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Receptor
PDB id Resolution Class Description Source Keywords
5FA5 2.34 Å EC: 2.1.1.125 CRYSTAL STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH MTA AND H4 HOMO SAPIENS METHYL TRANSFERASE TRANSFERASE-PROTEIN BINDING COMPLEX
Ref.: DISORDERED METHIONINE METABOLISM IN MTAP/CDKN2A-DEL CANCERS LEADS TO DEPENDENCE ON PRMT5. SCIENCE V. 351 1208 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MTA A:701;
Valid;
none;
ic50 = 4.6 uM
297.334 C11 H15 N5 O3 S CSC[C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5FA5 2.34 Å EC: 2.1.1.125 CRYSTAL STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH MTA AND H4 HOMO SAPIENS METHYL TRANSFERASE TRANSFERASE-PROTEIN BINDING COMPLEX
Ref.: DISORDERED METHIONINE METABOLISM IN MTAP/CDKN2A-DEL CANCERS LEADS TO DEPENDENCE ON PRMT5. SCIENCE V. 351 1208 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 5FA5 ic50 = 4.6 uM MTA C11 H15 N5 O3 S CSC[C@@H]1....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 5FA5 ic50 = 4.6 uM MTA C11 H15 N5 O3 S CSC[C@@H]1....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 5FA5 ic50 = 4.6 uM MTA C11 H15 N5 O3 S CSC[C@@H]1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MTA; Similar ligands found: 267
No: Ligand ECFP6 Tc MDL keys Tc
1 MTA 1 1
2 DTA 0.786885 0.867647
3 3DH 0.777778 0.938462
4 ADN 0.758621 0.878788
5 RAB 0.758621 0.878788
6 XYA 0.758621 0.878788
7 DSH 0.705882 0.84507
8 5N5 0.704918 0.878788
9 A4D 0.693548 0.907692
10 5CD 0.693548 0.892308
11 EP4 0.6875 0.939394
12 M2T 0.676923 0.940298
13 A7D 0.657534 0.882353
14 5X8 0.64 0.895522
15 5AD 0.639344 0.857143
16 AMP 0.628571 0.794521
17 A 0.628571 0.794521
18 ZAS 0.628571 0.816901
19 LMS 0.628571 0.719512
20 A5D 0.623377 0.867647
21 SAH 0.615385 0.869565
22 ABM 0.60274 0.821918
23 J7C 0.60274 0.794521
24 AAT 0.6 0.797297
25 6RE 0.597222 0.783784
26 SRA 0.597222 0.776316
27 S4M 0.594595 0.84
28 AOC 0.589041 0.880597
29 MAO 0.586667 0.805195
30 S8M 0.583333 0.833333
31 A2D 0.581081 0.773333
32 A3N 0.581081 0.867647
33 5AS 0.578947 0.697674
34 GJV 0.573333 0.773333
35 A12 0.565789 0.74359
36 AP2 0.565789 0.74359
37 BA3 0.565789 0.773333
38 AU1 0.564103 0.753247
39 ADX 0.564103 0.719512
40 M33 0.564103 0.810811
41 MHZ 0.564103 0.805195
42 B4P 0.558442 0.773333
43 AP5 0.558442 0.773333
44 ADP 0.558442 0.773333
45 7D7 0.553846 0.794118
46 Y3J 0.552239 0.80303
47 AN2 0.551282 0.763158
48 AT4 0.551282 0.766234
49 SON 0.551282 0.74359
50 SXZ 0.550562 0.849315
51 PRX 0.55 0.8
52 A6D 0.545455 0.766234
53 CA0 0.544304 0.753247
54 AD9 0.54321 0.753247
55 SA8 0.54321 0.873239
56 EEM 0.542169 0.849315
57 ACP 0.5375 0.753247
58 SFG 0.5375 0.826087
59 50T 0.5375 0.763158
60 HEJ 0.5375 0.773333
61 ATP 0.5375 0.773333
62 5FA 0.530864 0.773333
63 AQP 0.530864 0.773333
64 APC 0.530864 0.74359
65 APR 0.530864 0.773333
66 AR6 0.530864 0.773333
67 ANP 0.53012 0.753247
68 SAM 0.53012 0.875
69 SMM 0.529412 0.84
70 3AM 0.527027 0.756757
71 NEC 0.526316 0.823529
72 RBY 0.52439 0.74359
73 AGS 0.52439 0.75641
74 SAP 0.52439 0.75641
75 ADP PO3 0.52439 0.794521
76 ADV 0.52439 0.74359
77 5AL 0.52381 0.786667
78 54H 0.523256 0.705882
79 VMS 0.523256 0.705882
80 3AD 0.521739 0.863636
