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Receptor
PDB id Resolution Class Description Source Keywords
5F8F 1.9 Å EC: 2.-.-.- RV2258C-SFG MYCOBACTERIUM TUBERCULOSIS H37RV METHYLTRANSFERASE CLASS I SINEFUNGIN S-ADENOSYL-L-HOMOCYSCOMPLEX TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF RV2258C FROM MYCOBACTERIUM TUB H37RV, AN S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE J.STRUCT.BIOL. V. 193 172 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SFG C:400;
B:400;
A:401;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
381.387 C15 H23 N7 O5 c1nc(...
GOL A:403;
A:404;
A:402;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5F8F 1.9 Å EC: 2.-.-.- RV2258C-SFG MYCOBACTERIUM TUBERCULOSIS H37RV METHYLTRANSFERASE CLASS I SINEFUNGIN S-ADENOSYL-L-HOMOCYSCOMPLEX TRANSFERASE
Ref.: CRYSTAL STRUCTURE OF RV2258C FROM MYCOBACTERIUM TUB H37RV, AN S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE J.STRUCT.BIOL. V. 193 172 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 269 families.
1 5F8F - SFG C15 H23 N7 O5 c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 237 families.
1 5F8F - SFG C15 H23 N7 O5 c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 5F8F - SFG C15 H23 N7 O5 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SFG; Similar ligands found: 231
No: Ligand ECFP6 Tc MDL keys Tc
1 SFG 1 1
2 0UM 0.689655 0.887324
3 SAI 0.654762 0.940298
4 SA8 0.642857 0.9
5 SAH 0.635294 0.954545
6 EEM 0.62069 0.875
7 5X8 0.619048 0.924242
8 S7M 0.606742 0.875
9 ADN 0.597222 0.850746
10 RAB 0.597222 0.850746
11 XYA 0.597222 0.850746
12 5CD 0.594595 0.863636
13 5N5 0.581081 0.850746
14 62X 0.574468 0.84
15 A4D 0.573333 0.850746
16 K15 0.568421 0.863014
17 DTA 0.564103 0.84058
18 6RE 0.560976 0.833333
19 SAM 0.555556 0.875
20 EP4 0.551282 0.802817
21 KB1 0.55102 0.887324
22 M2T 0.544304 0.780822
23 SMM 0.537634 0.84
24 MTA 0.5375 0.826087
25 AMP 0.53012 0.77027
26 A 0.53012 0.77027
27 ZAS 0.53012 0.816901
28 LMS 0.53012 0.678571
29 J7C 0.529412 0.84507
30 3DH 0.52439 0.826087
31 GJV 0.523256 0.821918
32 SON 0.522727 0.813333
33 0XU 0.522222 0.938462
34 SRP 0.521277 0.813333
35 SSA 0.521277 0.697674
36 AOC 0.517647 0.826087
37 CA0 0.516854 0.776316
38 5AL 0.516129 0.786667
39 DSZ 0.515464 0.717647
40 AMO 0.515464 0.813333
41 GSU 0.515152 0.738095
42 KH3 0.514286 0.851351
43 ABM 0.511628 0.75
44 A2D 0.511628 0.75
45 A3N 0.511628 0.814286
46 A5A 0.510638 0.682353
47 5CA 0.510417 0.697674
48 SRA 0.505882 0.730769
49 S4M 0.505747 0.792208
50 A3S 0.505618 0.895522
51 A7D 0.505618 0.882353
52 AN2 0.505618 0.74026
53 GAP 0.505376 0.776316
54 54H 0.5 0.666667
55 M33 0.5 0.74026
56 LAD 0.5 0.818182
57 A12 0.5 0.766234
58 ADX 0.5 0.678571
59 Y3J 0.5 0.80303
60 DSH 0.5 0.871429
61 LSS 0.5 0.681818
62 KAA 0.5 0.712644
63 VMS 0.5 0.666667
64 AP2 0.5 0.766234
65 BA3 0.5 0.75
66 SXZ 0.49505 0.875
67 ME8 0.49505 0.775
68 AHX 0.494949 0.759494
69 53H 0.494845 0.659091
70 DAL AMP 0.494845 0.786667
71 TSB 0.494845 0.674419
72 G5A 0.494624 0.697674
73 50T 0.494505 0.74026
74 ADP 0.494382 0.75
75 5AS 0.494382 0.640449
76 AP5 0.494382 0.75
77 B4P 0.494382 0.75
