-->
Receptor
PDB id Resolution Class Description Source Keywords
5FPX 1.5 Å NON-ENZYME: OTHER THE STRUCTURE OF KDGF FROM YERSINIA ENTEROCOLITICA. YERSINIA ENTEROCOLITICA HYDROLASE KDGF PECTIN ALGINATE URONATE SUGAR METABOLISM
Ref.: KDGF, THE MISSING LINK IN THE MICROBIAL METABOLISM URONATE SUGARS FROM PECTIN AND ALGINATE. PROC.NATL.ACAD.SCI.USA V. 113 6188 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NI A:1105;
B:1105;
Part of Protein;
Part of Protein;
none;
none;
submit data
58.693 Ni [Ni+2...
GLY SER SER HIS HIS HIS HIS HIS E:1;
F:1;
Valid;
Valid;
Atoms found LESS than expected: % Diff = 0;
Atoms found LESS than expected: % Diff = 0;
submit data
782.8 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5FPX 1.5 Å NON-ENZYME: OTHER THE STRUCTURE OF KDGF FROM YERSINIA ENTEROCOLITICA. YERSINIA ENTEROCOLITICA HYDROLASE KDGF PECTIN ALGINATE URONATE SUGAR METABOLISM
Ref.: KDGF, THE MISSING LINK IN THE MICROBIAL METABOLISM URONATE SUGARS FROM PECTIN AND ALGINATE. PROC.NATL.ACAD.SCI.USA V. 113 6188 2016
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 5FPZ - MLA C3 H4 O4 C(C(=O)O)C....
2 5FPX - GLY SER SER HIS HIS HIS HIS HIS n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 5FPZ - MLA C3 H4 O4 C(C(=O)O)C....
2 5FPX - GLY SER SER HIS HIS HIS HIS HIS n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 5FPZ - MLA C3 H4 O4 C(C(=O)O)C....
2 5FPX - GLY SER SER HIS HIS HIS HIS HIS n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLY SER SER HIS HIS HIS HIS HIS; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY SER SER HIS HIS HIS HIS HIS 1 1
2 GLY HIS GLY 0.533333 0.823529
3 HIS HIS HIS HIS HIS GLY SER 0.517241 0.941176
4 GLY ALA ARG ALA HIS SER SER 0.466667 0.790323
5 ASP SER GLY PHE SER PHE GLY SER LYS 0.464286 0.754717
6 ALA HIS ALA 0.4625 0.698113
7 HIS HIS HIS HIS HIS HIS 0.451219 0.769231
8 PHE ASN GLU LEU SER HIS LEU 0.44 0.824561
9 LYS SER HIS GLN GLU 0.432692 0.872727
10 ALA HIS HIS 0.432099 0.754717
11 SER HIS MET ALA GLU ILE 0.431579 0.779661
12 GLY HIS ARG PRO NH2 0.428571 0.661538
13 LYS GLY GLY ALA ALY ARG HIS ARG LYS VAL 0.428571 0.68254
14 ACE LEU HIS SER TPO ALA NH2 0.419048 0.723077
15 LYS HIS LYS 0.411111 0.763636
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5FPX; Ligand: GLY SER SER HIS HIS HIS HIS HIS; Similar sites found with APoc: 378
This union binding pocket(no: 1) in the query (biounit: 5fpx.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 3ZXE PGZ None
2 1IS3 LAT None
3 5NFB 8VT None
4 1C1L GAL BGC None
5 6D61 4AA None
6 5H9P TD2 None
7 1N5S ADL None
8 4IMO PWZ None
9 4M1U A2G MBG None
10 1QY1 PRZ None
11 5H9Q TD2 None
12 6EOZ 58K None
13 4RFR RHN None
