Receptor
PDB id Resolution Class Description Source Keywords
4a4l 2.35 Å EC: 2.7.11.21 CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 5-(2-AMINO-PYRIMIDIN-4-YL)-1H-PYRROLE INHIBITOR HOMO SAPIENS TRANSFERASE
Ref.: 5-(2-AMINO-PYRIMIDIN-4-YL)-1H-PYRROLE AND 2-(2-AMIN PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLO[3,2-C]PY ONE DERIVATIVES AS NEW CLASSES OF SELECTIVE AND ORA AVAILABLE POLO-LIKE KINASE 1 INHIBITORS. BIOORG.MED.CHEM.LETT. V. 22 96 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
939 A:1331;
Valid;
none;
ic50 = 0.015 uM
475.467 C22 H24 F3 N7 O2 Cn1cc...
TLA A:1330;
Invalid;
none;
submit data
150.087 C4 H6 O6 [C@@H...
ZN A:1329;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3FC2 2.45 Å EC: 2.7.11.21 PLK1 IN COMPLEX WITH BI6727 HOMO SAPIENS PROTEIN KINASE ATP-BINDING CELL CYCLE CELL DIVISION KINAMITOSIS NUCLEOTIDE-BINDING NUCLEUS PHOSPHOPROTEIN SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: BI 6727, A POLO-LIKE KINASE INHIBITOR WITH IMPROVED PHARMACOKINETIC PROFILE AND BROAD ANTITUMOR ACTIVIT CLIN.CANCER RES. V. 15 3094 2009
Members (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2RKU ic50 = 8 nM R78 C28 H39 N7 O3 CC[C@@H]1C....
2 4J53 ic50 = 2 nM 1J4 C27 H34 F3 N7 O3 CN1CCC(CC1....
3 2YAC ic50 = 0.003 uM 937 C24 H27 F3 N8 O3 CN1CCN(CC1....
4 4J52 ic50 = 3 nM 1J3 C28 H37 F N8 O3 CN1CCN(CC1....
5 3FC2 ic50 = 0.87 nM IBI C34 H50 N8 O3 CC[C@@H]1C....
6 4A4L ic50 = 0.015 uM 939 C22 H24 F3 N7 O2 Cn1cc(cc1c....
7 2OU7 ic50 = 140 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
8 3KB7 ic50 = 0.007 uM 071 C23 H28 N8 O2 Cn1c-2c(c(....
70% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2RKU ic50 = 8 nM R78 C28 H39 N7 O3 CC[C@@H]1C....
2 4J53 ic50 = 2 nM 1J4 C27 H34 F3 N7 O3 CN1CCC(CC1....
3 2YAC ic50 = 0.003 uM 937 C24 H27 F3 N8 O3 CN1CCN(CC1....
4 4J52 ic50 = 3 nM 1J3 C28 H37 F N8 O3 CN1CCN(CC1....
5 3FC2 ic50 = 0.87 nM IBI C34 H50 N8 O3 CC[C@@H]1C....
6 4A4L ic50 = 0.015 uM 939 C22 H24 F3 N7 O2 Cn1cc(cc1c....
7 2OU7 ic50 = 140 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
8 3KB7 ic50 = 0.007 uM 071 C23 H28 N8 O2 Cn1c-2c(c(....
9 3THB ic50 = 2 nM 3TA C23 H25 Cl N6 S Cc1c(cc(cn....
10 2OWB ic50 = 0.34 uM 626 C23 H24 N6 O2 S CN1CCN(CC1....
11 5TA6 ic50 = 1.5 nM 79D C30 H37 N9 O2 CC[C@@H]1c....
50% Homology Family (15)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 4I5M ic50 = 0.0088 uM R78 C28 H39 N7 O3 CC[C@@H]1C....
2 4I6H ic50 = 0.005 uM 1C8 C20 H23 N7 O S CC[C@@H]1C....
3 4I5P ic50 = 0.377 uM 1D1 C18 H23 N5 O CC[C@@H]1C....
4 4I6B ic50 = 1.45 uM 11G C14 H20 N4 O CC[C@@H]1C....
5 2RKU ic50 = 8 nM R78 C28 H39 N7 O3 CC[C@@H]1C....
6 4J53 ic50 = 2 nM 1J4 C27 H34 F3 N7 O3 CN1CCC(CC1....
7 2YAC ic50 = 0.003 uM 937 C24 H27 F3 N8 O3 CN1CCN(CC1....
8 4J52 ic50 = 3 nM 1J3 C28 H37 F N8 O3 CN1CCN(CC1....
9 3FC2 ic50 = 0.87 nM IBI C34 H50 N8 O3 CC[C@@H]1C....
10 4A4L ic50 = 0.015 uM 939 C22 H24 F3 N7 O2 Cn1cc(cc1c....
