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Receptor
PDB id Resolution Class Description Source Keywords
5GM1 2.5 Å EC: 2.-.-.- CRYSTAL STRUCTURE OF METHYLTRANSFERASE TLED COMPLEXED WITH S STREPTOMYCES BLASTMYCETICUS TLED TELEOCIDIN METHYLTRANSFERASES TERPENE CYCLIZATION TRANSFERASE
Ref.: CRYSTAL STRUCTURE AND ENANTIOSELECTIVITY OF TERPENE CYCLIZATION IN SAM-DEPENDENT METHYLTRANSFERASE TLED BIOCHEM.J. V. 473 4385 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAH L:301;
C:301;
K:301;
H:301;
B:301;
P:301;
B:302;
G:301;
D:301;
M:301;
E:301;
Q:301;
I:301;
A:301;
R:301;
N:301;
O:301;
F:301;
J:301;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
384.411 C14 H20 N6 O5 S c1nc(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5GM1 2.5 Å EC: 2.-.-.- CRYSTAL STRUCTURE OF METHYLTRANSFERASE TLED COMPLEXED WITH S STREPTOMYCES BLASTMYCETICUS TLED TELEOCIDIN METHYLTRANSFERASES TERPENE CYCLIZATION TRANSFERASE
Ref.: CRYSTAL STRUCTURE AND ENANTIOSELECTIVITY OF TERPENE CYCLIZATION IN SAM-DEPENDENT METHYLTRANSFERASE TLED BIOCHEM.J. V. 473 4385 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 269 families.
1 5GM1 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 237 families.
1 5GM1 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 5GM1 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 480
This union binding pocket(no: 1) in the query (biounit: 5gm1.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 1WUW TSU None
2 2BZ1 TAU 1.02041
3 5D4V SAH 1.1194
4 2Q1W NAD 1.3468
5 2WK1 SAH 1.41844
6 4FC7 NAP 1.44404
7 4FC7 COA 1.44404
8 4ITU NAI 1.48699
9 4ITU 1HS 1.48699
10 2ZL4 ALA ALA ALA ALA 1.53061
11 4EUE NAI 1.6835
12 1YXM ADE 1.6835
13 4XQC NAD 1.6835
14 4RPL FAD 1.6835
15 4RPL 3UC 1.6835
16 5N0J FAD 1.6835
17 3U31 NAD 1.72414
18 3N8K D1X 1.74419
19 1U7T TDT 1.91571
20 1E3W NAD 1.91571
21 1E6W NAD 1.92308
22 4URF NAD 2.01613
23 4G7A AZM 2.01613
24 6FDF SAH 2.0202
25 1V6A TRE 2.0202
26 3WGT FAD 2.0202
27 3WGT QSC 2.0202
28 3ZNN 4WL 2.0202
29 3ZNN FAD 2.0202
30 2VZ6 FEF 2.0202
31 3A4V PYR 2.0202
32 2PZM UDP 2.0202
33 2PZM NAD 2.0202
34 5Z75 NAD 2.0202
35 5T8U LPA 2.0202
36 2J5V RGP 2.0202
37 2AOT SAH 2.05479
38 1JQD SAH 2.05479
39 1JQD HSM 2.05479
40 1SQL GUN 2.05479
41 3U40 ADN 2.06612
42 1LSS NAD 2.14286
43 4X7Y SAH 2.18978
44 1KYQ NAD 2.18978
45 4RF2 NAP 2.20588
46 1EJ0 SAM 2.22222
47 2DTX BMA 2.27273
48 2PWY SAH 2.32558
49 4N49 SAM 2.3569
50 2JHP SAH 2.3569
51 2OBM ADP 2.3569
52 3ML1 MGD 2.3569
53 3GD4 NAD 2.3569
