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Receptor
PDB id Resolution Class Description Source Keywords
5AE9 2.44 Å EC: 2.7.1.153 CRYSTAL STRUCTURE OF MOUSE PI3 KINASE DELTA IN COMPLEX WITH GSK2292767 MUS MUSCULUS TRANSFERASE
Ref.: OPTIMIZATION OF NOVEL INDAZOLES AS HIGHLY POTENT AN SELECTIVE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE G THE TREATMENT OF RESPIRATORY DISEASE. J.MED.CHEM. V. 58 7381 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
OKO A:4000;
Valid;
none;
Ki = 0.0794 nM
512.581 C24 H28 N6 O5 S C[C@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5AE9 2.44 Å EC: 2.7.1.153 CRYSTAL STRUCTURE OF MOUSE PI3 KINASE DELTA IN COMPLEX WITH GSK2292767 MUS MUSCULUS TRANSFERASE
Ref.: OPTIMIZATION OF NOVEL INDAZOLES AS HIGHLY POTENT AN SELECTIVE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE G THE TREATMENT OF RESPIRATORY DISEASE. J.MED.CHEM. V. 58 7381 2015
Members (17)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2WXP ic50 = 3 nM GD9 C23 H27 N7 O3 S2 CS(=O)(=O)....
2 2WXL ic50 = 4.6 nM ZS4 C19 H21 F2 N7 O2 c1ccc2c(c1....
3 2WXO ic50 = 90 nM ZZP C22 H19 F N4 O4 S COC1=CC(=C....
4 6Q74 - HKN C22 H24 N4 O4 S Cc1nc(cn1C....
5 5T2B ic50 = 5 nM 74O C19 H18 N8 Cn1c(nc(n1....
6 2WXF ic50 = 180 nM 039 C21 H15 Cl N6 O2 S COc1ccccc1....
7 6FTN ic50 = 200 nM E78 C20 H23 N3 O2 S Cc1cc(cc2c....
8 5NCZ ic50 = 0.79 nM 8TN C24 H25 N7 O S CC1=CSC2=C....
9 4XE0 ic50 = 19 nM 40L C22 H18 F N7 O CC[C@@H](C....
10 2X38 ic50 = 130 nM IC8 C22 H19 N7 O Cc1ccccc1N....
11 5AE9 Ki = 0.0794 nM OKO C24 H28 N6 O5 S C[C@@H]1CN....
12 5AE8 Ki = 0.126 nM VVX C26 H28 N6 O CC(C)N1CCN....
13 6Q73 - HKK C11 H13 Cl N2 O3 S CS(=O)(=O)....
14 5T2I ic50 = 2 nM 74J C20 H19 N9 O Cn1c(nc(n1....
15 2WXG ic50 = 0.7 nM ZZN C28 H22 F N7 O2 Cc1ccccc1N....
16 5NCY ic50 = 0.4 nM 8TK C21 H18 N6 O S CC1=CSC2=C....
17 6Q6Y - HKQ C17 H13 Cl N2 O2 S c1ccc(cc1)....
70% Homology Family (18)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2WXP ic50 = 3 nM GD9 C23 H27 N7 O3 S2 CS(=O)(=O)....
2 2WXL ic50 = 4.6 nM ZS4 C19 H21 F2 N7 O2 c1ccc2c(c1....
3 2WXO ic50 = 90 nM ZZP C22 H19 F N4 O4 S COC1=CC(=C....
4 6Q74 - HKN C22 H24 N4 O4 S Cc1nc(cn1C....
5 5T2B ic50 = 5 nM 74O C19 H18 N8 Cn1c(nc(n1....
6 2WXF ic50 = 180 nM 039 C21 H15 Cl N6 O2 S COc1ccccc1....
7 6FTN ic50 = 200 nM E78 C20 H23 N3 O2 S Cc1cc(cc2c....
8 5NCZ ic50 = 0.79 nM 8TN C24 H25 N7 O S CC1=CSC2=C....
