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Receptor
PDB id Resolution Class Description Source Keywords
5E8J 2.35 Å EC: 2.1.1.56 CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASE I WITH RAM HOMO SAPIENS MRNA CAPPING MRNA PROCESSING TRANSLATION
Ref.: MOLECULAR BASIS OF RNA GUANINE-7 METHYLTRANSFERASE ACTIVATION BY RAM. NUCLEIC ACIDS RES. V. 44 10423 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAH B:501;
A:502;
Valid;
Valid;
none;
none;
submit data
384.411 C14 H20 N6 O5 S c1nc(...
GOL A:501;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5E8J 2.35 Å EC: 2.1.1.56 CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASE I WITH RAM HOMO SAPIENS MRNA CAPPING MRNA PROCESSING TRANSLATION
Ref.: MOLECULAR BASIS OF RNA GUANINE-7 METHYLTRANSFERASE ACTIVATION BY RAM. NUCLEIC ACIDS RES. V. 44 10423 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5E8J - SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5E8J - SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5E8J - SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5E8J; Ligand: SAH; Similar sites found with APoc: 955
This union binding pocket(no: 1) in the query (biounit: 5e8j.bio2) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 1MID LAP None
2 1H5Q NAP None
3 1DCP HBI None
4 2JAH NDP 0.809717
5 3G2O SAM 1.00334
6 3SJU NDP 1.07527
7 3L9W AMP 1.28205
8 3L9W GSH 1.28205
9 1U8X NAD 1.28205
10 1FL2 FAD 1.29032
11 4Q9N NAI 1.34228
12 3JQ9 NAP 1.38889
13 3BMN NAP 1.38889
14 4RDH AMP 1.38889
15 3JQA NAP 1.38889
16 3JQ8 NAP 1.38889
17 4CM4 NAP 1.38889
18 4CMI NAP 1.38889
19 5K6A NAP 1.38889
20 4CLO NAP 1.38889
21 3JQB NAP 1.38889
22 4CM8 NAP 1.38889
23 5JDC NAP 1.38889
24 3JQ7 NAP 1.38889
25 5JDI NAP 1.38889
26 4CM9 NAP 1.38889
27 4CME NAP 1.38889
28 3JQF NAP 1.38889
29 5JCJ NAP 1.38889
30 3BMO NAP 1.38889
31 4CLR NAP 1.38889
32 3BMQ NAP 1.38889
33 3JQG NAP 1.38889
34 4RDI ATP 1.38889
35 2JL1 NAP 1.39373
36 4D79 ATP 1.44928
37 2PD4 NAD 1.45455
38 2PD4 DCN 1.45455
39 5THQ NDP 1.47059
40 4ITU NAI 1.48699
41 4ITU 1HS 1.48699
42 2WD7 NAP 1.49254
43 2VZ0 NAP 1.49254
44 2VZ0 D64 1.49254
45 2DTX BMA 1.51515
46 4V3I ASP LEU THR ARG PRO 1.55642
47 5J60 FAD 1.60256
48 3NYC IAR 1.60256
49 3NYC FAD 1.60256
50 5EOW FAD 1.60256
51 2O4C NAD 1.60256
52 4URF NAD 1.6129
53 3A25 SAM 1.66113
54 1XHL NDP 1.6835
55 3WXB NDP 1.79211
56 3DUW SAH 1.79372
57 1TZD ADP 1.81818
58 6F9Q NAD 1.83824
59 2DT5 NAD 1.89573
60 1YQZ FAD 1.92308
61 4X9M FAD 1.92308
62 2VVM FAD 1.92308
63 1LLU NAD 1.92308
64 5ZI2 NAD 1.92308
65 5ZI2 ADP 1.92308
66 1X7D NAD 1.92308
67 1X7D ORN 1.92308
68 5EJ2 NAD 1.94805
69 1E1M NAP 1.95652
70 1E1M FAD 1.95652
71 5OJL TXP 2.01342
72 1D7O TCL 2.0202
73 1D7O NAD 2.0202
74 2JAP NDP 2.02429
