Receptor
PDB id Resolution Class Description Source Keywords
5E9W 2.28 Å EC: 2.1.1.56 CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASE O LIMITED PROTEOLYSIS HOMO SAPIENS MRNA CAPPING TRANSFERASE
Ref.: MOLECULAR BASIS OF RNA GUANINE-7 METHYLTRANSFERASE ACTIVATION BY RAM. NUCLEIC ACIDS RES. V. 44 10423 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAH B:501;
A:500;
C:501;
D:501;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
384.411 C14 H20 N6 O5 S c1nc(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5E9W 2.28 Å EC: 2.1.1.56 CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASE O LIMITED PROTEOLYSIS HOMO SAPIENS MRNA CAPPING TRANSFERASE
Ref.: MOLECULAR BASIS OF RNA GUANINE-7 METHYLTRANSFERASE ACTIVATION BY RAM. NUCLEIC ACIDS RES. V. 44 10423 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5E9W - SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5E9W - SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5E9W - SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 197
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 SXZ 0.692308 0.916667
6 DSH 0.692308 0.914286
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 RAB 0.573333 0.84058
19 ADN 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SSA 0.536842 0.712644
28 SMM 0.536842 0.88
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 AMP 0.529412 0.763158
36 A 0.529412 0.763158
37 5CA 0.525773 0.712644
38 ME8 0.524752 0.8125
39 M2T 0.52439 0.821918
40 6RE 0.523256 0.824324
41 GJV 0.522727 0.813333
42 AAT 0.515789 0.863014
43 LSS 0.515152 0.696629
44 KAA 0.514852 0.727273
45 J7C 0.511364 0.835616
46 A5A 0.510417 0.697674
47 SON 0.505495 0.805195
48 SRP 0.505155 0.805195
49 5AL 0.5 0.779221
50 VMS 0.5 0.681818
51 KH3 0.5 0.866667
52 ADX 0.5 0.694118
53 CA0 0.5 0.769231
54 AMP MG 0.5 0.74359
55 AMO 0.5 0.805195
56 54H 0.5 0.681818
57 AHX 0.49505 0.753086
58 TSB 0.494949 0.689655
59 53H 0.494949 0.674157
60 G5A 0.494737 0.712644
61 A2D 0.494382 0.74359
62 ABM 0.494382 0.74359
63 ZAS 0.494253 0.808219
64 A6D 0.490196 0.759494
65 8QN 0.49 0.779221
66 GEK 0.49 0.956522
67 GAP 0.489583 0.769231
68 A3S 0.48913 0.884058
69 AN2 0.48913 0.734177
70 S4M 0.488889 0.831169
71 SRA 0.488636 0.746835
72 LAD 0.485437 0.810127
73 52H 0.484848 0.674157
74 A12 0.483516 0.759494
75 BA3 0.483516 0.74359
76 AP2 0.483516 0.759494
77 AOC 0.483146 0.842857
78 NEC 0.483146 0.788732
79 Y3J 0.481481 0.768116
80 NVA LMS 0.480392 0.696629
81 VRT 0.479167 0.861111
82 50T 0.478723 0.734177
