Receptor
PDB id Resolution Class Description Source Keywords
5AOM 1.74 Å NON-ENZYME: BINDING STRUCTURE OF THE P53 CANCER MUTANT Y220C WITH BOUND SMALL MO PHIKAN883 HOMO SAPIENS CELL CYCLE P53 CANCER TUMOR SUPPRESSION DNA BINDING CANTHERAPY SMALL-MOLECULE STABILIZERS MOLECULAR CHAPERONE
Ref.: EXPLOITING TRANSIENT PROTEIN STATES FOR THE DESIGN SMALL-MOLECULE STABILIZERS OF MUTANT P53. STRUCTURE V. 23 2246 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ZN A:1300;
B:1300;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
65.409 Zn [Zn+2...
FY8 B:1290;
A:1292;
A:1291;
B:1291;
 Valid;
Valid;
Valid;
Valid;
 none;
Atoms found LESS than expected: % Diff = 0.294;
none;
Atoms found LESS than expected: % Diff = 0.294;
 Kd = 1270 uM
254.713 C12 H15 Cl N2 O2 c1cc(...
GOL A:1293;
 Invalid;
 none;
 submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6SI3 1.4 Å NON-ENZYME: BINDING P53 CANCER MUTANT Y220S IN COMPLEX WITH SMALL-MOLECULE STABI PK9301 HOMO SAPIENS P53 TRANSCRIPTION FACTOR TUMOR SUPPRESSOR CANCER THERAPYONCOGENIC MUTANT PROTEIN MISFOLDING DNA-BINDING DOMAIN DSURFACE CREVICE SMALL-MOLECULE STABILIZER MUTANT P53 RESCBINDING PROTEIN
Ref.: TARGETING CAVITY-CREATING P53 CANCER MUTATIONS WITH SMALL-MOLECULE STABILIZERS: THE Y220X PARADIGM. ACS CHEM.BIOL. V. 15 657 2020
Members (40)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 552 families.
1 2X0W - X0W C10 H11 N O2 S Cc1nc2cc(c....
2 4AGM Kd = 105 uM P86 C16 H24 I2 N2 O CCN(CC)C1C....
3 5AB9 Kd = 470 uM 92O C15 H20 N2 CCc1cccc2c....
4 6GGE - EYE C21 H23 N2 S CCn1c2ccc(....
5 2X0V - X0V C7 H7 F3 N2 c1cc(c(cc1....
6 5O1A Kd = 30 uM 9H5 C16 H17 I2 N3 O2 CN1CCN(CC1....
7 5G4O Kd = 37.2 uM O80 C17 H17 F3 N2 CN(C)Cc1cc....
8 5O1F Kd = 30 uM 9GQ C15 H16 I N O4 CCCCOc1cc(....
9 5AOJ Kd = 21 uM Y0V C11 H7 I2 N O3 c1ccn(c1)c....
10 6GGF - EXQ C21 H23 N2 S CCn1c2ccc(....
11 5O1G Kd = 116 uM 9GK C19 H16 I N O4 c1ccc(cc1)....
12 5O1I Kd = 4 uM 9GH C16 H16 I N3 O3 S CCN(CC)c1n....
13 5AOL Kd = 4800 uM UFV C7 H6 Br F3 N2 c1c(cc(c(c....
14 6GGC - EXN C20 H21 N2 O CCn1c2ccc(....
15 5AOI Kd = 940 uM RZH C13 H17 Br N2 CCc1cc(cc2....
16 5O1D Kd = 22 uM 9GW C14 H14 I N O4 CCCOc1cc(c....
17 4AGP Kd = 20.6 uM P51 C25 H31 I N2 O2 CCN(CC)C1C....
18 6SI4 Kd = 5.9 uM LEK C19 H19 N3 S CCn1c2ccc(....
19 3ZME - QC5 C17 H19 F N4 CN(C)CCn1c....
20 5AOK - GOH C11 H10 N6 O c1ccn(c1)c....
21 6SI3 Kd = 4 uM LEB C16 H14 Br F3 N2 CNCc1ccc2c....
