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Receptor
PDB id Resolution Class Description Source Keywords
4ZNO 1.86 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF DLN1 COMPLEXED WITH SUCROSE DANIO RERIO PORE-FORMING PROTEIN AEOLYSIN-LIKE PROTEIN VETEBRATE HIGHGLYCANS COMPLEX SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECEPTOR RECOGNITION AND PORE OF A ZEBRAFISH AEROLYSIN-LIKE PROTEIN. EMBO REP. V. 17 235 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL B:402;
A:402;
Invalid;
Invalid;
none;
none;
submit data
35.453 Cl [Cl-]
EPE B:403;
Invalid;
none;
submit data
238.305 C8 H18 N2 O4 S C1CN(...
SUC A:401;
B:401;
Valid;
Valid;
none;
none;
submit data
342.296 C12 H22 O11 C([C@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4ZNO 1.86 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF DLN1 COMPLEXED WITH SUCROSE DANIO RERIO PORE-FORMING PROTEIN AEOLYSIN-LIKE PROTEIN VETEBRATE HIGHGLYCANS COMPLEX SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECEPTOR RECOGNITION AND PORE OF A ZEBRAFISH AEROLYSIN-LIKE PROTEIN. EMBO REP. V. 17 235 2016
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 4ZNO - SUC C12 H22 O11 C([C@@H]1[....
2 4ZNR - MAN MAN n/a n/a
3 4ZNQ - MAN MAN n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 4ZNO - SUC C12 H22 O11 C([C@@H]1[....
2 4ZNR - MAN MAN n/a n/a
3 4ZNQ - MAN MAN n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 4ZNO - SUC C12 H22 O11 C([C@@H]1[....
2 4ZNR - MAN MAN n/a n/a
3 4ZNQ - MAN MAN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SUC; Similar ligands found: 16
No: Ligand ECFP6 Tc MDL keys Tc
1 SUC 1 1
2 SWE 1 1
3 RAF 0.736842 0.972973
4 STW 0.724138 0.972973
5 SUP 0.701754 0.8
6 DQR 0.666667 0.972973
7 NYT 0.612903 0.972973
8 FNY 0.612903 0.972973
9 20S 0.534247 0.8
10 SUC GLA 0.5 0.921053
11 AGR 0.467532 0.782609
12 TRE 0.42 0.864865
13 AMG 0.411765 0.789474
14 MMA 0.411765 0.789474
15 GYP 0.411765 0.789474
16 MBG 0.411765 0.789474
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4ZNO; Ligand: SUC; Similar sites found with APoc: 403
This union binding pocket(no: 1) in the query (biounit: 4zno.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 5B4T NAD 1.15385
2 5B4T 3HR 1.15385
3 5HXI 5HN 1.19403
4 5HXI FAD 1.19403
5 4D9C PMP 1.49254
6 1ZGA SAH 1.49254
7 4DSG UDP 1.49254
8 4DSG FAD 1.49254
9 5LD5 NAD 1.49254
10 1FL2 FAD 1.6129
11 3CH6 311 1.74825
12 3CH6 NAP 1.74825
13 6FHO FAD 1.75439
14 3NKS FAD 1.79104
15 4XQC 13D 1.79104
16 2Q4W FAD 1.79104