54 3GD4 FAD 2.3569
55 4RL4 PPV 2.35849
56 3H8V ATP 2.39726
57 5ZZ6 ADP 2.40385
58 2EWM NAD 2.40964
59 2JAH NDP 2.42915
60 2JAP NDP 2.42915
61 5XLX SAH 2.48227
62 5L95 AMP 2.50896
63 2HK9 ATR 2.54545
64 3A4T SFG 2.55474
65 6F9Q NAD 2.57353
66 3A27 SAM 2.57353
67 1GYY FHC 2.63158
68 5JJR SAH 2.6936
69 5YF1 8V0 2.6936
70 5YF1 SFG 2.6936
71 2P41 SAH 2.6936
72 4UZI IMD 2.6936
73 2YX1 SFG 2.6936
74 3P9C SAH 2.6936
75 2F5X ASP 2.6936
76 6EL3 NAP 2.6936
77 4HXY NDP 2.6936
78 4UFH GIF 2.6936
79 4WBD CIT 2.6936
80 2FR1 NDP 2.6936
81 5A3B APR 2.6936
82 3C6K MTA 2.6936
83 3C6K SPD 2.6936
84 1I8T FAD 2.6936
85 4J1Q NDP 2.6936
86 2HIM ASN 2.6936
87 3IIJ ADP 2.77778
88 2RIF AMP 2.83688
89 3EVG SAH 2.90909
90 4O0L NDP 2.90909
91 5CUQ NSC 2.99625
92 1V59 NAD 3.0303
93 2GN4 NDP 3.0303
94 2GN4 UD1 3.0303
95 4G5H NAP 3.0303
96 4G5H UD7 3.0303
97 2PT9 S4M 3.0303
98 2PT9 2MH 3.0303
99 5FJN BE2 3.0303
100 5FJN FAD 3.0303
101 1EU1 MGD 3.0303
102 3ABI NAD 3.0303
103 2V3V MGD 3.0303
104 3OID NDP 3.10078
105 4NBW NAD 3.11284
106 3WCS MAN NAG 3.14961
107 6DUB SAH 3.15315
108 4CS9 AMP 3.1746
109 2I7C AAT 3.18021
110 3ZV6 4HB 3.20285
111 3ZV6 NAD 3.20285
112 2BGM NAJ 3.23741
113 1BDB NAD 3.2491
114 1AE1 NAP 3.2967
115 1UAY ADN 3.30579
116 3QOX SAH 3.367
117 5MW4 5JU 3.367
118 5ICE 2H4 3.367
119 5ICE SAH 3.367
120 3FPF TNA 3.367
121 3FPF MTA 3.367
122 3L9W AMP 3.367
123 3L9W GSH 3.367
124 5BJX NAD 3.367
125 5BJX UDP 3.367
126 3A25 SAM 3.367
127 5MLR NAP 3.367
128 5MLR GRQ 3.367
129 1DMR PGD 3.367
130 3UCL CYH 3.367
131 3UCL NAP 3.367
132 3UCL FAD 3.367
133 1IY8 NAD 3.37079
134 3C3Y SAH 3.37553
135 5U32 GDP 3.38983
136 5EW0 3C7 3.4188
137 3A4M ADP 3.46154
138 3MB5 SAM 3.52941
139 5ZW3 SAH 3.55556
140 3NDJ SAH 3.7037
141 3NDJ JHZ 3.7037
142 2EJU SAH 3.7037
143 5HJM MTA 3.7037
144 4Y9D NAI 3.7037
145 1YBH FAD 3.7037
146 3VYW SAM 3.7037
147 1ELI PYC 3.7037
148 2IV2 MGD 3.7037
149 2IV2 2MD 3.7037
150 5O2N FLC 3.7037
151 5DF1 58X 3.7037
152 5DF1 NAP 3.7037
153 1PL6 NAD 3.7037
154 2Q28 ADP 3.7037
155 1JQ3 AAT 3.71622
156 4U36 TNR 3.75
157 3CH6 NAP 3.84615
158 3CH6 311 3.84615
159 5YJI SAH 3.87324
160 5YJI 8WO 3.87324
161 1NJR XYL 3.87324
162 1XG5 NAP 3.94265
163 4YUW 4JU 3.94737
164 4YUW S4M 3.94737
165 6GFK SAH 3.98406
166 3FZG SAM 4
167 4POO SAM 4
168 4NBU NAI 4
169 1N2X SAM 4.0404
170 3FSY SCA 4.0404
171 5WKC FAD 4.0404
172 1T9D P25 4.0404
173 1T9D FAD 4.0404
174 1T9D PYD 4.0404
175 1T9D 1MM 4.0404
176 1WVG APR 4.0404
177 1F8G NAD 4.0404
178 3G58 988 4.0404