75 1PR9 NAP 2.04918
76 3D3W NAP 2.04918
77 3H8V ATP 2.05479
78 1ZQ9 SAM 2.10526
79 2BGM NAJ 2.15827
80 1AE1 NAP 2.1978
81 5T67 JHZ 2.24359
82 5T67 SAH 2.24359
83 2IVD FAD 2.24359
84 2PT9 2MH 2.24359
85 4ZCC NAI 2.24359
86 4ZCC FAD 2.24359
87 6AIN FAD 2.24359
88 4HXY NDP 2.24359
89 2RGO FAD 2.24359
90 2GN4 NDP 2.24359
91 5A1T OXM 2.24359
92 1RJW ETF 2.24359
93 2A8X FAD 2.24359
94 4M52 FAD 2.24359
95 2GN4 UD1 2.24359
96 2PT9 S4M 2.24359
97 3MAG SAH 2.28013
98 4OSP NAP 2.28137
99 2DKN NAI 2.35294
100 3MCT SAH 2.3569
101 1EDO NAP 2.45902
102 5KVA SAM 2.51799
103 5X62 SAH 2.5641
104 4PIO SAH 2.5641
105 4PIO AVI 2.5641
106 3TKY SAH 2.5641
107 6C5B SAH 2.5641
108 3NUG NAD 2.5641
109 2BRY FAD 2.5641
110 1GPE FAD 2.5641
111 1GY8 NAD 2.5641
112 5UR0 NAD 2.5641
113 3A27 SAM 2.57353
114 3OIG NAD 2.63158
115 1I1N SAH 2.65487
116 1ZEM NAD 2.67176
117 3OID NDP 2.71318
118 4BLW AMP 2.76817
119 4BLW SAH 2.76817
120 3KIF GDL 2.83019
121 4D42 W0I 2.83688
122 4D42 NAP 2.83688
123 3NDJ JHZ 2.88462
124 3NDJ SAH 2.88462
125 5TWB FAD 2.88462
126 3ICT FAD 2.88462
127 1PN0 IPH 2.88462
128 1PN0 FAD 2.88462
129 4BJZ FAD 2.88462
130 4BJZ P3A 2.88462
131 1KYZ FER 2.88462
132 3ICR FAD 2.88462
133 3ICS FAD 2.88462
134 1KYZ SAH 2.88462
135 1RYI GOA 2.88462
136 1RYI FAD 2.88462
137 2NPX FAD 2.88462
138 2NPX NAD 2.88462
139 3FXU TSU 2.88462
140 2E5V FAD 2.88462
141 5I7S E9P 2.89855
142 5I7S NAD 2.89855
143 2FZW NAD 2.94906
144 4YAC NAI 3.0303
145 4KWI 1TJ 3.04183
146 4KWI NAP 3.04183
147 4YAG NAI 3.11419
148 6ECW SAH 3.20513
149 6ECU SAH 3.20513
150 1FP1 SAH 3.20513
151 2YX1 SFG 3.20513
152 3LKZ SFG 3.20513
153 1D4D FAD 3.20513
154 5FUB SAH 3.20513
155 5EB4 FAD 3.20513
156 5X68 FAD 3.20513
157 5NUE NAD 3.20513
158 1J49 NAD 3.20513
159 1SB8 NAD 3.20513
160 1SB8 UD2 3.20513
161 2VTD LKM 3.20513
162 5NUF NAD 3.20513
163 3G89 SAM 3.21285
164 3I53 SAH 3.31325
165 3ELW SAM 3.33333
166 3ELW GP3 3.33333
167 5MGZ SAH 3.38983
168 4NEC SAH 3.40909
169 5M58 SAH 3.47826
170 5WUW NAP 3.48432
171 5YSS NAD 3.51562
172 2FR1 NDP 3.52564
173 1BXK NAD 3.52564
174 4O1M NAD 3.52564
175 5KKA 6V0 3.52564
176 2I7C AAT 3.53357
177 2Q28 ADP 3.5461
178 4ZA2 NAD 3.55731
179 3EVF SAH 3.61011
180 3EVF GTA 3.61011
181 2RH4 EMO 3.61011
182 4QED NAP 3.62903
183 3EVG SAH 3.63636
184 5N6C NAD 3.66667
185 3Q3C NAD 3.67893
186 2PX8 SAH 3.71747
187 5ULP KB1 3.73134
188 4NBT NAD 3.75
189 2JB2 PHE 3.84615
190 2JB2 FAD 3.84615
191 1ZGA SAH 3.84615
192 3CH6 NAP 3.84615
193 3CH6 311 3.84615
194 2AE2 PTO 3.84615
195 2AE2 NAP 3.84615
196 1LDN NAD 3.84615
197 1Q1R FAD 3.84615
198 4KGD TDP 3.84615
199 4KGD FAD 3.84615
200 1V8B NAD 3.84615
201 2Q1W NAD 3.84615
202 1W73 NAP 3.97351
203 1W8D NAP 3.97351
204 5JE8 NAD 3.97351
205 1T26 NAI 4.03727