81 MTH 0.520548 0.984127
82 G5A 0.518072 0.678161
83 SAI 0.518072 0.830986
84 A5A 0.517647 0.722892
85 ME8 0.516484 0.797468
86 GAP 0.511905 0.753247
87 ACQ 0.511905 0.753247
88 T99 0.511905 0.766234
89 TAT 0.511905 0.766234
90 S7M 0.511628 0.824324
91 8QN 0.511364 0.786667
92 9ZD 0.511364 0.769231
93 9ZA 0.511364 0.769231
94 CC5 0.507463 0.876923
95 A3G 0.506494 0.828571
96 A3P 0.506329 0.77027
97 52H 0.505747 0.697674
98 NVA LMS 0.5 0.693182
99 7D5 0.5 0.714286
100 8X1 0.5 0.655556
101 53H 0.5 0.697674
102 ALF ADP 0.5 0.734177
103 ATF 0.5 0.74359
104 TSB 0.5 0.714286
105 MTP 0.5 0.828571
106 MAP 0.5 0.734177
107 ADP ALF 0.5 0.734177
108 DAL AMP 0.5 0.786667
109 25A 0.494382 0.773333
110 5SV 0.494382 0.759494
111 VO4 ADP 0.494253 0.763158
112 6YZ 0.494253 0.753247
113 ADP VO4 0.494253 0.763158
114 SRP 0.494253 0.74359
115 SSA 0.494253 0.678161
116 2AM 0.493333 0.746667
117 26A 0.492958 0.867647
118 PAJ 0.488889 0.75
119 LSS 0.488889 0.701149
120 A1R 0.488889 0.725
121 DSZ 0.488889 0.678161
122 ADQ 0.488889 0.753247
123 0UM 0.488889 0.810811
124 A3R 0.488889 0.725
125 3OD 0.483871 0.776316
126 AHX 0.483516 0.716049
127 62X 0.483516 0.815789
128 5CA 0.483146 0.678161
129 A22 0.483146 0.763158
130 A3T 0.481928 0.880597
131 2VA 0.481928 0.855072
132 RP1 0.480519 0.75
133 SP1 0.480519 0.75
134 3L1 0.478873 0.8
135 3D1 0.478873 0.8
136 OAD 0.478261 0.776316
137 LEU LMS 0.478261 0.693182
138 9X8 0.478261 0.779221
139 K15 0.478261 0.813333
140 OOB 0.477778 0.763158
141 GEK 0.477778 0.833333
142 A3S 0.47561 0.84058
143 OVE 0.474359 0.74026
144 P5A 0.473118 0.648352
145 PR8 0.473118 0.698795
146 NSS 0.472527 0.678161
147 4AD 0.472527 0.734177
148 AMO 0.472527 0.74359
149 2FA 0.472222 0.816901
150 6MD 0.472222 0.893939
151 NOC 0.471429 0.791045
152 NVA 2AD 0.470588 0.833333
153 A2P 0.469136 0.756757
154 2BA 0.469136 0.767123
155 CMP 0.469136 0.777778
156 9K8 0.468085 0.674157
157 PTJ 0.468085 0.759494
158 TXA 0.468085 0.766234
159 1ZZ 0.468085 0.731707
160 QQX 0.467532 0.714286
161 DLL 0.467391 0.763158
162 00A 0.467391 0.725
163 5F1 0.465753 0.782609
164 MYR AMP 0.463158 0.731707
165 3UK 0.462366 0.753247
166 ADP BMA 0.462366 0.753247
167 QQY 0.461538 0.723684
168 ACK 0.461538 0.739726
169 WAQ 0.457447 0.725
170 LAD 0.457447 0.707317
171 A A 0.457447 0.773333
172 B5V 0.457447 0.74359
173 GSU 0.457447 0.678161
174 KAA 0.457447 0.655556
175 PPS 0.454545 0.698795
176 B5Y 0.453608 0.75641
177 B5M 0.453608 0.75641
178 PAP 0.453488 0.76
179 BIS 0.452632 0.725
180 JB6 0.452632 0.746835
181 NB8 0.452632 0.716049
182 FYA 0.452632 0.763158
183 1DA 0.452055 0.878788
184 XAH 0.44898 0.690476
185 SO8 0.448276 0.869565
186 VRT 0.448276 0.84507
187 25L 0.447917 0.763158
188 KB1 0.447917 0.786667
189 4UV 0.444444 0.734177
190 9SN 0.443299 0.716049
191 V3L 0.443182 0.773333
192 LAQ 0.441176 0.710843
193 7D3 0.439024 0.696203
194 FA5 0.438776 0.74359
195 YAP 0.438776 0.734177
196 ATP A A A 0.438776 0.783784
197 8PZ 0.438776 0.678161
198 J1A 0.4375 0.740741
199 LPA AMP 0.436893 0.710843
200 J1C 0.435897 0.67033
201 7MD 0.435644 0.690476
202 AFH 0.435644 0.707317
203 GA7 0.435644 0.789474
204 4UU 0.435644 0.734177
205 J1B 0.434783 0.67033
206 YSA 0.434343 0.678161
207 4UW 0.432692 0.75
