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Receptor
PDB id Resolution Class Description Source Keywords
4XC0 1.77 Å NON-ENZYME: OTHER N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN WITH ACP DICTYOSTELIUM DISCOIDEUM HSP90 ACP CHAPERONE
Ref.: FIRST STRUCTURAL VIEW OF A PEPTIDE INTERACTING WITH NUCLEOTIDE BINDING DOMAIN OF HEAT SHOCK PROTEIN 90 SCI REP V. 5 17015 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACP A:301;
Valid;
none;
submit data
505.208 C11 H18 N5 O12 P3 c1nc(...
MG A:302;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
PEG A:303;
Invalid;
none;
submit data
106.12 C4 H10 O3 C(COC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4XCL 1.21 Å NON-ENZYME: OTHER N-TERMINAL DOMAIN OF HSP90 FROM DICTYOSTELIUM DISCOIDEUM IN WITH AGS DICTYOSTELIUM DISCOIDEUM HSP90 AGS CHAPERONE
Ref.: FIRST STRUCTURAL VIEW OF A PEPTIDE INTERACTING WITH NUCLEOTIDE BINDING DOMAIN OF HEAT SHOCK PROTEIN 90 SCI REP V. 5 17015 2015
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 4XDM - GDM C29 H40 N2 O9 C[C@H]1C[C....
2 4XC0 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
3 4XCJ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
4 4XCL - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
5 4XD8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
70% Homology Family (252)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6GQU - CMP C10 H12 N5 O6 P c1nc(c2c(n....
2 1UY7 ic50 > 200 uM PU4 C17 H21 N5 O CCCCn1c(nc....
3 3B24 Kd = 0.042 mM B2J C6 H10 N4 S CCSc1nc(nc....
4 3EKR Ki = 2.8 uM PY9 C18 H19 N O3 Cc1ccccc1[....
5 5J9X Kd = 0.00000145 M 6GC C20 H21 F N4 O4 CCCCN(C)C(....
6 3R4N Ki = 0.13 uM FU5 C15 H15 Cl F3 N3 O Cc1cc(nc(n....
7 2YEG - XQG C6 H6 N4 S CSc1c2c([n....
8 3OWD - MEY C24 H18 Cl N3 O5 S c1ccc2c(c1....
9 5LNY Kd = 42 nM 70K C25 H29 N5 O4 CN(c1ccc(c....
10 3BMY ic50 = 0.03 uM CXZ C19 H20 Cl N3 O4 c1cc2c(cc1....
11 3VHD Kd = 0.52 nM VHE C19 H23 N5 O2 S Cc1cc(c2cc....
12 2XJJ Kd = 0.31 uM L81 C19 H20 N2 O2 CC1(CNc2c1....
13 2YE3 - VXX C9 H10 O4 COc1cc(ccc....
14 6GPH - A12 C11 H17 N5 O9 P2 c1nc(c2c(n....
15 6EL5 Kd = 0.133 uM PU1 C20 H21 Cl F N5 O3 COc1cc(c(c....
16 1UY8 ic50 = 75 uM PU5 C17 H21 N5 O CCCCn1c(nc....
17 3T10 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
18 4CWR Ki = 0.005 uM HAJ C17 H12 F N5 O2 c1cc2c(c(c....
19 3EKO Ki = 0.2 uM PYU C11 H9 N O4 c1ccn(c1)C....
20 4XIP Ki = 235 nM 40W C18 H20 N2 O2 Cc1cn(c2c1....
21 1UYE ic50 > 200 uM PU9 C20 H22 Cl N5 O3 COc1cc(c(c....
22 4O07 Ki = 0.042 uM FGH C27 H35 N3 O2 CC(C)Cc1cc....
23 2JJC - LGA C4 H5 N3 c1cnc(nc1)....
24 2YI5 Kd = 39 nM YI5 C16 H13 Cl N2 O4 S COc1ccc(cc....
25 1UY9 ic50 = 15.3 uM PU6 C17 H19 N5 O2 CCCCn1c(nc....
26 6EI5 Kd = 3.83 nM B5Q C25 H23 N5 O CNCc1ccccc....
27 3OWB - BSM C19 H18 Cl N3 O4 CCNC(=O)c1....
28 2YKB - YKB C23 H19 N5 O2 c1ccc2c(c1....
29 2QG2 Ki = 4 uM A91 C17 H15 N5 O2 Cc1cc(nc(n....
30 4B7P Kd = 0.346 nM 9UN C22 H22 N4 O7 CN1CCC(CC1....
31 4EFT ic50 = 85 uM EFT C16 H19 N3 O c1cc2c(cc1....
32 2WI6 ic50 = 0.23 uM ZZ6 C15 H12 Cl2 N4 O S CCNC(=O)c1....
33 2YEH - 2KU C9 H13 N5 O COCCCNc1c2....
34 6GR5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
35 4L94 - S46 C12 H16 N2 O2 CN1CCN(CC1....
36 6GPP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
37 2YKE - YKE C29 H19 N5 O c1cc(c2ccc....
38 4O04 Ki = 0.69 uM 2Q8 C21 H25 N3 O2 CC1(Cc2c(c....
39 2YE5 - 2A7 C7 H8 O3 COc1cc(cc(....
40 3FT5 ic50 = 15 uM MO8 C8 H11 N3 S Cc1c2c(nc(....
41 2XDU - LGA C4 H5 N3 c1cnc(nc1)....
42 2YEB - 2K4 C7 H6 N2 O c1cc2cn[nH....
43 3B26 Kd = 0.23 uM B2L C17 H15 N3 O Cc1cc(nc(n....
44 4XIQ Ki = 86 nM 40Y C20 H22 N2 O3 Cc1c2n(c3c....
45 3T0Z - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
46 6GQS - A12 C11 H17 N5 O9 P2 c1nc(c2c(n....
47 4L8Z ic50 = 18.7 uM RL1 C22 H17 Br N4 O3 c1ccc2c(c1....
48 2YK9 - YK9 C19 H11 N3 O c1ccc2c(c1....
49 6EYA Kd = 33 nM C4K C24 H21 N3 O4 Cc1cccc(c1....
50 5M4H - 7FX C14 H12 F3 N3 O3 c1cc(c(cc1....
51 4AWQ ic50 = 479 nM 592 C29 H32 N4 O3 Cc1c(cccc1....
52 2VCJ ic50 = 0.021 uM 2EQ C23 H24 Cl N3 O5 CCNC(=O)c1....
53 3RLR Ki = 0.03 uM 3RR C16 H12 Cl2 N4 O Cc1c(c2c(n....
54 2XDX Kd = 0.35 uM WOE C11 H10 Cl N3 O COc1ccccc1....
55 6ELO Kd = 0.514 uM BAW C18 H17 F N2 O2 CCc1cc(c(c....
56 3HEK Ki = 3.5 nM BD0 C22 H24 Cl F2 N2 O3 c1cc(ccc1C....
57 2XHT Kd = 1.1 uM C0Y C15 H21 N O3 CC(C)(C)c1....
58 2YEE - 2EC C7 H9 N5 CCn1cnc2c1....
59 3K98 Ki < 1 nM 1RC C18 H17 Cl N2 O4 CCNC(=O)[C....
60 3INX ic50 = 0.022 uM JZC C24 H30 N2 O6 c1c(cc(c2c....
61 2WI3 ic50 = 350 uM ZZ3 C5 H8 N4 S Cc1nc(nc(n....
62 3B27 Kd = 6.9 uM B2T C10 H9 Cl N4 S CSc1nc(nc(....
63 4BQG - 50Q C12 H8 Cl2 O3 c1cc(c(cc1....
64 1UYD ic50 > 200 uM PU8 C19 H24 Cl N5 O3 CCCCn1c(nc....
65 2FWZ ic50 = 50 nM H71 C18 H21 I N6 O2 S CC(C)NCCCn....
66 2BYI ic50 = 0.461 uM 2DD C17 H15 Cl N4 O5 S c1cc(ccc1C....
67 4XIT Ki = 41 nM 40Z C25 H26 Cl N3 O3 Cc1c2n(c3c....
68 3VHA Kd = 40 nM VHA C21 H21 N3 O2 S Cc1ccc2cc1....
69 5J8U Kd = 0.00000145 M 6DL C14 H9 Br F N3 O3 c1ccc(c(c1....
70 5J6N - 6FF C18 H19 F N4 O5 S CCCN(C)S(=....
71 5FNC Kd = 77 uM IEE C12 H13 Cl N4 Cc1ccc(cc1....
72 5J6M Kd = 0.00000145 M 6FJ C21 H17 F N4 O5 CN(Cc1ccco....
73 1UYG ic50 = 53.5 uM PU2 C14 H14 F N5 O2 COc1ccc(c(....
74 3D0B Kd = 0.29 uM SNX C22 H23 N3 O3 COCCNc1cc(....
75 2WI4 ic50 = 1.56 uM ZZ4 C16 H11 Cl2 N5 c1ccc(cc1)....
