Receptor
PDB id Resolution Class Description Source Keywords
4YAF 1.91 Å EC: 1.6.2.4 RAT CYPOR WITH 2'-AMP RATTUS NORVEGICUS CYTOCHROME P450 REDUCTASE FMN BINDING SEMIQUINONE OXIDORE
Ref.: MUTANTS OF CYTOCHROME P450 REDUCTASE LACKING EITHER OR GLY-143 DESTABILIZE ITS FMN SEMIQUINONE. J.BIOL.CHEM. V. 291 14639 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FMN A:701;
B:701;
Valid;
Valid;
none;
none;
submit data
456.344 C17 H21 N4 O9 P Cc1cc...
2AM A:703;
B:703;
Valid;
Valid;
none;
none;
submit data
347.221 C10 H14 N5 O7 P c1nc(...
FAD B:702;
A:702;
Valid;
Valid;
none;
none;
submit data
785.55 C27 H33 N9 O15 P2 Cc1cc...
PO4 B:704;
Invalid;
none;
submit data
94.971 O4 P [O-]P...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5FA6 2.3 Å EC: 1.6.2.4 WILD TYPE HUMAN CYPOR HOMO SAPIENS CYPOR CYTOCHROME P450 REDUCTASE FLAVOPROTEIN ABS-LIKE PHEOXIDOREDUCTASE
Ref.: INSTABILITY OF THE HUMAN CYTOCHROME P450 REDUCTASE VARIANT IS THE MAJOR CONTRIBUTOR TO ITS ANTLEY-BIXL SYNDROME-LIKE PHENOTYPE. J.BIOL.CHEM. V. 291 20487 2016
Members (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 3QFC - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 4YAF - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
3 3OJX - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 4Y9U - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
5 4Y9R - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
6 4YAL - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
7 4YAW - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
8 3OJW - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 5FA6 Ki = 16.1 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 4YAO - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
11 4YAU - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
12 4Y7C - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
13 3QFR - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
14 5EMN - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 1JA1 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
16 3QE2 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
70% Homology Family (19)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3QFC - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 4YAF - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
3 3OJX - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 4Y9U - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
5 4Y9R - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
6 4YAL - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
7 4YAW - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
8 3OJW - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 5FA6 Ki = 16.1 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 4YAO - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
11 4YAU - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
12 4Y7C - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
13 3QFR - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
14 5EMN - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 1JA1 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
16 3QE2 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
17 3FJO - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
18 3QFT - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
19 3QFS - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
50% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 3QFC - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 4YAF - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