78 F0P 0.490909 0.9
79 GEK 0.489796 0.913043
80 8QN 0.489796 0.786667
81 AT4 0.488889 0.721519
82 5AD 0.486842 0.828125
83 PAJ 0.484848 0.728395
84 52H 0.484536 0.659091
85 AU1 0.483516 0.730769
86 MAO 0.483146 0.782051
87 A3G 0.482759 0.882353
88 NEC 0.482759 0.797101
89 3AM 0.482353 0.733333
90 YAP 0.480769 0.802632
91 7D7 0.480519 0.794118
92 NB8 0.480392 0.782051
93 TXA 0.480392 0.766234
94 NVA LMS 0.48 0.693182
95 ATF 0.479167 0.721519
96 HEJ 0.478261 0.75
97 A3T 0.478261 0.852941
98 ACP 0.478261 0.753247
99 ATP 0.478261 0.75
100 7MD 0.476636 0.775
101 YSA 0.47619 0.697674
102 XAH 0.47619 0.775
103 9ZA 0.474747 0.746835
104 9ZD 0.474747 0.746835
105 APR 0.473118 0.773333
106 5FA 0.473118 0.75
107 AR6 0.473118 0.773333
108 AQP 0.473118 0.75
109 PRX 0.473118 0.753247
110 APC 0.473118 0.766234
111 WAQ 0.470588 0.815789
112 4AD 0.47 0.802632
113 NSS 0.47 0.697674
114 F2R 0.469565 0.756098
115 A5D 0.468085 0.84058
116 RBY 0.468085 0.789474
117 ADV 0.468085 0.789474
118 AD9 0.468085 0.730769
119 AGS 0.468085 0.7125
120 SAP 0.468085 0.7125
121 ADP PO3 0.468085 0.77027
122 MHZ 0.467391 0.782051
123 FA5 0.466667 0.813333
124 PTJ 0.466019 0.7375
125 00A 0.465347 0.746835
126 8X1 0.464646 0.693182
127 D3Y 0.464646 0.869565
128 VRT 0.463158 0.871429
129 GA7 0.462963 0.74359
130 LEU LMS 0.460784 0.674157
131 S8M 0.46 0.859155
132 OOB 0.46 0.786667
133 ADP VO4 0.459184 0.74026
134 VO4 ADP 0.459184 0.74026
135 T99 0.458333 0.721519
136 ANP 0.458333 0.730769
137 TAT 0.458333 0.721519
138 ACQ 0.458333 0.753247
139 B5V 0.456311 0.766234
140 AAT 0.453608 0.847222
141 2AM 0.453488 0.723684
142 8PZ 0.45283 0.697674
143 FYA 0.451923 0.786667
144 YLC 0.451327 0.797468
145 DLL 0.45098 0.786667
146 A3P 0.450549 0.746667
147 YLP 0.45045 0.777778
148 A22 0.45 0.74026
149 ARG AMP 0.449541 0.765432
150 ADP ALF 0.44898 0.7125
151 ALF ADP 0.44898 0.7125
152 2VA 0.446809 0.828571
153 OAD 0.446602 0.776316
154 3UK 0.446602 0.776316
155 80F 0.445378 0.73494
156 TYR AMP 0.444444 0.802632
157 6YZ 0.444444 0.753247
158 IOT 0.443478 0.768293
159 9SN 0.443396 0.7375
160 PR8 0.442308 0.807692
161 P5A 0.442308 0.704545
162 7D5 0.44186 0.714286
163 A1R 0.441176 0.769231
164 7C5 0.440367 0.797297
165 TT8 0.44 0.926471
166 YLA 0.439655 0.777778
167 YLB 0.438596 0.777778
168 3OD 0.438095 0.776316
169 9K8 0.438095 0.655556
170 BIS 0.438095 0.725
171 1ZZ 0.438095 0.753086
172 NVA 2AD 0.4375 0.859155
173 MAP 0.435644 0.7125
174 MYR AMP 0.433962 0.753086
175 NAI 0.433628 0.725
176 SO8 0.43299 0.816901
177 9X8 0.432692 0.734177
178 A6D 0.432692 0.74359
179 25A 0.431373 0.75
180 5SV 0.431373 0.7375
181 TYM 0.429825 0.813333
182 WSA 0.429825 0.705882
183 LAQ 0.428571 0.753086
184 3NZ 0.428571 0.833333
185 A3R 0.427184 0.769231
186 ADQ 0.427184 0.753247
187 8Q2 0.426087 0.674157
188 7MC 0.426087 0.756098
189 B5Y 0.425926 0.75641
190 B5M 0.425926 0.75641
191 LPA AMP 0.424779 0.753086
192 48N 0.424779 0.759494
193 JB6 0.424528 0.746835
194 PPS 0.424242 0.658824
195 AYB 0.423729 0.768293
196 PAP 0.42268 0.736842
197 OVE 0.422222 0.696203
198 3AD 0.421687 0.863636
199 4YB 0.419643 0.72093
200 A2P 0.419355 0.733333
