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Showing PDB: 5FZJ

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Receptor | Ligand | View in 3D

Family: 90% | 70% | 50% | site

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      Structure Biounit | Ligand Information

PDB           : .ZIP | .CSV

Family 90% : .ZIP | .CSV

Class         : .ZIP | .CSV

Receptor

PDB id	Resolution	Class	Description	Source	Keywords
5FZJ	2.01 Å	NON-ENZYME: OTHER	STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL INHIBITOR.	MUS MUSCULUS	TRANSCRIPTION KEAP1 NRF2 OXIDATIVE STRESS
Ref.:	MONO-ACIDIC INHIBITORS OF THE KELCH-LIKE ECH-ASSOCI PROTEIN 1 : NUCLEAR FACTOR ERYTHROID 2-RELATED FACT (KEAP1:NRF2) PROTEIN-PROTEIN INTERACTION WITH HIGH POTENCY IDENTIFIED BY FRAGMENT-BASED DISCOVERY. J.MED.CHEM. V. 59 3991 2016

Ligand

Ligand	Chain:Residue	Validity	Ligand Warnings	Binding Data	NGL Viewer	Molecular Weight (Da)	Formula	SMILES
75K	A:1614;	Valid;	none;	submit data		165.146	C8 H7 N O3	Cc1nc...

View in 3D viewer

90% Homology Family

Leader

PDB id	Resolution	Class	Description	Source	Keywords
5FNU	1.78 Å	NON-ENZYME: OTHER	STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL INHIBITOR.	MUS MUSCULUS	TRANSCRIPTION KEAP1 NRF2 OXIDATIVE STRESS
Ref.:	MONO-ACIDIC INHIBITORS OF THE KELCH-LIKE ECH-ASSOCI PROTEIN 1 : NUCLEAR FACTOR ERYTHROID 2-RELATED FACT (KEAP1:NRF2) PROTEIN-PROTEIN INTERACTION WITH HIGH POTENCY IDENTIFIED BY FRAGMENT-BASED DISCOVERY. J.MED.CHEM. V. 59 3991 2016

Members (29)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 1610 families.
1	6T7Z	ic50 = 55 nM	ACY MV5 ASA 4FB GLU THR GLY GLU	n/a	n/a
2	5FNT	Kd = 0.67 uM	0PL	C24 H23 Cl N4 O4 S	Cn1c2ccc(c....
3	4L7C	ic50 = 7.4 uM	1VW	C26 H26 N6 O3	c1ccc2c(c1....
4	5FNU	Kd = 0.0013 uM	L6I	C28 H30 N4 O6 S	Cc1ccc(cc1....
5	7C60	Kd = 27 nM	NF3	C6 H8 O4	CCOC(=O)/C....
6	4ZY3	-	K67	C29 H30 N2 O7 S2	CCOc1ccc(c....
7	7C5E	Kd = 8.4 nM	FUM	C4 H4 O4	C(=C/C(=O)....
8	5FZJ	-	75K	C8 H7 N O3	Cc1nc2c(o1....
9	6Z6A	Kd = 3.7 uM	Q9E	C23 H30 N4 O6 S	CC(=O)N1CC....
10	3ZGC	-	GLY ASP GLU GLU THR GLY GLU	n/a	n/a
11	5FNR	Kd = 59 uM	XMS	C16 H14 Cl N3 O2	Cn1c2ccc(c....
12	6QMC	-	J6H	C14 H12 Cl N O3	c1cc(ccc1[....
13	5FNS	Kd = 4 uM	XYY	C19 H21 Cl N4 O4 S	Cn1c2ccc(c....
14	1X2R	Ka = 5510000 M^-1	LEU ASP GLU GLU THR GLY GLU PHE LEU	n/a	n/a
15	6QMD	ic50 = 170 uM	J6N	C16 H14 Cl N3 O2	Cn1c2ccc(c....
16	6LRZ	Kd = 10 nM	EOU	C6 H8 O4	COC(=O)/C=....
17	6UF0	ic50 = 230 nM	Q5Y	C26 H24 N2 O8 S2	COc1ccc(cc....
18	6V6Z	ic50 = 63 nM	Q5Y	C26 H24 N2 O8 S2	COc1ccc(cc....
19	5FNQ	-	S0W	C9 H9 Cl O2	c1cc(ccc1C....
20	6TYP	Kd = 2.7 nM	PKG	C28 H28 N4 O3	CCn1c2ccc(....
21	6QME	ic50 = 44 uM	J6Q	C17 H16 Cl N3 O2	Cc1cc(ccc1....
22	4L7D	ic50 = 0.75 uM	1VX	C27 H30 N2 O4	Cc1cccc2c1....
23	6TYM	Kd = 13.5 nM	08A	C29 H30 N4 O3	CCn1c2ccc(....
24	5FZN	-	FB2	C6 H7 N O2 S	c1ccc(cc1)....
25	5X54	Kd = 10 uM	ACE GLU TRP TRP TRP	n/a	n/a
26	6QMJ	ic50 = 0.069 uM	J6K	C26 H28 N4 O5 S	Cc1ccc(cc1....
27	4L7B	ic50 = 2.3 uM	1VV	C26 H26 N2 O5	c1ccc2c(c1....
28	4IQK	ic50 = 2.7 uM	IQK	C24 H22 N2 O6 S2	COc1ccc(cc....
29	4XMB	Kd = 44 nM	41P	C28 H28 N4 O8 S2	COc1ccc(cc....