206 1T26 GBD 4.03727
207 5DF1 58X 4.16667
208 5DF1 NAP 4.16667
209 2IZ1 ATR 4.16667
210 1XHC FAD 4.16667
211 4TQG NDP 4.16667
212 4D5G FAD 4.16667
213 4D5G TPP 4.16667
214 3KO8 NAD 4.16667
215 1E7S NAP 4.16667
216 5JWC FAD 4.16667
217 3LCV SAM 4.27046
218 4NBW NAD 4.28016
219 5LOG SAH 4.29185
220 4K26 NDP 4.34783
221 4K26 SFF 4.34783
222 3SJ7 NDP 4.36508
223 5ZW3 SAH 4.44444
224 3QWI CUE 4.44444
225 3QWI NAP 4.44444
226 2EG5 SAH 4.48718
227 6BQ6 TER 4.48718
228 2C5A GDC 4.48718
229 2C5A NAD 4.48718
230 1ZK7 FAD 4.48718
231 5GSN FAD 4.48718
232 5GSN NAP 4.48718
233 5ZBC FAD 4.48718
234 5GSN MMZ 4.48718
235 1D1T NAD 4.48718
236 3EYA FAD 4.48718
237 1VL8 NAP 4.49438
238 1Q7B NAP 4.5082
239 6C8R SAH 4.54545
240 6C8R EQV 4.54545
241 5BW4 SAM 4.54545
242 1G60 SAM 4.54545
243 5HJM MTA 4.54545
244 4CQM NAP 4.54545
245 2NXE SAM 4.54545
246 6GAR FAD 4.54545
247 3NTD FAD 4.54545
248 2B4Q NAP 4.54545
249 1G0N PHH 4.54545
250 1G0N NDP 4.54545
251 5IL1 SAM 4.54545
252 5K7U SAM 4.54545
253 5YJF 8WO 4.54545
254 5CG1 NAD BBN 4.54545
255 3NT6 FAD 4.54545
256 3NTA FAD 4.54545
257 1QG6 NAD 4.54545
258 1QG6 TCL 4.54545
259 1TL2 NDG 4.54545
260 5Y8L HUI 4.54545
261 5Y8L NAD 4.54545
262 5HJM HSL 4.54545
263 5YJF SAH 4.54545
264 3ORF NAD 4.54545
265 3PFG SAM 4.56274
266 3PFG TLO 4.56274
267 1YXM ADE 4.62046
268 1XKQ NDP 4.64286
269 3ICC NAP 4.70588
270 1JA9 NDP 4.74453
271 1PZG A3D 4.80769
272 1PGP 6PG 4.80769
273 1F8G NAD 4.80769
274 1X14 NAD 4.80769
275 2UYQ SAM 4.83871
276 4J7U YTZ 4.86111
277 4J7U NAP 4.86111
278 5XVH NAP 4.90196
279 1Z6Z NAP 4.96454
280 5L95 AMP 5
281 1OAA OAA 5.01931
282 6CI9 NAP 5.01931
283 1XSE NDP 5.08475
284 5MLR NAP 5.12821
285 5MLR GRQ 5.12821
286 3GF4 FAD 5.12821
287 3GF4 UPG 5.12821
288 6GAS FAD 5.12821
289 2A92 NAI 5.12821
290 1R6D DAU 5.12821
291 1R6D NAD 5.12821
292 1L7E NAI 5.12821
293 1FEC FAD 5.12821
294 5BSZ SAH 5.2
295 1IY8 NAD 5.24345
296 2VDV SAM 5.28455
297 1R18 SAH 5.28634
298 2HF9 GSP 5.30973
299 5GM1 SAH 5.38721
300 4D7E FAD 5.44872
301 2C7G FAD 5.44872
302 2C7G ODP 5.44872
303 4FZV SAM 5.44872
304 1V59 NAD 5.44872
305 4U8P UDP 5.44872
306 4U8P FDA 5.44872
307 4UCI SAM 5.44872
308 1GZ6 NAI 5.44872
309 1V59 FAD 5.44872
310 1ZBQ NAD 5.44872
311 3OJO NAD 5.44872
312 2R4J FAD 5.44872
313 2R4J 13P 5.44872
314 1SOW NAD 5.44872
315 1N7G NDP 5.44872
316 1E3I CXF 5.44872
317 5O42 9JW 5.47445
318 5O42 BGC 5.47445
319 5O42 NAD 5.47445
320 1VL0 NAI 5.47945
321 5Z2L NDP 5.71429
322 5MW4 5JU 5.76923
323 3QOX SAH 5.76923
324 1X1T NAD 5.76923
325 5B4T NAD 5.76923
326 5B4T 3HR 5.76923
327 4DSG FAD 5.76923
328 4DSG UDP 5.76923
329 3LAD FAD 5.76923
330 3OJF NDP 5.83658
331 3OJF IMJ 5.83658
332 1GEG NAD 5.85938
333 3H4V DVP 5.90278
334 3H4V NAP 5.90278
335 3C3Y SAH 5.90717