208 TXD 0.432692 0.746835
209 ARJ 0.432432 0.776119
210 MCF 0.432099 0.842857
211 GTA 0.431373 0.731707
212 TAD 0.431373 0.728395
213 KH3 0.431373 0.802632
214 4YB 0.431373 0.662921
215 TYR AMP 0.43 0.734177
216 AMP DBH 0.43 0.753247
217 IVH 0.428571 0.813333
218 AHZ 0.427184 0.731707
219 3NZ 0.427083 0.833333
220 7C5 0.425743 0.773333
221 G3A 0.425743 0.716049
222 2A5 0.425287 0.708861
223 7MC 0.424528 0.694118
224 AP0 0.424528 0.7375
225 TT8 0.423913 0.898551
226 YLP 0.423077 0.694118
227 48N 0.423077 0.7375
228 CNA 0.422018 0.74359
229 ARG AMP 0.421569 0.682353
230 AR6 AR6 0.421569 0.773333
231 G5P 0.421569 0.716049
232 ATR 0.420455 0.746667
233 101 0.419753 0.714286
234 D3Y 0.419355 0.816901
235 NXX 0.419048 0.74359
236 DND 0.419048 0.74359
237 6V0 0.419048 0.716049
238 NAX 0.419048 0.698795
239 NAI 0.419048 0.725
240 7D4 0.418605 0.696203
241 DQV 0.417476 0.763158
242 A A A 0.416667 0.763158
243 OMR 0.415094 0.722892
244 TXE 0.415094 0.725
245 649 0.415094 0.648352
246 D5M 0.414634 0.714286
247 DA 0.414634 0.714286
248 139 0.412844 0.698795
249 T5A 0.412844 0.694118
250 ADJ 0.412844 0.702381
251 YLB 0.411215 0.714286
252 YLC 0.411215 0.710843
253 F0P 0.411215 0.797297
254 8Q2 0.411215 0.655556
255 J1D 0.410714 0.628866
256 AYB 0.409091 0.705882
257 A2R 0.408602 0.763158
258 A4P 0.407407 0.659091
259 UP5 0.40566 0.734177
260 F2R 0.405405 0.674419
261 IOT 0.40367 0.666667
262 6CR 0.402597 0.805556
263 WSA 0.401869 0.686047
264 TYM 0.401869 0.74359
265 AF3 ADP 3PG 0.401869 0.707317
266 4TA 0.401786 0.702381
267 YLA 0.4 0.674419
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: 856
This union binding pocket(no: 1) in the query (biounit: 5fa5.bio4) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 3Q9T FAY 1.38648
2 3HDY GDU 2.17984
3 3HDY FDA 2.17984
4 3HDY FAD 2.17984
5 2EFJ SAH 2.17984
6 4FWE FAD 2.17984
7 2JHP SAH 2.17984
8 1VQW FAD 2.18818
9 2GV8 FAD 2.23714
10 2GVC FAD 2.23714
11 4TXI FAD 2.27642
12 2HQM FAD 2.29645
13 3WDM ADN 2.29885
14 1R6D NAD 2.37389
15 1R6D DAU 2.37389
16 3SSO SAH 2.38663
17 4UCI SAM 2.40964
18 1FP1 SAH 2.41935
19 3EGI ADP 2.42718
20 4RDH AMP 2.43056
21 4RDI ATP 2.43056
22 4J7U YTZ 2.43056
23 4J7U NAP 2.43056
24 3TKY SAH 2.45232
25 1RM0 NAI 2.45232
26 1RM0 D6P 2.45232
27 1C0I FAD 2.47934
28 1C0I BE2 2.47934
29 3AB1 FAD 2.5
30 1XKQ NDP 2.5
31 3WMX NAD 2.51397
32 5EZ7 FAD 2.55102
33 5JAQ NAI 2.61538
34 3GMB FAD 2.6506
35 5TUK FAD 2.69608
36 3G5S FAD 2.7088
37 5X62 SAH 2.70936
38 3GWZ SAH 2.71003
39 3GXO SAH 2.71003
40 6F7L FAD 2.71493
41 3TLJ SAH 2.7248
42 1SB8 NAD 2.7248
43 1SB8 UD2 2.7248
44 3X0V FAD 2.7248
45 2IV2 MGD 2.76923
46 4FZV SAM 2.78552
47 2BRY FAD 2.8169
48 2JJQ SAH 2.82353
49 1Z6Z NAP 2.83688
50 1LVL FAD 2.83843
51 1LVL NAD 2.83843
52 5O98 NAP 2.83912
53 4BUZ OAD 2.84553
54 4BUZ OCZ 2.84553
55 1YC5 NCA 2.84553
56 4BUZ NAD 2.84553
57 5JWC FAD 2.87908
58 1RYI GOA 2.87958
59 1RYI FAD 2.87958
60 5W7K SAH 2.88462
61 5W7M SAH 2.88462
62 5HXI 5HN 2.90237
63 5HXI FAD 2.90237
64 1RSG FAD 2.90698
65 2NPX FAD 2.90828
66 2NPX NAD 2.90828
67 1KYQ NAD 2.91971
68 2ZIF SAM 2.92308
69 3SQP FAD 2.92887
70 3MAG SAH 2.9316
71 5U19 SAH 2.93255
72 5U19 827 2.93255
73 1I2B UPG 2.9703
74 1I2B USQ 2.9703
75 1I2B NAD 2.9703
76 3GD4 FAD 2.99728