201 CMP 0.419355 0.753425
202 2BA 0.419355 0.743243
203 ADP BMA 0.419048 0.753247
204 4UV 0.418182 0.75641
205 AHZ 0.415929 0.731707
206 QQX 0.41573 0.670886
207 A A 0.415094 0.75
208 AP0 0.413793 0.695122
209 ATP A A A 0.412844 0.76
210 SP1 0.411111 0.705128
211 QQY 0.411111 0.679487
212 ACK 0.411111 0.716216
213 RP1 0.411111 0.705128
214 AFH 0.410714 0.728395
215 4UU 0.410714 0.75641
216 DND 0.408696 0.766234
217 NXX 0.408696 0.766234
218 TXD 0.408696 0.725
219 7D3 0.408602 0.696203
220 CC5 0.407407 0.876923
221 25L 0.407407 0.74026
222 TAD 0.40708 0.75
223 DQV 0.40708 0.763158
224 AMP DBH 0.405405 0.753247
225 TXE 0.405172 0.725
226 AF3 ADP 3PG 0.405172 0.75
227 OMR 0.405172 0.743902
228 MTP 0.404762 0.72973
229 N0B 0.401575 0.777778
230 V3L 0.4 0.773333
231 YLY 0.4 0.768293
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5F8F; Ligand: SFG; Similar sites found with APoc: 753
This union binding pocket(no: 1) in the query (biounit: 5f8f.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 2GDZ NAD 0.749064
2 2EJU SAH 1.32626
3 3KLJ FAD 1.32626
4 1RYI GOA 1.32626
5 1RYI FAD 1.32626
6 2NVK FAD 1.32626
7 6FP4 FAD 1.33779
8 6FP4 E1T 1.33779
9 3H9E NAD 1.44509
10 1PN0 FAD 1.59151
11 1PN0 IPH 1.59151
12 5JJR SAH 1.59151
13 4KGD FAD 1.59151
14 4KGD TDP 1.59151
15 3FG2 FAD 1.59151
16 3UOY FAD 1.59151
17 3UOY NAP 1.59151
18 1GZ4 ATP 1.59151
19 5EZ7 FAD 1.59151
20 5TTJ FAD 1.59151
21 3AB1 FAD 1.66667
22 1WVG APR 1.67131
23 3U31 NAD 1.72414
24 1G55 SAH 1.74927
25 3GF4 FAD 1.79487
26 3GF4 UPG 1.79487
27 3NDJ SAH 1.85676
28 3NDJ JHZ 1.85676
29 1PS9 FAD 1.85676
30 6EL3 NAP 1.85676
31 3ICT FAD 1.85676
32 4OPC PGT 1.85676
33 4OPC FDA 1.85676
34 3ICS FAD 1.85676
35 3ICR FAD 1.85676
36 4BJZ FAD 1.85676
37 4BJZ P3A 1.85676
38 4MRP GSH 1.85676
39 3OZ2 FAD 1.85676
40 4N49 SAM 1.85676
41 3TLJ SAH 1.87668
42 3A4V PYR 1.89274
43 3A4V NAD 1.89274
44 5DF1 58X 1.90217
45 5DF1 NAP 1.90217
46 1ZEM NAD 1.9084
47 2F5X ASP 1.92308
48 3ZEI AWH 1.93548
49 2P41 SAH 1.96721
50 5DY5 5GR 1.97368
51 1OC2 TDX 2.01149
52 1OC2 NAD 2.01149
53 1EK6 UPG 2.01149
54 1EK6 NAI 2.01149
55 2OBF SAH 2.07612
56 2OBF F83 2.07612
57 4GLL NAD 2.07715
58 1ZQ9 SAM 2.10526
59 3PT9 SAH 2.12202
60 3L9W AMP 2.12202
61 3L9W GSH 2.12202
62 2BRY FAD 2.12202
63 2JB2 FAD 2.12202
64 2JB2 PHE 2.12202
65 5G3U ITW 2.12202
66 5G3U FDA 2.12202
67 6F97 FAD 2.12202
68 4TXI FAD 2.12202
69 4MIG G3F 2.12202
70 4FZV SAM 2.12202
71 1LVL FAD 2.12202
72 1R27 MGD 2.12202
73 1LVL NAD 2.12202
74 3HB5 NAP 2.14067
75 2Q7V FAD 2.15385
76 2WA2 SAM 2.17391
77 4MO2 FDA 2.17391
78 4MO2 FAD 2.17391
79 3EVG SAH 2.18182
80 5O42 9JW 2.18978
81 5O42 BGC 2.18978
82 5O42 NAD 2.18978
83 3A4T SFG 2.18978
84 1DL5 SAH 2.2082
85 4USQ FAD 2.21607
86 3X0V FAD 2.21811
87 2PX8 SAH 2.23048
88 5CUQ NSC 2.24719
89 2O07 SPD 2.30263
90 2O07 MTA 2.30263
91 3ZNN FAD 2.30548
92 3ZNN 4WL 2.30548
93 2PWY SAH 2.32558
94 4FN4 NAD 2.3622
95 5X62 SAH 2.38727
96 2ZWA SAH 2.38727
97 3VSE SAH 2.38727
98 5I39 FAD 2.38727
99 1ZK7 FAD 2.38727
100 5KMS FAD 2.38727
101 5KMS NAD 2.38727
102 3HP9 CF1 2.38727
103 4YNU LGC 2.38727
104 4YNU FAD 2.38727
105 4FC7 NAP 2.38727
106 4FC7 COA 2.38727