3 3OJX - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 4Y9U - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
5 4Y9R - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
6 4YAL - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
7 4YAW - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
8 3OJW - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 5FA6 Ki = 16.1 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 4YAO - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
11 4YAU - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
12 4Y7C - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
13 3QFR - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
14 5EMN - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 1JA1 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
16 3QE2 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
17 3FJO - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
18 3QFT - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
19 3QFS - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
20 5GXU - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FMN; Similar ligands found: 16
No: Ligand ECFP6 Tc MDL keys Tc
1 FMN 1 1
2 RBF 0.75641 0.876712
3 RS3 0.571429 0.831169
4 FAS 0.543307 0.876543
5 FAD 0.543307 0.876543
6 FAE 0.539062 0.865854
7 DAL FAD PER 0.5 0.833333
8 LFN 0.475 0.643836
9 C3F 0.473684 0.74359
10 CF4 0.463918 0.734177
11 FAY 0.446043 0.864198
12 FNR 0.444444 0.909091
13 RFL 0.442857 0.845238
14 4LS 0.411215 0.875
15 1VY 0.406593 0.769231
16 DLZ 0.404494 0.782051
Ligand no: 2; Ligand: 2AM; Similar ligands found: 237
No: Ligand ECFP6 Tc MDL keys Tc
1 2AM 1 1
2 OVE 0.828125 0.957747
3 A2P 0.80597 0.956522
4 ATR 0.739726 0.971014
5 3AM 0.691176 0.956522
6 A2R 0.683544 0.930556
7 A22 0.675 0.930556
8 NA7 0.642857 0.905405
9 A3P 0.635135 0.942857
10 ADN 0.6 0.842857
11 RAB 0.6 0.842857
12 XYA 0.6 0.842857
13 7D5 0.591549 0.902778
14 AMP 0.589041 0.942857
15 A 0.589041 0.942857
16 25A 0.588235 0.916667
17 PAP 0.5875 0.957143
18 V3L 0.573171 0.916667
19 PPS 0.566265 0.848101
20 7D7 0.560606 0.763889
21 25L 0.549451 0.930556
22 ABM 0.545455 0.890411
23 A2D 0.545455 0.916667
24 ADP 0.544304 0.943662
25 101 0.539474 0.902778
26 SRA 0.539474 0.891892
27 7D3 0.538462 0.90411
28 AN2 0.5375 0.930556
29 2A5 0.536585 0.917808
30 5N5 0.536232 0.816901
31 PO4 PO4 A A A A PO4 0.533333 0.901408
32 AMP MG 0.532468 0.864865
33 AP2 0.531646 0.905405
34 A12 0.531646 0.905405
35 BA3 0.531646 0.916667
36 SAP 0.53012 0.893333
37 AGS 0.53012 0.893333
38 NDP 0.529412 0.87013
39 NPW 0.529412 0.8375
40 5CD 0.528571 0.777778
41 A4D 0.528571 0.816901
42 B4P 0.525 0.916667
43 AP5 0.525 0.916667
44 ATP 0.52439 0.943662
45 TXP 0.524272 0.87013
46 NZQ 0.524272 0.858974
47 ODP 0.519231 0.858974
48 NJP 0.519231 0.893333
49 SON 0.518519 0.88
50 5FA 0.518072 0.943662
51 AQP 0.518072 0.943662
52 APC 0.518072 0.905405
53 XNP 0.514286 0.848101
54 7D4 0.512195 0.90411
55 CA0 0.512195 0.891892
56 ADX 0.512195 0.825
57 M33 0.512195 0.90411
58 AU1 0.512195 0.917808
59 EP4 0.506849 0.727273
60 ACP 0.506024 0.917808
61 50T 0.506024 0.930556
62 AR6 0.5 0.916667
63 TAT 0.5 0.905405
64 M2T 0.5 0.708861
65 ACQ 0.5 0.917808
66 APR 0.5 0.916667
67 5AD 0.5 0.742857
68 PRX 0.5 0.866667
69 DTA 0.5 0.76
70 ADQ 0.494505 0.917808
71 ADV 0.494118 0.88
72 RBY 0.494118 0.88
73 AD9 0.494118 0.917808
74 ADP MG 0.493976 0.853333
75 A3G 0.493671 0.797297