77 3GD4 NAD 2.99728
78 4RPL FAD 2.99728
79 4RPL 3UC 2.99728
80 3S5W FAD 2.99728
81 5MZI FAD 2.99728
82 5MZI FYK 2.99728
83 5Y77 FAD 2.99728
84 4J1Q NDP 2.99728
85 6BWL NAD 3.04878
86 5WGR FAD 3.07692
87 6DEN FAD 3.07692
88 6DEN G8A 3.07692
89 6DEN TP9 3.07692
90 3F8D FAD 3.09598
91 3NYC IAR 3.14961
92 3NYC FAD 3.14961
93 6DNT NAD 3.19767
94 5WKC FAD 3.23077
95 1T9D FAD 3.23077
96 2BGM NAJ 3.23741
97 5KVA SAM 3.23741
98 2GMH FAD 3.25342
99 1YQZ FAD 3.26975
100 5BUK FAD 3.26975
101 1YBH FAD 3.26975
102 4OPC FDA 3.26975
103 4OPC PGT 3.26975
104 1YXM ADE 3.30033
105 4RF2 NAP 3.30882
106 5DM1 5D7 3.37079
107 5DM1 SAH 3.37079
108 4AZW SAM 3.39703
109 5GT9 NAP 3.42205
110 2AOT SAH 3.42466
111 4BV6 FAD 3.44828
112 2XOC ADP 3.44828
113 2ZXI FAD 3.45369
114 2FK8 SAM 3.45912
115 5TS5 FAD 3.5124
116 5FJN BE2 3.54223
117 5FJN FAD 3.54223
118 2NVK FAD 3.54223
119 3CGD FAD 3.54223
120 3CGD COA 3.54223
121 3CGB FAD 3.54223
122 3CGD NAD 3.54223
123 2C5A NAD 3.54223
124 2C5A GDC 3.54223
125 3LCV SAM 3.55872
126 4NBU NAI 3.6
127 4Y9D NAI 3.60656
128 2IID PHE 3.61446
129 2IID FAD 3.61446
130 4D79 ATP 3.62319
131 6EQS BV8 3.63636
132 4ONQ SFG 3.64146
133 2JAH NDP 3.64372
134 2JAP NDP 3.64372
135 3RIY NAD 3.663
136 5THQ NDP 3.67647
137 3JWH SAH 3.68664
138 3FUU ADN 3.69004
139 2VZ0 NAP 3.73134
140 2VZ0 D64 3.73134
141 3LST SAH 3.73563
142 4N49 SAM 3.73832
143 2PK3 A2R 3.73832
144 1NW5 SAM 3.76176
145 1LTH OXM 3.76176
146 5XNC MTA 3.77358
147 1DL5 SAH 3.78549
148 2DTX BMA 3.78788
149 2A14 SAH 3.80228
150 3AXB PRO 3.81471
151 3AXB FAD 3.81471
152 5Z75 NAD 3.81471
153 2IVD FAD 3.81471
154 5MLR GRQ 3.81471
155 5MLR NAP 3.81471
156 3BMQ NAP 3.81944
157 5K6A NAP 3.81944
158 3JQF NAP 3.81944
159 3JQ9 NAP 3.81944
160 6F97 FAD 3.84615
161 4NBW NAD 3.89105
162 5BVA FAD 3.91198
163 2O07 SPD 3.94737
164 2O07 MTA 3.94737
165 2WPB ZZI 3.94737
166 5Y1G AKB 3.96341
167 5Y1G NAD 3.96341
168 3G89 SAM 4.01606
169 4YNU LGC 4.02802
170 4YNU FAD 4.02802
171 5K4W NAI 4.04984
172 5K4W THR 4.04984
173 5F2K OCA 4.07609
174 5F2K SAH 4.07609
175 1G55 SAH 4.08163
176 6B92 SAH 4.08163
177 5KOK SAH 4.08719
178 1GY8 NAD 4.08719
179 2XVF FAD 4.08719
180 1GET NAP 4.08719
181 1GET FAD 4.08719
182 5KOK S9T 4.08719
183 5KOK R9T 4.08719
184 4XQC NAD 4.08719
185 4XQC 13D 4.08719
186 2VZZ SCA 4.12844
187 3GDH SAH 4.14938
188 5GSN NAP 4.19426
189 5GSN FAD 4.19426
190 5GSN MMZ 4.19426
191 4CS9 AMP 4.2328
192 2Q1S NAI 4.24403
193 1OAA OAA 4.2471
194 5XLX SAH 4.25532
195 3A28 NAD 4.26357
196 6GKV SAH 4.2735
197 3TN7 NJP 4.28016
198 5A3B APR 4.29043
199 3FPZ AHZ 4.29448
200 3CBG SAH 4.31034
201 2RAB NAD 4.31965
202 2RAB FAD 4.31965
203 3ZNN FAD 4.32277
204 3ZNN 4WL 4.32277
205 5LW0 AR6 4.329
206 2WA2 SAM 4.34783
207 4CNK FAD 4.35967
208 1I8T FAD 4.35967
209 2EJU SAH 4.35967
210 1YY5 FAD 4.35967
211 2DKH FAD 4.35967
212 2DKH 3HB 4.35967
213 5TTJ FAD 4.35967
214 3GF4 UPG 4.35967
215 3GF4 FAD 4.35967
216 4X7Y SAH 4.37956
217 1H82 FAD 4.44915
218 1H82 GZZ 4.44915
219 5BW4 SAM 4.49438
220 2OBF SAH 4.49827
221 2OBF F83 4.49827
222 3H4V NAP 4.51389
223 3H4V DVP 4.51389
224 1N5D NDP 4.51389
225 4NEC SAH 4.54545
226 1NJR XYL 4.57746
227 3UOY FAD 4.58716
228 3UOY NAP 4.58716
229 4D42 W0I 4.60993
230 4D42 NAP 4.60993
