Receptor
PDB id Resolution Class Description Source Keywords
5EVA 1.45 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE HUMAN BRPF1 BROMODOMAIN IN COMPLEX SEED16 HOMO SAPIENS BROMODOMAIN AND PHD FINGER-CONTAINING PROTEIN 1(BRPF1) MONOLEUKEMIA ZINC-FINGER (MOZ) INHIBITOR TRANSCRIPTION DNA BPROTEIN
Ref.: TWENTY CRYSTAL STRUCTURES OF BROMODOMAIN AND PHD FI CONTAINING PROTEIN 1 (BRPF1)/LIGAND COMPLEXES REVEA CONSERVED BINDING MOTIFS AND RARE INTERACTIONS. J.MED.CHEM. V. 59 5555 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NO3 A:802;
 Invalid;
 none;
 submit data
62.005 N O3 [N+](...
5S9 A:801;
 Valid;
 none;
 submit data
237.205 C11 H9 F2 N3 O Cn1c(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4UYE 1.65 Å NON-ENZYME: OTHER BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-DIMETHYL-2-OXO-6-( PIPERIDIN-1-YL)-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-5-YL-2- M ETHOXYBENZAMIDE HOMO SAPIENS TRANSCRIPTION INHIBITOR HISTONE EPIGENETIC READER ANTAGO
Ref.: 1,3-DIMETHYL BENZIMIDAZOLONES ARE POTENT, SELECTIVE INHIBITORS OF THE BRPF1 BROMODOMAIN. ACS MED.CHEM.LETT. V. 5 1190 2014
Members (37)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 5E3G - 5JQ C5 H4 N4 O2 S C12=C(NC(=....
2 5T4U ic50 = 4800 nM 12Q C10 H9 N O CN1c2ccccc....
3 5EWH Kd = 170 uM 5SG C9 H7 N O c1cc2cnccc....
4 5C85 Kd = 105 uM 4YO C8 H7 Br N2 O c1cc2c(cc1....
5 5E3D Kd = 95 uM 5JL C5 H4 N4 O S2 C12=C(NC(=....
6 5C87 - 4YS C9 H7 N O c1ccc2c(c1....
7 5O4T - 9KT C10 H10 N2 O2 CN1c2ccccc....
8 5OV8 Kd = 18 uM AXN C24 H30 N4 O4 S CC(C)Cc1cc....
9 5O4S ic50 = 3.4 uM 9KW C24 H28 N4 O5 S CN1c2cc(c(....
10 5MWH Kd = 1.8 uM UWX C24 H30 N4 O5 S CC(C)Cc1cc....
11 5DY7 - 5GT C9 H7 F3 N2 O c1cc2c(cc1....
12 5T4V ic50 = 60 nM N48 C19 H17 N3 O4 S CC1=CC(=O)....
13 5DYC - 5GU C8 H7 Br N2 O c1cc2c(cc1....
14 5O55 - 9L5 C19 H23 N5 O2 CCN1c2ccc(....
15 5EQ1 Kd = 21 uM BEA C9 H8 N3 S Cc1cccc2c1....
16 5G4S ic50 = 1 uM 8VI C24 H31 N5 O3 CCN(c1cc2c....
17 5EWC - 5SJ C12 H14 N2 O3 CCOC(=O)c1....
18 5EPR Kd = 91 uM 5QY C9 H10 N2 O C[C@H]1C(=....
19 5EVA - 5S9 C11 H9 F2 N3 O Cn1c(ccn1)....
20 5ETD - 5RN C10 H9 N O CC(=O)c1c[....
21 5DYA - 5GV C11 H12 N2 O3 CC[C@@H]1C....
22 5EV9 - 5SB C14 H12 N4 O CC(=O)Nc1c....
23 5MYG Kd = 31 nM LS8 C19 H17 N3 O4 S CC1=Cc2cc(....
24 5MWZ Kd = 7.1 uM KGU C24 H36 N6 O3 CCN1c2cc(c....
25 5G4R ic50 = 7.943 nM LF1 C22 H27 N5 O3 C[C@@H]1CN....
26 5OWA Kd = 3.5 uM B0H C17 H24 N4 O2 S Cc1c(oc(n1....
