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Receptor
PDB id Resolution Class Description Source Keywords
5ABX 1.66 Å NON-ENZYME: TRANSCRIPT_TRANSLATE COMPLEX OF C. ELEGANS EIF4E-3 WITH THE 4E-BINDING PROTEIN MEXTLI AND CAP ANALOG CAENORHABDITIS ELEGANS TRANSLATION GENE REGULATION CAP BINDING PROTEIN 4E BINDIN
Ref.: MEXTLI PROTEINS USE BOTH CANONICAL BIPARTITE AND NO TRIPARTITE BINDING MODES TO FORM EIF4E COMPLEXES TH DISPLAY DIFFERENTIAL SENSITIVITY TO 4E-BP REGULATIO GENES DEV. V. 29 1835 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MGP A:1216;
Valid;
none;
submit data
538.215 C11 H19 N5 O14 P3 C[n+]...
ZN B:1508;
B:1509;
A:1217;
A:1218;
Part of Protein;
Invalid;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
65.409 Zn [Zn+2...
CL A:1219;
Invalid;
none;
submit data
35.453 Cl [Cl-]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5ABX 1.66 Å NON-ENZYME: TRANSCRIPT_TRANSLATE COMPLEX OF C. ELEGANS EIF4E-3 WITH THE 4E-BINDING PROTEIN MEXTLI AND CAP ANALOG CAENORHABDITIS ELEGANS TRANSLATION GENE REGULATION CAP BINDING PROTEIN 4E BINDIN
Ref.: MEXTLI PROTEINS USE BOTH CANONICAL BIPARTITE AND NO TRIPARTITE BINDING MODES TO FORM EIF4E COMPLEXES TH DISPLAY DIFFERENTIAL SENSITIVITY TO 4E-BP REGULATIO GENES DEV. V. 29 1835 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 5ABX - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 5ABX - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 5ABX - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MGP; Similar ligands found: 81
No: Ligand ECFP6 Tc MDL keys Tc
1 MGP 1 1
2 6G0 0.986667 1
3 G7M 0.794872 0.987013
4 GTG 0.741935 0.974684
5 GTA 0.71875 0.974684
6 MG7 0.653846 0.884615
7 GTP 0.619565 0.961039
8 MGO 0.619565 0.901235
9 GDP 7MG 0.592233 0.949367
10 GP3 0.55914 0.936709
11 GDP 0.553191 0.961039
12 GSP 0.525253 0.91358
13 MGQ 0.514852 0.925
14 G1R 0.5 0.948718
15 MGV 0.5 0.880952
16 GAV 0.5 0.925
17 GNH 0.5 0.948718
18 01G 0.495327 0.870588
19 9GM 0.49505 0.936709
20 GNP 0.49505 0.936709
21 HFD 0.494845 0.841463
22 HEJ 0.494737 0.884615
23 ATP 0.494737 0.884615
24 AQP 0.489583 0.884615
25 5FA 0.489583 0.884615
26 GCP 0.485149 0.936709
27 G5P 0.477477 0.936709
28 7DT 0.474227 0.871795
29 G2R 0.471698 0.925
30 5GP 0.46875 0.948052
31 G 0.46875 0.948052
32 ITT 0.46875 0.835443
33 G3A 0.468468 0.936709
34 0O2 0.46729 0.948052
35 AJQ 0.466102 0.926829
36 GKE 0.463636 0.925
37 GDC 0.463636 0.925
38 GDD 0.463636 0.925
39 Y9Z 0.463636 0.892857
40 GMV 0.460784 0.936709
41 GFB 0.459459 0.949367
42 GDR 0.459459 0.949367
43 DGT 0.456311 0.888889
44 GPD 0.45614 0.914634
45 6CK 0.455357 0.902439
46 G2P 0.451923 0.925
47 AP5 0.447917 0.860759
48 B4P 0.447917 0.860759
49 GKD 0.447368 0.925
50 JB2 0.447368 0.949367
51 8GT 0.445545 0.843373
52 NGD 0.445378 0.949367
53 GPG 0.440367 0.925
54 BA3 0.4375 0.860759
55 GH3 0.433962 0.935897
56 ADP 0.43299 0.884615
57 6YZ 0.432692 0.8625
58 GP2 0.431373 0.925
59 GDX 0.431034 0.936709