231 6H3O FAD 4.63215
232 2GN4 UD1 4.63215
233 2GN4 NDP 4.63215
234 4J36 1HR 4.63215
235 4J36 FAD 4.63215
236 5FFF 5XC 4.63215
237 5FFF NAP 4.63215
238 1PJS NAD 4.63215
239 3FG2 FAD 4.70297
240 4USR FAD 4.70914
241 1JQ3 AAT 4.72973
242 3A4T SFG 4.74453
243 6GFK SAH 4.78088
244 1ZK4 AC0 4.78088
245 1ZK4 NAP 4.78088
246 2YY7 NAD 4.80769
247 3LZW NAP 4.81928
248 3LZW FAD 4.81928
249 3NKS FAD 4.8218
250 5MIT FAD 4.89297
251 5MIT NAP 4.89297
252 4E70 N7I 4.89691
253 5O42 9JW 4.90463
254 5O42 NAD 4.90463
255 5O42 BGC 4.90463
256 5OC1 FAD 4.90463
257 3NT6 FAD 4.90463
258 3NTA FAD 4.90463
259 3FXU TSU 4.91803
260 2DPM SAM 4.92958
261 5NMX FAD 4.94118
262 5NMX NAP 4.94118
263 5TWB FAD 4.94186
264 3LU1 NAD 4.94506
265 4PIO SAH 4.95356
266 4PIO AVI 4.95356
267 5FA8 SAM 4.96894
268 3BGD PM6 5
269 3BGD SAH 5
270 6C8R EQV 5.01319
271 6C8R SAH 5.01319
272 1WVG APR 5.01393
273 3MQ2 SAH 5.04587
274 2VVM FAD 5.05051
275 2VVL FAD 5.05051
276 2XVE FAD 5.17711
277 4EUE NAI 5.17711
278 3LXD FAD 5.17711
279 3NTD FAD 5.17711
280 5TUF FAD 5.17711
281 5TUF TDC 5.17711
282 4EIP FAD 5.17711
283 2CFC NAD 5.2
284 2JK0 ASP 5.23077
285 3E1T FAD 5.27344
286 1NV8 MEQ 5.28169
287 1NV8 SAM 5.28169
288 5YJI 8WO 5.28169
289 5YJI SAH 5.28169
290 5YEC ATP 5.29412
291 5F7J ADE 5.3125
292 5X68 FAD 5.37084
293 4RSL FAD 5.39326
294 3AFN NAP 5.42636
295 6GAS FAD 5.43807
296 6GAR FAD 5.44413
297 5K0A FAD 5.45455
298 5BJX NAD 5.46448
299 5BJX UDP 5.46448
300 1FL2 FAD 5.48387
301 3C3Y SAH 5.48523
302 1BC5 SAH 5.57621
303 5YJF SAH 5.6338
304 5YJF 8WO 5.6338
305 5M58 SAH 5.65217
306 1RJD SAM 5.68862
307 6FDF SAH 5.68862
308 1U2Z SAH 5.72207
309 4DCM SAM 5.72207
310 2RGO FAD 5.72207
311 3VSE SAH 5.72207
312 2YG3 FAD 5.72207
313 3GU3 SAH 5.72207
314 1PNF NDG NAG 5.73248
315 3NJ4 NAD 5.74713
316 1KYZ FER 5.75342
317 1KYZ SAH 5.75342
318 3O7W SAM 5.78231
319 1JQD SAH 5.82192
320 1JQD HSM 5.82192
321 5E1M SAH 5.84615
322 5E1M PRO PRO LYS ARG ILE ALA 5.84615
323 3BP1 GUN 5.86207
324 4TQG NDP 5.88235
325 4NTD FAD 5.88235
326 4BJZ P3A 5.89623
327 4BJZ FAD 5.89623
328 3H2B SAH 5.91133
329 3KP6 SAL 5.96026
330 5GWX SAR 5.98592
331 5GWX SAM 5.98592
332 3NDJ SAH 5.99455
333 3NDJ JHZ 5.99455
334 1ZK7 FAD 5.99455
335 2YVF FAD 5.99455
336 2YVF NAD 5.99455
337 5F8F SFG 6
338 1LDN OXM 6.01266
339 3OFK SAH 6.01852
340 2WK1 SAH 6.02837
341 1Q1R FAD 6.03248
342 3FPF TNA 6.04027
343 3FPF MTA 6.04027
344 1IM8 SAI 6.14754
345 2AE2 PTO 6.15385
346 2AE2 NAP 6.15385
347 2EG5 SAH 6.1828
348 2PT9 2MH 6.23053
349 2PT9 S4M 6.23053
350 1OBB NAD 6.26703
351 1L1E SAH 6.27178
352 3RJ5 NAD 6.29921
353 4G5H NAP 6.33609
354 4G5H UD7 6.33609
355 1LSS NAD 6.42857
356 5LOG SAH 6.43777
357 4HSU FAD 6.45161
358 4GUS FAD 6.45161
359 4GUT FAD 6.45161
360 1RJW ETF 6.48968
361 3FZG SAM 6.5
362 4A6D SAM 6.51558
363 5ICE 2H4 6.53409
364 5ICE SAH 6.53409
365 1E5Q NDP 6.53951
366 1RKX NAD 6.72269
367 1SNY NAP 6.74157
368 1SQF SAM 6.75991
369 2C7G FAD 6.81199
370 2C7G ODP 6.81199
371 3QFA FAD 6.89655
372 3TKA SAM 6.91643
373 1ORR NAD 6.91643
374 5ERG SAM 7.04961
375 2I7C AAT 7.06714
376 5GM1 SAH 7.07071
377 4USQ FAD 7.08447
378 5HJM MTA 7.10227
379 3RFV 15L 7.11611
380 3RFV NAI 7.11611
381 5DLY SAH 7.14286
382 5DLY 5D7 7.14286
383 1S7N COA 7.14286
384 3Q87 SAM 7.2