76 MTA 0.493333 0.746667
77 Y3J 0.492958 0.722222
78 ATF 0.488636 0.905405
79 AV2 0.488636 0.916667
80 2VA 0.488095 0.797297
81 ADP BEF 0.488095 0.831169
82 BEF ADP 0.488095 0.831169
83 2GP 0.487805 0.905405
84 103 0.487179 0.835616
85 ACK 0.487179 0.913043
86 QQY 0.487179 0.863014
87 3AD 0.486111 0.828571
88 OAD 0.483871 0.891892
89 ANP 0.482759 0.917808
90 6RE 0.481013 0.75641
91 3DH 0.480519 0.746667
92 NAP 0.477876 0.891892
93 5AL 0.477273 0.878378
94 ADP PO3 0.476744 0.888889
95 DA 0.475 0.902778
96 D5M 0.475 0.902778
97 NEC 0.475 0.767123
98 AOC 0.475 0.794521
99 QQX 0.474359 0.851351
100 1DG 0.473684 0.87013
101 TAP 0.473684 0.857143
102 DG1 0.473684 0.87013
103 CC5 0.471429 0.788732
104 SO8 0.471264 0.786667
105 VRT 0.471264 0.766234
106 ATP MG 0.471264 0.853333
107 5X8 0.470588 0.736842
108 5AS 0.46988 0.755814
109 NA0 0.469565 0.88
110 ZAS 0.468354 0.74026
111 ADP BMA 0.468085 0.891892
112 5SV 0.467391 0.822785
113 SRP 0.466667 0.88
114 GAP 0.465909 0.866667
115 3AT 0.465909 0.943662
116 3L1 0.465753 0.794521
117 3D1 0.465753 0.794521
118 A3S 0.464286 0.808219
119 S4M 0.463415 0.662791
120 NVA 2AD 0.45977 0.786667
121 MAO 0.457831 0.73494
122 00A 0.457447 0.833333
123 DSH 0.45679 0.721519
124 MAP 0.456522 0.893333
125 ALF ADP 0.455556 0.820513
126 ADP ALF 0.455556 0.820513
127 DAT 0.453488 0.90411
128 SFG 0.453488 0.723684
129 A3T 0.453488 0.819444
130 APU 0.45283 0.893333
131 A A A 0.452632 0.853333
132 OOB 0.451613 0.878378
133 8QN 0.451613 0.878378
134 J7C 0.451219 0.766234
135 A3N 0.451219 0.783784
136 ANP MG 0.450549 0.844156
137 VO4 ADP 0.450549 0.878378
138 ADP VO4 0.450549 0.878378
139 A A 0.447917 0.916667
140 PR8 0.447917 0.825
141 A1R 0.446809 0.881579
142 4AD 0.446809 0.868421
143 AMO 0.446809 0.88
144 PAJ 0.446809 0.858974
145 GJV 0.445783 0.746835
146 0WD 0.445455 0.87013
147 NMN AMP PO4 0.445455 0.820513
148 UPA 0.443396 0.881579
149 PTJ 0.443299 0.846154
150 1ZZ 0.443299 0.792683
151 3OD 0.443299 0.891892
152 BIS 0.443299 0.881579
153 FYA 0.443299 0.878378
154 A5D 0.443182 0.76
155 SA8 0.443182 0.682927
156 DLL 0.442105 0.878378
157 AHX 0.442105 0.87013
158 AR6 AR6 0.441176 0.864865
159 DAL AMP 0.44086 0.853333
160 GGZ 0.44086 0.822785
161 CO7 0.439024 0.781609
162 TM1 0.438776 0.771084
163 SAH 0.438202 0.717949
164 SAI 0.438202 0.708861
165 G5A 0.438202 0.755814
166 3UK 0.4375 0.866667
167 S7M 0.434783 0.666667
168 SMM 0.434783 0.662791
169 9SN 0.434343 0.822785
170 5F1 0.434211 0.72973
171 OMR 0.433962 0.804878
172 AS 0.433735 0.855263
173 DTP 0.433333 0.90411
174 LAD 0.43299 0.835443
175 WAQ 0.43299 0.833333
176 SP1 0.432099 0.84
177 RP1 0.432099 0.84
178 A7D 0.430233 0.773333
179 ATP A A A 0.43 0.876712
180 NB8 0.428571 0.846154
181 TXA 0.428571 0.88
182 EEM 0.428571 0.666667
183 JB6 0.428571 0.833333
184 ME8 0.428571 0.792683
185 TSB 0.425532 0.77381
186 MHZ 0.425287 0.694118
187 MYR AMP 0.424242 0.771084
188 A5A 0.423913 0.761905
189 2BA 0.423529 0.887324
190 CMP 0.423529 0.9
191 ENP 0.42268 0.866667
192 ARJ 0.421053 0.746479
193 N01 0.421053 0.853333
194 GEK 0.421053 0.691358
195 SSA 0.419355 0.776471
196 NOC 0.418919 0.760563
197 P5A 0.418367 0.722222
198 SAM 0.417582 0.666667
199 DDS 0.417582 0.876712
200 YAP 0.415842 0.844156
201 FA5 0.415842 0.855263
202 52H 0.414894 0.735632
203 54H 0.414894 0.744186
204 VMS 0.414894 0.744186
205 AFH 0.413462 0.858974
206 ANZ 0.413462 0.820513
207 AAT 0.413043 0.703704
208 A U 0.412844 0.844156
209 XAH 0.411765 0.814815
210 NAI 0.411215 0.857143