336 4YUW 4JU 5.92105
337 4YUW S4M 5.92105
338 1W6U NAP 5.96026
339 3FZG SAM 6
340 1F3L SAH 6.08974
341 3LU1 NAD 6.08974
342 1RM0 NAI 6.08974
343 3P2E SAH 6.22222
344 4PNE SAH 6.29139
345 1ZK4 NAP 6.3745
346 1ZK4 AC0 6.3745
347 5DNK SAH 6.41026
348 5K0A FAD 6.41026
349 4USQ FAD 6.41026
350 4CNK FAD 6.41026
351 9LDB NAD 6.41026
352 1DMR PGD 6.41026
353 2HJR APR 6.41026
354 9LDT NAD 6.41026
355 2A14 SAH 6.46388
356 3O03 NAP 6.52921
357 2XVM SAH 6.53266
358 5OJI ISN 6.53846
359 5OJI NAP 6.53846
360 5G3U FDA 6.73077
361 5G3U ITW 6.73077
362 5N0J FAD 6.73077
363 3AB1 FAD 6.73077
364 1U1I NAD 6.73077
365 2OBF SAH 6.81818
366 2OBF F83 6.81818
367 4AZW SAM 6.81818
368 3H2B SAH 6.81818
369 3GCZ SAM 6.81818
370 3GWZ SAH 6.81818
371 3GXO SAH 6.81818
372 4C3Y FAD 6.81818
373 4J36 FAD 6.81818
374 4C3Y ANB 6.81818
375 4J36 1HR 6.81818
376 3LZW NAP 6.81818
377 3LZW FAD 6.81818
378 5TUF FAD 6.81818
379 2VVL FAD 6.81818
380 2Y6Q FAD 6.81818
381 2Y6Q I7T 6.81818
382 3GD4 NAD 6.81818
383 3GD4 FAD 6.81818
384 2JHP SAH 6.81818
385 4BV6 FAD 6.81818
386 2VT3 ATP 6.81818
387 2Q0L FAD 6.81818
388 4L2I FAD 6.81818
389 2WET FAD 6.81818
390 2VHW NAI 6.81818
391 6MVU K4V 6.81818
392 5GT9 NAP 6.84411
393 4GKV NAD 6.84524
394 1SQL GUN 6.84932
395 3WDM ADN 6.89655
396 1N2X SAM 6.97674
397 4RF2 NAP 6.98529
398 4M73 SAH 7.05128
399 4M73 M72 7.05128
400 5F2K SAH 7.05128
401 5F2K OCA 7.05128
402 4KIB SAH 7.05128
403 3P9C SAH 7.05128
404 3RFV 15L 7.11611
405 3RFV NAI 7.11611
406 3ZV6 NAD 7.11744
407 3ZV6 4HB 7.11744
408 6DUB SAH 7.20721
409 5T2U NAP 7.25806
410 5MB4 NDG 7.37179
411 1LTH NAD 7.37179
412 2EJU SAH 7.69231
413 3AY6 NAI 7.80669
414 4FC7 COA 7.94224
415 4FC7 NAP 7.94224
416 1KPG SAH 8.01394
417 1Q0S SAH 8.10811
418 5FEU NAP 8.24742
419 3TKA SAM 8.33333
420 4MDH NAD 8.33333
421 5ME4 HP4 8.39416
422 2CFC NAD 8.4
423 2Q7V FAD 8.65385
424 5WKC FAD 8.65385
425 1T9D FAD 8.65385
426 2ZFU SAH 8.83721
427 3TN7 NJP 8.94942
428 3TLJ SAH 8.97436
429 4ONQ SFG 8.97436
430 2EFJ SAH 9.09091
431 5CUQ NSC 9.09091
432 5F8F SFG 9.09091
433 5U19 SAH 9.09091
434 5U19 827 9.09091
435 3LST SAH 9.09091
436 3HVJ 705 9.09091
437 4RVG SAM 9.09091
438 4RVG TYD 9.09091
439 4YMH SAH 9.09091
440 6ECT SAM 9.09091
441 5K4W THR 9.09091
442 5K4W NAI 9.09091
443 2V6G NAP 9.09091
444 1FK8 NAD 9.09091
445 1RSG FAD 9.09091
446 1YY5 FAD 9.09091
447 2XVF FAD 9.09091
448 4FWE FAD 9.09091
449 5JCA FAD 9.09091
450 5JCA NDP 9.09091
451 6FHO FAD 9.09091
452 1MO9 FAD 9.09091
453 1BDB NAD 9.09091
454 3V1U NAD 9.09091
455 3IHG FAD 9.09091
456 4JNA FAD 9.09091
457 1MO9 KPC 9.09091
458 3HB5 NAP 9.09091
459 1UXG NAD 9.09091
460 1UXG FUM 9.09091
461 4II2 ATP 9.09091
462 5XWV 8H6 9.09091
463 3ABI NAD 9.09091
464 5XWV NDP 9.09091
465 2Q2V NAD 9.09091