76 2YEJ - XQK C9 H9 N3 O3 Cc1c(c([nH....
77 4AWO ic50 = 24 nM 99B C29 H37 N5 O3 CC[C@@H](C....
78 1UYI ic50 = 4.1 uM PUZ C19 H20 F N5 O2 COc1ccc(c(....
79 1BYQ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
80 1UY6 ic50 > 200 uM PU3 C19 H25 N5 O3 CCCCn1c(nc....
81 4CWF Ki = 32.4 uM H05 C12 H13 N5 CCCc1nc2cc....
82 4W7T ic50 = 0.9 uM 3JC C15 H15 N3 O Cc1c2c(nc(....
83 2XJX Kd = 0.71 nM XJX C24 H31 N3 O3 CC(C)c1cc(....
84 4AWP ic50 = 81 nM 99A C30 H33 N5 O3 Cc1cc(c(cc....
85 2XJG Kd = 0.015 uM XJG C19 H21 N O3 CC(C)c1cc(....
86 4CWT Ki = 0.179 uM IK9 C19 H17 F N6 O3 c1cc2c(cc1....
87 4O09 Ki = 0.02 uM 2R6 C24 H30 N2 O2 Cc1cn(c2c1....
88 2BT0 ic50 = 5.7 uM CT5 C20 H20 N2 O4 CCc1cc(c(c....
89 2QG0 Ki = 1.9 uM A94 C17 H19 N5 O4 S Cc1cc(nc(n....
90 2XK2 Kd = 10 uM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3R91 ic50 = 0.092 uM 06H C25 H32 N4 O3 Cc1c2n(c3c....
92 2CCS ic50 = 2 uM 4BH C13 H15 Cl N4 O2 c1c(c(cc(c....
93 2YKJ - YKJ C25 H18 N6 O c1ccc2c(c1....
94 6GPY - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
95 5OCI Kd = 9 nM 9R8 C27 H28 N4 O3 Cc1cccc(c1....
96 4FCP - 42C C7 H9 N5 CN(C)c1c2c....
97 5J2X Kd = 0.00000145 M 6DL C14 H9 Br F N3 O3 c1ccc(c(c1....
98 3WHA Kd = 0.48 nM WHA C19 H18 Cl N5 O2 S c1cc2c3c(c....
99 6GR3 - AN2 C10 H16 N6 O9 P2 c1nc(c2c(n....
100 6EY8 Kd = 1.55 uM C4T C23 H20 Cl N3 O2 CN(Cc1ccc(....
101 2YEA - 2A9 C8 H10 O3 COc1ccc(cc....
102 2YI7 Kd = 4.8 nM BZ8 C16 H13 Cl N2 O3 S CCOc1ccc(c....
103 2YE2 - XQI C9 H10 O4 COC(=O)Cc1....
104 6F1N Kd = 0.547 uM C8W C20 H19 N5 O5 S COc1ccc(cc....
105 4CWO Ki = 6.1 uM T62 C16 H13 N5 O2 c1ccc2c(c1....
106 5J8M Kd = 0.00000145 M 6DL C14 H9 Br F N3 O3 c1ccc(c(c1....
107 4U93 ic50 = 0.013 uM 990 C20 H18 F N5 O2 Cc1c2c(nc(....
108 4CWS Ki = 0.012 uM G3R C19 H18 N6 O3 c1cc2c(cc1....
109 2BYH ic50 = 0.258 uM 2D7 C18 H14 Cl N3 O4 CC(=O)c1cc....
110 4EGI ic50 = 150 uM B2J C6 H10 N4 S CCSc1nc(nc....
111 1OSF - KOS C32 H48 N4 O8 C[C@H]1C[C....
112 3K97 Ki = 10 nM 4CD C18 H18 Cl N O3 Cc1ccccc1[....
113 2YED - ADE C5 H5 N5 c1[nH]c2c(....
114 6CEO - D57 C22 H22 N2 O6 COC(=O)c1c....
115 2YKC - YKC C25 H17 N5 O c1ccc2c(c1....
116 6GPT - A12 C11 H17 N5 O9 P2 c1nc(c2c(n....
117 5VYY Kd = 0.62 uM 9QY C20 H19 Cl N2 O4 COC(=O)c1c....
118 2WI2 ic50 = 350 uM ZZ3 C5 H8 N4 S Cc1nc(nc(n....
119 6GPF - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
120 2YE7 - 2GA C8 H10 N4 S3 Cc1c(c(n[n....
121 1UYF ic50 = 30 uM PU1 C20 H21 Cl F N5 O3 COc1cc(c(c....
122 3VHC Kd = 1.3 nM VHC C22 H22 N4 O2 S Cc1cc(c2cc....
123 2YK2 - YJX C18 H14 N4 O c1ccc2c(c1....
124 5J64 Kd = 0.00000145 M 6G7 C14 H10 F N3 O3 c1ccc(c(c1....
125 2XHR Kd = 0.0048 uM C0P C16 H17 Cl3 N4 O2 c1c(c(cc(c....
126 3R92 ic50 = 0.883 uM 06J C26 H34 N4 O2 Cc1c2n(c3c....
127 2CCT ic50 = 6.3 uM 2E1 C16 H20 Cl N5 O3 CCNC(=O)c1....
128 4XIR Ki = 115 nM 40X C23 H27 Cl N2 O3 CCC[C@H]1C....
129 4CWN Ki = 2.6 uM 6LV C18 H17 N5 O2 COc1cc(cc(....
130 1YET - GDM C29 H40 N2 O9 C[C@H]1C[C....
131 3QDD ic50 = 5.1 nM 94M C14 H15 Cl N6 O Cc1cnc(c(c....
132 6GPO - CMP C10 H12 N5 O6 P c1nc(c2c(n....
133 2H55 - DZ8 C19 H22 F I N6 O2 CC(C)NCCCn....
134 1UYK ic50 = 17.1 uM PUX C17 H18 F N5 O2 CCCCn1c(nc....
135 2XDS - MT0 C9 H7 Cl N2 Cc1c2ccccc....
136 2WI1 ic50 > 4000 uM ZZ2 C8 H13 N3 O2 Cc1cc(nc(n....
137 4FCR Kd = 0.4 nM 0TM C19 H18 Cl N5 O3 S CN(C)C(=O)....
138 5FNF Kd = 700 uM TQL C12 H10 N2 O3 c1cc(cnc1)....
139 5J27 Kd = 0.00000145 M 6FF C18 H19 F N4 O5 S CCCN(C)S(=....
140 2YEC - XQ0 C8 H8 N2 O Cc1c2ccc(c....
141 4CWQ Ki = 0.088 uM W2D C17 H14 N6 O4 S c1cc2c(cc1....
142 2YE4 - 2FY C9 H10 O3 CCC(=O)c1c....
143 2BSM ic50 = 1.5 uM BSM C19 H18 Cl N3 O4 CCNC(=O)c1....
144 2YKI Kd = 0.35 nM YKI C27 H18 N6 O c1ccc2c(c1....
145 3RLQ Ki = 0.04 uM 3RQ C15 H10 Cl2 N4 O Cc1nc(c2c(....
146 3MNR - SD1 C27 H31 N3 O5 Cc1cc2c(n1....
147 3K99 Ki = 60 nM PFT C15 H13 N O3 c1ccc2c(c1....
148 5LNZ - 70Z C25 H31 N5 O4 CCCCN(C)C(....
149 5J20 Kd = 0.00000145 M 6FJ C21 H17 F N4 O5 CN(Cc1ccco....
150 6GQR - APC C11 H18 N5 O12 P3 c1nc(c2c(n....
151 2YEF - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
152 3B28 Kd = 0.0034 uM B2X C16 H13 Cl N4 O S CSc1nc(nc(....
153 3R4P Ki = 0.011 uM FU7 C21 H21 Cl2 F2 N7 O2 CC(CNC(=O)....
154 4NH8 Ki = 3 nM 2LC C22 H26 F N3 O3 Cc1cn(c2c1....
155 6ELN Kd = 0.9 uM P4A C17 H16 N2 O3 Cc1c(c(n[n....
156 2XDK Kd = 250 uM XDK C9 H8 N4 c1cc(cnc1)....
157 2VCI ic50 = 0.021 uM 2GJ C26 H31 N3 O5 CCNC(=O)c1....
158 5M4E - 7F9 C18 H20 N2 O5 CCNC(=O)CN....
159 3QTF ic50 = 0.11 uM 05S C24 H32 N4 O2 Cc1c2n(c3c....
160 6EYB Kd = 4.22 uM C3Z C23 H18 N4 O c1ccc(cc1)....
161 2WI5 ic50 = 0.9 uM ZZ5 C17 H15 N5 O2 S CCOc1ccc(c....
162 2XAB Kd = 0.54 nM VHD C18 H19 N O3 CC(C)c1cc(....
163 2UWD Kd = 4.5 nM 2GG C19 H17 Cl N2 O5 CCNC(=O)c1....