11 2OU7 ic50 = 140 uM ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
12 3KB7 ic50 = 0.007 uM 071 C23 H28 N8 O2 Cn1c-2c(c(....
13 3THB ic50 = 2 nM 3TA C23 H25 Cl N6 S Cc1c(cc(cn....
14 2OWB ic50 = 0.34 uM 626 C23 H24 N6 O2 S CN1CCN(CC1....
15 5TA6 ic50 = 1.5 nM 79D C30 H37 N9 O2 CC[C@@H]1c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 939; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 939 1 1
2 937 0.479675 0.82716
3 071 0.413223 0.853333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3FC2; Ligand: IBI; Similar sites found: 506
This union binding pocket(no: 1) in the query (biounit: 3fc2.bio1) has 31 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1UO5 PIH 0.001306 0.51384 None
2 1UO4 PIH 0.003973 0.47619 None
3 2O66 FLC 0.002262 0.45061 None
4 3PMD 11A 0.003184 0.42786 None
5 1LNX URI 0.01123 0.41424 None
6 3QP4 HL0 0.0007428 0.43842 1.0989
7 4N7C AEF 0.01335 0.42668 1.49254
8 1WVC CTP 0.003054 0.41617 1.5444
9 3JQ3 ADP 0.0001442 0.48299 1.79104
10 4L1F COS 0.00005916 0.44942 1.79104
11 1BUC CAA 0.0001171 0.4357 1.79104
12 2IZ1 ATR 0.006652 0.43516 1.79104
13 3I8P 840 0.001314 0.42908 1.79104
14 1TV5 ORO 0.001427 0.42555 1.79104
15 1Z44 FMN 0.002148 0.42539 1.79104
16 2BLE 5GP 0.0016 0.41262 1.79104
17 1Z41 FMN 0.004178 0.41013 1.79104
18 1Z48 FMN 0.004475 0.409 1.79104
19 4MOB ADP 0.00338 0.41161 1.80723
20 1WNG SAH 0.001293 0.4169 1.88679
21 1LYX PGA 0.004292 0.41373 2.01613
22 3V91 UPG 0.0006841 0.41869 2.06186
23 2W3L DRO 0.04766 0.41055 2.08333
24 3H86 AP5 0.002191 0.40399 2.08333
25 1RZM E4P 0.0003586 0.5026 2.08955
26 4LIT AKG 0.00056 0.47791 2.08955
27 3TKA CTN 0.0103 0.46365 2.08955
28 1RZM PEP 0.001693 0.45015 2.08955
29 2Z9V PXM 0.002707 0.44126 2.08955
30 1YHM AHD 0.004426 0.43746 2.08955
31 1Q11 TYE 0.01067 0.41522 2.08955
32 1T26 GBD 0.004854 0.41342 2.08955
33 1T26 NAI 0.004854 0.41342 2.08955
34 1DLJ UGA 0.001064 0.41161 2.08955
35 3TKA SAM 0.001614 0.40986 2.08955
36 1YBH FAD 0.0006544 0.40788 2.08955
37 1Q3Q ANP 0.002147 0.40704 2.08955
38 1Q0H NDP 0.001992 0.4014 2.08955
39 1TQP ATP 0.003919 0.44281 2.12766
40 2Y6P CTP 0.002096 0.43532 2.13675
41 2ORV 4TA 0.0001997 0.42837 2.13675
42 3NFZ 3NF 0.001704 0.434 2.14067
43 1NNS ASP 0.004463 0.42184 2.14724
44 3ZUY TCH 0.004612 0.42125 2.16718
45 1U7Z PMT 0.0001976 0.41534 2.21239
46 3EW2 BTN 0.007026 0.41829 2.22222
47 1HYE NAP 0.0003693 0.42367 2.23642
48 1AUX AGS 0.000001317 0.43104 2.2508
49 1M5B BN1 0.0002742 0.43531 2.28137
50 1OGD RIP 0.00558 0.42754 2.29008
51 3OCZ SRA 0.003529 0.40898 2.29008
52 3CEV ARG 0.008127 0.41561 2.34114
53 1QD0 RR6 0.00193 0.43185 2.34375
54 2BO4 FLC 0.001112 0.47889 2.38806
55 3ZPG 5GP 0.002786 0.47535 2.38806
56 3P7I P7I 0.006079 0.42591 2.38806
57 1SG4 CO8 0.0004347 0.41073 2.38806
58 2PTR 2SA 0.0005305 0.40812 2.38806
59 3B96 MYA 0.002878 0.40479 2.38806