466 1MV8 NAD 9.09091
467 1MUU NAD 9.09091
468 2WYV NAD 9.09091
469 4GLL NAD 9.09091
470 3U31 NAD 9.09091
471 5ZZ6 NAD 9.09091
472 4LHD GLY 9.09091
473 5ZZ6 ADP 9.09091
474 4EIP FAD 9.09091
475 4E70 N7I 9.09091
476 3C6K SPD 9.18635
477 3C6K MTA 9.18635
478 3BXO SAM 9.20502
479 2O07 SPD 9.21053
480 2O07 MTA 9.21053
481 5OCM NAP 9.27835
482 5JAQ NAI 9.29487
483 5FFF 5XC 9.33852
484 5FFF NAP 9.33852
485 3LCC SAH 9.3617
486 3WMX NAD 9.61539
487 3WLE NAD 9.67742
488 3FPF TNA 9.73154
489 3FPF MTA 9.73154
490 1IM8 SAI 9.83607
491 5BJX UDP 9.9359
492 5BJX NAD 9.9359
493 4POO SAM 10
494 3LXD FAD 10.2564
495 2HMT NAI 10.4167
496 1L3I SAH 10.4167
497 2EWM NAD 10.4418
498 1SAY PYR 10.5263
499 4J56 FAD 10.5263
500 6H3O FAD 10.5769
501 1SC6 NAD 10.5769
502 1WY7 SAH 10.628
503 4TM3 FAD 10.8974
504 5KOX FAD 10.8974
505 5KOX RFP 10.8974
506 4MIG G3F 10.8974
507 5XLX SAH 10.9929
508 3RKR NAP 11.0687
509 1BC5 SAH 11.1524
510 4NTC FAD 11.2179
511 5Y77 FAD 11.2179
512 1I2B USQ 11.2179
513 1I2B NAD 11.2179
514 1I2B UPG 11.2179
515 4XUC 43G 11.3636
516 4XUC SAM 11.3636
517 4C4A SAH 11.3636
518 2P41 SAH 11.3636
519 5JJR SAH 11.3636
520 4AP3 FAD 11.3636
521 4AP3 NAP 11.3636
522 4Y30 49L 11.3636
523 4Y30 SAH 11.3636
524 2ZWA SAH 11.3636
525 2WSB NAD 11.3636
526 3BGD PM6 11.3636
527 5NMX FAD 11.3636
528 1WG8 SAM 11.3636
529 2GV8 FAD 11.3636
530 1Y8Q ATP 11.3636
531 3CGD FAD 11.3636
532 2GVC FAD 11.3636
533 1VQW FAD 11.3636
534 3CGD COA 11.3636
535 5BVA FAD 11.3636
536 4Y9D NAI 11.3636
537 3CGD NAD 11.3636
538 3CGB FAD 11.3636
539 5BUK FAD 11.3636
540 5U8U FAD 11.3636
541 3NJ4 AFX 11.3636
542 3NJ4 NAD 11.3636
543 1EFV FAD 11.3636
544 1EFV AMP 11.3636
545 3FPZ AHZ 11.3636
546 6F97 FAD 11.3636
547 4NBU NAI 11.3636
548 5HXI 5HN 11.3636
549 5HXI FAD 11.3636
550 4PLT OXM 11.3636
551 5OCQ CIT 11.3636
552 1KNR FAD 11.3636
553 3GMB FAD 11.3636
554 2WK1 SAH 11.3636
555 6F7L FAD 11.3636
556 2NVK FAD 11.3636
557 4XQC 13D 11.3636
558 4XQC NAD 11.3636
559 4PLT NAI 11.3636
560 1WVG APR 11.3636
561 3BGD SAH 11.3636
562 6FP4 E1T 11.3636
563 6FP4 FAD 11.3636
564 4YKG FAD 11.3636
565 4YKG NAD 11.3636
566 3VZS CAA 11.3636
567 5L53 NAP 11.3636
568 3VZS NAP 11.3636
569 5L4S 6KX 11.3636
570 5L4S NAP 11.3636
571 6F5Z SAH 11.4754
572 1OC2 TDX 11.5385
573 1OC2 NAD 11.5385
574 2Q46 NAP 11.8577
575 2YY7 NAD 11.859
576 3A4T SFG 12.0438
577 4FN4 NAD 12.2047
578 3DXY SAM 12.3853
579 4MOP 2H5 12.5
580 1I9G SAM 12.5
581 3EGI ADP 12.6214
582 1VM6 NAD 12.7193
583 5GWT SIN 12.9496
584 5GWT NAD 12.9496
585 5MPT SAH 13.141
586 3A28 NAD 13.1783
587 2FK8 SAM 13.4615
588 3A4V NAD 13.4615
589 3A4V PYR 13.4615
590 1JQ3 AAT 13.5135
591 3GRU AMP 13.6364
592 2XYQ SAH 13.6364
593 4B63 ORN 13.6364
594 4B63 NAP 13.6364
595 4B63 FAD 13.6364
