.8125
268 1GEG NAD 7.8125
269 1ZGA SAH 7.84314
270 6C5B SAH 7.91789
271 1VE3 SAM 7.92952
272 5JGL SAM 7.95848
273 1I1N SAH 7.9646
274 4KRG SAH 8
275 6ECU SAH 8.22785
276 6ECW SAH 8.25397
277 4D04 FAD 8.28571
278 4D04 NAP 8.28571
279 3PFG SAM 8.36502
280 3PFG TLO 8.36502
281 2HNK SAH 8.3682
282 3RKR NAP 8.39695
283 5UFN SAH 8.40336
284 4B3J COA 8.43672
285 4POO SAM 8.5
286 5MPT SAH 8.57143
287 1KO8 6PG 8.57143
288 3KLJ FAD 8.57143
289 4BLW SAH 8.65052
290 4BLW AMP 8.65052
291 2Q46 NAP 8.69565
292 5BSZ SAH 8.8
293 4R6W PC 8.91473
294 4R6W SAH 8.91473
295 2YX1 SFG 8.92857
296 1XCL SAH 8.93617
297 5FTW SAH 8.98438
298 2BZG SAH 9.05172
299 3VYW SAM 9.09091
300 1XDS SAM 9.14286
301 1QZZ SAM 9.14286
302 4YMH SAH 9.16667
303 3IA4 MTX 9.25926
304 1Q0S SAH 9.26641
305 2PWY SAH 9.30233
306 4OBW SAM 9.33852
307 1E6E FAD 9.375
308 3MCT SAH 9.42761
309 1UAY ADN 9.50413
310 2FR6 URI 9.58904
311 2FR6 CTN 9.58904
312 5W7M SAH 9.61539
313 3DXY SAM 9.63303
314 5ICE SAH 9.65909
315 5ICE 2H4 9.65909
316 5JCM FAD 9.71429
317 5JCM NAD 9.71429
318 5JCM ISD 9.71429
319 3BRE C2E 9.71429
320 2HMT NAI 9.72222
321 6BQ6 TER 9.96979
322 4V3C C 10.0515
323 1UZN NAP 10.1215
324 5CHR 4NC 10.219
325 3G2O SAM 10.3679
326 1X14 NAD 10.4738
327 5AN1 GSH 10.5023
328 1FP2 SAH 10.5114
329 1FP2 HMO 10.5114
330 1P1C SAH 10.5528
331 3T7S SAM 10.8209
332 4D7E FAD 10.8571
333 3BXO SAM 10.8787
334 5K7U SAM 10.8883
335 1QAN SAH 11.0656
336 5ZJ5 NAI 11.1111
337 2CDU ADP 11.1429
338 2PXX SAH 11.1628
339 3QOX SAH 11.2676
340 3A25 SAM 11.2957
341 3L9W GSH 11.4286
342 3L9W AMP 11.4286
343 3H8V ATP 11.6438
344 5ICK FEZ 11.7904
345 5DNK SAH 12
346 5IL1 SAM 12
347 5L95 AMP 12.1864
348 3U4C NDP 12.2857
349 2HIM ASP 12.2905
350 4CQM NAP 12.2951
351 3P2E SAH 12.4444
352 3NUG NAD 12.5506
353 3WV8 ATP 12.844
354 2YVJ NAI 12.844
355 1KPG SAH 12.892
356 1ELI PYC 13.1105
357 3KIF GDL 13.2075
358 4KXQ APR 13.3333
359 1R18 SAH 13.6564
360 1TPY SAH 13.9373
361 1KPH SAH 13.9373
362 6DUB SAH 13.964
363 2QA1 FAD 14
364 1Y8Q ATP 14.1618
365 5MW4 5JU 14.3713
366 3KIH GDL 14.433
367 4YUW 4JU 14.4737
368 4YUW S4M 14.4737
369 3P9C SAH 14.5714
370 6F5Z SAH 14.7541
371 3VZS NAP 14.786
372 3HVJ 705 14.9321
373 5N5D SAM 15.0442
374 3QXV MTX 15.0794
375 4PNE SAH 15.894
376 2BOS GLA GAL GLC 16.1765
377 2BOS GLA GAL GLC NBU 16.1765
