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Showing PDB: 5FPA

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Receptor | Ligand | View in 3D

Family: 90% | 70% | 50% | site

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      Structure Biounit | Ligand Information

PDB           : .ZIP | .CSV

Family 90% : .ZIP | .CSV

Class         : .ZIP | .CSV

Receptor

PDB id	Resolution	Class	Description	Source	Keywords
5FPA	1.96 Å	EC: 1.14.11.-	CRYSTAL STRUCTURE OF HUMAN KDM4D IN COMPLEX WITH 3H,4H- PYRIDO-3,4-D-PYRIMIDIN-4-ONE	HOMO SAPIENS	OXIDOREDUCTASE OXIDOREDUCATSE INHIBITOR LYSINE SPECIFIC HDEMETHYLASE JMJD2D KDM4D JUMONJI
Ref.:	CELL PENETRANT INHIBITORS OF THE KDM4 AND KDM5 FAMI HISTONE LYSINE DEMETHYLASES. 1. 3-AMINO-4-PYRIDINE CARBOXYLATE DERIVATIVES. J.MED.CHEM. V. 59 1357 2016

Ligand

Ligand	Chain:Residue	Validity	Ligand Warnings	Binding Data	NGL Viewer	Molecular Weight (Da)	Formula	SMILES
SO4	A:1346; A:1344; A:1345; A:1349; A:1347; A:1348; A:1343;	Invalid; Invalid; Invalid; Invalid; Invalid; Invalid; Invalid;	none; none; none; none; none; none; none;	submit data		96.063	O4 S	[O-]S...
CO	A:360;	Part of Protein;	none;	submit data		58.933	Co	[Co+2...
ZN	A:350;	Part of Protein;	none;	submit data		65.409	Zn	[Zn+2...
N5J	A:1342;	Valid;	none;	submit data		147.134	C7 H5 N3 O	c1cnc...

View in 3D viewer

90% Homology Family

Leader

PDB id	Resolution	Class	Description	Source	Keywords
5FP4	2 Å	EC: 1.14.11.-	CRYSTAL STRUCTURE OF HUMAN KDM4D IN COMPLEX WITH 3-(4- PHENYLBUTANAMIDO)PYRIDINE-4-CARBOXYLIC ACID	HOMO SAPIENS	TRANSCRIPTION INHIBITOR LYSINE SPECIFIC HISTONE DEMETHYLASJMJD2D KDM4D JUMONJI
Ref.:	CELL PENETRANT INHIBITORS OF THE KDM4 AND KDM5 FAMI HISTONE LYSINE DEMETHYLASES. 1. 3-AMINO-4-PYRIDINE CARBOXYLATE DERIVATIVES. J.MED.CHEM. V. 59 1357 2016

Members (9)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 43 families.
1	5FP4	ic50 = 0.251 uM	YC8	C16 H16 N2 O3	c1ccc(cc1)....
2	5FP7	-	YC8	C16 H16 N2 O3	c1ccc(cc1)....
3	5F5C	-	5V3	C15 H14 N4 O	c1ccc(cc1)....
4	5FP8	-	AUY	C12 H12 N2 O2 S	Cc1cc(sc1)....
5	5F5A	-	5V0	C12 H12 N2 O3	c1cc(oc1)C....
6	5FP9	ic50 = 1.585 uM	4SV	C6 H6 N2 O2	c1cncc(c1C....
7	5FPA	-	N5J	C7 H5 N3 O	c1cncc2c1C....
8	5FPB	-	HA6	C10 H7 N5 O2	c1cncc2c1C....
9	4HON	-	THR ALA ARG M3L SER THR GLY GLY LYS ALA	n/a	n/a