60 1L8N GCW 0.001453 0.40441 2.38806
61 3PC3 P1T 0.002473 0.40355 2.38806
62 1JQ5 NAD 0.02088 0.40157 2.38806
63 1Z4V DAN 0.01176 0.4005 2.38806
64 2Q8M AMP 0.00188 0.4323 2.40964
65 2OWZ CIT 0.01741 0.41559 2.40964
66 1V35 NAI 0.001252 0.40168 2.43161
67 2PT9 2MH 0.000691 0.40105 2.49221
68 4K30 NLG 0.00425 0.43271 2.5
69 1NHZ 486 0.001181 0.41082 2.5
70 2B7N NTM 0.0101 0.42127 2.5641
71 4Q3S X7A 0.001034 0.40748 2.5974
72 1ML4 PAL 0.002475 0.40528 2.5974
73 2YHW BM3 0.0004574 0.40053 2.62391
74 4B16 NAG 0.009452 0.45565 2.63158
75 4B9E FAH 0.001438 0.4735 2.65781
76 1ULE GLA GAL NAG 0.02616 0.41811 2.66667
77 1EB9 HBA 0.001185 0.44029 2.67176
78 1FBL HTA 0.00006469 0.49727 2.68657
79 3L24 GOA 0.003888 0.4678 2.68657
80 2ZJF BSU 0.0007819 0.45289 2.68657
81 4C2G ALA ALA ALA ALA 0.001138 0.45174 2.68657
82 3L6R MLI 0.005818 0.44416 2.68657
83 4WBD CIT 0.01198 0.43526 2.68657
84 3U1T MLI 0.0091 0.43475 2.68657
85 4KCT FDP 0.001763 0.43342 2.68657
86 4WBD ADP 0.01178 0.42931 2.68657
87 4KCT PYR 0.004434 0.42676 2.68657
88 1WDA BAG 0.005429 0.42304 2.68657
89 3NYQ AMP 0.0002492 0.41245 2.68657
90 1I2B UPG 0.001557 0.40986 2.68657
91 1I2B USQ 0.001557 0.40986 2.68657
92 1I2B NAD 0.001557 0.40986 2.68657
93 3NYQ MCA 0.0002813 0.4095 2.68657
94 1K6M AGS 0.00253 0.40321 2.68657
95 4NAO AKG 0.0009858 0.48141 2.76074
96 1B4P GPS 0.001962 0.41437 2.76498
97 1A27 EST 0.001059 0.43261 2.76817
98 3GJB AKG 0.001691 0.44448 2.82132
99 2Y7G AAE 0.001691 0.42494 2.83688
100 1EYE PMM 0.001985 0.43136 2.85714
101 4ZS4 ATP 0.001166 0.48189 2.9316
102 4M5P MLA 0.001713 0.49609 2.98507
103 4WVH ASP HIS ASP ALA HIS ALA 0.001993 0.44146 2.98507
104 4M5P 23W 0.01331 0.43296 2.98507
105 3QV9 QV7 0.006121 0.4311 2.98507
106 3F3E LEU 0.0000952 0.43012 2.98507
107 2YFT DQR 0.002689 0.41735 2.98507
108 4LHM AZZ 0.01234 0.41733 2.98507
109 3BRE C2E 0.01974 0.41303 2.98507
110 1SJD NPG 0.0006145 0.41294 2.98507
111 2BH9 NAP 0.003716 0.41205 2.98507
112 4M5P FMN 0.00258 0.40293 2.98507
113 3GE7 AFQ 0.000538 0.40284 2.98507
114 1TFZ 869 0.003312 0.40266 2.98507
115 2Z9C FMN 0.002887 0.40474 3
116 3SHR CMP 0.0008797 0.45079 3.01003
117 3I8T LBT 0.01946 0.40377 3.04878
118 1EYQ NAR 0.002977 0.43408 3.15315
119 3F8C HT1 0.005448 0.43339 3.1746
120 2Y7P SAL 0.009067 0.41832 3.21101
121 4JWX 1N4 0.01748 0.40581 3.21429
122 2DWU DGL 0.01264 0.40746 3.26087
123 2YDW WSH 0.001205 0.44518 3.26797
124 1Y1A GSH 0.016 0.45545 3.27869
125 2XDQ MGX 0.01235 0.44154 3.28358
126 4RJK PYR 0.0304 0.41481 3.28358
127 3Q9T FAY 0.00058 0.40826 3.28358
128 3DER ALA LYS 0.002858 0.40489 3.28358
129 1KYZ SAH 0.004815 0.40041 3.28358
130 4TMK T5A 0.009146 0.40956 3.28639
131 1UCN ADP 0.002413 0.42343 3.28947
132 3GTD MLI 0.0005557 0.47806 3.3195
133 2V6O FAD 0.003116 0.41132 3.3557
134 3W8S GSH 0.007565 0.42695 3.39806
135 1MZV AMP 0.001535 0.44087 3.40426