22 5A7B Kd = 271 uM KMN C27 H32 N2 O2 CCN(CC)C1C....
23 5ABA Kd = 1040 uM UL7 C17 H24 Br Cl N2 O2 c1c(cc(c(c....
24 6GGD - EYB C19 H20 N3 O CCn1c2ccc(....
25 2VUK Kd = 125 uM P83 C16 H18 N2 CCn1c2cccc....
26 4AGQ Kd = 9.7 uM P96 C25 H32 I N3 O CCN(CC)C1C....
27 5O1E Kd = 33 uM 9GT C14 H12 I N O4 C=CCOc1cc(....
28 4AGN Kd = 107 uM NXG C19 H27 I N2 O2 CCN(CC)C1C....
29 6GGA - EY2 C16 H18 Br N2 CCn1c2ccc(....
30 5O1B Kd = 20 uM 9H2 C11 H9 I2 N O2 c1ccn(c1)c....
31 5AOM Kd = 1270 uM FY8 C12 H15 Cl N2 O2 c1cc(c(cc1....
32 2X0U - X0U C9 H8 N2 O2 S c1c2c(cc3c....
33 4AGO Kd = 15.5 uM P74 C24 H36 I N3 O3 CCN(CC)C1C....
34 5O1C Kd = 113 uM 9GZ C17 H11 F I N O3 c1ccn(c1)c....
35 5G4N Kd = 101 uM O83 C16 H16 F2 N2 CNCc1ccc2c....
36 6GGB - EXQ C21 H23 N2 S CCn1c2ccc(....
37 5O1H Kd = 14 uM 9GN C14 H14 I N O3 S CCCSc1cc(c....
38 4AGL Kd = 225 uM P84 C14 H20 I2 N2 O CN1CCC(CC1....
39 6SI0 Kd = 5.3 uM LEK C19 H19 N3 S CCn1c2ccc(....
40 5G4M Kd = 138 uM O82 C16 H17 F N2 CNCc1ccc2c....
70% Homology Family (40)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 426 families.
1 2X0W - X0W C10 H11 N O2 S Cc1nc2cc(c....
2 4AGM Kd = 105 uM P86 C16 H24 I2 N2 O CCN(CC)C1C....
3 5AB9 Kd = 470 uM 92O C15 H20 N2 CCc1cccc2c....
4 6GGE - EYE C21 H23 N2 S CCn1c2ccc(....
5 2X0V - X0V C7 H7 F3 N2 c1cc(c(cc1....
6 5O1A Kd = 30 uM 9H5 C16 H17 I2 N3 O2 CN1CCN(CC1....
7 5G4O Kd = 37.2 uM O80 C17 H17 F3 N2 CN(C)Cc1cc....
8 5O1F Kd = 30 uM 9GQ C15 H16 I N O4 CCCCOc1cc(....
9 5AOJ Kd = 21 uM Y0V C11 H7 I2 N O3 c1ccn(c1)c....
10 6GGF - EXQ C21 H23 N2 S CCn1c2ccc(....
11 5O1G Kd = 116 uM 9GK C19 H16 I N O4 c1ccc(cc1)....
12 5O1I Kd = 4 uM 9GH C16 H16 I N3 O3 S CCN(CC)c1n....
13 5AOL Kd = 4800 uM UFV C7 H6 Br F3 N2 c1c(cc(c(c....
14 6GGC - EXN C20 H21 N2 O CCn1c2ccc(....
15 5AOI Kd = 940 uM RZH C13 H17 Br N2 CCc1cc(cc2....
16 5O1D Kd = 22 uM 9GW C14 H14 I N O4 CCCOc1cc(c....
17 4AGP Kd = 20.6 uM P51 C25 H31 I N2 O2 CCN(CC)C1C....
18 6SI4 Kd = 5.9 uM LEK C19 H19 N3 S CCn1c2ccc(....
19 3ZME - QC5 C17 H19 F N4 CN(C)CCn1c....
20 5AOK - GOH C11 H10 N6 O c1ccn(c1)c....
