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Receptor

PDB id	Resolution	Class	Description	Source	Keywords
5C87	1.55 Å	NON-ENZYME: OTHER	CRYSTAL STRUCTURE OF THE HUMAN BRPF1 BROMODOMAIN IN COMPLEX	HOMO SAPIENS	BROMODOMAIN AND PHD FINGER-CONTAINING PROTEIN 1(BRPF1) MONOLEUKEMIA ZINC-FINGER (MOZ) INHIBITOR DNA BINDING PROTEIN
Ref.:	TWENTY CRYSTAL STRUCTURES OF BROMODOMAIN AND PHD FI CONTAINING PROTEIN 1 (BRPF1)/LIGAND COMPLEXES REVEA CONSERVED BINDING MOTIFS AND RARE INTERACTIONS. J.MED.CHEM. V. 59 5555 2016

Ligand

Ligand	Chain:Residue	Validity	Ligand Warnings	Binding Data	NGL Viewer	Molecular Weight (Da)	Formula	SMILES
4YS	A:802;	Valid;	none;	submit data		145.158	C9 H7 N O	c1ccc...
NO3	A:801;	Invalid;	none;	submit data		62.005	N O3	[N+](...

View in 3D viewer

90% Homology Family

Leader

PDB id	Resolution	Class	Description	Source	Keywords
4UYE	1.65 Å	NON-ENZYME: OTHER	BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-DIMETHYL-2-OXO-6-( PIPERIDIN-1-YL)-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-5-YL-2- M ETHOXYBENZAMIDE	HOMO SAPIENS	TRANSCRIPTION INHIBITOR HISTONE EPIGENETIC READER ANTAGO
Ref.:	1,3-DIMETHYL BENZIMIDAZOLONES ARE POTENT, SELECTIVE INHIBITORS OF THE BRPF1 BROMODOMAIN. ACS MED.CHEM.LETT. V. 5 1190 2014

Members (37)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 1610 families.
1	5E3G	-	5JQ	C5 H4 N4 O2 S	C12=C(NC(=....
2	5T4U	ic50 = 4800 nM	12Q	C10 H9 N O	CN1c2ccccc....
3	5EWH	Kd = 170 uM	5SG	C9 H7 N O	c1cc2cnccc....
4	5C85	Kd = 105 uM	4YO	C8 H7 Br N2 O	c1cc2c(cc1....
5	5E3D	Kd = 95 uM	5JL	C5 H4 N4 O S2	C12=C(NC(=....
6	5C87	-	4YS	C9 H7 N O	c1ccc2c(c1....
7	5O4T	-	9KT	C10 H10 N2 O2	CN1c2ccccc....
8	5OV8	Kd = 18 uM	AXN	C24 H30 N4 O4 S	CC(C)Cc1cc....
9	5O4S	ic50 = 3.4 uM	9KW	C24 H28 N4 O5 S	CN1c2cc(c(....
10	5MWH	Kd = 1.8 uM	UWX	C24 H30 N4 O5 S	CC(C)Cc1cc....
11	5DY7	-	5GT	C9 H7 F3 N2 O	c1cc2c(cc1....
12	5T4V	ic50 = 60 nM	N48	C19 H17 N3 O4 S	CC1=CC(=O)....
13	5DYC	-	5GU	C8 H7 Br N2 O	c1cc2c(cc1....
14	5O55	-	9L5	C19 H23 N5 O2	CCN1c2ccc(....
15	5EQ1	Kd = 21 uM	BEA	C9 H8 N3 S	Cc1cccc2c1....
16	5G4S	ic50 = 1 uM	8VI	C24 H31 N5 O3	CCN(c1cc2c....
17	5EWC	-	5SJ	C12 H14 N2 O3	CCOC(=O)c1....
18	5EPR	Kd = 91 uM	5QY	C9 H10 N2 O	C[C@H]1C(=....
19	5EVA	-	5S9	C11 H9 F2 N3 O	Cn1c(ccn1)....
20	5ETD	-	5RN	C10 H9 N O	CC(=O)c1c[....
21	5DYA	-	5GV	C11 H12 N2 O3	CC[C@@H]1C....
22	5EV9	-	5SB	C14 H12 N4 O	CC(=O)Nc1c....
23	5MYG	Kd = 31 nM	LS8	C19 H17 N3 O4 S	CC1=Cc2cc(....
24	5MWZ	Kd = 7.1 uM	KGU	C24 H36 N6 O3	CCN1c2cc(c....
25	5G4R	ic50 = 7.943 nM	LF1	C22 H27 N5 O3	C[C@@H]1CN....
26	5OWA	Kd = 3.5 uM	B0H	C17 H24 N4 O2 S	Cc1c(oc(n1....
27	5EM3	-	5Q0	C9 H7 N O	c1cc2c(ccc....
28	5ETB	Kd = 29 uM	5RO	C11 H11 N O	Cc1cccc2c1....
29	4UYE	Kd = 9.54 nM	9F9	C22 H26 N4 O3	CN1c2cc(c(....
30	5O5F	-	9LT	C22 H20 F N5 O3	CCN1c2ccc(....
31	5O5A	-	9LN	C22 H21 N5 O3	CCN1c2ccc(....
32	5O5H	-	9LK	C17 H14 Cl N3 O3	Cc1c(oc(n1....
33	5C7N	Kd = 0.27 uM	BMF	C17 H20 N6 O4 S	CCOC(=O)Nc....
34	5EPS	Kd = 38 uM	5QX	C9 H10 N2 O	CN1c2ccccc....
35	5MWG	ic50 = 1.7 uM	WGX	C25 H30 N4 O4 S	CN1c2cc(c(....
36	5D7X	Kd = 15 uM	XZ8	C14 H13 N3 O2	CC1=C(C(=O....
37	6EKQ	Kd = 10.9 uM	B0H	C17 H24 N4 O2 S	Cc1c(oc(n1....