70% Homology Family (31)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 1331 families.
1	6T7Z	ic50 = 55 nM	ACY MV5 ASA 4FB GLU THR GLY GLU	n/a	n/a
2	5FNT	Kd = 0.67 uM	0PL	C24 H23 Cl N4 O4 S	Cn1c2ccc(c....
3	4L7C	ic50 = 7.4 uM	1VW	C26 H26 N6 O3	c1ccc2c(c1....
4	5FNU	Kd = 0.0013 uM	L6I	C28 H30 N4 O6 S	Cc1ccc(cc1....
5	7C60	Kd = 27 nM	NF3	C6 H8 O4	CCOC(=O)/C....
6	4ZY3	-	K67	C29 H30 N2 O7 S2	CCOc1ccc(c....
7	7C5E	Kd = 8.4 nM	FUM	C4 H4 O4	C(=C/C(=O)....
8	5FZJ	-	75K	C8 H7 N O3	Cc1nc2c(o1....
9	6Z6A	Kd = 3.7 uM	Q9E	C23 H30 N4 O6 S	CC(=O)N1CC....
10	3ZGC	-	GLY ASP GLU GLU THR GLY GLU	n/a	n/a
11	5FNR	Kd = 59 uM	XMS	C16 H14 Cl N3 O2	Cn1c2ccc(c....
12	6QMC	-	J6H	C14 H12 Cl N O3	c1cc(ccc1[....
13	5FNS	Kd = 4 uM	XYY	C19 H21 Cl N4 O4 S	Cn1c2ccc(c....
14	1X2R	Ka = 5510000 M^-1	LEU ASP GLU GLU THR GLY GLU PHE LEU	n/a	n/a
15	6QMD	ic50 = 170 uM	J6N	C16 H14 Cl N3 O2	Cn1c2ccc(c....
16	6LRZ	Kd = 10 nM	EOU	C6 H8 O4	COC(=O)/C=....
17	6UF0	ic50 = 230 nM	Q5Y	C26 H24 N2 O8 S2	COc1ccc(cc....
18	6V6Z	ic50 = 63 nM	Q5Y	C26 H24 N2 O8 S2	COc1ccc(cc....
19	5FNQ	-	S0W	C9 H9 Cl O2	c1cc(ccc1C....
20	6TYP	Kd = 2.7 nM	PKG	C28 H28 N4 O3	CCn1c2ccc(....
21	6QME	ic50 = 44 uM	J6Q	C17 H16 Cl N3 O2	Cc1cc(ccc1....
22	4L7D	ic50 = 0.75 uM	1VX	C27 H30 N2 O4	Cc1cccc2c1....
23	6TYM	Kd = 13.5 nM	08A	C29 H30 N4 O3	CCn1c2ccc(....
24	5FZN	-	FB2	C6 H7 N O2 S	c1ccc(cc1)....
25	5X54	Kd = 10 uM	ACE GLU TRP TRP TRP	n/a	n/a
26	6QMJ	ic50 = 0.069 uM	J6K	C26 H28 N4 O5 S	Cc1ccc(cc1....
27	4L7B	ic50 = 2.3 uM	1VV	C26 H26 N2 O5	c1ccc2c(c1....
28	4IQK	ic50 = 2.7 uM	IQK	C24 H22 N2 O6 S2	COc1ccc(cc....
29	4XMB	Kd = 44 nM	41P	C28 H28 N4 O8 S2	COc1ccc(cc....
30	6QMK	ic50 = 0.047 uM	J8H	C27 H28 N4 O6 S	Cc1ccc(cc1....
31	6FMQ	-	ACE DYW GLU THR GLY GLU LEU	n/a	n/a

50% Homology Family (31)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 1144 families.
1	6T7Z	ic50 = 55 nM	ACY MV5 ASA 4FB GLU THR GLY GLU	n/a	n/a
2	5FNT	Kd = 0.67 uM	0PL	C24 H23 Cl N4 O4 S	Cn1c2ccc(c....
3	4L7C	ic50 = 7.4 uM	1VW	C26 H26 N6 O3	c1ccc2c(c1....
4	5FNU	Kd = 0.0013 uM	L6I	C28 H30 N4 O6 S	Cc1ccc(cc1....
5	7C60	Kd = 27 nM	NF3	C6 H8 O4	CCOC(=O)/C....
6	4ZY3	-	K67	C29 H30 N2 O7 S2	CCOc1ccc(c....
7	7C5E	Kd = 8.4 nM	FUM	C4 H4 O4	C(=C/C(=O)....
8	5FZJ	-	75K	C8 H7 N O3	Cc1nc2c(o1....
9	6Z6A	Kd = 3.7 uM	Q9E	C23 H30 N4 O6 S	CC(=O)N1CC....
10	3ZGC	-	GLY ASP GLU GLU THR GLY GLU	n/a	n/a
11	5FNR	Kd = 59 uM	XMS	C16 H14 Cl N3 O2	Cn1c2ccc(c....
12	6QMC	-	J6H	C14 H12 Cl N O3	c1cc(ccc1[....
13	5FNS	Kd = 4 uM	XYY	C19 H21 Cl N4 O4 S	Cn1c2ccc(c....
14	1X2R	Ka = 5510000 M^-1	LEU ASP GLU GLU THR GLY GLU PHE LEU	n/a	n/a
15	6QMD	ic50 = 170 uM	J6N	C16 H14 Cl N3 O2	Cn1c2ccc(c....
16	6LRZ	Kd = 10 nM	EOU	C6 H8 O4	COC(=O)/C=....
17	6UF0	ic50 = 230 nM	Q5Y	C26 H24 N2 O8 S2	COc1ccc(cc....
18	6V6Z	ic50 = 63 nM	Q5Y	C26 H24 N2 O8 S2	COc1ccc(cc....
19	5FNQ	-	S0W	C9 H9 Cl O2	c1cc(ccc1C....
20	6TYP	Kd = 2.7 nM	PKG	C28 H28 N4 O3	CCn1c2ccc(....
21	6QME	ic50 = 44 uM	J6Q	C17 H16 Cl N3 O2	Cc1cc(ccc1....
22	4L7D	ic50 = 0.75 uM	1VX	C27 H30 N2 O4	Cc1cccc2c1....
23	6TYM	Kd = 13.5 nM	08A	C29 H30 N4 O3	CCn1c2ccc(....
24	5FZN	-	FB2	C6 H7 N O2 S	c1ccc(cc1)....
25	5X54	Kd = 10 uM	ACE GLU TRP TRP TRP	n/a	n/a
26	6QMJ	ic50 = 0.069 uM	J6K	C26 H28 N4 O5 S	Cc1ccc(cc1....
27	4L7B	ic50 = 2.3 uM	1VV	C26 H26 N2 O5	c1ccc2c(c1....
28	4IQK	ic50 = 2.7 uM	IQK	C24 H22 N2 O6 S2	COc1ccc(cc....
29	4XMB	Kd = 44 nM	41P	C28 H28 N4 O8 S2	COc1ccc(cc....
30	6QMK	ic50 = 0.047 uM	J8H	C27 H28 N4 O6 S	Cc1ccc(cc1....
31	6FMQ	-	ACE DYW GLU THR GLY GLU LEU	n/a	n/a