70% Homology Family (49)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 31 families.
1	6H4T	Ki = 0.004 uM	FOW	C25 H26 N6 O	c1ccc2c(c1....
2	5A7P	-	6Z1	C17 H13 N3 O5	Cc1cc(no1)....
3	5ANQ	ic50 = 3.98 uM	5YQ	C16 H13 N5 O2	c1cc(cnc1)....
4	6H4Q	ic50 = 2.06 uM	FO2	C16 H18 N6 O	CN1CCC(CC1....
5	2OQ6	-	OGA	C4 H5 N O5	C(C(=O)O)N....
6	2OX0	-	OGA	C4 H5 N O5	C(C(=O)O)N....
7	6H4S	Ki = 0.002 uM	FQE	C27 H33 N7 O	CN(C)CCc1c....
8	5F3G	ic50 = 0.126 uM	5UL	C24 H25 Cl N6 O	c1cc(ccc1C....
9	5A7Q	-	KCH	C12 H10 N2 O3	c1cc(c(cc1....
10	6H4P	Ki = 0.003 uM	FQ5	C23 H23 Cl N6 O	c1cc(cc(c1....
11	5A7N	-	VAO	C13 H8 N2 O3	c1cc(c(cc1....
12	5F3E	ic50 = 0.138 uM	5UO	C23 H23 Cl N6 O	c1cc(ccc1C....
13	2GP5	-	AKG	C5 H6 O5	C(CC(=O)O)....
14	6H4V	ic50 = 0.613 uM	FQN	C20 H24 N6 O	c1cnc(c2c1....
15	6H4O	ic50 = 0.128 uM	FQH	C24 H23 F3 N6 O	c1cc(cc(c1....
16	2OT7	-	OGA	C4 H5 N O5	C(C(=O)O)N....
17	6H4U	-	FO2	C16 H18 N6 O	CN1CCC(CC1....
18	5A7S	-	S2X	C14 H12 N2 O4	CC(=O)Nc1c....
19	6H4R	Ki = 0.004 nM	FQB	C27 H33 N7 O	CN(C)CCc1c....
20	4AI9	-	DZA	C6 H12 N2 O3	CN(C)NC(=O....
21	3U4S	Ki = 114 nM	ALA ARG M3L SER CYS GLY GLY LYS 08P	n/a	n/a
22	3PDQ	ic50 = 0.18 uM	KC6	C14 H14 N4 O3	c1cnc(cc1C....
23	5F3C	ic50 = 0.9 uM	5U8	C20 H19 F N6 O	CN(CCc1cnn....
24	5F32	ic50 = 11.5 uM	5V7	C10 H7 N5 O S	c1cnc(c2c1....
25	4URA	ic50 = 0.00000316 uM	LEL	C8 H6 N4 O2	c1cnc(cc1C....
26	5F2S	ic50 = 0.2 uM	5TZ	C9 H7 N3 O2 S	c1cnc(cc1C....
27	2YBK	ic50 = 24 uM	2HG	C5 H8 O5	C(CC(=O)O)....
28	5TVR	-	AKG	C5 H6 O5	C(CC(=O)O)....
29	5A80	-	9CJ	C21 H18 N2 O5	COc1cccc(c....
30	6H4Y	ic50 = 0.077 uM	FO8	C29 H35 N7 O2	c1cc(ccc1C....
31	5A7O	-	7WH	C15 H14 N2 O5	COCC(=O)Nc....
32	6CG1	-	QC1	C13 H11 F N2 O2	c1cc(ccc1C....
33	5F37	ic50 = 1.7 uM	N5J	C7 H5 N3 O	c1cncc2c1C....
34	6H4X	ic50 = 0.131 uM	FNQ	C28 H27 N7 O	c1cc(cnc1)....
35	6CG2	-	QC2	C15 H11 N3 O3	c1cc(cc(c1....
36	2OQ7	-	OGA	C4 H5 N O5	C(C(=O)O)N....
37	5FPV	-	MMK	C15 H22 N4 O3	CCN(/C=C/N....
38	5F3I	ic50 = 0.08 uM	5UJ	C23 H22 Cl2 N6 O	c1cnc(c2c1....
39	5KR7	ic50 = 2.88 uM	6X9	C11 H12 N4 O	CCC1=C(Nc2....
40	4XDO	ic50 = 84 uM	OGA	C4 H5 N O5	C(C(=O)O)N....
41	5FP4	ic50 = 0.251 uM	YC8	C16 H16 N2 O3	c1ccc(cc1)....
42	5FP7	-	YC8	C16 H16 N2 O3	c1ccc(cc1)....
43	5F5C	-	5V3	C15 H14 N4 O	c1ccc(cc1)....
44	5FP8	-	AUY	C12 H12 N2 O2 S	Cc1cc(sc1)....
45	5F5A	-	5V0	C12 H12 N2 O3	c1cc(oc1)C....
46	5FP9	ic50 = 1.585 uM	4SV	C6 H6 N2 O2	c1cncc(c1C....
47	5FPA	-	N5J	C7 H5 N3 O	c1cncc2c1C....
48	5FPB	-	HA6	C10 H7 N5 O2	c1cncc2c1C....
49	4HON	-	THR ALA ARG M3L SER THR GLY GLY LYS ALA	n/a	n/a