21 6SI3 Kd = 4 uM LEB C16 H14 Br F3 N2 CNCc1ccc2c....
22 5A7B Kd = 271 uM KMN C27 H32 N2 O2 CCN(CC)C1C....
23 5ABA Kd = 1040 uM UL7 C17 H24 Br Cl N2 O2 c1c(cc(c(c....
24 6GGD - EYB C19 H20 N3 O CCn1c2ccc(....
25 2VUK Kd = 125 uM P83 C16 H18 N2 CCn1c2cccc....
26 4AGQ Kd = 9.7 uM P96 C25 H32 I N3 O CCN(CC)C1C....
27 5O1E Kd = 33 uM 9GT C14 H12 I N O4 C=CCOc1cc(....
28 4AGN Kd = 107 uM NXG C19 H27 I N2 O2 CCN(CC)C1C....
29 6GGA - EY2 C16 H18 Br N2 CCn1c2ccc(....
30 5O1B Kd = 20 uM 9H2 C11 H9 I2 N O2 c1ccn(c1)c....
31 5AOM Kd = 1270 uM FY8 C12 H15 Cl N2 O2 c1cc(c(cc1....
32 2X0U - X0U C9 H8 N2 O2 S c1c2c(cc3c....
33 4AGO Kd = 15.5 uM P74 C24 H36 I N3 O3 CCN(CC)C1C....
34 5O1C Kd = 113 uM 9GZ C17 H11 F I N O3 c1ccn(c1)c....
35 5G4N Kd = 101 uM O83 C16 H16 F2 N2 CNCc1ccc2c....
36 6GGB - EXQ C21 H23 N2 S CCn1c2ccc(....
37 5O1H Kd = 14 uM 9GN C14 H14 I N O3 S CCCSc1cc(c....
38 4AGL Kd = 225 uM P84 C14 H20 I2 N2 O CN1CCC(CC1....
39 6SI0 Kd = 5.3 uM LEK C19 H19 N3 S CCn1c2ccc(....
40 5G4M Kd = 138 uM O82 C16 H17 F N2 CNCc1ccc2c....
50% Homology Family (40)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 322 families.
1 2X0W - X0W C10 H11 N O2 S Cc1nc2cc(c....
2 4AGM Kd = 105 uM P86 C16 H24 I2 N2 O CCN(CC)C1C....
3 5AB9 Kd = 470 uM 92O C15 H20 N2 CCc1cccc2c....
4 6GGE - EYE C21 H23 N2 S CCn1c2ccc(....
5 2X0V - X0V C7 H7 F3 N2 c1cc(c(cc1....
6 5O1A Kd = 30 uM 9H5 C16 H17 I2 N3 O2 CN1CCN(CC1....
7 5G4O Kd = 37.2 uM O80 C17 H17 F3 N2 CN(C)Cc1cc....
8 5O1F Kd = 30 uM 9GQ C15 H16 I N O4 CCCCOc1cc(....
9 5AOJ Kd = 21 uM Y0V C11 H7 I2 N O3 c1ccn(c1)c....
10 6GGF - EXQ C21 H23 N2 S CCn1c2ccc(....
11 5O1G Kd = 116 uM 9GK C19 H16 I N O4 c1ccc(cc1)....
12 5O1I Kd = 4 uM 9GH C16 H16 I N3 O3 S CCN(CC)c1n....
13 5AOL Kd = 4800 uM UFV C7 H6 Br F3 N2 c1c(cc(c(c....
14 6GGC - EXN C20 H21 N2 O CCn1c2ccc(....
15 5AOI Kd = 940 uM RZH C13 H17 Br N2 CCc1cc(cc2....
16 5O1D Kd = 22 uM 9GW C14 H14 I N O4 CCCOc1cc(c....
17 4AGP Kd = 20.6 uM P51 C25 H31 I N2 O2 CCN(CC)C1C....
18 6SI4 Kd = 5.9 uM LEK C19 H19 N3 S CCn1c2ccc(....
19 3ZME - QC5 C17 H19 F N4 CN(C)CCn1c....