164 1UYH ic50 = 14.3 uM PU0 C18 H22 F N5 O2 CCCCn1c(nc....
165 6GP8 - APC C11 H18 N5 O12 P3 c1nc(c2c(n....
166 2XDL Kd = 790 uM 2DL C12 H17 N O3 CCN(CC)C(=....
167 5J82 Kd = 0.00000145 M 6GV C18 H19 F N4 O5 S CC(C)N(C)S....
168 4L91 - X29 C12 H7 Br Cl N3 O2 c1cc2nnc(n....
169 6GR1 - APC C11 H18 N5 O12 P3 c1nc(c2c(n....
170 6GQ6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
171 3RKZ ic50 = 0.083 uM 06T C28 H39 N5 O3 Cc1c2n(c3c....
172 5LO0 - 70N C28 H26 F2 N6 O3 S CN1CCN(CC1....
173 4EEH ic50 = 45 uM HH6 C13 H10 N2 O2 c1cc(ccc1c....
174 2YE8 - 2D3 C9 H9 N3 O3 Cc1c(c(n[n....
175 2YI6 - 6QM C18 H18 N2 O3 S CCc1cc(c(c....
176 2YJX - YJX C18 H14 N4 O c1ccc2c(c1....
177 4CWP Ki = 0.17 uM TV2 C17 H13 N5 O2 c1ccc2c(c1....
178 4NH7 Ki = 4 nM HIE C23 H27 F3 N4 O3 CC1(Cc2c(c....
179 6EY9 Kd = 1.24 uM C4N C24 H22 Cl N3 O2 Cc1cccc(c1....
180 4EFU ic50 = 0.25 uM EFU C24 H23 N3 O2 Cc1cccc(c1....
181 5NYH Kd = 18.7 nM 9EK C24 H27 N5 O4 CN(c1ccc(c....
182 2YJW - YJW C16 H13 N O3 Cc1c(c(no1....
183 4O05 Ki = 0.037 uM 2Q9 C26 H34 N4 O2 CC(C)Nc1cc....
184 3B25 Kd = 0.86 uM B2K C12 H13 N3 O2 S Cc1ccc(cc1....
185 3OW6 - MEX C13 H10 N2 O3 c1ccc2c(c1....
186 3FT8 ic50 = 0.03 uM MOJ C20 H18 F N5 O Cc1c2c(nc(....
187 4EGH ic50 = 550 uM 0OY C11 H13 N O3 c1cc(ccc1C....
188 5ZR3 ic50 = 98 nM 9J0 C24 H24 N8 O Cc1cc(ccc1....
189 3INW ic50 = 0.039 uM JZB C24 H29 Cl N2 O6 c1c(c2c(c(....
190 3HHU ic50 = 41 nM 819 C21 H24 N4 O4 S CCOC(=O)NC....
191 6GPR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
192 4BQJ - XKL C18 H15 N3 O7 CCNC(=O)c1....
193 4O0B Ki = 0.005 uM 2QA C25 H30 N2 O2 Cc1cn(c2c1....
194 4JQL ic50 = 1 uM VJ6 C28 H41 N3 O9 C[C@H]1/C=....
195 1UYC ic50 = 41 uM PU7 C18 H23 N5 O2 CCCCn1c(nc....
196 2YE9 - 2D4 C20 H15 N O4 S2 c1ccc2c(c1....
197 2FWY ic50 = 200 nM H64 C18 H21 Br N6 O2 S CC(C)NCCCn....
198 3R4M Ki = 1.2 uM WOE C11 H10 Cl N3 O COc1ccccc1....
199 6ELP Kd = 0.236 uM BA8 C22 H18 Cl N3 O2 c1ccc(c(c1....
200 5J86 Kd = 0.00000145 M 6GW C22 H20 N4 O4 S Cc1ccccc1N....
201 4EGK ic50 = 40 nM RDC C18 H17 Cl O6 C[C@@H]1C[....
202 5FND Kd = 320 uM IQ5 C10 H11 N3 O S Cc1cc2c(cc....
203 3BM9 ic50 = 0.19 uM BXZ C13 H8 Br N O4 c1cc2c(cc1....
204 4FCQ Kd = 0.156 uM 2N6 C16 H14 N4 S Cc1ccc(c(c....
205 5GGZ ic50 = 0.056 uM 6TN C19 H23 N3 O4 CCOc1ncc2c....
206 2YI0 Kd = 7.5 nM YI0 C15 H11 Cl N2 O3 S COc1ccc(cc....
207 2QFO Ki = 18 uM A13 C6 H6 F3 N3 Cc1cc(nc(n....
208 2WI7 ic50 = 0.058 uM 2KL C21 H23 Cl2 N5 O2 S CCNC(=O)c1....
209 2YEI - XQK C9 H9 N3 O3 Cc1c(c([nH....
210 5J6L Kd = 0.00000145 M 6GC C20 H21 F N4 O4 CCCCN(C)C(....
211 5ODX Kd = 195 nM 9RZ C26 H31 N5 O5 CN(c1ccc(c....
212 3RLP Kd = 0.084 uM 3RP C12 H11 Cl2 N3 O Cc1cc(nc(n....
213 2IOR - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
214 4XDM - GDM C29 H40 N2 O9 C[C@H]1C[C....
215 4XC0 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
216 4XCJ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
217 4XCL - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
218 4XD8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
219 2BRC ic50 = 7.1 uM CT5 C20 H20 N2 O4 CCc1cc(c(c....
220 4CE3 - L4V C18 H22 Cl N O4 CN1CCC/C=C....
221 2VW5 Ki = 3 nM BC6 C28 H42 N2 O6 C[C@H]1CCC....
222 4ASA - 59C C32 H45 N3 O8 C[C@H]1C[C....
223 1BGQ Kd = 2.7 nM RDC C18 H17 Cl O6 C[C@@H]1C[....
224 2XX2 - 13C C17 H20 Cl N O4 c1c(c2c(c(....
225 2WEP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
226 2WER Kd = 90 nM RDC C18 H17 Cl O6 C[C@@H]1C[....
227 2YGA Kd = 24.5 uM GDM C29 H40 N2 O9 C[C@H]1C[C....
228 2FXS Kd = 0.52 uM RDA C18 H18 Cl N O8 COc1cc(c(c....
229 2XX4 - 13I C20 H26 Cl N O6 CCO[C@H]([....
230 1AM1 Kd = 132 mM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
231 2XD6 ic50 = 0.011 uM XD6 C18 H19 Cl O6 c1c(c2c(c(....
232 2CGF Kd = 0.39 uM P2N C17 H19 Cl O5 c1c(c2c(c(....
233 1AMW Kd = 29 uM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
234 4ASG - 814 C35 H44 N2 O9 C[C@H]1C[C....
235 1A4H - GDM C29 H40 N2 O9 C[C@H]1C[C....
236 4CE2 - BO5 C19 H24 Cl N O4 CN1CC/C=C/....
237 2BRE ic50 < 1 uM KJ2 C18 H18 Cl N3 O3 c1cc(ccc1c....
238 2IWX Kd = 0.21 uM M1S C18 H21 Cl O5 c1c(c2c(c(....
239 2XX5 - 13N C25 H27 Cl N2 O5 c1ccc(cc1)....
240 2YGF Kd = 12 uM GDM C29 H40 N2 O9 C[C@H]1C[C....
241 2VWC Ki = 0.24 uM BC2 C30 H42 N2 O8 C[C@H]1C[C....
242 4CE1 - 7FK C20 H26 Cl N O4 CN1CC/C=C/....
243 2WEQ Kd = 1.27 uM GDM C29 H40 N2 O9 C[C@H]1C[C....
244 2YGE Kd = 24.5 uM GDM C29 H40 N2 O9 C[C@H]1C[C....
245 3NMQ - 7PP C21 H24 Cl N5 O2 Cc1cnc(c(c....
246 5UCJ Kd = 0.44 uM KU3 C19 H17 F N2 O3 CC(C)c1cc(....
247 1UYM - PU3 C19 H25 N5 O3 CCCCn1c(nc....
248 5UC4 Kd = 0.35 uM 83S C19 H19 N O3 CC(C)c1cc(....
249 3K60 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
250 1YC3 Kd = 0.68 uM 4BC C19 H16 N2 O6 CCc1cc(c(c....
251 1YC4 Kd = 0.28 uM 43P C14 H14 N4 O2 CCc1cc(c(c....
252 1YC1 Kd = 0.68 uM 4BC C19 H16 N2 O6 CCc1cc(c(c....
50% Homology Family (265)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6GQU - CMP C10 H12 N5 O6 P c1nc(c2c(n....
2 1UY7 ic50 > 200 uM PU4 C17 H21 N5 O CCCCn1c(nc....
3 3B24 Kd = 0.042 mM B2J C6 H10 N4 S CCSc1nc(nc....
4 3EKR Ki = 2.8 uM PY9 C18 H19 N O3 Cc1ccccc1[....