50% Homology Family (50)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 28 families.
1	6H4T	Ki = 0.004 uM	FOW	C25 H26 N6 O	c1ccc2c(c1....
2	5A7P	-	6Z1	C17 H13 N3 O5	Cc1cc(no1)....
3	5ANQ	ic50 = 3.98 uM	5YQ	C16 H13 N5 O2	c1cc(cnc1)....
4	6H4Q	ic50 = 2.06 uM	FO2	C16 H18 N6 O	CN1CCC(CC1....
5	2OQ6	-	OGA	C4 H5 N O5	C(C(=O)O)N....
6	2OX0	-	OGA	C4 H5 N O5	C(C(=O)O)N....
7	6H4S	Ki = 0.002 uM	FQE	C27 H33 N7 O	CN(C)CCc1c....
8	5F3G	ic50 = 0.126 uM	5UL	C24 H25 Cl N6 O	c1cc(ccc1C....
9	5A7Q	-	KCH	C12 H10 N2 O3	c1cc(c(cc1....
10	6H4P	Ki = 0.003 uM	FQ5	C23 H23 Cl N6 O	c1cc(cc(c1....
11	5A7N	-	VAO	C13 H8 N2 O3	c1cc(c(cc1....
12	5F3E	ic50 = 0.138 uM	5UO	C23 H23 Cl N6 O	c1cc(ccc1C....
13	2GP5	-	AKG	C5 H6 O5	C(CC(=O)O)....
14	6H4V	ic50 = 0.613 uM	FQN	C20 H24 N6 O	c1cnc(c2c1....
15	6H4O	ic50 = 0.128 uM	FQH	C24 H23 F3 N6 O	c1cc(cc(c1....
16	2OT7	-	OGA	C4 H5 N O5	C(C(=O)O)N....
17	6H4U	-	FO2	C16 H18 N6 O	CN1CCC(CC1....
18	5A7S	-	S2X	C14 H12 N2 O4	CC(=O)Nc1c....
19	6H4R	Ki = 0.004 nM	FQB	C27 H33 N7 O	CN(C)CCc1c....
20	4AI9	-	DZA	C6 H12 N2 O3	CN(C)NC(=O....
21	3U4S	Ki = 114 nM	ALA ARG M3L SER CYS GLY GLY LYS 08P	n/a	n/a
22	3PDQ	ic50 = 0.18 uM	KC6	C14 H14 N4 O3	c1cnc(cc1C....
23	5F3C	ic50 = 0.9 uM	5U8	C20 H19 F N6 O	CN(CCc1cnn....
24	5F32	ic50 = 11.5 uM	5V7	C10 H7 N5 O S	c1cnc(c2c1....
25	4URA	ic50 = 0.00000316 uM	LEL	C8 H6 N4 O2	c1cnc(cc1C....
26	5F2S	ic50 = 0.2 uM	5TZ	C9 H7 N3 O2 S	c1cnc(cc1C....
27	2YBK	ic50 = 24 uM	2HG	C5 H8 O5	C(CC(=O)O)....
28	5TVR	-	AKG	C5 H6 O5	C(CC(=O)O)....
29	5A80	-	9CJ	C21 H18 N2 O5	COc1cccc(c....
30	6H4Y	ic50 = 0.077 uM	FO8	C29 H35 N7 O2	c1cc(ccc1C....
31	5A7O	-	7WH	C15 H14 N2 O5	COCC(=O)Nc....
32	6CG1	-	QC1	C13 H11 F N2 O2	c1cc(ccc1C....
33	5F37	ic50 = 1.7 uM	N5J	C7 H5 N3 O	c1cncc2c1C....
34	6H4X	ic50 = 0.131 uM	FNQ	C28 H27 N7 O	c1cc(cnc1)....
35	6CG2	-	QC2	C15 H11 N3 O3	c1cc(cc(c1....
36	2OQ7	-	OGA	C4 H5 N O5	C(C(=O)O)N....
37	5FPV	-	MMK	C15 H22 N4 O3	CCN(/C=C/N....
38	5F3I	ic50 = 0.08 uM	5UJ	C23 H22 Cl2 N6 O	c1cnc(c2c1....
39	3OPT	-	AKG	C5 H6 O5	C(CC(=O)O)....
40	5KR7	ic50 = 2.88 uM	6X9	C11 H12 N4 O	CCC1=C(Nc2....
41	4XDO	ic50 = 84 uM	OGA	C4 H5 N O5	C(C(=O)O)N....
42	5FP4	ic50 = 0.251 uM	YC8	C16 H16 N2 O3	c1ccc(cc1)....
43	5FP7	-	YC8	C16 H16 N2 O3	c1ccc(cc1)....
44	5F5C	-	5V3	C15 H14 N4 O	c1ccc(cc1)....
45	5FP8	-	AUY	C12 H12 N2 O2 S	Cc1cc(sc1)....
46	5F5A	-	5V0	C12 H12 N2 O3	c1cc(oc1)C....
47	5FP9	ic50 = 1.585 uM	4SV	C6 H6 N2 O2	c1cncc(c1C....
48	5FPA	-	N5J	C7 H5 N3 O	c1cncc2c1C....
49	5FPB	-	HA6	C10 H7 N5 O2	c1cncc2c1C....
50	4HON	-	THR ALA ARG M3L SER THR GLY GLY LYS ALA	n/a	n/a

