-->
Receptor
PDB id Resolution Class Description Source Keywords
4YAL 1.88 Å EC: 1.6.2.4 REDUCED CYPOR WITH 2'-AMP RATTUS NORVEGICUS CYTOCHROME P450 REDUCTASE FMN BINDING SEMIQUINONE OXIDORE
Ref.: MUTANTS OF CYTOCHROME P450 REDUCTASE LACKING EITHER OR GLY-143 DESTABILIZE ITS FMN SEMIQUINONE. J.BIOL.CHEM. V. 291 14639 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PO4 A:704;
B:704;
A:705;
B:705;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
94.971 O4 P [O-]P...
2AM B:703;
A:703;
Valid;
Valid;
none;
none;
submit data
347.221 C10 H14 N5 O7 P c1nc(...
FMN A:701;
B:701;
Valid;
Valid;
none;
none;
submit data
456.344 C17 H21 N4 O9 P Cc1cc...
FAD A:702;
B:702;
Valid;
Valid;
none;
none;
submit data
785.55 C27 H33 N9 O15 P2 Cc1cc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5FA6 2.3 Å EC: 1.6.2.4 WILD TYPE HUMAN CYPOR HOMO SAPIENS CYPOR CYTOCHROME P450 REDUCTASE FLAVOPROTEIN ABS-LIKE PHEOXIDOREDUCTASE
Ref.: INSTABILITY OF THE HUMAN CYTOCHROME P450 REDUCTASE VARIANT IS THE MAJOR CONTRIBUTOR TO ITS ANTLEY-BIXL SYNDROME-LIKE PHENOTYPE. J.BIOL.CHEM. V. 291 20487 2016
Members (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 3QFC - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 4YAF - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
3 3OJX - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 4Y9U - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
5 4Y9R - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
6 4YAL - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
7 4YAW - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
8 3OJW - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 5FA6 Ki = 16.1 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 4YAO - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
11 4YAU - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
12 4Y7C - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
13 3QFR - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
14 5EMN - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 1JA1 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
16 3QE2 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
70% Homology Family (19)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3QFC - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 4YAF - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
3 3OJX - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 4Y9U - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
5 4Y9R - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
6 4YAL - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
7 4YAW - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
8 3OJW - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 5FA6 Ki = 16.1 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 4YAO - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
11 4YAU - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
12 4Y7C - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
13 3QFR - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
14 5EMN - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 1JA1 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
16 3QE2 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
17 3FJO - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
18 3QFT - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
19 3QFS - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
50% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 3QFC - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 4YAF - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
3 3OJX - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 4Y9U - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
5 4Y9R - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
6 4YAL - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
7 4YAW - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
8 3OJW - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 5FA6 Ki = 16.1 uM NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
10 4YAO - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
11 4YAU - 2AM C10 H14 N5 O7 P c1nc(c2c(n....
12 4Y7C - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
13 3QFR - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
14 5EMN - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
15 1JA1 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
16 3QE2 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
17 3FJO - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
18 3QFT - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
19 3QFS - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
20 5GXU - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 2AM; Similar ligands found: 249
No: Ligand ECFP6 Tc MDL keys Tc
1 2AM 1 1
2 OVE 0.828125 0.957747
3 A2P 0.80597 0.956522
4 ATR 0.739726 0.971014
5 3AM 0.691176 0.956522
6 A2R 0.683544 0.930556
7 A22 0.675 0.930556
8 NA7 0.642857 0.905405
9 A3P 0.635135 0.942857
10 XYA 0.6 0.842857
11 ADN 0.6 0.842857
12 RAB 0.6 0.842857
13 7D5 0.591549 0.902778
14 A 0.589041 0.942857
15 AMP 0.589041 0.942857
16 25A 0.588235 0.916667
17 PAP 0.5875 0.957143
18 V3L 0.573171 0.916667
19 PPS 0.566265 0.848101
20 7D7 0.560606 0.763889
21 25L 0.549451 0.930556
22 ABM 0.545455 0.890411
23 A2D 0.545455 0.916667
24 ADP 0.544304 0.943662
25 101 0.539474 0.902778
26 SRA 0.539474 0.891892
27 7D3 0.538462 0.90411
28 AN2 0.5375 0.930556
29 2A5 0.536585 0.917808
30 5N5 0.536232 0.816901
31 PO4 PO4 A A A A PO4 0.533333 0.901408
32 AP2 0.531646 0.905405
33 BA3 0.531646 0.916667
34 A12 0.531646 0.905405
35 SAP 0.53012 0.893333
36 AGS 0.53012 0.893333
37 NPW 0.529412 0.8375
38 NDP 0.529412 0.87013
39 5CD 0.528571 0.777778
40 A4D 0.528571 0.816901
41 LMS 0.526316 0.780488
42 AP5 0.525 0.916667
43 B4P 0.525 0.916667
44 HEJ 0.52439 0.943662
45 ATP 0.52439 0.943662
46 TXP 0.524272 0.87013
47 NZQ 0.524272 0.858974
48 ODP 0.519231 0.858974
49 NJP 0.519231 0.893333
50 AT4 0.518519 0.905405
51 SON 0.518519 0.88
52 APC 0.518072 0.905405
53 AQP 0.518072 0.943662
54 5FA 0.518072 0.943662
55 XNP 0.514286 0.848101
56 M33 0.512195 0.90411
57 CA0 0.512195 0.891892
58 7D4 0.512195 0.90411
59 ADX 0.512195 0.825
60 AU1 0.512195 0.917808
61 EP4 0.506849 0.727273
62 50T 0.506024 0.930556
63 ACP 0.506024 0.917808
64 M2T 0.5 0.708861
65 AR6 0.5 0.916667
66 PRX 0.5 0.866667
67 DTA 0.5 0.76
68 TAT 0.5 0.905405
69 5AD 0.5 0.742857
70 T99 0.5 0.905405
71 APR 0.5 0.916667
72 ACQ 0.5 0.917808
73 ADQ 0.494505 0.917808
74 RBY 0.494118 0.88
75 ADV 0.494118 0.88
76 AD9 0.494118 0.917808
77 A3G 0.493671 0.797297
78 MTA 0.493333 0.746667
79 Y3J 0.492958 0.722222
80 ATF 0.488636 0.905405
81 AV2 0.488636 0.916667
82 2VA 0.488095 0.797297
83 2GP 0.487805 0.905405
84 QQY 0.487179 0.863014
85 ACK 0.487179 0.913043
86 103 0.487179 0.835616