70% Homology Family (39)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 1331 families.
1	5E3G	-	5JQ	C5 H4 N4 O2 S	C12=C(NC(=....
2	5T4U	ic50 = 4800 nM	12Q	C10 H9 N O	CN1c2ccccc....
3	5EWH	Kd = 170 uM	5SG	C9 H7 N O	c1cc2cnccc....
4	5C85	Kd = 105 uM	4YO	C8 H7 Br N2 O	c1cc2c(cc1....
5	5E3D	Kd = 95 uM	5JL	C5 H4 N4 O S2	C12=C(NC(=....
6	5C87	-	4YS	C9 H7 N O	c1ccc2c(c1....
7	5O4T	-	9KT	C10 H10 N2 O2	CN1c2ccccc....
8	5OV8	Kd = 18 uM	AXN	C24 H30 N4 O4 S	CC(C)Cc1cc....
9	5O4S	ic50 = 3.4 uM	9KW	C24 H28 N4 O5 S	CN1c2cc(c(....
10	5MWH	Kd = 1.8 uM	UWX	C24 H30 N4 O5 S	CC(C)Cc1cc....
11	5DY7	-	5GT	C9 H7 F3 N2 O	c1cc2c(cc1....
12	5T4V	ic50 = 60 nM	N48	C19 H17 N3 O4 S	CC1=CC(=O)....
13	5DYC	-	5GU	C8 H7 Br N2 O	c1cc2c(cc1....
14	5O55	-	9L5	C19 H23 N5 O2	CCN1c2ccc(....
15	5EQ1	Kd = 21 uM	BEA	C9 H8 N3 S	Cc1cccc2c1....
16	5G4S	ic50 = 1 uM	8VI	C24 H31 N5 O3	CCN(c1cc2c....
17	5EWC	-	5SJ	C12 H14 N2 O3	CCOC(=O)c1....
18	5EPR	Kd = 91 uM	5QY	C9 H10 N2 O	C[C@H]1C(=....
19	5EVA	-	5S9	C11 H9 F2 N3 O	Cn1c(ccn1)....
20	5ETD	-	5RN	C10 H9 N O	CC(=O)c1c[....
21	5DYA	-	5GV	C11 H12 N2 O3	CC[C@@H]1C....
22	5EV9	-	5SB	C14 H12 N4 O	CC(=O)Nc1c....
23	5MYG	Kd = 31 nM	LS8	C19 H17 N3 O4 S	CC1=Cc2cc(....
24	5MWZ	Kd = 7.1 uM	KGU	C24 H36 N6 O3	CCN1c2cc(c....
25	5G4R	ic50 = 7.943 nM	LF1	C22 H27 N5 O3	C[C@@H]1CN....
26	5OWA	Kd = 3.5 uM	B0H	C17 H24 N4 O2 S	Cc1c(oc(n1....
27	5EM3	-	5Q0	C9 H7 N O	c1cc2c(ccc....
28	5ETB	Kd = 29 uM	5RO	C11 H11 N O	Cc1cccc2c1....
29	4UYE	Kd = 9.54 nM	9F9	C22 H26 N4 O3	CN1c2cc(c(....
30	5O5F	-	9LT	C22 H20 F N5 O3	CCN1c2ccc(....
31	5O5A	-	9LN	C22 H21 N5 O3	CCN1c2ccc(....
32	5O5H	-	9LK	C17 H14 Cl N3 O3	Cc1c(oc(n1....
33	5C7N	Kd = 0.27 uM	BMF	C17 H20 N6 O4 S	CCOC(=O)Nc....
34	5EPS	Kd = 38 uM	5QX	C9 H10 N2 O	CN1c2ccccc....
35	5MWG	ic50 = 1.7 uM	WGX	C25 H30 N4 O4 S	CN1c2cc(c(....
36	5D7X	Kd = 15 uM	XZ8	C14 H13 N3 O2	CC1=C(C(=O....
37	6EKQ	Kd = 10.9 uM	B0H	C17 H24 N4 O2 S	Cc1c(oc(n1....
38	3RCW	-	MB3	C5 H9 N O	CN1CCCC1=O
39	5N49	ic50 = 450 nM	8LW	C22 H17 N3 O3	Cc1cc2c(cc....