107 5JWC FAD 2.38727
108 6FDF SAH 2.39521
109 2EWM NAD 2.40964
110 6GAS FAD 2.41692
111 5JCM NAD 2.43902
112 5JCM FAD 2.43902
113 5JCM ISD 2.43902
114 1WG8 SAM 2.45614
115 5KXE 6Y2 2.46914
116 1OYF MHN 2.47934
117 1AE1 NAP 2.5641
118 3A27 SAM 2.57353
119 1VL8 NAP 2.62172
120 4YUW S4M 2.63158
121 4YUW 4JU 2.63158
122 2EFJ SAH 2.65252
123 3EYA FAD 2.65252
124 1MO9 FAD 2.65252
125 2IID FAD 2.65252
126 2IID PHE 2.65252
127 2IVD FAD 2.65252
128 1MO9 KPC 2.65252
129 1REO FAD 2.65252
130 4XQC 13D 2.65252
131 4XQC NAD 2.65252
132 2FR1 NDP 2.65252
133 3NTA FAD 2.65252
134 3NTD FAD 2.65252
135 2E5V FAD 2.65252
136 6F7L FAD 2.65252
137 1N2X SAM 2.65781
138 4KWI NAP 2.6616
139 4KWI 1TJ 2.6616
140 2AE2 PTO 2.69231
141 2AE2 NAP 2.69231
142 1FK8 NAD 2.72374
143 4NBW NAD 2.72374
144 5BJX NAD 2.73224
145 5BJX UDP 2.73224
146 3I7S PYR 2.73973
147 4G5H UD7 2.75482
148 4G5H NAP 2.75482
149 4NBU NAI 2.8
150 3CTY FAD 2.82132
151 3NUG NAD 2.83401
152 2BD0 NAP 2.86885
153 2BGM NAJ 2.8777
154 3WGT QSC 2.88184
155 3WGT FAD 2.88184
156 2C5A GDC 2.90237
157 2C5A NAD 2.90237
158 3GDH SAH 2.90456
159 4O0L NDP 2.90909
160 1QO8 FAD 2.91777
161 3S1S SAH 2.91777
162 1Q1R FAD 2.91777
163 5U8U FAD 2.91777
164 2WOX NDP 2.91777
165 3LAD FAD 2.91777
166 2V3V MGD 2.91777
167 2C7G FAD 2.91777
168 2C7G ODP 2.91777
169 3NT6 FAD 2.91777
170 5LX9 OLB 2.91777
171 1YY5 FAD 2.92398
172 4RF2 NAP 2.94118
173 3V1Y NAD 2.96736
174 5A3B APR 2.9703
175 2VZ0 NAP 2.98507
176 2VZ0 D64 2.98507
177 4Z0H NAD 2.99401
178 3ABI NAD 3.0137
179 5J5Z FAD 3.02419
180 5OJI NAP 3.07692
181 5OJI ISN 3.07692
182 1Q0S SAH 3.0888
183 5J60 FAD 3.125
184 1SB8 UD2 3.125
185 1KPG SAH 3.13589
186 1KPH SAH 3.13589
187 5UR0 NAD 3.15186
188 4ZA2 NAD 3.16206
189 5VN0 FAD 3.18302
190 5VN0 NAI 3.18302
191 5BVA FAD 3.18302
192 5BUK FAD 3.18302
193 5TS5 FAD 3.18302
194 1GET NAP 3.18302
195 1GET FAD 3.18302
196 5Y77 FAD 3.18302
197 5WKC FAD 3.18302
198 5M67 NAD 3.18302
199 2B4R NAD 3.18841
200 2B4R AES 3.18841
201 3QJ4 FAD 3.21637
202 3EVF GTA 3.2491
203 3EVF SAH 3.2491
204 1XHC FAD 3.26975
205 2YX1 SFG 3.27381
206 3LZW NAP 3.31325
207 3LZW FAD 3.31325
208 3EGI ADP 3.39806
209 3H5N ATP 3.39943
210 1O97 FAD 3.40909
211 1O97 AMP 3.40909
212 3RKR NAP 3.43511
213 1E1M FAD 3.44828
214 1E1M NAP 3.44828
215 2NPX NAD 3.44828
216 2NPX FAD 3.44828
217 4M52 FAD 3.44828
218 1FEC FAD 3.44828
219 1E5Q NDP 3.44828
220 1ORR NAD 3.45821
221 5ZI9 FLC 3.46154
222 1Y8Q ATP 3.46821
223 1L1E SAH 3.48432
224 5TWB FAD 3.48837
225 3E1T FAD 3.51562
226 2DPM SAM 3.52113
227 5E9W SAH 3.52564
228 1G0N NDP 3.53357
229 1G0N PHH 3.53357
230 3FRH SAH 3.55731
231 2C29 NAP 3.56083
232 2C29 DQH 3.56083
233 5EJ2 NAD 3.57143
234 4RSL FAD 3.59551
235 5GWT SIN 3.59712
236 5GWT NAD 3.59712
237 1O5I NAD 3.61446
238 1V6A TRE 3.61446
239 4REP FAD 3.63636
240 4HXY NDP 3.65297
241 4C4A SAH 3.71353
242 1V59 FAD 3.71353
243 1V59 NAD 3.71353
244 3A25 SAM 3.71353
245 2QA1 FAD 3.71353
246 5NA1 FAD 3.71353
247 5KOX FAD 3.71353
248 5KOX RFP 3.71353
249 4FWE FAD 3.71353
250 4D04 NAP 3.71353
251 4D04 FAD 3.71353
252 4GUT FAD 3.71353
253 4HSU FAD 3.71353
254 4GUS FAD 3.71353
255 1XDS SAM 3.74332
256 4U36 TNR 3.75