87 3AD 0.486111 0.828571
88 OAD 0.483871 0.891892
89 9X8 0.483871 0.868421
90 6YZ 0.483146 0.917808
91 ANP 0.482759 0.917808
92 6RE 0.481013 0.75641
93 3DH 0.480519 0.746667
94 NAP 0.477876 0.891892
95 5AL 0.477273 0.878378
96 ADP PO3 0.476744 0.888889
97 NVA 2AD 0.476744 0.75641
98 NEC 0.475 0.767123
99 D5M 0.475 0.902778
100 DA 0.475 0.902778
101 AOC 0.475 0.794521
102 QQX 0.474359 0.851351
103 DG1 0.473684 0.87013
104 TAP 0.473684 0.857143
105 1DG 0.473684 0.87013
106 CC5 0.471429 0.788732
107 SO8 0.471264 0.786667
108 VRT 0.471264 0.766234
109 5X8 0.470588 0.736842
110 5AS 0.46988 0.755814
111 7L1 0.469565 0.772727
112 NA0 0.469565 0.88
113 ZAS 0.468354 0.74026
114 ADP BMA 0.468085 0.891892
115 9ZA 0.467391 0.857143
116 5SV 0.467391 0.822785
117 9ZD 0.467391 0.857143
118 SRP 0.466667 0.88
119 GAP 0.465909 0.866667
120 3AT 0.465909 0.943662
121 3D1 0.465753 0.794521
122 3L1 0.465753 0.794521
123 A3S 0.464286 0.808219
124 S4M 0.463415 0.662791
125 MAO 0.457831 0.73494
126 00A 0.457447 0.833333
127 DSH 0.45679 0.721519
128 MAP 0.456522 0.893333
129 ADP ALF 0.455556 0.820513
130 ALF ADP 0.455556 0.820513
131 A3T 0.453488 0.819444
132 SFG 0.453488 0.723684
133 DAT 0.453488 0.90411
134 APU 0.45283 0.893333
135 A A A 0.452632 0.853333
136 8QN 0.451613 0.878378
137 OOB 0.451613 0.878378
138 J7C 0.451219 0.766234
139 A3N 0.451219 0.783784
140 ADP VO4 0.450549 0.878378
141 VO4 ADP 0.450549 0.878378
142 A A 0.447917 0.916667
143 PR8 0.447917 0.825
144 4AD 0.446809 0.868421
145 A3R 0.446809 0.881579
146 A1R 0.446809 0.881579
147 AMO 0.446809 0.88
148 PAJ 0.446809 0.858974
149 GJV 0.445783 0.746835
150 0WD 0.445455 0.87013
151 NMN AMP PO4 0.445455 0.820513
152 UPA 0.443396 0.881579
153 BIS 0.443299 0.881579
154 FYA 0.443299 0.878378
155 3OD 0.443299 0.891892
156 PTJ 0.443299 0.846154
157 1ZZ 0.443299 0.792683
158 A5D 0.443182 0.76
159 SA8 0.443182 0.682927
160 DLL 0.442105 0.878378
161 AHX 0.442105 0.87013
162 AR6 AR6 0.441176 0.864865
163 DAL AMP 0.44086 0.853333
164 GGZ 0.44086 0.822785
165 CO7 0.439024 0.781609
166 TM1 0.438776 0.771084
167 G5A 0.438202 0.755814
168 SAH 0.438202 0.717949
169 SAI 0.438202 0.708861
170 3UK 0.4375 0.866667
171 SMM 0.434783 0.662791
172 S7M 0.434783 0.666667
173 9SN 0.434343 0.822785
174 5F1 0.434211 0.72973
175 OMR 0.433962 0.804878
176 AS 0.433735 0.855263
177 DTP 0.433333 0.90411
178 LAD 0.43299 0.835443
179 WAQ 0.43299 0.833333
180 B5V 0.43299 0.855263
181 RP1 0.432099 0.84
182 SP1 0.432099 0.84
183 A7D 0.430233 0.773333
184 ATP A A A 0.43 0.876712
185 TXA 0.428571 0.88
186 NB8 0.428571 0.846154
187 ME8 0.428571 0.792683
188 JB6 0.428571 0.833333
189 EEM 0.428571 0.666667
190 TSB 0.425532 0.77381
191 MHZ 0.425287 0.694118
192 MYR AMP 0.424242 0.771084
193 A5A 0.423913 0.761905
194 CMP 0.423529 0.9
195 2BA 0.423529 0.887324
196 ENP 0.42268 0.866667
197 ARJ 0.421053 0.746479
198 GEK 0.421053 0.691358
199 N01 0.421053 0.853333
200 SSA 0.419355 0.776471
201 NOC 0.418919 0.760563
202 P5A 0.418367 0.722222
203 SAM 0.417582 0.666667
204 DDS 0.417582 0.876712
205 FA5 0.415842 0.855263
206 YAP 0.415842 0.844156
207 B5M 0.415842 0.844156
208 B5Y 0.415842 0.844156
209 54H 0.414894 0.744186
210 52H 0.414894 0.735632
211 VMS 0.414894 0.744186
212 AFH 0.413462 0.858974
213 ANZ 0.413462 0.820513
214 AAT 0.413043 0.703704
215 A U 0.412844 0.844156
216 XAH 0.411765 0.814815
217 NAI 0.411215 0.857143
218 ZDA 0.411111 0.837838