179 2PX8 SAH 4.08922
180 4CQM NAP 4.09836
181 5KXE 6Y2 4.11523
182 3O03 NAP 4.12371
183 4Z7X 3CX 4.20168
184 5FTW SAH 4.29688
185 2RH4 EMO 4.33213
186 1ONI BEZ 4.34783
187 1O97 AMP 4.3771
188 1O97 FAD 4.3771
189 5JAQ NAI 4.3771
190 3MAG SAH 4.3771
191 1BW9 NAD 4.3771
192 2YY7 NAD 4.3771
193 3MCT SAH 4.3771
194 1PJS NAD 4.3771
195 1KNR FAD 4.3771
196 1P77 ATR 4.41176
197 6B92 SAH 4.42177
198 1BC5 SAH 4.46097
199 4QAR ADE 4.47761
200 4YSX FAD 4.48718
201 5XL4 SIA 4.54545
202 4L2I FAD 4.56274
203 2DPM SAM 4.57746
204 3GCZ SAM 4.60993
205 2EFJ SAH 4.7138
206 3ELW SAM 4.7138
207 3ELW GP3 4.7138
208 5F7J ADE 4.7138
209 1VHW ADN 4.74308
210 4JCA CIT 4.79042
211 3FUU ADN 4.79705
212 2UYQ SAM 4.83871
213 3NUG NAD 4.8583
214 5GT9 NAP 4.94297
215 1O5O U5P 4.97738
216 5E1M SAH 4.97925
217 5E1M PRO PRO LYS ARG ILE ALA 4.97925
218 3LE7 ADE 4.98084
219 3DXY SAM 5.04587
220 4LHD GLY 5.05051
221 4ONQ SFG 5.05051
222 1RJW ETF 5.05051
223 1UWK URO 5.05051
224 1UWK NAD 5.05051
225 1RZM E4P 5.05051
226 3RUV ANP 5.05051
227 4YNU LGC 5.05051
228 5FEU NAP 5.15464
229 1WG8 SAM 5.26316
230 5K7U SAM 5.33333
231 5E9W SAH 5.38721
232 2EG5 SAH 5.38721
233 5E8J SAH 5.38721
234 5X62 SAH 5.38721
235 3VSE SAH 5.38721
236 5ZYN FAD 5.38721
237 2JK0 ASP 5.38721
238 1FEC FAD 5.38721
239 2CHT TSA 5.51181
240 1XCL SAH 5.53191
241 2HMT NAI 5.55556
242 3Q87 SAM 5.6
243 5IL1 SAM 5.66038
244 2A14 SAH 5.70342
245 3BGD SAH 5.72391
246 1U2Z SAH 5.72391
247 3BGD PM6 5.72391
248 3SSO SAH 5.72391
249 3WMX NAD 5.72391
250 4YDD MD1 5.72391
251 4YDD MGD 5.72391
252 2OOR NAD 5.74713
253 2WA2 SAM 5.7971
254 5FFF 5XC 5.83658
255 5FFF NAP 5.83658
256 1EFV FAD 5.88235
257 1EFV AMP 5.88235
258 4FN4 NAD 5.90551
259 4WOH 4NP 6.0241
260 3CBG SAH 6.03448
261 3G2O SAM 6.06061
262 2V6G NAP 6.06061
263 2ZXI FAD 6.06061
264 1BXK NAD 6.06061
265 2E5V FAD 6.06061
266 1P31 EPU 6.06061
267 2C31 TZD 6.06061
268 2C31 ADP 6.06061
269 2IVF MGD 6.07477
270 3ZVS MLI 6.25
271 3BY8 MLT 6.33803
272 5XNC MTA 6.39731
273 4PIO AVI 6.39731
274 4PIO SAH 6.39731
275 4D5G TPP 6.39731
276 4D5G FAD 6.39731
277 3GEG NAD 6.47773
278 4YAG NAI 6.57439
279 3I53 SAH 6.73401
280 2JJQ SAH 6.73401
281 5YEC ATP 6.73401
282 2E7Z MGD 6.73401
283 1T36 U 6.73401
284 1G8K MGD 6.76692
285 1JG3 ADN 6.80851
286 3EVF SAH 6.85921
287 3EVF GTA 6.85921
288 2VT3 ATP 6.97674
289 5THQ NDP 6.98529
290 5OVK NDP 7.03125
291 5FUB SAH 7.07071
292 4FZV SAM 7.07071
293 5FA5 MTA 7.07071
294 4X60 SFG 7.07071
295 4X60 3XV 7.07071