5 5J9X Kd = 0.00000145 M 6GC C20 H21 F N4 O4 CCCCN(C)C(....
6 3R4N Ki = 0.13 uM FU5 C15 H15 Cl F3 N3 O Cc1cc(nc(n....
7 2YEG - XQG C6 H6 N4 S CSc1c2c([n....
8 3OWD - MEY C24 H18 Cl N3 O5 S c1ccc2c(c1....
9 5LNY Kd = 42 nM 70K C25 H29 N5 O4 CN(c1ccc(c....
10 3BMY ic50 = 0.03 uM CXZ C19 H20 Cl N3 O4 c1cc2c(cc1....
11 3VHD Kd = 0.52 nM VHE C19 H23 N5 O2 S Cc1cc(c2cc....
12 2XJJ Kd = 0.31 uM L81 C19 H20 N2 O2 CC1(CNc2c1....
13 2YE3 - VXX C9 H10 O4 COc1cc(ccc....
14 6GPH - A12 C11 H17 N5 O9 P2 c1nc(c2c(n....
15 6EL5 Kd = 0.133 uM PU1 C20 H21 Cl F N5 O3 COc1cc(c(c....
16 1UY8 ic50 = 75 uM PU5 C17 H21 N5 O CCCCn1c(nc....
17 3T10 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
18 4CWR Ki = 0.005 uM HAJ C17 H12 F N5 O2 c1cc2c(c(c....
19 3EKO Ki = 0.2 uM PYU C11 H9 N O4 c1ccn(c1)C....
20 4XIP Ki = 235 nM 40W C18 H20 N2 O2 Cc1cn(c2c1....
21 1UYE ic50 > 200 uM PU9 C20 H22 Cl N5 O3 COc1cc(c(c....
22 4O07 Ki = 0.042 uM FGH C27 H35 N3 O2 CC(C)Cc1cc....
23 2JJC - LGA C4 H5 N3 c1cnc(nc1)....
24 2YI5 Kd = 39 nM YI5 C16 H13 Cl N2 O4 S COc1ccc(cc....
25 1UY9 ic50 = 15.3 uM PU6 C17 H19 N5 O2 CCCCn1c(nc....
26 6EI5 Kd = 3.83 nM B5Q C25 H23 N5 O CNCc1ccccc....
27 3OWB - BSM C19 H18 Cl N3 O4 CCNC(=O)c1....
28 2YKB - YKB C23 H19 N5 O2 c1ccc2c(c1....
29 2QG2 Ki = 4 uM A91 C17 H15 N5 O2 Cc1cc(nc(n....
30 4B7P Kd = 0.346 nM 9UN C22 H22 N4 O7 CN1CCC(CC1....
31 4EFT ic50 = 85 uM EFT C16 H19 N3 O c1cc2c(cc1....
32 2WI6 ic50 = 0.23 uM ZZ6 C15 H12 Cl2 N4 O S CCNC(=O)c1....
33 2YEH - 2KU C9 H13 N5 O COCCCNc1c2....
34 6GR5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
35 4L94 - S46 C12 H16 N2 O2 CN1CCN(CC1....
36 6GPP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
37 2YKE - YKE C29 H19 N5 O c1cc(c2ccc....
38 4O04 Ki = 0.69 uM 2Q8 C21 H25 N3 O2 CC1(Cc2c(c....
39 2YE5 - 2A7 C7 H8 O3 COc1cc(cc(....
40 3FT5 ic50 = 15 uM MO8 C8 H11 N3 S Cc1c2c(nc(....
41 2XDU - LGA C4 H5 N3 c1cnc(nc1)....
42 2YEB - 2K4 C7 H6 N2 O c1cc2cn[nH....
43 3B26 Kd = 0.23 uM B2L C17 H15 N3 O Cc1cc(nc(n....
44 4XIQ Ki = 86 nM 40Y C20 H22 N2 O3 Cc1c2n(c3c....
45 3T0Z - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
46 6GQS - A12 C11 H17 N5 O9 P2 c1nc(c2c(n....
47 4L8Z ic50 = 18.7 uM RL1 C22 H17 Br N4 O3 c1ccc2c(c1....
48 2YK9 - YK9 C19 H11 N3 O c1ccc2c(c1....
49 6EYA Kd = 33 nM C4K C24 H21 N3 O4 Cc1cccc(c1....
50 5M4H - 7FX C14 H12 F3 N3 O3 c1cc(c(cc1....
51 4AWQ ic50 = 479 nM 592 C29 H32 N4 O3 Cc1c(cccc1....
52 2VCJ ic50 = 0.021 uM 2EQ C23 H24 Cl N3 O5 CCNC(=O)c1....
53 3RLR Ki = 0.03 uM 3RR C16 H12 Cl2 N4 O Cc1c(c2c(n....
54 2XDX Kd = 0.35 uM WOE C11 H10 Cl N3 O COc1ccccc1....
55 6ELO Kd = 0.514 uM BAW C18 H17 F N2 O2 CCc1cc(c(c....
56 3HEK Ki = 3.5 nM BD0 C22 H24 Cl F2 N2 O3 c1cc(ccc1C....
57 2XHT Kd = 1.1 uM C0Y C15 H21 N O3 CC(C)(C)c1....
58 2YEE - 2EC C7 H9 N5 CCn1cnc2c1....
59 3K98 Ki < 1 nM 1RC C18 H17 Cl N2 O4 CCNC(=O)[C....
60 3INX ic50 = 0.022 uM JZC C24 H30 N2 O6 c1c(cc(c2c....
61 2WI3 ic50 = 350 uM ZZ3 C5 H8 N4 S Cc1nc(nc(n....
62 3B27 Kd = 6.9 uM B2T C10 H9 Cl N4 S CSc1nc(nc(....
63 4BQG - 50Q C12 H8 Cl2 O3 c1cc(c(cc1....
64 1UYD ic50 > 200 uM PU8 C19 H24 Cl N5 O3 CCCCn1c(nc....
65 2FWZ ic50 = 50 nM H71 C18 H21 I N6 O2 S CC(C)NCCCn....
66 2BYI ic50 = 0.461 uM 2DD C17 H15 Cl N4 O5 S c1cc(ccc1C....
67 4XIT Ki = 41 nM 40Z C25 H26 Cl N3 O3 Cc1c2n(c3c....
68 3VHA Kd = 40 nM VHA C21 H21 N3 O2 S Cc1ccc2cc1....
69 5J8U Kd = 0.00000145 M 6DL C14 H9 Br F N3 O3 c1ccc(c(c1....
70 5J6N - 6FF C18 H19 F N4 O5 S CCCN(C)S(=....
71 5FNC Kd = 77 uM IEE C12 H13 Cl N4 Cc1ccc(cc1....
72 5J6M Kd = 0.00000145 M 6FJ C21 H17 F N4 O5 CN(Cc1ccco....
73 1UYG ic50 = 53.5 uM PU2 C14 H14 F N5 O2 COc1ccc(c(....
74 3D0B Kd = 0.29 uM SNX C22 H23 N3 O3 COCCNc1cc(....
75 2WI4 ic50 = 1.56 uM ZZ4 C16 H11 Cl2 N5 c1ccc(cc1)....
76 2YEJ - XQK C9 H9 N3 O3 Cc1c(c([nH....
77 4AWO ic50 = 24 nM 99B C29 H37 N5 O3 CC[C@@H](C....
78 1UYI ic50 = 4.1 uM PUZ C19 H20 F N5 O2 COc1ccc(c(....
79 1BYQ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
80 1UY6 ic50 > 200 uM PU3 C19 H25 N5 O3 CCCCn1c(nc....
81 4CWF Ki = 32.4 uM H05 C12 H13 N5 CCCc1nc2cc....
82 4W7T ic50 = 0.9 uM 3JC C15 H15 N3 O Cc1c2c(nc(....
83 2XJX Kd = 0.71 nM XJX C24 H31 N3 O3 CC(C)c1cc(....
84 4AWP ic50 = 81 nM 99A C30 H33 N5 O3 Cc1cc(c(cc....
85 2XJG Kd = 0.015 uM XJG C19 H21 N O3 CC(C)c1cc(....
86 4CWT Ki = 0.179 uM IK9 C19 H17 F N6 O3 c1cc2c(cc1....
87 4O09 Ki = 0.02 uM 2R6 C24 H30 N2 O2 Cc1cn(c2c1....
88 2BT0 ic50 = 5.7 uM CT5 C20 H20 N2 O4 CCc1cc(c(c....
89 2QG0 Ki = 1.9 uM A94 C17 H19 N5 O4 S Cc1cc(nc(n....
90 2XK2 Kd = 10 uM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3R91 ic50 = 0.092 uM 06H C25 H32 N4 O3 Cc1c2n(c3c....
92 2CCS ic50 = 2 uM 4BH C13 H15 Cl N4 O2 c1c(c(cc(c....
93 2YKJ - YKJ C25 H18 N6 O c1ccc2c(c1....