27 5EM3 - 5Q0 C9 H7 N O c1cc2c(ccc....
28 5ETB Kd = 29 uM 5RO C11 H11 N O Cc1cccc2c1....
29 4UYE Kd = 9.54 nM 9F9 C22 H26 N4 O3 CN1c2cc(c(....
30 5O5F - 9LT C22 H20 F N5 O3 CCN1c2ccc(....
31 5O5A - 9LN C22 H21 N5 O3 CCN1c2ccc(....
32 5O5H - 9LK C17 H14 Cl N3 O3 Cc1c(oc(n1....
33 5C7N Kd = 0.27 uM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
34 5EPS Kd = 38 uM 5QX C9 H10 N2 O CN1c2ccccc....
35 5MWG ic50 = 1.7 uM WGX C25 H30 N4 O4 S CN1c2cc(c(....
36 5D7X Kd = 15 uM XZ8 C14 H13 N3 O2 CC1=C(C(=O....
37 6EKQ Kd = 10.9 uM B0H C17 H24 N4 O2 S Cc1c(oc(n1....
70% Homology Family (39)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 5E3G - 5JQ C5 H4 N4 O2 S C12=C(NC(=....
2 5T4U ic50 = 4800 nM 12Q C10 H9 N O CN1c2ccccc....
3 5EWH Kd = 170 uM 5SG C9 H7 N O c1cc2cnccc....
4 5C85 Kd = 105 uM 4YO C8 H7 Br N2 O c1cc2c(cc1....
5 5E3D Kd = 95 uM 5JL C5 H4 N4 O S2 C12=C(NC(=....
6 5C87 - 4YS C9 H7 N O c1ccc2c(c1....
7 5O4T - 9KT C10 H10 N2 O2 CN1c2ccccc....
8 5OV8 Kd = 18 uM AXN C24 H30 N4 O4 S CC(C)Cc1cc....
9 5O4S ic50 = 3.4 uM 9KW C24 H28 N4 O5 S CN1c2cc(c(....
10 5MWH Kd = 1.8 uM UWX C24 H30 N4 O5 S CC(C)Cc1cc....
11 5DY7 - 5GT C9 H7 F3 N2 O c1cc2c(cc1....
12 5T4V ic50 = 60 nM N48 C19 H17 N3 O4 S CC1=CC(=O)....
13 5DYC - 5GU C8 H7 Br N2 O c1cc2c(cc1....
14 5O55 - 9L5 C19 H23 N5 O2 CCN1c2ccc(....
15 5EQ1 Kd = 21 uM BEA C9 H8 N3 S Cc1cccc2c1....
16 5G4S ic50 = 1 uM 8VI C24 H31 N5 O3 CCN(c1cc2c....
17 5EWC - 5SJ C12 H14 N2 O3 CCOC(=O)c1....
18 5EPR Kd = 91 uM 5QY C9 H10 N2 O C[C@H]1C(=....
19 5EVA - 5S9 C11 H9 F2 N3 O Cn1c(ccn1)....
20 5ETD - 5RN C10 H9 N O CC(=O)c1c[....
21 5DYA - 5GV C11 H12 N2 O3 CC[C@@H]1C....
22 5EV9 - 5SB C14 H12 N4 O CC(=O)Nc1c....
23 5MYG Kd = 31 nM LS8 C19 H17 N3 O4 S CC1=Cc2cc(....
24 5MWZ Kd = 7.1 uM KGU C24 H36 N6 O3 CCN1c2cc(c....
25 5G4R ic50 = 7.943 nM LF1 C22 H27 N5 O3 C[C@@H]1CN....
26 5OWA Kd = 3.5 uM B0H C17 H24 N4 O2 S Cc1c(oc(n1....
27 5EM3 - 5Q0 C9 H7 N O c1cc2c(ccc....
28 5ETB Kd = 29 uM 5RO C11 H11 N O Cc1cccc2c1....
29 4UYE Kd = 9.54 nM 9F9 C22 H26 N4 O3 CN1c2cc(c(....
30 5O5F - 9LT C22 H20 F N5 O3 CCN1c2ccc(....
31 5O5A - 9LN C22 H21 N5 O3 CCN1c2ccc(....