296 4GQB 0XU 7.07071
297 4DMG SAM 7.07071
298 4YAC NAI 7.07071
299 5AEW BNL 7.07071
300 4BLW AMP 7.26644
301 4BLW SAH 7.26644
302 1TZD ADP 7.27273
303 4COQ SAN 7.28745
304 6CI9 NAP 7.33591
305 3OFK SAH 7.40741
306 6D6Y SAH 7.40741
307 4RSL FAD 7.40741
308 1I1N SAH 7.52212
309 2OBF F83 7.61246
310 2OBF SAH 7.61246
311 1G60 SAM 7.69231
312 1G55 SAH 7.74411
313 3WCZ CIT 7.74411
314 1X87 NAD 7.74411
315 2ZIF SAM 7.74411
316 3TKA SAM 7.74411
317 1NVM NAD 7.74411
318 2WSB NAD 7.74411
319 1QAN SAH 7.78689
320 1ZK4 NAP 7.96813
321 3G89 SAM 8.03213
322 5W7K SAH 8.08081
323 4C4A SAH 8.08081
324 1Q0S SAH 8.10811
325 4IF4 BEF 8.17308
326 2BD0 NAP 8.19672
327 3D3W NAP 8.19672
328 1PR9 NAP 8.19672
329 3K8D KDO 8.33333
330 4RDH AMP 8.33333
331 4RDI ATP 8.33333
332 4IWN GEK 8.41751
333 5KOK SAH 8.41751
334 5KOK S9T 8.41751
335 5KOK R9T 8.41751
336 2IZ1 ATR 8.41751
337 3K6V CIT 8.41751
338 2NV2 GLN 8.5034
339 2BZG SAH 8.62069
340 3PT9 SAH 8.75421
341 5ERG SAM 8.75421
342 6BQ6 TER 8.76133
343 5ZZO FLC 8.95522
344 2XYQ SAH 8.96552
345 3DUW SAH 8.96861
346 3QVL 5HY 8.97959
347 2ZWA SAH 9.09091
348 1RJD SAM 9.09091
349 1Y8Q ATP 9.09091
350 1KQF MGD 9.18367
351 4GKV NAD 9.22619
352 1VL8 NAP 9.3633
353 5DLY 5D7 9.3985
354 5DLY SAH 9.3985
355 3X0D SAH 9.42761
356 1R27 MGD 9.42761
357 2O07 SPD 9.42761
358 2O07 MTA 9.42761
359 1PN0 IPH 9.42761
360 1PN0 FAD 9.42761
361 1XKQ NDP 9.64286
362 1TE2 PGA 9.73451
363 5DM1 SAH 9.73783
364 5DM1 5D7 9.73783
365 4KGD FAD 9.76431
366 4KGD TDP 9.76431
367 6DEN TP9 9.76431
368 6DEN FAD 9.76431
369 6DEN G8A 9.76431
370 1E5Q NDP 9.76431
371 2FKA BEF 10.0775
372 4M73 SAH 10.101
373 4M73 M72 10.101
374 1XHL NDP 10.101
375 2CDU ADP 10.101
376 1WY7 SAH 10.1449
377 4D79 ATP 10.1449
378 3FGZ BEF 10.1562
379 5I8F ML1 10.303
380 1ZQ9 SAM 10.5263
381 4JX1 CAH 10.6195
382 2NXE SAM 10.6299
383 1Z3C SA8 10.7744
384 1KPG SAH 10.8014
385 5O42 9JW 10.9489
386 5O42 BGC 10.9489
387 5O42 NAD 10.9489
388 5FWA J7C 11.1111
389 4UCI SAM 11.1111
390 3QWI NAP 11.1111
391 3QWI CUE 11.1111
392 1SB8 UD2 11.1111
393 1SB8 NAD 11.1111
394 1KPH SAH 11.1498
395 5FH7 5XL 11.2903
396 2FK8 SAM 11.4478
397 3RKR NAP 11.4504
398 1NFQ NAI 11.5385
399 5THY SAH 11.8519
400 1R18 SAH 11.8943
401 4XUC 43G 11.9266
402 4XUC SAM 11.9266
403 5TVI O8N 11.9565
404 3GDH SAH 12.0332
405 5THZ SAH 12.0988
406 3U4C NDP 12.0996
407 3TLJ SAH 12.1212
408 1QO8 FAD 12.1212
409 3HVJ 705 12.2172
410 3O7W SAM 12.2449
411 6F4W FMC 12.4464
412 3TKY SAH 12.4579
413 4A6D SAM 12.4579