20 5AOK - GOH C11 H10 N6 O c1ccn(c1)c....
21 6SI3 Kd = 4 uM LEB C16 H14 Br F3 N2 CNCc1ccc2c....
22 5A7B Kd = 271 uM KMN C27 H32 N2 O2 CCN(CC)C1C....
23 5ABA Kd = 1040 uM UL7 C17 H24 Br Cl N2 O2 c1c(cc(c(c....
24 6GGD - EYB C19 H20 N3 O CCn1c2ccc(....
25 2VUK Kd = 125 uM P83 C16 H18 N2 CCn1c2cccc....
26 4AGQ Kd = 9.7 uM P96 C25 H32 I N3 O CCN(CC)C1C....
27 5O1E Kd = 33 uM 9GT C14 H12 I N O4 C=CCOc1cc(....
28 4AGN Kd = 107 uM NXG C19 H27 I N2 O2 CCN(CC)C1C....
29 6GGA - EY2 C16 H18 Br N2 CCn1c2ccc(....
30 5O1B Kd = 20 uM 9H2 C11 H9 I2 N O2 c1ccn(c1)c....
31 5AOM Kd = 1270 uM FY8 C12 H15 Cl N2 O2 c1cc(c(cc1....
32 2X0U - X0U C9 H8 N2 O2 S c1c2c(cc3c....
33 4AGO Kd = 15.5 uM P74 C24 H36 I N3 O3 CCN(CC)C1C....
34 5O1C Kd = 113 uM 9GZ C17 H11 F I N O3 c1ccn(c1)c....
35 5G4N Kd = 101 uM O83 C16 H16 F2 N2 CNCc1ccc2c....
36 6GGB - EXQ C21 H23 N2 S CCn1c2ccc(....
37 5O1H Kd = 14 uM 9GN C14 H14 I N O3 S CCCSc1cc(c....
38 4AGL Kd = 225 uM P84 C14 H20 I2 N2 O CN1CCC(CC1....
39 6SI0 Kd = 5.3 uM LEK C19 H19 N3 S CCn1c2ccc(....
40 5G4M Kd = 138 uM O82 C16 H17 F N2 CNCc1ccc2c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: FY8; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 FY8 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: FY8; Similar ligands found: 495
No: Ligand Similarity coefficient
1 0OP 0.9477
2 3IP 0.9475
3 DDC 0.9419
4 NW1 0.9410
5 3D8 0.9377
6 G30 0.9374
7 AOY 0.9358
8 C4E 0.9347
9 RE4 0.9311
10 FCW 0.9296
11 FHV 0.9291
12 0QV 0.9290
13 0UL 0.9290
14 5E5 0.9286
15 57D 0.9276
16 EMU 0.9276
17 7EH 0.9270
18 848 0.9269
19 38E 0.9263
20 833 0.9260
21 0X2 0.9257
22 0DF 0.9256
23 8CC 0.9247
24 ZRK 0.9242
25 0ON 0.9241
26 0SY 0.9239
27 ZRL 0.9236
28 68B 0.9235
29 0OK 0.9232
30 MJW 0.9227
31 2JX 0.9207
32 DFV 0.9198
33 47V 0.9197
34 7L4 0.9196
35 4ZF 0.9195
36 3WL 0.9195
37 NAR 0.9193
38 6C9 0.9192
39 CMG 0.9189
40 5ER 0.9186
41 YIP 0.9182
42 NAL 0.9182
43 DFL 0.9172
44 LR2 0.9170
45 3F4 0.9166
46 CUH 0.9161
47 F40 0.9156
48 CWE 0.9155
49 83D 0.9154
50 LJ5 0.9153
51 7LU 0.9151
52 0FR 0.9150
53 3JC 0.9150
54 RSV 0.9148
55 WA2 0.9148
56 FYR 0.9147
57 4CN 0.9146
58 AJ4 0.9144
59 11X 0.9142
60 LJ4 0.9142
61 6J5 0.9135
62 1Q4 0.9132
63 CBE 0.9131
64 L2K 0.9131
65 X2M 0.9129
66 SZ5 0.9125
67 5VU 0.9123
68 F18 0.9122
69 6H2 0.9116