136 2QCX PF1 0.0007375 0.47253 3.42205
137 1TH8 ADP 0.00385 0.42447 3.44828
138 2JAR UMP 0.002139 0.41303 3.5
139 1CBF SAH 0.001693 0.42493 3.50877
140 1RYI GOA 0.001762 0.51174 3.58209
141 1H16 PYR 0.005824 0.45102 3.58209
142 1Y9Q MED 0.003704 0.44703 3.58209
143 4W6Z ETF 0.01182 0.44254 3.58209
144 3I0O SMI 0.004683 0.43635 3.58209
145 3I0O ADP 0.003083 0.42844 3.58209
146 1H16 DTL 0.02308 0.42726 3.58209
147 1W7J ADP BEF 0.001865 0.41915 3.58209
148 1R6D NAD 0.001162 0.41302 3.58209
149 2YVF NAD 0.001868 0.41195 3.58209
150 2YVF FAD 0.001973 0.41046 3.58209
151 3CQ5 PMP 0.01285 0.40716 3.58209
152 2Q09 DI6 0.01336 0.40644 3.58209
153 4OYA 1VE 0.009565 0.40513 3.58209
154 1QZZ SAM 0.009032 0.40118 3.58209
155 1R6D DAU 0.002722 0.40063 3.58209
156 1BDB NAD 0.002493 0.41328 3.61011
157 1CKM GTP 0.0006051 0.46334 3.63636
158 4IU0 ABH 0.002472 0.40018 3.63636
159 1C1L GAL BGC 0.002689 0.46037 3.64964
160 4AF5 CIT 0.006919 0.43436 3.68421
161 1FW1 GSH 0.001169 0.43562 3.7037
162 1JH7 UVC 0.01054 0.42044 3.7037
163 1I2L DCS 0.002113 0.40946 3.71747
164 1DBT U5P 0.0002098 0.44908 3.76569
165 1BTN I3P 0.004749 0.48486 3.77358
166 3O2K DST 0.001145 0.45757 3.79747
167 3O2K QRP 0.002527 0.43198 3.79747
168 2YIV NBN 0.001269 0.47611 3.81098
169 2YIV YIV 0.01654 0.42819 3.81098
170 1H6W SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 0.001638 0.40536 3.84615
171 2FEQ 34P 0.001726 0.42038 3.861
172 2A2X NA9 0.002135 0.41306 3.861
173 2ZWS PLM 0.005495 0.47821 3.8806
174 3DGB MUC 0.0002012 0.47097 3.8806
175 3MTW M3R 0.0007349 0.43859 3.8806
176 2CE7 ADP 0.001465 0.43183 3.8806
177 1T10 F6P 0.006721 0.42927 3.8806
178 1NVV GNP 0.001148 0.40112 3.8806
179 1DXY COI 0.00457 0.46413 3.9039
180 1V6A TRE 0.004184 0.43856 3.91566
181 3ZF8 GDP 0.009129 0.40905 3.93443
182 4IXW IXW 0.004102 0.4282 3.93701
183 4JLV ADP 0.04931 0.41963 4.08922
184 1GSA ADP 0.0004965 0.41995 4.11392
185 1GSA GSH 0.0005543 0.41228 4.11392
186 3K3G MMU 0.008175 0.42281 4.11765
187 1VQ2 DDN 0.003304 0.40401 4.14508
188 1Q6O LG6 0.001704 0.42482 4.16667
189 2C7G ODP 0.003024 0.4008 4.16667
190 2C7G FAD 0.003362 0.40012 4.16667
191 2NCD ADP 0.0003782 0.48559 4.1791
192 2GWD GLU 0.0007093 0.46043 4.1791
193 1GJW GLC 0.004316 0.45043 4.1791
194 3BK2 U5P 0.001793 0.43312 4.1791
195 3A1I UNU 0.00311 0.42828 4.1791
196 2RHQ GAX 0.0004385 0.42509 4.1791
197 2HGS ADP 0.00001066 0.42497 4.1791
198 1GJW MAL 0.004247 0.42272 4.1791
199 3I51 45C 0.003338 0.42236 4.1791
200 5XHA FRU FRU 0.01064 0.40631 4.1791
201 1ZK7 FAD 0.001341 0.4048 4.1791
202 2R40 EPH 0.00005262 0.42786 4.18251
203 2ZYF AKG 0.008871 0.414 4.18848
204 1I0Z OXM 0.006674 0.45553 4.2042
205 4LO6 SIA GAL 0.01233 0.43142 4.21053
206 4IAE 1DX 0.002032 0.40501 4.2328
207 1IA9 ANP 0.004834 0.45149 4.28571
208 1L1Q 9DA 0.00003415 0.40422 4.30108
209 4Q0A 4OA 0.0004239 0.43816 4.30464