Polypharmacology

Similar Ligands (2D)

Ligand no: 1; Ligand: N5J; Similar ligands found: 1

No:	Ligand	ECFP6 Tc	MDL keys Tc
1	N5J	1	1

Similar Ligands (3D)

Ligand no: 1; Ligand: N5J; Similar ligands found: 1153

No:	Ligand	Similarity coefficient
1	1LQ	1.0000
2	1SQ	1.0000
3	JBH	1.0000
4	JPZ	1.0000
5	ES1	1.0000
6	5SG	1.0000
7	4YS	1.0000
8	1LM	1.0000
9	HQY	1.0000
10	1NP	1.0000
11	5IQ	1.0000
12	5Q0	1.0000
13	O72	1.0000
14	24W	0.9989
15	HH8	0.9913
16	4XH	0.9913
17	SWD	0.9886
18	ADE	0.9830
19	1XN	0.9828
20	SVN	0.9827
21	Q88	0.9823
22	BTE	0.9822
23	HPA	0.9819
24	ISN	0.9800
25	6MP	0.9797
26	KKN	0.9792
27	10L	0.9788
28	GLC	0.9788
29	BP1	0.9786
30	9DA	0.9784
31	ES0	0.9781
32	9HX	0.9779
33	NPY	0.9778
34	R8V	0.9776
35	QUZ	0.9770
36	F05	0.9769
37	12Q	0.9769
38	5WV	0.9768
39	7WA	0.9763
40	6M9	0.9760
41	9EW	0.9758
42	BGC	0.9758
43	7HP	0.9756
44	A7W	0.9755
45	SAL	0.9754
46	CWM	0.9752
47	AZ8	0.9750
48	ES7	0.9749
49	7W4	0.9747
50	3WA	0.9746
51	M0W	0.9729
52	HLZ	0.9728
53	6M4	0.9726
54	0P6	0.9725
55	KJH	0.9724
56	JBQ	0.9724
57	0RW	0.9721
58	XYP	0.9719
59	MT0	0.9718
60	ADZ	0.9715
61	ES4	0.9715
62	PM6	0.9714
63	9DG	0.9714
64	AZA	0.9712
65	TTL	0.9711
66	495	0.9707
67	7HQ	0.9703
68	HLR	0.9702
69	JBE	0.9701
70	GUN	0.9699
71	M1A	0.9697
72	HQT	0.9696
73	67N	0.9694
74	32X	0.9693
75	Q24	0.9693
76	5RG	0.9691
77	PE0	0.9690
78	CFP	0.9690
79	CWS	0.9688
80	KUF	0.9688
81	M6N	0.9687
82	I3A	0.9680
83	M1Q	0.9678
84	LXC	0.9676
85	7W1	0.9675
86	IGA	0.9673
87	XAN	0.9673
88	8CM	0.9669
89	5QX	0.9667
90	HZQ	0.9665
91	25W	0.9663
92	PXL	0.9662
93	7B4	0.9660
94	3HA	0.9660
95	UNC	0.9660
96	DIN	0.9659
97	23A	0.9657
98	KT7	0.9654
99	M0Q	0.9654
100	1PT	0.9654
101	2D0	0.9653
102	MEW	0.9648
103	G6D	0.9646
104	DHQ	0.9645
105	AJ2	0.9640
106	MRW	0.9638
107	M1H	0.9635
108	7VS	0.9634
109	3M0	0.9634
110	EQT	0.9632
111	4HC	0.9632
112	AQO	0.9631
113	A2F	0.9631
114	M5K	0.9627
115	6AP	0.9619
116	3ID	0.9616
117	4CS	0.9616
118	2CK	0.9614
119	DEN	0.9613
120	SKA	0.9613
121	URC	0.9607
122	290	0.9606
123	AZ9	0.9602
124	GIO	0.9601
125	G3F	0.9601
126	141	0.9600
127	3U4	0.9597
128	JBK	0.9596
129	1P7	0.9594
130	3F0	0.9589
131	FOT	0.9589
132	AHR	0.9588
133	BE2	0.9587
134	9MG	0.9587
135	BHO	0.9586
136	DX4	0.9581
137	ES6	0.9581
138	DBJ	0.9580
139	DBH	0.9574
140	JKE	0.9574
141	AZG	0.9573
142	J9W	0.9569
143	4SV	0.9566
144	8GC	0.9564
145	M1E	0.9562
146	HJP	0.9562
147	GTQ	0.9561
148	0W8	0.9556
149	SWA	0.9554
150	FE DB1	0.9551
151	5M0	0.9551
152	8S0	0.9551
153	EA1	0.9549
154	5WX	0.9549
155	XXR	0.9544
156	1WD	0.9543
157	GAB	0.9542
158	OXC	0.9541
159	6CS	0.9537
160	4NC	0.9536
161	BOA	0.9535
162	GCS	0.9533
163	BZF	0.9532
164	4JP	0.9531
165	3PF	0.9531
166	3Z8	0.9530
167	NMJ	0.9529
168	BCP	0.9528
169	7NI	0.9525
170	3HB	0.9525
171	DMD	0.9522
172	3NT	0.9521
173	XQ0	0.9520
174	DHB	0.9518
175	ADK	0.9517
176	BZI	0.9516
177	JUG	0.9515
178	ORO	0.9514
179	3IT	0.9512
180	YH7	0.9511
181	IND	0.9510
182	7WV	0.9507
183	8TX	0.9506
184	Q6T	0.9505
185	39A	0.9504
186	APZ	0.9503
187	1XM	0.9502
188	5HN	0.9498
189	F5B	0.9496
190	5NU	0.9496
191	XM0	0.9495
192	AX7	0.9494
193	LSA	0.9494
194	BDP	0.9494
195	IJZ	0.9493
196	BEZ	0.9489
197	54G	0.9488
198	G3E	0.9487
199	GVH	0.9486
200	BZX	0.9484
201	270	0.9483
202	COU	0.9480
203	LZ1	0.9478
204	HH5	0.9478
205	BTY	0.9475
206	3AB	0.9473
207	FA0	0.9472
208	IDM	0.9470
209	0R1	0.9468
210	75K	0.9468
211	ABV	0.9467
212	03V	0.9467
213	GAL	0.9466
214	MPI	0.9465
215	VNL	0.9464
216	AKH	0.9463
217	42C	0.9458
218	5B1	0.9458
219	ISE	0.9455
220	B60	0.9453
221	5CU	0.9453
222	YCP	0.9453
223	0CT	0.9452
224	H42	0.9452
225	HQD	0.9451
226	GRE	0.9449
227	XYS	0.9448
228	53C	0.9446
229	F60	0.9445
230	6AI	0.9444
231	JB5	0.9443
232	86J	0.9443
233	14O	0.9442