378 1W6U NAP 16.2252
379 1W73 NAP 16.2252
380 1W8D NAP 16.2252
381 3A27 SAM 16.5441
382 5A7C 5D4 16.8142
383 3AD8 NAD 17.1717
384 3MB5 SAM 17.2549
385 6FS0 E4W 18.239
386 5ZCO CHD 19.1781
387 5W97 CHD 19.1781
388 5Z84 CHD 19.1781
389 5DXA SFG 19.7708
390 5DX0 SFG 19.7708
391 5DWQ SFG 19.7708
392 5DX1 SFG 19.7708
393 6ARJ BW4 19.7708
394 6ARJ SAH 19.7708
395 5DX8 SFG 19.7708
396 1G60 SAM 20
397 1L3I SAH 20.3125
398 4LWP SAH 20.9239
399 4I90 CHT 23.1023
400 2Y69 CHD 23.75
401 5FWA J7C 23.991
402 4XUC SAM 27.9817
403 4XUC 43G 27.9817
404 5E8J SAH 29.5455
405 5FUB SAH 29.6736
406 1F3L SAH 36.1371
Pocket No.: 2; Query (leader) PDB : 4X60; Ligand: SFG; Similar sites found with APoc: 404
This union binding pocket(no: 2) in the query (biounit: 4x60.bio1) has 40 residues
No: Leader PDB Ligand Sequence Similarity
1 3S1S SAH 1.55039
2 5W7R SAH 1.6317
3 3HDY FAD 2.01511
4 3HDY FDA 2.01511
5 3HDY GDU 2.01511
6 4RDH AMP 2.08333
7 4RDI ATP 2.08333
8 1VQW FAD 2.18818
9 2GVC FAD 2.23714
10 2GV8 FAD 2.23714
11 1TV5 N8E 2.25734
12 3PT9 SAH 2.28571
13 2JHP SAH 2.28571
14 4TXI FAD 2.28571
15 4AP3 NAP 2.28571
16 4AP3 FAD 2.28571
17 1XTP SAI 2.3622
18 4XCZ T3Q 2.39808
19 4UCI SAM 2.40964
20 1FP1 SAH 2.41935
21 2VDV SAM 2.43902
22 2DPM SAM 2.46479
23 3WMX NAD 2.51397
24 3TKY SAH 2.57143
25 2Q28 ADP 2.57143
26 2RGJ FAD 2.57143
27 5VN0 NAI 2.57143
28 3GWZ SAH 2.71003
29 3GXO SAH 2.71003
30 1V59 NAD 2.71967
31 2BRY FAD 2.8169
32 1LVL NAD 2.83843
33 3TDC 0EU 2.85714
34 5WP4 SAH 2.85714
35 2NPX NAD 2.90828
36 1KYQ NAD 2.91971
37 3MAG SAH 2.9316
38 5U19 SAH 2.93255
39 5U19 827 2.93255
40 5Z75 NAD 3.0581
41 5OCM 9RH 3.09278
42 2ZIF SAM 3.10078
43 5WGR FAD 3.10078
44 5Y77 FAD 3.14286
45 3GD4 NAD 3.14286
46 2BO4 FLC 3.14286
47 3S5W FAD 3.14286
48 6F92 MVL 3.14286
49 5MZI FAD 3.14286
50 5MZI FYK 3.14286
51 4RPL FAD 3.14286
52 4RPL 3UC 3.14286
53 2OCI TYC 3.14961
54 2BGM NAJ 3.23741
55 1YXM ADE 3.30033
56 4AZW SAM 3.39703
57 5GT9 NAP 3.42205
58 2AOT SAH 3.42466
59 1NAA ABL 3.42857
60 1NAA 6FA 3.42857
61 5BUK FAD 3.42857
62 3KJI ADP 3.54331
63 3LCV SAM 3.55872
64 4DMG SAM 3.56234
65 4Y9D NAI 3.60656
66 4D79 ATP 3.62319
67 4KIB SAH 3.64146
68 3JWH SAH 3.68664
69 3SQP FAD 3.71429
70 6ER9 FAD 3.71429
71 6ER9 NAP 3.71429
72 2VT3 ATP 3.72093
73 2WD7 VGD 3.73134
74 3LST SAH 3.73563