210 4E28 9MZ 0.002031 0.4592 4.30769
211 4E28 0MZ 0.003219 0.44369 4.30769
212 5RHN 8BR 0.004697 0.40821 4.34783
213 2JBH 5GP 0.001619 0.44528 4.44444
214 1B5E DCM 0.000513 0.46637 4.47154
215 1KTC NGA 0.001418 0.45351 4.47761
216 1GPJ CIT 0.005101 0.44054 4.47761
217 1MOQ GLP 0.001817 0.41556 4.47761
218 1QF5 RPL 0.001658 0.40386 4.47761
219 1QF5 GDP 0.001658 0.40386 4.47761
220 2PR5 FMN 0.00009261 0.46178 4.54545
221 1ZZ7 S0H 0.001388 0.45392 4.54545
222 1N9L FMN 0.000094 0.46155 4.58716
223 3RK0 AMP 0.0005754 0.45279 4.64135
224 2FH5 GTP 0.001788 0.41199 4.6729
225 1L3I SAH 0.0003651 0.41301 4.6875
226 1GU3 BGC BGC BGC BGC BGC 0.001269 0.4556 4.69799
227 1LTH NAD 0.0038 0.40065 4.70219
228 2QTR NXX 0.0002347 0.40473 4.7619
229 1ZS6 ADP 0.0005769 0.46422 4.77612
230 1PX8 XYP 0.003186 0.4439 4.77612
231 2Q1A 2KT 0.005101 0.44055 4.77612
232 1QO0 BMD 0.006795 0.43473 4.77612
233 3DG6 MUC 0.002058 0.42611 4.77612
234 4BG1 OGA 0.0005868 0.42479 4.77612
235 4BG1 IVL 0.0005868 0.42479 4.77612
236 1E4E PHY 0.001998 0.42221 4.77612
237 1PEA ACM 0.02884 0.41597 4.77612
238 1E4E ADP 0.003786 0.40416 4.77612
239 2XVE FAD 0.003367 0.40375 4.77612
240 2O2C G6Q 0.00635 0.40326 4.77612
241 3WE0 FAD 0.001406 0.40222 4.77612
242 4C6F DOR 0.01354 0.402 4.77612
243 4C6F NCD 0.01354 0.402 4.77612
244 2EB5 OXL 0.01227 0.42273 4.86891
245 1WRA PC 0.0001669 0.51863 4.87013
246 3BY8 MLT 0.003414 0.45536 4.92958
247 1G0N PHH 0.0007796 0.40785 4.947
248 1MXI SAH 0.003112 0.4072 5
249 3KMT SAH 0.0009565 0.439 5.04202
250 3E5H GNP 0.0006913 0.41132 5.05618
251 2C5S AMP 0.0002592 0.4789 5.07463
252 3LTW HLZ 0.001517 0.46511 5.07463
253 2Q8H TF4 0.004764 0.46319 5.07463
254 1UOU CMU 0.001297 0.43388 5.07463
255 2QF7 COA 0.005472 0.40964 5.07463
256 3K37 BCZ 0.004694 0.40774 5.07463
257 4M37 SAH 0.003733 0.40084 5.07463
258 1A8S PPI 0.01231 0.40167 5.12821
259 3L0E G58 0.0009233 0.40085 5.13834
260 3SIX GDP 0.00291 0.42474 5.15152
261 1XIU REA 0.001035 0.42854 5.21739
262 1H8G CHT 0.01536 0.45266 5.26316
263 2WMO GTP 0.004057 0.41468 5.26316
264 4J7H TLO 0.003067 0.40037 5.30786
265 4J7H TRH 0.003901 0.40017 5.30786
266 1F5F DHT 0.0007509 0.43365 5.36585
267 2ZJ5 ADP 0.003529 0.4419 5.37313
268 3GM5 CIT 0.005063 0.4407 5.37313
269 2RCN GDP 0.002578 0.43163 5.37313
270 1P1M MET 0.001019 0.41295 5.37313
271 3AKK ADP 0.04961 0.40671 5.37313
272 1V7R CIT 0.02567 0.43184 5.37634
273 2JGS BTN 0.005599 0.43011 5.38462
274 1VDC FAD 0.0005768 0.41795 5.40541
275 4JP3 CIT 0.0003117 0.46339 5.43933
276 3UEC ALA ARG TPO LYS 0.0006418 0.49041 5.47945
277 1Q3P GLU ALA GLN THR ARG LEU 0.008615 0.41454 5.50459
278 4F8L GAL 0.008377 0.46774 5.51724
279 4P4T GDP 0.001653 0.41703 5.55556
280 3QDY CBS 0.002992 0.45812 5.59441
281 3QDY A2G GAL 0.009647 0.44 5.59441
282 3QDT A2G GAL 0.01493 0.43044 5.59441
283 2IYG FMN 0.00115 0.44081 5.64516