50% Homology Family (64)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 1144 families.
1	5I7Y	Kd = 52 nM	69G	C20 H21 N3 O2	C/C=C/CN1C....
2	4UIW	ic50 = 0.00000001 M	H1B	C22 H22 F3 N3 O3 S2	CCN1C=C(c2....
3	4UIV	ic50 = 0.00000001 M	XZB	C21 H20 F3 N3 O3 S2	CN1C=C(c2c....
4	5JI8	Kd = 23.4 uM	6KT	C8 H7 N3 O S	c1cc2c(cc1....
5	5MKY	ic50 = 2 uM	I0D	C15 H17 Cl N4 O	CN1CCc2c(c....
6	4UIU	ic50 = 0.00000001 M	TVU	C22 H24 N2 O6 S2	CN1C=C(c2c....
7	4UIT	ic50 = 0.00000001 M	N1D	C22 H25 N3 O6 S2	CN1C=C(c2c....
8	5I40	ic50 = 13.7 uM	67N	C8 H8 N2 O	CN1C=Cc2cc....
9	5I7X	Kd = 53 nM	67B	C17 H17 N3 O2	CN1C=C(c2c....
10	6V1B	Kd = 37 nM	H1B	C22 H22 F3 N3 O3 S2	CCN1C=C(c2....
11	6V0X	Kd = 277 uM	B49	C22 H27 F N4 O2	CCN(CC)CCN....
12	4XY8	Kd = 397 nM	43U	C12 H10 Br N5 O	COc1ccc(cc....
13	5IGM	Kd = 41.7 nM	BMF	C17 H20 N6 O4 S	CCOC(=O)Nc....
14	4Z6H	Kd = 612 nM	4L2	C16 H18 N2 O2	CC1=CC(=O)....
15	6HM0	Kd = 73 nM	GBW	C50 H64 N8 O9 S	Cc1c(scn1)....
16	5F1H	Kd = 14.1 nM	5U6	C20 H23 N3 O3	CN1C=C(c2c....
17	5F1L	ic50 = 21 nM	5U2	C19 H24 N2 O4	CC1=CC(=CN....
18	5F25	Kd = 9.1 uM	5TU	C14 H14 N2 O2	CC1=CC(=CN....
19	4Z6I	-	4L3	C27 H31 N3 O4	CC1=CC(=O)....
20	6V0S	Kd = 16000 nM	EAE	C13 H15 N O2 S	CCN1c2cc(c....
21	5EU1	Kd = 15.4 nM	5SW	C20 H23 N3 O3	CN1C=C(c2c....
22	6V14	Kd = 82 nM	QMG	C20 H19 N3 O2	Cc1ccc(cc1....
23	5F2P	Kd = 37.5 uM	5TY	C10 H12 N4 O	CN1C=Cc2c(....
24	5E3D	Kd = 95 uM	5JL	C5 H4 N4 O S2	C12=C(NC(=....
25	5C87	-	4YS	C9 H7 N O	c1ccc2c(c1....
26	5O4T	-	9KT	C10 H10 N2 O2	CN1c2ccccc....
27	5OV8	Kd = 18 uM	AXN	C24 H30 N4 O4 S	CC(C)Cc1cc....
28	5O4S	ic50 = 3.4 uM	9KW	C24 H28 N4 O5 S	CN1c2cc(c(....
29	5MWH	Kd = 1.8 uM	UWX	C24 H30 N4 O5 S	CC(C)Cc1cc....
30	5DY7	-	5GT	C9 H7 F3 N2 O	c1cc2c(cc1....
31	5T4V	ic50 = 60 nM	N48	C19 H17 N3 O4 S	CC1=CC(=O)....
32	5DYC	-	5GU	C8 H7 Br N2 O	c1cc2c(cc1....
33	5O55	-	9L5	C19 H23 N5 O2	CCN1c2ccc(....
34	5EQ1	Kd = 21 uM	BEA	C9 H8 N3 S	Cc1cccc2c1....
35	5G4S	ic50 = 1 uM	8VI	C24 H31 N5 O3	CCN(c1cc2c....
36	5EWC	-	5SJ	C12 H14 N2 O3	CCOC(=O)c1....
37	5EPR	Kd = 91 uM	5QY	C9 H10 N2 O	C[C@H]1C(=....
38	5EVA	-	5S9	C11 H9 F2 N3 O	Cn1c(ccn1)....
39	5ETD	-	5RN	C10 H9 N O	CC(=O)c1c[....
40	5DYA	-	5GV	C11 H12 N2 O3	CC[C@@H]1C....
41	5EV9	-	5SB	C14 H12 N4 O	CC(=O)Nc1c....
42	5MYG	Kd = 31 nM	LS8	C19 H17 N3 O4 S	CC1=Cc2cc(....
43	5MWZ	Kd = 7.1 uM	KGU	C24 H36 N6 O3	CCN1c2cc(c....
44	5G4R	ic50 = 7.943 nM	LF1	C22 H27 N5 O3	C[C@@H]1CN....
45	5OWA	Kd = 3.5 uM	B0H	C17 H24 N4 O2 S	Cc1c(oc(n1....
46	5EM3	-	5Q0	C9 H7 N O	c1cc2c(ccc....
47	5ETB	Kd = 29 uM	5RO	C11 H11 N O	Cc1cccc2c1....
48	4UYE	Kd = 9.54 nM	9F9	C22 H26 N4 O3	CN1c2cc(c(....
49	5O5F	-	9LT	C22 H20 F N5 O3	CCN1c2ccc(....
50	5O5A	-	9LN	C22 H21 N5 O3	CCN1c2ccc(....
51	5O5H	-	9LK	C17 H14 Cl N3 O3	Cc1c(oc(n1....
52	5C7N	Kd = 0.27 uM	BMF	C17 H20 N6 O4 S	CCOC(=O)Nc....
53	5EPS	Kd = 38 uM	5QX	C9 H10 N2 O	CN1c2ccccc....
54	5MWG	ic50 = 1.7 uM	WGX	C25 H30 N4 O4 S	CN1c2cc(c(....
55	5D7X	Kd = 15 uM	XZ8	C14 H13 N3 O2	CC1=C(C(=O....
56	6EKQ	Kd = 10.9 uM	B0H	C17 H24 N4 O2 S	Cc1c(oc(n1....
57	6V1E	Kd = 121 nM	5SW	C20 H23 N3 O3	CN1C=C(c2c....
58	6V17	Kd = 148 nM	H1B	C22 H22 F3 N3 O3 S2	CCN1C=C(c2....
59	6V0Q	Kd = 4200 nM	EAE	C13 H15 N O2 S	CCN1c2cc(c....
60	6V1H	Kd = 114 nM	BMF	C17 H20 N6 O4 S	CCOC(=O)Nc....
61	6V16	Kd = 556 nM	QMG	C20 H19 N3 O2	Cc1ccc(cc1....
62	6V1F	Kd = 418 nM	5U6	C20 H23 N3 O3	CN1C=C(c2c....
63	3RCW	-	MB3	C5 H9 N O	CN1CCCC1=O
64	5N49	ic50 = 450 nM	8LW	C22 H17 N3 O3	Cc1cc2c(cc....

Polypharmacology

Similar Ligands (2D)

Ligand no: 1; Ligand: 4YS; Similar ligands found: 2

No:	Ligand	ECFP6 Tc	MDL keys Tc
1	4YS	1	1
2	KUF	0.434783	0.958333

Similar Ligands (3D)