257 4L2I FAD 3.80228
258 3H4V DVP 3.81944
259 3H4V NAP 3.81944
260 1U7T TDT 3.83142
261 1U7T NAD 3.83142
262 1E6W NAD 3.84615
263 3LU1 NAD 3.84615
264 4ZRN NAD 3.84615
265 4K10 NI9 3.8674
266 4ZCC NAI 3.86905
267 4ZCC FAD 3.86905
268 3AFN NAP 3.87597
269 3GCZ SAM 3.90071
270 1X87 NAD 3.97878
271 1RSG FAD 3.97878
272 4DSG FAD 3.97878
273 4DSG UDP 3.97878
274 5FJN FAD 3.97878
275 5FJN BE2 3.97878
276 1COY FAD 3.97878
277 3V1U NAD 3.97878
278 3NKS FAD 3.97878
279 2RGO FAD 3.97878
280 1RKX NAD 3.97878
281 4D79 ATP 3.98551
282 1JNR FAD 4
283 3GEG NAD 4.04858
284 2XYQ SAH 4.09836
285 1UAY ADN 4.13223
286 4EMI FAD 4.14634
287 1H5Q NAP 4.15094
288 5FUB SAH 4.1543
289 3KO8 NAD 4.16667
290 1RPN NDP 4.1791
291 5WUW NAP 4.18118
292 4OSP NAP 4.18251
293 1DSS NAD 4.2042
294 3I53 SAH 4.21687
295 1G60 SAM 4.23077
296 3X0D SAH 4.24403
297 1UWK URO 4.24403
298 1UWK NAD 4.24403
299 1H82 GZZ 4.24403
300 1H82 FAD 4.24403
301 4D7E FAD 4.24403
302 2YG3 FAD 4.24403
303 4CNK FAD 4.24403
304 3G5S FAD 4.24403
305 5MBX SP5 4.24403
306 5MBX FAD 4.24403
307 2GAG NAD 4.28571
308 2GAG FAD 4.28571
309 2GAG FOA 4.28571
310 1W8D NAP 4.30464
311 4PIO SAH 4.33437
312 4PIO AVI 4.33437
313 1D6S MET PLP 4.34783
314 1D6S PLP MET 4.34783
315 2GN4 NDP 4.36047
316 2GN4 UD1 4.36047
317 2OYL IDC 4.3659
318 1JQ3 AAT 4.39189
319 3O7W SAM 4.42177
320 1KEW NAD 4.43213
321 1KEW TYD 4.43213
322 4NTC FAD 4.47761
323 3FZG SAM 4.5
324 5W7R 9Z7 4.50928
325 5W7R SAH 4.50928
326 2CDU FAD 4.50928
327 1D4D FAD 4.50928
328 4IV9 FAD 4.50928
329 3UCL CYH 4.50928
330 3UCL NAP 4.50928
331 3UCL FAD 4.50928
332 1U2Z SAH 4.50928
333 1ELI PYC 4.50928
334 1KNR FAD 4.50928
335 4UCI SAM 4.50928
336 6GAR FAD 4.58453
337 2ZAT NAP 4.61538
338 1YXM ADE 4.62046
339 3ZV6 NAD 4.62633
340 3ZV6 4HB 4.62633
341 1OAA OAA 4.6332
342 1NW5 SAM 4.70219
343 2DKN NAI 4.70588
344 2Q46 NAP 4.74308
345 1YQZ FAD 4.77454
346 4B63 FAD 4.77454
347 4B63 ORN 4.77454
348 4B63 NAP 4.77454
349 1GZ6 NAI 4.77454
350 5GSN NAP 4.77454
351 5GSN FAD 4.77454
352 5GSN MMZ 4.77454
353 1GY8 NAD 4.78589
354 1RJD SAM 4.79042
355 2YY7 NAD 4.80769
356 3VYW SAM 4.87013
357 4BUZ OCZ 4.87805
358 4BUZ NAD 4.87805
359 4BUZ OAD 4.87805
360 1YC5 NCA 4.87805
361 3MAG SAH 4.88599
362 3FXU TSU 4.91803
363 5WGR FAD 4.94753
364 6DUB SAH 4.95496
365 1ZBQ NAD 5.03979
366 5JAQ NAI 5.03979
367 2NYA MGD 5.03979
368 2HQM FAD 5.03979
369 5X68 FAD 5.03979
370 3GMB FAD 5.03979
371 5HXI 5HN 5.03979
372 5HXI FAD 5.03979
373 3WV8 ATP 5.04587
374 3MCT SAH 5.05051
375 1BDB NAD 5.05415
376 5FFF NAP 5.05837
377 5FFF 5XC 5.05837
378 3GD4 FAD 5.08806
379 3GD4 NAD 5.08806
380 3ICC NAP 5.09804
381 6F9Q NAD 5.14706
382 6ARJ BW4 5.15759
383 6ARJ SAH 5.15759
384 5DXA SFG 5.15759
385 5DX1 SFG 5.15759
386 5DX8 SFG 5.15759
387 5DWQ SFG 5.15759
388 5DX0 SFG 5.15759
389 2UYQ SAM 5.16129
390 4IWN GEK 5.24017
391 5YF1 SFG 5.24862
392 5YF1 8V0 5.24862
393 2DTX BMA 5.30303
394 3HDY GDU 5.30504
395 3HDY FDA 5.30504
396 3HDY FAD 5.30504
397 3CGD FAD 5.30504
398 3CGD COA 5.30504
399 3CGD NAD 5.30504
400 3CGB FAD 5.30504
401 5JCA FAD 5.30504
402 5JCA NDP 5.30504
403 2ZXI FAD 5.30504
404 4LHD GLY 5.30504
405 4P8K FAD 5.30504