284 1S8F GDP 0.0007073 0.44408 5.64972
285 3P3N AKG 0.00668 0.43508 5.67164
286 2WA4 069 0.001888 0.43223 5.67164
287 1FP2 SAH 0.003962 0.41508 5.67164
288 1FP2 HMO 0.003091 0.41507 5.67164
289 1C7S CBS 0.009135 0.4049 5.67164
290 1SC3 MLI 0.006395 0.44898 5.68182
291 3TFC PEP 0.009622 0.41719 5.71429
292 9LDT OXM 0.04134 0.4204 5.72289
293 1XX4 BAM 0.01149 0.41622 5.74713
294 3PXP MYR 0.004332 0.4057 5.82192
295 1SS4 GSH 0.0002171 0.56286 5.88235
296 1SS4 CIT 0.01557 0.44055 5.88235
297 3S9K CIT 0.006349 0.4971 5.9322
298 1Y75 NAG 0.0006522 0.46196 5.9322
299 2PP3 LGT 0.000173 0.46776 5.97015
300 2JC9 ADN 0.003531 0.43622 5.97015
301 4CCO OGA 0.005366 0.42828 5.97015
302 2VQ5 HBA 0.01611 0.42271 5.97015
303 4OCV ANP 0.03882 0.40665 5.97015
304 4GO7 THR 0.004016 0.42372 6
305 2FR6 CTN 0.0001442 0.4549 6.16438
306 2FR6 URI 0.00238 0.41137 6.16438
307 4HZO COA 0.0009197 0.46171 6.28931
308 2OFE NAG 0.008297 0.43068 6.33803
309 4G4S LDZ 0.001862 0.41918 6.34146
310 2VAR AMP 0.002544 0.43186 6.38978
311 2VAR KDG 0.002283 0.42894 6.38978
312 2VAR KDF 0.002767 0.42561 6.38978
313 2VAR ANP 0.001588 0.41009 6.38978
314 1EP2 ORO 0.00003679 0.43787 6.43087
315 4COQ SAN 0.001005 0.47344 6.47773
316 2QLX RM4 0.01158 0.42968 6.48148
317 2JFV FLC 0.004951 0.44115 6.52921
318 5I35 ANP 0.002967 0.46972 6.56716
319 1A59 CIT 0.00249 0.46197 6.56716
320 2HFK E4H 0.001443 0.45318 6.56716
321 1YRX FMN 0.0004545 0.45152 6.56716
322 4RPM HXC 0.02688 0.43866 6.56716
323 1A59 COA 0.000576 0.43341 6.56716
324 2PVQ GSH 0.001647 0.42113 6.56716
325 4IHQ ADP 0.006804 0.41889 6.56716
326 1A5Z OXM 0.02816 0.41649 6.58307
327 1ZP9 ATP 0.04815 0.40738 6.58915
328 2BZ1 TAU 0.002658 0.49623 6.63265
329 2WCI GSH 0.006212 0.43081 6.66667
330 4U9W COA 0.00281 0.41261 6.76329
331 4OB6 S2T 0.0002337 0.45734 6.86567
332 4R33 SAH 0.000578 0.40195 6.86567
333 4R33 TRP 0.000578 0.40195 6.86567
334 1WGC SIA GAL BGC 0.001884 0.49385 7.01754
335 2WGC SIA GAL BGC 0.006332 0.4747 7.01754
336 1Y2W NAG 0.02168 0.41112 7.04225
337 4DN8 BMA 0.02343 0.40953 7.05128
338 2Q2V NAD 0.00009458 0.41574 7.05882
339 4JHG ZEA 0.001384 0.42823 7.14286
340 2P8O BVA 0.001197 0.42622 7.2165
341 1NU4 MLA 0.04642 0.4176 7.2165
342 4DYO SD4 0.003819 0.42951 7.46269
343 2BII MTV 0.0008684 0.41165 7.46269
344 4AXD ANP 0.00006515 0.40025 7.46269
345 3OND ADN 0.002193 0.40012 7.46269
346 3OND NAD 0.002193 0.40012 7.46269
347 1UW1 ADP 0.001797 0.45511 7.5
348 2Q37 3AL 0.01026 0.42096 7.73481
349 1T0S BML 0.001229 0.48491 7.76119
350 1JQI CAA 0.0001519 0.43213 7.76119
351 1SQ5 ADP 0.002944 0.42454 7.79221
352 1SQ5 PAU 0.01825 0.40499 7.79221
353 1UF5 CDT 0.002109 0.43521 7.92079
354 3E81 SLB 0.006055 0.43132 7.92683
355 2NVK NAP 0.001526 0.45212 8.0597
356 1YOA FMN 0.002114 0.5019 8.1761
357 1Y42 TYR 0.0141 0.40991 8.35821
358 3DNT ATP 0.001796 0.40143 8.35821
359 3KJQ B94 0.004157 0.41856 8.42105