17 1RM4 NDP 1.79104
18 1J0D 5PA 1.79104
19 3A1I UNU 1.79104
20 1ZK7 FAD 1.79104
21 5YU3 PRO 1.79104
22 5YU3 NAD 1.79104
23 1U6R ADP 1.79104
24 1XG5 NAP 1.79211
25 3KRB NAP 1.79641
26 1E7S NAP 1.86916
27 2AE2 NAP 1.92308
28 2AE2 PTO 1.92308
29 3CQD ATP 1.94175
30 3NUG NAD 2.02429
31 3C8F MT2 2.04082
32 1JQD SAH 2.05479
33 1JQD HSM 2.05479
34 1ELI PYC 2.08955
35 1BW9 NAD 2.08955
36 2IVD FAD 2.08955
37 1BXG NAD 2.08955
38 1D4D FAD 2.08955
39 2C5A GDC 2.08955
40 2C5A NAD 2.08955
41 5GSN FAD 2.08955
42 5GSN MMZ 2.08955
43 2DKH FAD 2.08955
44 2XVF FAD 2.08955
45 5GSN NAP 2.08955
46 1OYB HBA 2.08955
47 1OYB FMN 2.08955
48 5BUK FAD 2.08955
49 3CMC NAD 2.09581
50 1CER NAD 2.1148
51 1XKQ NDP 2.14286
52 3CB2 GDP 2.31579
53 3KLJ FAD 2.38806
54 2CUN 3PG 2.38806
55 3T31 DCQ 2.38806
56 3T31 FAD 2.38806
57 1V59 FAD 2.38806
58 1QO8 FAD 2.38806
59 4MIG G3F 2.38806
60 5X68 FAD 2.38806
61 1Q9I FAD 2.38806
62 1Q9I TEO 2.38806
63 6ER9 FAD 2.38806
64 1YKJ PHB 2.38806
65 1YKJ FAD 2.38806
66 3TKY SAH 2.38806
67 3P9C SAH 2.38806
68 1V59 NAD 2.38806
69 4KQW NAP 2.38806
70 2DFV NAD 2.38806
71 5IVE 6E8 2.42424
72 4J7U YTZ 2.43056
73 4J7U NAP 2.43056
74 1NVM NAD 2.5641
75 2QV6 GTP 2.61194
76 4HA6 FAD 2.68657
77 4Z24 FAD 2.68657
78 5ZYN FAD 2.68657
79 3K7M FAD 2.68657
80 4XB2 NDP 2.68657
81 5TWB FAD 2.68657
82 5AE2 FAD 2.68657
83 4XB2 HSE 2.68657
84 1RQ5 CTT 2.68657
85 4OOE NDP 2.68657
86 2ZAT NAP 2.69231
87 4Z0H NAD 2.69461
88 1ZK4 AC0 2.78884
89 1DL5 SAH 2.83912
90 5Z2L NDP 2.85714
91 4RF2 NAP 2.94118
92 2X6T NAP 2.98507
93 2AQJ FAD 2.98507
94 3GD4 NAD 2.98507
95 3GD4 FAD 2.98507
96 4G2R H1L 2.98507
97 3AB1 FAD 2.98507
98 1FP2 SAH 2.98507
99 3HDY GDU 2.98507
100 3HDY FAD 2.98507
101 3UZO GLU 2.98507
102 1FP2 HMO 2.98507
103 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 2.98507
104 2JDR L20 2.98507
105 1RPN NDP 2.98507
106 2BQP GLC 2.99145
107 4MDH NAD 2.99401
108 2CUL FAD 3.01724
109 2IVN ANP 3.0303
110 5F52 ASP 3.04878
111 1EQ2 NAP 3.22581
112 1H82 GZZ 3.28358
113 1H82 FAD 3.28358
114 2B9W FAD 3.28358
115 3LST SAH 3.28358
116 5AB7 MLC 3.28358
117 16PK BIS 3.28358
118 2C31 TZD 3.28358
119 2C31 ADP 3.28358
120 4YKG FAD 3.28358
121 1KEV NDP 3.28358
122 3EYA TDP 3.28358
123 1SB8 UD2 3.28358
124 1SB8 NAD 3.28358
125 2B4R AES 3.28358
126 2B4R NAD 3.28358
127 5UR0 NAD 3.28358
128 5GM9 CBK 3.28639
129 3KB6 NAD 3.29341
130 5OVL NAP 3.33333
131 2JK0 ASP 3.38462
132 6F7L FAD 3.39367
133 3ZYR NAG NAG BMA MAN MAN NAG NAG 3.44828
134 3ZYR ASN NAG NAG BMA MAN MAN NAG NAG 3.44828