70 8M5 0.9112
71 IEE 0.9110
72 GJG 0.9110
73 QME 0.9109
74 6DQ 0.9100
75 AGI 0.9100
76 LU2 0.9099
77 20D 0.9097
78 JPQ 0.9095
79 A51 0.9090
80 TPM 0.9083
81 LJ1 0.9080
82 9JT 0.9078
83 LJ2 0.9076
84 UN4 0.9070
85 0OO 0.9069
86 25F 0.9067
87 WLH 0.9066
88 2QU 0.9063
89 4YF 0.9059
90 H35 0.9057
91 5TO 0.9057
92 LI7 0.9055
93 M77 0.9052
94 A73 0.9050
95 XIF XYP 0.9049
96 1V1 0.9049
97 HBI 0.9049
98 P2L 0.9046
99 UV4 0.9044
100 D9Z 0.9043
101 U13 0.9043
102 4GU 0.9038
103 NKI 0.9036
104 EV2 0.9034
105 DZ1 0.9032
106 TRP 0.9032
107 YE6 0.9028
108 AUY 0.9028
109 MBP 0.9028
110 O9T 0.9026
111 RGK 0.9025
112 4YE 0.9021
113 1XS 0.9019
114 S7D 0.9016
115 XYP XDN 0.9016
116 6QT 0.9014
117 RE2 0.9014
118 STL 0.9014
119 OLU 0.9013
120 P4T 0.9013
121 KWB 0.9012
122 AVX 0.9012
123 531 0.9010
124 8KW 0.9010
125 QC1 0.9009
126 92O 0.9008
127 LZ7 0.9008
128 S0D 0.9007
129 AP6 0.9006
130 BVB 0.9005
131 MHB 0.9004
132 VJJ 0.9003
133 XIL 0.9003
134 2M7 0.9001
135 7FZ 0.8999
136 B5A 0.8998
137 RK4 0.8997
138 KMP 0.8996
139 XYP XYP 0.8996
140 2P3 0.8993
141 C1E 0.8992
142 6BK 0.8990
143 NIY 0.8990
144 2L2 0.8988
145 WCU 0.8987
146 OA4 0.8985
147 Q9T 0.8984
148 4K2 0.8980
149 D64 0.8979
150 AX5 0.8978
151 E6Q 0.8976
152 Q5M 0.8976
153 2OX 0.8975
154 4L2 0.8972
155 5S9 0.8972
156 IDD 0.8971
157 JF5 0.8971
158 2L1 0.8966
159 2D2 0.8965
160 S7V 0.8964
161 397 0.8963
162 JVD 0.8963
163 ZIP 0.8962
164 9CE 0.8959
165 GJB 0.8959
166 P4L 0.8958
167 LZ5 0.8953
168 3Q0 0.8952
169 XYP XYS 0.8950
170 ZEZ 0.8949
171 XYS XYS 0.8946
172 1V8 0.8946
173 XDL XYP 0.8946
174 GOW 0.8946
175 XYP XIF 0.8945
176 OUA 0.8943
177 T61 0.8934
178 SAK 0.8932
179 6WR 0.8931
180 H75 0.8930
181 SCE 0.8929
182 120 0.8929
183 KLV 0.8929
184 DX2 0.8927
185 5WK 0.8927
186 H4B 0.8925
187 15Q 0.8925
188 3WK 0.8924
189 536 0.8922
190 124 0.8922
191 6P3 0.8920
192 TJM 0.8920
193 L3L 0.8919
194 3GX 0.8918
195 NEU 0.8917
196 3TI 0.8917
197 DXK 0.8916
198 NU3 0.8915
199 LVY 0.8915
200 QS4 0.8915
201 XYS XYP 0.8913
202 EAT 0.8912
203 8BD 0.8911
204 ZEA 0.8910
205 FER 0.8909
206 6XC 0.8905
207 GQE 0.8899
208 D25 0.8899
209 YE7 0.8899
210 G14 0.8898
211 M3W 0.8896
212 VT3 0.8894
213 IW4 0.8893
214 28A 0.8892
215 SJR 0.8891
216 1ZC 0.8889
217 AJ6 0.8889
218 MPU 0.8888
219 4AF 0.8887
220 22T 0.8886
