Receptor
PDB id Resolution Class Description Source Keywords
4ZNO 1.86 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF DLN1 COMPLEXED WITH SUCROSE DANIO RERIO PORE-FORMING PROTEIN AEOLYSIN-LIKE PROTEIN VETEBRATE HIGHGLYCANS COMPLEX SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECEPTOR RECOGNITION AND PORE OF A ZEBRAFISH AEROLYSIN-LIKE PROTEIN. EMBO REP. V. 17 235 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL B:402;
A:402;
Invalid;
Invalid;
none;
none;
submit data
35.453 Cl [Cl-]
EPE B:403;
Invalid;
none;
submit data
238.305 C8 H18 N2 O4 S C1CN(...
SUC A:401;
B:401;
Valid;
Valid;
none;
none;
submit data
342.296 C12 H22 O11 C([C@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4ZNO 1.86 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF DLN1 COMPLEXED WITH SUCROSE DANIO RERIO PORE-FORMING PROTEIN AEOLYSIN-LIKE PROTEIN VETEBRATE HIGHGLYCANS COMPLEX SUGAR BINDING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECEPTOR RECOGNITION AND PORE OF A ZEBRAFISH AEROLYSIN-LIKE PROTEIN. EMBO REP. V. 17 235 2016
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 4ZNO - SUC C12 H22 O11 C([C@@H]1[....
2 4ZNR - MAN MAN n/a n/a
3 4ZNQ - MAN MAN n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 4ZNO - SUC C12 H22 O11 C([C@@H]1[....
2 4ZNR - MAN MAN n/a n/a
3 4ZNQ - MAN MAN n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 4ZNO - SUC C12 H22 O11 C([C@@H]1[....
2 4ZNR - MAN MAN n/a n/a
3 4ZNQ - MAN MAN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SUC; Similar ligands found: 19
No: Ligand ECFP6 Tc MDL keys Tc
1 GLC FRU 1 1
2 SWE 1 1
3 SUC 1 1
4 FRU GLC GLA 0.736842 0.972973
5 RAF 0.736842 0.972973
6 SUP 0.701754 0.8
7 GLC FRU FRU 0.684211 0.972973
8 DQR 0.666667 0.972973
9 FNY 0.612903 0.972973
10 NYT 0.612903 0.972973
11 20S 0.534247 0.8
12 SUC GLA 0.5 0.921053
13 AGR 0.467532 0.782609
14 TRE 0.42 0.864865
15 MMA 0.411765 0.789474
16 MBG 0.411765 0.789474
17 AMG 0.411765 0.789474
18 GYP 0.411765 0.789474
19 GLC GLC FRU 0.4 0.947368
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4ZNO; Ligand: SUC; Similar sites found: 184
This union binding pocket(no: 1) in the query (biounit: 4zno.bio1) has 9 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4D9C PMP 0.005432 0.43209 1.49254
2 3CH6 311 0.01832 0.4479 1.74825
3 3CH6 NAP 0.01832 0.4479 1.74825
4 3NKS FAD 0.009567 0.45249 1.79104
5 1U6R ADP 0.02939 0.40135 1.79104
6 2AE2 PTO 0.00166 0.5073 1.92308
7 2AE2 NAP 0.00166 0.5073 1.92308
8 3C8F MT2 0.01053 0.41121 2.04082
9 1JQD HSM 0.0319 0.40052 2.05479
10 1JQD SAH 0.03498 0.40052 2.05479
11 1ELI PYC 0.0016 0.48651 2.08955
12 1BW9 NAD 0.003702 0.44989 2.08955
13 1BXG NAD 0.00625 0.43473 2.08955
14 1D4D FAD 0.008048 0.43409 2.08955
15 5BUK FAD 0.04954 0.40036 2.08955
16 3CMC NAD 0.04293 0.40743 2.09581
17 3CB2 GDP 0.006449 0.42537 2.31579
18 3KLJ FAD 0.004835 0.47808 2.38806
19 2CUN 3PG 0.0002018 0.45673 2.38806
20 1Q9I FAD 0.02924 0.42581 2.38806
21 1Q9I TEO 0.02924 0.42581 2.38806
22 3TKY SAH 0.01528 0.42245 2.38806
23 1YKJ PHB 0.03297 0.41983 2.38806
24 1YKJ FAD 0.03297 0.41983 2.38806
25 4LCQ URQ 0.04349 0.40515 2.38806
26 4KQW NAP 0.01897 0.40381 2.38806
27 2DFV NAD 0.02754 0.40165 2.38806
28 5IVE 6E8 0.029 0.40736 2.42424