Polypharmacology

Similar Ligands (2D)

Ligand no: 1; Ligand: 75K; Similar ligands found: 1

No:	Ligand	ECFP6 Tc	MDL keys Tc
1	75K	1	1

Similar Ligands (3D)

Ligand no: 1; Ligand: 75K; Similar ligands found: 1193

No:	Ligand	Similarity coefficient
1	URC	1.0000
2	B55	1.0000
3	8TX	1.0000
4	XAZ	1.0000
5	BTY	0.9980
6	5JL	0.9942
7	QBK	0.9937
8	5JQ	0.9936
9	8IG	0.9906
10	9DG	0.9792
11	AZ8	0.9790
12	GUN	0.9775
13	M6N	0.9774
14	BGC	0.9774
15	PE0	0.9768
16	J9W	0.9767
17	AZA	0.9764
18	M5K	0.9758
19	MEW	0.9747
20	AJ2	0.9744
21	AQO	0.9732
22	Q24	0.9730
23	ES0	0.9727
24	XAN	0.9727
25	CWM	0.9725
26	YH7	0.9719
27	IGA	0.9716
28	MUA	0.9712
29	4HC	0.9707
30	AZG	0.9695
31	1XM	0.9689
32	ET2	0.9687
33	BOA	0.9687
34	A2F	0.9683
35	M1Q	0.9678
36	141	0.9676
37	DX4	0.9663
38	Q88	0.9655
39	VGD	0.9644
40	QX4	0.9644
41	6AP	0.9643
42	36R	0.9642
43	0FO	0.9637
44	B62	0.9637
45	1P8	0.9633
46	5VM	0.9632
47	ES2	0.9630
48	KT7	0.9621
49	CLW	0.9621
50	BCP	0.9618
51	GLC	0.9618
52	XHP	0.9617
53	CFP	0.9613
54	2D0	0.9605
55	290	0.9604
56	0CU	0.9602
57	DQU	0.9598
58	2AK	0.9590
59	4MU	0.9587
60	OTW	0.9585
61	4ME	0.9567
62	HH5	0.9558
63	XQ0	0.9552
64	44W	0.9543
65	HMH	0.9543
66	FBB	0.9540
67	CWJ	0.9539
68	H42	0.9530
69	A7W	0.9527
70	IV2	0.9526
71	MVN	0.9522
72	FYU	0.9521
73	K2T	0.9518
74	6VD	0.9517
75	VK3	0.9515
76	RXA	0.9515
77	RM1	0.9513
78	VNL	0.9505
79	5SG	0.9503
80	AZ9	0.9498
81	DRL	0.9494
82	HQY	0.9492
83	44V	0.9490
84	NQ	0.9488
85	EA1	0.9488
86	5IQ	0.9482
87	1NP	0.9481
88	HQD	0.9481
89	FA0	0.9476
90	EV0	0.9476
91	5Q0	0.9476
92	NOJ	0.9476
93	DOB	0.9475
94	BHA	0.9475
95	0N7	0.9475
96	4M0	0.9472
97	6RQ	0.9472
98	COU	0.9472
99	BZX	0.9469
100	2EC	0.9469
101	N5J	0.9468
102	G3F	0.9468
103	O72	0.9467
104	DIN	0.9464
105	4YS	0.9464
106	ES1	0.9464
107	5NU	0.9463
108	S76	0.9463
109	5OB	0.9462
110	3F0	0.9461
111	9MG	0.9458
112	PQ0	0.9456
113	24W	0.9456
114	0P6	0.9455
115	1SQ	0.9455
116	2AQ	0.9454
117	86J	0.9453
118	MS9	0.9453
119	4FS	0.9450
120	5CU	0.9449
121	MRW	0.9446
122	2AL	0.9446
123	OCH	0.9445
124	1LM	0.9445
125	GCS	0.9442
126	J9Q	0.9441
127	JB5	0.9440
128	6ME	0.9440
129	HJP	0.9439
130	AS3	0.9438
131	2HQ	0.9438
132	KIB	0.9437
133	03V	0.9436
134	ES9	0.9436
135	ODO	0.9436
136	4HM	0.9435
137	JPZ	0.9433
138	FDB	0.9433
139	BZ3	0.9432
140	KUF	0.9432
141	2K4	0.9431
142	F60	0.9431
143	UEG	0.9431
144	JBH	0.9429
145	PH2	0.9427
146	11S	0.9425
147	94W	0.9424
148	14O	0.9424
149	3ID	0.9423
150	FK1	0.9423
151	JND	0.9422
152	1LQ	0.9421
153	92K	0.9420
154	5H1	0.9420
155	ORO	0.9420
156	CWS	0.9419
157	7VS	0.9419
158	M0Q	0.9418
159	INE	0.9418
160	ZZT	0.9417
161	7NI	0.9417
162	ES5	0.9415
163	MO8	0.9413
164	6AI	0.9410
165	SYV	0.9409
166	5MI	0.9408
167	H4N	0.9406
168	7HQ	0.9405
169	H33	0.9405
170	3DM	0.9403
171	FOT	0.9402
172	APZ	0.9401
173	8WO	0.9401
174	3M0	0.9400
175	KKN	0.9397
176	BEA	0.9397
177	4TU	0.9395
178	UNC	0.9395
179	8CM	0.9394
180	5MB	0.9394
181	KJU	0.9393
182	DMD	0.9391
183	209	0.9387
184	97T	0.9387
185	AX7	0.9383
186	TWO	0.9383
187	7W4	0.9380
188	270	0.9379
189	3HA	0.9379
190	ISN	0.9378
191	AX3	0.9377
192	F0J	0.9376
193	NID	0.9376
194	5XC	0.9375
195	I3A	0.9375
196	67N	0.9375
197	B53	0.9375