211 ZDA 0.411111 0.837838
212 53H 0.410526 0.735632
213 5CA 0.410526 0.776471
214 D3Y 0.410526 0.786667
215 5J9 0.41 0.728395
216 K15 0.408163 0.658824
217 A6D 0.408163 0.698795
218 4UV 0.407767 0.844156
219 V1N 0.407767 0.890411
220 LAQ 0.40566 0.792683
221 ETB 0.405172 0.809524
222 DCA 0.405172 0.8
223 3NZ 0.40404 0.779221
224 G3A 0.403846 0.87013
225 AP0 0.40367 0.846154
226 5HG 0.402597 0.723684
227 AFX 0.402597 0.675325
228 NSS 0.402062 0.755814
229 0UM 0.402062 0.695122
230 LSS 0.402062 0.719101
231 DSZ 0.402062 0.755814
232 48N 0.401869 0.846154
233 PUA 0.401709 0.858974
234 7MD 0.4 0.8375
235 4UU 0.4 0.844156
236 G5P 0.4 0.87013
237 0XU 0.4 0.701299
Ligand no: 3; Ligand: FAD; Similar ligands found: 119
No: Ligand ECFP6 Tc MDL keys Tc
1 FAS 1 1
2 FAD 1 1
3 FAY 0.859259 0.9875
4 RFL 0.852941 0.963855
5 6FA 0.794118 0.987654
6 DAL FAD PER 0.772414 0.951807
7 FAE 0.751773 0.987654
8 SFD 0.651007 0.860215
9 FDA 0.641892 0.906977
10 FNK 0.602564 0.876405
11 62F 0.572327 0.939024
12 F2N 0.566265 0.886364
13 FMN 0.543307 0.876543
14 FA9 0.526316 0.939759
15 6YU 0.516304 0.860215
16 CNV FAD 0.511905 0.908046
17 P6G FDA 0.511628 0.908046
18 FAD NBT 0.508876 0.83871
19 A2D 0.504065 0.875
20 P5F 0.491329 0.941176
21 FAD CNX 0.488506 0.8125
22 APR 0.488372 0.851852
23 AR6 0.488372 0.851852
24 AGS 0.484615 0.811765
25 SAP 0.484615 0.811765
26 M33 0.484375 0.864198
27 BA3 0.484127 0.875
28 FAD NBA 0.480663 0.802083
29 ATP 0.48062 0.851852
30 B4P 0.480315 0.875
31 ADP 0.480315 0.851852
32 AP5 0.480315 0.875
33 ANP 0.477273 0.831325
34 AQP 0.476923 0.851852
35 5FA 0.476923 0.851852
36 48N 0.469388 0.902439
37 OAD 0.467626 0.876543
38 GTA 0.465753 0.892857
39 AN2 0.465116 0.841463
40 AD9 0.462121 0.831325
41 3OD 0.460993 0.876543
42 RBF 0.460938 0.790123
43 FB0 0.460606 0.835165
44 139 0.460526 0.858824
45 AP0 0.46 0.835294
46 A22 0.459854 0.864198
47 ACP 0.458015 0.853659
48 8QN 0.456522 0.864198
49 PRX 0.454545 0.831325
50 A1R 0.453237 0.86747
51 G3A 0.452055 0.902439
52 T5A 0.45098 0.872093
53 G5P 0.44898 0.902439
54 ATF 0.448529 0.821429
55 50T 0.44697 0.819277
56 ACQ 0.444444 0.853659
57 PAJ 0.442857 0.847059
58 ADQ 0.442857 0.853659
59 5AL 0.441176 0.864198
60 ADX 0.439394 0.775281
61 CA0 0.439394 0.853659
62 A4P 0.437909 0.831461
63 25L 0.4375 0.864198
64 P33 FDA 0.436464 0.817204
65 5SV 0.435714 0.793103
66 TXE 0.434211 0.890244
67 OMR 0.434211 0.818182
68 ABM 0.434109 0.829268
69 A 0.433071 0.82716
70 AMP 0.433071 0.82716
71 4AD 0.432624 0.855422
72 ADJ 0.432258 0.818182
73 BIS 0.430556 0.802326
74 SRA 0.429688 0.788235
75 AFH 0.42953 0.825581
76 TXD 0.427632 0.890244
77 NXX 0.427632 0.865854
78 UP5 0.427632 0.878049
79 DND 0.427632 0.865854
80 6V0 0.427632 0.857143
81 SRP 0.42446 0.843373
82 PR8 0.423611 0.837209
83 TAT 0.423358 0.821429
84 AMO 0.422535 0.865854
85 PTJ 0.42069 0.835294
86 FYA 0.42069 0.864198
87 TXA 0.42069 0.865854
88 CNA 0.420382 0.865854
89 00A 0.41958 0.823529
90 AHX 0.41958 0.835294
91 MAP 0.41844 0.811765
92 NAI 0.418301 0.845238
93 AU1 0.41791 0.831325
94 AP2 0.416667 0.843373
95 A12 0.416667 0.843373
96 25A 0.415493 0.851852
97 AMP MG 0.415385 0.785714
98 COD 0.415094 0.842697
99 ADP BEF 0.414815 0.77907
100 BEF ADP 0.414815 0.77907
101 4TC 0.412903 0.879518
102 APC 0.411765 0.843373
103 NB8 0.410959 0.835294
104 ME8 0.410959 0.806818
105 1ZZ 0.410959 0.806818
106 4UW 0.409091 0.825581
107 NAX 0.409091 0.837209
108 RBY 0.408759 0.843373
109 ADV 0.408759 0.843373
110 ADP MG 0.407407 0.797619