9 4XE0 ic50 = 19 nM 40L C22 H18 F N7 O CC[C@@H](C....
10 2X38 ic50 = 130 nM IC8 C22 H19 N7 O Cc1ccccc1N....
11 5AE9 Ki = 0.0794 nM OKO C24 H28 N6 O5 S C[C@@H]1CN....
12 5AE8 Ki = 0.126 nM VVX C26 H28 N6 O CC(C)N1CCN....
13 6Q73 - HKK C11 H13 Cl N2 O3 S CS(=O)(=O)....
14 5T2I ic50 = 2 nM 74J C20 H19 N9 O Cn1c(nc(n1....
15 2WXG ic50 = 0.7 nM ZZN C28 H22 F N7 O2 Cc1ccccc1N....
16 5NCY ic50 = 0.4 nM 8TK C21 H18 N6 O S CC1=CSC2=C....
17 6Q6Y - HKQ C17 H13 Cl N2 O2 S c1ccc(cc1)....
18 6EZ6 - C5Z C26 H30 N6 O4 CC(C)N1CCN....
50% Homology Family (41)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2WXP ic50 = 3 nM GD9 C23 H27 N7 O3 S2 CS(=O)(=O)....
2 2WXL ic50 = 4.6 nM ZS4 C19 H21 F2 N7 O2 c1ccc2c(c1....
3 2WXO ic50 = 90 nM ZZP C22 H19 F N4 O4 S COC1=CC(=C....
4 6Q74 - HKN C22 H24 N4 O4 S Cc1nc(cn1C....
5 5T2B ic50 = 5 nM 74O C19 H18 N8 Cn1c(nc(n1....
6 2WXF ic50 = 180 nM 039 C21 H15 Cl N6 O2 S COc1ccccc1....
7 6FTN ic50 = 200 nM E78 C20 H23 N3 O2 S Cc1cc(cc2c....
8 5NCZ ic50 = 0.79 nM 8TN C24 H25 N7 O S CC1=CSC2=C....
9 4XE0 ic50 = 19 nM 40L C22 H18 F N7 O CC[C@@H](C....
10 2X38 ic50 = 130 nM IC8 C22 H19 N7 O Cc1ccccc1N....
11 5AE9 Ki = 0.0794 nM OKO C24 H28 N6 O5 S C[C@@H]1CN....
12 5AE8 Ki = 0.126 nM VVX C26 H28 N6 O CC(C)N1CCN....
13 6Q73 - HKK C11 H13 Cl N2 O3 S CS(=O)(=O)....
14 5T2I ic50 = 2 nM 74J C20 H19 N9 O Cn1c(nc(n1....
15 2WXG ic50 = 0.7 nM ZZN C28 H22 F N7 O2 Cc1ccccc1N....
16 5NCY ic50 = 0.4 nM 8TK C21 H18 N6 O S CC1=CSC2=C....
17 6Q6Y - HKQ C17 H13 Cl N2 O2 S c1ccc(cc1)....
18 4FUL - 0VU C22 H23 N5 O3 S c1cc(cc(c1....
19 4ANW ic50 = 18 nM O92 C18 H14 Cl F2 N5 O3 S CNC(=O)c1c....
20 4WWP ic50 = 0.12 uM 3VE C22 H18 Cl N7 Cc1c(cccn1....
21 6AUD - BWY C25 H34 N6 O2 S CC(C)n1c(n....
22 4ANV ic50 = 441 nM 751 C28 H28 N4 O4 S COc1ccc(cc....
23 5JHB Kd = 873 nM 6K5 C18 H21 Cl F3 N7 O2 c1c(c(cnc1....
24 5G55 - 3QH C20 H18 N4 O Cc1ccc(cc1....
25 1E7V - LY2 C19 H17 N O3 c1ccc(cc1)....
26 2CHX - 090 C18 H16 N5 O3 COc1ccc2c(....
27 4WWO ic50 = 0.038 uM 3VD C22 H16 Cl F N6 C[C@@H](c1....