198	DBH	0.9371
199	LZM	0.9367
200	8WT	0.9366
201	HMU	0.9366
202	10L	0.9364
203	G3E	0.9364
204	5RO	0.9363
205	42A	0.9363
206	8S0	0.9362
207	8NX	0.9361
208	M1H	0.9361
209	4XH	0.9360
210	B60	0.9360
211	2A9	0.9360
212	P92	0.9358
213	OXC	0.9357
214	QPR	0.9356
215	R8V	0.9356
216	JAE	0.9354
217	5WV	0.9352
218	FE DB1	0.9352
219	SHA	0.9352
220	B57	0.9352
221	V55	0.9348
222	HPA	0.9348
223	TTL	0.9348
224	QWN	0.9346
225	2MI	0.9346
226	7B4	0.9343
227	MAQ	0.9342
228	5WY	0.9342
229	Q6T	0.9340
230	1XN	0.9338
231	8H8	0.9337
232	5RN	0.9337
233	0W8	0.9337
234	HH8	0.9334
235	2A7	0.9333
236	4CS	0.9332
237	ES7	0.9330
238	IJZ	0.9329
239	7ME	0.9329
240	ADE	0.9328
241	9R5	0.9325
242	BDP	0.9324
243	82I	0.9323
244	N8Y	0.9322
245	CLZ	0.9318
246	42C	0.9318
247	7WA	0.9318
248	D07	0.9317
249	8NY	0.9315
250	BP1	0.9315
251	HLZ	0.9314
252	F9Y	0.9314
253	2FQ	0.9314
254	M1A	0.9314
255	NDM	0.9313
256	7W1	0.9312
257	2ZQ	0.9312
258	ICO	0.9308
259	AKH	0.9307
260	2F6	0.9307
261	AHR	0.9306
262	8GC	0.9306
263	9HX	0.9305
264	6MP	0.9305
265	Z5P	0.9304
266	TEP	0.9303
267	KYA	0.9303
268	3PF	0.9302
269	SWA	0.9302
270	20J	0.9300
271	7HP	0.9296
272	KIA	0.9294
273	5GU	0.9294
274	12Q	0.9293
275	2H5	0.9293
276	23A	0.9291
277	MR1	0.9291
278	9DA	0.9290
279	MQN	0.9289
280	PXL	0.9289
281	OVM	0.9288
282	ADZ	0.9287
283	NMJ	0.9287
284	KJH	0.9286
285	4JQ	0.9285
286	ABV	0.9285
287	3NT	0.9284
288	XYP	0.9283
289	261	0.9282
290	BTE	0.9281
291	12B	0.9280
292	QXW	0.9279
293	SVN	0.9279
294	24B	0.9277
295	C2U	0.9275
296	4AA	0.9275
297	UAN	0.9275
298	3MG	0.9275
299	3HB	0.9274
300	4XR	0.9274
301	PRF	0.9273
302	7MU	0.9272
303	3MB	0.9272
304	3Z8	0.9272
305	5HN	0.9271
306	D48	0.9270
307	DOR	0.9270
308	J6W	0.9269
309	XQG	0.9268
310	FDR	0.9268
311	1P7	0.9267
312	5QY	0.9267
313	M1E	0.9266
314	J5I	0.9266
315	7ZE	0.9265
316	PXM	0.9264
317	5QX	0.9263
318	3AB	0.9263
319	GAB	0.9260
320	4JT	0.9260
321	PDC	0.9260
322	SE2	0.9259
323	GAL	0.9257
324	OVV	0.9256
325	K22	0.9256
326	9KT	0.9256
327	5RG	0.9255
328	SOE	0.9253
329	CTL	0.9252
330	WCE	0.9251
331	34D	0.9249
332	DHK	0.9248
333	Q71	0.9246
334	1M2	0.9245
335	JTH	0.9245
336	ES4	0.9243
337	N2I	0.9243
338	BE2	0.9240
339	AW5	0.9238
340	II6	0.9238
341	SKA	0.9237
342	6M9	0.9237
343	0TU	0.9236
344	K3Q	0.9234
345	D1X	0.9233
346	LXC	0.9233
347	5B1	0.9231
348	3IT	0.9231
349	PM6	0.9228
350	PYQ	0.9228
351	HQT	0.9228
352	52C	0.9228
353	2FG	0.9228
354	HIS	0.9228
355	4NC	0.9225
356	XIY	0.9225
357	GDE	0.9224
358	0RW	0.9222
359	M2K	0.9221
360	HHA	0.9220
361	PRZ	0.9220
362	4YO	0.9219
363	SXS	0.9219
364	DIU	0.9219
365	KJY	0.9218
366	SAL	0.9218
367	HQJ	0.9218
368	8ZE	0.9216
369	3BZ	0.9214
370	MT0	0.9212
371	FP1	0.9211
372	GIO	0.9211
373	TT4	0.9210
374	F05	0.9210
375	VOH	0.9210
376	9EW	0.9209
377	GXY	0.9207
378	CTS	0.9207
379	OW4	0.9206
380	1DW	0.9206
381	K32	0.9203
382	6CS	0.9203
383	EUG	0.9202
384	AJV	0.9200
385	GJS	0.9200
386	JLZ	0.9199
387	BRT	0.9198
388	680	0.9198
389	KDV	0.9197
390	DHB	0.9196
391	JBQ	0.9196
392	6NT	0.9196
393	F12	0.9195
394	XX2	0.9193
395	F81	0.9193
396	53C	0.9192
397	5WX	0.9192
398	GM7	0.9190
399	E7S	0.9190
400	A29	0.9185
401	2LY	0.9182
402	495	0.9182
403	TH7	0.9182
404	PEY	0.9181