414 5W7R SAH 12.4579
415 5W7R 9Z7 12.4579
416 1NW4 IMH 12.6812
417 2VDV SAM 12.7946
418 4M37 SAH 13.1313
419 3S1S SAH 13.1313
420 4DCM SAM 13.1313
421 4M38 SAH 13.1313
422 1V5F FAD 13.1313
423 1V5F TPP 13.1313
424 3FRH SAH 13.4387
425 5W7M SAH 13.468
426 3GWZ SAH 13.8047
427 3GXO SAH 13.8047
428 1DL5 SAH 13.8047
429 3EGI ADP 14.0777
430 5EEH P9P 14.8148
431 5EEH SAH 14.8148
432 4OBW SAM 15.1751
433 6GKV SAH 15.8249
434 6ARJ SAH 15.8249
435 6ARJ BW4 15.8249
436 5DX8 SFG 15.8249
437 5DXA SFG 15.8249
438 5DX1 SFG 15.8249
439 5DX0 SFG 15.8249
440 5DWQ SFG 15.8249
441 3GRU AMP 16.1616
442 1NV8 SAM 16.1972
443 1NV8 MEQ 16.1972
444 3VC1 SAH 16.4983
445 3VC1 GST 16.4983
446 3GU3 SAH 16.5493
447 4AZW SAM 16.835
448 4Y30 49L 16.835
449 4Y30 SAH 16.835
450 3R51 MMA 17.5
451 1IM8 SAI 17.623
452 3M6W SAM 18.1818
453 2AE2 PTO 18.4615
454 2AE2 NAP 18.4615
455 1KYZ SAH 18.5185
456 1QZZ SAM 18.5185
457 1KYZ FER 18.5185
458 1XDS SAM 19.2513
459 4II2 ATP 19.2771
460 5MPT SAH 19.5286
461 5GWX SAM 20.0704
462 5GWX SAR 20.0704
463 2PXX SAH 20.4651
464 4QTU SAM 21.1538
465 1P1C SAH 21.608
466 3DMH SAM 22.5589
467 3DMH GMP 22.5589
468 2CDN ADP 23.3831
469 3LCC SAH 23.8298
470 3JWH SAH 23.9631
471 2XVM SAH 24.1206
472 1VE3 SAM 24.6696
473 5MGZ SAH 25.4237
474 5M58 SAH 27.8261
475 1L1E SAH 27.8746
476 1TPY SAH 30.3136
477 5WP5 SAH 30.6397
478 5WP4 SAH 31.9865
479 4R6W PC 37.2093
480 4R6W SAH 37.2093
Pocket No.: 2; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 64
This union binding pocket(no: 2) in the query (biounit: 5gm1.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 4K26 SFF None
2 4K26 NDP None
3 3BJE URA 1.6835
4 2WD7 VGD 1.86567
5 5XH2 NPO 2.0202
6 4IEE AGS 2.0202
7 5EJ2 NAD 2.0202
8 4AQ4 G3P 2.0202
9 5WGR FAD 2.3569
10 4ZRN NAD 2.6936
11 4ZRN UPG 2.6936
12 3LU1 NAD 2.6936
13 1R6D NAD 2.6936
14 1R6D DAU 2.6936
15 1BZL GCG 3.0303
16 2R4J 13P 3.0303
17 2R4J FAD 3.0303
18 1BZL FAD 3.0303
19 5VN0 FAD 3.367
20 5VN0 NAI 3.367
21 1OAA OAA 3.861
22 4GNC ASO 4.0404
23 4WA2 SIA GAL NAG 4.0404
24 3QDX A2G GAL 4.1958
25 3QDT A2G GAL 4.1958
26 3TN7 NJP 4.28016
27 4NZ6 DLY 4.3771
28 2WPF WPF 4.3771
29 2WPF FAD 4.3771
30 4MO2 FDA 4.3771
31 4EZD SEY 4.3771
32 4CCW VKC 4.3771
33 1UDB UFG 4.7138
34 1UDB NAD 4.7138
35 1ORR NAD 4.7138
36 1GPJ CIT 5.05051
37 1XF1 CIT 5.72391
38 3ZIA ADP 5.7971
39 4DA6 GA2 5.92885
40 1GY8 NAD 6.06061
41 6BWL NAD 6.06061
42 5A9A UTP 6.39731
43 1XSE NDP 6.39731
44 3KIF GDL 6.60377
45 4E03 ADP 6.79612
46 2YLD CMO 7.08661
47 2CK3 ANP 7.40741