111 P1H 0.405882 0.818182
112 OOB 0.405594 0.864198
113 A A 0.40411 0.829268
114 LAD 0.40411 0.825581
115 UPA 0.403846 0.86747
116 4UU 0.401316 0.833333
117 A3D 0.401235 0.876543
118 DLL 0.4 0.864198
119 XAH 0.4 0.806818
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5FA6; Ligand: FAD; Similar sites found: 91
This union binding pocket(no: 1) in the query (biounit: 5fa6.bio1) has 70 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1LJ8 NAD 0.03851 0.40315 1.21704
2 3HQP FDP 0.01208 0.45397 1.40281
3 3RC3 ANP 0.04273 0.42697 1.61812
4 1X9I G6Q 0.03734 0.42327 1.65563
5 2OHH FMN 0.000479 0.49344 1.73267
6 4EI7 GDP 0.02052 0.41372 1.77994
7 3TDC 0EU 0.03166 0.41237 1.94175
8 1E5D FMN 0.0008923 0.47709 1.99005
9 3B5J 12D 0.04287 0.4307 2.05761
10 4IP7 FBP 0.02955 0.42233 2.20994
11 4PPF FLC 0.01924 0.45095 2.28571
12 4AMV F6R 0.03259 0.4201 2.29885
13 1J78 OLA 0.01266 0.45785 2.40175
14 4GLW NMN 0.0463 0.41588 2.62295
15 4D86 ADP 0.0269 0.41578 2.75081
16 3MQ2 SAH 0.03576 0.41506 2.75229
17 2BZZ AP5 0.03803 0.40832 2.96296
18 1G6H ADP 0.03226 0.44092 3.11284
19 4YRY NAD 0.000002864 0.50679 3.26087
20 1BO4 COA 0.02404 0.43737 3.57143
21 3LN9 FLC 0.0006029 0.54625 3.59712
22 4B2D FBP 0.02277 0.42826 3.64964
23 1KZL CRM 0.02157 0.43999 3.84615
24 3KL3 GCU 0.01469 0.41497 4.2394
25 2P3I MNA 0.02331 0.42053 4.96894
26 3CRZ NAP 0.00000000618 0.64283 5.05837
27 3CRZ FAD 0.000008312 0.58192 5.05837
28 4DS0 A2G GAL NAG FUC 0.04419 0.43519 5.52147
29 5E5U MLI 0.008699 0.44491 5.68182
30 3I7V B4P 0.0246 0.46292 5.97015
31 3OZV FAD 0.000698 0.43114 6.45161
32 2OYS FMN 0.03257 0.4091 6.61157
33 2BVE PH5 0.02166 0.42751 6.72269
34 2O2C G6Q 0.0193 0.43201 7.01468
35 2CXS F6P 0.03512 0.4075 7.18133
36 1RLJ FMN 0.000001782 0.63362 7.19424
37 1JJ7 ADP 0.04924 0.42735 7.30769
38 1PVC ILE SER GLU VAL 0.03204 0.42704 7.35294
39 5ITZ GDP 0.03371 0.40359 7.75194
40 5O0X FAD 0.0002349 0.54826 7.90378
41 4U9U FAD 0.0000005627 0.63806 8.8968
42 1T5B FMN 0.01092 0.4382 8.95522
43 5EOO CIT 0.03563 0.43642 9.0566
44 2JBM SRT 0.01376 0.43968 9.699
45 2VNI FAD 0.00000002766 0.6129 9.92647
46 2VNI A2P 0.00000002766 0.6129 9.92647
47 3N39 FMN 0.0002432 0.50329 10.9718
48 1T0I FMN 0.02733 0.41819 11.5183
49 2EIX FAD 0.0006587 0.46977 11.9342
50 1N13 AG2 0.04327 0.43123 12.3894
51 2QQC AG2 0.04916 0.42803 12.5
52 3GFS FMN 0.003701 0.47772 12.6437
53 2PIA FMN 0.0005697 0.49786 13.7072
54 2CND FAD 0.00001864 0.57044 15.9259
55 4N82 FMN 0.000004804 0.61178 16.2921
56 4R2I ANP 0.04186 0.43131 17.1429
57 1QX4 FAD 0.00003618 0.50301 18.2482
58 3JQQ A2P 0.0000006997 0.41012 25
59 2XNJ NAP 0.00002225 0.56669 26.3158
60 2XNJ FAD 0.0005202 0.47748 26.3158
61 2FCR FMN 0.0000001887 0.69123 27.1676
62 2WC1 FMN 0.000000004165 0.75772 29.6703
63 2RC5 FAD 0.00000009409 0.68267 30.2548
64 5NUL FMN 0.0001776 0.53228 30.4348
65 5K9B FMN 0.000000004772 0.75478 30.5556
66 5VW2 FDA 0.00000000008634 0.68646 31.962
67 5VW2 NAP 0.00000000008634 0.68646 31.962
68 1OBV FMN 0.00000001037 0.72947 34.9112
69 2BSA NAP 0.00000000447 0.58716 34.9835
70 2BSA FAD 0.000000006546 0.58547 34.9835
71 1EWY FAD 0.00000003797 0.73655 35.3135
72 1FND A2P 0.0000000001379 0.47875 35.6688
73 1FND FAD 0.0000000001379 0.47875 35.6688
74 1QFY FAD 0.00000000004649 0.49753 35.7143
75 1QFY NAP 0.00000000004649 0.49753 35.7143
76 1GAW FAD 0.0000000023 0.80077 36.3057
77 3VO1 FAD 0.00000000843 0.76101 36.9427
78 1SM4 FAD 0.00000001017 0.75681 37.5
79 3KAP FMN 0.00001034 0.57737 38.7755