83 5AS 0.478261 0.655556
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 AP5 0.478261 0.74359
87 A3N 0.477778 0.830986
88 YSA 0.476636 0.712644
89 XAH 0.476636 0.768293
90 0XU 0.473684 0.897059
91 WAQ 0.471154 0.807692
92 NSS 0.470588 0.712644
93 5AD 0.468354 0.791045
94 ADP MG 0.468085 0.734177
95 AU1 0.468085 0.725
96 M33 0.468085 0.734177
97 MAO 0.467391 0.797468
98 TXA 0.466667 0.759494
99 A3G 0.466667 0.871429
100 NB8 0.466667 0.775
101 3AM 0.465909 0.727273
102 DAL AMP 0.465347 0.779221
103 ATP 0.463158 0.74359
104 ADP BEF 0.463158 0.716049
105 A3T 0.463158 0.842857
106 BEF ADP 0.463158 0.716049
107 ACP 0.463158 0.746835
108 7D7 0.4625 0.785714
109 LEU LMS 0.461538 0.677778
110 APC 0.458333 0.759494
111 AQP 0.458333 0.74359
112 APR 0.458333 0.766234
113 PRX 0.458333 0.746835
114 AR6 0.458333 0.766234
115 5FA 0.458333 0.74359
116 IOT 0.456897 0.761905
117 4AD 0.456311 0.794872
118 PAJ 0.456311 0.722892
119 WSA 0.45614 0.72093
120 FA5 0.453704 0.805195
121 YAP 0.453704 0.794872
122 RBY 0.453608 0.782051
123 ADV 0.453608 0.782051
124 ADP PO3 0.453608 0.763158
125 AD9 0.453608 0.725
126 SAP 0.453608 0.728395
127 AGS 0.453608 0.728395
128 PTJ 0.45283 0.731707
129 MHZ 0.452632 0.797468
130 00A 0.451923 0.740741
131 A3P 0.451613 0.74026
132 YLP 0.451327 0.771084
133 7MD 0.45045 0.768293
134 ALF ADP 0.45 0.707317
135 ADP ALF 0.45 0.707317
136 ATP MG 0.44898 0.734177
137 2VA 0.447917 0.819444
138 OOB 0.446602 0.779221
139 ANP 0.444444 0.725
140 ACQ 0.444444 0.746835
141 TAT 0.444444 0.7375
142 P5A 0.443396 0.719101
143 7D5 0.443182 0.708861
144 ARG AMP 0.442478 0.759036
145 A1R 0.442308 0.7625
146 YLC 0.439655 0.790123
147 2AM 0.438202 0.717949
148 DLL 0.438095 0.779221
149 A22 0.436893 0.734177
150 D3Y 0.436893 0.859155
151 TYR AMP 0.436364 0.782051
152 ATF 0.435644 0.716049
153 MYR AMP 0.435185 0.746988
154 SO8 0.434343 0.808219
155 3UK 0.433962 0.769231
156 OAD 0.433962 0.769231
157 TAD 0.433628 0.765432
158 25A 0.432692 0.74359
159 ANP MG 0.431373 0.707317
160 VO4 ADP 0.431373 0.734177
161 ADP VO4 0.431373 0.734177
162 9SN 0.431193 0.731707
163 TYM 0.431034 0.805195
164 PR8 0.429907 0.8
165 ADQ 0.428571 0.746835
166 YLB 0.42735 0.771084
167 3OD 0.425926 0.769231
168 FYA 0.425926 0.779221
169 1ZZ 0.425926 0.746988
170 PPS 0.425743 0.674419
171 NVA 2AD 0.424242 0.808219
172 MAP 0.423077 0.707317
173 A2P 0.421053 0.727273
174 4YB 0.421053 0.735632
175 ADP BMA 0.420561 0.746835
176 5SV 0.419048 0.731707
177 3NZ 0.416667 0.824324