75 2PK3 A2R 3.73832
76 1NW5 SAM 3.76176
77 5XNC MTA 3.77358
78 4RL4 PPV 3.77358
79 1DL5 SAH 3.78549
80 2A14 SAH 3.80228
81 5LX9 OLB 3.87324
82 5X62 SAH 3.87597
83 6B3A SAM 3.87597
84 4NBW NAD 3.89105
85 4EMI NAD 3.90244
86 3ICT ADP 3.91156
87 3ICS ADP 3.91156
88 3ICT FAD 3.91156
89 5BVA FAD 3.91198
90 2O07 MTA 3.94737
91 2O07 SPD 3.94737
92 4N49 SAM 4
93 5X7Q GLC GLC GLC GLC 4
94 5X7Q GLC GLC GLC 4
95 2WPF FAD 4
96 2WPF WPF 4
97 3UCL NAP 4
98 3UCL CYH 4
99 3UCL FAD 4
100 4K5S FAD 4
101 3V1U NAD 4
102 1GZ6 NAI 4.07523
103 5F2K SAH 4.07609
104 5F2K OCA 4.07609
105 6B92 SAH 4.08163
106 1G55 SAH 4.08163
107 6M8N MLI 4.11622
108 4CS9 AMP 4.2328
109 1JG3 ADN 4.25532
110 5XLX SAH 4.25532
111 6GKV SAH 4.2735
112 2EJU SAH 4.28571
113 5KOK SAH 4.28571
114 1I9G SAM 4.28571
115 5KOK R9T 4.28571
116 5KOK S9T 4.28571
117 1GY8 NAD 4.28571
118 5JDI 6JO 4.28571
119 1GET NAP 4.28571
120 1GET FAD 4.28571
121 2XVF FAD 4.28571
122 5I7A 68Q 4.29448
123 5OVK NDP 4.29688
124 3EVF GTA 4.33213
125 3EVF SAH 4.33213
126 3ELW SAM 4.33333
127 3ELW GP3 4.33333
128 2WA2 SAM 4.34783
129 4YAC NAI 4.3771
130 4URF NAD 4.43548
131 4QAR ADE 4.47761
132 5BW4 SAM 4.49438
133 4DYG MES 4.5082
134 4NEC SAH 4.54545
135 2DKH FAD 4.57143
136 3OU2 SAH 4.58716
137 3UOY NAP 4.58716
138 3UOY FAD 4.58716
139 1JE1 GMP 4.66102
140 1Z3C SA8 4.69799
141 1JQ3 AAT 4.72973
142 6GFK SAH 4.78088
143 2YY7 NAD 4.80769
144 5ZZ6 ADP 4.80769
145 1PJS NAD 4.85714
146 3GEG NAD 4.8583
147 4E70 N7I 4.89691
148 5THY SAH 4.93827
149 5THZ SAH 4.93827
150 5NMX FAD 4.94118
151 2GN4 UD1 4.94186
152 2GN4 NDP 4.94186
153 4PIO SAH 4.95356
154 4PIO AVI 4.95356
155 1ZEM NAD 4.96183
156 2RIF AMP 4.96454
157 5FA8 SAM 4.96894
158 5YF1 SFG 4.97238
159 5YF1 8V0 4.97238
160 4USQ FAD 4.98615
161 3BGD SAH 5
162 3BGD PM6 5
163 1E6W NAD 5
164 6C8R SAH 5.01319
165 6C8R EQV 5.01319
166 1WVG APR 5.01393
167 3MQ2 SAH 5.04587
168 5E9W SAH 5.12821
169 4KRI SAH 5.14286
170 3OJO NAD 5.14286
171 5JJR SAH 5.15695
172 5ULP KB1 5.22388
173 2JK0 ASP 5.23077
174 5CUQ NSC 5.24345
175 2XVM SAH 5.27132
176 3E1T FAD 5.27344
177 5YJI 8WO 5.28169
178 5YJI SAH 5.28169
179 5YEC ATP 5.29412
180 5F7J ADE 5.3125
181 5X68 FAD 5.37084
182 3VSE SAH 5.42857
183 4EUE NAI 5.42857
184 5U8U FAD 5.42857
185 4UP4 NDG 5.42857
186 2XVE FAD 5.42857
187 3C3Y SAH 5.48523