219 8X1 0.410526 0.730337
220 D3Y 0.410526 0.786667
221 53H 0.410526 0.735632
222 5CA 0.410526 0.776471
223 5J9 0.41 0.728395
224 A6D 0.408163 0.698795
225 K15 0.408163 0.658824
226 TYR AMP 0.407767 0.820513
227 4UV 0.407767 0.844156
228 V1N 0.407767 0.890411
229 LAQ 0.40566 0.792683
230 DCA 0.405172 0.8
231 ETB 0.405172 0.809524
232 3NZ 0.40404 0.779221
233 G3A 0.403846 0.87013
234 AP0 0.40367 0.846154
235 5HG 0.402597 0.723684
236 AFX 0.402597 0.675325
237 NSS 0.402062 0.755814
238 0UM 0.402062 0.695122
239 DSZ 0.402062 0.755814
240 LSS 0.402062 0.719101
241 48N 0.401869 0.846154
242 PUA 0.401709 0.858974
243 0XU 0.4 0.701299
244 7MD 0.4 0.8375
245 9K8 0.4 0.673913
246 G5P 0.4 0.87013
247 ARG AMP 0.4 0.804878
248 GA7 0.4 0.905405
249 4UU 0.4 0.844156
Ligand no: 2; Ligand: FMN; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 FMN 1 1
2 RBF 0.75641 0.876712
3 RS3 0.571429 0.831169
4 FAD 0.543307 0.876543
5 FAS 0.543307 0.876543
6 FAE 0.539062 0.865854
7 LFN 0.475 0.643836
8 C3F 0.473684 0.74359
9 CF4 0.463918 0.734177
10 FAY 0.446043 0.864198
11 FNR 0.444444 0.909091
12 RFL 0.442857 0.845238
13 4LS 0.411215 0.875
14 1VY 0.406593 0.769231
15 DLZ 0.404494 0.782051
Ligand no: 3; Ligand: FAD; Similar ligands found: 128
No: Ligand ECFP6 Tc MDL keys Tc
1 FAD 1 1
2 FAS 1 1
3 FAY 0.859259 0.9875
4 RFL 0.852941 0.963855
5 6FA 0.794118 0.987654
6 FAE 0.751773 0.987654
7 SFD 0.651007 0.860215
8 FDA 0.641892 0.906977
9 FNK 0.602564 0.876405
10 62F 0.572327 0.939024
11 F2N 0.566265 0.886364
12 FMN 0.543307 0.876543
13 FA9 0.526316 0.939759
14 6YU 0.516304 0.860215
15 P6G FDA 0.511628 0.908046
16 FAD NBT 0.508876 0.83871
17 A2D 0.504065 0.875
18 P5F 0.491329 0.941176
19 FAD CNX 0.488506 0.8125
20 AR6 0.488372 0.851852
21 APR 0.488372 0.851852
22 AGS 0.484615 0.811765
23 SAP 0.484615 0.811765
24 M33 0.484375 0.864198
25 BA3 0.484127 0.875
26 HEJ 0.48062 0.851852
27 ATP 0.48062 0.851852
28 ADP 0.480315 0.851852
29 B4P 0.480315 0.875
30 AP5 0.480315 0.875
31 ANP 0.477273 0.831325
32 AQP 0.476923 0.851852
33 5FA 0.476923 0.851852
34 48N 0.469388 0.902439
35 OAD 0.467626 0.876543
36 9X8 0.467626 0.833333
37 FAD NBA 0.467033 0.793814
38 GTA 0.465753 0.892857
39 AN2 0.465116 0.841463
40 AT4 0.465116 0.821429
41 AD9 0.462121 0.831325
42 3OD 0.460993 0.876543
43 RBF 0.460938 0.790123
44 FB0 0.460606 0.835165
45 139 0.460526 0.858824
46 AP0 0.46 0.835294
47 A22 0.459854 0.864198
48 ACP 0.458015 0.853659
49 8QN 0.456522 0.864198
50 PRX 0.454545 0.831325
51 A3R 0.453237 0.86747
52 A1R 0.453237 0.86747
53 G3A 0.452055 0.902439
54 T5A 0.45098 0.872093
55 G5P 0.44898 0.902439
56 ATF 0.448529 0.821429
57 50T 0.44697 0.819277
58 6YZ 0.445255 0.853659
59 ACQ 0.444444 0.853659
60 CNV FAD 0.443182 0.917647
61 ADQ 0.442857 0.853659
62 PAJ 0.442857 0.847059
63 5AL 0.441176 0.864198
64 ADX 0.439394 0.775281
65 CA0 0.439394 0.853659
66 A4P 0.437909 0.831461
67 25L 0.4375 0.864198
68 P33 FDA 0.436464 0.817204
69 5SV 0.435714 0.793103
70 OMR 0.434211 0.818182
71 TXE 0.434211 0.890244
72 ABM 0.434109 0.829268
73 A 0.433071 0.82716
74 AMP 0.433071 0.82716
75 4AD 0.432624 0.855422
76 ADJ 0.432258 0.818182
77 B5M 0.431507 0.878049
78 B5Y 0.431507 0.878049
79 BIS 0.430556 0.802326
80 SRA 0.429688 0.788235
81 AFH 0.42953 0.825581
82 NXX 0.427632 0.865854
83 DND 0.427632 0.865854
84 UP5 0.427632 0.878049
85 6V0 0.427632 0.857143
86 TXD 0.427632 0.890244
87 DQV 0.426667 0.8875
88 SRP 0.42446 0.843373