80 2QTZ NAP 0.0000000000004496 0.81076 40.4453
81 2QTZ FAD 0.000000003963 0.76813 40.4453
82 1BVY FMN 0.000000001712 0.75886 44.5026
83 2XOD FMN 0.000001428 0.62495 44.5378
84 5LJI FMN 0.00001446 0.59381 44.5946
85 1AKV FMN 0.0000008778 0.6166 45.5782
86 4OXX FMN 0.00000000009197 0.84012 45.679
87 1F20 NAP 0.0000000005956 0.83172 48.5057
88 1F20 FAD 0.0000000001054 0.82684 48.5057
89 1TLL FMN 0.0000000005655 0.76463 49.1909
90 1TLL FAD 0.000000002798 0.75727 49.1909
91 1TLL NAP 0.00000003384 0.66884 49.1909
Pocket No.: 2; Query (leader) PDB : 5FA6; Ligand: FMN; Similar sites found: 91
This union binding pocket(no: 2) in the query (biounit: 5fa6.bio1) has 70 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1LJ8 NAD 0.03851 0.40315 1.21704
2 3HQP FDP 0.01208 0.45397 1.40281
3 3RC3 ANP 0.04273 0.42697 1.61812
4 1X9I G6Q 0.03734 0.42327 1.65563
5 2OHH FMN 0.000479 0.49344 1.73267
6 4EI7 GDP 0.02052 0.41372 1.77994
7 3TDC 0EU 0.03166 0.41237 1.94175
8 1E5D FMN 0.0008923 0.47709 1.99005
9 3B5J 12D 0.04287 0.4307 2.05761
10 4IP7 FBP 0.02955 0.42233 2.20994
11 4PPF FLC 0.01924 0.45095 2.28571
12 4AMV F6R 0.03259 0.4201 2.29885
13 1J78 OLA 0.01266 0.45785 2.40175
14 4GLW NMN 0.0463 0.41588 2.62295
15 4D86 ADP 0.0269 0.41578 2.75081
16 3MQ2 SAH 0.03576 0.41506 2.75229
17 2BZZ AP5 0.03803 0.40832 2.96296
18 1G6H ADP 0.03226 0.44092 3.11284
19 4YRY NAD 0.000002864 0.50679 3.26087
20 1BO4 COA 0.02404 0.43737 3.57143
21 3LN9 FLC 0.0006029 0.54625 3.59712
22 4B2D FBP 0.02277 0.42826 3.64964
23 1KZL CRM 0.02157 0.43999 3.84615
24 3KL3 GCU 0.01469 0.41497 4.2394
25 2P3I MNA 0.02331 0.42053 4.96894
26 3CRZ NAP 0.00000000618 0.64283 5.05837
27 3CRZ FAD 0.000008312 0.58192 5.05837
28 4DS0 A2G GAL NAG FUC 0.04419 0.43519 5.52147
29 5E5U MLI 0.008699 0.44491 5.68182
30 3I7V B4P 0.0246 0.46292 5.97015
31 3OZV FAD 0.000698 0.43114 6.45161
32 2OYS FMN 0.03257 0.4091 6.61157
33 2BVE PH5 0.02166 0.42751 6.72269
34 2O2C G6Q 0.0193 0.43201 7.01468
35 2CXS F6P 0.03512 0.4075 7.18133
36 1RLJ FMN 0.000001782 0.63362 7.19424
37 1JJ7 ADP 0.04924 0.42735 7.30769
38 1PVC ILE SER GLU VAL 0.03204 0.42704 7.35294
39 5ITZ GDP 0.03371 0.40359 7.75194
40 5O0X FAD 0.0002349 0.54826 7.90378
41 4U9U FAD 0.0000005627 0.63806 8.8968
42 1T5B FMN 0.01092 0.4382 8.95522
43 5EOO CIT 0.03563 0.43642 9.0566
44 2JBM SRT 0.01376 0.43968 9.699
45 2VNI FAD 0.00000002766 0.6129 9.92647
46 2VNI A2P 0.00000002766 0.6129 9.92647
47 3N39 FMN 0.0002432 0.50329 10.9718
48 1T0I FMN 0.02733 0.41819 11.5183
49 2EIX FAD 0.0006587 0.46977 11.9342
50 1N13 AG2 0.04327 0.43123 12.3894
51 2QQC AG2 0.04916 0.42803 12.5
52 3GFS FMN 0.003701 0.47772 12.6437
53 2PIA FMN 0.0005697 0.49786 13.7072
54 2CND FAD 0.00001864 0.57044 15.9259
55 4N82 FMN 0.000004804 0.61178 16.2921
56 4R2I ANP 0.04186 0.43131 17.1429
57 1QX4 FAD 0.00003618 0.50301 18.2482
58 3JQQ A2P 0.0000006997 0.41012 25
59 2XNJ NAP 0.00002225 0.56669 26.3158
60 2XNJ FAD 0.0005202 0.47748 26.3158
61 2FCR FMN 0.0000001887 0.69123 27.1676
62 2WC1 FMN 0.000000004165 0.75772 29.6703
63 2RC5 FAD 0.00000009409 0.68267 30.2548
64 5NUL FMN 0.0001776 0.53228 30.4348
65 5K9B FMN 0.000000004772 0.75478 30.5556
66 5VW2 FDA 0.00000000008634 0.68646 31.962
67 5VW2 NAP 0.00000000008634 0.68646 31.962
68 1OBV FMN 0.00000001037 0.72947 34.9112
69 2BSA NAP 0.00000000447 0.58716 34.9835
70 2BSA FAD 0.000000006546 0.58547 34.9835
71 1EWY FAD 0.00000003797 0.73655 35.3135
72 1FND A2P 0.0000000001379 0.47875 35.6688
73 1FND FAD 0.0000000001379 0.47875 35.6688