385 3WGT QSC 7.20461
386 3WGT FAD 7.20461
387 4II2 ATP 7.22892
388 2AG5 NAD 7.31707
389 1U1I NAD 7.39796
390 2ZFU SAH 7.44186
391 1S7G APR 7.50988
392 1S7G NAD 7.50988
393 5E72 SAM 7.51445
394 5ZW3 SAH 7.55556
395 4KRG SAH 7.62943
396 4MO2 FDA 7.62943
397 4MO2 FAD 7.62943
398 1GEE NAD 7.66284
399 5JE0 AZ8 7.69231
400 5JE0 SAH 7.69231
401 3KO8 NAD 7.69231
402 2UYQ SAM 7.74194
403 1XHL NDP 7.74411
404 3OID NDP 7.75194
405 1QO8 FAD 7.90191
406 6C5B SAH 7.91789
407 1VE3 SAM 7.92952
408 5T67 JHZ 7.93269
409 5T67 SAH 7.93269
410 5JGL SAM 7.95848
411 1I1N SAH 7.9646
412 2Q0L FAD 8.03859
413 1VDC FAD 8.10811
414 1RLZ NAD 8.13008
415 2WET FAD 8.21918
416 5WUW NAP 8.36237
417 2AQJ TRP 8.36431
418 2AQJ FAD 8.36431
419 2HNK SAH 8.3682
420 3RKR NAP 8.39695
421 5UFN SAH 8.40336
422 1U7T TDT 8.42912
423 1U7T NAD 8.42912
424 4POO SAM 8.5
425 5EEH SAH 8.51064
426 5EEH P9P 8.51064
427 4R6W PC 8.52713
428 4R6W SAH 8.52713
429 1VL0 NAI 8.56164
430 2QA1 FAD 8.6
431 2Q1W NAD 8.70871
432 1XDS SAM 8.71935
433 1QZZ SAM 8.71935
434 4MOP 2H5 8.71935
435 4KGD FAD 8.71935
436 4KGD TDP 8.71935
437 2WTX VDO 8.71935
438 2WTX UDP 8.71935
439 5BSZ SAH 8.8
440 3OA2 NAD 8.80503
441 1UDB NAD 8.87574
442 1UDB UFG 8.87574
443 2YX1 SFG 8.92857
444 1XCL SAH 8.93617
445 5FTW SAH 8.98438
446 2BZG SAH 9.05172
447 3VYW SAM 9.09091
448 5EOW FAD 9.1358
449 4YMH SAH 9.16667
450 6FX2 FUC C4W NAG BMA MAN NAG GAL 9.30233
451 1XG5 NAP 9.319
452 6AIN FAD 9.33014
453 4OBW SAM 9.33852
454 3MCT SAH 9.42761
455 1REO FAD 9.46502
456 1UAY ADN 9.50413
457 4NTC FAD 9.55224
458 3DXY SAM 9.63303
459 2HMT NAI 9.72222
460 1I9G SAM 10
461 2R4J FAD 10
462 2R4J 13P 10
463 1Q0S SAH 10
464 3KLJ FAD 10
465 2E5V FAD 10
466 1PN0 FAD 10
467 1PN0 IPH 10
468 1X87 NAD 10
469 4BLW AMP 10
470 1MO9 FAD 10
471 1MO9 KPC 10
472 4BLW SAH 10
473 1V59 FAD 10.0817
474 1V59 NAD 10.0817
475 3A4V NAD 10.0946
476 3A4V PYR 10.0946
477 5OJ7 AR6 10.1399
478 3EWP APR 10.1695
479 3LCC SAH 10.2128
480 4UA3 COA 10.3093
481 3G2O SAM 10.3679
482 2FWP CIT 10.3825
483 1FP2 SAH 10.5114
484 1FP2 HMO 10.5114
485 1P1C SAH 10.5528
486 2F2T 5IQ 10.559
487 1JA9 NDP 10.5839
488 2CDU FAD 10.6267
489 2CDU ADP 10.6267
490 2PXX SAH 10.6977
491 2Q7V FAD 10.7692
492 3BXO SAM 10.8787
493 5K7U SAM 10.8883
494 4FLP JQ1 10.9244
495 3ITJ FAD 10.9467
496 1QAN SAH 11.0656
497 4QTU SAM 11.1111
498 4ITU 1HS 11.1524
499 4ITU NAI 11.1524
500 1YQC GLV 11.1765
501 3QOX SAH 11.2676
502 3A25 SAM 11.2957
503 5DNK SAH 11.4441
504 4K26 NDP 11.5942
505 4K26 SFF 11.5942
506 3H8V ATP 11.6438
507 3U4C NDP 11.7166
508 1KPH SAH 11.8467
509 1RP0 AHZ 11.9718
510 5IL1 SAM 12
511 5L95 AMP 12.1864
512 3P2E SAH 12.4444
513 4C4A SAH 12.4615
514 3NUG NAD 12.5506
515 5Z2L NDP 12.6531
516 2YVJ FAD 12.844
517 3WV8 ATP 12.844
518 2YVJ NAI 12.844
519 1KPG SAH 12.892
520 4I5I NAD 12.892
521 6HOY AR6 12.9139
522 6HOY TSN 12.9139
523 1ELI PYC 13.1105
524 4KXQ APR 13.3333
525 1A27 NAP 13.3515
526 1XSE NDP 13.5593
527 1R18 SAH 13.6564
528 2XYQ SAH 13.9344
529 1TPY SAH 13.9373
530 6DUB SAH 13.964
531 1Y8Q ATP 14.1618
532 2Z3Y F2N 14.1689
533 5MW4 5JU 14.3713
534 3VZS NAP 14.786
535 3VZS CAA 14.786
536 3HVJ 705 14.9321
537 4KIB SAH 15
538 4M73 SAH 15
539 3PT9 SAH 15
540 4M73 M72 15
541 1ZEM NAD 15
542 4TM3 FAD 15