94 6GPY - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
95 5OCI Kd = 9 nM 9R8 C27 H28 N4 O3 Cc1cccc(c1....
96 4FCP - 42C C7 H9 N5 CN(C)c1c2c....
97 5J2X Kd = 0.00000145 M 6DL C14 H9 Br F N3 O3 c1ccc(c(c1....
98 3WHA Kd = 0.48 nM WHA C19 H18 Cl N5 O2 S c1cc2c3c(c....
99 6GR3 - AN2 C10 H16 N6 O9 P2 c1nc(c2c(n....
100 6EY8 Kd = 1.55 uM C4T C23 H20 Cl N3 O2 CN(Cc1ccc(....
101 2YEA - 2A9 C8 H10 O3 COc1ccc(cc....
102 2YI7 Kd = 4.8 nM BZ8 C16 H13 Cl N2 O3 S CCOc1ccc(c....
103 2YE2 - XQI C9 H10 O4 COC(=O)Cc1....
104 6F1N Kd = 0.547 uM C8W C20 H19 N5 O5 S COc1ccc(cc....
105 4CWO Ki = 6.1 uM T62 C16 H13 N5 O2 c1ccc2c(c1....
106 5J8M Kd = 0.00000145 M 6DL C14 H9 Br F N3 O3 c1ccc(c(c1....
107 4U93 ic50 = 0.013 uM 990 C20 H18 F N5 O2 Cc1c2c(nc(....
108 4CWS Ki = 0.012 uM G3R C19 H18 N6 O3 c1cc2c(cc1....
109 2BYH ic50 = 0.258 uM 2D7 C18 H14 Cl N3 O4 CC(=O)c1cc....
110 4EGI ic50 = 150 uM B2J C6 H10 N4 S CCSc1nc(nc....
111 1OSF - KOS C32 H48 N4 O8 C[C@H]1C[C....
112 3K97 Ki = 10 nM 4CD C18 H18 Cl N O3 Cc1ccccc1[....
113 2YED - ADE C5 H5 N5 c1[nH]c2c(....
114 6CEO - D57 C22 H22 N2 O6 COC(=O)c1c....
115 2YKC - YKC C25 H17 N5 O c1ccc2c(c1....
116 6GPT - A12 C11 H17 N5 O9 P2 c1nc(c2c(n....
117 5VYY Kd = 0.62 uM 9QY C20 H19 Cl N2 O4 COC(=O)c1c....
118 2WI2 ic50 = 350 uM ZZ3 C5 H8 N4 S Cc1nc(nc(n....
119 6GPF - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
120 2YE7 - 2GA C8 H10 N4 S3 Cc1c(c(n[n....
121 1UYF ic50 = 30 uM PU1 C20 H21 Cl F N5 O3 COc1cc(c(c....
122 3VHC Kd = 1.3 nM VHC C22 H22 N4 O2 S Cc1cc(c2cc....
123 2YK2 - YJX C18 H14 N4 O c1ccc2c(c1....
124 5J64 Kd = 0.00000145 M 6G7 C14 H10 F N3 O3 c1ccc(c(c1....
125 2XHR Kd = 0.0048 uM C0P C16 H17 Cl3 N4 O2 c1c(c(cc(c....
126 3R92 ic50 = 0.883 uM 06J C26 H34 N4 O2 Cc1c2n(c3c....
127 2CCT ic50 = 6.3 uM 2E1 C16 H20 Cl N5 O3 CCNC(=O)c1....
128 4XIR Ki = 115 nM 40X C23 H27 Cl N2 O3 CCC[C@H]1C....
129 4CWN Ki = 2.6 uM 6LV C18 H17 N5 O2 COc1cc(cc(....
130 1YET - GDM C29 H40 N2 O9 C[C@H]1C[C....
131 3QDD ic50 = 5.1 nM 94M C14 H15 Cl N6 O Cc1cnc(c(c....
132 6GPO - CMP C10 H12 N5 O6 P c1nc(c2c(n....
133 2H55 - DZ8 C19 H22 F I N6 O2 CC(C)NCCCn....
134 1UYK ic50 = 17.1 uM PUX C17 H18 F N5 O2 CCCCn1c(nc....
135 2XDS - MT0 C9 H7 Cl N2 Cc1c2ccccc....
136 2WI1 ic50 > 4000 uM ZZ2 C8 H13 N3 O2 Cc1cc(nc(n....
137 4FCR Kd = 0.4 nM 0TM C19 H18 Cl N5 O3 S CN(C)C(=O)....
138 5FNF Kd = 700 uM TQL C12 H10 N2 O3 c1cc(cnc1)....
139 5J27 Kd = 0.00000145 M 6FF C18 H19 F N4 O5 S CCCN(C)S(=....
140 2YEC - XQ0 C8 H8 N2 O Cc1c2ccc(c....
141 4CWQ Ki = 0.088 uM W2D C17 H14 N6 O4 S c1cc2c(cc1....
142 2YE4 - 2FY C9 H10 O3 CCC(=O)c1c....
143 2BSM ic50 = 1.5 uM BSM C19 H18 Cl N3 O4 CCNC(=O)c1....
144 2YKI Kd = 0.35 nM YKI C27 H18 N6 O c1ccc2c(c1....
145 3RLQ Ki = 0.04 uM 3RQ C15 H10 Cl2 N4 O Cc1nc(c2c(....
146 3MNR - SD1 C27 H31 N3 O5 Cc1cc2c(n1....
147 3K99 Ki = 60 nM PFT C15 H13 N O3 c1ccc2c(c1....
148 5LNZ - 70Z C25 H31 N5 O4 CCCCN(C)C(....
149 5J20 Kd = 0.00000145 M 6FJ C21 H17 F N4 O5 CN(Cc1ccco....
150 6GQR - APC C11 H18 N5 O12 P3 c1nc(c2c(n....
151 2YEF - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
152 3B28 Kd = 0.0034 uM B2X C16 H13 Cl N4 O S CSc1nc(nc(....
153 3R4P Ki = 0.011 uM FU7 C21 H21 Cl2 F2 N7 O2 CC(CNC(=O)....
154 4NH8 Ki = 3 nM 2LC C22 H26 F N3 O3 Cc1cn(c2c1....
155 6ELN Kd = 0.9 uM P4A C17 H16 N2 O3 Cc1c(c(n[n....
156 2XDK Kd = 250 uM XDK C9 H8 N4 c1cc(cnc1)....
157 2VCI ic50 = 0.021 uM 2GJ C26 H31 N3 O5 CCNC(=O)c1....
158 5M4E - 7F9 C18 H20 N2 O5 CCNC(=O)CN....
159 3QTF ic50 = 0.11 uM 05S C24 H32 N4 O2 Cc1c2n(c3c....
160 6EYB Kd = 4.22 uM C3Z C23 H18 N4 O c1ccc(cc1)....
161 2WI5 ic50 = 0.9 uM ZZ5 C17 H15 N5 O2 S CCOc1ccc(c....
162 2XAB Kd = 0.54 nM VHD C18 H19 N O3 CC(C)c1cc(....
163 2UWD Kd = 4.5 nM 2GG C19 H17 Cl N2 O5 CCNC(=O)c1....
164 1UYH ic50 = 14.3 uM PU0 C18 H22 F N5 O2 CCCCn1c(nc....
165 6GP8 - APC C11 H18 N5 O12 P3 c1nc(c2c(n....
166 2XDL Kd = 790 uM 2DL C12 H17 N O3 CCN(CC)C(=....
167 5J82 Kd = 0.00000145 M 6GV C18 H19 F N4 O5 S CC(C)N(C)S....
168 4L91 - X29 C12 H7 Br Cl N3 O2 c1cc2nnc(n....
169 6GR1 - APC C11 H18 N5 O12 P3 c1nc(c2c(n....
170 6GQ6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
171 3RKZ ic50 = 0.083 uM 06T C28 H39 N5 O3 Cc1c2n(c3c....
172 5LO0 - 70N C28 H26 F2 N6 O3 S CN1CCN(CC1....
173 4EEH ic50 = 45 uM HH6 C13 H10 N2 O2 c1cc(ccc1c....
174 2YE8 - 2D3 C9 H9 N3 O3 Cc1c(c(n[n....
175 2YI6 - 6QM C18 H18 N2 O3 S CCc1cc(c(c....
176 2YJX - YJX C18 H14 N4 O c1ccc2c(c1....
177 4CWP Ki = 0.17 uM TV2 C17 H13 N5 O2 c1ccc2c(c1....
178 4NH7 Ki = 4 nM HIE C23 H27 F3 N4 O3 CC1(Cc2c(c....
179 6EY9 Kd = 1.24 uM C4N C24 H22 Cl N3 O2 Cc1cccc(c1....
180 4EFU ic50 = 0.25 uM EFU C24 H23 N3 O2 Cc1cccc(c1....
181 5NYH Kd = 18.7 nM 9EK C24 H27 N5 O4 CN(c1ccc(c....
182 2YJW - YJW C16 H13 N O3 Cc1c(c(no1....