32 5O5H - 9LK C17 H14 Cl N3 O3 Cc1c(oc(n1....
33 5C7N Kd = 0.27 uM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
34 5EPS Kd = 38 uM 5QX C9 H10 N2 O CN1c2ccccc....
35 5MWG ic50 = 1.7 uM WGX C25 H30 N4 O4 S CN1c2cc(c(....
36 5D7X Kd = 15 uM XZ8 C14 H13 N3 O2 CC1=C(C(=O....
37 6EKQ Kd = 10.9 uM B0H C17 H24 N4 O2 S Cc1c(oc(n1....
38 3RCW - MB3 C5 H9 N O CN1CCCC1=O
39 5N49 ic50 = 450 nM 8LW C22 H17 N3 O3 Cc1cc2c(cc....
50% Homology Family (64)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 5I7Y Kd = 52 nM 69G C20 H21 N3 O2 C/C=C/CN1C....
2 4UIW ic50 = 0.00000001 M H1B C22 H22 F3 N3 O3 S2 CCN1C=C(c2....
3 4UIV ic50 = 0.00000001 M XZB C21 H20 F3 N3 O3 S2 CN1C=C(c2c....
4 5JI8 Kd = 23.4 uM 6KT C8 H7 N3 O S c1cc2c(cc1....
5 5MKY ic50 = 2 uM I0D C15 H17 Cl N4 O CN1CCc2c(c....
6 4UIU ic50 = 0.00000001 M TVU C22 H24 N2 O6 S2 CN1C=C(c2c....
7 4UIT ic50 = 0.00000001 M N1D C22 H25 N3 O6 S2 CN1C=C(c2c....
8 5I40 ic50 = 13.7 uM 67N C8 H8 N2 O CN1C=Cc2cc....
9 5I7X Kd = 53 nM 67B C17 H17 N3 O2 CN1C=C(c2c....
10 6V1B Kd = 37 nM H1B C22 H22 F3 N3 O3 S2 CCN1C=C(c2....
11 6V0X Kd = 277 uM B49 C22 H27 F N4 O2 CCN(CC)CCN....
12 4XY8 Kd = 397 nM 43U C12 H10 Br N5 O COc1ccc(cc....
13 5IGM Kd = 41.7 nM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
14 4Z6H Kd = 612 nM 4L2 C16 H18 N2 O2 CC1=CC(=O)....
15 6HM0 Kd = 73 nM GBW C50 H64 N8 O9 S Cc1c(scn1)....
16 5F1H Kd = 14.1 nM 5U6 C20 H23 N3 O3 CN1C=C(c2c....
17 5F1L ic50 = 21 nM 5U2 C19 H24 N2 O4 CC1=CC(=CN....
18 5F25 Kd = 9.1 uM 5TU C14 H14 N2 O2 CC1=CC(=CN....
19 4Z6I - 4L3 C27 H31 N3 O4 CC1=CC(=O)....
20 6V0S Kd = 16000 nM EAE C13 H15 N O2 S CCN1c2cc(c....
21 5EU1 Kd = 15.4 nM 5SW C20 H23 N3 O3 CN1C=C(c2c....
22 6V14 Kd = 82 nM QMG C20 H19 N3 O2 Cc1ccc(cc1....
23 5F2P Kd = 37.5 uM 5TY C10 H12 N4 O CN1C=Cc2c(....
24 5E3D Kd = 95 uM 5JL C5 H4 N4 O S2 C12=C(NC(=....
25 5C87 - 4YS C9 H7 N O c1ccc2c(c1....
26 5O4T - 9KT C10 H10 N2 O2 CN1c2ccccc....
27 5OV8 Kd = 18 uM AXN C24 H30 N4 O4 S CC(C)Cc1cc....
28 5O4S ic50 = 3.4 uM 9KW C24 H28 N4 O5 S CN1c2cc(c(....
29 5MWH Kd = 1.8 uM UWX C24 H30 N4 O5 S CC(C)Cc1cc....
30 5DY7 - 5GT C9 H7 F3 N2 O c1cc2c(cc1....
31 5T4V ic50 = 60 nM N48 C19 H17 N3 O4 S CC1=CC(=O)....