360 1JN2 SFP 0.004872 0.4855 8.43882
361 3RF4 FUN 0.004073 0.43351 8.62069
362 3MD0 GDP 0.003303 0.43218 8.65672
363 1T0I FMN 0.002323 0.41175 8.90052
364 2FFC U5P 0.002161 0.41287 8.95522
365 1G8S MET 0.002662 0.45372 9.13043
366 3BHO B4P 0.009515 0.45549 9.13461
367 3PLN U5P 0.002769 0.44083 9.25373
368 2NLI LAC 0.003796 0.40067 9.25373
369 1Y7P RIP 0.03154 0.41399 9.41704
370 2YLD CMO 0.005326 0.43967 9.44882
371 2BKK ADP 0.03974 0.41796 9.4697
372 4OUC 5ID 0.009178 0.44829 9.55224
373 4JCA CIT 0.0123 0.44939 9.58084
374 3CH5 GDP 0.01204 0.40009 9.61539
375 1TUV VK3 0.01538 0.43654 9.64912
376 3F81 STT 0.003628 0.46937 9.83607
377 3WO0 ADP 0.0001055 0.42745 9.85075
378 3WO0 ALA 0.0001055 0.42745 9.85075
379 2ZSC BTN 0.0007642 0.44278 9.92908
380 3TDV GDP 0.03589 0.41113 10.4575
381 4G28 0W8 0.0005745 0.46429 10.7843
382 1UXG NAD 0.0001391 0.42658 11.0032
383 1UXG FUM 0.0001391 0.42658 11.0032
384 3Q60 ATP 0.00457 0.46012 11.3433
385 3X01 AMP 0.04762 0.42479 11.4504
386 2E1A MSE 0.000378 0.47197 12
387 4EXO PYR 0.004913 0.45473 12.3288
388 3KPE TM3 0.0266 0.40693 12.8205
389 3VPD ANP 0.000001599 0.43891 13.1673
390 2FOI JPA 0.003409 0.42664 13.3333
391 4LWM MHO 0.02477 0.43908 13.3641
392 3CF6 SP1 0.001518 0.42671 13.7725
393 3T1A 5MA 0.00009793 0.46091 14.0299
394 3SJ0 DXC 0.01215 0.42866 14.0845
395 2BOI MFU 0.004911 0.42996 14.1593
396 4JEJ 1GP 0.001273 0.43905 14.3443
397 2V5E SCR 0.002139 0.49084 14.5
398 4NTX AMR 0.002931 0.44259 15
399 1EDO NAP 0.00546 0.4009 15.1639
400 1ZJ6 G3D 0.001716 0.43388 17.6471
401 1XE7 GUN 0.01967 0.43091 19.7044
402 4Y93 746 0.0004555 0.48195 22.3881
403 1U59 STU 0.0002247 0.52189 22.6481
404 5U6C 7YS 0.0002237 0.50807 22.8571
405 1ECM TSA 0.00008025 0.50041 22.9358
406 3PP0 03Q 0.02113 0.40442 23.8806
407 5X8I SQZ 0.0006441 0.49898 24.1791
408 2VKL MLT 0.04898 0.4163 24.4444
409 4OAV ACP 0.00006671 0.55394 24.7761
410 3TTI KBI 0.001319 0.45487 27.4627
411 5AWM ANP 0.01522 0.44433 28.3582
412 3ORK AGS 0.0005505 0.47825 28.6174
413 5LPZ ADP 0.000007089 0.59708 28.9157
414 4KBA 1QM 0.03738 0.41617 29.2537
415 3E8N ATP 0.00000000004332 0.51615 29.6188
416 3E8N VRA 0.00000000004332 0.51615 29.6188
417 4EUU BX7 0.00313 0.44132 30.094
418 3GC0 AMP 0.0006563 0.51329 30.1493
419 3FHR P4O 0.01102 0.43384 30.4478
420 2CSN CKI 0.000006115 0.43888 30.7463
421 5DMZ ADP 0.01335 0.43289 31.3433
422 5HX8 66P 0.00156 0.45473 31.457
423 5JGA 6KC 0.002518 0.43205 31.746
424 2XVD AS6 0.0003331 0.47756 32.4503
425 2BPM 529 0.00009409 0.45181 32.6861
426 4EWH T77 0.00583 0.42671 33.0909
427 1BYG STU 0.000946 0.49983 33.0935
428 4AT3 LTI 0.00865 0.41446 33.1104
429 4BCN T9N 0.0001487 0.54762 33.6667
430 4E93 GUI 0.0003308 0.46821 33.7313
431 5NKB 8ZT 0.003987 0.40703 33.7313
432 4CRL C1I 0.0061 0.41405 34.0299
433 3CY2 MB9 0.0004425 0.49003 34.3949
434 5T8O 76Z 0.002658 0.46061 34.9254