405	6M4	0.9181
406	5M0	0.9180
407	3WA	0.9179
408	B5D	0.9178
409	4M4	0.9178
410	7WR	0.9178
411	92P	0.9177
412	A13	0.9177
413	9FL	0.9176
414	BPU	0.9175
415	X0W	0.9174
416	MYJ	0.9174
417	INO	0.9174
418	4SV	0.9172
419	2HU	0.9172
420	DBJ	0.9170
421	NSP	0.9170
422	JBE	0.9168
423	LGC	0.9166
424	R9Y	0.9165
425	GTQ	0.9164
426	ZZ3	0.9162
427	ASO	0.9160
428	2ZM	0.9158
429	EQT	0.9158
430	YQA	0.9158
431	KOJ	0.9157
432	CFF	0.9157
433	SKM	0.9156
434	0HO	0.9155
435	3HM	0.9153
436	R8S	0.9153
437	QUZ	0.9152
438	FHB	0.9151
439	E7Z	0.9151
440	P9P	0.9151
441	PQK	0.9151
442	G5V	0.9150
443	3NY	0.9150
444	HZQ	0.9149
445	HHR	0.9148
446	GZ8	0.9148
447	0F9	0.9148
448	0JD	0.9146
449	4A3	0.9145
450	5UC	0.9144
451	5NI	0.9143
452	E5X	0.9141
453	54G	0.9140
454	XM0	0.9140
455	TSS	0.9140
456	LI6	0.9139
457	NPY	0.9139
458	K17	0.9139
459	NNO	0.9137
460	LDR	0.9137
461	G6D	0.9134
462	3OC	0.9132
463	93K	0.9131
464	1F1	0.9130
465	C2Y	0.9127
466	6NI	0.9125
467	GIV	0.9123
468	149	0.9123
469	12T	0.9122
470	JG8	0.9122
471	8W9	0.9120
472	ADK	0.9120
473	QAT	0.9119
474	2HO	0.9116
475	QAS	0.9115
476	GCU	0.9114
477	M0W	0.9113
478	TH0	0.9112
479	2KA	0.9111
480	0W1	0.9111
481	NDH	0.9110
482	069	0.9110
483	DFB	0.9110
484	0HN	0.9109
485	GLA	0.9107
486	ICP	0.9106
487	3FH	0.9106
488	GRE	0.9105
489	CH9	0.9105
490	4Z4	0.9104
491	3A9	0.9104
492	NAG	0.9103
493	4XV	0.9102
494	ES6	0.9102
495	3MA	0.9102
496	15N	0.9102
497	UFO	0.9102
498	7B3	0.9101
499	URF	0.9101
500	F31	0.9101
501	TGX	0.9100
502	IPB	0.9100
503	TDR	0.9098
504	OMD	0.9098
505	PHB	0.9097
506	ABI	0.9096
507	39U	0.9096
508	1MC	0.9095
509	G2F	0.9094
510	1GN	0.9094
511	293	0.9093
512	9TZ	0.9092
513	GZL	0.9092
514	32X	0.9091
515	IFL	0.9091
516	TTY	0.9088
517	3U4	0.9087
518	BK9	0.9087
519	TOF	0.9086
520	6KT	0.9086
521	PX7	0.9086
522	QSH	0.9086
523	DNC	0.9084
524	DNF	0.9083
525	9AP	0.9082
526	X05	0.9079
527	3Z7	0.9076
528	NPO	0.9076
529	NGO	0.9076
530	DNA	0.9075
531	PZI	0.9075
532	QSB	0.9074
533	SHG	0.9074
534	PD2	0.9073
535	HX3	0.9071
536	LSA	0.9071
537	HNQ	0.9070
538	JKE	0.9069
539	CHB	0.9068
540	6F0	0.9067
541	PFB	0.9067
542	WBU	0.9066
543	L5V	0.9066
544	37T	0.9066
545	43M	0.9064
546	DHQ	0.9061
547	NIZ	0.9060
548	BMA	0.9059
549	OVP	0.9058
550	GTR	0.9058
551	1PT	0.9058
552	2FY	0.9057
553	2ZV	0.9057
554	4FA	0.9057
555	JAW	0.9056
556	MCT	0.9056
557	HLD	0.9056
558	FGZ	0.9055
559	7WV	0.9054
560	9TW	0.9053
561	PYD	0.9053
562	BCU	0.9052
563	DHR	0.9052
564	PAB	0.9052
565	FBG	0.9052
566	7VJ	0.9050
567	2AC	0.9048
568	8XQ	0.9047
569	XYD	0.9044
570	2LP	0.9044
571	173	0.9044
572	TBS	0.9044
573	1WD	0.9043
574	DGJ	0.9043
575	TIU	0.9043
576	9CA	0.9042
577	SX1	0.9041
578	4HO	0.9041
579	2MP	0.9040
580	EMZ	0.9040
581	34A	0.9039
582	JIF	0.9039
583	XBZ	0.9038
584	4ZE	0.9038
585	5MK	0.9037
586	X8D	0.9036
587	K97	0.9036
588	LT2	0.9035
589	PNZ	0.9035
590	QWW	0.9034
591	MBG	0.9032
592	344	0.9031
593	GYE	0.9031
594	FLV	0.9030
595	4XS	0.9029
596	JZ2	0.9028
597	25W	0.9028
598	MWM	0.9027
599	4CL	0.9027
600	JU2	0.9027
601	275	0.9027
602	BZI	0.9027
603	0GZ	0.9025
604	NOY	0.9025
605	4ZC	0.9024
606	NTM	0.9024
607	4JJ	0.9023
608	M4E	0.9020
609	PHT	0.9019
610	A1U	0.9018