29 4J7U YTZ 0.01427 0.43142 2.43056
30 4J7U NAP 0.01427 0.43142 2.43056
31 1NVM NAD 0.01341 0.41106 2.5641
32 2QV6 GTP 0.02359 0.41413 2.61194
33 4XB2 NDP 0.009404 0.42597 2.68657
34 4XB2 HSE 0.02343 0.41004 2.68657
35 4HA6 FAD 0.02189 0.40656 2.68657
36 1DL5 SAH 0.02329 0.42911 2.83912
37 2X6T NAP 0.003357 0.45847 2.98507
38 3AB1 FAD 0.03428 0.42457 2.98507
39 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.03386 0.40533 2.98507
40 2JDR L20 0.03386 0.40533 2.98507
41 2BQP GLC 0.000004169 0.56118 2.99145
42 4MDH NAD 0.02395 0.40899 2.99401
43 2CUL FAD 0.04452 0.40614 3.01724
44 2B9W FAD 0.008418 0.44419 3.28358
45 2B4R NAD 0.01715 0.41565 3.28358
46 3LST SAH 0.03464 0.41329 3.28358
47 3EYA TDP 0.01682 0.4108 3.28358
48 2B4R AES 0.02525 0.40571 3.28358
49 5GM9 CBK 0.0009837 0.47199 3.28639
50 2JK0 ASP 0.004499 0.42154 3.38462
51 3ZYR NAG NAG BMA MAN MAN NAG NAG 0.00004571 0.53283 3.44828
52 3ZYR ASN NAG NAG BMA MAN MAN NAG NAG 0.00005539 0.52618 3.44828
53 4RPL 3UC 0.000456 0.55761 3.58209
54 4RPL FAD 0.0009182 0.52773 3.58209
55 3GDN FAD 0.008247 0.46626 3.58209
56 3GDN HBX 0.01044 0.46626 3.58209
57 2IID FAD 0.02644 0.42345 3.58209
58 2IID PHE 0.02644 0.42345 3.58209
59 4O33 3PG 0.03088 0.41449 3.58209
60 4O33 TZN 0.03088 0.41449 3.58209
61 2GJP MAL 0.002677 0.4063 3.58209
62 2GJ5 VD3 0.01037 0.45134 3.7037
63 4YRY FAD 0.01618 0.43374 3.8806
64 1ZMD FAD 0.02113 0.42974 3.8806
65 2VVM FAD 0.01492 0.42445 3.8806
66 2J62 GSZ 0.01337 0.42176 3.8806
67 2RHO GSP 0.01779 0.42934 4
68 4J5R A1R 0.02246 0.41528 4.10959
69 1AE1 NAP 0.00125 0.50504 4.1791
70 4YNU LGC 0.006924 0.47001 4.1791
71 4YNU FAD 0.02025 0.42781 4.1791
72 3OID NDP 0.01935 0.41807 4.26357
73 1LYX PGA 0.008985 0.43223 4.43548
74 2ZPA ACO 0.01734 0.42714 4.47761
75 2I0K FAD 0.01872 0.42695 4.47761
76 4J56 FAD 0.02321 0.42139 4.47761
77 2D7I NGA 0.01948 0.40166 4.47761
78 3TO7 COA 0.03244 0.40676 4.71014
79 3A06 NDP 0.01423 0.43074 4.77612
80 3A06 FOM 0.01538 0.43074 4.77612
81 2ZUX RAM 0.008104 0.41163 4.77612
82 5CFT 51G 0.003951 0.431 4.86486
83 4MO2 FAD 0.003029 0.46164 5.07463
84 4MO2 FDA 0.0033 0.45921 5.07463
85 3Q9T FAY 0.02371 0.43861 5.07463
86 5A1S FLC 0.001165 0.4333 5.07463
87 3AYI HCI 0.02828 0.41778 5.07463
88 3AYI FAD 0.02759 0.41778 5.07463
89 4CNK FAD 0.02563 0.41742 5.07463
90 3WQQ NDP 0.01065 0.43798 5.12295
91 3WQQ IB3 0.01065 0.43798 5.12295
92 5L4S 6KX 0.01361 0.43993 5.66038
93 5L4S NAP 0.01361 0.43993 5.66038
94 4LY9 S6P 0.04456 0.41542 5.67164
95 4LY9 1YY 0.0458 0.41542 5.67164
96 4KP7 NAP 0.009975 0.45093 5.8548
97 4KP7 1UQ 0.01461 0.42904 5.8548
98 2YVJ FAD 0.004996 0.4756 5.97015
99 1TUF AZ1 0.01161 0.42717 5.97015
100 2HIM ASN 0.007143 0.40971 6.26866
101 2HIM ASP 0.008829 0.40291 6.26866
102 4I2D APC 0.003864 0.4219 6.56716
103 3CIF NAD 0.02228 0.40158 6.56716
104 3CIF G3H 0.03315 0.40045 6.56716
105 3O26 NDP 0.004746 0.45717 6.75241
106 2BD0 NAP 0.02969 0.40195 6.96721
107 3EWR APR 0.03269 0.41397 7.14286
108 3ICS ADP 0.009748 0.42753 7.16418
109 1MO9 FAD 0.0211 0.43597 7.26577
110 1MO9 KPC 0.02491 0.43594 7.26577
111 4M00 SUC 0.0003709 0.45052 7.46269
112 2ABJ CBC 0.02044 0.4045 7.46269
113 5THQ NDP 0.001955 0.48066 8.08823
114 4MSG 2C6 0.01654 0.43791 8.35821