183 4O05 Ki = 0.037 uM 2Q9 C26 H34 N4 O2 CC(C)Nc1cc....
184 3B25 Kd = 0.86 uM B2K C12 H13 N3 O2 S Cc1ccc(cc1....
185 3OW6 - MEX C13 H10 N2 O3 c1ccc2c(c1....
186 3FT8 ic50 = 0.03 uM MOJ C20 H18 F N5 O Cc1c2c(nc(....
187 4EGH ic50 = 550 uM 0OY C11 H13 N O3 c1cc(ccc1C....
188 5ZR3 ic50 = 98 nM 9J0 C24 H24 N8 O Cc1cc(ccc1....
189 3INW ic50 = 0.039 uM JZB C24 H29 Cl N2 O6 c1c(c2c(c(....
190 3HHU ic50 = 41 nM 819 C21 H24 N4 O4 S CCOC(=O)NC....
191 6GPR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
192 4BQJ - XKL C18 H15 N3 O7 CCNC(=O)c1....
193 4O0B Ki = 0.005 uM 2QA C25 H30 N2 O2 Cc1cn(c2c1....
194 4JQL ic50 = 1 uM VJ6 C28 H41 N3 O9 C[C@H]1/C=....
195 1UYC ic50 = 41 uM PU7 C18 H23 N5 O2 CCCCn1c(nc....
196 2YE9 - 2D4 C20 H15 N O4 S2 c1ccc2c(c1....
197 2FWY ic50 = 200 nM H64 C18 H21 Br N6 O2 S CC(C)NCCCn....
198 3R4M Ki = 1.2 uM WOE C11 H10 Cl N3 O COc1ccccc1....
199 6ELP Kd = 0.236 uM BA8 C22 H18 Cl N3 O2 c1ccc(c(c1....
200 5J86 Kd = 0.00000145 M 6GW C22 H20 N4 O4 S Cc1ccccc1N....
201 4EGK ic50 = 40 nM RDC C18 H17 Cl O6 C[C@@H]1C[....
202 5FND Kd = 320 uM IQ5 C10 H11 N3 O S Cc1cc2c(cc....
203 3BM9 ic50 = 0.19 uM BXZ C13 H8 Br N O4 c1cc2c(cc1....
204 4FCQ Kd = 0.156 uM 2N6 C16 H14 N4 S Cc1ccc(c(c....
205 5GGZ ic50 = 0.056 uM 6TN C19 H23 N3 O4 CCOc1ncc2c....
206 1TC0 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
207 1U2O - NEC C12 H16 N6 O4 CCNC(=O)[C....
208 1TC6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
209 1U0Z - RDC C18 H17 Cl O6 C[C@@H]1C[....
210 1TBW - AMP C10 H14 N5 O7 P c1nc(c2c(n....
211 6ASQ - VC4 C22 H20 Cl N O4 COC(=O)c1c....
212 1YT0 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
213 2EXL - GDM C29 H40 N2 O9 C[C@H]1C[C....
214 2GFD Kd = 0.87 uM RDA C18 H18 Cl N O8 COc1cc(c(c....
215 2YI0 Kd = 7.5 nM YI0 C15 H11 Cl N2 O3 S COc1ccc(cc....
216 2QFO Ki = 18 uM A13 C6 H6 F3 N3 Cc1cc(nc(n....
217 2WI7 ic50 = 0.058 uM 2KL C21 H23 Cl2 N5 O2 S CCNC(=O)c1....
218 2YEI - XQK C9 H9 N3 O3 Cc1c(c([nH....
219 5J6L Kd = 0.00000145 M 6GC C20 H21 F N4 O4 CCCCN(C)C(....
220 5ODX Kd = 195 nM 9RZ C26 H31 N5 O5 CN(c1ccc(c....
221 3RLP Kd = 0.084 uM 3RP C12 H11 Cl2 N3 O Cc1cc(nc(n....
222 2IOR - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
223 4XDM - GDM C29 H40 N2 O9 C[C@H]1C[C....
224 4XC0 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
225 4XCJ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
226 4XCL - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
227 4XD8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
228 1QYE - CDY C10 H12 Cl N5 O2 c1nc2c(nc(....
229 1QY8 - RDI C18 H23 Cl O6 C[C@@H]1C[....
230 6D28 Kd = 200 nM NEC C12 H16 N6 O4 CCNC(=O)[C....
231 2BRC ic50 = 7.1 uM CT5 C20 H20 N2 O4 CCc1cc(c(c....
232 4CE3 - L4V C18 H22 Cl N O4 CN1CCC/C=C....
233 2VW5 Ki = 3 nM BC6 C28 H42 N2 O6 C[C@H]1CCC....
234 4ASA - 59C C32 H45 N3 O8 C[C@H]1C[C....
235 1BGQ Kd = 2.7 nM RDC C18 H17 Cl O6 C[C@@H]1C[....
236 2XX2 - 13C C17 H20 Cl N O4 c1c(c2c(c(....
237 2WEP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
238 2WER Kd = 90 nM RDC C18 H17 Cl O6 C[C@@H]1C[....
239 2YGA Kd = 24.5 uM GDM C29 H40 N2 O9 C[C@H]1C[C....
240 2FXS Kd = 0.52 uM RDA C18 H18 Cl N O8 COc1cc(c(c....
241 2XX4 - 13I C20 H26 Cl N O6 CCO[C@H]([....
242 1AM1 Kd = 132 mM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
243 2XD6 ic50 = 0.011 uM XD6 C18 H19 Cl O6 c1c(c2c(c(....
244 2CGF Kd = 0.39 uM P2N C17 H19 Cl O5 c1c(c2c(c(....
245 1AMW Kd = 29 uM ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
246 4ASG - 814 C35 H44 N2 O9 C[C@H]1C[C....
247 1A4H - GDM C29 H40 N2 O9 C[C@H]1C[C....
248 4CE2 - BO5 C19 H24 Cl N O4 CN1CC/C=C/....
249 2BRE ic50 < 1 uM KJ2 C18 H18 Cl N3 O3 c1cc(ccc1c....
250 2IWX Kd = 0.21 uM M1S C18 H21 Cl O5 c1c(c2c(c(....
251 2XX5 - 13N C25 H27 Cl N2 O5 c1ccc(cc1)....
252 2YGF Kd = 12 uM GDM C29 H40 N2 O9 C[C@H]1C[C....
253 2VWC Ki = 0.24 uM BC2 C30 H42 N2 O8 C[C@H]1C[C....
254 4CE1 - 7FK C20 H26 Cl N O4 CN1CC/C=C/....
255 2WEQ Kd = 1.27 uM GDM C29 H40 N2 O9 C[C@H]1C[C....
256 2YGE Kd = 24.5 uM GDM C29 H40 N2 O9 C[C@H]1C[C....
257 5F5R - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
258 3NMQ - 7PP C21 H24 Cl N5 O2 Cc1cnc(c(c....
259 5UCJ Kd = 0.44 uM KU3 C19 H17 F N2 O3 CC(C)c1cc(....
260 1UYM - PU3 C19 H25 N5 O3 CCCCn1c(nc....
261 5UC4 Kd = 0.35 uM 83S C19 H19 N O3 CC(C)c1cc(....
262 3K60 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
263 1YC3 Kd = 0.68 uM 4BC C19 H16 N2 O6 CCc1cc(c(c....
264 1YC4 Kd = 0.28 uM 43P C14 H14 N4 O2 CCc1cc(c(c....