188 5MGZ SAH 5.50847
189 2P41 SAH 5.57377
190 1BC5 SAH 5.57621
191 2EWM NAD 5.62249
192 5YJF SAH 5.6338
193 5YJF 8WO 5.6338
194 5J5Z FAD 5.64516
195 2Q8G AZX 5.65111
196 3GCZ SAM 5.67376
197 6FDF SAH 5.68862
198 1KYZ SAH 5.71429
199 1KYZ FER 5.71429
200 5BJX NAD 5.71429
201 5BJX UDP 5.71429
202 2CHG ANP 5.75221
203 3EVG SAH 5.81818
204 1JQD SAH 5.82192
205 1JQD HSM 5.82192
206 3WCZ CIT 5.84416
207 4TQG NDP 5.88235
208 5E1M PRO PRO LYS ARG ILE ALA 5.89147
209 5E1M SAH 5.89147
210 3H2B SAH 5.91133
211 6ECT SAM 5.919
212 3KP6 SAL 5.96026
213 5GWX SAR 5.98592
214 5GWX SAM 5.98592
215 4DCM SAM 6
216 3IHG FAD 6
217 1U2Z SAH 6
218 5O42 BGC 6
219 5O42 NAD 6
220 5O42 9JW 6
221 3FPF MTA 6.04027
222 3FPF TNA 6.04027
223 5F8F SFG 6.04651
224 2PT9 2MH 6.23053
225 2PT9 S4M 6.23053
226 1L1E SAH 6.27178
227 2PX8 SAH 6.3197
228 2JBM SRT 6.35452
229 2WNF CG3 A2G GAL 6.37584
230 1LSS NAD 6.42857
231 5LOG SAH 6.43777
232 3FZG SAM 6.5
233 4A6D SAM 6.51558
234 4EIL FOL 6.5371
235 3LKZ SFG 6.54206
236 4TM3 FAD 6.57143
237 5W7K SAH 6.73077
238 1SQF SAM 6.75991
239 3G5S FAD 6.77201
240 5KVA SAM 6.83453
241 5GWT NAD 6.83453
242 1X87 NAD 6.85714
243 1VMK GUN 6.85921
244 3TKA SAM 6.91643
245 5ERG SAM 7.04961
246 2I7C AAT 7.06714
247 5GM1 SAH 7.07071
248 5HJM MTA 7.14286
249 3C6K MTA 7.14286
250 3C6K SPD 7.14286
251 3K5I ADP 7.19603
252 3Q87 SAM 7.2
253 4II2 ATP 7.22892
254 1ODJ GMP 7.23404
255 2ZFU SAH 7.44186
256 1MO9 KPC 7.45698
257 1MO9 FAD 7.45698
258 5E72 SAM 7.51445
259 2BJ4 OHT 7.53968
260 4RJD TFP 7.57576
261 1E1M NAP 7.6087
262 1E1M FAD 7.6087
263 5JE0 AZ8 7.69231
264 5JE0 SAH 7.69231
265 5ZQ4 AMP 7.69231
266 1XHC FAD 7.71429
267 4XFR CIT 7.72834
268 2UYQ SAM 7.74194
269 5YX4 HCC 7.75862
270 1GEG NAD 7.8125
271 1ZGA SAH 7.84314
272 6C5B SAH 7.91789
273 1VE3 SAM 7.92952
274 5JGL SAM 7.95848
275 1I1N SAH 7.9646
276 4KRG SAH 8
277 6ECU SAH 8.22785
278 6ECW SAH 8.25397
279 5DYO FLU 8.25688
280 4D04 FAD 8.28571
281 4D04 NAP 8.28571
282 3PFG SAM 8.36502
283 3PFG TLO 8.36502
284 2HNK SAH 8.3682
285 3RKR NAP 8.39695
286 5UFN SAH 8.40336
287 4B3J COA 8.43672
288 4POO SAM 8.5
289 5MPT SAH 8.57143
290 1KO8 6PG 8.57143
291 3KLJ FAD 8.57143
292 4BLW SAH 8.65052
293 4BLW AMP 8.65052
294 2Q46 NAP 8.69565
295 5BSZ SAH 8.8
296 4R6W PC 8.91473
297 4R6W SAH 8.91473