234	2ZV	0.9441
235	HHA	0.9440
236	MUA	0.9438
237	6PC	0.9438
238	2K4	0.9437
239	SOE	0.9436
240	5H1	0.9435
241	2AQ	0.9434
242	1WG	0.9433
243	NQ	0.9433
244	B55	0.9432
245	GYE	0.9432
246	CTL	0.9431
247	5QY	0.9431
248	G1O	0.9429
249	LZM	0.9429
250	QBK	0.9429
251	42A	0.9428
252	6M1	0.9426
253	OCH	0.9425
254	4FS	0.9425
255	34D	0.9424
256	0N7	0.9424
257	FDB	0.9423
258	0CU	0.9423
259	ES5	0.9422
260	RXA	0.9419
261	6F0	0.9418
262	MAQ	0.9416
263	P9P	0.9414
264	OVV	0.9413
265	2MI	0.9412
266	LT2	0.9412
267	D1X	0.9412
268	9TZ	0.9411
269	DHK	0.9411
270	5MB	0.9410
271	G5V	0.9408
272	5RN	0.9408
273	5JQ	0.9407
274	C2U	0.9406
275	DOB	0.9404
276	DOR	0.9404
277	VK3	0.9403
278	DRL	0.9403
279	8IG	0.9401
280	NBZ	0.9400
281	XX2	0.9399
282	RSF	0.9399
283	AW5	0.9397
284	NIO	0.9397
285	GDE	0.9397
286	92K	0.9396
287	150	0.9396
288	5MI	0.9395
289	INO	0.9394
290	2HQ	0.9393
291	XAZ	0.9392
292	BHA	0.9392
293	NOJ	0.9391
294	5MK	0.9390
295	3MA	0.9390
296	YSO	0.9390
297	4M0	0.9389
298	MYJ	0.9388
299	BEN	0.9388
300	0FO	0.9386
301	P92	0.9385
302	4AA	0.9385
303	SX1	0.9384
304	NCA	0.9383
305	MO8	0.9381
306	173	0.9380
307	NTM	0.9379
308	BAM	0.9379
309	URF	0.9373
310	2CQ	0.9372
311	ASO	0.9371
312	SE2	0.9370
313	0TR	0.9370
314	7ZE	0.9369
315	XQG	0.9368
316	AJV	0.9367
317	4A3	0.9367
318	NNO	0.9366
319	IV2	0.9366
320	TEP	0.9364
321	WCE	0.9363
322	12B	0.9362
323	D48	0.9362
324	ARB	0.9362
325	JZ9	0.9360
326	RAM	0.9360
327	B62	0.9359
328	GAG	0.9355
329	VNJ	0.9355
330	QWN	0.9354
331	J5I	0.9353
332	XHP	0.9351
333	PYQ	0.9351
334	4XR	0.9351
335	FHB	0.9350
336	3BZ	0.9349
337	PZA	0.9347
338	EXO	0.9347
339	WBU	0.9345
340	2ZQ	0.9343
341	VGL	0.9341
342	4MU	0.9341
343	GBD	0.9339
344	BRT	0.9339
345	JAE	0.9338
346	MCT	0.9338
347	2HO	0.9336
348	OXQ	0.9336
349	MWM	0.9335
350	PHT	0.9333
351	0MK	0.9333
352	3HM	0.9327
353	ES9	0.9327
354	FK1	0.9327
355	44W	0.9326
356	93K	0.9325
357	B53	0.9325
358	FUL	0.9325
359	5WY	0.9322
360	NDH	0.9320
361	BE7	0.9319
362	BEA	0.9318
363	GCU	0.9318
364	4ZE	0.9316
365	11S	0.9313
366	UNU	0.9312
367	6GU	0.9311
368	H4N	0.9310
369	JIF	0.9309
370	FYU	0.9308
371	HY3	0.9308
372	OTW	0.9307
373	TOF	0.9304
374	TDR	0.9302
375	DQU	0.9302
376	CHB	0.9302
377	F0J	0.9300
378	E7Z	0.9300
379	P3K	0.9300
380	MWP	0.9299
381	2EC	0.9299
382	CFF	0.9299
383	1DW	0.9297
384	QX4	0.9297
385	5OB	0.9296
386	7CZ	0.9295
387	S76	0.9295
388	2AC	0.9293
389	A1U	0.9291
390	2AK	0.9290
391	PZI	0.9289
392	5JL	0.9288
393	15L	0.9285
394	9KT	0.9285
395	4HO	0.9281
396	NK	0.9280
397	B57	0.9280
398	KYD	0.9280
399	SXS	0.9279
400	DIE	0.9278
401	9TW	0.9276
402	2YU	0.9276
403	2MP	0.9272
404	5AC	0.9270
405	QSB	0.9270
406	LGC	0.9270
407	8NY	0.9268
408	XBZ	0.9268
409	8WT	0.9268
410	NTN	0.9267
411	4ME	0.9265
412	D07	0.9264
413	MBD	0.9263
414	34A	0.9260
415	1MC	0.9259
416	4JT	0.9257
417	3RK	0.9257
418	3MB	0.9255
419	CTS	0.9255
420	SS1	0.9255
421	HMH	0.9254
422	SKM	0.9254
423	OVM	0.9253
424	2FG	0.9253
425	PYD	0.9250
426	ICP	0.9250
427	RM1	0.9250
428	V55	0.9250
429	NDM	0.9249
430	XYD	0.9249
431	TH7	0.9249
432	43M	0.9249
433	INS	0.9249
434	1P3	0.9248
435	2H5	0.9248
436	GTR	0.9248
437	149	0.9248
438	PFB	0.9247
439	NPO	0.9245
440	ICO	0.9244
441	KLW	0.9243
442	TM7	0.9243
443	37T	0.9240
444	JZ3	0.9240
445	HFB	0.9236
446	MVN	0.9235
447	4M4	0.9235
448	DIU	0.9233
449	KJY	0.9233
450	PYG	0.9233
451	TH0	0.9232
452	KIB	0.9231
453	44V	0.9230
454	QXW	0.9230
455	SYV	0.9230
456	NID	0.9228
457	3OC	0.9227
458	HT4	0.9223
459	ET2	0.9223
460	2A7	0.9222
461	CLW	0.9221
462	2AL	0.9221
463	60P	0.9220
464	5UC	0.9220
465	QWW	0.9218
466	36R	0.9217
467	RIP	0.9216
468	HIS	0.9216
469	EKZ	0.9215
470	3Z7	0.9213
471	INE	0.9213
472	G2F	0.9212
473	4CL	0.9211
474	1P8	0.9211
475	AC0	0.9210
476	PBC	0.9207