265 1YC1 Kd = 0.68 uM 4BC C19 H16 N2 O6 CCc1cc(c(c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ACP; Similar ligands found: 368
No: Ligand ECFP6 Tc MDL keys Tc
1 ACP 1 1
2 ACQ 0.866667 1
3 A2D 0.857143 0.945205
4 6YZ 0.833333 1
5 BA3 0.833333 0.945205
6 AP5 0.821918 0.945205
7 B4P 0.821918 0.945205
8 ADP 0.821918 0.972222
9 AT4 0.810811 0.933333
10 AN2 0.810811 0.958904
11 AP2 0.808219 0.986301
12 A12 0.808219 0.986301
13 M33 0.8 0.932432
14 HEJ 0.789474 0.972222
15 ATP 0.789474 0.972222
16 5FA 0.779221 0.972222
17 AR6 0.779221 0.945205
18 AQP 0.779221 0.972222
19 APR 0.779221 0.945205
20 AGS 0.769231 0.921053
21 SAP 0.769231 0.921053
22 AD9 0.769231 0.945946
23 AMP 0.763889 0.944444
24 A 0.763889 0.944444
25 APC 0.75641 0.986301
26 CA0 0.753247 0.92
27 ADX 0.753247 0.851852
28 ANP 0.75 0.945946
29 50T 0.74359 0.932432
30 PRX 0.734177 0.87013
31 ABM 0.733333 0.893333
32 ATF 0.731707 0.933333
33 SRA 0.706667 0.894737
34 A22 0.705882 0.958904
35 RBY 0.703704 0.959459
36 ADV 0.703704 0.959459
37 5AL 0.698795 0.906667
38 A3R 0.689655 0.909091
39 A1R 0.689655 0.909091
40 ADQ 0.689655 0.92
41 AU1 0.6875 0.945946
42 TAT 0.686747 0.933333
43 T99 0.686747 0.933333
44 SRP 0.682353 0.907895
45 9X8 0.674157 0.896104
46 OAD 0.674157 0.92
47 4TC 0.673469 0.922078
48 4AD 0.670455 0.921053
49 AMO 0.670455 0.933333
50 00A 0.662921 0.860759
51 ADP PO3 0.662651 0.917808
52 3OD 0.659341 0.92
53 BIS 0.659341 0.909091
54 25A 0.659091 0.945205
55 OOB 0.659091 0.906667
56 8QN 0.659091 0.906667
57 5SV 0.659091 0.82716
58 SON 0.654321 0.933333
59 25L 0.652174 0.958904
60 PAJ 0.651685 0.8625
61 DLL 0.644444 0.906667
62 AHX 0.644444 0.897436
63 TXA 0.641304 0.907895
64 3UK 0.637363 0.894737
65 ALF ADP 0.632184 0.848101
66 ADP ALF 0.632184 0.848101
67 PR8 0.630435 0.851852
68 WAQ 0.630435 0.884615
69 B5V 0.630435 0.883117
70 LAD 0.630435 0.8625
71 MAP 0.629214 0.921053
72 LMS 0.628205 0.807229
73 GAP 0.627907 0.87013
74 VO4 ADP 0.625 0.906667
75 ADP VO4 0.625 0.906667
76 PTJ 0.623656 0.873418
77 FYA 0.623656 0.906667
78 ME8 0.623656 0.841463
79 1ZZ 0.623656 0.819277
80 NB8 0.623656 0.897436
81 UP5 0.62 0.896104
82 G3A 0.618557 0.897436
83 G5P 0.612245 0.897436
84 AFH 0.612245 0.886076
85 9SN 0.610526 0.85
86 DQV 0.606061 0.932432
87 GTA 0.606061 0.864198
88 9ZD 0.604396 0.884615
89 9ZA 0.604396 0.884615
90 YAP 0.604167 0.896104
91 FA5 0.604167 0.907895
92 B5Y 0.604167 0.871795
93 B5M 0.604167 0.871795
94 TXD 0.60396 0.884615
95 XAH 0.597938 0.841463
96 ADN 0.597222 0.821918
97 RAB 0.597222 0.821918
98 XYA 0.597222 0.821918
99 GA7 0.59596 0.907895
100 48N 0.594059 0.897436
101 DAL AMP 0.593407 0.881579
102 2A5 0.593023 0.92
103 AOC 0.592593 0.8
104 4UV 0.591837 0.871795
105 NXX 0.588235 0.907895
106 6V0 0.588235 0.873418
107 NAX 0.588235 0.875
108 DND 0.588235 0.907895
109 NAI 0.588235 0.884615
110 ATR 0.586207 0.944444
111 PAP 0.586207 0.958333
112 ADP BMA 0.585106 0.894737
113 LAQ 0.584158 0.819277
114 5AS 0.583333 0.761364
115 OMR 0.582524 0.831325
116 TXE 0.582524 0.884615
117 5N5 0.581081 0.797297
118 4UU 0.58 0.871795
119 A A 0.578947 0.918919
120 7D3 0.578313 0.881579
121 AP0 0.576923 0.873418
122 A4D 0.573333 0.797297
123 5CD 0.573333 0.783784
124 JB6 0.572917 0.884615
125 4UW 0.572816 0.839506
126 A4P 0.571429 0.823529
127 CNA 0.570093 0.907895
128 ITT 0.569767 0.917808
129 7D4 0.569767 0.881579
130 A2R 0.565217 0.958904
131 M2T 0.564103 0.716049
132 YLP 0.563107 0.821429
133 139 0.560748 0.851852
134 ADJ 0.560748 0.831325
135 T5A 0.560748 0.843373
136 TAD 0.558824 0.910256
137 ATP A A A 0.555556 0.905405
138 A3P 0.552941 0.944444
139 TYM 0.552381 0.907895
140 IOT 0.551402 0.833333
141 EP4 0.551282 0.734177
142 MYR AMP 0.55102 0.797619
143 F2R 0.550459 0.865854
144 7D5 0.55 0.855263
145 A3D 0.54955 0.894737
146 80F 0.54955 0.843373
147 GCP 0.548387 0.922078
148 UPA 0.54717 0.884615
149 YLC 0.54717 0.841463
150 YLB 0.54717 0.821429
151 NAD 0.545455 0.906667
152 COD 0.545455 0.813953
153 G5A 0.544444 0.781609
154 HFD 0.544444 0.921053
155 DTA 0.544304 0.766234
156 3DH 0.54321 0.753247
157 DZD 0.540541 0.910256
158 AHZ 0.538462 0.797619
159 MTA 0.5375 0.753247
160 3AM 0.536585 0.90411
161 A2P 0.534884 0.930556
162 AR6 AR6 0.533981 0.893333
163 PPS 0.532609 0.851852
164 6AD 0.532609 0.886076
165 YLA 0.53211 0.821429
166 TYR AMP 0.529412 0.871795
167 AMP DBH 0.529412 0.87013
168 AYB 0.527273 0.811765
169 A5A 0.526882 0.788235
170 TSB 0.526316 0.8
171 6RE 0.52381 0.7625
172 S4M 0.523256 0.670455
173 SSA 0.521277 0.802326
174 NA7 0.520408 0.959459
175 7MD 0.519231 0.864198
176 ARG AMP 0.519231 0.831325
177 LPA AMP 0.518868 0.797619
178 BTX 0.517857 0.843373
179 NAE 0.517241 0.871795
180 54H 0.515789 0.770115
181 52H 0.515789 0.761364
182 VMS 0.515789 0.770115
183 BT5 0.513274 0.833333
184 NAQ 0.512821 0.85
185 ZAS 0.511905 0.746835
186 J7C 0.511628 0.772152
187 A3N 0.511628 0.766234
188 IMO 0.511628 0.90411
189 AV2 0.510638 0.893333
190 53H 0.510417 0.761364
191 8X1 0.510417 0.755556
192 5CA 0.510417 0.802326
193 ARU 0.510204 0.839506
194 AF3 ADP 3PG 0.509259 0.839506
195 M24 0.508621 0.829268
196 ZID 0.508475 0.894737
197 2AM 0.506024 0.917808
198 V3L 0.505376 0.945205
199 3AT 0.505376 0.972222
200 AVV 0.505155 0.897436
201 NSS 0.5 0.802326
202 EAD 0.5 0.851852
203 DSZ 0.5 0.802326
204 MAO 0.5 0.761905
205 LSS 0.5 0.764045
206 DSH 0.5 0.728395
207 P5A 0.5 0.747253
208 YLY 0.495726 0.811765
209 9K8 0.49505 0.698925
210 NVA LMS 0.494949 0.755556
211 DAT 0.494505 0.906667
212 5X8 0.494505 0.766234
213 AMP NAD 0.491228 0.881579
214 7MC 0.490909 0.843373
215 LEU LMS 0.49 0.755556
216 SMM 0.489583 0.689655
217 SAM 0.489362 0.694118
218 DTP 0.489362 0.906667
219 7DD 0.488889 0.958333
220 GJV 0.488636 0.753086
221 OVE 0.488372 0.881579
222 5AD 0.486842 0.726027
223 GSU 0.485149 0.781609
224 KAA 0.485149 0.755556
225 P1H 0.483871 0.831325
226 NDE 0.483871 0.907895
227 N0B 0.483333 0.821429
228 A3G 0.482759 0.802632
229 NAJ PZO 0.478632 0.82716
230 4TA 0.478261 0.809524
231 SFG 0.478261 0.753247
232 NDC 0.47619 0.85
233 YSA 0.47619 0.781609
234 FB0 0.47619 0.827586