611	QOS	0.9018
612	QX2	0.9018
613	OA3	0.9018
614	FRU	0.9018
615	ONR	0.9016
616	6M1	0.9016
617	EVA	0.9016
618	226	0.9014
619	EJZ	0.9013
620	DEN	0.9013
621	RPQ	0.9013
622	BHO	0.9011
623	2BG	0.9010
624	51R	0.9010
625	15L	0.9008
626	Q7A	0.9008
627	E1T	0.9005
628	1IT	0.9005
629	HBA	0.9005
630	SRO	0.9005
631	NDG	0.9005
632	IND	0.9004
633	30G	0.9004
634	2CK	0.9003
635	0FN	0.9003
636	1A7	0.9001
637	VXX	0.9000
638	B2J	0.8999
639	27Y	0.8998
640	IHB	0.8998
641	3XX	0.8998
642	BR9	0.8997
643	5MH	0.8997
644	LKA	0.8997
645	ZYR	0.8995
646	HDH	0.8994
647	TM7	0.8994
648	IUR	0.8993
649	MWP	0.8993
650	H5B	0.8992
651	6BL	0.8992
652	4BY	0.8992
653	4JO	0.8991
654	I6G	0.8991
655	428	0.8990
656	329	0.8989
657	JFJ	0.8989
658	JZ3	0.8989
659	LDP	0.8988
660	3QV	0.8987
661	BZF	0.8984
662	ZVO	0.8983
663	ANN	0.8983
664	IFP	0.8983
665	0CT	0.8983
666	X09	0.8982
667	ESI	0.8982
668	JDN	0.8981
669	7MX	0.8979
670	PFL	0.8979
671	MPI	0.8978
672	BZJ	0.8976
673	LZ1	0.8976
674	2YU	0.8976
675	3RK	0.8976
676	DPZ	0.8975
677	2K8	0.8975
678	HLR	0.8974
679	NTZ	0.8974
680	E35	0.8973
681	G12	0.8973
682	39A	0.8973
683	HKD	0.8973
684	JBK	0.8972
685	MWJ	0.8971
686	4BL	0.8971
687	DIE	0.8971
688	8G0	0.8970
689	BZ2	0.8970
690	FUD	0.8970
691	GCB	0.8969
692	HBD	0.8969
693	XXR	0.8969
694	GLY PRO	0.8967
695	HT4	0.8966
696	AA	0.8966
697	0R0	0.8966
698	GIF	0.8966
699	23J	0.8965
700	1Y6	0.8965
701	5JC	0.8964
702	CKA	0.8963
703	MZG	0.8963
704	717	0.8962
705	KTW	0.8962
706	XYS	0.8962
707	PKU	0.8961
708	GAF	0.8961
709	ZZ8	0.8960
710	C9E	0.8960
711	GVH	0.8960
712	YSO	0.8960
713	W81	0.8958
714	SOR	0.8958
715	ISZ	0.8957
716	0R1	0.8956
717	15E	0.8955
718	JUG	0.8951
719	BEZ	0.8951
720	1AL	0.8946
721	RIP	0.8946
722	HA7	0.8945
723	ALL	0.8945
724	8HC	0.8944
725	BAM	0.8944
726	RSF	0.8944
727	AEF	0.8943
728	DRG	0.8943
729	F5B	0.8943
730	6GU	0.8939
731	RD4	0.8939
732	K37	0.8938
733	MAN	0.8938
734	6PC	0.8938
735	JR2	0.8937
736	BEN	0.8937
737	N3W	0.8936
738	M1Z	0.8935
739	1WG	0.8935
740	8OZ	0.8934
741	FUL	0.8934
742	5VL	0.8933
743	TLD	0.8932
744	1P3	0.8932
745	1KP	0.8930
746	WOO	0.8930
747	AIN	0.8930
748	3AL	0.8929
749	4VP	0.8929
750	K5W	0.8928
751	X6X	0.8928
752	0FK	0.8926
753	MNM	0.8926
754	NVU	0.8926
755	T6C	0.8925
756	JXN	0.8925
757	6TZ	0.8925
758	GJP	0.8922
759	7MH	0.8922
760	JB8	0.8922
761	Z82	0.8922
762	GCO	0.8920
763	AGK	0.8919
764	4P5	0.8919
765	GV9	0.8918
766	ZZZ	0.8916
767	0MK	0.8915
768	9ZE	0.8914
769	ICB	0.8914
770	IF7	0.8913
771	UNJ	0.8912
772	4BZ	0.8912
773	CFI	0.8911
774	4VS	0.8911
775	PA1	0.8911
776	GOJ	0.8910
777	47J	0.8910
778	DX3	0.8908
779	DBX	0.8905
780	FBU	0.8903
781	SLS	0.8903
782	1HN	0.8902
783	3R6	0.8902
784	AZF	0.8902
785	G1O	0.8901
786	ADA	0.8901
787	IUP	0.8900
788	3ZB	0.8900
789	HHS	0.8900
790	YRL	0.8898
791	NGT	0.8898
792	4MA	0.8896
793	RB5	0.8896
794	39O	0.8894
795	4RU	0.8894
796	PHH	0.8893
797	G4D	0.8893
798	IFM	0.8893
799	FA3	0.8893
800	LCN	0.8891
801	PBZ	0.8890
802	ANF	0.8890
803	OXQ	0.8890
804	GOX	0.8888
805	FUC	0.8888
806	UFV	0.8886
807	THA	0.8886
808	TXW	0.8885
809	AC6	0.8885
810	PJW	0.8885
811	NCA	0.8885
812	GT0	0.8884
813	GBD	0.8883
814	IDM	0.8883
815	4KL	0.8883
816	ZWZ	0.8883
817	42J	0.8882