14 4PSB GA3 None
15 4HSJ 6PC None
16 6FOF LAT None
17 5AIG VPR None
18 1OGX EQU None
19 5NLD LBT None
20 3L5R 47X None
21 1TT8 PHB None
22 3QP8 HL0 None
23 4EE7 PIS None
24 5ODY 9SK None
25 2YNE NHW None
26 2YNE YNE None
27 6CC0 EWM None
28 2A4W BLM None
29 1I06 TZL None
30 5NCF 8T5 None
31 3E2M E2M None
32 3STK PLM None
33 2HO2 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU None
34 3TCT 3MI None
35 5VGS 9A4 None
36 6EOZ AKG None
37 1DY4 SNP None
38 2X34 UQ8 None
39 2X32 OTP None
40 1ERB ETR None
41 2D6M LBT 1.76991
42 5XEG AKG 1.76991
43 5F3I 5UJ 1.76991
44 2VQ5 LDP 1.76991
45 1DZK PRZ 1.76991
46 2VQ5 HBA 1.76991
47 2OS2 OGA 1.76991
48 2Q8E OGA 1.76991
49 5FWE OGA 1.76991
50 5LY2 OGA 1.76991
51 1OGZ EQU 1.76991
52 2YBP 2HG 1.76991
53 3M3E GAL A2G NPO 1.76991
54 2P5B OGA 1.76991
55 1SDW IYT 1.76991
56 5J3Z 6FQ 1.76991
57 5UC4 83S 1.76991
58 5BVE 4VG 2.21607
59 3NV3 GAL NAG MAN 2.65487
60 2ET1 GLV 2.65487
61 1LRH NLA 2.65487
62 4ZU4 4TG 2.65487
63 4BXF AKG 2.65487
64 6FE1 V14 2.65487
65 5KR7 6X9 2.65487
66 1LN1 DLP 2.65487
67 2GJ5 VD3 2.65487
68 1U0A BGC BGC BGC BGC 2.65487
69 5TZO 7V7 2.65487
70 5IH9 6BF 2.65487
71 1T3D CYS 2.65487
72 5LXB 7A9 2.65487
73 2P7Q GG6 2.65487
74 1KJ1 MAN 2.75229
75 1CEB AMH 3.40909
76 3SCH TB6 3.53982
77 1ZZ7 S0H 3.53982
78 6BU0 IHP 3.53982
79 4Y3O OGA 3.53982
80 4CCN OGA 3.53982
81 2FCU AKG 3.53982
82 1Y9Q MED 3.53982
83 4CCK OGA 3.53982
84 4CCO OGA 3.53982
85 3VQ2 LP4 LP5 MYR DAO 3.53982
86 1UNB PN1 3.53982
87 4FFG 0U8 3.53982
88 4RLT FSE 3.53982
89 1OJK GLC BGC 3.53982
90 1OJJ GLC GAL 3.53982
91 3SAO NKN 3.53982
92 4O9S 2RY 3.53982
93 2I74 MAN MAN MAN MAN 3.53982
94 3SAO DBH 3.53982
95 4COQ SAN 3.53982
96 4FFG LBS 3.53982
97 1UNB AKG 3.53982
98 5YXC CIT 3.53982
99 2IF8 ADP 3.53982
100 5HMR FDZ 3.53982
101 5HV0 AKG 4.42478
102 3HQR OGA 4.42478
103 4JZR 4JR 4.42478
104 4YLZ LAT NAG GAL 4.42478
105 5ML3 DL3 4.42478
106 2XMY CDK 4.42478
107 2V95 HCY 4.42478
108 5OX6 A1Z 4.42478
109 2CDO GAL AAL GAL AAL GAL AAL 4.42478
110 3VHH VHH 4.42478
111 2JLD AG1 4.42478
112 3G08 FEE 4.42478
113 3N0Y APC 4.42478
114 3NKT 1HN 4.42478
115 4G31 0WH 4.42478
116 5WL1 D3D 4.42478
117 6FA4 D1W 4.42478
118 6C1S EFV 4.42478
119 3PQB VGP 4.42478
120 5OCG 9R5 4.42478
121 4W9N TCL 4.42478
122 4QDC ASD 4.42478
123 5B09 4MX 4.80769
124 5Y4K AKR 5.30973
125 1WW5 SGA BGC 5.30973
126 1I82 BGC BGC 5.30973
127 3WG3 A2G GAL NAG FUC 5.30973
128 4QM9 CYS 5.30973
129 1DMY AZM 5.30973
130 5OO5 UUA 5.30973
131 5FWJ MMK 5.30973
132 4QXB OGA 5.30973
133 6EWZ APC 5.30973
134 5UWA 8ND 5.30973
135 4JH6 FCN 5.30973
136 5ZM4 9FU 5.30973
137 5ZM4 AKG 5.30973
138 4D1J DGJ 5.30973
139 4IPH 1FJ 5.30973
140 4P7X AKG 5.30973