235 7DT 0.473118 0.958333
236 A7D 0.472527 0.779221
237 NJP 0.469565 0.921053
238 FDA 0.46875 0.835294
239 SA8 0.468085 0.710843
240 A5D 0.468085 0.766234
241 MHZ 0.467391 0.701149
242 8PZ 0.466667 0.802326
243 71V 0.466667 0.884615
244 G A A A 0.465517 0.85
245 0WD 0.465517 0.897436
246 6FA 0.465116 0.843373
247 GGZ 0.464646 0.804878
248 SAI 0.463158 0.7375
249 SAH 0.463158 0.746835
250 6C6 0.463158 0.883117
251 NAJ PYZ 0.46281 0.788235
252 Y3J 0.4625 0.706667
253 7D7 0.461538 0.723684
254 TXP 0.46087 0.897436
255 PO4 PO4 A A A A PO4 0.460784 0.878378
256 S7M 0.459184 0.694118
257 6IA 0.458333 0.839506
258 DDS 0.458333 0.855263
259 FAS 0.458015 0.853659
260 FAD 0.458015 0.853659
261 SFD 0.458015 0.736842
262 ODP 0.456897 0.886076
263 A3S 0.456522 0.813333
264 U A 0.453782 0.884615
265 7C5 0.453704 0.797468
266 EEM 0.453608 0.694118
267 AAT 0.453608 0.710843
268 A G 0.452991 0.860759
269 RGT 0.45283 0.933333
270 NPW 0.452174 0.8875
271 NDP 0.452174 0.897436
272 FAY 0.451852 0.864198
273 PGS 0.451613 0.860759
274 D5M 0.449438 0.88
275 DA 0.449438 0.88
276 NEC 0.449438 0.727273
277 U A G G 0.449153 0.860759
278 2SA 0.44898 0.933333
279 NIA 0.448276 0.802469
280 NZQ 0.448276 0.910256
281 A U 0.447368 0.848101
282 A3T 0.446809 0.8
283 A A A 0.446602 0.906667
284 128 0.446429 0.758621
285 6K6 0.445545 0.905405
286 GEK 0.445545 0.740741
287 4YB 0.445455 0.764045
288 AAM 0.444444 0.944444
289 FNK 0.444444 0.806818
290 62F 0.444444 0.864198
291 Z5A 0.443548 0.761364
292 WSA 0.442478 0.790698
293 AMZ 0.44186 0.891892
294 C2R 0.44186 0.88
295 12D 0.441441 0.767442
296 XNP 0.440678 0.851852
297 RFL 0.437956 0.823529
298 62X 0.436893 0.670455
299 N6P 0.436893 0.890411
300 AIR 0.433735 0.876712
301 GP3 0.43299 0.897436
302 A6D 0.432692 0.705882
303 V1N 0.431193 0.893333
304 649 0.429825 0.747253
305 GP2 0.428571 0.910256
306 GDP 0.428571 0.896104
307 NA0 0.428571 0.907895
308 0UM 0.427184 0.702381
309 ETB 0.42623 0.835294
310 DCA 0.42623 0.825581
311 8Q2 0.426087 0.775281
312 9JJ 0.425532 0.841463
313 GNH 0.424242 0.884615
314 NAP 0.424 0.92
315 PUA 0.422764 0.8625
316 APU 0.422414 0.871795
317 101 0.422222 0.855263
318 3AD 0.421687 0.808219
319 FA9 0.42069 0.865854
320 TAP 0.420635 0.884615
321 TM1 0.420561 0.755814
322 P5F 0.41958 0.825581
323 0T1 0.419355 0.825581
324 COA 0.419355 0.825581
325 K15 0.419048 0.686047
326 7RP 0.417582 0.902778
327 S8M 0.417476 0.7625
328 NHD 0.416667 0.881579
329 GTP 0.415842 0.896104
330 FCX 0.414062 0.797753
331 F2N 0.413793 0.816092
332 AS 0.413043 0.835443
333 7RA 0.413043 0.931507
334 G1R 0.411765 0.884615
335 SXZ 0.411215 0.714286
336 ACK 0.411111 0.837838
337 QQY 0.411111 0.794872
338 CAO 0.409449 0.797753
339 COS 0.409449 0.806818
340 DG1 0.409449 0.897436
341 30N 0.409449 0.755319
342 AMX 0.409449 0.835294
343 1DG 0.409449 0.897436
344 J7V 0.409449 0.813953
345 EO7 0.408602 0.770115
346 8BR 0.408602 0.883117
347 NVA 2AD 0.408163 0.7625
348 D3Y 0.407767 0.792208
349 GSP 0.407767 0.851852
350 9GM 0.407767 0.873418
351 GNP 0.407767 0.873418
352 G2P 0.407767 0.910256
353 CC5 0.407407 0.819444
354 KB1 0.407407 0.702381
355 N01 0.406504 0.881579
356 A C A C 0.406504 0.82716
357 SCO 0.40625 0.825581
358 CMX 0.40625 0.825581
359 HDV 0.405941 0.87013
360 CMP 0.404255 0.876712
361 2BA 0.404255 0.890411
362 ACO 0.403101 0.797753
363 FAM 0.403101 0.806818
364 2VA 0.402062 0.779221
365 3NZ 0.401869 0.78481
366 HAX 0.4 0.806818
367 QQX 0.4 0.78481
368 26A 0.4 0.74359
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4XCL; Ligand: AGS; Similar sites found with APoc: 114
This union binding pocket(no: 1) in the query (biounit: 4xcl.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 4V1F BQ1 None
2 3KPE TM3 None
3 2ZFZ ARG None
4 1L6O SER LEU LYS LEU MET THR THR VAL None
5 3EHH ADP 0.917431
6 1B63 ANP 1.1583
7 1ID0 ANP 1.31579
8 4URN NOV 1.33333
9 4WGF HX2 1.46341
10 3EHG ATP 1.5625
11 4GGL CJC 1.86047
12 5CKS GAL 1.9305
13 3AI3 SOE 1.9305
14 5EOO CIT 1.9305
15 1J78 VDY 1.9305
16 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 2.3166
17 1S16 ANP 2.3166
18 3THR C2F 2.3166
19 5X3R 7Y3 2.43902
20 4RW3 TDA 2.7027
21 4RW3 PLM 2.7027
22 5AZC PGT 2.7027
23 1TO9 HMH 2.7027
24 5G5W R8C 2.7027
25 6ER9 FAD 2.7027
26 6ER9 NAP 2.7027
27 4HZ0 1AV 2.8169
28 4HY1 19X 3.0888
29 4ZVI 4S4 3.0888
30 2WR1 NAG 3.0888
31 2BCG GER 3.0888
32 3RS8 ALA TRP LEU PHE GLU ALA 3.0888
33 1VAY AZA 3.0888
34 1M3U KPL 3.0888
35 1S14 NOV 3.09278
36 5OCA 9QZ 3.22581
37 2ZKJ ADP 3.4749
38 2GWH PCI 3.4749
39 2BP1 FLC 3.4749
40 4ZUL UN1 3.4749
41 5WZE PRO 3.4749
42 2C2A ADP 3.48837
43 5UC9 MYR 3.53982
44 6CB2 OLC 3.861
45 1ZED PNP 3.861
46 1LT3 GAL BGC 3.8835
47 1A05 IPM 4.2471
48 4TV1 36M 4.38247
49 1KZN CBN 4.39024
50 1TID ATP 4.41176
51 1ZXM ANP 4.6332
52 5J6A P46 4.6332
53 5OLK DTP 4.6332
54 3X01 AMP 4.6332
55 5U97 PIT 4.6332
56 1DL2 NAG NAG BMA 4.6332
57 3NB0 G6P 5.01931
58 4URL XAM 5.01931
59 4ZGM 32M 5.01931
60 5IDM ANP 5.02793
61 1I58 ADP 5.29101
62 1I58 ACP 5.29101
63 4EMV 0R9 5.30973
64 1QZR CDX 5.40541
65 1QZR ANP 5.40541
66 1XVB 3BR 5.40541
67 3CHT 4NB 5.40541
68 5AAV GW5 5.55556
69 1GKZ ADP 5.79151
70 4DE3 DN8 5.79151
71 2YFB SIN 5.81395
72 4UAP NGA 5.92105
73 2PYU IMP 5.93607
74 1OYJ GSH 6.06061
75 5J32 IPM 6.17761
76 1DTL BEP 6.21118
77 4BAE RWX 6.34146
78 3E70 GDP 6.40244
79 5XJ7 87O 6.46766
80 4PL9 ADP 6.55738
81 2HHP FLC 6.56371
82 3TTZ 07N 6.56566
83 2D5X L35 6.84932
84 2BHW NEX 6.89655
85 1V0C ACO 6.93069
86 1V0C KNC 6.93069
87 4BIX ADP 6.94981
88 3NHB ADP 6.94981
89 4P8O 883 6.95187
90 4OKD GLC GLC GLC 7.33591
91 1R6N 434 8.05687
92 2GBB CIT 8.33333
93 4QC6 30N 8.37989
94 1KIJ NOV 8.46154
95 1NF8 BOG 8.69565
96 5LX9 OLB 9.15493
97 1Y8O ADP 9.375
98 1LTT GAL BGC 9.7561
99 4B6C B5U 10.7143
100 5WZN A2G 11.1969
101 4GCZ ADP 11.583
102 1TV5 N8E 11.9691
103 2XDQ MGX 13.5135
104 4WZ6 ATP 13.5135
105 2B4B B33 14.0351
106 5LWY OLB 14.9533
107 2HKJ RDC 16.6023
108 3D36 ADP 17.3913
109 4F4S EFO 18.4211
110 1TH8 ADP 18.9655
111 1XX4 BAM 23.9382
112 5W97 CHD 25.4237
113 5ZCO CHD 25.4237
114 4OGQ 7PH 29.7297
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