221 A5Q 0.8884
222 NPS 0.8883
223 DZ2 0.8882
224 A4V 0.8880
225 BMC 0.8880
226 D8B 0.8879
227 5NN 0.8879
228 2GQ 0.8878
229 Q2S 0.8877
230 XCG 0.8876
231 J38 0.8876
232 E9L 0.8873
233 LI4 0.8873
234 SQM 0.8871
235 26C 0.8869
236 G6P 0.8868
237 0LA 0.8867
238 3AK 0.8867
239 HHV 0.8865
240 0NJ 0.8864
241 1V4 0.8862
242 RDM 0.8861
243 KLS 0.8860
244 NYJ 0.8859
245 XDN XYP 0.8856
246 TMG 0.8856
247 27F 0.8855
248 C4F 0.8853
249 4FF 0.8852
250 7AP 0.8851
251 ZTW 0.8851
252 BSU 0.8851
253 5OR 0.8850
254 7G0 0.8850
255 97K 0.8848
256 108 0.8846
257 BIO 0.8845
258 08C 0.8844
259 6ZW 0.8843
260 DQH 0.8840
261 5BX 0.8838
262 5WN 0.8834
263 EF2 0.8831
264 CDJ 0.8830
265 ADN 0.8829
266 NIF 0.8828
267 I2E 0.8827
268 IW3 0.8826
269 PTB 0.8824
270 78P 0.8823
271 N5B 0.8823
272 W8L 0.8822
273 IDZ 0.8822
274 5F1 0.8822
275 121 0.8821
276 0H5 0.8820
277 5DE 0.8820
278 H2W 0.8820
279 IW5 0.8819
280 BMZ 0.8817
281 A18 0.8817
282 3D3 0.8814
283 JCZ 0.8813
284 B4L 0.8813
285 3DE 0.8812
286 OJD 0.8810
287 BVS 0.8808
288 3XH 0.8808
289 4TX 0.8808
290 WG8 0.8807
291 PQS 0.8803
292 S0A 0.8802
293 GOE 0.8801
294 122 0.8801
295 KYN 0.8799
296 8CV 0.8797
297 P1J 0.8796
298 G2V 0.8795
299 KWV 0.8795
300 8OB 0.8795
301 5C1 0.8794
302 4BX 0.8792
303 ZSP 0.8792
304 E9S 0.8792
305 5CK 0.8792
306 NEO 0.8791
307 3D1 0.8791
308 GA2 0.8790
309 5AD 0.8790
310 5TU 0.8787
311 MUX 0.8787
312 TCW 0.8786
313 697 0.8786
314 NZ4 0.8786
315 NQ7 0.8786
316 1Q1 0.8784
317 DBS 0.8783
318 KXN 0.8783
319 AUG 0.8783
320 6C4 0.8782
321 6L6 0.8781
322 0XR 0.8779
323 IW1 0.8779
324 AUE 0.8778
325 3CA 0.8777
326 JNW 0.8776
327 AHR AHR 0.8775
328 91F 0.8770
329 HWB 0.8770
330 72E 0.8768
331 5FD 0.8768
332 1FL 0.8767
333 56N 0.8766
334 SIJ 0.8765
335 HWH 0.8764
336 IW2 0.8763
337 H2B 0.8763
338 52F 0.8763
339 CDX 0.8762
340 O9Q 0.8760
341 ERZ 0.8755
342 U14 0.8755
343 HO6 0.8754
344 A63 0.8754
345 HFS 0.8752
346 TH1 0.8751
347 HA6 0.8750
348 1A5 0.8749
349 BX4 0.8749
350 EES 0.8748
351 3WJ 0.8747
352 NXB 0.8745
353 4Z0 0.8743
354 CJZ 0.8743
355 GEN 0.8742
356 IMK 0.8741
357 CTE 0.8740
358 6TJ 0.8739
359 O9Z 0.8738
360 XYS AZI XYS 0.8736
361 M5A 0.8736
362 NOC 0.8736
363 NK5 0.8734
364 6NZ 0.8734
365 CC5 0.8727
366 BTN 0.8727
367 LIG 0.8727
368 FF2 0.8726
369 EDG AHR 0.8726