178 YLA 0.416667 0.771084
179 48N 0.413793 0.753086
180 LPA AMP 0.413793 0.768293
181 AYB 0.413223 0.761905
182 QQY 0.413043 0.696203
183 ACK 0.413043 0.710526
184 JB6 0.412844 0.7625
185 BIS 0.412844 0.719512
186 PAP 0.41 0.730769
187 OVE 0.408602 0.7125
188 4UV 0.40708 0.75
189 AMP DBH 0.40708 0.746835
190 3AD 0.406977 0.852941
191 AF3 ADP 3PG 0.40678 0.743902
192 OMR 0.40678 0.738095
193 LAQ 0.405172 0.768293
194 A A 0.40367 0.74359
195 7C5 0.403509 0.789474
196 7MC 0.403361 0.75
197 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5E9W; Ligand: SAH; Similar sites found: 239
This union binding pocket(no: 1) in the query (biounit: 5e9w.bio4) has 17 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1LSS NAD 0.0001064 0.43986 None
2 3G2O SAM 0.00000439 0.50816 1.00334
3 4DMG SAM 0.0004896 0.45957 1.01781
4 3NJ4 AFX 0.01149 0.46708 1.28205
5 3NJ4 NAD 0.02076 0.45251 1.28205
6 4Q9N NAI 0.02017 0.40911 1.34228
7 5K6A NAP 0.00864 0.42618 1.38889
8 4RDH AMP 0.003759 0.40661 1.38889
9 5THQ NDP 0.003677 0.4445 1.47059
10 4V3I ASP LEU THR ARG PRO 0.01243 0.40685 1.55642
11 2B9W FAD 0.009197 0.44743 1.60256
12 1UP7 NAD 0.006905 0.42545 1.60256
13 2O4C NAD 0.02651 0.40317 1.60256
14 3A25 SAM 0.0002642 0.43401 1.66113
15 3O7W SAM 0.0000000368 0.62976 1.70068
16 3DUW SAH 0.0002035 0.43429 1.79372
17 1N4W FAD 0.001405 0.48055 1.92308
18 1SQF SAM 0.00006924 0.46052 1.92308
19 1GET NAP 0.01302 0.44648 1.92308
20 1GET FAD 0.01238 0.44648 1.92308
21 2UYQ SAM 0.00001809 0.5523 1.93548
22 1PR9 NAP 0.00009184 0.52816 2.04918
23 3H8V ATP 0.001082 0.41866 2.05479
24 1ZQ9 SAM 0.00007806 0.45797 2.10526
25 1AE1 NAP 0.00811 0.43121 2.1978
26 4KRG SAH 0.00000004444 0.59601 2.24359
27 4LWP SAH 0.00001779 0.48241 2.24359
28 3NTD FAD 0.002648 0.46129 2.24359
29 1G55 SAH 0.000177 0.43855 2.24359
30 2PT9 S4M 0.0002117 0.4025 2.24359
31 1G60 SAM 0.00004041 0.45791 2.30769
32 3BGD SAH 0.0003027 0.41418 2.30769
33 3FRH SAH 0.000006344 0.56821 2.37154
34 5KVA SAM 0.000748 0.40466 2.51799
35 3TKY SAH 0.00001111 0.54934 2.5641
36 5X62 SAH 0.000001401 0.53699 2.5641
37 3GWZ SAH 0.00002153 0.51066 2.5641
38 4DCM SAM 0.0000128 0.50679 2.5641
39 5E72 SAM 0.0001361 0.50225 2.5641
40 3GXO SAH 0.00006143 0.48189 2.5641
41 4N49 SAM 0.0001728 0.43441 2.5641
42 4E70 N7I 0.00005847 0.40145 2.5641
43 3A27 SAM 0.0002377 0.43811 2.57353
44 1I1N SAH 0.00009327 0.40284 2.65487
45 1NFQ NAI 0.01609 0.41518 2.69231
46 2NXE SAM 0.0001935 0.44157 2.75591
47 5IL1 SAM 0.002197 0.40222 2.83019
