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Receptor
PDB id Resolution Class Description Source Keywords
5C5T 1.6 Å EC: 3.-.-.- THE CRYSTAL STRUCTURE OF VIRAL COLLAGEN PROLYL HYDROXYLASE V PARAMECIUM BURSARIA CHLORELLA VIRUS-1 - 2OG COMPLEX PARAMECIUM BURSARIA CHLORELLA VIRUS 1 DIOXYGENASE PROLYL HYDROXYLASE OXIDOREDUCTASE
Ref.: STRUCTURE AND MECHANISM OF A VIRAL COLLAGEN PROLYL HYDROXYLASE. BIOCHEMISTRY V. 54 6093 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AKG B:301;
A:301;
Valid;
Valid;
none;
none;
Kd = 681 uM
146.098 C5 H6 O5 C(CC(...
ZN A:302;
B:302;
Part of Protein;
Part of Protein;
none;
none;
submit data
65.409 Zn [Zn+2...
MN A:303;
Part of Protein;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5C5T 1.6 Å EC: 3.-.-.- THE CRYSTAL STRUCTURE OF VIRAL COLLAGEN PROLYL HYDROXYLASE V PARAMECIUM BURSARIA CHLORELLA VIRUS-1 - 2OG COMPLEX PARAMECIUM BURSARIA CHLORELLA VIRUS 1 DIOXYGENASE PROLYL HYDROXYLASE OXIDOREDUCTASE
Ref.: STRUCTURE AND MECHANISM OF A VIRAL COLLAGEN PROLYL HYDROXYLASE. BIOCHEMISTRY V. 54 6093 2015
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 253 families.
1 5C5T Kd = 681 uM AKG C5 H6 O5 C(CC(=O)O)....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 5C5T Kd = 681 uM AKG C5 H6 O5 C(CC(=O)O)....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 173 families.
1 5C5T Kd = 681 uM AKG C5 H6 O5 C(CC(=O)O)....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: AKG; Similar ligands found: 7
No: Ligand ECFP6 Tc MDL keys Tc
1 AKG 1 1
2 SIN 0.526316 0.833333
3 OOG 0.5 0.947368
4 69O 0.458333 0.714286
5 2IT 0.423077 0.615385
6 SHF 0.416667 0.666667
7 3PY 0.409091 0.652174
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5C5T; Ligand: AKG; Similar sites found with APoc: 237
This union binding pocket(no: 1) in the query (biounit: 5c5t.bio1) has 15 residues
No: Leader PDB Ligand Sequence Similarity
1 1DZK PRZ None
2 1GQG DCD 1.31579
3 5ML3 DL3 1.34228
4 3FW4 CAQ 1.68539
5 2RDQ AKG 1.75439
6 4YZC STU 1.75439
7 1H5T DAU 1.75439
8 5SVV FMN 2.18978
9 5I0U DCY 2.19298
10 3W68 VIV 2.19298
11 4HIA FMN 2.27273
12 3A6T 8OG 2.32558
13 2AG4 OLA 2.43902
14 2AG4 LP3 2.43902
15 4BXF AKG 2.63158
16 3PUA OGA 2.63158
17 4XAC AKG 2.63158
18 5JSP DQY 2.63158
19 6F6J SIN 2.63158
20 1PVN MZP 2.63158
21 4J7Q B7N 2.63158
22 6F6J CUW 2.63158
23 1IA9 ANP 2.63158
24 2TPS TPS 2.64317
25 4YBN FAD 2.67857
26 4OCT AKG 2.7027
27 4L4J NAG NAG BMA MAN NAG 2.71493
28 5BU3 4W9 2.71739
29 5I8T LAC 2.7933
30 4R38 RBF 2.85714
31 6FXR AKG 3.07018