32 5DYC - 5GU C8 H7 Br N2 O c1cc2c(cc1....
33 5O55 - 9L5 C19 H23 N5 O2 CCN1c2ccc(....
34 5EQ1 Kd = 21 uM BEA C9 H8 N3 S Cc1cccc2c1....
35 5G4S ic50 = 1 uM 8VI C24 H31 N5 O3 CCN(c1cc2c....
36 5EWC - 5SJ C12 H14 N2 O3 CCOC(=O)c1....
37 5EPR Kd = 91 uM 5QY C9 H10 N2 O C[C@H]1C(=....
38 5EVA - 5S9 C11 H9 F2 N3 O Cn1c(ccn1)....
39 5ETD - 5RN C10 H9 N O CC(=O)c1c[....
40 5DYA - 5GV C11 H12 N2 O3 CC[C@@H]1C....
41 5EV9 - 5SB C14 H12 N4 O CC(=O)Nc1c....
42 5MYG Kd = 31 nM LS8 C19 H17 N3 O4 S CC1=Cc2cc(....
43 5MWZ Kd = 7.1 uM KGU C24 H36 N6 O3 CCN1c2cc(c....
44 5G4R ic50 = 7.943 nM LF1 C22 H27 N5 O3 C[C@@H]1CN....
45 5OWA Kd = 3.5 uM B0H C17 H24 N4 O2 S Cc1c(oc(n1....
46 5EM3 - 5Q0 C9 H7 N O c1cc2c(ccc....
47 5ETB Kd = 29 uM 5RO C11 H11 N O Cc1cccc2c1....
48 4UYE Kd = 9.54 nM 9F9 C22 H26 N4 O3 CN1c2cc(c(....
49 5O5F - 9LT C22 H20 F N5 O3 CCN1c2ccc(....
50 5O5A - 9LN C22 H21 N5 O3 CCN1c2ccc(....
51 5O5H - 9LK C17 H14 Cl N3 O3 Cc1c(oc(n1....
52 5C7N Kd = 0.27 uM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
53 5EPS Kd = 38 uM 5QX C9 H10 N2 O CN1c2ccccc....
54 5MWG ic50 = 1.7 uM WGX C25 H30 N4 O4 S CN1c2cc(c(....
55 5D7X Kd = 15 uM XZ8 C14 H13 N3 O2 CC1=C(C(=O....
56 6EKQ Kd = 10.9 uM B0H C17 H24 N4 O2 S Cc1c(oc(n1....
57 6V1E Kd = 121 nM 5SW C20 H23 N3 O3 CN1C=C(c2c....
58 6V17 Kd = 148 nM H1B C22 H22 F3 N3 O3 S2 CCN1C=C(c2....
59 6V0Q Kd = 4200 nM EAE C13 H15 N O2 S CCN1c2cc(c....
60 6V1H Kd = 114 nM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
61 6V16 Kd = 556 nM QMG C20 H19 N3 O2 Cc1ccc(cc1....
62 6V1F Kd = 418 nM 5U6 C20 H23 N3 O3 CN1C=C(c2c....