477	3MC	0.9207
478	FLM	0.9206
479	0JD	0.9205
480	SHG	0.9205
481	MZG	0.9203
482	DFB	0.9203
483	J9T	0.9198
484	KOJ	0.9198
485	6ME	0.9197
486	M58	0.9195
487	GJS	0.9195
488	3FA	0.9195
489	4ZC	0.9194
490	51R	0.9193
491	GLA	0.9193
492	A13	0.9192
493	82I	0.9192
494	RM4	0.9192
495	4Z4	0.9191
496	ES2	0.9191
497	7VJ	0.9189
498	FUC	0.9188
499	GMN	0.9187
500	QX2	0.9186
501	JXN	0.9185
502	DUB	0.9183
503	QSH	0.9183
504	7MH	0.9182
505	4JJ	0.9181
506	GM7	0.9180
507	45C	0.9179
508	ZVO	0.9175
509	QPR	0.9174
510	KJU	0.9173
511	FBB	0.9172
512	3SK	0.9171
513	DBX	0.9171
514	L3Q	0.9170
515	HMU	0.9170
516	3ZQ	0.9169
517	FGZ	0.9167
518	IHB	0.9167
519	UAN	0.9165
520	FBV	0.9164
521	Z82	0.9164
522	JZ2	0.9163
523	PHB	0.9162
524	NIZ	0.9162
525	NOY	0.9161
526	IFM	0.9155
527	F31	0.9155
528	VGD	0.9154
529	FBT	0.9153
530	N8Y	0.9153
531	IFL	0.9153
532	5JC	0.9152
533	0FN	0.9152
534	QSC	0.9150
535	5MH	0.9150
536	MQN	0.9149
537	2C9	0.9149
538	329	0.9146
539	SHA	0.9146
540	K2T	0.9145
541	DPZ	0.9145
542	FFP	0.9145
543	6MH	0.9143
544	27Y	0.9142
545	SRO	0.9140
546	FCB	0.9139
547	MFB	0.9138
548	ZZT	0.9137
549	CFI	0.9136
550	QAT	0.9135
551	DNF	0.9135
552	24B	0.9135
553	NTZ	0.9135
554	6VD	0.9134
555	KBG	0.9134
556	3DM	0.9133
557	F4Z	0.9132
558	K5W	0.9131
559	FCA	0.9130
560	2CM	0.9130
561	GOG	0.9128
562	EYK	0.9128
563	PXM	0.9128
564	EVA	0.9128
565	6RQ	0.9127
566	BR9	0.9127
567	RMN	0.9126
568	LKA	0.9126
569	LI6	0.9124
570	5RO	0.9124
571	UEG	0.9123
572	FAN	0.9122
573	5VM	0.9122
574	3DO	0.9122
575	2MY	0.9121
576	7ME	0.9120
577	ARA	0.9120
578	3MG	0.9120
579	TIU	0.9119
580	JND	0.9118
581	JA8	0.9118
582	4JQ	0.9117
583	T6C	0.9117
584	3FH	0.9117
585	OAA	0.9117
586	PAB	0.9115
587	PA1	0.9115
588	IFP	0.9114
589	ISZ	0.9114
590	MWJ	0.9114
591	BZ3	0.9114
592	SJ5	0.9113
593	GZ8	0.9111
594	X05	0.9110
595	WOO	0.9110
596	MAN	0.9108
597	X09	0.9107
598	YQA	0.9107
599	BCF	0.9106
600	J1Z	0.9106
601	2DR	0.9106
602	A29	0.9105
603	7B3	0.9102
604	64K	0.9102
605	TC7	0.9101
606	ASC	0.9101
607	4JO	0.9098
608	TTY	0.9098
609	R9Y	0.9097
610	23J	0.9093
611	GIV	0.9093
612	M2K	0.9092
613	35C	0.9091
614	4YO	0.9090
615	680	0.9089
616	JFD	0.9086
617	39O	0.9085
618	1Y6	0.9085
619	QAS	0.9085
620	12M	0.9085
621	RNS	0.9085
622	97T	0.9084
623	AZF	0.9082
624	J9Q	0.9080
625	286	0.9079
626	BBF	0.9078
627	CLZ	0.9075
628	PRF	0.9075
629	DQN	0.9074
630	G4D	0.9074
631	ALL	0.9074
632	0TU	0.9072
633	275	0.9071
634	3CE	0.9070
635	GCB	0.9070
636	3XX	0.9070
637	GOO	0.9068
638	PCI	0.9067
639	KBB	0.9066
640	HBD	0.9062
641	5GU	0.9060
642	1GN	0.9058
643	FB1	0.9057
644	DFU	0.9057
645	IT2	0.9056
646	BR8	0.9055
647	XCZ	0.9052
648	MS9	0.9051
649	5XC	0.9050
650	826	0.9050
651	IPB	0.9050
652	QOS	0.9050
653	EUG	0.9049
654	TM4	0.9049
655	8H8	0.9049
656	YIO	0.9049
657	SOR	0.9048
658	F81	0.9047
659	NSP	0.9047
660	TLD	0.9046
661	URQ	0.9046
662	8OZ	0.9045
663	X0V	0.9043
664	9FL	0.9043
665	PHH	0.9042
666	2FQ	0.9042
667	I1N	0.9042
668	HNQ	0.9040
669	GAF	0.9040
670	LDP	0.9039
671	8WO	0.9038
672	0R0	0.9037
673	XIY	0.9036
674	Q7A	0.9035
675	1KP	0.9034
676	40O	0.9034
677	209	0.9032
678	BK9	0.9030
679	F12	0.9030
680	4MA	0.9029
681	PBZ	0.9029
682	282	0.9029
683	IUR	0.9028
684	LCN	0.9028
685	4HM	0.9025
686	X6X	0.9024
687	OW4	0.9023
688	BMA	0.9021
689	PQ0	0.9020
690	5CL	0.9019
691	261	0.9019
692	RSO	0.9019
693	HX3	0.9017
694	FBW	0.9016
695	FPK	0.9016
696	PDC	0.9016
697	R8A	0.9015
698	H33	0.9013
699	OXE	0.9013
700	MBG	0.9013
701	7WR	0.9012
702	4TU	0.9011
703	JXW	0.9011
704	ADA	0.9010
705	Y8I	0.9008
706	OMD	0.9008
707	ASP	0.9008
708	DGJ	0.9006
709	Z5P	0.9004
710	OXZ	0.9004
711	GZL	0.9004
712	R8S	0.9003
713	CAQ	0.9001
714	IBF	0.9000
715	MLT	0.8999
716	AFR	0.8996
717	CN0	0.8996
718	1M2	0.8995