Ligand no: 1; Ligand: 4YS; Similar ligands found: 1128

No:	Ligand	Similarity coefficient
1	1LQ	1.0000
2	ES1	1.0000
3	O72	1.0000
4	1SQ	1.0000
5	1NP	1.0000
6	HQY	1.0000
7	JPZ	1.0000
8	1LM	1.0000
9	JBH	1.0000
10	N5J	1.0000
11	24W	1.0000
12	5Q0	0.9999
13	5IQ	0.9998
14	5SG	0.9995
15	4XH	0.9907
16	HH8	0.9904
17	SVN	0.9836
18	HPA	0.9835
19	ADE	0.9817
20	1XN	0.9807
21	QUZ	0.9806
22	Q88	0.9805
23	ISN	0.9801
24	NPY	0.9790
25	BTE	0.9789
26	GLC	0.9789
27	12Q	0.9783
28	7WA	0.9767
29	10L	0.9766
30	6MP	0.9766
31	BGC	0.9764
32	XYP	0.9764
33	KKN	0.9762
34	KJH	0.9760
35	SAL	0.9759
36	9HX	0.9756
37	9DA	0.9755
38	9EW	0.9754
39	AZ8	0.9752
40	R8V	0.9751
41	0P6	0.9747
42	3WA	0.9747
43	JBQ	0.9743
44	7HP	0.9741
45	ES0	0.9740
46	5WV	0.9738
47	BP1	0.9729
48	MT0	0.9728
49	A7W	0.9728
50	HQT	0.9725
51	F05	0.9725
52	PXL	0.9722
53	ES7	0.9721
54	SWD	0.9720
55	7W4	0.9719
56	32X	0.9719
57	9DG	0.9719
58	6M9	0.9717
59	CWM	0.9716
60	AZA	0.9716
61	7W1	0.9716
62	Q24	0.9711
63	6M4	0.9711
64	M1A	0.9709
65	PE0	0.9708
66	495	0.9706
67	67N	0.9705
68	CWS	0.9705
69	LXC	0.9704
70	JBE	0.9703
71	M1Q	0.9699
72	GUN	0.9696
73	XAN	0.9696
74	25W	0.9695
75	M6N	0.9694
76	PM6	0.9692
77	1PT	0.9691
78	5QX	0.9690
79	TTL	0.9690
80	0RW	0.9689
81	8CM	0.9686
82	HLR	0.9686
83	I3A	0.9685
84	DHQ	0.9685
85	J9W	0.9684
86	AQO	0.9683
87	IGA	0.9683
88	2D0	0.9682
89	MEW	0.9682
90	AJ2	0.9681
91	ADZ	0.9680
92	CFP	0.9679
93	M5K	0.9677
94	4HC	0.9674
95	7HQ	0.9672
96	G6D	0.9672
97	ES4	0.9668
98	5RG	0.9663
99	HZQ	0.9662
100	SKA	0.9648
101	23A	0.9643
102	3Z8	0.9640
103	DIN	0.9638
104	EQT	0.9635
105	UNC	0.9635
106	7B4	0.9632
107	3HA	0.9632
108	MRW	0.9631
109	A2F	0.9629
110	141	0.9626
111	6AP	0.9619
112	DEN	0.9617
113	3ID	0.9615
114	3M0	0.9614
115	2CK	0.9613
116	BHO	0.9612
117	KT7	0.9611
118	HLZ	0.9610
119	M1H	0.9610
120	290	0.9604
121	3F0	0.9604
122	5WX	0.9604
123	AZ9	0.9602
124	URC	0.9602
125	AHR	0.9600
126	DX4	0.9595
127	FOT	0.9595
128	ES6	0.9591
129	3U4	0.9589
130	XXR	0.9588
131	9MG	0.9586
132	G3F	0.9586
133	BE2	0.9585
134	4SV	0.9581
135	DBJ	0.9580
136	AZG	0.9580
137	HJP	0.9579
138	0W8	0.9576
139	4CS	0.9573
140	M0Q	0.9570
141	DBH	0.9567
142	3PF	0.9565
143	JKE	0.9564
144	SWA	0.9562
145	7VS	0.9560
146	GTQ	0.9557
147	GIO	0.9557
148	1WD	0.9548
149	1P7	0.9546
150	3IT	0.9546
151	JBK	0.9542
152	FE DB1	0.9540
153	ORO	0.9540
154	COU	0.9533
155	4JP	0.9530
156	G3E	0.9528
157	8S0	0.9526
158	JUG	0.9522
159	DMD	0.9520
160	BDP	0.9517
161	BOA	0.9516
162	XM0	0.9516
163	5M0	0.9515
164	4NC	0.9514
165	7WV	0.9513
166	APZ	0.9511
167	YH7	0.9510
168	8GC	0.9509
169	1XM	0.9508
170	DRL	0.9508
171	7NI	0.9506
172	GCS	0.9503
173	HH5	0.9502
174	3HB	0.9501
175	03V	0.9496
176	IND	0.9495
177	LSA	0.9494
178	BTY	0.9492
179	XYS	0.9492
180	XQ0	0.9489
181	GAB	0.9488
182	6CS	0.9488
183	JB5	0.9487
184	BZX	0.9486
185	BZI	0.9486
186	2AQ	0.9485
187	BCP	0.9485
188	M1E	0.9484
189	OXC	0.9483
190	H42	0.9482
191	IJZ	0.9481
192	AX7	0.9481
193	GRE	0.9481
194	QBK	0.9480
195	SOE	0.9480
196	4FS	0.9477
197	BZF	0.9476
198	GVH	0.9475
199	ISE	0.9474
200	B60	0.9473
201	0N7	0.9471
202	VK3	0.9469
203	OCH	0.9467
204	CTL	0.9467
205	EA1	0.9466
206	DHB	0.9465
207	75K	0.9464
208	Q6T	0.9463
209	FDB	0.9463
210	8TX	0.9463
211	MUA	0.9458
212	5CU	0.9458
213	54G	0.9457
214	IDM	0.9457
215	5NU	0.9456
216	270	0.9455
217	HQD	0.9454
218	0R1	0.9454
219	ABV	0.9452
220	86J	0.9451
221	G1O	0.9450
222	F60	0.9449
223	14O	0.9449
224	VNL	0.9449
225	5QY	0.9449
226	39A	0.9447
227	B55	0.9447
228	5B1	0.9444
229	RXA	0.9444
230	NQ	0.9444
231	ES5	0.9442
232	5H1	0.9441
233	HHA	0.9440
234	B53	0.9436
235	1WG	0.9435
236	LZ1	0.9434
237	MAQ	0.9433
238	MPI	0.9432