28 1E8Z - STU C28 H26 N4 O3 C[C@@]12[C....
29 3R7Q ic50 = 0.108 uM FAV C19 H14 Cl N O2 S CN(c1ccccc....
30 4GB9 - 0WR C28 H39 N9 O2 CC(C)(C1CC....
31 3ENE Ki = 0.57 uM NPZ C16 H13 N5 Cn1c2c(c(n....
32 3LJ3 ic50 = 43 nM WYE C22 H22 N4 O4 Cn1cc(c2c1....
33 2V4L ic50 = 1.5 uM ABJ C14 H15 N5 O CC(C)n1c2c....
34 6C1S Ki = 0.004 uM EFV C19 H16 N6 O3 COc1cc(cnc....
35 4HVB - 19P C24 H26 N6 O3 Cc1ccc(cn1....
36 1E8W - QUE C15 H10 O7 c1cc(c(cc1....
37 1E8X - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
38 3ZVV ic50 = 915 uM XAZ C8 H10 N4 Cc1cc(n2c(....
39 6EZ6 - C5Z C26 H30 N6 O4 CC(C)N1CCN....
40 5UBR - 85S C26 H30 N8 O2 CC(=O)N1CC....
41 5DXT Ki = 0.2 nM 5H5 C19 H22 N6 O3 C[C@@H](C(....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OKO; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 OKO 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5AE9; Ligand: OKO; Similar sites found with APoc: 563
This union binding pocket(no: 1) in the query (biounit: 5ae9.bio1) has 43 residues
No: Leader PDB Ligand Sequence Similarity
1 2HO2 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU None
2 6E2B PT7 None
3 4FL3 ANP 1.41732
4 4PTN PYR 1.45773
5 5L2R MLA 1.49007
6 5EXK 5AD 1.51057
7 5EXK MET 1.51057
8 1KJ8 ATP 1.53453
9 5EO8 TFU 1.60772
10 1PK8 ATP 1.65877
11 2JLD AG1 1.66667
12 5FYR INS 1.67785
13 3N75 G4P 1.67832
14 5MW8 ATP 1.69851
15 2ZWS PLM 1.70279
16 2CFM AMP 1.78253
17 1I1E DM2 1.78295
18 4NM5 ADP 1.85676
19 4DFU QUE 1.86335
20 5WXU FLC 1.87891
21 3ZRM ZRM 1.88679
22 5Z3I ADE 1.88679
23 4Z87 GDP 1.90476
24 4P5Z Q7M 1.93906
25 4O1P ANP 1.95258
26 2IRY DGT 1.9802
27 3TXO 07U 1.983
28 2QK4 ATP 1.99115
29 2VPQ ANP 1.99557
30 2YRX AMP 1.99557
31 3F7Z 34O 2
32 1O9U ADZ 2
33 3HMO STU 2.04678
34 3CH8 PRO GLN PRO VAL ASP SER TRP VAL 2.05128
35 3V4S ATP 2.06718
36 3PP0 03Q 2.07101
37 1U6R ADP 2.10526
38 1CKM GTP 2.12121
39 4JR7 GNP 2.13904
40 4OKD GLC GLC GLC 2.14286
41 3OPT AKG 2.14477
42 4FF8 14S 2.16718
43 2XK9 XK9 2.17391
44 1O68 KIV 2.18182
45 3VSV XYS 2.19436
46 5CKW ANP 2.21729
47 5N87 N66 2.23642
48 4OUC 5ID 2.2409
49 6G34 5ID 2.2409
50 1AUX AGS 2.2508
51 3ETH ATP 2.25352
52 5JFS 6K0 2.27273
53 3EKK GS2 2.28013
54 4IX4 ADP 2.28571