543 2NXE SAM 15
544 4HXY NDP 15
545 2JB2 FAD 15
546 2JB2 PHE 15
547 3AYI HCI 15
548 3AYI FAD 15
549 1JNR FAD 15
550 1EK6 NAI 15
551 2FR1 NDP 15
552 2DX7 CIT 15
553 4LHD GLY 15
554 1EK6 UPG 15
555 5N5D SAM 15.0442
556 1ZQ9 SAM 15.4386
557 1VL8 NAP 15.7303
558 4PNE SAH 15.894
559 3GRU AMP 15.9322
560 1W73 NAP 16.2252
561 1W8D NAP 16.2252
562 1W6U NAP 16.2252
563 3A27 SAM 16.5441
564 2XVM SAH 17.0854
565 3MB5 SAM 17.2549
566 1EJ0 SAM 18.3333
567 4GLL NAD 18.3976
568 3SJ7 NDP 19.4444
569 1O97 FAD 19.6875
570 1O97 AMP 19.6875
571 1O94 ADP 19.6875
572 3X0D SAH 20
573 1WG8 SAM 20
574 5WP4 SAH 20
575 2VDV SAM 20
576 5MGZ SAH 20
577 3PFG SAM 20
578 3PFG TLO 20
579 3OU2 SAH 20
580 6BQ6 TER 20
581 5WP5 SAH 20
582 3T7S SAM 20
583 1JG3 ADN 20
584 4REP FAD 20
585 4RVG TYD 20
586 4RVG SAM 20
587 3RNM FAD 20
588 2EWM NAD 20
589 1NAA ABL 20
590 1NAA 6FA 20
591 5U8U FAD 20
592 2F5Z FAD 20
593 5J5Z FAD 20
594 3LAD FAD 20
595 4AP3 NAP 20
596 4AP3 FAD 20
597 5I39 FAD 20
598 4EMI NAD 20
599 4EMI FAD 20
600 6ER9 FAD 20
601 6ER9 NAP 20
602 5KMS NAD 20
603 1OC2 TDX 20
604 1OC2 NAD 20
605 1KNR FAD 20
606 5MPT SAH 20
607 5KMS FAD 20
608 4K5S PM0 20
609 4K5S FAD 20
610 4EMJ FAD 20
611 5ODQ FAD 20
612 4J56 FAD 20
613 6D6Y SAH 20
614 2RGJ FAD 20
615 5NA1 FAD 20
616 4M52 FAD 20
617 3CTY FAD 20
618 2Q46 NAP 20
619 3T31 DCQ 20
620 3T31 FAD 20
621 1Z45 NAD 20
622 4O0L NDP 20
623 2A8X FAD 20
624 2DKN NAI 20
625 4M52 M52 20
626 1V5F FAD 20
627 1V5F TPP 20
628 3ABI NAD 20
629 5T2U NAP 20
630 3UBM COA 20
631 5G3L SIA 20.202
632 1L3I SAH 20.3125
633 3O03 NAP 20.9622
634 3HB5 NAP 21.7125
635 4Y30 49L 25
636 4Y30 SAH 25
637 5DXA SFG 25
638 4YUW 4JU 25
639 4YUW S4M 25
640 2WSB NAD 25
641 1BDB NAD 25
642 1Z3C SA8 25
643 2GDZ NAD 25
644 1WY7 SAH 25
645 1XTP SAI 25
646 3ELW SAM 25
647 3EVF SAH 25
648 5JJR SAH 25
649 3EVF GTA 25
650 5YF1 8V0 25
651 3ELW GP3 25
652 3GCZ SAM 25
653 5YF1 SFG 25
654 3S1S SAH 25
655 4YRY FAD 25
656 4YAC NAI 25
657 1G60 SAM 25
658 1UWK NAD 25
659 1UWK URO 25
660 5VN0 NAI 25
661 5E9W SAH 25
662 3GDN HBX 25
663 3GDN FAD 25
664 3FRH SAH 25
665 4YAG NAI 25
666 5EB4 FAD 25
667 5VN0 FAD 25
668 2ZWA SAH 25
669 4ZRN UPG 25
670 5GWT SIN 25
671 1BXK NAD 25
672 4ZRN NAD 25
673 5THY SAH 25
674 5THZ SAH 25
675 5GWT NAD 25
676 4FC7 NAP 25
677 4FC7 COA 25
678 6ECW SAH 25
679 3V1U NAD 25
680 1KEW NAD 25
681 6ECU SAH 25
682 3P9C SAH 25
683 5X7Q GLC GLC GLC GLC 25
684 4DMG SAM 25
685 4AT0 FAD 25
686 5G3U FDA 25
687 4YRY NAD 25
688 5X7Q GLC GLC GLC 25
689 4DSG FAD 25
690 4DSG UDP 25
691 5BRT FAD 25
692 5BRT CH9 25
693 1H5Q NAP 25
694 3M6W SAM 25
695 2RH4 EMO 25
696 5MBX FAD 25
697 5MBX SP5 25
698 3DUW SAH 25
699 4YKG NAD 25
700 4YKG FAD 25
701 5G3U ITW 25
702 6FHO FAD 25
703 1KEW TYD 25
704 1EDO NAP 25
705 2Q28 ADP 25
706 3O26 NDP 25
707 5UAO FAD 25
708 1UZN NAP 25
709 1G8K MGD 25
710 2CUL FAD 25
711 1WMA NDP 25
712 1WMA AB3 25
713 3HQ9 OXL 25
714 1AE1 NAP 25
715 3ML1 MGD 25.9259
716 4XUC SAM 27.9817
717 4XUC 43G 27.9817
718 5E8J SAH 29.5455
719 4KRI SAH 30
720 2PWY SAH 30
721 3GEG NAD 30
722 5ULP KB1 30
723 3ZV6 4HB 30
724 3ZV6 NAD 30
725 4IWN GEK 30
726 3EVG SAH 30
727 2P41 SAH 30
728 3LKZ SFG 30
729 1GPE FAD 30
730 3L9W AMP 30
731 1XHC FAD 30
732 3L9W GSH 30
733 1Q9I FAD 30
734 1Q9I TEO 30