239	GAL	0.9429
240	YCP	0.9428
241	2ZV	0.9425
242	6AI	0.9425
243	B62	0.9425
244	6PC	0.9425
245	5HN	0.9424
246	AKH	0.9423
247	42C	0.9422
248	5MI	0.9420
249	0FO	0.9420
250	ADK	0.9418
251	5MB	0.9417
252	6F0	0.9417
253	GYE	0.9417
254	MO8	0.9416
255	D1X	0.9415
256	SE2	0.9414
257	0CT	0.9413
258	2K4	0.9409
259	BEZ	0.9409
260	XAZ	0.9405
261	0CU	0.9404
262	C2U	0.9403
263	XHP	0.9402
264	FA0	0.9402
265	NOJ	0.9402
266	3NT	0.9401
267	3AB	0.9401
268	150	0.9401
269	6M1	0.9400
270	8IG	0.9400
271	BEN	0.9399
272	RSF	0.9399
273	5JQ	0.9397
274	D48	0.9396
275	BAM	0.9395
276	DOR	0.9395
277	GDE	0.9394
278	9TZ	0.9392
279	PYQ	0.9390
280	IV2	0.9389
281	G5V	0.9387
282	92K	0.9386
283	2MI	0.9383
284	RAM	0.9381
285	3MA	0.9380
286	4MU	0.9380
287	YSO	0.9379
288	URF	0.9379
289	5RN	0.9379
290	J5I	0.9378
291	DOB	0.9375
292	NCA	0.9374
293	2HQ	0.9373
294	0TR	0.9373
295	4AA	0.9372
296	P9P	0.9371
297	53C	0.9371
298	12B	0.9370
299	34D	0.9370
300	2CQ	0.9369
301	ARB	0.9369
302	DQU	0.9367
303	42A	0.9367
304	QX4	0.9365
305	MCT	0.9363
306	5MK	0.9361
307	L3Q	0.9359
308	BEA	0.9359
309	INO	0.9359
310	AJV	0.9358
311	DHK	0.9357
312	4XR	0.9357
313	OVV	0.9356
314	FUL	0.9356
315	M0W	0.9355
316	NBZ	0.9351
317	173	0.9351
318	GBD	0.9349
319	SX1	0.9348
320	WCE	0.9348
321	AW5	0.9347
322	4A3	0.9347
323	ASO	0.9347
324	ES9	0.9345
325	LT2	0.9345
326	NIO	0.9343
327	TEP	0.9342
328	7ZE	0.9342
329	BHA	0.9340
330	JZ9	0.9340
331	GAG	0.9339
332	44W	0.9338
333	EXO	0.9337
334	OXQ	0.9336
335	2ZQ	0.9336
336	0MK	0.9336
337	LZM	0.9335
338	NTM	0.9335
339	4M0	0.9334
340	XX2	0.9332
341	MYJ	0.9332
342	NNO	0.9332
343	XQG	0.9330
344	2AK	0.9329
345	OTW	0.9328
346	WBU	0.9324
347	BRT	0.9324
348	TDR	0.9323
349	FHB	0.9321
350	NK	0.9319
351	PHT	0.9317
352	UNU	0.9316
353	PZA	0.9315
354	5JL	0.9314
355	JAE	0.9311
356	NDH	0.9310
357	B57	0.9309
358	F5B	0.9307
359	4HO	0.9306
360	TOF	0.9305
361	9KT	0.9305
362	1DW	0.9305
363	11S	0.9304
364	H4N	0.9303
365	5WY	0.9303
366	XBZ	0.9302
367	3HM	0.9301
368	HMH	0.9301
369	FK1	0.9299
370	3BZ	0.9298
371	93K	0.9298
372	TH7	0.9297
373	FYU	0.9297
374	GCU	0.9294
375	F0J	0.9292
376	MWM	0.9291
377	CFF	0.9291
378	44V	0.9290
379	7CZ	0.9289
380	E7Z	0.9288
381	PZI	0.9287
382	4ZE	0.9286
383	VGL	0.9285
384	2HO	0.9280
385	CHB	0.9279
386	BE7	0.9278
387	6ME	0.9278
388	MVN	0.9277
389	NDM	0.9276
390	4JT	0.9276
391	2YU	0.9274
392	2AC	0.9273
393	VNJ	0.9271
394	HY3	0.9271
395	KJY	0.9270
396	MWP	0.9269
397	SXS	0.9267
398	15L	0.9266
399	P3K	0.9265
400	S76	0.9265
401	2MP	0.9263
402	SKM	0.9263
403	INS	0.9262
404	DIE	0.9261
405	JIF	0.9260
406	ICP	0.9260
407	RIP	0.9260
408	2FG	0.9260
409	HFB	0.9259
410	SS1	0.9259
411	QSB	0.9258
412	A1U	0.9256
413	34A	0.9256
414	PFB	0.9256
415	KIB	0.9253
416	KYD	0.9252
417	LGC	0.9252
418	NMJ	0.9252
419	V55	0.9249
420	3RK	0.9249
421	5AC	0.9248
422	37T	0.9245
423	1MC	0.9245
424	8WT	0.9245
425	XYD	0.9244
426	4M4	0.9244
427	HIS	0.9244
428	CTS	0.9243
429	TH0	0.9242
430	43M	0.9241
431	5OB	0.9241
432	60P	0.9239
433	TM7	0.9239
434	GTR	0.9239
435	PYD	0.9238
436	DIU	0.9238
437	D07	0.9237
438	4ME	0.9237
439	3Z7	0.9236
440	8NY	0.9235
441	2A7	0.9234
442	JZ3	0.9233
443	NTN	0.9232
444	NPO	0.9230
445	6GU	0.9228
446	5UC	0.9226
447	2H5	0.9226
448	64K	0.9226
449	9TW	0.9225
450	ET2	0.9225
451	FUC	0.9225
452	KLW	0.9223
453	P92	0.9220
454	FBB	0.9219
455	4JJ	0.9218
456	PYG	0.9217
457	3MC	0.9217
458	2AL	0.9217
459	RM1	0.9210
460	149	0.9209
461	7MH	0.9206
462	NID	0.9203
463	AC0	0.9203
464	4CL	0.9201
465	FBT	0.9200
466	3MB	0.9200
467	UEG	0.9200
468	ZVO	0.9199
469	KJU	0.9199
470	45C	0.9197
471	36R	0.9196
472	OVM	0.9196
473	GLA	0.9196
474	SHA	0.9193
475	1P3	0.9192
476	SHG	0.9192