406 4P8K 38C 5.30504
407 1EDO NAP 5.32787
408 3ELW SAM 5.33333
409 3ELW GP3 5.33333
410 1BXK NAD 5.35211
411 1XG5 NAP 5.37634
412 3HVJ 705 5.42986
413 2V6G NAP 5.49451
414 3FPZ AHZ 5.52147
415 3C6K SPD 5.57029
416 2JJQ SAH 5.57029
417 3C6K MTA 5.57029
418 4J36 1HR 5.57029
419 3S5W FAD 5.57029
420 4J36 FAD 5.57029
421 4JDR FAD 5.57029
422 4TM3 FAD 5.57029
423 4AT0 FAD 5.57029
424 2YVF FAD 5.57029
425 4X9M FAD 5.57029
426 2Y6Q FAD 5.57029
427 2Y6Q I7T 5.57029
428 5UAO FAD 5.57029
429 2E7Z MGD 5.57029
430 1YBH FAD 5.57029
431 5EEH SAH 5.58511
432 5EEH P9P 5.58511
433 5XNC MTA 5.66038
434 4D42 NAP 5.67376
435 4D42 W0I 5.67376
436 4Y30 SAH 5.69801
437 4Y30 49L 5.69801
438 1PR9 NAP 5.7377
439 3D3W NAP 5.7377
440 4YSX FAD 5.76923
441 6EQS BV8 5.81818
442 2RAB NAD 5.83153
443 2RAB FAD 5.83153
444 1QAN SAH 5.83554
445 4J1Q NDP 5.83554
446 1I8T FAD 5.83554
447 4C3Y FAD 5.83554
448 4C3Y ANB 5.83554
449 5XWV 8H6 5.83554
450 5XWV NDP 5.83554
451 4U8P UDP 5.83554
452 4DMG SAM 5.85242
453 4DCM SAM 5.86667
454 1S7G NAD 5.92885
455 3RFV 15L 5.99251
456 3RFV NAI 5.99251
457 5FA5 MTA 6
458 3FPF TNA 6.04027
459 3FPF MTA 6.04027
460 4X60 3XV 6.04651
461 4X60 SFG 6.04651
462 4URF NAD 6.04839
463 5T2U NAP 6.04839
464 1XKQ NDP 6.07143
465 2IVF MGD 6.07477
466 2Q28 ADP 6.1008
467 6CZ7 MGD 6.1008
468 4IP7 FLC 6.1008
469 2Q0L FAD 6.10932
470 4GQB 0XU 6.12245
471 3CIF NAD 6.12813
472 3CIF G3H 6.12813
473 3WMX NAD 6.14525
474 4YRY FAD 6.15942
475 4YRY NAD 6.15942
476 3VZS NAP 6.22568
477 2HMT NAI 6.25
478 2WSB NAD 6.29921
479 3RJ5 NAD 6.29921
480 2GV8 FAD 6.36605
481 1VQW FAD 6.36605
482 2GVC FAD 6.36605
483 2XVE FAD 6.36605
484 4MOP 2H5 6.36605
485 2XVF FAD 6.36605
486 3QFA FAD 6.36605
487 2JHP SAH 6.36605
488 5Y1G NAD 6.40244
489 5Y1G AKB 6.40244
490 4M37 SAH 6.41399
491 4M38 SAH 6.41399
492 5Z75 NAD 6.42202
493 1LSS NAD 6.42857
494 3H8V ATP 6.50685
495 1E3W NAD 6.51341
496 4Y9D NAI 6.55738
497 2FK8 SAM 6.60377
498 3TKA SAM 6.62824
499 4EUE NAI 6.6313
500 3Q9T FAY 6.6313
501 3MB5 SAM 6.66667
502 4XU6 TDA 6.66667
503 1BC5 SAH 6.69145
504 1JJV ATP 6.79612
505 5MLR GRQ 6.81265
506 5MLR NAP 6.81265
507 5N0J FAD 6.83761
508 5K4W NAI 6.85358
509 5K4W THR 6.85358
510 5ERG SAM 6.89655
511 3QOX SAH 6.89655
512 4YDD MD1 6.90691
513 4YDD MGD 6.90691
514 4USR FAD 6.92521
515 3CH6 311 6.99301
516 3CH6 NAP 6.99301
517 4J56 FAD 7.01754
518 3VC1 SAH 7.05128
519 3VC1 GST 7.05128
520 1XHL NDP 7.07071
521 4UP5 94W 7.07071
522 4RPL FAD 7.1618
523 4RPL 3UC 7.1618
524 1H9A NAP 7.1618
525 4ONQ SFG 7.1618
526 4AP3 FAD 7.1618
527 4AP3 NAP 7.1618
528 2VPY MGD 7.17949
529 5FEU NAP 7.2165
530 3O03 NAP 7.2165
531 2RH4 EMO 7.22022
532 2BZG SAH 7.32759
533 2YVJ FAD 7.33945
534 5Z2L NDP 7.34694
535 3OID NDP 7.36434
536 3QWI CUE 7.40741
537 3QWI NAP 7.40741
538 3ML1 MGD 7.40741
539 2IV2 MGD 7.42706
540 2C31 ADP 7.42706
541 2C31 TZD 7.42706
542 5ZYN FAD 7.42706
543 2IZ1 ATR 7.42706
544 3F8D FAD 7.43034
545 4ITU 1HS 7.43494
546 4ITU NAI 7.43494
547 4EMJ FAD 7.47664
548 5L95 AMP 7.5
549 1G8K MGD 7.5188
550 3WXB NDP 7.52688
551 5ZBC FAD 7.5388
552 4K26 NDP 7.6087
553 4K26 SFF 7.6087
554 3AYI HCI 7.62829
555 3AYI FAD 7.62829