63 3RCW - MB3 C5 H9 N O CN1CCCC1=O
64 5N49 ic50 = 450 nM 8LW C22 H17 N3 O3 Cc1cc2c(cc....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 5S9; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 5S9 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: 5S9; Similar ligands found: 457
No: Ligand Similarity coefficient
1 5VU 0.9620
2 0UL 0.9451
3 AP6 0.9431
4 WCU 0.9378
5 PIQ 0.9375
6 9JT 0.9369
7 2PV 0.9363
8 FCW 0.9351
9 2PK 0.9348
10 4GU 0.9343
11 68B 0.9339
12 7EH 0.9327
13 LR2 0.9318
14 0DF 0.9318
15 CBE 0.9317
16 C4E 0.9314
17 ZSP 0.9298
18 NAL 0.9282
19 1HP 0.9280
20 2JX 0.9279
21 4AU 0.9269
22 3IP 0.9265
23 0OK 0.9260
24 F18 0.9250
25 6H2 0.9246
26 5B2 0.9246
27 1V4 0.9244
28 1ZC 0.9241
29 47V 0.9238
30 2P3 0.9235
31 0SY 0.9234
32 H4B 0.9232
33 397 0.9217
34 QME 0.9209
35 WV7 0.9209
36 BIO 0.9204
37 7L4 0.9202
38 833 0.9201
39 OLU 0.9197
40 0ON 0.9194
41 0OO 0.9194
42 3D8 0.9188
43 6DQ 0.9187
44 UAY 0.9179
45 47X 0.9178
46 0NJ 0.9177
47 6QT 0.9174
48 S0D 0.9160
49 P4T 0.9160
50 ZRK 0.9157
51 YE6 0.9155
52 LZ5 0.9151
53 F40 0.9151
54 120 0.9146
55 CUQ 0.9145
56 6J5 0.9144
57 HBI 0.9143
58 C0H 0.9143
59 5NN 0.9142
60 EES 0.9141
61 1YO 0.9140
62 XCG 0.9139
63 3SU 0.9136
64 XYP XYP 0.9134
65 2GQ 0.9132
66 7FZ 0.9129
67 4FC 0.9127
68 11X 0.9123
69 A51 0.9119
70 D64 0.9119
71 AVX 0.9113
72 JCZ 0.9111
73 1FL 0.9110
74 FHV 0.9110
75 801 0.9109
76 D9Z 0.9108
77 848 0.9106
78 20D 0.9105
79 0FR 0.9105
80 JF8 0.9102
81 5E5 0.9101
82 2QV 0.9098
83 5ER 0.9096
84 DFL 0.9095
85 ZTW 0.9090
86 4CN 0.9090
87 KLS 0.9089
88 2QU 0.9088
89 H2B 0.9088
90 LWS 0.9087
91 OA4 0.9087
92 XDL XYP 0.9087
93 9CE 0.9087
94 W23 0.9084
95 1XS 0.9082
96 U13 0.9079
97 AOY 0.9078
98 GB4 0.9074
99 P4L 0.9072
100 4ZF 0.9064
101 XYS XYP 0.9061
102 ERZ 0.9060
103 GJG 0.9058
104 6P3 0.9054
105 GEN 0.9052
106 2L1 0.9051
107 L2K 0.9050
108 1Q4 0.9049
109 XYS XYS 0.9048
110 G14 0.9048
111 CUH 0.9048
112 NQ7 0.9046
113 0X2 0.9045
114 1V1 0.9044
115 A73 0.9041
116 LR8 0.9040
117 1V3 0.9040
118 H75 0.9038
119 GJB 0.9037
120 D25 0.9033
121 WLH 0.9032
122 4AB 0.9031
123 6WR 0.9030
124 FZM 0.9030
125 38E 0.9028
126 26C 0.9027
127 FYR 0.9027
128 3F4 0.9027
129 3GX 0.9026
130 CC5 0.9026
131 RGK 0.9024
132 25F 0.9024
133 122 0.9021
134 ZRL 0.9018
135 SZ5 0.9015
136 AWE 0.9013
137 363 0.9012
138 7AP 0.9012
139 TCC 0.9011
140 JGB 0.9011
141 D1Y 0.9008
142 5ZM 0.9003
143 NPS 0.9001
144 124 0.8999
145 EI1 0.8996
146 AX5 0.8995
147 YZ9 0.8994
148 LVY 0.8993
149 MR6 0.8993
150 6FB 0.8993
151 E6Q 0.8992
152 EQW 0.8991
153 X2M 0.8989
154 7ZO 0.8988
155 XI7 0.8988
156 NIF 0.8986
157 JMG 0.8986
158 5WK 0.8985