89 PR8 0.423611 0.837209
90 T99 0.423358 0.821429
91 TAT 0.423358 0.821429
92 AMO 0.422535 0.865854
93 TXA 0.42069 0.865854
94 FYA 0.42069 0.864198
95 PTJ 0.42069 0.835294
96 CNA 0.420382 0.865854
97 00A 0.41958 0.823529
98 AHX 0.41958 0.835294
99 MAP 0.41844 0.811765
100 NAI 0.418301 0.845238
101 AU1 0.41791 0.831325
102 A12 0.416667 0.843373
103 AP2 0.416667 0.843373
104 25A 0.415493 0.851852
105 9ZA 0.415493 0.845238
106 9ZD 0.415493 0.845238
107 COD 0.415094 0.842697
108 4TC 0.412903 0.879518
109 APC 0.411765 0.843373
110 ME8 0.410959 0.806818
111 1ZZ 0.410959 0.806818
112 NB8 0.410959 0.835294
113 4UW 0.409091 0.825581
114 NAX 0.409091 0.837209
115 F2R 0.408805 0.850575
116 RBY 0.408759 0.843373
117 ADV 0.408759 0.843373
118 P1H 0.405882 0.818182
119 OOB 0.405594 0.864198
120 LAD 0.40411 0.825581
121 A A 0.40411 0.829268
122 UPA 0.403846 0.86747
123 4UU 0.401316 0.833333
124 GA7 0.401316 0.865854
125 A3D 0.401235 0.876543
126 80F 0.401235 0.808989
127 XAH 0.4 0.806818
128 DLL 0.4 0.864198
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5FA6; Ligand: FAD; Similar sites found with APoc: 156
This union binding pocket(no: 1) in the query (biounit: 5fa6.bio1) has 70 residues
No: Leader PDB Ligand Sequence Similarity
1 1FUR MLT 1.07066
2 4KCT FDP 1.2024
3 1LJ8 NAD 1.21704
4 3HQP FDP 1.40281
5 3RC3 ANP 1.61812
6 2POC BG6 1.63488
7 1X9I G6Q 1.65563
8 2OHH FMN 1.73267
9 1E5D FMN 1.99005
10 3B5J 12D 2.05761
11 3VPD CIT 2.13523
12 4IP7 FBP 2.20994
13 4PPF FLC 2.28571
14 4AMV F6R 2.29885
15 1J78 OLA 2.40175
16 6FRN FMN 2.43902
17 5HV7 RBL 2.52294
18 4YHB FAD 2.5641
19 4GLW NMN 2.62295
20 4D86 ADP 2.75081
21 6BYF CIT 2.94118
22 4C0X FMN 2.95567
23 2BZZ AP5 2.96296
24 3S2Y FMN 3.01508
25 1G6H ADP 3.11284
26 2AWN ADP 3.14961
27 4YRY FAD 3.26087
28 4YRY NAD 3.26087
29 5JCA FAD 3.39806
30 1I36 NAP 3.40909
31 4G1V FAD 3.50877
32 1BO4 COA 3.57143
33 3LN9 FLC 3.59712
34 4B2D FBP 3.64964
35 1KZL CRM 3.84615
36 4LO6 SIA GAL 4.21053
37 1EP2 FAD 4.21456
38 3KL3 GCU 4.2394
39 5MJI 7O6 4.28016
40 5CEO 50D 4.33333
41 2Z9C FMN 4.5
42 2Z9C DTC 4.5
43 4R81 FMN 4.85437
44 2Y65 ADP 4.93151
45 2P3I MNA 4.96894
46 1USF NAP 5.05618
47 3CRZ FAD 5.05837
48 3CRZ NAP 5.05837
49 5YLY FAD 5.13699
50 5NM7 GLY 5.26316
51 3ITJ CIT 5.32544
52 4B4D FAD 5.34351
53 4DS0 A2G GAL NAG FUC 5.52147
54 5E5U MLI 5.68182
55 4G6I RS3 5.71429
56 3I7V B4P 5.97015
57 5IFK HPA 6.08974
58 3IVV ASP GLU VAL THR SER THR THR SER SER SER 6.2069
59 6GEH FAD 6.25
60 4EOY ASN ASP TRP LEU LEU PRO SER TYR 6.25
61 3OZV FAD 6.45161
62 1KOJ PAN 6.4632
63 3KYF 5GP 5GP 6.49351
64 2FJK 13P 6.55738
65 2OYS FMN 6.61157
66 4WOH 4NP 6.62651
67 2BVE PH5 6.72269
68 2Q9U FMN 7.00483
69 2O2C G6Q 7.01468
70 1RJW ETF 7.07965
71 2CXS F6P 7.18133
72 1RLJ FMN 7.19424
73 1O5O U5P 7.23982
74 5WHT SIA GAL 7.24638
75 1JJ7 ADP 7.30769
76 1PVC ILE SER GLU VAL 7.35294
77 3A3B FMN 7.36842
78 5O0X FAD 7.90378
79 4UP4 GAL NAG 7.98005
80 3SVL FMN 8.29016
81 4U9U FAD 8.8968
82 1A8P FAD 8.91473
83 1T5B FMN 8.95522
84 5EOO CIT 9.0566
85 4ONT SIA GAL BGC 9.30233
86 2JBM SRT 9.699
87 2VNI A2P 9.92647
88 2VNI FAD 9.92647
89 4LTN FMN 10.1523
90 4LTN NAI 10.1523
91 2D2F ADP 10.8
92 3CQO FUC 10.9215
93 3N39 FMN 10.9718
94 4PTZ FMN 10.9948
95 2CHT TSA 11.0236
96 1T0I FMN 11.5183
97 2EIX FAD 11.9342
98 1N13 AG2 12.3894
99 2QQC AG2 12.5
100 3GFS FMN 12.6437
101 2PIA FMN 13.7072
102 1KRH FAD 14.497
103 4WQM FAD 15.6442
104 5LMC FMN 15.6576