818	826	0.8882
819	K8X	0.8882
820	TYL	0.8881
821	EKZ	0.8880
822	LYL	0.8880
823	EYK	0.8880
824	2CQ	0.8878
825	EXO	0.8878
826	12M	0.8877
827	YCP	0.8877
828	JP2	0.8875
829	NK	0.8875
830	JA8	0.8875
831	GXL	0.8874
832	FBT	0.8874
833	BSX	0.8871
834	Y8I	0.8871
835	EN1	0.8871
836	JZ9	0.8870
837	ROI	0.8870
838	J9T	0.8870
839	3SK	0.8870
840	PHE	0.8869
841	KLW	0.8867
842	1X7	0.8866
843	FDK	0.8864
844	6UA	0.8863
845	5NE	0.8862
846	VNJ	0.8862
847	X0V	0.8861
848	AY4	0.8860
849	174	0.8860
850	150	0.8858
851	ZB1	0.8856
852	TFU	0.8856
853	FA1	0.8854
854	Q77	0.8851
855	HTP	0.8851
856	PHU	0.8850
857	JFD	0.8849
858	IAC	0.8849
859	GAG	0.8848
860	OXZ	0.8848
861	F2W	0.8847
862	0XT	0.8847
863	P3K	0.8846
864	KFH	0.8846
865	GVG	0.8846
866	NBZ	0.8845
867	KYD	0.8845
868	FBW	0.8845
869	45L	0.8845
870	OW7	0.8844
871	JKZ	0.8844
872	HA5	0.8844
873	FH2	0.8842
874	6FZ	0.8842
875	AEZ	0.8842
876	HBO	0.8840
877	9FE	0.8840
878	EXD	0.8840
879	2MN	0.8840
880	27B	0.8840
881	YIO	0.8840
882	INS	0.8840
883	NIO	0.8838
884	4WL	0.8837
885	OTR	0.8834
886	A7H	0.8833
887	67X	0.8833
888	XBT	0.8831
889	DMJ	0.8830
890	SW7	0.8830
891	ARB	0.8830
892	HY3	0.8830
893	XXP	0.8829
894	M4T	0.8828
895	AJY	0.8828
896	FBM	0.8828
897	IDH	0.8827
898	FB1	0.8827
899	GHM	0.8825
900	TBP	0.8825
901	GIM	0.8825
902	KBG	0.8824
903	P72	0.8823
904	DFU	0.8822
905	LT8	0.8822
906	RAM	0.8822
907	JXW	0.8822
908	7I2	0.8821
909	OTD	0.8821
910	P84	0.8820
911	HXX	0.8820
912	URQ	0.8820
913	MVL	0.8819
914	BDF	0.8818
915	PEA	0.8818
916	45C	0.8815
917	6LW	0.8814
918	CN0	0.8813
919	VGL	0.8813
920	K82	0.8813
921	V6F	0.8813
922	DEE	0.8812
923	M5N	0.8811
924	091	0.8807
925	CFA	0.8807
926	28N	0.8807
927	60P	0.8804
928	PYG	0.8803
929	UNU	0.8802
930	ASC	0.8800
931	H8N	0.8799
932	IPZ	0.8798
933	3R4	0.8797
934	R20	0.8797
935	ZXD	0.8797
936	R9S	0.8795
937	MJ2	0.8794
938	XCZ	0.8793
939	F9P	0.8793
940	3BU	0.8791
941	BR8	0.8790
942	GTL	0.8789
943	NSG	0.8789
944	PZA	0.8789
945	RMN	0.8789
946	BPN	0.8789
947	3DO	0.8788
948	K6X	0.8787
949	8NB	0.8787
950	4VY	0.8787
951	286	0.8786
952	GF4	0.8786
953	PIM	0.8786
954	14J	0.8785
955	KTJ	0.8784
956	MSR	0.8784
957	AX2	0.8784
958	F69	0.8781
959	OAA	0.8781
960	3AY	0.8781
961	FPY	0.8780
962	J01	0.8779
963	1U6	0.8778
964	P4B	0.8775
965	SF9	0.8774
966	CIT	0.8773
967	4NM	0.8772
968	R8A	0.8772
969	F4Z	0.8771
970	FCA	0.8770
971	C2A	0.8770
972	5WU	0.8769
973	GTZ	0.8769
974	SR1	0.8769
975	EOL	0.8768
976	4ZA	0.8768
977	NTN	0.8767
978	LNR	0.8766
979	5ZE	0.8764
980	MFB	0.8764
981	8XL	0.8763
982	RHU	0.8762
983	35C	0.8761
984	AFR	0.8760
985	L99	0.8760
986	GMN	0.8760
987	60Q	0.8758
988	FAN	0.8758
989	GCV	0.8757
990	GNM	0.8755
991	KW8	0.8755
992	AC0	0.8754
993	46P	0.8753
994	4V2	0.8751
995	RSO	0.8751
996	7FF	0.8750
997	RIB	0.8750
998	NGA	0.8749
999	2GS	0.8748
1000	P9E	0.8748
1001	FCB	0.8748
1002	2DR	0.8748
1003	HFB	0.8747
1004	7D2	0.8747
1005	6MH	0.8747
1006	1WC	0.8747
1007	A65	0.8747
1008	MAJ	0.8746
1009	5AN	0.8745
1010	GDL	0.8745
1011	4I8	0.8743
1012	RNS	0.8743
1013	RM4	0.8743
1014	BPY	0.8742
1015	QIC	0.8742
1016	NLA	0.8742
1017	49O	0.8741
1018	H7Y	0.8740
1019	TC7	0.8740
1020	GOG	0.8740
1021	GSY	0.8740
1022	MBD	0.8740