719	RIB	0.8992
720	FPI	0.8991
721	RPQ	0.8990
722	AX2	0.8987
723	6UA	0.8986
724	KFH	0.8985
725	F3B	0.8984
726	13X	0.8983
727	174	0.8981
728	RHU	0.8981
729	15E	0.8980
730	Q71	0.8979
731	ZZ3	0.8977
732	4P5	0.8975
733	4XV	0.8973
734	3MH	0.8970
735	2FY	0.8968
736	FPY	0.8967
737	5NE	0.8966
738	GXL	0.8966
739	FBU	0.8965
740	SYN	0.8960
741	20J	0.8960
742	AJY	0.8959
743	HBX	0.8958
744	8ZE	0.8958
745	ODO	0.8958
746	FUF	0.8957
747	2MN	0.8956
748	URA	0.8956
749	FP1	0.8954
750	MR1	0.8954
751	PAF	0.8954
752	ENL	0.8951
753	AMC	0.8951
754	UFV	0.8948
755	3R6	0.8945
756	8XQ	0.8945
757	B5D	0.8945
758	HBA	0.8944
759	VOH	0.8944
760	XXP	0.8944
761	7MU	0.8942
762	AC6	0.8942
763	OA3	0.8941
764	YTB	0.8940
765	PRO	0.8939
766	0LH	0.8938
767	IF7	0.8938
768	PBA	0.8937
769	4FH	0.8936
770	GXY	0.8936
771	IDH	0.8936
772	NK2	0.8935
773	QIC	0.8934
774	4SX	0.8934
775	0HO	0.8933
776	5AN	0.8933
777	L89	0.8933
778	KIA	0.8932
779	RCO	0.8932
780	EJZ	0.8931
781	94N	0.8931
782	AIN	0.8931
783	WOT	0.8930
784	2AF	0.8930
785	717	0.8929
786	PYF	0.8928
787	PX7	0.8928
788	SVD	0.8927
789	3AY	0.8926
790	9CA	0.8925
791	MVL	0.8924
792	284	0.8924
793	GVG	0.8924
794	WDL	0.8923
795	I6G	0.8922
796	L99	0.8922
797	F9P	0.8921
798	IPZ	0.8920
799	PHU	0.8918
800	ERH	0.8917
801	3NY	0.8917
802	TBP	0.8916
803	069	0.8916
804	PEY	0.8916
805	2PC	0.8916
806	MZB	0.8916
807	K17	0.8914
808	SYA	0.8914
809	GLF	0.8913
810	BEW	0.8913
811	5ZE	0.8911
812	92Z	0.8911
813	FBM	0.8910
814	HIO	0.8909
815	PY7	0.8909
816	UFO	0.8907
817	BSP	0.8906
818	OVP	0.8906
819	ABN	0.8905
820	LG3	0.8904
821	2BG	0.8902
822	ABE	0.8900
823	TSS	0.8900
824	FOA	0.8900
825	HA7	0.8899
826	FP2	0.8898
827	8W9	0.8896
828	FLV	0.8896
829	MNM	0.8895
830	LYL	0.8894
831	APG	0.8894
832	54D	0.8893
833	SRT	0.8893
834	FB2	0.8893
835	226	0.8893
836	1IT	0.8892
837	TBS	0.8892
838	HXX	0.8892
839	6NT	0.8892
840	GV9	0.8892
841	1U6	0.8892
842	8LG	0.8891
843	92P	0.8890
844	C21	0.8890
845	DMJ	0.8890
846	1AN	0.8890
847	PAC	0.8889
848	CRS	0.8889
849	K34	0.8886
850	FBG	0.8884
851	FDK	0.8884
852	2CH	0.8884
853	0HN	0.8882
854	CYT	0.8882
855	4XS	0.8881
856	3CH	0.8881
857	SMV	0.8881
858	GLY PRO	0.8881
859	HQJ	0.8880
860	JZ5	0.8880
861	MSN	0.8880
862	265	0.8876
863	DEE	0.8873
864	2ZM	0.8873
865	PYC	0.8873
866	94B	0.8872
867	N8P	0.8872
868	FA3	0.8872
869	95Z	0.8872
870	JTH	0.8872
871	ZWZ	0.8870
872	LMR	0.8870
873	EV0	0.8869
874	2A9	0.8869
875	TWO	0.8869
876	47J	0.8868
877	26D	0.8868
878	MJ2	0.8867
879	TLA	0.8866
880	JZ0	0.8865
881	TGX	0.8865
882	PRZ	0.8865
883	NEQ	0.8865
884	2LP	0.8864
885	TAR	0.8864
886	GOX	0.8864
887	LG5	0.8862
888	C2Y	0.8861
889	76X	0.8861
890	9R5	0.8861
891	9TY	0.8860
892	GIF	0.8856
893	0F9	0.8856
894	PMB	0.8852
895	ZB1	0.8852
896	2LY	0.8851
897	M5N	0.8851
898	3C1	0.8850
899	2ZX	0.8847
900	93Q	0.8846
901	TP5	0.8846
902	P72	0.8843
903	AEZ	0.8843
904	52C	0.8843
905	GCO	0.8843
906	ZZ8	0.8840
907	BVF	0.8840
908	VXX	0.8839
909	FCR	0.8838
910	AUD	0.8838
911	2HU	0.8837
912	AS3	0.8835
913	BDF	0.8835
914	6KX	0.8834
915	PHE	0.8834
916	FA1	0.8833
917	FRU	0.8833
918	TPA	0.8832
919	C2A	0.8831
920	KIV	0.8831
921	HHR	0.8830
922	4PW	0.8830
923	6LW	0.8827
924	MAK	0.8826
925	PH2	0.8823
926	X8D	0.8822
927	SW7	0.8818
928	E3D	0.8817
929	DYA	0.8817
930	HTS	0.8816
931	JZ1	0.8815
932	JG8	0.8814
933	06B	0.8814
934	GIM	0.8814
935	TZC	0.8814
936	RB5	0.8814
937	F9Y	0.8813
938	9RW	0.8813
939	AGK	0.8812
940	7N0	0.8811
941	XYL	0.8810
942	3C2	0.8810
943	FH2	0.8809
944	N2I	0.8809
945	NVU	0.8809
946	MT5	0.8808
947	938	0.8808
948	4VP	0.8808
949	2PG	0.8808
950	ZYR	0.8807
951	GLT	0.8806
952	HKD	0.8806
953	BNS	0.8805
954	MHK	0.8805
955	ABI	0.8803
956	260	0.8800
957	948	0.8799
958	JBN	0.8799
959	HTP	0.8798
960	5NI	0.8795