105 2CND FAD 15.9259
106 5OGX FAD 16.0714
107 4N82 FMN 16.2921
108 4R2I ANP 17.1429
109 1QX4 FAD 18.2482
110 3W2E FAD 18.8192
111 3W2E NAD 18.8192
112 6EBQ FMN 23.125
113 3JQQ A2P 25
114 3JQQ FAD 25
115 2XNJ NAP 26.3158
116 2XNJ FAD 26.3158
117 2FCR FMN 27.1676
118 2WC1 FMN 29.6703
119 4BMO FMN 30.2521
120 2RC5 FAD 30.2548
121 5NUL FMN 30.4348
122 5K9B FMN 30.5556
123 5VEG FMN 31.4607
124 5VW2 NAP 31.962
125 5VW2 FDA 31.962
126 5H5J FAD 32.3625
127 1OBV FMN 34.9112
128 2BSA NAP 34.9835
129 2BSA FAD 34.9835
130 1EWY FAD 35.3135
131 1FND A2P 35.6688
132 1FND FAD 35.6688
133 1QFY FAD 35.7143
134 1QFY NAP 35.7143
135 1GAW FAD 36.3057
136 1AG9 FMN 36.5714
137 3VO1 FAD 36.9427
138 1SM4 FAD 37.5
139 3MHP FAD 37.5
140 1CZR FMN 37.8698
141 3KAP FMN 38.7755
142 2QTZ NAP 40.4453
143 2QTZ FAD 40.4453
144 6GAQ FMN 41.5584
145 6FSG FMN 42.1769
146 4HEQ FMN 43.1507
147 1BVY FMN 44.5026
148 5LJI FMN 44.5946
149 1AKV FMN 45.5782
150 4OXX FMN 45.679
151 3F6R FMN 45.9459
152 1F20 NAP 48.5057
153 1F20 FAD 48.5057
154 1TLL FAD 49.1909
155 1TLL FMN 49.1909
156 1TLL NAP 49.1909
Pocket No.: 2; Query (leader) PDB : 5FA6; Ligand: FMN; Similar sites found with APoc: 156
This union binding pocket(no: 2) in the query (biounit: 5fa6.bio1) has 70 residues
No: Leader PDB Ligand Sequence Similarity
1 1FUR MLT 1.07066
2 4KCT FDP 1.2024
3 1LJ8 NAD 1.21704
4 3HQP FDP 1.40281
5 3RC3 ANP 1.61812
6 2POC BG6 1.63488
7 1X9I G6Q 1.65563
8 2OHH FMN 1.73267
9 1E5D FMN 1.99005
10 3B5J 12D 2.05761
11 3VPD CIT 2.13523
12 4IP7 FBP 2.20994
13 4PPF FLC 2.28571
14 4AMV F6R 2.29885
15 1J78 OLA 2.40175
16 6FRN FMN 2.43902
17 5HV7 RBL 2.52294
18 4YHB FAD 2.5641
19 4GLW NMN 2.62295
20 4D86 ADP 2.75081
21 6BYF CIT 2.94118
22 4C0X FMN 2.95567
23 2BZZ AP5 2.96296
24 3S2Y FMN 3.01508
25 1G6H ADP 3.11284
26 2AWN ADP 3.14961
27 4YRY FAD 3.26087
28 4YRY NAD 3.26087
29 5JCA FAD 3.39806
30 1I36 NAP 3.40909
31 4G1V FAD 3.50877
32 1BO4 COA 3.57143
33 3LN9 FLC 3.59712
34 4B2D FBP 3.64964
35 1KZL CRM 3.84615
36 4LO6 SIA GAL 4.21053
37 1EP2 FAD 4.21456
38 3KL3 GCU 4.2394
39 5MJI 7O6 4.28016
40 5CEO 50D 4.33333
41 2Z9C FMN 4.5
42 2Z9C DTC 4.5
43 4R81 FMN 4.85437
44 2Y65 ADP 4.93151
45 2P3I MNA 4.96894
46 1USF NAP 5.05618
47 3CRZ FAD 5.05837
48 3CRZ NAP 5.05837
49 5YLY FAD 5.13699
50 5NM7 GLY 5.26316
51 3ITJ CIT 5.32544
52 4B4D FAD 5.34351
53 4DS0 A2G GAL NAG FUC 5.52147
54 5E5U MLI 5.68182
55 4G6I RS3 5.71429
56 3I7V B4P 5.97015
57 5IFK HPA 6.08974
58 3IVV ASP GLU VAL THR SER THR THR SER SER SER 6.2069
59 6GEH FAD 6.25
60 4EOY ASN ASP TRP LEU LEU PRO SER TYR 6.25
61 3OZV FAD 6.45161
62 1KOJ PAN 6.4632
63 3KYF 5GP 5GP 6.49351
64 2FJK 13P 6.55738
65 2OYS FMN 6.61157
66 4WOH 4NP 6.62651
67 2BVE PH5 6.72269
68 2Q9U FMN 7.00483
69 2O2C G6Q 7.01468
70 1RJW ETF 7.07965
71 2CXS F6P 7.18133
72 1RLJ FMN 7.19424
73 1O5O U5P 7.23982
74 5WHT SIA GAL 7.24638
75 1JJ7 ADP 7.30769
76 1PVC ILE SER GLU VAL 7.35294
77 3A3B FMN 7.36842
78 5O0X FAD 7.90378
79 4UP4 GAL NAG 7.98005
80 3SVL FMN 8.29016
81 4U9U FAD 8.8968
82 1A8P FAD 8.91473
83 1T5B FMN 8.95522
84 5EOO CIT 9.0566
85 4ONT SIA GAL BGC 9.30233
86 2JBM SRT 9.699
87 2VNI A2P 9.92647
88 2VNI FAD 9.92647
89 4LTN FMN 10.1523
90 4LTN NAI 10.1523
91 2D2F ADP 10.8
92 3CQO FUC 10.9215
93 3N39 FMN 10.9718
94 4PTZ FMN 10.9948
95 2CHT TSA 11.0236
96 1T0I FMN 11.5183
97 2EIX FAD 11.9342
98 1N13 AG2 12.3894
99 2QQC AG2 12.5
100 3GFS FMN 12.6437
101 2PIA FMN 13.7072
102 1KRH FAD 14.497