1023	NCT	0.8738
1024	13X	0.8738
1025	PIY	0.8738
1026	JYB	0.8737
1027	6XI	0.8736
1028	2MY	0.8736
1029	GNL	0.8735
1030	XUL	0.8735
1031	TZF	0.8733
1032	N7I	0.8733
1033	DA4	0.8730
1034	6R8	0.8730
1035	61M	0.8727
1036	AN3	0.8725
1037	RBL	0.8725
1038	K34	0.8724
1039	ESX	0.8724
1040	DUB	0.8723
1041	ESP	0.8722
1042	8GK	0.8722
1043	FQI	0.8721
1044	DQA	0.8721
1045	GOO	0.8721
1046	F4E	0.8720
1047	463	0.8720
1048	6OT	0.8720
1049	ERH	0.8720
1050	259	0.8719
1051	H76	0.8719
1052	TPA	0.8719
1053	4FH	0.8718
1054	SN4	0.8718
1055	O2A	0.8717
1056	2HC	0.8715
1057	XRG	0.8715
1058	4JM	0.8715
1059	V1T	0.8714
1060	IWT	0.8714
1061	H6B	0.8714
1062	FBV	0.8713
1063	SNU	0.8712
1064	FLC	0.8712
1065	DQN	0.8710
1066	HHT	0.8709
1067	M6Z	0.8709
1068	FCR	0.8708
1069	MT5	0.8708
1070	K25	0.8706
1071	68A	0.8705
1072	3FA	0.8703
1073	PBC	0.8700
1074	3CE	0.8700
1075	95Z	0.8700
1076	IBF	0.8699
1077	6QF	0.8697
1078	1U1	0.8697
1079	06B	0.8696
1080	AH8	0.8695
1081	DE5	0.8695
1082	NGW	0.8695
1083	LMR	0.8695
1084	4SX	0.8695
1085	2ZX	0.8695
1086	PBA	0.8692
1087	23W	0.8692
1088	7CZ	0.8691
1089	549	0.8691
1090	SNO	0.8691
1091	PAC	0.8691
1092	5NS	0.8691
1093	L3Q	0.8690
1094	1XA	0.8689
1095	54X	0.8685
1096	FUF	0.8684
1097	5LA	0.8682
1098	2C9	0.8682
1099	AEH	0.8681
1100	SLC	0.8680
1101	2CM	0.8680
1102	F1A	0.8677
1103	BCF	0.8676
1104	BNT	0.8676
1105	BBF	0.8673
1106	3MC	0.8672
1107	GLT	0.8671
1108	4JP	0.8671
1109	IP0	0.8669
1110	0TR	0.8667
1111	XQI	0.8666
1112	CPZ	0.8666
1113	SG2	0.8663
1114	FBA	0.8663
1115	ABE	0.8661
1116	SYA	0.8661
1117	XYL	0.8660
1118	0LH	0.8660
1119	DHS	0.8660
1120	1DV	0.8659
1121	AMH	0.8657
1122	MPV	0.8654
1123	4A5	0.8650
1124	WDL	0.8650
1125	SRT	0.8650
1126	TSU	0.8645
1127	FLM	0.8641
1128	RNO	0.8636
1129	94N	0.8635
1130	XQK	0.8634
1131	9PY	0.8634
1132	IQ5	0.8631
1133	LPK	0.8631
1134	X0U	0.8630
1135	DS0	0.8630
1136	PZM	0.8628
1137	EGR	0.8627
1138	S0E	0.8627
1139	BIK	0.8623
1140	FFP	0.8623
1141	5VJ	0.8623
1142	OK7	0.8622
1143	SWD	0.8621
1144	WOT	0.8620
1145	FA6	0.8617
1146	KP6	0.8616
1147	6Q3	0.8613
1148	Q02	0.8613
1149	J9N	0.8610
1150	M3H	0.8610
1151	5FN	0.8609
1152	F3B	0.8609
1153	E3D	0.8609
1154	3J8	0.8608
1155	FPK	0.8605
1156	4NB	0.8602
1157	ENL	0.8601
1158	DK1	0.8600
1159	1Z6	0.8600
1160	5OF	0.8600
1161	HC4	0.8599
1162	BSP	0.8598
1163	HBX	0.8598
1164	KDF	0.8592
1165	KTA	0.8592
1166	LRH	0.8590
1167	9RW	0.8587
1168	LEL	0.8585
1169	QQQ	0.8583
1170	2JK	0.8581
1171	S60	0.8580
1172	4JL	0.8579
1173	5TY	0.8573
1174	TAR	0.8569
1175	TVP	0.8567
1176	CK2	0.8567
1177	BGU	0.8566
1178	LQ2	0.8565
1179	7N0	0.8565
1180	2O6	0.8565
1181	9LI	0.8565
1182	PYF	0.8562
1183	282	0.8561
1184	QSC	0.8560
1185	GCW	0.8555
1186	DYA	0.8551
1187	B56	0.8547
1188	5CL	0.8537
1189	GNV	0.8537
1190	A7N	0.8533
1191	IOS	0.8532
1192	N0Z	0.8525
1193	GTC	0.8508

Similar Binding Sites (Proteins are less than 50% similar to leader)

Pocket No.: 1; Query (leader) PDB : 5FNU; Ligand: L6I; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.

This union binding pocket(no: 1) in the query (biounit: 5fnu.bio1) has 42 residues
No:	Leader PDB	Ligand	Sequence Similarity

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