298 2YX1 SFG 8.92857
299 1XCL SAH 8.93617
300 5FTW SAH 8.98438
301 2BZG SAH 9.05172
302 3VYW SAM 9.09091
303 1XDS SAM 9.14286
304 1QZZ SAM 9.14286
305 4YMH SAH 9.16667
306 3IA4 MTX 9.25926
307 1Q0S SAH 9.26641
308 2PWY SAH 9.30233
309 4OBW SAM 9.33852
310 3MCT SAH 9.42761
311 1UAY ADN 9.50413
312 2FR6 URI 9.58904
313 2FR6 CTN 9.58904
314 5W7M SAH 9.61539
315 3DXY SAM 9.63303
316 5ICE SAH 9.65909
317 5ICE 2H4 9.65909
318 5JCM FAD 9.71429
319 5JCM NAD 9.71429
320 5JCM ISD 9.71429
321 2HMT NAI 9.72222
322 6BQ6 TER 9.96979
323 4V3C C 10.0515
324 1UZN NAP 10.1215
325 5CHR 4NC 10.219
326 3G2O SAM 10.3679
327 1X14 NAD 10.4738
328 5AN1 GSH 10.5023
329 1FP2 SAH 10.5114
330 1FP2 HMO 10.5114
331 1P1C SAH 10.5528
332 3T7S SAM 10.8209
333 4D7E FAD 10.8571
334 3BXO SAM 10.8787
335 5K7U SAM 10.8883
336 1QAN SAH 11.0656
337 5ZJ5 NAI 11.1111
338 2CDU ADP 11.1429
339 2PXX SAH 11.1628
340 3QOX SAH 11.2676
341 3A25 SAM 11.2957
342 3L9W AMP 11.4286
343 3L9W GSH 11.4286
344 3H8V ATP 11.6438
345 5DNK SAH 12
346 5IL1 SAM 12
347 5L95 AMP 12.1864
348 3U4C NDP 12.2857
349 2HIM ASP 12.2905
350 4CQM NAP 12.2951
351 3P2E SAH 12.4444
352 3NUG NAD 12.5506
353 3WV8 ATP 12.844
354 2YVJ NAI 12.844
355 1KPG SAH 12.892
356 1ELI PYC 13.1105
357 3KIF GDL 13.2075
358 4KXQ APR 13.3333
359 1R18 SAH 13.6564
360 1TPY SAH 13.9373
361 1KPH SAH 13.9373
362 6DUB SAH 13.964
363 2QA1 FAD 14
364 1Y8Q ATP 14.1618
365 5MW4 5JU 14.3713
366 4YUW 4JU 14.4737
367 4YUW S4M 14.4737
368 3P9C SAH 14.5714
369 6F5Z SAH 14.7541
370 3VZS NAP 14.786
371 3HVJ 705 14.9321
372 5N5D SAM 15.0442
373 3QXV MTX 15.0794
374 4PNE SAH 15.894
375 2BOS GLA GAL GLC 16.1765
376 2BOS GLA GAL GLC NBU 16.1765
377 1W6U NAP 16.2252
378 1W8D NAP 16.2252
379 1W73 NAP 16.2252
380 3A27 SAM 16.5441
381 3AD8 NAD 17.1717
382 3MB5 SAM 17.2549
383 6FS0 E4W 18.239
384 5ZCO CHD 19.1781
385 5W97 CHD 19.1781
386 5Z84 CHD 19.1781
387 5DXA SFG 19.7708
388 5DX0 SFG 19.7708
389 5DWQ SFG 19.7708
390 5DX1 SFG 19.7708
391 6ARJ BW4 19.7708
392 6ARJ SAH 19.7708
393 5DX8 SFG 19.7708
394 1G60 SAM 20
395 5G3L SIA 20.202
396 1L3I SAH 20.3125
397 4LWP SAH 20.9239
398 2Y69 CHD 23.75
399 5FWA J7C 23.991
400 4XUC SAM 27.9817
401 4XUC 43G 27.9817
402 5E8J SAH 29.5455
403 5FUB SAH 29.6736
404 1F3L SAH 36.1371
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