596 2BZG SAH 13.6364
597 5KMS NAD 13.6364
598 5I39 FAD 13.6364
599 1X87 NAD 13.6364
600 3KLJ FAD 13.6364
601 5JCM FAD 13.6364
602 5JCM ISD 13.6364
603 5JCM NAD 13.6364
604 5N5D SAM 13.6364
605 1RLZ NAD 13.6364
606 2B9W FAD 13.6364
607 4EMI NAD 13.6364
608 4EMI FAD 13.6364
609 4OM8 NAD 13.6364
610 4JDR FAD 13.6364
611 5KMS FAD 13.6364
612 3RJ5 NAD 13.6364
613 4YSX FAD 13.6364
614 5Y1G NAD 13.6364
615 5Y1G AKB 13.6364
616 1V35 NAI 13.6364
617 2HNK SAH 13.6364
618 1EK6 NAI 13.6364
619 1G8K MGD 13.6364
620 1GV0 NAD 13.6364
621 1F8F NAD 13.6364
622 1GUZ NAD 13.6364
623 4O0L NDP 13.6364
624 1EK6 UPG 13.6364
625 1OMO NAD 13.6364
626 1Q19 SSC 13.6364
627 2IVF MGD 13.6364
628 4G5H NAP 13.6364
629 4G5H UD7 13.6364
630 1UP7 NAD 13.6364
631 1GR0 NAD 13.6364
632 3GEG NAD 13.7652
633 1HYH NAD 13.9159
634 1U2Z SAH 14.7436
635 5Z75 NAD 15.3846
636 3OU2 SAH 15.5963
637 4KRG SAH 15.9091
638 1JQD SAH 15.9091
639 2AOT SAH 15.9091
640 2WA2 SAM 15.9091
641 2PWY SAH 15.9091
642 3X0D SAH 15.9091
643 4M37 SAH 15.9091
644 3QJ4 FAD 15.9091
645 1JQD HSM 15.9091
646 2JJQ SAH 15.9091
647 1XDS SAM 15.9091
648 2CDU FAD 15.9091
649 4RPL 3UC 15.9091
650 4RPL FAD 15.9091
651 4X7Y SAH 15.9091
652 3S1S SAH 15.9091
653 2Z3Y F2N 15.9091
654 5BRT FAD 15.9091
655 5BRT CH9 15.9091
656 2GDZ NAD 15.9091
657 1QZZ SAM 15.9091
658 5MBX FAD 15.9091
659 5MBX SP5 15.9091
660 5J5Z FAD 15.9091
661 2GAG NAD 15.9091
662 3RNM FAD 15.9091
663 4USR FAD 15.9091
664 2RAB NAD 15.9091
665 3GDN HBX 15.9091
666 3GDN FAD 15.9091
667 1RP0 AHZ 15.9091
668 2F5Z FAD 15.9091
669 4DMG SAM 15.9091
670 2RAB FAD 15.9091
671 2GAG FOA 15.9091
672 2GAG FAD 15.9091
673 5E72 SAM 15.9091
674 3AFN NAP 15.9091
675 5W7R 9Z7 15.9091
676 2WPF WPF 15.9091
677 2WPF FAD 15.9091
678 5UAO FAD 15.9091
679 5W7R SAH 15.9091
680 5GWX SAM 15.9091
681 5GWX SAR 15.9091
682 1KEW NAD 15.9091
683 3CTY FAD 15.9091
684 3VPH OXM 15.9091
685 1KEW TYD 15.9091
686 3QFA FAD 15.9091
687 1UAY ADN 15.9091
688 1YC5 NCA 15.9091
689 1DL5 SAH 15.9091
690 1YBH FAD 15.9091
691 1JNR FAD 15.9091
692 2CDU ADP 15.9091
693 4BUZ NAD 15.9091
694 4BUZ OCZ 15.9091
695 4BUZ OAD 15.9091
696 4ONT SIA GAL BGC 15.9091
697 5Z21 NAI 15.9091
698 6C4N NAP 15.9091
699 3VPH NAD 15.9091
700 6GKV SAH 16.0256
701 3GDH SAH 16.1826
702 5W7K SAH 16.3462
703 1QAN SAH 16.3934
704 1XTP SAI 16.5354
705 3JWH SAH 18.1818
706 4QTU SAM 18.1818
707 3VC1 SAH 18.1818
708 3VC1 GST 18.1818
709 3MB5 SAM 18.1818
710 1TPY SAH 18.1818
711 5YJI SAH 18.1818
712 5YJI 8WO 18.1818
713 3T7S SAM 18.1818
714 4DCM SAM 18.1818
715 4N49 SAM 18.1818
716 1REO FAD 18.1818
717 6EL3 NAP 18.1818
718 5TS5 FAD 18.1818
719 2YG3 FAD 18.1818
720 4MO2 FDA 18.1818
721 4MO2 FAD 18.1818
722 3HDY GDU 18.1818
723 3HDY FDA 18.1818