141 4P7X YCP 5.30973
142 1OS7 AKG 5.30973
143 1PN0 IPH 5.30973
144 1P0Z FLC 5.30973
145 5I0U DCY 6.19469
146 5JWP AKG 6.19469
147 1H2K OGA 6.19469
148 2XUM OGA 6.19469
149 3P3N AKG 6.19469
150 2Y0I AKG 6.19469
151 4B7E OGA 6.19469
152 6F6D AKG 6.19469
153 5O9W AKG 6.19469
154 5T7I LAT NAG GAL 6.19469
155 2WA4 069 6.19469
156 5C3R HMU 6.19469
157 5C3R AKG 6.19469
158 3WUC GLC GAL 6.19469
159 3MPB FRU 6.19469
160 5FP3 3JI 6.19469
161 6B9R 2HE 6.19469
162 1OIJ AKG 6.19469
163 5U98 1KX 6.19469
164 5DRB 5FJ 6.19469
165 2WSA MYA 6.19469
166 2WSA 646 6.19469
167 1H2M OGA 6.19469
168 5E2N V14 6.19469
169 1OIK AKG 6.19469
170 5N87 N66 6.19469
171 1UMZ BGC BGC XYS BGC XYS GAL 6.19469
172 1ZM1 BGC BGC BGC 6.19469
173 1S4M LUM 6.19469
174 1MHC FME TYR PHE ILE ASN ILE LEU THR LEU 6.19469
175 4YZC STU 6.19469
176 1UU6 BGC BGC BGC BGC 6.19469
177 3ZDS HMQ 6.19469
178 2GWH PCI 6.19469
179 1OLM VTQ 6.19469
180 5XQW 8EU 6.19469
181 4UWJ MYA 6.19469
182 4UWJ 7L5 6.19469
183 3ZDS HQ9 6.19469
184 4CSD MFU 6.19469
185 1NKI PPF 6.66667
186 6F7X MFU 6.66667
187 6F4T OGA 7.07965
188 1ULE GLA GAL NAG 7.07965
189 6GR0 F8W 7.07965
190 5FP4 YC8 7.07965
191 4YGF AZM 7.07965
192 3OPT AKG 7.07965
193 3FW4 CAQ 7.07965
194 1YKD CMP 7.07965
195 5A3T MMK 7.07965
196 2R0H CTO 7.07965
197 3HDY GDU 7.07965
198 4M26 AKG 7.07965
199 4G7A AZM 7.07965
200 4WGF HX2 7.07965
201 1LSH PLD 7.07965
202 4FHD 0TT 7.07965
203 4FHD EEM 7.07965
204 4BVA T3 7.07965
205 5INJ 6C7 7.07965
206 4X5S AZM 7.07965
207 2BS5 BGC GAL FUC 7.77778
208 5JSP DQY 7.9646
209 3WV6 GAL BGC 7.9646
210 5GLT BGC GAL NAG GAL 7.9646
211 3WV6 GAL GLC 7.9646
212 6GNO XDI 7.9646
213 6FXR AKG 7.9646
214 3AVR OGA 7.9646
215 4OCT AKG 7.9646
216 2JIG PD2 7.9646
217 2E56 MYR 7.9646
218 2ZHL NAG GAL GAL NAG 7.9646
219 6FUL E7Z 7.9646
220 4XCB AKG 7.9646
221 1GP6 DH2 7.9646
222 1GP6 SIN 7.9646
223 4XCB HY0 7.9646
224 1GP6 QUE 7.9646
225 1OFZ FUC 7.9646
226 1Y2F WAI 7.9646
227 4ZXA H8N 7.9646
228 3KV4 OGA 7.9646
229 3RWP ABQ 7.9646
230 3FW9 SLX 7.9646
231 5XS3 VAL ARG SER ARG ARG CYS LEU ARG LEU 7.9646
232 3LVW GSH 7.9646
233 6G0X RAM GLC GLA NAG NDG NAG 7.9646
234 3B00 16A 7.9646
235 5K21 6QF 7.9646
236 5EOB 5QQ 7.9646
237 1ZNY GDP 7.9646
238 6EHH 2GE 7.9646
239 3ZW2 GAL FUC 8.04598
240 3ZW2 NAG GAL FUC 8.04598
241 3ZW0 FUC 8.04598
242 1SLT NDG GAL 8.84956
243 4OPC PGT 8.84956
244 3FW3 ETS 8.84956
245 4OPC FDA 8.84956
246 5EW9 5VC 8.84956
247 4D4U FUC GAL NAG 8.84956
248 1WUB OTP 8.84956
249 4WW8 VD9 8.84956
250 1KGI T4A 8.84956
251 1I7E IBS 8.84956
252 4NV7 COA 8.84956
253 1BHX ASP PHE GLU GLU ILE 8.84956
254 4ZSI 4R1 8.84956
255 5KJW 53C 8.84956
256 4D4U FUC NDG GAL FUC 8.84956
257 4ZSI GLP 8.84956