135 4RPL 3UC 3.58209
136 4RPL FAD 3.58209
137 3GDN HBX 3.58209
138 3GDN FAD 3.58209
139 4MOP 2H5 3.58209
140 2IID FAD 3.58209
141 2IID PHE 3.58209
142 3GMB FAD 3.58209
143 4O33 TZN 3.58209
144 4O33 3PG 3.58209
145 6F97 FAD 3.58209
146 1PN0 FAD 3.58209
147 1PN0 IPH 3.58209
148 1EKO I84 3.58209
149 2GJP MAL 3.58209
150 2ZC0 PMP 3.58209
151 4CQM NAP 3.68852
152 2GJ5 VD3 3.7037
153 1H74 ILE 3.71622
154 3STK PLM 3.78788
155 4KWI NAP 3.80228
156 4KWI 1TJ 3.80228
157 5ZZ6 NAD 3.84615
158 6GAS FAD 3.8806
159 4D04 FAD 3.8806
160 4D04 NAP 3.8806
161 4YRY FAD 3.8806
162 5MZI FAD 3.8806
163 5MZI FYK 3.8806
164 2VVM FAD 3.8806
165 2VVL FAD 3.8806
166 2J62 GSZ 3.8806
167 2F5Z FAD 3.8806
168 3X0V FAD 3.8806
169 3OZ2 FAD 3.8806
170 5MQ5 ASP 3.91566
171 5K4G ASP 3.93939
172 2RH4 EMO 3.97112
173 2RHO GSP 4
174 4J5R A1R 4.10959
175 1O8B ABF 4.10959
176 2BFR ADP 4.16667
177 2YG3 FAD 4.1791
178 1AE1 NAP 4.1791
179 4YNU LGC 4.1791
180 1W5F G2P 4.1791
181 6DAM PQQ 4.1791
182 1OFD AKG 4.1791
183 1OFD FMN 4.1791
184 4YNU FAD 4.1791
185 2YYY NAP 4.1791
186 4A6D SAM 4.1791
187 1E3W NAD 4.21456
188 5OJI NAP 4.23077
189 1SG4 CO8 4.23077
190 3OID NDP 4.26357
191 1LYX PGA 4.43548
192 4U8P FDA 4.47761
193 2ZPA ACO 4.47761
194 2I0K FAD 4.47761
195 4U8P UDP 4.47761
196 4J56 FAD 4.47761
197 3V1Y NAD 4.47761
198 5HSA FAS 4.47761
199 2D7I NGA 4.47761
200 4OM8 NAD 4.53074
201 1WMA NDP 4.71014
202 1WMA AB3 4.71014
203 3TO7 COA 4.71014
204 3GF4 UPG 4.77612
205 3GF4 FAD 4.77612
206 3A06 NDP 4.77612
207 3A06 FOM 4.77612
208 4XH4 PPI 4.77612
209 4XH4 ANP 4.77612
210 1RKX NAD 4.77612
211 2ZUX RAM 4.77612
212 5NII FAD 4.85437
213 5CFT 51G 4.86486
214 3AB4 THR 5.05618
215 3Q9T FAY 5.07463
216 4MO2 FAD 5.07463
217 4MO2 FDA 5.07463
218 5A1S FLC 5.07463
219 3O3R NAP 5.07463
220 5BRT FAD 5.07463
221 3AYI HCI 5.07463
222 3AYI FAD 5.07463
223 4CNK FAD 5.07463
224 2RGJ FAD 5.07463
225 3L4S NAD 5.07463
226 3L4S 3PG 5.07463
227 1QZZ SAM 5.08021
228 3WQQ IB3 5.12295
229 3WQQ NDP 5.12295
230 5WQP NAP 5.12821
231 1NPD NAD 5.20833
232 5GT9 NAP 5.32319
233 1ZEM NAD 5.34351
234 1FP1 SAH 5.37313
235 2JE7 XMM 5.43933
236 1WPY BTN 5.53191
237 5L4S NAP 5.66038
238 5L4S 6KX 5.66038
239 4EUE NAI 5.67164
240 4LY9 1YY 5.67164
241 4LY9 S6P 5.67164
242 5Z21 NAI 5.67164
243 1X1T NAD 5.76923
244 2Q7V FAD 5.84615
245 4KP7 NAP 5.8548
246 4KP7 1UQ 5.8548
247 3B20 NAD 5.8997
248 3B1J NAD 5.8997
249 2YVJ FAD 5.97015
250 1TUF AZ1 5.97015
251 6A0S HSE 5.97015
252 6A0S NDP 5.97015
253 4D7E FAD 5.97015