74 1QFY FAD 0.00000000004649 0.49753 35.7143
75 1QFY NAP 0.00000000004649 0.49753 35.7143
76 1GAW FAD 0.0000000023 0.80077 36.3057
77 3VO1 FAD 0.00000000843 0.76101 36.9427
78 1SM4 FAD 0.00000001017 0.75681 37.5
79 3KAP FMN 0.00001034 0.57737 38.7755
80 2QTZ NAP 0.0000000000004496 0.81076 40.4453
81 2QTZ FAD 0.000000003963 0.76813 40.4453
82 1BVY FMN 0.000000001712 0.75886 44.5026
83 2XOD FMN 0.000001428 0.62495 44.5378
84 5LJI FMN 0.00001446 0.59381 44.5946
85 1AKV FMN 0.0000008778 0.6166 45.5782
86 4OXX FMN 0.00000000009197 0.84012 45.679
87 1F20 NAP 0.0000000005956 0.83172 48.5057
88 1F20 FAD 0.0000000001054 0.82684 48.5057
89 1TLL FMN 0.0000000005655 0.76463 49.1909
90 1TLL FAD 0.000000002798 0.75727 49.1909
91 1TLL NAP 0.00000003384 0.66884 49.1909
Pocket No.: 3; Query (leader) PDB : 5FA6; Ligand: NAP; Similar sites found: 89
This union binding pocket(no: 3) in the query (biounit: 5fa6.bio1) has 71 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1LJ8 NAD 0.03947 0.40315 1.21704
2 3HQP FDP 0.01236 0.45397 1.40281
3 3RC3 ANP 0.04361 0.42697 1.61812
4 1X9I G6Q 0.03815 0.42327 1.65563
5 2OHH FMN 0.000495 0.49344 1.73267
6 4EI7 GDP 0.02107 0.41372 1.77994
7 3TDC 0EU 0.03217 0.41237 1.94175
8 1E5D FMN 0.0009215 0.47709 1.99005
9 3B5J 12D 0.04373 0.4307 2.05761
10 4IP7 FBP 0.03024 0.42233 2.20994
11 4PPF FLC 0.01961 0.45095 2.28571
12 4AMV F6R 0.03334 0.4201 2.29885
13 1J78 OLA 0.01291 0.45785 2.40175
14 4AZT SAM 0.0275 0.41858 2.589
15 4GLW NMN 0.0471 0.41588 2.62295
16 4D86 ADP 0.02633 0.41677 2.75081
17 2BZZ AP5 0.03894 0.40832 2.96296
18 1G6H ADP 0.03288 0.44092 3.11284
19 4YRY NAD 0.00000163 0.51603 3.26087
20 1BO4 COA 0.02457 0.43737 3.57143
21 3LN9 FLC 0.0006165 0.54625 3.59712
22 4B2D FBP 0.02331 0.42826 3.64964
23 1KZL CRM 0.02205 0.43999 3.84615
24 3KL3 GCU 0.01494 0.41497 4.2394
25 2P3I MNA 0.02374 0.42053 4.96894
26 3CRZ NAP 0.000000006587 0.64283 5.05837
27 3CRZ FAD 0.000008645 0.58192 5.05837
28 4DS0 A2G GAL NAG FUC 0.04497 0.43519 5.52147
29 5E5U MLI 0.00886 0.44491 5.68182
30 3I7V B4P 0.02501 0.46292 5.97015
31 3OZV FAD 0.0007284 0.43114 6.45161
32 2OYS FMN 0.03338 0.4091 6.61157
33 2BVE PH5 0.02205 0.42751 6.72269
34 2O2C G6Q 0.01976 0.43201 7.01468
35 2CXS F6P 0.03599 0.4075 7.18133
36 1RLJ FMN 0.000001854 0.63362 7.19424
37 1PVC ILE SER GLU VAL 0.0326 0.42704 7.35294
38 5O0X FAD 0.0002419 0.54826 7.90378
39 4U9U FAD 0.0000005849 0.63817 8.8968
40 1T5B FMN 0.0112 0.4382 8.95522
41 5EOO CIT 0.03631 0.43642 9.0566
42 2JBM SRT 0.01403 0.43968 9.699
43 2VNI FAD 0.00000002942 0.6129 9.92647
44 2VNI A2P 0.00000002942 0.6129 9.92647
45 3N39 FMN 0.0002518 0.50329 10.9718
46 1T0I FMN 0.02799 0.41819 11.5183
47 2EIX FAD 0.0006822 0.46977 11.9342
48 1N13 AG2 0.04412 0.43123 12.3894
49 2QQC AG2 0.04636 0.42921 12.5
50 3GFS FMN 0.003797 0.47772 12.6437
51 2PIA FMN 0.0005879 0.49786 13.7072
52 2CND FAD 0.00001934 0.57044 15.9259
53 4N82 FMN 0.00000499 0.61178 16.2921
54 4R2I ANP 0.04271 0.43131 17.1429
55 1QX4 FAD 0.00003782 0.50301 18.2482
56 3JQQ A2P 0.0000007373 0.40747 25
57 2XNJ NAP 0.00002308 0.56669 26.3158
58 2XNJ FAD 0.0005387 0.47748 26.3158
59 2FCR FMN 0.0000001969 0.69123 27.1676
60 2WC1 FMN 0.00000000438 0.75772 29.6703
61 2RC5 FAD 0.00000009854 0.68267 30.2548
62 5NUL FMN 0.0001834 0.53228 30.4348
63 5K9B FMN 0.000000005018 0.75478 30.5556
64 5VW2 FDA 0.00000000009333 0.68646 31.962
65 5VW2 NAP 0.00000000009333 0.68646 31.962
66 1OBV FMN 0.0000000109 0.72947 34.9112