48 1REO FAD 7.40741
49 3GD8 GOL 7.62332
50 5M45 AMP 7.7381
51 2IID PHE 7.74411
52 2IID FAD 7.74411
53 4D04 FAD 7.74411
54 4D04 NAP 7.74411
55 1JT1 MCO 8.36502
56 1G2O IMH 8.95522
57 1EJH M7G 9.47368
58 5TS5 FAD 10.4377
59 3M89 GSP 10.5386
60 1O5I NAD 11.245
61 1L0I PSR 11.5385
62 1NW5 SAM 14.8148
63 1A5V Y3 16.4557
64 1Y7P RIP 21.5247
Pocket No.: 3; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 26
This union binding pocket(no: 3) in the query (biounit: 5gm1.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 2UYN 2KT None
2 2CBZ ATP 1.68776
3 5NM7 GLY 2.25564
4 3NV6 CAM 3.0303
5 1GZ6 NAI 3.0303
6 1ZBQ NAD 3.0303
7 4TWL ASC 3.0303
8 4LH7 1X8 3.0303
9 5GVR LMR 3.4188
10 1D1T NAD 4.0404
11 5Z2L NDP 4.08163
12 6HKE LMR 4.3771
13 1SQ5 ADP 4.7138
14 1JA9 NDP 4.74453
15 1V35 NAI 5.72391
16 4MCC 21X 6.09756
17 4ARE FLC 6.39731
18 1LVG ADP 6.56566
19 4JNA FAD 6.76471
20 1D4D SIN 8.41751
21 5XHA FRU 9.09091
22 1ZEI CRS 9.43396
23 5JBX COA 13.0268
24 5J47 6JJ 16.1616
25 2JB2 FAD 16.1616
26 2JB2 PHE 16.1616
Pocket No.: 4; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 11
This union binding pocket(no: 4) in the query (biounit: 5gm1.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 2BQP GLC 1.28205
2 2BWN SIN 2.0202
3 3C8F MT2 2.44898
4 5I39 FAD 3.7037
5 1RLZ NAD 4.0404
6 1MVQ MMA 4.23729
7 2F2U M77 5.05051
8 1TZJ A3B 5.05051
9 3SJU NDP 7.52688
10 5X2N ALA 12.8889
11 2GAG FAD 14.1414
Pocket No.: 5; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 23
This union binding pocket(no: 5) in the query (biounit: 5gm1.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 1AX2 NDG GAL 1.67364
2 3A4V NAD 2.0202
3 3BZ3 YAM 2.17391
4 3G5S FAD 2.6936
5 1MUU NAD 2.6936
6 4D86 ADP 3.0303
7 1IXI 2HP 3.7037
8 3N29 GOL 4.0404
9 2ZWI C5P 4.3771
10 5OC1 FAD 4.3771
11 3B6C SDN 4.70085
12 6BJO DUY 4.8
13 3I7S PYR 5.13699
14 3WQQ IB3 5.72391
15 3WQQ NDP 5.72391
16 1UKG MMA 5.95238
17 4L9Z OXL 6.73401
18 6ER9 FAD 7.40741
19 6ER9 NAP 7.40741
20 1W0J ADP BEF 7.40741
21 1J78 OLA 8.41751
22 5EXK 5AD 12.7946
23 5KAX RHQ 13.8554
Pocket No.: 6; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 18
This union binding pocket(no: 6) in the query (biounit: 5gm1.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 5K0A FAD 1.6835
2 6F5W KG1 2.6936
3 4YKG FAD 3.07102
4 4JBL MET 3.7037
5 3AYI HCI 4.0404
6 4C3Y FAD 5.05051
7 4C3Y ANB 5.05051
8 4YNU FAD 5.05051
9 5CGE 51F 5.41516
10 2CUL FAD 6.03448
11 5CX6 CDP 6.06061
12 1D4D FAD 8.41751