254 5KOX RFP 5.97015
255 5KOX FAD 5.97015
256 2A2C ADP 5.97015
257 2A2C NG1 5.97015
258 1JOT GAL A2G 6.01504
259 5J60 FAD 6.25
260 4K5S FAD 6.26866
261 4K5S PM0 6.26866
262 3ITJ FAD 6.26866
263 2HIM ASN 6.26866
264 2HIM ASP 6.26866
265 5YB7 FAD 6.26866
266 5YB7 ORN 6.26866
267 4ZAH T5K 6.26866
268 4LZJ 22H 6.27063
269 4I2D APC 6.56716
270 3CIF NAD 6.56716
271 3CIF G3H 6.56716
272 1LTH NAD 6.58307
273 6HKE LMR 6.60377
274 6HKE MLT 6.60377
275 1SAY PYR 6.6482
276 3QPB R1P 6.73759
277 3O26 NDP 6.75241
278 3EWP APR 6.77966
279 1Q0H NDP 6.86567
280 1Q0H FOM 6.86567
281 4AT0 FAD 6.86567
282 5EVY FAD 6.86567
283 3LU1 NAD 6.86567
284 3RNM FAD 6.89655
285 2BD0 NAP 6.96721
286 3EWR APR 7.14286
287 3ICS ADP 7.16418
288 3ICR FAD 7.16418
289 2NP9 YE1 7.16418
290 1MO9 FAD 7.26577
291 1MO9 KPC 7.26577
292 4O0L NDP 7.27273
293 1DUB CAA 7.27969
294 2CVQ NDP 7.33945
295 4M00 SUC 7.46269
296 2ABJ CBC 7.46269
297 1GAD NAD 7.46269
298 2DTX BMA 7.57576
299 2JAH NDP 7.69231
300 2JAP NDP 7.69231
301 1UOU CMU 8.0597
302 1HKU NAD 8.0597
303 2ZXI FAD 8.0597
304 5THQ NDP 8.08823
305 4UP3 FAD 8.28025
306 4MSG 2C6 8.35821
307 1IYE PGU 8.35821
308 2QWO ADP 8.35821
309 4I42 1HA 8.42105
310 5UAO FAD 8.65672
311 1XSE NDP 8.81356
312 1MVQ MMA 8.8983
313 4J36 FAD 8.95522
314 5JY6 NAD 8.95522
315 4J36 1HR 8.95522
316 1GUA GNP 8.98204
317 1UGX GAL MGC 9.02256
318 1WS5 MMA 9.02256
319 1WS4 AMG 9.02256
320 1WS4 GYP 9.02256
321 1UGY GLA BGC 9.02256
322 1UGY GLA GLC 9.02256
323 1UGW GAL 9.02256
324 1KUJ MMA 9.02256
325 1M26 GAL A2G 9.02256
326 1JAC AMG 9.02256
327 5NMX FAD 9.25373
328 5NMX NAP 9.25373
329 5V6F MAN BMA MAN 9.42029
330 4I4Z 2NE 9.45455
331 1XHL NDP 9.76431
332 3H7U NAP 9.85075
333 1XXR MAN 9.93789
334 4XYM COA 10
335 5DNC ASN 10.1493
336 4IV9 FAD 10.1493
337 4R8L ASP 10.1493
338 6CI9 NAP 10.4247
339 1O5I NAD 10.4418
340 4REP FAD 10.4478
341 4QIJ 1HA 10.479
342 4B5P ACO 10.5
343 3AXK NDP 10.8527
344 1C3M MAN MAN 10.8844
345 2FLI DX5 10.9091
346 4GUT FAD 11.2903
347 1UWK URO 11.6418
348 1UWK NAD 11.6418
349 3CTL S6P 11.6883
350 1VL8 NAP 11.985
351 1LES GLC FRU 13.4615
352 1LOB MMA 13.4615
353 1LOF MAN BMA NAG NAG MAN NAG GAL GAL 13.4615
354 4YSX FAD 13.4615
355 5EPO NAP 14.5038
356 1RM6 FAD 14.9068
357 4C3Y FAD 14.9254
358 4C3Y ANB 14.9254
359 1TOQ AMG 15
360 3ENG CBI 15.493
361 1VBO MAN MAN MAN 17.4497
362 1VBO MAN 17.4497
363 3QV1 NAD 18.2927
364 1ZGS XMM 19.1045
365 1O94 ADP 20.3125
366 1OFS SUC 20.8333
367 2FMD MAN MAN 20.8333
368 2GMM MAN MAN 21.0317