55 3BU5 ATP 2.28758
56 5MJA 7O3 2.29508
57 2XVD AS6 2.31788
58 1ZTH ADP 2.32558
59 3RE4 TO1 2.32558
60 1ZP9 ATP 2.32558
61 3E8N ATP 2.34604
62 3E8N VRA 2.34604
63 1PHK ATP 2.34899
64 2Z3U CRR 2.35294
65 5JZJ AN2 2.3569
66 6F3G CJN 2.37288
67 4WOE ADP 2.3743
68 3ORQ ADP 2.38727
69 3KRL KRL 2.38806
70 1Q8Y ADE 2.41287
71 1Q8Y ADP 2.41287
72 3AQT RCO 2.44898
73 6GN6 MAL 2.46085
74 5HGZ MLA 2.46914
75 4EIL CB3 2.4735
76 4ONA UW1 2.47934
77 3PN1 IVH 2.51572
78 4GYI ADP 2.51889
79 4DC2 ADE 2.52525
80 4WTV ATP 2.52918
81 5U6C 7YS 2.53968
82 4D52 GXL 2.53968
83 4D52 GIV 2.53968
84 4MJ0 BGC SIA SIA GAL 2.54545
85 5DZT AMP 2.55319
86 4ZH7 FUC GAL NAG GAL FUC 2.57827
87 3VOT ADP 2.58824
88 2YW2 ATP 2.59434
89 3O01 DXC 2.5974
90 5HES 032 2.60586
91 1OBD ATP 2.61438
92 3B6R ADP 2.62467
93 3B6R CRN 2.62467
94 3SLS ANP 2.63158
95 4OTH DRN 2.6393
96 2PZI AXX 2.64317
97 3PE2 E1B 2.67062
98 3FHR P4O 2.67857
99 4XJ6 GH3 2.7027
100 1JJE BYS 2.7027
101 5EH0 5NW 2.71318
102 5EQY 5RA 2.74314
103 2Y6O 1N1 2.74914
104 5USZ SKE 2.76817
105 2YAB AMP 2.77008
106 4LH7 1X8 2.78638
107 5O5Y GLC 2.80172
108 5LI1 ANP 2.82486
109 4CC6 L5Y 2.83019
110 2B9H ADP 2.83286
111 2B9J ADP 2.83286
112 2B9I ADP 2.83286
113 5HZX 2GE 2.84091
114 4FG8 ATP 2.85714
115 4WHZ 3NL 2.85714
116 5LI9 ACP 2.85714
117 5Z5I XYP 2.87234
118 5VLQ ANP 2.88625
119 4RDL FUC GAL NDG FUC 2.92208
120 2R5T ANP 2.94906
121 6CGD AKN 2.95082
122 6CGD GNP 2.95082
123 4LRJ ANP 2.95858
124 4MOB ADP 3.01205
125 4UX9 ANP 3.02198
126 2PUL ACP 3.02267
127 5TKL G3H 3.0303
128 3PTG 932 3.0303
129 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 3.04348
130 5AWM ANP 3.04569
131 2ZBA ZBA 3.05011
132 2FUE M1P 3.05344
133 3NZ1 3NY 3.06513
134 3AKK ADP 3.07692
135 5VZ0 ADP 3.08511
136 4UAL 3FV 3.10263
137 2PVN P63 3.125
138 3WW2 SF6 3.125
139 3WW2 LPK 3.125
140 3C0G 3AM 3.1339
141 4D1J DGJ 3.14815
142 5OKT 9XK 3.18471
143 4BTV RB3 3.19767
144 5UR1 YY9 3.21543
145 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 3.21637
146 2JDR L20 3.21637
147 5YF9 NIO 3.24484
148 6GW4 CHO 3.25733
149 3AQV TAK 3.26087
150 4GLW NMN 3.27869
151 4GLW 0XT 3.27869
152 5DMZ ADP 3.28767
153 1ULE GLA GAL NAG 3.29787
154 1ZY5 ANP 3.30033
155 6A1G 9OL 3.33333