477	7VJ	0.9191
478	PBC	0.9190
479	RM4	0.9190
480	4Z4	0.9189
481	MBD	0.9189
482	4JQ	0.9189
483	JZ2	0.9188
484	7ME	0.9188
485	INE	0.9186
486	1P8	0.9185
487	HMU	0.9182
488	NIZ	0.9181
489	3ZQ	0.9180
490	ICO	0.9179
491	2C9	0.9179
492	HT4	0.9176
493	ES2	0.9176
494	CLW	0.9173
495	MZG	0.9171
496	2EC	0.9170
497	F4Z	0.9170
498	GJS	0.9169
499	FBV	0.9168
500	FLM	0.9167
501	6MH	0.9165
502	PHB	0.9165
503	BR9	0.9164
504	6VD	0.9162
505	NOY	0.9162
506	FGZ	0.9161
507	F31	0.9161
508	J9Q	0.9160
509	ZZT	0.9159
510	IHB	0.9158
511	82I	0.9158
512	EKZ	0.9157
513	5MH	0.9156
514	KOJ	0.9156
515	3OC	0.9154
516	DUB	0.9153
517	N8Y	0.9152
518	CFI	0.9152
519	BCF	0.9151
520	K2T	0.9151
521	PXM	0.9151
522	97T	0.9151
523	5RO	0.9151
524	MQN	0.9150
525	MWJ	0.9150
526	A13	0.9149
527	GMN	0.9147
528	DBX	0.9146
529	NTZ	0.9146
530	JXN	0.9144
531	24B	0.9143
532	WOO	0.9142
533	QPR	0.9141
534	FCB	0.9141
535	RMN	0.9141
536	QSC	0.9140
537	5VM	0.9140
538	FCA	0.9140
539	SRO	0.9140
540	27Y	0.9139
541	QSH	0.9138
542	3FA	0.9137
543	3DO	0.9137
544	PA1	0.9135
545	329	0.9134
546	35C	0.9133
547	DPZ	0.9132
548	LI6	0.9132
549	TTY	0.9132
550	J9T	0.9131
551	680	0.9131
552	MFB	0.9131
553	DFB	0.9131
554	UAN	0.9130
555	TC7	0.9129
556	5JC	0.9128
557	T6C	0.9128
558	ISZ	0.9128
559	DNF	0.9128
560	MAN	0.9128
561	2MY	0.9127
562	IFL	0.9125
563	4YO	0.9123
564	VGD	0.9122
565	8OZ	0.9122
566	EVA	0.9122
567	FFP	0.9121
568	R8A	0.9121
569	J1Z	0.9120
570	ALL	0.9120
571	3SK	0.9119
572	LKA	0.9119
573	JFD	0.9118
574	AZF	0.9118
575	OAA	0.9118
576	BBF	0.9117
577	3MG	0.9117
578	KBG	0.9115
579	ARA	0.9112
580	GM7	0.9111
581	DQN	0.9110
582	4ZC	0.9110
583	7B3	0.9108
584	EYK	0.9108
585	0TU	0.9107
586	G2F	0.9107
587	RNS	0.9107
588	5GU	0.9106
589	SYV	0.9105
590	0JD	0.9105
591	GIV	0.9105
592	CLZ	0.9103
593	2FQ	0.9102
594	12M	0.9102
595	F12	0.9101
596	Q7A	0.9099
597	51R	0.9098
598	PAB	0.9097
599	4JO	0.9096
600	2CM	0.9096
601	NSP	0.9096
602	3FH	0.9095
603	IT2	0.9095
604	0FN	0.9092
605	Z82	0.9092
606	FAN	0.9090
607	IFM	0.9090
608	3DM	0.9090
609	SOR	0.9089
610	PCI	0.9086
611	3CE	0.9081
612	HBD	0.9081
613	6RQ	0.9080
614	X05	0.9080
615	QAT	0.9080
616	X09	0.9080
617	GOG	0.9079
618	8H8	0.9079
619	39O	0.9078
620	DFU	0.9078
621	QWN	0.9076
622	ASC	0.9076
623	1Y6	0.9073
624	YQA	0.9073
625	IFP	0.9072
626	QAS	0.9071
627	GCB	0.9071
628	SJ5	0.9068
629	GZ8	0.9067
630	R9Y	0.9066
631	QOS	0.9065
632	TLD	0.9065
633	G4D	0.9065
634	MS9	0.9061
635	I1N	0.9061
636	8WO	0.9060
637	23J	0.9060
638	5CL	0.9059
639	FB1	0.9059
640	BZ3	0.9058
641	1GN	0.9058
642	LDP	0.9056
643	2DR	0.9055
644	PHH	0.9054
645	9FL	0.9054
646	GOO	0.9052
647	A29	0.9050
648	PBZ	0.9048
649	TIU	0.9047
650	M2K	0.9046
651	IUR	0.9046
652	826	0.9045
653	F81	0.9042
654	IBF	0.9040
655	F3B	0.9038
656	5XC	0.9038
657	BR8	0.9038
658	Q71	0.9037
659	BMA	0.9036
660	RPQ	0.9034
661	40O	0.9034
662	Z5P	0.9032
663	IPB	0.9030
664	EUG	0.9029
665	LCN	0.9027
666	286	0.9026
667	0R0	0.9023
668	PRF	0.9023
669	GAF	0.9023
670	4MA	0.9021
671	FPY	0.9021
672	JND	0.9020
673	QXW	0.9019
674	HX3	0.9019
675	PQ0	0.9017
676	GZL	0.9016
677	3XX	0.9015
678	OXE	0.9014
679	HNQ	0.9012
680	R8S	0.9011
681	X0V	0.9011
682	MBG	0.9009
683	GVG	0.9008
684	OW4	0.9007
685	X6X	0.9007
686	CAQ	0.9007
687	209	0.9006
688	XCZ	0.9005
689	YTB	0.9005
690	282	0.9001
691	7WR	0.8997
692	FBW	0.8996
693	RIB	0.8995
694	M58	0.8993
695	FPK	0.8993
696	15E	0.8993
697	20J	0.8993
698	RSO	0.8991
699	GXY	0.8989
700	DGJ	0.8988
701	OMD	0.8987
702	H33	0.8985
703	ADA	0.8985
704	KBB	0.8982
705	AFR	0.8982
706	174	0.8982
707	Y8I	0.8981
708	OA3	0.8978
709	PX7	0.8977
710	FBG	0.8976
711	8ZE	0.8976
712	94N	0.8974
713	F9P	0.8974