258 2WOX NDP 8.84956
259 3AMN CBK 8.84956
260 3AMN CBI 8.84956
261 4D52 GXL 8.84956
262 4D52 GIV 8.84956
263 2YMZ LAT 9.73451
264 4WUP 3UF 9.73451
265 4NPL AKG 9.73451
266 5MZI FAD 9.73451
267 5MZI FYK 9.73451
268 1MH5 HAL 9.73451
269 1GT4 UNA 9.73451
270 4F7E 0SH 9.73451
271 4GN8 ASO 9.73451
272 4HN1 TYD 9.73451
273 1MJJ HAL 9.73451
274 4WOE ADP 10.6195
275 4Y24 TD2 10.6195
276 3OYW TDG 10.6195
277 3JU6 ANP 10.6195
278 1GZW GAL BGC 10.6195
279 1W6P NDG GAL 10.6195
280 1W6O LAT 10.6195
281 3E8N VRA 10.6195
282 3E8N ATP 10.6195
283 2VFT SOR 10.6195
284 5NCJ SIN 10.6195
285 1LFO OLA 10.6195
286 2NNQ T4B 10.6195
287 1DRY AKG 10.6195
288 1DRY AAG 10.6195
289 3A16 PXO 10.6195
290 1QFT HSM 10.6195
291 5TFZ 7BC 11.5044
292 2IUW AKG 11.5044
293 2ARC ARA 11.5044
294 5YBL AKG 11.5044
295 3N9P OGA 11.5044
296 3N9Q OGA 11.5044
297 6FLZ MMA 11.5044
298 3N9O OGA 11.5044
299 3PUR 2HG 11.5044
300 4PFC 2QX 11.5044
301 5Y72 DST 11.5044
302 3OZ2 OZ2 11.5044
303 2R5V HHH 11.5044
304 5DG2 GAL GLC 12.3894
305 3WUD GLC GAL 12.3894
306 2GC0 PAN 12.3894
307 5U55 S0H 12.3894
308 1T27 PCW 12.3894
309 4QCK ASD 12.3894
310 5A61 3PO 12.3894
311 3ILR SGN 12.3894
312 3ILR IXD 12.3894
313 1SZ0 M6P 12.3894
314 4OJ8 AKG 12.3894
315 5C5T AKG 13.2743
316 1J3R 6PG 13.2743
317 4LIT AKG 13.2743
318 6MPT C30 13.2743
319 4J36 1HR 13.2743
320 3RGA LSB 13.2743
321 1ZB6 GST 13.2743
322 1ZB6 DIN 13.2743
323 3SCM LGN 13.2743
324 1Y0G 8PP 13.2743
325 5NEA 8V8 13.2743
326 4H69 10Y 13.2743
327 6F4W FMC 13.2743
328 4J36 FAD 13.2743
329 3RUG DB6 13.2743
330 2Z77 HE7 14.1593
331 4L4J NAG NAG BMA MAN NAG 14.1593
332 5X7Q ACR 14.1593
333 1JNR FAD 14.1593
334 5X7Q GLC GLC GLC GLC 14.1593
335 5X7Q GLC GLC GLC GLC GLC 14.1593
336 3MKN DNB 14.1593
337 5TPV TYD 14.3791
338 2AG4 LP3 15.0442
339 1QIN GIP 15.0442
340 2AG4 OLA 15.0442
341 6F5W KG1 15.0442
342 5XVG 8FX 15.0442
343 3WW2 LPK 15.9292
344 3WW2 SF6 15.9292
345 4WVW SLT 15.9292
346 5VNF VAL THR SER VAL VAL 15.9292
347 4BG1 OGA 15.9292
348 4BG1 IVL 15.9292
349 1ZHX HC3 15.9292
350 4OIT MAN 15.9292
351 1NYW DAU 16.8142
352 4WO4 JLS 16.8142
353 3PFG TLO 16.8142
354 3PFG SAM 16.8142
355 2XK9 XK9 16.8142
356 3QUZ QUV 17.6991
357 3SHR CMP 17.6991
358 2RDQ AKG 17.6991
359 4IE6 UN9 18.5841
360 4HK8 XYP XYP XYP XYP XYP XYP 18.5841
361 4Q0P 0MK 19.469
362 2AGC DAO 19.469
363 5NBP BGC BGC BGC 19.469
364 6B9T 2HE 21.2389
365 3A7R LAQ 21.2389
366 3HPY MCT 21.2389
367 4L9Z COA 21.2389
368 1GQG DCD 22.1239
369 5LDQ NAP 22.1239
370 1AUA BOG 22.1239
371 5FKP 6UL 22.7273
372 1A78 TDG 25.6637
373 4YVN EBS 25.6637
374 5IVE 6E8 26.5487
375 5NW7 9C2 27.4336
376 5FLJ QUE 30.0885
377 1ODM ASV 31.8584
378 3NW7 LGV 38.0531
APoc FAQ
Feedback