48 4D42 W0I 0.02542 0.42054 2.83688
49 4D42 NAP 0.02542 0.42054 2.83688
50 4Y2H SAH 0.0002089 0.51833 2.88462
51 4Y2H 49K 0.0005192 0.49828 2.88462
52 1KYZ SAH 0.0000879 0.46641 2.88462
53 1PS9 FAD 0.002458 0.4661 2.88462
54 4GLL NAD 0.02113 0.40925 2.88462
55 5BW4 SAM 0.000007927 0.50794 2.99625
56 1FK8 NAD 0.0002722 0.40187 3.11284
57 1WG8 SAM 0.0007778 0.46973 3.15789
58 5XVK SAH 0.000006006 0.46628 3.16901
59 5XVQ SAH 0.000006189 0.46433 3.16901
60 2YX1 SFG 0.00002079 0.51019 3.20513
61 1FP1 SAH 0.0003518 0.50441 3.20513
62 2CDU FAD 0.0004877 0.49601 3.20513
63 1QO8 FAD 0.0006902 0.49533 3.20513
64 5JJR SAH 0.00001503 0.48476 3.20513
65 3LKZ SFG 0.00001366 0.47654 3.20513
66 3S1S SAH 0.000003418 0.46626 3.20513
67 5EB4 FAD 0.003311 0.45848 3.20513
68 5UAO FAD 0.008006 0.43694 3.20513
69 2CDU ADP 0.005845 0.41679 3.20513
70 1Y8Q ATP 0.0004347 0.40217 3.20513
71 3G89 SAM 0.0000004586 0.58286 3.21285
72 2P41 SAH 0.00004256 0.46774 3.27869
73 3I53 SAH 0.0001244 0.43795 3.31325
74 2ZIF SAM 0.0002707 0.42948 3.367
75 5MGZ SAH 0.000005328 0.4949 3.38983
76 3GRU AMP 0.00005354 0.43534 3.38983
77 4NEC SAH 0.00000004314 0.61079 3.40909
78 2BZG SAH 0.0003385 0.43093 3.44828
79 5M58 SAH 0.000004652 0.49668 3.47826
80 5F8F SFG 0.0000007848 0.55755 3.52564
81 3X0D SAH 0.00002755 0.4697 3.52564
82 3GCZ SAM 0.00001684 0.48287 3.5461
83 2WA2 SAM 0.0000102 0.54571 3.62319
84 3EVG SAH 0.00003134 0.47336 3.63636
85 2AG5 NAD 0.002994 0.44891 3.65854
86 2PX8 SAH 0.0000262 0.4734 3.71747
87 5ULP KB1 0.000004684 0.4603 3.73134
88 5CUQ NSC 0.000008423 0.5781 3.74532
89 2HNK SAH 0.000819 0.41164 3.76569
90 2AOT SAH 0.00000202 0.54069 3.76712
91 1JQD SAH 0.000006806 0.42433 3.76712
92 1JQD HSM 0.00008296 0.40803 3.76712
93 5KOK SAH 0.00000009479 0.55299 3.84615
94 5HJM MTA 0.00007973 0.45002 3.84615
95 5KOK S9T 0.0000003641 0.42904 3.84615
96 5KOK R9T 0.0000007258 0.42493 3.84615
97 1LDN NAD 0.009716 0.4249 3.84615
98 5HJM HSL 0.007672 0.4017 3.84615
99 5GWX SAM 0.00004271 0.42061 3.87324
100 5GWX SAR 0.00004271 0.42061 3.87324
101 3AFN NAP 0.005453 0.43982 3.87597
102 3H2B SAH 0.000009336 0.48117 3.94089
103 5N5D SAM 0.0001505 0.49584 3.9823
104 4KRI SAH 0.0000002821 0.52442 4.16667
105 3LCV SAM 0.00005498 0.43762 4.27046
106 5LOG SAH 0.0002451 0.43536 4.29185
107 2EG5 SAH 0.0000001273 0.60678 4.48718
108 2EFJ SAH 0.0002182 0.51737 4.48718
109 1P1C SAH 0.000266 0.41452 4.52261
110 1YXM ADE 0.002958 0.44132 4.62046
111 1DL5 SAH 0.0001059 0.4085 4.80769
112 1Z6Z NAP 0.0004148 0.4912 4.96454