370 D26 0.8726
371 MXD 0.8725
372 7ZO 0.8725
373 4AB 0.8723
374 3G1 0.8721
375 PUR 0.8721
376 7PJ 0.8721
377 6WU 0.8717
378 4F8 0.8716
379 IXG 0.8714
380 BHS 0.8713
381 IMH 0.8713
382 CL9 0.8712
383 15I 0.8709
384 S8G 0.8708
385 72G 0.8705
386 DH2 0.8701
387 4G2 0.8701
388 SNV 0.8698
389 3VQ 0.8695
390 LRT 0.8694
391 ZAR 0.8694
392 EEK 0.8689
393 Y70 0.8689
394 EEY 0.8687
395 XRS 0.8686
396 X2L 0.8685
397 SB9 0.8680
398 TGW 0.8680
399 MZR 0.8680
400 1AJ 0.8680
401 ZYC 0.8680
402 AD3 0.8678
403 5WT 0.8678
404 M83 0.8676
405 50Q 0.8674
406 LVE 0.8674
407 ARJ 0.8673
408 M01 0.8672
409 1DA 0.8672
410 NPX 0.8670
411 802 0.8667
412 GNW 0.8667
413 GNG 0.8663
414 IQP 0.8663
415 Y0V 0.8661
416 4P9 0.8661
417 NPZ 0.8660
418 DMB 0.8657
419 5CJ 0.8656
420 23M 0.8655
421 T1N 0.8655
422 5M2 0.8653
423 NFZ 0.8653
424 27K 0.8653
425 B2L 0.8652
426 HPR 0.8649
427 6SZ 0.8647
428 2LT 0.8647
429 35G 0.8647
430 DHC 0.8645
431 TYP 0.8640
432 SXX 0.8638
433 CDY 0.8638
434 2J1 0.8637
435 GZV 0.8637
436 0QA 0.8636
437 EI1 0.8636
438 KVD 0.8635
439 PRH 0.8635
440 MQS 0.8633
441 5P7 0.8631
442 D5F 0.8631
443 GMP 0.8630
444 LOT 0.8629
445 6T5 0.8629
446 H52 0.8627
447 A6W 0.8627
448 MI2 0.8625
449 A5K 0.8625
450 BG6 0.8619
451 D1G 0.8612
452 HFT 0.8612
453 1KN 0.8611
454 6JP 0.8610
455 14W 0.8605
456 SX2 0.8604
457 FC2 0.8603
458 6SX 0.8602
459 7ZL 0.8602
460 KF5 0.8601
461 NX5 0.8601
462 TB8 0.8596
463 5E4 0.8596
464 ASE 0.8593
465 5WS 0.8593
466 NX1 0.8591
467 LZJ 0.8590
468 SOJ 0.8589
469 RFZ 0.8588
470 JO5 0.8587
471 ESE 0.8586
472 1HR 0.8585
473 5F7 0.8583
474 Q11 0.8582
475 CIU 0.8581
476 NE1 0.8576
477 22M 0.8575
478 T5J 0.8573
479 GVI 0.8571
480 M08 0.8564
481 3N0 0.8563
482 H32 0.8562
483 HPZ 0.8558
484 5XK 0.8557
485 N9M 0.8556
486 3CX 0.8555
487 TBN 0.8554
488 GF7 0.8551
489 VC3 0.8547
490 4R1 0.8545
491 MMS 0.8544
492 BXS 0.8537
493 PCG 0.8535
494 NXY 0.8531
495 A6Z 0.8528
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6SI3; Ligand: LEB; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6si3.bio2) has 21 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 6SI3; Ligand: LEB; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 6si3.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
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