115 2QWO ADP 0.04595 0.4001 8.35821
116 4I42 1HA 0.01779 0.44309 8.42105
117 5UAO FAD 0.02763 0.40737 8.65672
118 1XSE NDP 0.01164 0.44483 8.81356
119 4J36 1HR 0.02638 0.41434 8.95522
120 4J36 FAD 0.02418 0.40439 8.95522
121 1WS5 MMA 0.000385 0.4786 9.02256
122 1WS4 AMG 0.0003433 0.45533 9.02256
123 1WS4 GYP 0.0003511 0.45504 9.02256
124 1UGY GLA BGC 0.0003703 0.45385 9.02256
125 1UGY GLA GLC 0.0004699 0.44798 9.02256
126 1UGW GAL 0.000515 0.44578 9.02256
127 1KUJ MMA 0.0007398 0.44476 9.02256
128 1M26 GAL A2G 0.002088 0.43933 9.02256
129 1JAC AMG 0.001252 0.42524 9.02256
130 1XXR MAN 0.00000009917 0.61926 9.93789
131 4REP FAD 0.04036 0.42067 10.4478
132 4B5P ACO 0.03209 0.40985 10.5
133 1C3M MAN MAN 0.01457 0.45461 10.8844
134 4GUT FAD 0.009785 0.42361 11.2903
135 1UWK NAD 0.02306 0.41126 11.6418
136 1UWK URO 0.02306 0.41126 11.6418
137 1LES GLC FRU 0.000008332 0.51536 13.4615
138 1LOB MMA 0.00003576 0.43238 13.4615
139 4YSX FAD 0.02728 0.41997 13.4615
140 1LOF MAN BMA NAG NAG MAN NAG GAL GAL 0.00009334 0.40137 13.4615
141 1RM6 FAD 0.0287 0.4059 14.9068
142 4C3Y FAD 0.001212 0.48971 14.9254
143 4C3Y ANB 0.001661 0.48718 14.9254
144 1TOQ AMG 0.0005244 0.44484 15
145 3ENG CBI 0.002277 0.44077 15.493
146 1VBO MAN MAN MAN 0.000001278 0.60566 17.4497
147 1VBO MAN 0.000001723 0.58748 17.4497
148 3QV1 NAD 0.01355 0.40887 18.2927
149 3PNL ADP 0.02869 0.41316 18.4834
150 1ZGS XMM 0.000000118 0.59802 19.1045
151 1O94 ADP 0.00638 0.43627 20.3125
152 1OFS SUC 0.000007977 0.49015 20.8333
153 2GN3 MAN 0.000001955 0.57426 21.0317
154 1Q8V MAN MAN MAN 0.000005963 0.56604 21.0317
155 2GN3 MMA 0.000002893 0.56428 21.0317
156 2PHF MAN MAN BMA MAN 0.000008108 0.56246 21.0317
157 1Q8O MAN MMA 0.000006373 0.56159 21.0317
158 2PHR MAN MAN BMA MAN 0.000008029 0.56144 21.0317
159 1Q8V MAN MAN 0.000006043 0.55823 21.0317
160 2PHF MAN MAN 0.000009386 0.55429 21.0317
161 2PHR MAN MAN 0.000009484 0.55422 21.0317
162 2PHW MAN MAN 0.000009438 0.55409 21.0317
163 2PHW MAN MAN MAN BMA MAN MAN MAN 0.00001207 0.55387 21.0317
164 2PHX MAN MAN MAN MAN 0.000009103 0.55333 21.0317
165 1Q8P MAN MMA 0.00001034 0.55149 21.0317
166 2AR6 NAG MAN MAN MAN NAG 0.00002744 0.54533 21.0317
167 2AR6 NAG MAN 0.00002726 0.53916 21.0317
168 2GMM MAN MAN 0.000002384 0.53055 21.0317
169 2GNB MAN 0.000005502 0.52727 21.0317
170 2GNM MAN 0.000003965 0.51895 21.0317
171 2GMP NAG MAN 0.00004432 0.51683 21.0317
172 2PHX MAN MAN 0.0000595 0.50903 21.0317
173 2PHU MAN MAN 0.000003592 0.50473 21.0317
174 2GND MAN 0.000004679 0.50003 21.0317
175 2PHT MAN MAN MAN 0.000008131 0.47636 21.0317
176 1UKG MMA 0.000043 0.47503 21.0317
177 2GND MAN MMA 0.000008338 0.46316 21.0317
178 1Q8Q MAN MMA 0.00005744 0.45787 21.0317
179 1Q8S MAN MMA 0.00006521 0.45549 21.0317
180 2PHT MAN MAN MAN BMA MAN 0.000009234 0.43917 21.0317
181 2PHU MAN MAN MAN BMA MAN 0.000009307 0.43902 21.0317
182 2AUY NAG MAN MMA 0.00001872 0.42092 21.0317
183 5AV7 MMA MAN NAG MAN NAG NAG 0.0000008308 0.68645 22.5166
184 2BMZ XLM 0.00000008693 0.41816 39.0071
Pocket No.: 2; Query (leader) PDB : 4ZNO; Ligand: SUC; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4zno.bio1) has 9 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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