156 1V8B ADN 3.34029
157 3ALN ANP 3.36391
158 3LXK MI1 3.36391
159 3R4S SLB 3.386
160 3TPV ADE 3.40909
161 3DNT ATP 3.40909
162 1VRP ADP 3.41207
163 4NST ADP 3.4188
164 1U5R ATP 3.44828
165 4BS0 6NT 3.45912
166 1M0W ANP 3.46232
167 4WNP 3RJ 3.48432
168 4YZN 4K5 3.48432
169 2AF6 BRU 3.48837
170 5KBE IPH 3.49345
171 6AC9 ANP 3.51351
172 3GNI ATP 3.51906
173 4X7Q 3YR 3.52564
174 4DXD 9PC 3.53535
175 3ORK AGS 3.53698
176 6G33 5ID 3.53982
177 6FYV 3NG 3.56083
178 2V7O DRN 3.57143
179 5OMY 9YE 3.58056
180 3DLS ADP 3.58209
181 6GVZ CHO 3.60656
182 3KAL HGS 3.60721
183 4L3L 5FI 3.61842
184 5DEY 59T 3.7037
185 2DIO EOD 3.7234
186 4U98 ACP 3.74449
187 4ZGP ADP 3.75427
188 6DZN AE3 3.75587
189 5X8I SQZ 3.75723
190 3G2Y GF4 3.80228
191 2AQX ATP 3.80623
192 5HVJ ANP 3.80952
193 1UYY BGC BGC 3.81679
194 2X2M X2M 3.82166
195 3JQ3 ADP 3.82514
196 3RI1 3RH 3.83387
197 5YJS SAL 3.84615
198 2BMB PMM 3.85321
199 4RD0 GDP 3.85542
200 4BTK DTQ 3.85757
201 3TTI KBI 3.87931
202 3FC2 IBI 3.8806
203 4XDA RIB 3.8835
204 4OH4 ANP 3.9039
205 4AUA 4AU 3.90879
206 5LPZ ADP 3.91566
207 4U44 3D9 3.91566
208 1VJY 460 3.9604
209 2B9F ADP 3.96601
210 5JSP DQY 3.9801
211 3GGF GVD 3.98671
212 1RE8 BD2 4
213 2HZQ STR 4.02299
214 1ZZ7 S0H 4.0404
215 2Q7D ANP 4.04624
216 3X01 AMP 4.07125
217 3QH2 3NM 4.0724
218 3LXN MI1 4.08805
219 5TKJ ALA VAL GLY ILE GLY ALA VAL PHE 4.10959
220 2H8H H8H 4.11215
221 5COU ATP 4.11765
222 5DRB 5FJ 4.12371
223 5DH3 5BS 4.12698
224 6FYL 3NG 4.13223
225 4RFM 3P6 4.13534
226 3DAK ANP 4.13793
227 3CY2 MB9 4.14013
228 4QMN DB8 4.19355
229 4PU5 ANP 4.19426
230 4NFN 2KC 4.20712
231 5AX9 4KT 4.22078
232 5M6N 7H9 4.23729
233 6EOM ALA LYS 4.24028
234 5KO1 6UY 4.24028
235 4N70 2HX 4.26829
236 4USF 6UI 4.27632
237 5T8O 76Z 4.29799
238 6GIN IR2 4.31894
239 3GC8 B45 4.32432
240 3HAV ATP 4.34783
241 5M06 ADP 4.34783
242 3BZ3 YAM 4.34783
243 4OWK NGA 4.34783
244 3TY5 ATP 4.35835
245 3TY5 ADP 4.35835
246 4CSV STI 4.36364
247 6CQF F97 4.3771
248 5LPB ADP 4.39189
249 2QX0 PH2 4.40252
250 3I0O ADP 4.42478
251 3DRW AMP 4.43038
252 4O4F ATP 4.43548
253 5XVG 8FX 4.43686
254 6GNO XDI 4.44444
255 4KS7 X4Z 4.45205
256 5IH9 6BF 4.47761
257 5CPR 539 4.47761
258 4BHN BH9 4.49102