159 GB5 0.8984
160 5TO 0.8981
161 AJ1 0.8981
162 SQM 0.8980
163 3VS 0.8980
164 KLE 0.8977
165 4Z1 0.8977
166 X48 0.8976
167 A5Q 0.8976
168 QC1 0.8976
169 STL 0.8975
170 ZZA 0.8973
171 FY8 0.8972
172 TID 0.8971
173 Q4G 0.8970
174 BBY 0.8968
175 A6W 0.8964
176 4CF 0.8963
177 6BK 0.8961
178 XIF XYP 0.8958
179 P2L 0.8957
180 DTY 0.8957
181 TYR 0.8957
182 KW7 0.8955
183 5AD 0.8955
184 J84 0.8955
185 QIV 0.8951
186 M3W 0.8950
187 JF5 0.8948
188 613 0.8948
189 2D2 0.8947
190 IPO 0.8947
191 1A5 0.8947
192 CR4 0.8947
193 AX4 0.8945
194 28A 0.8944
195 TPM 0.8940
196 EAT 0.8938
197 94X 0.8935
198 7G2 0.8934
199 OJD 0.8932
200 HH6 0.8930
201 AJ4 0.8930
202 1AJ 0.8929
203 XYP XIF 0.8929
204 XIL 0.8929
205 27F 0.8927
206 6C5 0.8925
207 6C8 0.8925
208 NE2 0.8924
209 FBC 0.8924
210 42R 0.8922
211 135 0.8920
212 121 0.8915
213 E3X 0.8914
214 G2V 0.8913
215 BMZ 0.8911
216 5TU 0.8911
217 4G2 0.8910
218 JA5 0.8910
219 XYP XDN 0.8909
220 XDN XYP 0.8908
221 6SD 0.8908
222 657 0.8905
223 LWA 0.8904
224 A18 0.8901
225 CDJ 0.8900
226 4BF 0.8899
227 PQM 0.8899
228 IOP 0.8899
229 SWX 0.8897
230 DAH 0.8894
231 J2N 0.8894
232 EF2 0.8893
233 0K7 0.8890
234 NIY 0.8890
235 Y3L 0.8888
236 SJR 0.8888
237 LJ5 0.8888
238 PFF 0.8887
239 DDC 0.8885
240 MHB 0.8882
241 5SJ 0.8882
242 DXK 0.8880
243 HO6 0.8879
244 5TT 0.8878
245 J27 0.8877
246 IQQ 0.8875
247 CHQ 0.8875
248 9FH 0.8871
249 3XH 0.8871
250 LI7 0.8869
251 1UZ 0.8868
252 7EL 0.8867
253 E9L 0.8866
254 4Z9 0.8865
255 KYN 0.8864
256 9UL 0.8864
257 5M2 0.8861
258 1FE 0.8858
259 VUP 0.8851
260 697 0.8851
261 NKI 0.8848
262 CMG 0.8846
263 L5D 0.8846
264 W8L 0.8846
265 VT3 0.8845
266 8CC 0.8845
267 ODK 0.8842
268 1Q1 0.8841
269 92O 0.8840
270 6MW 0.8839
271 8D6 0.8838
272 NK5 0.8838
273 4FF 0.8837
274 4AF 0.8837
275 A05 0.8834
276 DBS 0.8832
277 BP7 0.8832
278 AJG 0.8832
279 NYJ 0.8830
280 FHI 0.8828
281 51Y 0.8825
282 7FU 0.8824
283 Z70 0.8822
284 205 0.8821
285 P81 0.8821
286 7PJ 0.8820
287 H2W 0.8820
288 0XR 0.8820
289 ADN 0.8818
290 NOC 0.8817
291 ARJ 0.8817
292 72D 0.8815
293 M4N 0.8813
294 AUV 0.8813
295 5H6 0.8810
296 DHC 0.8810
297 VC3 0.8810
298 C53 0.8810
299 3WK 0.8808
300 3VQ 0.8807
301 BX4 0.8805
302 4K2 0.8802
303 RVE 0.8798
304 BVS 0.8795
305 PQS 0.8795
306 L15 0.8795
307 VJJ 0.8795
308 MI2 0.8793
309 HRM 0.8793
310 789 0.8792
311 4HB 0.8791
312 6C9 0.8791
313 E9S 0.8790
314 NDD 0.8790
315 IDZ 0.8787
316 PCQ 0.8784
317 Q2S 0.8784
318 TYC 0.8781
319 5BX 0.8780
320 Z21 0.8778
321 C4F 0.8777
322 PTB 0.8776
323 5O6 0.8776
324 NEU 0.8774
325 4UM 0.8772
326 BG8 0.8771
327 6T5 0.8769
328 FMQ 0.8768
329 3VW 0.8768
330 3CA 0.8765