103 4WQM FAD 15.6442
104 5LMC FMN 15.6576
105 2CND FAD 15.9259
106 5OGX FAD 16.0714
107 4N82 FMN 16.2921
108 4R2I ANP 17.1429
109 1QX4 FAD 18.2482
110 3W2E FAD 18.8192
111 3W2E NAD 18.8192
112 6EBQ FMN 23.125
113 3JQQ A2P 25
114 3JQQ FAD 25
115 2XNJ NAP 26.3158
116 2XNJ FAD 26.3158
117 2FCR FMN 27.1676
118 2WC1 FMN 29.6703
119 4BMO FMN 30.2521
120 2RC5 FAD 30.2548
121 5NUL FMN 30.4348
122 5K9B FMN 30.5556
123 5VEG FMN 31.4607
124 5VW2 NAP 31.962
125 5VW2 FDA 31.962
126 5H5J FAD 32.3625
127 1OBV FMN 34.9112
128 2BSA NAP 34.9835
129 2BSA FAD 34.9835
130 1EWY FAD 35.3135
131 1FND A2P 35.6688
132 1FND FAD 35.6688
133 1QFY FAD 35.7143
134 1QFY NAP 35.7143
135 1GAW FAD 36.3057
136 1AG9 FMN 36.5714
137 3VO1 FAD 36.9427
138 1SM4 FAD 37.5
139 3MHP FAD 37.5
140 1CZR FMN 37.8698
141 3KAP FMN 38.7755
142 2QTZ NAP 40.4453
143 2QTZ FAD 40.4453
144 6GAQ FMN 41.5584
145 6FSG FMN 42.1769
146 4HEQ FMN 43.1507
147 1BVY FMN 44.5026
148 5LJI FMN 44.5946
149 1AKV FMN 45.5782
150 4OXX FMN 45.679
151 3F6R FMN 45.9459
152 1F20 NAP 48.5057
153 1F20 FAD 48.5057
154 1TLL FAD 49.1909
155 1TLL FMN 49.1909
156 1TLL NAP 49.1909
Pocket No.: 3; Query (leader) PDB : 5FA6; Ligand: NAP; Similar sites found with APoc: 157
This union binding pocket(no: 3) in the query (biounit: 5fa6.bio1) has 71 residues
No: Leader PDB Ligand Sequence Similarity
1 1FUR MLT 1.07066
2 4KCT FDP 1.2024
3 1LJ8 NAD 1.21704
4 3HQP FDP 1.40281
5 3RC3 ANP 1.61812
6 2POC BG6 1.63488
7 1X9I G6Q 1.65563
8 3O03 GCO 1.71821
9 2OHH FMN 1.73267
10 1E5D FMN 1.99005
11 2RDE C2E 1.99203
12 3B5J 12D 2.05761
13 3VPD CIT 2.13523
14 4IP7 FBP 2.20994
15 4PPF FLC 2.28571
16 4AMV F6R 2.29885
17 1J78 OLA 2.40175
18 6FRN FMN 2.43902
19 5HV7 RBL 2.52294
20 4YHB FAD 2.5641
21 4GLW NMN 2.62295
22 4D86 ADP 2.75081
23 6BYF CIT 2.94118
24 4C0X FMN 2.95567
25 2BZZ AP5 2.96296
26 3S2Y FMN 3.01508
27 1G6H ADP 3.11284
28 2AWN ADP 3.14961
29 4YRY FAD 3.26087
30 4YRY NAD 3.26087
31 5JCA FAD 3.39806
32 1I36 NAP 3.40909
33 4G1V FAD 3.50877
34 1BO4 COA 3.57143
35 3LN9 FLC 3.59712
36 4B2D FBP 3.64964
37 1KZL CRM 3.84615
38 4LO6 SIA GAL 4.21053
39 1EP2 FAD 4.21456
40 3KL3 GCU 4.2394
41 5MJI 7O6 4.28016
42 5CEO 50D 4.33333
43 2Z9C FMN 4.5
44 2Z9C DTC 4.5
45 4R81 FMN 4.85437
46 2Y65 ADP 4.93151
47 2P3I MNA 4.96894
48 1USF NAP 5.05618
49 3CRZ FAD 5.05837
50 3CRZ NAP 5.05837
51 5YLY FAD 5.13699
52 5NM7 GLY 5.26316
53 3ITJ CIT 5.32544
54 4B4D FAD 5.34351
55 4DS0 A2G GAL NAG FUC 5.52147
56 5E5U MLI 5.68182
57 4G6I RS3 5.71429
58 3I7V B4P 5.97015
59 3IVV ASP GLU VAL THR SER THR THR SER SER SER 6.2069
60 6GEH FAD 6.25
61 4EOY ASN ASP TRP LEU LEU PRO SER TYR 6.25
62 3OZV FAD 6.45161
63 1KOJ PAN 6.4632
64 3KYF 5GP 5GP 6.49351
65 2FJK 13P 6.55738
66 2OYS FMN 6.61157
67 4WOH 4NP 6.62651
68 2BVE PH5 6.72269
69 2Q9U FMN 7.00483
70 2O2C G6Q 7.01468
71 1RJW ETF 7.07965
72 2CXS F6P 7.18133
73 1RLJ FMN 7.19424
74 1O5O U5P 7.23982
75 5WHT SIA GAL 7.24638
76 1JJ7 ADP 7.30769
77 1PVC ILE SER GLU VAL 7.35294
78 3A3B FMN 7.36842
79 5O0X FAD 7.90378
80 4UP4 GAL NAG 7.98005
81 3SVL FMN 8.29016
82 4U9U FAD 8.8968
83 1A8P FAD 8.91473
84 1T5B FMN 8.95522
85 5EOO CIT 9.0566
86 4ONT SIA GAL BGC 9.30233
87 2JBM SRT 9.699
88 2VNI A2P 9.92647
89 2VNI FAD 9.92647
90 4LTN FMN 10.1523
91 4LTN NAI 10.1523
92 2D2F ADP 10.8
93 3CQO FUC 10.9215
94 3N39 FMN 10.9718
95 4PTZ FMN 10.9948
96 2CHT TSA 11.0236
97 1T0I FMN 11.5183
98 2EIX FAD 11.9342
99 1N13 AG2 12.3894