113 5L95 AMP 0.000447 0.4259 5
114 2WSB NAD 0.0004263 0.50379 5.11811
115 4AZT SAM 0.000004038 0.50819 5.12821
116 4AZW SAM 0.000008892 0.48712 5.12821
117 3UCL FAD 0.002392 0.48405 5.12821
118 3UCL NAP 0.002605 0.48405 5.12821
119 3UCL CYH 0.002392 0.48405 5.12821
120 1ELI PYC 0.001369 0.47579 5.12821
121 4C4A SAH 0.00002829 0.468 5.12821
122 4J36 FAD 0.002135 0.46012 5.12821
123 4J36 1HR 0.003963 0.45744 5.12821
124 3FUU ADN 0.000004698 0.48995 5.16605
125 2VDV SAM 0.000001641 0.55891 5.28455
126 1R18 SAH 0.00007331 0.43739 5.28634
127 5GM1 SAH 0.0000009729 0.49265 5.38721
128 1V59 NAD 0.001181 0.44205 5.44872
129 4FZV SAM 0.0001059 0.43917 5.44872
130 4UCI SAM 0.0002969 0.43046 5.44872
131 1VL0 NAI 0.002567 0.44632 5.47945
132 3VYW SAM 0.0001357 0.43903 5.51948
133 3QOX SAH 0.00009386 0.51204 5.76923
134 2ZWA SAH 0.000002727 0.48669 5.76923
135 2F5Z FAD 0.00252 0.46753 5.76923
136 3PT9 SAH 0.00008848 0.45398 5.76923
137 2JHP SAH 0.001357 0.42052 5.76923
138 3C3Y SAH 0.000336 0.42923 5.90717
139 3FZG SAM 0.0001459 0.46329 6
140 1F3L SAH 0.0001036 0.43352 6.08974
141 3P2E SAH 0.00003187 0.45891 6.22222
142 4PNE SAH 0.0000007358 0.497 6.29139
143 5DNK SAH 0.000004007 0.54568 6.41026
144 4CNK FAD 0.00296 0.45885 6.41026
145 5DXA SFG 0.00004264 0.4355 6.41026
146 5DX8 SFG 0.00005543 0.43213 6.41026
147 5DWQ SFG 0.00007398 0.4239 6.41026
148 5DX0 SFG 0.00005171 0.42113 6.41026
149 5DX1 SFG 0.00006189 0.41977 6.41026
150 2A14 SAH 0.00004437 0.44459 6.46388
151 2VT3 ATP 0.001606 0.43594 6.51163
152 2XVM SAH 0.000000005712 0.66576 6.53266
153 2PWY SAH 0.004444 0.46015 6.58915
154 3Q9T FAY 0.004459 0.44877 6.73077
155 1JJV ATP 0.01462 0.40527 6.79612
156 3EGV SAH 0.0001628 0.45193 6.80272
157 1NV8 MEQ 0.00004712 0.40395 7.04225
158 1NV8 SAM 0.00005503 0.40267 7.04225
159 4KIB SAH 0.000001154 0.58994 7.05128
160 4M73 SAH 0.0000004545 0.42482 7.05128
161 4M73 M72 0.000000962 0.41455 7.05128
162 5F2K SAH 0.00001451 0.40138 7.05128
163 5F2K OCA 0.00001451 0.40138 7.05128
164 1RJD SAM 0.000000461 0.52042 7.37179
165 3GDN HBX 0.005102 0.45784 7.37179
166 3GDN FAD 0.003729 0.45784 7.37179
167 2XYQ SAH 0.00004831 0.46684 7.37705
168 5E1M PRO PRO LYS ARG ILE ALA 0.00000005092 0.44962 7.46888
169 5E1M SAH 0.00000005092 0.44962 7.46888
170 2EJU SAH 0.0001419 0.44794 7.69231
171 3MQ2 SAH 0.00006293 0.47101 7.79817
172 3VSE SAH 0.00006555 0.49955 8.01282
173 4J1Q NDP 0.002114 0.45348 8.01282
174 2WPF WPF 0.03801 0.43114 8.01282
175 1KPG SAH 0.000004358 0.47321 8.01394