724 1E6E FAD 18.1818
725 3HDY FAD 18.1818
726 5E1M PRO PRO LYS ARG ILE ALA 18.1818
727 5E1M SAH 18.1818
728 4K5S FAD 18.1818
729 4K5S PM0 18.1818
730 1COY FAD 18.1818
731 4Z24 FAD 18.1818
732 4TXI FAD 18.1818
733 1H9A NAP 18.1818
734 4J4H 1J1 18.1818
735 4J4H NAI 18.1818
736 5UFN SAH 18.1818
737 1LSS NAD 18.1818
738 3Q9T FAY 18.1818
739 1O97 FAD 18.1818
740 4JK3 NAD 18.1818
741 1O97 AMP 18.1818
742 3QVP FAD 18.1818
743 1COY AND 18.1818
744 4PLG OXM 18.1818
745 4PLG NAI 18.1818
746 3WV8 ATP 18.1818
747 2OOR NAD 18.1818
748 2UXR ICT 18.1818
749 1NV8 MEQ 18.1818
750 3M6W SAM 18.1818
751 1NM5 NAD 18.1818
752 1NV8 SAM 18.1818
753 2OOR TXP 18.1818
754 1O5O U5P 18.1818
755 5OVL NAP 18.1818
756 3GU3 SAH 18.3099
757 1JG3 ADN 18.5897
758 2C31 TZD 18.5897
759 2C31 ADP 18.5897
760 1KPH SAH 19.1638
761 5JE0 AZ8 19.4332
762 5JE0 SAH 19.4332
763 2PXX SAH 19.5349
764 3ZLR X0B 19.6203
765 1MXH NAP 19.9275
766 1MXH DHF 19.9275
767 5WP5 SAH 20.4545
768 5DM1 SAH 20.4545
769 5DM1 5D7 20.4545
770 3FRH SAH 20.4545
771 5YF1 SFG 20.4545
772 5YF1 8V0 20.4545
773 5THY SAH 20.4545
774 2BD0 NAP 20.4545
775 3VYW SAM 20.4545
776 1L1E SAH 20.4545
777 1NW5 SAM 20.4545
778 3Q87 SAM 20.4545
779 1QO8 FAD 20.4545
780 1I8T FAD 20.4545
781 5THZ SAH 20.4545
782 3AYI FAD 20.4545
783 3AYI HCI 20.4545
784 2XVE FAD 20.4545
785 4IV9 FAD 20.4545
786 2ZIF SAM 20.4545
787 5ZYN FAD 20.4545
788 1ELI PYC 20.4545
789 2QA1 FAD 20.4545
790 4J1Q NDP 20.4545
791 3UOY NAP 20.4545
792 3UOY FAD 20.4545
793 3K7M FAD 20.4545
794 3SSO SAH 20.4545
795 1GTE FAD 20.4545
796 3T31 DCQ 20.4545
797 3T31 FAD 20.4545
798 6F3M NAD 20.4545
799 5EZ7 FAD 20.4545
800 2GMH FAD 20.4545
801 5ODQ FAD 20.4545
802 5V8E CIT 20.4545
803 6DNT NAD 20.4545
804 1O5I NAD 20.4545
805 1H2B NAJ 20.4545
806 3OFK SAH 20.8333
807 5FA8 SAM 21.118
808 4EMJ FAD 22.4299
809 1RJD SAM 22.7273
810 2IID FAD 22.7273
811 2IID PHE 22.7273
812 5JGL SAM 22.7273
813 3DMH SAM 22.7273
814 5HSA FAS 22.7273
815 5NA1 FAD 22.7273
816 1Q9I FAD 22.7273
817 1Q9I TEO 22.7273
818 2YVF FAD 22.7273
819 2YVF NAD 22.7273
820 5M67 ADE 22.7273
821 2ZJ1 ARJ 22.7273
822 1GET NAP 22.7273
823 1GET FAD 22.7273
824 5M67 NAD 22.7273
825 5M67 3D1 22.7273
826 2CUL FAD 22.7273
827 2YVJ FAD 22.7273
828 1E6W NAD 22.7273
829 2ZJ1 NAD 22.7273
830 3DMH GMP 22.7273
831 1E3W NAD 22.7273
832 5FWA J7C 22.7273
833 3B1F NAD 22.7273
834 3AXB FAD 22.7273
835 3AXB PRO 22.7273
836 5YEC ATP 22.7273
837 2A2C ADP 22.7273
838 2A2C NG1 22.7273
839 3FWN ATR 22.7273
840 4M38 SAH 23.8095
841 4IWN GEK 24.4541
842 5W7M SAH 25
843 3PT9 SAH 25
844 5ICE 2H4 25
845 5ICE SAH 25
846 6ARJ BW4 25
847 5DX8 SFG 25
848 6ARJ SAH 25
849 5EEH SAH 25
850 5EEH P9P 25
851 3FUU ADN 25
852 3S5W FAD 25
853 4EUE NAI 25
854 3CBG SAH 25
855 1UWK URO 25