556 3NYC IAR 7.69231
557 3NYC FAD 7.69231
558 5MW4 5JU 7.78443
559 2F5Z FAD 7.8125
560 3U4C NDP 7.82918
561 1SNY NAP 7.86517
562 1H0H MGD 7.94393
563 5NMX FAD 7.95756
564 5NMX NAP 7.95756
565 3CBG SAH 7.95756
566 2RGJ FAD 7.95756
567 2Z3Y F2N 7.95756
568 2VVM FAD 7.95756
569 2VVL FAD 7.95756
570 2B4Q NAP 7.97101
571 5K7U SAM 8
572 4X7Y SAH 8.0292
573 3BGD SAH 8.07692
574 3BGD PM6 8.07692
575 5YJI 8WO 8.09859
576 5YJI SAH 8.09859
577 1XSE NDP 8.13559
578 3A28 NAD 8.13953
579 3TN7 NJP 8.17121
580 1WY7 SAH 8.21256
581 4K5S FAD 8.22281
582 4K5S PM0 8.22281
583 5HSA FAS 8.22281
584 6H3O FAD 8.22281
585 2EG5 SAH 8.33333
586 4RDI ATP 8.33333
587 4RDH AMP 8.33333
588 2A14 SAH 8.36502
589 2J5V PCA 8.44687
590 3FUU ADN 8.48806
591 3IHG FAD 8.48806
592 5YB7 FAD 8.48806
593 5YB7 ORN 8.48806
594 5IL1 SAM 8.49057
595 4AZW SAM 8.75332
596 6FHO FAD 8.75332
597 5CX6 CDP 8.75332
598 1ZK4 NAP 8.76494
599 1NV8 SAM 8.80282
600 1NV8 MEQ 8.80282
601 6B92 SAH 8.84354
602 2WK1 SAH 8.86525
603 2JAH NDP 8.90688
604 2JAP NDP 8.90688
605 1XCL SAH 8.93617
606 4BLW AMP 8.99654
607 4BLW SAH 8.99654
608 1GTE FAD 9.01857
609 6AIN FAD 9.01857
610 5ODQ FAD 9.01857
611 1J0X NAD 9.03614
612 5E8J SAH 9.09091
613 5GWX SAR 9.15493
614 5GWX SAM 9.15493
615 5XLX SAH 9.21986
616 1NFQ NAI 9.23077
617 3SSO SAH 9.28382
618 2PT9 2MH 9.34579
619 2PT9 S4M 9.34579
620 2VDV SAM 9.34959
621 2AG5 NAD 9.34959
622 1IY8 NAD 9.3633
623 5ICE 2H4 9.375
624 5ICE SAH 9.375
625 4J7U YTZ 9.375
626 4J7U NAP 9.375
627 5K0A FAD 9.39394
628 6ER9 FAD 9.54907
629 6ER9 NAP 9.54907
630 1Z6Z NAP 9.57447
631 4XUC SAM 9.63303
632 4XUC 43G 9.63303
633 1QZZ SAM 9.81432
634 4CQM NAP 9.83607
635 1JA9 NDP 9.85401
636 1EJ0 SAM 10
637 5FWA J7C 10.0796
638 4GKV NAD 10.119
639 1EFV FAD 10.1961
640 1EFV AMP 10.1961
641 5GT9 NAP 10.2662
642 5YEC ATP 10.2941
643 5OCA 9QZ 10.3175
644 3TKY SAH 10.3261
645 6BQ6 TER 10.3448
646 6GFK SAH 10.3586
647 4YAC NAI 10.4377
648 5HJM MTA 10.5114
649 3C3Y SAH 10.5485
650 1P1C SAH 10.5528
651 1RP0 AHZ 10.5634
652 2I7C AAT 10.6007
653 2DKH 3HB 10.6101
654 2DKH FAD 10.6101
655 5THQ NDP 10.6618
656 3SJU NDP 10.7527
657 6CI9 NAP 10.8108
658 6D6Y SAH 10.8753
659 4D5G TPP 10.8753
660 4D5G FAD 10.8753
661 2JBM SRT 11.0368
662 5WL1 CUY 11.1111
663 3BMQ NAP 11.1111
664 5K6A NAP 11.1111
665 4CM9 NAP 11.1111
666 3JQF NAP 11.1111
667 4CME NAP 11.1111
668 5KOK SAH 11.1406
669 5KOK R9T 11.1406
670 5KOK S9T 11.1406
671 4EIP FAD 11.1406
672 1KYZ SAH 11.2329
673 1KYZ FER 11.2329
674 3G89 SAM 11.245
675 3DXY SAM 11.4679
676 1Q7B NAP 11.4754
677 4QTU SAM 11.5385
678 5DLY SAH 11.6541
679 5DLY 5D7 11.6541
680 3K6V CIT 11.8644
681 5ZW3 SAH 12
682 5THY SAH 12.2016
683 5THZ SAH 12.2016
684 1Z45 NAD 12.2016
685 6GKV SAH 12.2507
686 4Q9N NAI 12.4161
687 4OBW SAM 12.4514
688 5MPT SAH 12.4668
689 1GEG NAD 12.8906
690 1RJW ETF 12.9794
691 3GWZ SAH 13.0081
692 3GXO SAH 13.0081
693 4YAG NAI 13.1488
694 1BZL FAD 13.2626
695 1BZL GCG 13.2626
696 5FTW SAH 13.2812
697 4NTD FAD 13.5294
698 1KQF MGD 13.6054
699 5W7M SAH 13.7821
700 3GRU AMP 13.8983
701 3DUW SAH 13.9013
702 1E6E FAD 14.0625
703 2ZIF SAM 14.1414
704 4POO SAM 15
705 3VC3 C6P 15.1163