259 4BG4 ADP 4.49438
260 1V0O INR 4.51389
261 4RYV ZEA 4.51613
262 5J75 6GQ 4.54545
263 5ZCT ANP 4.57516
264 3TDV GDP 4.57516
265 5C1P ADP 4.57516
266 4D06 NAR 4.59364
267 1XZ3 ICF 4.5977
268 3ZW2 GLA NAG GAL FUC 4.5977
269 5YSI NCA 4.60526
270 4JGP PYR 4.60829
271 4H6B 10X 4.61538
272 4H6B 10Y 4.61538
273 4INI AMP 4.61538
274 4K33 ACP 4.61538
275 1ELI PYC 4.62725
276 4GJ3 0XP 4.63576
277 2J7T 274 4.63576
278 2HGS ADP 4.64135
279 6CMJ F6J 4.6729
280 5KJW 53C 4.68384
281 2OFV 242 4.69314
282 2XMY CDK 4.69799
283 3WVR AMP 4.69799
284 2WU6 DKI 4.72441
285 3NBC LAT 4.72973
286 2BHW NEX 4.74138
287 5TA6 79D 4.7486
288 5OCG 9R5 4.7619
289 5FIT AP2 4.7619
290 5L9B AKG 4.7619
291 4XZ3 ACP 4.78261
292 4XYM A12 4.78261
293 4BFM ANP 4.79042
294 1UNH IXM 4.79452
295 4Y0X ADP 4.8
296 5JKG 6LF 4.82315
297 1FP6 ADP 4.84429
298 6GUE FB8 4.85075
299 4ZU5 THM 4.86111
300 1Y57 MPZ 4.86726
301 5TDF ADP 4.87239
302 4OUJ LBT 4.88599
303 3K0T BGC 4.8951
304 3IT7 TLA 4.94506
305 3TKI S25 4.95356
306 5UIU 8CG 4.95356
307 4CFU 2WC 4.96183
308 2HY0 306 4.96894
309 4WW7 AMP 4.98084
310 2D6M LBT 5.03145
311 2CSN CKI 5.05051
312 1UA4 BGC 5.05494
313 1UA4 GLC 5.05494
314 6E2O S0L 5.08475
315 1SDW IYT 5.09554
316 3W0O ADP 5.15759
317 3W0O HY0 5.15759
318 1NKI PPF 5.18518
319 2YKL NLD 5.18868
320 5VC5 96M 5.19031
321 6FA4 D1W 5.20231
322 5FQK 6NT 5.20446
323 1Z0N BCD 5.20833
324 5NKB 8ZT 5.22876
325 2IF8 ADP 5.23416
326 5H2U 1N1 5.24345
327 4CYI ATP 5.25114
328 4QTB 38Z 5.26316
329 3SJK LYS PRO VAL LEU ARG THR ALA 5.26316
330 5C03 AGS 5.26316
331 5C4L 4XR 5.29595
332 5C4L SIS 5.29595
333 5O0J GLC 5.29801
334 5IH1 GDP 5.29801
335 5O0J 8BR 5.29801
336 5IH1 6BQ 5.29801
337 6CZ3 FLJ 5.30303
338 2VN9 GVD 5.31561
339 3VPD ANP 5.33808
340 6F5W KG1 5.42005
341 4I94 ANP 5.42553
342 4RF7 ARG 5.43176
343 2PYW ADP 5.47619
344 6EWZ APC 5.48523
345 1T36 ADP 5.49738
346 4F9C 0SX 5.55556
347 1EHI ADP 5.57029
348 5VX9 FUC GAL NAG GAL BGC 5.59006
349 4YMJ 4EJ 5.59211
350 3SXS PP2 5.59701
351 4K55 H6P 5.64516
352 2BPM 529 5.66038
353 5OD2 GLC 5.67686
354 4WOV 3SM 5.67823
355 4AT3 LTI 5.68562
356 4XH0 ADP 5.7072
357 4BCQ TJF 5.72519
358 4BCN T9N 5.72519
359 4BCM T7Z 5.72519
360 4OCJ NDG 5.80475