856 1UWK NAD 25
857 4GUS FAD 25
858 3AD8 NAD 25
859 4GUT FAD 25
860 4HSU FAD 25
861 5TTJ FAD 25
862 4OPC PGT 25
863 4OPC FDA 25
864 2AG5 NAD 25
865 5XNC MTA 25
866 5DXA SFG 25
867 3AD8 FAD 25
868 3AD8 PYC 25
869 5DX1 SFG 25
870 1U7T TDT 25
871 5J7X FAD 25
872 5DX0 SFG 25
873 5DWQ SFG 25
874 1ORR NAD 25
875 1U7T NAD 25
876 4OIV XX9 25
877 1VE3 SAM 25.5507
878 1EJ0 SAM 26.6667
879 5DLY SAH 27.2727
880 5DLY 5D7 27.2727
881 3VSE SAH 27.2727
882 1G55 SAH 27.2727
883 4LWP SAH 27.2727
884 3X0V FAD 27.2727
885 5WGR FAD 27.2727
886 1XCL SAH 27.2727
887 2DPM SAM 27.2727
888 1XG5 NAP 27.2727
889 4YRY FAD 27.2727
890 1LVL NAD 27.2727
891 1P1C SAH 27.2727
892 2AQJ TRP 27.2727
893 2AQJ FAD 27.2727
894 1LVL FAD 27.2727
895 2ZXI FAD 27.2727
896 6B92 SAH 27.2727
897 6GFK SAH 27.2727
898 4GQB 0XU 29.5455
899 4X60 SFG 29.5455
900 4X60 3XV 29.5455
901 3U4C NDP 29.5455
902 5FA5 MTA 29.5455
903 6ER9 NAP 29.5455
904 6ER9 FAD 29.5455
905 3OND NAD 29.5455
906 3OND ADN 29.5455
907 3ML1 MGD 29.5455
908 1RKX NAD 29.5455
909 2NYA MGD 29.5455
910 2G5C NAD 29.5455
911 3GGO NAI 29.5455
912 5FTW SAH 29.6875
913 4R6W PC 31.8182
914 4R6W SAH 31.8182
915 3UCL FAD 31.8182
916 3UCL CYH 31.8182
917 3UCL NAP 31.8182
918 1E5Q NDP 31.8182
919 3G5S FAD 31.8182
920 1P3D UMA 31.8182
921 3EYK EYK 31.8182
922 1P31 EPU 31.8182
923 1NNU NAD 33.3333
924 1NNU TCT 33.3333
925 4A6D SAM 34.0909
926 1FP2 SAH 34.0909
927 3MQ2 SAH 34.0909
928 1FP2 HMO 34.0909
929 3E1T FAD 34.0909
930 5YB7 ORN 34.0909
931 5YB7 FAD 34.0909
932 3QV1 NAD 34.0909
933 5WP4 SAH 36.3636
934 6FDF SAH 36.3636
935 1PS9 FAD 36.3636
936 5FJN BE2 36.3636
937 5FJN FAD 36.3636
938 1PS9 NAP 36.3636
939 5KOK SAH 38.6364
940 1SQF SAM 38.6364
941 4OBW SAM 38.6364
942 5VN0 FAD 38.6364
943 5VN0 NAI 38.6364
944 1H82 FAD 38.6364
945 1H82 GZZ 38.6364
946 5KOK S9T 38.6364
947 5KOK R9T 38.6364
948 2IV2 MGD 38.6364
949 1Z45 NAD 38.6364
950 5ERG SAM 40.9091
951 2GCE SFC 40.9091
952 3O7W SAM 43.1818
953 4KRI SAH 43.1818
954 2DKH FAD 43.1818
955 2DKH 3HB 43.1818
Pocket No.: 2; Query (leader) PDB : 5E8J; Ligand: SAH; Similar sites found with APoc: 24
This union binding pocket(no: 2) in the query (biounit: 5e8j.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 5OC1 FAD 1.92308
2 1NFQ NAI 2.69231
3 4NTD FAD 2.88462
4 1EZ4 NAD 3.84615
5 5U5N NAD 6.09319
6 1JJV ATP 6.79612
7 4ZVV GN0 6.81818
8 4ZVV NAD 6.81818
9 1BZL FAD 7.69231
10 1A27 NAP 9.09091
11 5NMX NAP 11.3636
12 5AHN IMP 11.3636
13 3GFB NAD 11.3636
14 2DFV NAD 11.3636
15 3OZ2 FAD 15.9091
16 5OJ7 AR6 15.9091
17 1NM5 NAP 18.1818
18 5TUK FAD 20.4545
19 2PK3 A2R 20.4545
20 5A3B APR 20.4545
21 1KNM LAT 25
22 2HQM FAD 31.8182
23 4HA6 FAD 34.0909
24 2RGJ FAD 40.9091
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