435 1V0O INR 0.001506 0.47641 35.0694
436 4NM5 ADP 0.000000000008585 0.68068 35.2239
437 3VRY B43 0.003179 0.44394 35.2239
438 1O9U ADZ 0.0000000001614 0.85264 35.5224
439 4CFU 2WC 0.0001058 0.54943 36.1194
440 3TXO 07U 0.00000001309 0.45706 36.1194
441 2R5T ANP 0.002112 0.40588 36.1194
442 3EKK GS2 0.0006391 0.44579 36.1564
443 1Y57 MPZ 0.00005028 0.53402 36.4179
444 3PVW QRX 0.0002906 0.48706 36.4179
445 2H8H H8H 0.001894 0.4755 36.4179
446 3LXN MI1 0.001489 0.47276 36.7164
447 3KRL KRL 0.003682 0.45039 36.7164
448 1XJD STU 0.00566 0.44811 37.0149
449 4UAL 3FV 0.002206 0.41647 37.0149
450 4NST AF3 0.000004721 0.63535 37.3134
451 4NST ADP 0.0005189 0.50368 37.3134
452 3C0G 3AM 0.001575 0.49303 37.6119
453 5VCV 1N1 0.00004326 0.53242 37.6206
454 4YMJ 4EJ 0.0004819 0.54303 37.8289
455 3UIM ANP 0.00009821 0.5399 37.9104
456 2WQN ADP 0.001605 0.4926 37.9104
457 4X7Q 3YR 0.002153 0.47271 38.141
458 4OTH DRN 0.0002099 0.50938 38.209
459 3PLS ANP 0.000001656 0.63594 38.255
460 4GJ3 0XP 0.0004429 0.46599 38.4106
461 1K3A ACP 0.0001901 0.54193 38.4615
462 5LI9 ACP 0.001452 0.47719 38.5075
463 4BHN BH9 0.0005333 0.49429 38.6228
464 4XLI 1N1 0.005258 0.457 38.806
465 2OFV 242 0.007582 0.4061 38.9892
466 5USZ SKE 0.000399 0.47752 39.1003
467 2PVF ACP 0.0003132 0.51963 39.403
468 4UX9 ANP 0.000192 0.51569 39.403
469 4IZY 1J2 0.001907 0.46757 39.403
470 3IGO ANP 0.002299 0.4601 39.403
471 3GQI ACP 0.0005889 0.50093 39.7015
472 3GC8 B45 0.001408 0.47019 39.7015
473 4E1Z 0MX 0.004789 0.44183 39.8625
474 2F57 23D 0.0004417 0.51708 40
475 4BFM ANP 0.00002497 0.55844 40.1198
476 1U5R ATP 0.00000000001106 0.73331 40.2985
477 5DH3 5BS 0.0006286 0.49084 40.3175
478 2XK9 XK9 0.0000000006933 0.57444 40.3727
479 2VZ6 FEF 0.01906 0.43518 40.5751
480 3V8S 0HD 0.002192 0.47644 40.597
481 2B9I ADP 0.002521 0.46927 40.597
482 2YAB AMP 0.0005409 0.49828 40.8955
483 2F2U M77 0.000231 0.4746 40.8955
484 3HZT J60 0.01768 0.44075 41.194
485 5DRB 5FJ 0.003166 0.40333 41.2371
486 4H3P ANP 0.00001158 0.5864 41.4925
487 4WB7 ATP 0.002454 0.42539 41.4925
488 4QMN DB8 0.00004528 0.49349 41.6129
489 3IDB ANP 0.0001297 0.51485 41.791
490 2X4Z X4Z 0.001271 0.43908 41.8919
491 4Y8D 49J 0.02114 0.42281 42.0896
492 4C2V YJA 0.01598 0.40314 42.1053
493 2J7T 274 0.00000002533 0.51643 43.0464
494 5H2U 1N1 0.008196 0.44356 43.0712
495 5DA3 58V 0.002086 0.49143 43.3962
496 2HY0 306 0.003324 0.47575 43.4783
497 4KS7 X4Z 0.0002278 0.50346 43.4931
498 4NW6 2NS 0.0003423 0.4676 43.9628
499 4WNP 3RJ 0.0001187 0.55282 45.2962
500 2YAK OSV 0.00003796 0.51415 45.9649
501 2WEI VGG 0.00657 0.45589 45.993
502 2A19 ANP 0.0001809 0.54923 46.831
503 5L8L ADP 0.00003552 0.58769 47.0175
504 5G1X ADP 0.0001269 0.53967 47.0175
505 5LXM ADP 0.0001098 0.54288 47.3498
506 5UOX 8GY 0.0006211 0.48705 47.6015
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