100 2QQC AG2 12.5
101 3GFS FMN 12.6437
102 2PIA FMN 13.7072
103 1KRH FAD 14.497
104 4WQM FAD 15.6442
105 5LMC FMN 15.6576
106 2CND FAD 15.9259
107 5OGX FAD 16.0714
108 4N82 FMN 16.2921
109 4R2I ANP 17.1429
110 1QX4 FAD 18.2482
111 3W2E NAD 18.8192
112 3W2E FAD 18.8192
113 6EBQ FMN 23.125
114 3JQQ A2P 25
115 3JQQ FAD 25
116 2XNJ NAP 26.3158
117 2XNJ FAD 26.3158
118 2FCR FMN 27.1676
119 2WC1 FMN 29.6703
120 4BMO FMN 30.2521
121 2RC5 FAD 30.2548
122 5NUL FMN 30.4348
123 5K9B FMN 30.5556
124 5VEG FMN 31.4607
125 5VW2 FDA 31.962
126 5VW2 NAP 31.962
127 5H5J FAD 32.3625
128 1OBV FMN 34.9112
129 2BSA NAP 34.9835
130 2BSA FAD 34.9835
131 1EWY FAD 35.3135
132 1FND A2P 35.6688
133 1FND FAD 35.6688
134 1QFY FAD 35.7143
135 1QFY NAP 35.7143
136 1GAW FAD 36.3057
137 1AG9 FMN 36.5714
138 3VO1 FAD 36.9427
139 1SM4 FAD 37.5
140 3MHP FAD 37.5
141 1CZR FMN 37.8698
142 3KAP FMN 38.7755
143 2QTZ NAP 40.4453
144 2QTZ FAD 40.4453
145 6GAQ FMN 41.5584
146 6FSG FMN 42.1769
147 4HEQ FMN 43.1507
148 1BVY FMN 44.5026
149 5LJI FMN 44.5946
150 1AKV FMN 45.5782
151 4OXX FMN 45.679
152 3F6R FMN 45.9459
153 1F20 NAP 48.5057
154 1F20 FAD 48.5057
155 1TLL FAD 49.1909
156 1TLL FMN 49.1909
157 1TLL NAP 49.1909
Pocket No.: 4; Query (leader) PDB : 5FA6; Ligand: FAD; Similar sites found with APoc: 26
This union binding pocket(no: 4) in the query (biounit: 5fa6.bio2) has 71 residues
No: Leader PDB Ligand Sequence Similarity
1 2ZJ3 G6P 1.6
2 1MOQ GLP 1.90217
3 2RDE C2E 1.99203
4 5D63 FUC GAL GLA 2.04778
5 1NLU IVA PHI TYB 2.7027
6 1MZC SUC 2.91262
7 2FN1 SAL 3.43249
8 1G8S MET 3.47826
9 4AZW SAM 3.82166
10 1LYX PGA 4.03226
11 5A6M XYP XYP 4.15648
12 2WZF BGC 4.19048
13 1EWK GLU 4.28571
14 4B9E FAH 4.31894
15 5KZD RCJ 4.43686
16 1KQR MNA 4.46927
17 5EJL C2E 6.04839
18 4IF4 BEF 6.25
19 2ACV UDP 6.91145
20 2Z48 A2G 6.94444
21 3JU6 ARG 7.02703
22 5WHT SIA GAL GLC 7.24638
23 5WHT SIA 7.24638
24 3MAG 3MA 8.14332
25 3BMN AX3 15.625
26 4KFU ACP 19.3396
Pocket No.: 5; Query (leader) PDB : 5FA6; Ligand: NAP; Similar sites found with APoc: 24
This union binding pocket(no: 5) in the query (biounit: 5fa6.bio2) has 72 residues
No: Leader PDB Ligand Sequence Similarity
1 2ZJ3 G6P 1.6
2 1MOQ GLP 1.90217
3 5D63 FUC GAL GLA 2.04778
4 1MZC SUC 2.91262
5 2FN1 SAL 3.43249
6 1G8S MET 3.47826
7 1LYX PGA 4.03226
8 5A6M XYP XYP 4.15648
9 2WZF BGC 4.19048
10 1EWK GLU 4.28571
11 3S6X SIA GAL BGC 4.30769
12 4B9E FAH 4.31894
13 5KZD RCJ 4.43686
14 1KQR MNA 4.46927
15 5EJL C2E 6.04839
16 4IF4 BEF 6.25
17 2ACV UDP 6.91145
18 2Z48 A2G 6.94444
19 3JU6 ARG 7.02703
20 5WHT SIA GAL GLC 7.24638
21 5WHT SIA 7.24638
22 3MAG 3MA 8.14332
23 3BMN AX3 15.625
24 4KFU ACP 19.3396
Pocket No.: 6; Query (leader) PDB : 5FA6; Ligand: FMN; Similar sites found with APoc: 27
This union binding pocket(no: 6) in the query (biounit: 5fa6.bio2) has 70 residues
No: Leader PDB Ligand Sequence Similarity
1 2ZJ3 G6P 1.6
2 1MOQ GLP 1.90217
3 2RDE C2E 1.99203
4 5D63 FUC GAL GLA 2.04778
5 2F5X ASP 2.5641
6 1MZC SUC 2.91262
7 2FN1 SAL 3.43249
8 1G8S MET 3.47826
9 4AZW SAM 3.82166
10 1VMK GUN 3.97112
11 2Y9G LAT 4
12 2Y9G LBT 4
13 1LYX PGA 4.03226
14 5A6M XYP XYP 4.15648
15 2WZF BGC 4.19048
16 1EWK GLU 4.28571
17 4B9E FAH 4.31894
18 1KQR MNA 4.46927
19 5EJL C2E 6.04839
20 2Z48 A2G 6.94444
21 3JU6 ARG 7.02703
22 5WHT SIA GAL GLC 7.24638
23 5WHT SIA 7.24638
24 3MAG 3MA 8.14332
25 3UWV 2PG 8.81226
26 3BMN AX3 15.625
27 4KFU ACP 19.3396
APoc FAQ
Feedback