176 1Q0S SAH 0.00008828 0.41784 8.10811
177 4OBW SAM 0.000001465 0.52158 8.17121
178 5THZ SAH 0.000008551 0.56199 8.33333
179 5THY SAH 0.000004962 0.49091 8.33333
180 1L1E SAH 0.000002821 0.48648 8.36237
181 2DPM SAM 0.0005906 0.4043 8.4507
182 3T7S SAM 0.0000005218 0.54356 8.58209
183 4YMH SAH 0.00003885 0.45364 8.75
184 2ZFU SAH 0.000002606 0.58177 8.83721
185 3TLJ SAH 0.00003044 0.44288 8.97436
186 1NW5 SAM 0.000196 0.43577 8.97436
187 4ONQ SFG 0.0004016 0.4318 8.97436
188 1TPY SAH 0.000003848 0.47489 9.05923
189 3C6K SPD 0.0003587 0.50272 9.18635
190 3C6K MTA 0.0003587 0.50272 9.18635
191 3BXO SAM 0.0000006283 0.57757 9.20502
192 3LCC SAH 0.00001773 0.5345 9.3617
193 3VC1 SAH 0.000003165 0.47605 9.61539
194 4QTU SAM 0.000000008776 0.59034 9.62963
195 1IM8 SAI 0.0000001387 0.53687 9.83607
196 1L3I SAH 0.000008593 0.44748 10.4167
197 2GVC FAD 0.0009599 0.47742 10.5769
198 1WY7 SAH 0.00001309 0.45695 10.628
199 4MIG G3F 0.0009413 0.49433 10.8974
200 4TM3 FAD 0.003854 0.47492 10.8974
201 5XLX SAH 0.0009764 0.45535 10.9929
202 1BC5 SAH 0.0001091 0.4294 11.1524
203 1XDS SAM 0.00004805 0.49592 11.4973
204 2YY7 NAD 0.0007346 0.48043 11.859
205 3A4T SFG 0.000006123 0.47174 12.0438
206 3DXY SAM 0.00002868 0.51599 12.3853
207 4ONT SIA GAL BGC 0.01496 0.40607 12.4031
208 1I9G SAM 0.00007383 0.44603 12.5
209 3EGI ADP 0.0006404 0.47185 12.6214
210 3Q87 SAM 0.0002275 0.41219 12.9412
211 5MPT SAH 0.000001113 0.52962 13.141
212 2FK8 SAM 0.000002161 0.49133 13.4615
213 1QZZ SAM 0.0002621 0.46465 13.7821
214 3JWH SAH 0.0000002172 0.61309 13.8249
215 1JNR FAD 0.03498 0.42585 14.6667
216 1U2Z SAH 0.00009464 0.51187 14.7436
217 3OU2 SAH 0.000000932 0.4731 15.5963
218 2JJQ SAH 0.000103 0.47994 15.7051
219 3GDH SAH 0.00004584 0.43212 16.1826
220 1QAN SAH 0.000008012 0.46539 16.3934
221 1XTP SAI 0.0000002435 0.55272 16.5354
222 3DMH SAM 0.00002303 0.45859 16.6667
223 3DMH GMP 0.00004172 0.40979 16.6667
224 3GU3 SAH 0.000001049 0.59054 18.3099
225 1JG3 ADN 0.000182 0.4444 18.5897
226 1KPH SAH 0.000005147 0.47066 19.1638
227 5JE0 AZ8 0.0000001054 0.4677 19.4332
228 5JE0 SAH 0.0000001054 0.4677 19.4332
229 2PXX SAH 0.0000003333 0.53429 19.5349
230 4R6W SAH 0.000001456 0.42469 20.155
231 5JGL SAM 0.00001058 0.501 20.7612
232 3OFK SAH 0.0000009898 0.49756 20.8333
233 5FA8 SAM 0.00008343 0.4268 21.118
234 4M38 SAH 0.0000865 0.44134 23.8095
235 4IWN GEK 0.000000839 0.49641 24.4541
236 5FA5 MTA 0.00007269 0.47524 25
237 1VE3 SAM 0.000004171 0.50783 25.5507