361 5LMK 6ZK 5.81395
362 5ZTN CUR 5.82751
363 1C1L GAL BGC 5.83942
364 4E1Z 0MX 5.84192
365 4Y24 TD2 5.84416
366 3NW7 LGV 5.86319
367 6GZD LCI 5.88235
368 5FBN 5WF 5.90406
369 3JU6 ANP 5.94595
370 5IGI ZIT 5.98007
371 5IGI GMP 5.98007
372 1K3A ACP 6.02007
373 4Y85 499 6.0241
374 3O0G 3O0 6.04027
375 3TII ANP 6.05263
376 2VZ6 FEF 6.07029
377 3GC0 AMP 6.07903
378 6CDO ALA VAL GLY ILE GLY ALA VAL PHE 6.08696
379 5TT6 ATP 6.09137
380 5VCV 1N1 6.10932
381 1I7L ATP 6.14887
382 1XI9 PLP 6.15764
383 4EWH T77 6.18182
384 3IDB ANP 6.21118
385 6BXI ANP 6.30631
386 2YAK OSV 6.31579
387 1J3R 6PG 6.31579
388 2VDF OCT 6.32411
389 4OCV ANP 6.33245
390 5ODT ADP 6.36042
391 5F6U 5VK 6.36943
392 4Y8D 49J 6.42857
393 3UIM ANP 6.44172
394 4PZ6 GMP 6.45161
395 4IDT T28 6.46067
396 3KN5 ANP 6.46154
397 5MRH Q9Z 6.46552
398 4USI AKG 6.49351
399 4IZY 1J2 6.50407
400 2BKK ADP 6.50888
401 1U59 STU 6.62021
402 3KP6 SAL 6.62252
403 4H3P ANP 6.62983
404 4H3Q ANP 6.62983
405 5EW9 5VC 6.64207
406 5BVE 4VG 6.6482
407 4YZC STU 6.66667
408 3OYW TDG 6.71642
409 4CLI 5P8 6.72783
410 3WG3 A2G GAL NAG FUC 6.74157
411 4YEF 4CQ 6.74157
412 2P7Q GG6 6.76692
413 3EXS 5RP 6.78733
414 4AZW ATP 6.79405
415 4ITH RCM 6.80272
416 3E5A VX6 6.81818
417 1S68 AMP 6.82731
418 5OES ADP 6.8323
419 3VV1 GAL FUC 6.875
420 4EE7 PIS 6.90789
421 5N0L ILE 6.91824
422 2QL9 CIT 6.93642
423 5VNF VAL THR SER VAL VAL 7.00637
424 5WNL STU 7.01754
425 3PLS ANP 7.04698
426 3HZT J60 7.06638
427 3RWP ABQ 7.07396
428 5LVP ATP 7.07396
429 1CM8 ANP 7.08447
430 5FS0 5JC 7.109
431 2RIO ADP 7.14286
432 6FOF LAT 7.14286
433 4A4X JUP 7.16846
434 4JH6 FCN 7.24638
435 1JGU HBC 7.27273
436 4J8T DOG 7.29927
437 3M2W L8I 7.35786
438 2F2U M77 7.46269
439 5HCY 60D 7.55287
440 5BVB DOG 7.57576
441 2ZFZ ARG 7.59494
442 4MA6 28E 7.64331
443 4YMU ARG 7.72727
444 2WQN ADP 7.74194
445 4QCK ASD 7.77202
446 5A6N U7E 7.77385
447 2XG5 EC5 7.79817
448 2XG5 EC2 7.79817
449 5TO8 7FM 7.80142
450 5LXM ADP 7.89474
451 3VRY B43 7.92952
452 3A76 SPD 7.95455
453 1M3U KPL 7.95455
454 4DBH OXL 7.98611
455 5C1M OLC 8
456 3G5D 1N1 8.04196
457 4Q5H ANP 8.04598
458 4TWP AXI 8.11808
459 5YK1 ANP 8.18584
460 1A78 TDG 8.20895
461 1IA9 ANP 8.21429