13 2AJH MET 8.67347
14 1XHL TNE 10.101
15 5JWC FAD 12.1212
16 2GAG FOA 14.1414
17 3AD8 PYC 17.1717
18 3AD8 FAD 17.1717
Pocket No.: 7; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 3
This union binding pocket(no: 7) in the query (biounit: 5gm1.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 1P7T PYR 3.0303
2 3EF0 ALF 3.7037
3 2AWN ADP 3.7037
Pocket No.: 8; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 6
This union binding pocket(no: 8) in the query (biounit: 5gm1.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 4WNP 3RJ 2.43902
2 3DUV KDO 4.19847
3 1D6Z HY1 5.72391
4 1VAY AZA 7.31707
5 3H9R TAK 10.0917
6 2V7Q ADP 13.6364
Pocket No.: 9; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 7
This union binding pocket(no: 9) in the query (biounit: 5gm1.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 1UO4 PIH None
2 1LES GLC FRU 1.65746
3 3GGF GVD 3.7037
4 5TWB FAD 3.77907
5 4X5S AZM 3.87931
6 4OPC FDA 9.42761
7 4JX1 CAM 10.6195
Pocket No.: 10; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 8
This union binding pocket(no: 10) in the query (biounit: 5gm1.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 4RYV ZEA 2.58065
2 3WCS MAN NAG GAL 3.14961
3 1VRP IOM 3.367
4 3CQL NAG 4.11523
5 1YUM NCN 4.7138
6 3VSV XYP 5.72391
7 5T2U NAP 7.25806
8 2WG9 OCA 25.3846
Pocket No.: 11; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 4
This union binding pocket(no: 11) in the query (biounit: 5gm1.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 3FXU TSU 2.6936
2 1T5C ADP 2.6936
3 6HKE MLT 4.3771
4 3FC4 EDO 6.73401
Pocket No.: 12; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 4
This union binding pocket(no: 12) in the query (biounit: 5gm1.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 5A7Y SAH 0.673401
2 5K8P 6R8 1.6835
3 3TUR DGL 1.74216
4 5AHO TLA 2.3569
Pocket No.: 13; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 13) in the query (biounit: 5gm1.bio1) has 4 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 14; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 11
This union binding pocket(no: 14) in the query (biounit: 5gm1.bio3) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 5J60 FAD 1.6835
2 3WDM ADN 2.29885
3 4MIG G3F 2.6936
4 1MV8 NAD 2.6936
5 5TKL G3H 3.0303
6 3EWP APR 3.38983
7 1JJV ATP 3.39806
8 1RM0 NAI 3.56473
9 3AYI FAD 4.0404
10 3HDY GDU 4.3771
11 3HDY FAD 4.3771
Pocket No.: 15; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 5