714	CN0	0.8973
715	4P5	0.8972
716	ASP	0.8972
717	B5D	0.8971
718	AJY	0.8970
719	3MH	0.8970
720	URQ	0.8970
721	1M2	0.8969
722	261	0.8969
723	MR1	0.8968
724	OXZ	0.8966
725	4TU	0.8965
726	FUF	0.8962
727	XIY	0.8962
728	13X	0.8960
729	AC6	0.8960
730	BK9	0.8957
731	FPI	0.8956
732	ZZ3	0.8955
733	SYN	0.8955
734	FBU	0.8955
735	UFO	0.8955
736	AX2	0.8954
737	GXL	0.8954
738	8XQ	0.8954
739	2FY	0.8953
740	TBP	0.8951
741	PRZ	0.8951
742	TBS	0.8950
743	AMC	0.8948
744	IDH	0.8947
745	NK2	0.8946
746	6UA	0.8944
747	MLT	0.8944
748	L99	0.8943
749	PRO	0.8943
750	PHU	0.8941
751	PAF	0.8941
752	HBX	0.8940
753	4SX	0.8939
754	XXP	0.8939
755	VOH	0.8938
756	TGX	0.8937
757	4HM	0.8936
758	HBA	0.8936
759	FP1	0.8935
760	YIO	0.8935
761	PBA	0.8935
762	1U6	0.8934
763	EJZ	0.8931
764	RHU	0.8930
765	L89	0.8930
766	MVL	0.8930
767	I6G	0.8928
768	HXX	0.8928
769	PDC	0.8928
770	284	0.8927
771	717	0.8925
772	K17	0.8924
773	9CA	0.8924
774	8W9	0.8921
775	7MU	0.8919
776	1KP	0.8918
777	5NE	0.8918
778	FBM	0.8918
779	2AF	0.8918
780	2A9	0.8917
781	WDL	0.8916
782	BEW	0.8914
783	N2I	0.8914
784	IPZ	0.8914
785	IF7	0.8913
786	2MN	0.8912
787	FLV	0.8911
788	069	0.8911
789	RCO	0.8911
790	KIA	0.8909
791	260	0.8909
792	FB2	0.8909
793	3AY	0.8908
794	4XV	0.8907
795	QIC	0.8907
796	3R6	0.8906
797	92Z	0.8905
798	APG	0.8905
799	UFV	0.8903
800	URA	0.8903
801	226	0.8902
802	GOX	0.8901
803	ABE	0.8900
804	2CH	0.8900
805	NEQ	0.8900
806	FP2	0.8899
807	3NY	0.8899
808	JA8	0.8898
809	PEY	0.8896
810	JZ0	0.8895
811	QX2	0.8895
812	8LG	0.8892
813	1AN	0.8890
814	K5W	0.8888
815	PAC	0.8888
816	SVD	0.8888
817	2PC	0.8887
818	0HO	0.8886
819	265	0.8886
820	275	0.8885
821	P72	0.8884
822	2BG	0.8884
823	MZB	0.8884
824	HKD	0.8883
825	6NT	0.8883
826	SYA	0.8882
827	LG3	0.8882
828	FDK	0.8881
829	FOA	0.8880
830	SW7	0.8879
831	ABN	0.8877
832	BSP	0.8876
833	PYF	0.8876
834	4FH	0.8876
835	95Z	0.8875
836	1IT	0.8874
837	LYL	0.8874
838	PYC	0.8874
839	TWO	0.8873
840	GLF	0.8872
841	SRT	0.8872
842	HQJ	0.8872
843	JTH	0.8872
844	JG8	0.8871
845	CRS	0.8870
846	AIN	0.8870
847	ZYR	0.8867
848	CYT	0.8867
849	ENL	0.8867
850	52C	0.8867
851	PY7	0.8866
852	MSN	0.8866
853	0LH	0.8865
854	C21	0.8865
855	XBT	0.8865
856	ZWZ	0.8864
857	76X	0.8864
858	ERH	0.8862
859	AEZ	0.8862
860	4PW	0.8861
861	9TY	0.8861
862	DMJ	0.8860
863	MAK	0.8860
864	VXX	0.8860
865	SMV	0.8860
866	DEE	0.8859
867	3CH	0.8858
868	PH2	0.8857
869	X8D	0.8854
870	TP5	0.8854
871	93Q	0.8852
872	DYA	0.8852
873	GLY PRO	0.8852
874	LG5	0.8851
875	0F9	0.8851
876	MNM	0.8850
877	5ZE	0.8850
878	3C1	0.8850
879	LMR	0.8849
880	2LP	0.8848
881	94B	0.8846
882	TPA	0.8846
883	JZ1	0.8845
884	26D	0.8845
885	EV0	0.8844
886	0HN	0.8844
887	FA3	0.8843
888	GV9	0.8840
889	2ZX	0.8839
890	92P	0.8839
891	4XS	0.8837
892	TLA	0.8836
893	GIM	0.8836
894	HHR	0.8833
895	2ZM	0.8833
896	GCO	0.8832
897	FDR	0.8831
898	HTS	0.8831
899	3C2	0.8830
900	WOT	0.8830
901	ZZ8	0.8830
902	MT5	0.8830
903	TAR	0.8829
904	FCR	0.8829
905	4VP	0.8829
906	XUL	0.8828
907	HIO	0.8826
908	TM4	0.8825
909	E3D	0.8825
910	TSS	0.8822
911	6KX	0.8821
912	ODO	0.8821
913	HA7	0.8821
914	AS3	0.8817
915	9RW	0.8815
916	MHK	0.8815
917	KIV	0.8815
918	ROI	0.8815
919	TZC	0.8814
920	2LY	0.8813
921	06B	0.8812
922	K34	0.8812
923	JBN	0.8812
924	G12	0.8812
925	OVP	0.8811
926	XYL	0.8810
927	C2Y	0.8809
928	PMB	0.8809
929	N8P	0.8809
930	PHE	0.8808
931	KDV	0.8807
932	ZB1	0.8807
933	RB5	0.8806
934	BPU	0.8805
935	9R5	0.8805
936	BVF	0.8802
937	F9Y	0.8801
938	Q77	0.8800
939	GIF	0.8799
940	DX3	0.8798
941	JLZ	0.8797
942	938	0.8796
943	28N	0.8796
944	AUD	0.8796
945	FH2	0.8794
946	18N	0.8794
947	QWW	0.8790
948	K6X	0.8790
949	2HU	0.8790
950	6LW	0.8790