961	BCU	0.8791
962	8GF	0.8790
963	TSU	0.8790
964	EDR	0.8788
965	BPU	0.8788
966	JYB	0.8787
967	IP0	0.8786
968	JU2	0.8786
969	3SL	0.8786
970	FDR	0.8785
971	G12	0.8785
972	K6X	0.8785
973	XUL	0.8785
974	SF9	0.8784
975	TFU	0.8784
976	AAS	0.8781
977	JAB	0.8780
978	1F1	0.8780
979	L7T	0.8779
980	1XX	0.8779
981	XBT	0.8777
982	4P0	0.8774
983	JLZ	0.8774
984	KPL	0.8773
985	2XX	0.8771
986	1MR	0.8770
987	091	0.8770
988	273	0.8769
989	N7P	0.8767
990	23W	0.8766
991	CGB	0.8765
992	28N	0.8765
993	KGK	0.8764
994	FLC	0.8764
995	DX3	0.8763
996	6OT	0.8760
997	YAN	0.8760
998	L5V	0.8759
999	8GK	0.8759
1000	6HQ	0.8758
1001	18N	0.8757
1002	285	0.8757
1003	ECE	0.8757
1004	6X8	0.8756
1005	CWJ	0.8754
1006	KDV	0.8754
1007	PBE	0.8752
1008	DHS	0.8750
1009	NCD	0.8750
1010	ROI	0.8749
1011	JXZ	0.8748
1012	B3R	0.8745
1013	JKZ	0.8744
1014	ZXD	0.8744
1015	3A9	0.8743
1016	K32	0.8742
1017	14J	0.8741
1018	3AL	0.8740
1019	4WL	0.8740
1020	DUC	0.8740
1021	1X7	0.8739
1022	NCT	0.8739
1023	OK7	0.8738
1024	6BL	0.8737
1025	DNC	0.8737
1026	Q77	0.8737
1027	NGO	0.8734
1028	HGQ	0.8734
1029	7D2	0.8733
1030	SMN	0.8733
1031	URP	0.8727
1032	6NI	0.8726
1033	II6	0.8726
1034	LNR	0.8724
1035	H3M	0.8724
1036	FQI	0.8723
1037	GCV	0.8721
1038	MRZ	0.8720
1039	TT4	0.8717
1040	CIG	0.8714
1041	MXN	0.8713
1042	2F6	0.8712
1043	PD2	0.8711
1044	1DU	0.8711
1045	CXF	0.8711
1046	K22	0.8709
1047	1AL	0.8707
1048	HPY	0.8706
1049	15N	0.8706
1050	ONR	0.8705
1051	4H2	0.8705
1052	SAN	0.8705
1053	JAW	0.8704
1054	2KA	0.8704
1055	PLQ	0.8703
1056	M3T	0.8702
1057	ZZZ	0.8701
1058	AMG	0.8701
1059	BNT	0.8699
1060	D3M	0.8698
1061	HEW	0.8694
1062	LRH	0.8690
1063	TZE	0.8690
1064	ESI	0.8690
1065	4ZA	0.8686
1066	FPN	0.8686
1067	PCA	0.8685
1068	0XT	0.8684
1069	YHO	0.8684
1070	ZBT	0.8683
1071	BZ2	0.8683
1072	1LN	0.8682
1073	O2A	0.8681
1074	TCZ	0.8679
1075	0W1	0.8678
1076	LDR	0.8678
1077	H8N	0.8673
1078	MFU	0.8672
1079	EOL	0.8672
1080	GTZ	0.8670
1081	DA1	0.8668
1082	GCW	0.8667
1083	K8X	0.8667
1084	PFL	0.8667
1085	94W	0.8666
1086	HQE	0.8663
1087	LG4	0.8661
1088	ASN	0.8657
1089	XXG	0.8656
1090	5NS	0.8653
1091	H76	0.8651
1092	9PY	0.8650
1093	PIM	0.8649
1094	PCR	0.8648
1095	PKU	0.8644
1096	EN1	0.8644
1097	8G0	0.8643
1098	GT0	0.8642
1099	HLD	0.8637
1100	F1A	0.8634
1101	E7S	0.8631
1102	FBA	0.8630
1103	HA5	0.8628
1104	1DQ	0.8628
1105	2TQ	0.8626
1106	0FK	0.8624
1107	H62	0.8623
1108	AH8	0.8622
1109	SS2	0.8621
1110	ICC	0.8619
1111	DHR	0.8618
1112	1DV	0.8618
1113	X0W	0.8612
1114	R9S	0.8612
1115	CRN	0.8612
1116	DQA	0.8612
1117	1XA	0.8612
1118	280	0.8611
1119	9FE	0.8610
1120	0GZ	0.8610
1121	4J8	0.8607
1122	XSP	0.8606
1123	8HC	0.8603
1124	PXY	0.8603
1125	H7Y	0.8602
1126	9AP	0.8601
1127	AY4	0.8601
1128	PEP	0.8598
1129	HHQ	0.8594
1130	TMT	0.8593
1131	MMA	0.8592
1132	4CH	0.8592
1133	PEL	0.8591
1134	QMP	0.8590
1135	FBS	0.8588
1136	8NX	0.8587
1137	TMZ	0.8586
1138	25R	0.8586
1139	4JM	0.8583
1140	4TE	0.8577
1141	A09	0.8576
1142	XX3	0.8575
1143	R2B	0.8565
1144	JZ4	0.8563
1145	259	0.8560
1146	M4E	0.8550
1147	RAT	0.8549
1148	RUU	0.8548
1149	QY9	0.8540
1150	FHN	0.8533
1151	AEF	0.8533
1152	3TJ	0.8531
1153	PBR	0.8523

Similar Binding Sites (Proteins are less than 50% similar to leader)

Pocket No.: 1; Query (leader) PDB : 5FP4; Ligand: YC8; Similar sites found with APoc: 1

This union binding pocket(no: 1) in the query (biounit: 5fp4.bio1) has 23 residues
No:	Leader PDB	Ligand	Sequence Similarity
1	6IP0	AKG	43.7126

Pocket No.: 2; Query (leader) PDB : 5FP4; Ligand: YC8; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.

This union binding pocket(no: 2) in the query (biounit: 5fp4.bio1) has 23 residues
No:	Leader PDB	Ligand	Sequence Similarity

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