32 3P3N AKG 3.07018
33 4P7X YCP 3.07018
34 4P7X AKG 3.07018
35 2Y0I AKG 3.07018
36 1H2K OGA 3.07018
37 5JWP AKG 3.07018
38 2XUM OGA 3.07018
39 4B7E OGA 3.07018
40 2OG7 SIN 3.07018
41 3PUR 2HG 3.07018
42 3KV4 OGA 3.07018
43 2XK9 XK9 3.07018
44 2WA4 069 3.07018
45 3KV5 OGA 3.07018
46 4X7Q 3YR 3.07018
47 3N9O OGA 3.07018
48 4BVA T3 3.07018
49 4NW6 2NS 3.40557
50 1TKU 5RP 3.43137
51 1QY1 PRZ 3.44828
52 5IQT AKG 3.49206
53 5IQT 6CU 3.49206
54 3NNF AKG 3.50877
55 2WBP ZZU 3.50877
56 2WBP SIN 3.50877
57 5F3I 5UJ 3.50877
58 5IVE 6E8 3.50877
59 5FWE OGA 3.50877
60 2YBP 2HG 3.50877
61 4ZSI 4R1 3.50877
62 1UNB AKG 3.50877
63 5LY2 OGA 3.50877
64 2OS2 OGA 3.50877
65 1UNB PN1 3.50877
66 6H8P OGA 3.50877
67 5YU3 PRO 3.50877
68 5YU3 NAD 3.50877
69 1B8O IMH 3.50877
70 4MP8 MLI 3.53982
71 4MP8 NAD 3.53982
72 5DYO FLU 3.66972
73 1N9L FMN 3.66972
74 1J3R 6PG 3.68421
75 5T48 MGP 3.80435
76 2IXH TRH 3.80435
77 1GP6 SIN 3.94737
78 1GP6 DH2 3.94737
79 1GP6 QUE 3.94737
80 5XEG AKG 3.94737
81 4NAO AKG 3.94737
82 2A1X AKG 3.94737
83 5UR1 YY9 3.94737
84 5W75 SUC 3.94737
85 3G5D 1N1 3.94737
86 1PIG BGC 3.94737
87 3OPT AKG 3.94737
88 4ZAD 4LU 3.94737
89 4ZXA H8N 3.94737
90 3WW2 SF6 3.94737
91 3H9A PPY 3.94737
92 2IXC TRH 3.94737
93 2CM4 RCL 4
94 4ZU4 4TG 4.05405
95 2QL9 CIT 4.12371
96 5IXG OTP 4.14201
97 1DRY AKG 4.38596
98 1DRY AAG 4.38596
99 2XMY CDK 4.38596
100 6F4T OGA 4.38596
101 2OBD 2OB 4.38596
102 5DEY 59T 4.38596
103 3ZDS M8O 4.38596
104 3ZDS HQ9 4.38596
105 2ET1 GLV 4.47761
106 3T50 FMN 4.6875
107 1NX4 AKG 4.82456
108 5M0T AKG 4.82456
109 6F6D AKG 4.82456
110 5FWJ MMK 4.82456
111 5FP3 3JI 4.82456
112 5UQD AKG 4.82456
113 2F7A BEZ 4.82456
114 5FLJ QUE 4.82456
115 1GT4 UNA 5.03145
116 1OIK C26 5.26316
117 1OIK AKG 5.26316
118 1OIJ AKG 5.26316
119 4QXB OGA 5.26316
120 3GJB AKG 5.26316
121 1QD1 FON 5.26316
122 3B1Q NOS 5.26316
123 5XIJ ANP 5.26316
124 5XIJ 873 5.26316
125 3MTX PGT 5.29801
126 3E2M E2M 5.40541
127 4NPL AKG 5.70175
128 4CCK OGA 5.70175
129 4CCO OGA 5.70175
130 4CCN OGA 5.70175
131 4Y3O OGA 5.70175
132 6FUL E7Z 5.70175
133 2A1L PCW 5.70175
134 3EW2 BTN 5.92593
135 2FCU AKG 6.14035
136 5EPA AKG 6.14035
137 3H7J PPY 6.14035
138 3ACL 3F1 6.14035
139 4ZAC 4LU 6.14035
140 4UEC MGT 6.41026
141 5FP4 YC8 6.57895
142 3W21 AKG 6.57895
143 6EOZ AKG 6.57895
144 6EOZ 58K 6.57895
145 3BW2 FMN 6.57895
146 6C8R EQV 6.57895
147 3TAY MN0 6.74847
148 4IEN GDP 6.74847
149 2GJ5 VD3 6.79012
150 5O9W AKG 7.01754
151 1OS7 TAU 7.01754
152 1OS7 AKG 7.01754
153 5EQU 5R6 7.01754
154 3E9I XAH 7.01754