462 4XV1 904 8.21918
463 1NU4 MLA 8.24742
464 3SRV S19 8.30325
465 2WQ4 SFU 8.33333
466 5YW5 ADE 8.37989
467 6C7Y ADP 8.39161
468 5I35 ANP 8.39695
469 4R78 AMP 8.41424
470 4F4P 0SB 8.42491
471 4OAV ACP 8.61702
472 4CQE CQE 8.63309
473 5EFQ ADP 8.64553
474 1MID LAP 8.79121
475 3IGO ANP 8.84774
476 5H9P TD2 8.86076
477 2G30 ALA ALA PHE 8.91473
478 2R5V HHH 8.96359
479 4M7T SAM 9.25926
480 1XJD STU 9.27536
481 3GQI ACP 9.29204
482 3KMW ATP 9.30233
483 3A6T 8OG 9.30233
484 1DTL BEP 9.31677
485 4MGA 27L 9.41177
486 4I6H 1C8 9.41558
487 4ZS4 ATP 9.44625
488 4IJP 1EH 9.49721
489 1JBU BEN 9.52381
490 1OUK 084 9.56284
491 1TQP ATP 9.57447
492 4LOO SB4 9.69529
493 3THR C2F 9.89761
494 3C1X CKK 9.91957
495 2Z7R STU 9.96885
496 4YEE 4CQ 10
497 3BP1 GUN 10
498 3H9R TAK 10.0917
499 5ODY 9SK 10.1449
500 5GLT BGC GAL NAG GAL 10.2113
501 1AV5 AP2 10.3175
502 4QM9 CYS 10.4046
503 3ESS 18N 10.4348
504 3PDT ADP 10.5455
505 1RV1 IMZ 10.5882
506 4RJD TFP 10.6061
507 3VPB ADP 10.7143
508 2F57 23D 10.7256
509 1GSA ADP 10.7595
510 5L9G MO0 10.8262
511 5W4W 9WG 10.8761
512 4KBA 1QM 10.8761
513 5KHD C2E 10.989
514 1BYG STU 11.1511
515 5Y86 HRM 11.3946
516 2A19 ANP 11.4286
517 5EOB 5QQ 11.5987
518 6CZI 38E 11.6071
519 5KEW 6SB 11.7021
520 5TPV TYD 11.7647
521 2W3L DRO 11.8056
522 2HK5 1BM 11.8519
523 4UXL 5P8 12.7329
524 5L8L ADP 12.8205
525 6GU6 1QK 13.0952
526 5WO4 B7V 13.9073
527 3K5I ADP 14.1439
528 5Y80 IRE 14.1892
529 5HQ0 LZ9 14.2857
530 1TZD ADP 14.5455
531 4G17 0VN 14.5455
532 5KK4 44E 14.5833
533 4M1U A2G MBG 14.8148
534 2WEI VGG 14.9826
535 5K2M ADP 15.0183
536 1YRO UDP 15.4472
537 1PDZ PGA 16.3594
538 5JDA AMP 16.9916
539 4CQK PIO 17.0213
540 1W2D ADP 17.3585
541 3T4L ZEA 17.4074
542 5G1X ADP 17.4603
543 3LQV ADE 17.9487
544 3SAO DBH 18.125
545 5TVI MYR 18.4783
546 2ZV2 609 19.4631
547 4AU8 Z3R 19.9324
548 2GC0 PAN 20.2128
549 1UO5 PIH 20.5882
550 2GU8 796 25
551 4WB6 ATP 25
552 4WB7 ATP 25
553 1KJ1 MAN 27.5229
554 5LXT ACP 28.6713
555 3KO0 TFP 29.703
556 5EYK 5U5 30.5085
557 5UPK ANP 31.25
558 4UWH JXM 34.609
559 4C2W ANP 34.6154
560 4C2V YJA 36.3636
561 1IR3 ANP 38.8889
562 5ZCO CHD 42.2018
563 2PVF ACP 46.6667
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