67 2BSA NAP 0.000000004827 0.58716 34.9835
68 2BSA FAD 0.000000007055 0.58547 34.9835
69 1EWY FAD 0.00000003969 0.73655 35.3135
70 1FND A2P 0.0000000001479 0.475 35.6688
71 1FND FAD 0.0000000001479 0.475 35.6688
72 1QFY NAP 0.00000000005007 0.49354 35.7143
73 1QFY FAD 0.00000000005007 0.49354 35.7143
74 1GAW FAD 0.000000002415 0.80077 36.3057
75 3VO1 FAD 0.00000000884 0.76101 36.9427
76 1SM4 FAD 0.00000001066 0.75681 37.5
77 3KAP FMN 0.00001075 0.57737 38.7755
78 2QTZ NAP 0.0000000000004885 0.81076 40.4453
79 2QTZ FAD 0.000000004165 0.76813 40.4453
80 1BVY FMN 0.000000001807 0.75886 44.5026
81 2XOD FMN 0.000001489 0.62495 44.5378
82 5LJI FMN 0.00001498 0.59381 44.5946
83 1AKV FMN 0.0000009178 0.6166 45.5782
84 4OXX FMN 0.00000000009735 0.84012 45.679
85 1F20 NAP 0.0000000006266 0.83172 48.5057
86 1F20 FAD 0.0000000001117 0.82684 48.5057
87 1TLL FMN 0.0000000005991 0.76463 49.1909
88 1TLL FAD 0.000000002947 0.75727 49.1909
89 1TLL NAP 0.00000003565 0.66884 49.1909
Pocket No.: 4; Query (leader) PDB : 5FA6; Ligand: FAD; Similar sites found: 18
This union binding pocket(no: 4) in the query (biounit: 5fa6.bio2) has 71 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4AFK FLC 0.02828 0.41548 1.52838
2 2POC BG6 0.01568 0.44071 1.63488
3 4AZT SAM 0.04526 0.4076 2.589
4 2WPX ACO 0.04891 0.40588 2.65487
5 1MZC SUC 0.02153 0.44453 2.91262
6 2FN1 SAL 0.03981 0.42925 3.43249
7 5DUS APR 0.0421 0.4018 3.57143
8 5LAU AR6 0.02294 0.40961 3.84615
9 2WZF BGC 0.04159 0.43104 4.19048
10 1KQR MNA 0.01165 0.44122 4.46927
11 3M89 GSP 0.02637 0.43206 4.68384
12 4K91 SIN 0.04761 0.41132 5.78035
13 4IF4 BEF 0.04976 0.42515 6.25
14 2Z48 A2G 0.04658 0.42251 6.94444
15 3JU6 ARG 0.03685 0.43279 7.02703
16 4ONT SIA GAL BGC 0.03717 0.43267 9.30233
17 4V3I ASP LEU THR ARG PRO 0.04662 0.42954 9.72763
18 4J5R A1R 0.03037 0.40625 13.6986
Pocket No.: 5; Query (leader) PDB : 5FA6; Ligand: NAP; Similar sites found: 20
This union binding pocket(no: 5) in the query (biounit: 5fa6.bio2) has 72 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4AFK FLC 0.02878 0.41548 1.52838
2 2POC BG6 0.01605 0.44071 1.63488
3 2WPX ACO 0.0473 0.40712 2.65487
4 3MQ2 SAH 0.04649 0.41017 2.75229
5 1MZC SUC 0.02199 0.44453 2.91262
6 5UDS ATP 0.04488 0.42321 3.14685
7 2FN1 SAL 0.04062 0.42925 3.43249
8 5DUS APR 0.04312 0.4018 3.57143
9 5LAU AR6 0.02355 0.40961 3.84615
10 2WZF BGC 0.0424 0.43104 4.19048
11 3S6X SIA GAL BGC 0.03603 0.42859 4.30769
12 1KQR MNA 0.01187 0.44122 4.46927
13 3M89 GSP 0.02696 0.43206 4.68384
14 4K91 SIN 0.04842 0.41132 5.78035
15 2Z48 A2G 0.0474 0.42251 6.94444
16 3JU6 ARG 0.03754 0.43279 7.02703
17 5ITZ GDP 0.0178 0.4177 7.75194
18 4ONT SIA GAL BGC 0.03788 0.43267 9.30233
19 4V3I ASP LEU THR ARG PRO 0.04749 0.42954 9.72763
20 4J5R A1R 0.03114 0.40625 13.6986
Pocket No.: 6; Query (leader) PDB : 5FA6; Ligand: FMN; Similar sites found: 13
This union binding pocket(no: 6) in the query (biounit: 5fa6.bio2) has 70 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4AFK FLC 0.02777 0.41548 1.52838
2 2POC BG6 0.01531 0.44071 1.63488
3 4AZT SAM 0.04423 0.4076 2.589
4 1MZC SUC 0.02106 0.44453 2.91262
5 2FN1 SAL 0.039 0.42925 3.43249
6 5LAU AR6 0.02751 0.40543 3.84615
7 2WZF BGC 0.04079 0.43104 4.19048
8 1KQR MNA 0.01142 0.44122 4.46927
9 4K91 SIN 0.04679 0.41132 5.78035
10 4IF4 BEF 0.04888 0.42515 6.25
11 2Z48 A2G 0.04576 0.42251 6.94444
12 3JU6 ARG 0.03617 0.43279 7.02703
13 4ONT SIA GAL BGC 0.03646 0.43267 9.30233
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