369 2GMP NAG MAN 21.0317
370 2GN3 MAN 21.0317
371 2PHU MAN MAN 21.0317
372 1Q8V MAN MAN MAN 21.0317
373 2GND MAN 21.0317
374 2GN3 MMA 21.0317
375 2GNM MAN 21.0317
376 2PHF MAN MAN BMA MAN 21.0317
377 2PHU MAN MAN MAN BMA MAN 21.0317
378 2PHT MAN MAN MAN BMA MAN 21.0317
379 1Q8O MAN MMA 21.0317
380 2PHR MAN MAN BMA MAN 21.0317
381 1Q8V MAN MAN 21.0317
382 2GND MAN MMA 21.0317
383 2PHF MAN MAN 21.0317
384 2PHR MAN MAN 21.0317
385 2PHW MAN MAN 21.0317
386 2PHW MAN MAN MAN BMA MAN MAN MAN 21.0317
387 2PHT MAN MAN MAN 21.0317
388 1Q8P MAN MMA 21.0317
389 2GNB MAN 21.0317
390 2AUY NAG MAN MMA 21.0317
391 2AR6 NAG MAN MAN MAN NAG 21.0317
392 2AR6 NAG MAN 21.0317
393 1UKG MMA 21.0317
394 1Q8Q MAN MMA 21.0317
395 1Q8S MAN MMA 21.0317
396 2PHX MAN MAN MAN MAN 21.0317
397 2PHX MAN MAN 21.0317
398 5XFI NAG NAG BMA MAN MAN NAG GAL NAG 22.2222
399 2GAG NAD 22.2222
400 2GAG FAD 22.2222
401 5EYY MDM 25.3061
402 6FLZ MMA 30.5556
403 2BMZ XLM 39.0071
Pocket No.: 2; Query (leader) PDB : 4ZNO; Ligand: SUC; Similar sites found with APoc: 65
This union binding pocket(no: 2) in the query (biounit: 4zno.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 1N5D NDP 1.73611
2 1LVL FAD 1.79104
3 1XDS SAM 1.87166
4 3RFV NAI 1.87266
5 1K2V DEF 1.8797
6 1ZUA NAP 1.89274
7 1ZUA TOL 1.89274
8 5X8G S0N 2.08955
9 1C1X NAD 2.08955
10 4USR FAD 2.38806
11 5TTJ FAD 2.38806
12 4HA9 NDP 2.38806
13 1KYZ SAH 2.38806
14 2VAP GDP 2.38806
15 2AOT SAH 2.38806
16 1GPE FAD 2.38806
17 3B1Q NOS 2.45399
18 3TTC ADP 2.68657
19 5BV3 M7G 2.68657
20 3HDY FDA 2.98507
21 5NUE NAD 3.01205
22 3E1T FAD 3.28358
23 1GAR U89 3.30189
24 1X7D ORN 3.58209
25 1X7D NAD 3.58209
26 1R37 NAD 3.7464
27 1U7T TDT 3.83142
28 2PT9 2MH 3.8806
29 2PT9 S4M 3.8806
30 2XA2 UPG 3.8806
31 2WSB NAD 3.93701
32 1L3I SAH 4.16667
33 4M52 FAD 4.1791
34 1YQZ FAD 4.1791
35 3PC3 P1T 4.1791
36 5I60 67W 4.77612
37 1PS9 FAD 4.77612
38 5E5U MLI 4.92424
39 1LSS NAD 5
40 5MBX FAD 5.07463
41 5MBX SP5 5.07463
42 1GS5 ANP 5.81395
43 1GS5 NLG 5.81395
44 1PFK ADP 5.9375
45 5J7X FAD 5.97015
46 5JWC FAD 6.26866
47 1XPK HMG 6.4433
48 1HYH NAD 6.47249
49 4X6I 3Y1 6.51163
50 5EEH SAH 6.56716
51 5EEH P9P 6.56716
52 2RAB FAD 6.86567
53 1GET FAD 7.16418
54 3ICS FAD 7.16418
55 1PR9 NAP 7.37705
56 4DV8 0LX 8.0597
57 5ZI9 FLC 8.07692
58 2Y6Q FAD 8.35821
59 2Y6Q I7T 8.35821
60 1QX4 FAD 9.48905
61 1I8T FAD 9.55224
62 3C6K SPD 12.5373
63 3C6K MTA 12.5373
64 5JIC ADP 15.3846
65 1IG3 VIB 16.73
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