331 II4 0.8765
332 H35 0.8764
333 AMR 0.8764
334 ZEZ 0.8763
335 536 0.8761
336 EQA 0.8759
337 RE2 0.8759
338 7N8 0.8757
339 XEV 0.8756
340 NEO 0.8754
341 TYP 0.8754
342 97K 0.8752
343 FCD 0.8752
344 LOT 0.8750
345 GZV 0.8750
346 G30 0.8748
347 4FE 0.8746
348 F4K 0.8746
349 5CQ 0.8745
350 531 0.8744
351 WDW 0.8742
352 9BF 0.8741
353 OA1 0.8740
354 U14 0.8740
355 92G 0.8740
356 3Y7 0.8737
357 Q11 0.8735
358 KWB 0.8734
359 6WU 0.8732
360 JVD 0.8732
361 LI4 0.8730
362 BNY 0.8727
363 NPX 0.8727
364 IMK 0.8727
365 IS2 0.8726
366 XYP XYS 0.8724
367 T1N 0.8724
368 I2E 0.8724
369 6EN 0.8723
370 1SF 0.8723
371 3RP 0.8723
372 5OO 0.8715
373 A63 0.8714
374 1VK 0.8712
375 B21 0.8709
376 2LT 0.8708
377 C0V 0.8708
378 802 0.8704
379 3NF 0.8703
380 08C 0.8703
381 FF2 0.8701
382 TJM 0.8700
383 4L2 0.8700
384 1DR 0.8700
385 SNV 0.8693
386 6TJ 0.8693
387 15Q 0.8692
388 CK2 0.8690
389 LU2 0.8687
390 PUE 0.8685
391 91F 0.8684
392 QBP 0.8683
393 BZM 0.8680
394 GVY 0.8680
395 3L1 0.8680
396 LUM 0.8679
397 Q9T 0.8678
398 50C 0.8678
399 5C1 0.8678
400 0OY 0.8676
401 DE7 0.8676
402 S0A 0.8671
403 JNW 0.8667
404 5F1 0.8664
405 PLP 0.8663
406 27M 0.8662
407 A7K 0.8659
408 IEE 0.8659
409 TCL 0.8659
410 2J1 0.8653
411 DGO Z61 0.8651
412 TIA 0.8650
413 U4J 0.8648
414 0RY 0.8646
415 C82 0.8644
416 1KN 0.8644
417 RKN 0.8641
418 ENO 0.8641
419 NW1 0.8638
420 6HO 0.8638
421 GVI 0.8636
422 37E 0.8635
423 5CK 0.8634
424 NU3 0.8629
425 KF5 0.8623
426 LJ3 0.8621
427 R9J 0.8621
428 AUY 0.8621
429 TVC 0.8620
430 BXS 0.8619
431 TLF 0.8619
432 TES 0.8619
433 ESE 0.8616
434 LIG 0.8613
435 4FP 0.8610
436 KHP 0.8606
437 YX1 0.8606
438 NFZ 0.8593
439 ID8 0.8587
440 23M 0.8587
441 Q92 0.8585
442 22M 0.8581
443 LZ7 0.8580
444 GXD 0.8573
445 5WN 0.8572
446 7ZL 0.8571
447 D2G 0.8571
448 5UD 0.8570
449 B4L 0.8563
450 FER 0.8558
451 GAL FUC 0.8549
452 DTR 0.8548
453 1BW 0.8544
454 AHR AHR 0.8542
455 EMU 0.8540
456 FMB 0.8528
457 UN4 0.8518
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4UYE; Ligand: 9F9; Similar sites found with APoc: 4
This union binding pocket(no: 1) in the query (biounit: 4uye.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 4YC9 4C1 35.5932
2 6J3O B4L 38.1356
3 5MLJ 9ST 40.1786
4 5ML0 P2L 45.4545
Pocket No.: 2; Query (leader) PDB : 4UYE; Ligand: 9F9; Similar sites found with APoc: 7
This union binding pocket(no: 2) in the query (biounit: 4uye.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 6J3P B8O 38.1356
2 6J3O B4L 38.1356
3 6J3P B8O 38.1356
4 5TPX 7H7 38.9831
5 5MLJ 9ST 40.1786
6 5MLJ 9ST 40.1786
7 5ML0 P2L 45.4545
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