60 YGP 0.428571 0.891566
61 MGT 0.428571 0.837209
62 RGT 0.428571 0.875
63 IDP 0.425743 0.935065
64 JB3 0.425 0.9375
65 A4P 0.425 0.83908
66 CAG 0.424 0.894118
67 25L 0.423423 0.873418
68 A2D 0.416667 0.860759
69 7DD 0.414141 0.871795
70 6AD 0.413462 0.855422
71 SAP 0.411765 0.841463
72 AGS 0.411765 0.841463
73 G3D 0.411215 0.948052
74 G2Q 0.409091 0.925
75 ALF 5GP 0.40566 0.879518
76 TPG 0.40458 0.853933
77 ACQ 0.403846 0.8625
78 ANP 0.403846 0.8625
79 G4P 0.40367 0.948052
80 C1Z 0.401786 0.948052
81 2MD 0.4 0.860465
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5ABX; Ligand: MGP; Similar sites found with APoc: 105
This union binding pocket(no: 1) in the query (biounit: 5abx.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 2P0D I3P None
2 5O9W AKG 2.10526
3 2X3F APC 2.10526
4 3IA4 NDP 2.46914
5 5KMS NAD 2.63158
6 5KMS FAD 2.63158
7 1AOE NDP 2.63158
8 1AOE GW3 2.63158
9 2RAB NAD 3.15789
10 2HSA FMN 3.15789
11 1GAH ACR 3.15789
12 5ML3 DL3 3.3557
13 2QUN FUD 3.68421
14 6EOZ 58K 3.68421
15 3MF2 AMP 3.68421
16 1P1C SAH 3.68421
17 3IX9 NDP 3.68421
18 2TPS TPS 4.21053
19 5A04 BGC 4.21053
20 5A04 NDP 4.21053
21 2GGH NLQ 4.21053
22 4I9A NCN 4.21053
23 4DYG MES 4.21053
24 1VJ7 GDP 4.21053
25 2YVJ FAD 4.73684
26 2CDU FAD 5.26316
27 2W9S NDP 5.59006
28 2DW7 SRT 5.78947
29 2YJ0 420 5.7971
30 2ZHL NAG GAL GAL NAG 6.08108
31 4QT2 RAP 6.10687
32 3HIW C2X 6.31579
33 2Z8G GLC GLC BGC 6.31579
34 3RG9 WRA 6.31579
35 3RG9 NDP 6.31579
36 1RPN NDP 6.31579
37 1U72 MTX 6.45161
38 1U72 NDP 6.45161
39 2WPF WPF 7.31707
40 2WPF FAD 7.31707
41 1XCL SAH 7.31707
42 3O84 HTJ 7.36842
43 5KVA SAM 7.89474
44 4JJF N2I 7.89474
45 4JJF FE9 7.89474
46 4LAY I63 8.42105
47 1GP6 SIN 8.42105
48 1GP6 QUE 8.42105
49 1GP6 DH2 8.42105
50 5JWC FAD 8.94737
51 4C12 UML 8.94737
52 5VN0 NAI 9.47368
53 5VN0 FAD 9.47368
54 4OCT AKG 9.47368
55 1MO9 FAD 9.7561
56 1MO9 KPC 9.7561
57 4RPL 3UC 9.7561
58 4RPL FAD 9.7561
59 2FHF GLC GLC GLC GLC 9.7561
60 1ULV ACR 9.7561
61 3C2O NTM 10
62 4J4H 1J1 10.5263
63 1Q3A NGH 10.9091
64 5C3R HMU 11.0526
65 5C3R AKG 11.0526
66 4EMJ FAD 11.215
67 3COW 52H 12.1053
68 5G3U ITW 12.1951
69 3DFR NDP 12.1951
70 1N7G NDP 12.6316
71 1HFS L04 14.375
72 5ESO TDP 14.6341
73 5ESO ISC 14.6341
74 5WM2 AMP 14.6341
75 5WM2 SAL 14.6341
76 1LF9 ACR 14.6341
77 4NMC FAD 14.6341
78 4NMC 2OP 14.6341
79 1RZM E4P 14.6341
80 2YB9 HA0 14.6341
81 5HUA FK5 16.5217
82 5JE8 NAD 17.0732
83 5SWB NAG BMA MAN MAN MAN MAN 17.0732
84 1OVD ORO 17.0732
85 1OVD FMN 17.0732
86 2Q3O FMN 17.8947
87 4EIL NDP 19.5122
88 5LUN ARG 19.5122
89 5LUN OGA 19.5122
90 3WDM ADN 20
91 1GET NAP 21.9512
92 1GET FAD 21.9512
93 2IVF MGD 21.9512
94 5VZ0 2BA 21.9512
95 1MZC FPP 21.9512
96 1MZC BNE 21.9512
97 5CPR 539 22.6316
98 5NA1 FAD 24.2105
99 2GTE VA 26.8293
100 3C3N FMN 29.2683
101 2WLG SOP 31.7073
102 5KD6 6C7 31.7073
103 5MGD GLC GAL GAL 34.1463
104 3E3U NVC 39.0244
105 1PJS NAD 39.0244
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