238 1EJ0 SAM 0.000005046 0.50391 26.6667
239 5FTW SAH 0.000002073 0.49988 29.6875
Pocket No.: 2; Query (leader) PDB : 5E9W; Ligand: SAH; Similar sites found: 10
This union binding pocket(no: 2) in the query (biounit: 5e9w.bio2) has 18 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4RDI ATP 0.003531 0.40081 1.38889
2 4LH7 1X8 0.02388 0.40115 2.24359
3 3BGD PM6 0.0002804 0.40655 2.30769
4 5K7U SAM 0.003267 0.40078 2.66667
5 4BLW SAH 0.0001426 0.41022 2.76817
6 3M6W SAM 0.002687 0.41638 3.20513
7 4N9Z V3L 0.04142 0.40035 3.20513
8 1FEC FAD 0.0439 0.40264 5.12821
9 1N2X SAM 0.0004184 0.41148 6.97674
10 3VC1 GST 0.000008129 0.40127 9.61539
Pocket No.: 3; Query (leader) PDB : 5E9W; Ligand: SAH; Similar sites found: 27
This union binding pocket(no: 3) in the query (biounit: 5e9w.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5CLO NS8 0.01163 0.41635 None
2 4D79 ATP 0.001734 0.41798 1.44928
3 1KYQ NAD 0.005922 0.40172 2.18978
4 2GN3 MMA 0.01347 0.40435 2.38095
5 1UKG MMA 0.02456 0.40077 2.38095
6 1J0X NAD 0.01569 0.41958 2.5641
7 4PIO SAH 0.00003604 0.41178 2.5641
8 3CIF G3H 0.02349 0.40345 2.5641
9 3CIF NAD 0.01787 0.40232 2.5641
10 1PS9 NAP 0.01051 0.41051 2.88462
11 4COV GLA GAL 0.02362 0.40131 3.74532
12 4II2 ATP 0.001205 0.41236 3.84615
13 5O4J SAH 0.01869 0.4072 4.0146
14 5O4J 9KH 0.01869 0.4072 4.0146
15 5O4J PJL 0.01801 0.40688 4.0146
16 3Q9N COA 0.01988 0.40013 4.25532
17 1MFI FHC 0.01138 0.4165 4.38596
18 1X14 NAD 0.001726 0.42275 4.80769
19 5DM1 SAH 0.000004142 0.40164 4.86891
20 3WV8 ATP 0.001404 0.41522 5.04587
21 4UZI IMD 0.004991 0.43634 5.44872
22 5N53 8NB 0.005834 0.4298 5.64103
23 1ZMD NAI 0.0004177 0.4046 5.76923
24 2WPF FAD 0.01093 0.4539 8.01282
25 4POO SAM 0.0004051 0.4065 10
26 1X87 NAD 0.001046 0.40306 10.8974
27 5DLY SAH 0.000005459 0.40461 10.9023
Pocket No.: 4; Query (leader) PDB : 5E9W; Ligand: SAH; Similar sites found: 12
This union binding pocket(no: 4) in the query (biounit: 5e9w.bio3) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1SJN DUP 0.003408 0.41086 None
2 2GNB MAN 0.01577 0.41081 2.38095
3 4PIO AVI 0.00005966 0.41301 2.5641
4 3ICT ADP 0.01059 0.40269 2.88462
5 3ICS ADP 0.01157 0.4009 2.88462
6 5FUI APY 0.006861 0.44664 3.0303
7 1TUU AMP 0.01756 0.40029 3.20513
8 2CBZ ATP 0.02492 0.40574 4.16667
9 5DM1 5D7 0.0000008567 0.41576 4.86891
10 5MW4 5JU 0.00002349 0.4073 5.76923
11 1SQL GUN 0.02064 0.40557 6.84932
12 2O66 FLC 0.01953 0.4049 8.14815
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