706 3G2O SAM 15.3846
707 1Z3C SA8 15.7718
708 2WET FAD 15.9151
709 1JG3 ADN 16.1804
710 2PXX SAH 16.2791
711 1IM8 SAI 16.3934
712 3GU3 SAH 16.5493
713 3JWH SAH 16.5899
714 3DMH SAM 17.0604
715 3DMH GMP 17.0604
716 4M73 M72 17.2107
717 4M73 SAH 17.2107
718 3SJ7 NDP 17.2414
719 3QVP FAD 18.5676
720 4R6W PC 18.6047
721 4R6W SAH 18.6047
722 5DM1 SAH 18.7266
723 5DM1 5D7 18.7266
724 1TPY SAH 18.8153
725 3RNM FAD 18.9655
726 3P9C SAH 19.2308
727 5W7K SAH 19.5513
728 5WP4 SAH 19.6286
729 2NXE SAM 20.0787
730 3OFK SAH 20.3704
731 5WP5 SAH 20.4244
732 4II2 ATP 20.4819
733 5M36 9SZ 21.0526
734 5E1M SAH 21.1618
735 5E1M PRO PRO LYS ARG ILE ALA 21.1618
736 3AD8 NAD 21.6749
737 3AD8 PYC 21.6749
738 3AD8 FAD 21.6749
739 4A6D SAM 21.813
740 3LCC SAH 22.1277
741 3Q87 SAM 23.5294
742 2XVM SAH 24.1206
743 5MGZ SAH 24.1525
744 5M58 SAH 24.3478
745 2CFC NAD 24.4
746 1R18 SAH 24.6696
747 1I1N SAH 24.7788
748 1VE3 SAM 26.8722
749 2AOT SAH 29.1096
750 1JQD SAH 29.1096
751 1JQD HSM 29.1096
752 5M37 9SZ 40
753 4OGQ 7PH 41.3793
Pocket No.: 2; Query (leader) PDB : 5F8F; Ligand: SFG; Similar sites found with APoc: 56
This union binding pocket(no: 2) in the query (biounit: 5f8f.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 5UAV TFB 1.86335
2 5UAV NDP 1.86335
3 1GPE FAD 2.12202
4 4UZI IMD 2.12202
5 5OC1 FAD 2.38727
6 4BV6 FAD 2.43408
7 5UI2 SUC 2.52366
8 4ZUL UN1 2.53411
9 4JB1 FAD 2.64706
10 4JB1 NAP 2.64706
11 2B9W FAD 2.65252
12 1RLZ NAD 2.71003
13 2WPF FAD 3.18302
14 6DEN G8A 3.18302
15 6DEN FAD 3.18302
16 6DEN TP9 3.18302
17 1T9D PYD 3.18302
18 1T9D 1MM 3.18302
19 1T9D P25 3.18302
20 1T9D FAD 3.18302
21 2R40 EPH 3.44828
22 2JL1 NAP 3.48432
23 3GDN FAD 3.71353
24 3GDN HBX 3.71353
25 5BRT CH9 3.92491
26 5BRT FAD 3.92491
27 3G08 FEE 4.0404
28 4EMI NAD 4.14634
29 5YRG BGC GLC 4.22535
30 5YFT RI2 4.32099
31 2PK3 A2R 4.36137
32 3LXD FAD 4.50928
33 4HA6 FAD 5.11811
34 3WUR O4B 5.26316
35 4YKG FAD 5.30504
36 4YKG NAD 5.30504
37 1UVC STE 5.49451
38 5EIN NAP 5.55556
39 4U8P FDA 5.83554
40 5MIT FAD 6.11621
41 5MIT NAP 6.11621
42 4JNA FAD 6.17647
43 1NAA ABL 6.89655
44 1NAA 6FA 6.89655
45 1RL4 BRR 6.91489
46 4F7E 0SH 7.14286
47 3L9R L9R 7.14286
48 3RMK BML 7.22892
49 1T0S BML 7.69231
50 1FL2 FAD 8.3871
51 3AXB FAD 8.48806
52 3AXB PRO 8.48806
53 5YRJ BGC GLC 9.15493
54 5WL1 D3D 11.1111
55 3HUJ AGH 11.1111
56 4TO8 FLC 11.3014
Pocket No.: 3; Query (leader) PDB : 5F8F; Ligand: SFG; Similar sites found with APoc: 19
This union binding pocket(no: 3) in the query (biounit: 5f8f.bio2) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 2AQJ TRP 2.38727
2 1SB8 NAD 3.125
3 2GMH FAD 3.18302
4 6DNT NAD 3.19767
5 5WQP NAP 3.4188
6 5WQP NCA 3.4188
7 1COY AND 3.97878
8 5DCH 1YO 4.16667
9 4Z24 FAD 4.24403
10 5EB4 FAD 4.50928
11 3RUG DB6 5.39419
12 2YVF NAD 5.57029
13 1GEE NAD 8.42912
14 1ZK4 AC0 8.76494
15 2XRH NIO 11
16 4NBT NAD 11.25
17 5LW0 AR6 11.2554
18 5Z84 CHD 12.3288
19 3AY6 NAI 14.8699
Pocket No.: 4; Query (leader) PDB : 5F8F; Ligand: SFG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 5f8f.bio2) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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