951	1XX	0.8789
952	091	0.8789
953	GT0	0.8789
954	BDF	0.8788
955	2PG	0.8788
956	5NI	0.8786
957	2MH	0.8786
958	47J	0.8784
959	8GF	0.8783
960	TSU	0.8783
961	TFU	0.8781
962	948	0.8780
963	TT4	0.8779
964	1X7	0.8778
965	YAN	0.8778
966	GLT	0.8777
967	3SL	0.8777
968	BCU	0.8776
969	IP0	0.8774
970	FA1	0.8774
971	JU2	0.8771
972	KPL	0.8768
973	NCT	0.8768
974	ABI	0.8766
975	NVU	0.8766
976	JKZ	0.8766
977	C2A	0.8766
978	SMN	0.8766
979	PLQ	0.8763
980	23W	0.8763
981	OK7	0.8762
982	HTP	0.8760
983	6BL	0.8759
984	273	0.8757
985	6OT	0.8756
986	ZBT	0.8755
987	CWJ	0.8754
988	N7P	0.8753
989	URP	0.8751
990	1MR	0.8750
991	4WL	0.8749
992	FRU	0.8747
993	1F1	0.8744
994	SAN	0.8744
995	ZZZ	0.8742
996	BNS	0.8741
997	AAS	0.8741
998	8GK	0.8741
999	FQI	0.8739
1000	JAB	0.8738
1001	CGB	0.8736
1002	AGK	0.8735
1003	2XX	0.8734
1004	CXF	0.8734
1005	3A9	0.8733
1006	K32	0.8730
1007	2KA	0.8729
1008	SF9	0.8729
1009	L5V	0.8727
1010	4P0	0.8725
1011	NGO	0.8725
1012	0XT	0.8724
1013	HQE	0.8721
1014	FPN	0.8720
1015	LDR	0.8720
1016	ESI	0.8719
1017	H8N	0.8718
1018	14J	0.8717
1019	6X8	0.8717
1020	ONR	0.8717
1021	GCV	0.8716
1022	PCR	0.8716
1023	H3M	0.8716
1024	7D2	0.8715
1025	DNC	0.8715
1026	D3M	0.8715
1027	ECE	0.8713
1028	ZXD	0.8712
1029	PBE	0.8711
1030	B3R	0.8711
1031	94W	0.8710
1032	BNT	0.8705
1033	MXN	0.8703
1034	JZ5	0.8703
1035	MRZ	0.8702
1036	AMG	0.8702
1037	HDH	0.8701
1038	MFU	0.8701
1039	DHS	0.8700
1040	M2H	0.8700
1041	6HQ	0.8700
1042	DA1	0.8700
1043	K22	0.8700
1044	CIG	0.8699
1045	7N0	0.8694
1046	6NI	0.8693
1047	LNR	0.8692
1048	TCZ	0.8690
1049	LG4	0.8690
1050	285	0.8688
1051	PD2	0.8684
1052	YHO	0.8683
1053	JXW	0.8682
1054	HEW	0.8682
1055	HGQ	0.8681
1056	GTZ	0.8680
1057	4ZA	0.8678
1058	TMZ	0.8676
1059	M3T	0.8675
1060	4H2	0.8672
1061	GCW	0.8671
1062	3AL	0.8670
1063	JXZ	0.8670
1064	EDR	0.8669
1065	25R	0.8667
1066	0W1	0.8666
1067	PXY	0.8666
1068	1DU	0.8666
1069	M5N	0.8660
1070	LRH	0.8650
1071	PKU	0.8650
1072	O2A	0.8649
1073	9AP	0.8647
1074	8HC	0.8644
1075	1XA	0.8644
1076	9PY	0.8641
1077	BZ2	0.8640
1078	H6B	0.8640
1079	EOL	0.8637
1080	ASN	0.8633
1081	DUC	0.8632
1082	FBA	0.8630
1083	4RU	0.8630
1084	PIM	0.8629
1085	0FK	0.8627
1086	1AL	0.8627
1087	4JM	0.8627
1088	GTL	0.8627
1089	HA5	0.8627
1090	A09	0.8625
1091	1DV	0.8623
1092	XXG	0.8620
1093	PCA	0.8617
1094	2TQ	0.8615
1095	1DQ	0.8615
1096	TZE	0.8613
1097	DHR	0.8612
1098	5NS	0.8612
1099	ANN	0.8612
1100	TMT	0.8607
1101	PEP	0.8606
1102	4CH	0.8605
1103	H62	0.8605
1104	PFL	0.8604
1105	KFH	0.8601
1106	FBS	0.8600
1107	QMP	0.8596
1108	CRN	0.8592
1109	9FE	0.8586
1110	H76	0.8582
1111	AEF	0.8581
1112	PBR	0.8580
1113	1LN	0.8576
1114	HLD	0.8575
1115	H7Y	0.8572
1116	HHQ	0.8569
1117	MMA	0.8565
1118	DQA	0.8565
1119	4HS	0.8564
1120	R2B	0.8563
1121	SS2	0.8563
1122	1HN	0.8562
1123	X0W	0.8558
1124	3TJ	0.8558
1125	II6	0.8557
1126	RUU	0.8553
1127	0GZ	0.8532
1128	E1T	0.8522

Similar Binding Sites (Proteins are less than 50% similar to leader)

Pocket No.: 1; Query (leader) PDB : 4UYE; Ligand: 9F9; Similar sites found with APoc: 4

This union binding pocket(no: 1) in the query (biounit: 4uye.bio1) has 19 residues
No:	Leader PDB	Ligand	Sequence Similarity
1	4YC9	4C1	35.5932
2	6J3O	B4L	38.1356
3	5MLJ	9ST	40.1786
4	5ML0	P2L	45.4545

Pocket No.: 2; Query (leader) PDB : 4UYE; Ligand: 9F9; Similar sites found with APoc: 7

This union binding pocket(no: 2) in the query (biounit: 4uye.bio2) has 16 residues
No:	Leader PDB	Ligand	Sequence Similarity
1	6J3P	B8O	38.1356
2	6J3O	B4L	38.1356
3	6J3P	B8O	38.1356
4	5TPX	7H7	38.9831
5	5MLJ	9ST	40.1786
6	5MLJ	9ST	40.1786
7	5ML0	P2L	45.4545

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