735 1ZBQ NAD 30
736 4CQM NAP 30
737 6F5Z SAH 30
738 4URF NAD 30
739 4JNA FAD 30
740 1EFV FAD 30
741 3VC1 GST 30
742 3VC1 SAH 30
743 1EFV AMP 30
744 4IV9 FAD 30
745 1ZGA SAH 30
746 3IHG FAD 30
747 3K7M FAD 30
748 6F9Q NAD 30
749 3SJU NDP 30
750 5JCA NDP 30
751 5JCA FAD 30
752 3QJ4 FAD 30
753 3OZ2 FAD 30
754 2PX8 SAH 30
755 5DF1 58X 30
756 5DF1 NAP 30
757 4ZA2 NAD 30
758 5XWV NDP 30
759 4L2I FAD 30
760 2NYA MGD 30
761 2C31 ADP 30
762 2C31 TZD 30
763 3EYA FAD 30
764 1YKJ FAD 30
765 1YKJ PHB 30
766 4UP3 FAD 30
767 4D5G FAD 30
768 5XWV 8H6 30
769 4D5G TPP 30
770 4LWP SAH 35
771 1GZ6 NAI 35
772 4B63 NAP 35
773 4B63 FAD 35
774 4B63 ORN 35
775 4HA6 FAD 35
776 6ECT SAM 35
777 5JCM NAD 35
778 5JCM ISD 35
779 5JCM FAD 35
780 1D4D FAD 35
781 4X9M FAD 35
782 1E6E FAD 35
783 5EJ2 NAD 35
784 5N0J FAD 35
785 4D04 FAD 35
786 4D04 NAP 35
787 4JDR FAD 35
788 1E1M NAP 35
789 1E1M FAD 35
790 5KOX RFP 35
791 5KOX FAD 35
792 3I53 SAH 35
793 4MIG G3F 35
794 4Z24 FAD 35
795 1E6W NAD 35
796 1PR9 NAP 35
797 2Y6Q FAD 35
798 2Y6Q I7T 35
799 1GTE FAD 35
800 2PZM NAD 35
801 2PZM UDP 35
802 3D3W NAP 35
803 2BD0 NAP 35
804 5J7X FAD 35
805 4NBT NAD 35
806 1E3W NAD 35
807 2V6G NAP 35
808 3W9F I3P 35
809 6EL3 NAP 35
810 3QXV MTX 35
811 2B4Q NAP 35
812 2JBM SRT 35
813 3U31 NAD 35
814 1F3L SAH 36.1371
815 4M37 SAH 40
816 4FN4 NAD 40
817 3QVP FAD 40
818 1GEG NAD 40
819 1COY FAD 40
820 1IY8 NAD 40
821 4D7E FAD 40
822 5ZYN FAD 40
823 3UCL FAD 40
824 3UCL NAP 40
825 3UCL CYH 40
826 5J60 FAD 40
827 4C3Y ANB 40
828 4C3Y FAD 40
829 2WPF FAD 40
830 1BZL GCG 40
831 2WPF WPF 40
832 4YSX FAD 40
833 1BZL FAD 40
834 4U8P FDA 40
835 4U8P UDP 40
836 5OVK NDP 40
837 5OVL NAP 40
838 3DMH GMP 45
839 3C6K SPD 45
840 3DMH SAM 45
841 3C6K MTA 45
842 5HSA FAS 45
843 1N2X SAM 45
844 3AD8 NAD 45
845 2GAG FAD 45
846 2GAG NAD 45
847 3AD8 FAD 45
848 3AD8 PYC 45
849 2GAG FOA 45
850 5FEU NAP 45
851 1NFQ NAI 45
852 1PS9 FAD 45
853 1FEC FAD 45
854 3CH6 NAP 45
855 3CH6 311 45
856 6CI9 NAP 45
857 5CUQ NSC 50
858 3ICT FAD 50
859 3ICS FAD 50
860 3ICR FAD 50
861 4ZCC FAD 50
862 4ZCC NAI 50
863 1G0N PHH 50
864 1G0N NDP 50
Pocket No.: 2; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: 4
This union binding pocket(no: 2) in the query (biounit: 5fa5.bio3) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 2D3Y DU 3.19635
2 1SQS TLA 12.3967
3 5YB7 ORN 30
4 5YB7 FAD 30
Pocket No.: 3; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 5fa5.bio3) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: 1
This union binding pocket(no: 4) in the query (biounit: 5fa5.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 1NSA BEN 3.79747
Pocket No.: 5; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 5fa5.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 5fa5.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 5fa5.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: 3
This union binding pocket(no: 8) in the query (biounit: 5fa5.bio2) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 2HIM ASP 12.2905
2 6FP4 FAD 25
3 6FP4 E1T 25
Pocket No.: 9; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 5fa5.bio2) has 19 residues
No: Leader PDB Ligand Sequence Similarity
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