155 4TVD BGC 7.01754
156 3SCH TB6 7.07071
157 6GNO XDI 7.40741
158 4BG1 OGA 7.45614
159 4BG1 IVL 7.45614
160 4IGQ THR M3L GLN 7.45614
161 2GC0 PAN 7.45614
162 4IGQ OGA 7.45614
163 5KR7 6X9 7.45614
164 3E85 BSU 7.59494
165 1WUB OTP 7.86517
166 5A3T MMK 7.89474
167 5YJS SAL 7.89474
168 4QCK ASD 7.89474
169 3OTX AP5 7.89474
170 6CZI 38E 8.03571
171 3FW9 SLX 8.33333
172 6EXF LYS 8.33333
173 5XIO HFG 8.33333
174 5VAD 91Y 8.33333
175 4QM9 CYS 8.67052
176 1ODM ASV 8.77193
177 4RFR RHN 8.86699
178 5U98 1KX 9.09091
179 3QUZ QUV 9.09091
180 4IE6 UN9 9.21053
181 4OJ8 AKG 9.21053
182 5NCJ SIN 9.21053
183 4OJ8 2TQ 9.21053
184 5NCJ HL5 9.21053
185 2Y6Q I7T 9.21053
186 5YBN AKG 9.21053
187 2G30 ALA ALA PHE 9.21053
188 3FU7 D2M 9.21053
189 4M26 AKG 9.64912
190 4M26 ZZU 9.64912
191 4M26 SIN 9.64912
192 4C3Y ANB 9.64912
193 5H5A 6OU 10
194 5L9V OGA 10.0877
195 5LUN OGA 10.0877
196 5LUN ARG 10.0877
197 6MPT C30 10.5263
198 2Z77 HE7 10.7914
199 5C3R AKG 10.9649
200 5C3R HMU 10.9649
201 2IUW AKG 10.9649
202 4LIT AKG 10.9649
203 3HQR OGA 11.4035
204 5L9B AKG 11.4035
205 5OX6 A1Z 11.4035
206 1X7D ORN 11.4035
207 4JZR 4JR 12.037
208 2ZSC BTN 12.0567
209 4QAC KK3 12.4424
210 5FPX GLY SER SER HIS HIS HIS HIS HIS 13.2743
211 3D72 FAD 13.4228
212 5D48 L96 13.8158
213 5HWV MBN 13.8462
214 5F6U 5VK 14.6497
215 4WN5 MVC 14.7826
216 4NV7 COA 14.9123
217 5EFW FMN 15
218 5V1B 8UY 16.6667
219 3LOO B4P 17.1053
220 2BOS GLA GAL 17.6471
221 3AJH BL3 17.9825
222 4XCB AKG 20.614
223 4XCB HY0 20.614
224 2P5B OGA 22.7273
225 5IXH OTP 24.2236
226 5ZM4 9FU 25
227 5ZM4 AKG 25
228 3N9P OGA 25
229 2Q8E OGA 25
230 5FUI APY 25
231 5YBL AKG 29.386
232 1H2M OGA 36.5385
233 3AVR OGA 40.9091
234 2JIG PD2 42.8571
235 4J25 OGA 43.2314
236 5HV0 AKG 44.7368
237 3N9Q OGA 47.0588
Pocket No.: 2; Query (leader) PDB : 5C5T; Ligand: AKG; Similar sites found with APoc: 23
This union binding pocket(no: 2) in the query (biounit: 5c5t.bio2) has 15 residues
No: Leader PDB Ligand Sequence Similarity
1 6F5W KG1 2.19298
2 2IFW ACE PHE LYS PHE PSA LEU AAR 2.42718
3 4MZU TYD 2.63158
4 5NW7 9C2 3.07018
5 5KD6 LBU 3.07018
6 5KD6 6C7 3.07018
7 3TTI KBI 3.50877
8 6C1S EFV 3.50877
9 2GU8 796 3.94737
10 3NEM AMO 3.94737
11 3FW3 ETS 3.94737
12 1RJW ETF 4.82456
13 2HKA C3S 5.38462
14 5FQK 6NT 5.57621
15 1OX5 1PR 6.14035
16 3M94 M7M 6.14035
17 4YGF AZM 7.01754
18 1IIU RTL 8.62069
19 4RYV ZEA 9.03226
20 2YG2 FLC 9.88372
21 1U0A BGC BGC BGC BGC 11.215
22 5TFZ 7BC 14
23 1LRH NLA 15.9509
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