This union binding pocket(no: 15) in the query (biounit: 5gm1.bio3) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 2V7O DRN 2.0202
2 1OBD AMP 4.0404
3 4QM7 GTP 4.09357
4 5OD2 GLC 8.75421
5 4BJ8 BTN 19.8413
Pocket No.: 16; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 15
This union binding pocket(no: 16) in the query (biounit: 5gm1.bio3) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 3BMO AX4 1.73611
2 3BMQ AX5 1.73611
3 4CM4 4NR 1.73611
4 3JQ8 DX3 1.73611
5 3JQB DX6 1.73611
6 2VN9 GVD 2.0202
7 5WBF LAC 2.22222
8 6GNF GLC 2.3569
9 5XIO ANP 2.6936
10 3LXI CAM 2.6936
11 3SJ7 NDP 4.3771
12 6DXS HJ7 5.38721
13 4DHL 0K7 8.41751
14 1XMY ROL 8.41751
15 2XRH NIO 9
Pocket No.: 17; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 6
This union binding pocket(no: 17) in the query (biounit: 5gm1.bio3) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 4UP4 GAL NAG 2.0202
2 1EX7 5GP 3.22581
3 3VSV XYS 5.72391
4 1CT9 GLN 8.41751
5 3GVL SLB SIA 9.09091
6 1JNR FAD 12.7946
Pocket No.: 18; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 4
This union binding pocket(no: 18) in the query (biounit: 5gm1.bio3) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 3KP6 SAL None
2 6CZ7 MGD 3.0303
3 4TQK NAG 3.0303
4 5DNC ASN 4.3771
Pocket No.: 19; Query (leader) PDB : 5GM1; Ligand: SAH; Similar sites found with APoc: 64
This union binding pocket(no: 19) in the query (biounit: 5gm1.bio3) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 6FHO FAD 1.3468
2 1VHT BA3 1.37615
3 4XQC 13D 1.6835
4 1KEW NAD 1.6835
5 3V1S 0LH 1.6835
6 1ODJ GMP 1.70213
7 2IVD FAD 2.3569
8 3LZW NAP 2.3569
9 5MIT NAP 2.3569
10 5MIT FAD 2.3569
11 5WUW NAP 2.43902
12 1Z34 2FD 2.55319
13 2NYA MGD 2.6936
14 6GAR FAD 2.6936
15 1EK6 NAI 2.6936
16 1EK6 UPG 2.6936
17 1H0H MGD 2.80374
18 2UVO NAG 2.92398
19 2UVO NDG 2.92398
20 1W8D NAP 2.98013
21 4MOP 2H5 3.0303
22 5N53 8NB 3.07692
23 1Z6Z NAP 3.19149
24 3X01 AMP 3.367
25 4EIP FAD 3.367
26 1RM0 D6P 3.56473
27 5BRT CH9 3.58362
28 5BRT FAD 3.58362
29 4NTD FAD 3.7037
30 1PL6 572 3.7037
31 2DT5 NAD 4.0404
32 3AXB FAD 4.0404
33 3AXB PRO 4.0404
34 1U3U BNF 4.0404
35 1U3U NAD 4.0404
36 1ZEM NAD 4.19847
37 5IFK HPA 4.3771
38 5NMX NAP 4.7138
39 5NMX FAD 4.7138
40 5UAO FAD 4.7138
41 5KOX RFP 4.7138
42 5KOX FAD 4.7138
43 2FPU HSO 5.11364
44 4B63 ORN 5.72391
45 4B63 NAP 5.72391
46 4B63 FAD 5.72391
47 3I73 ADP 6.39731
48 3AB1 FAD 6.94444
49 5BVA FAD 7.07071
50 3KLJ FAD 7.27273
51 1U3G ADP 7.40741
52 3S5W FAD 8.08081
53 5OJI NAP 8.46154
54 5OJI ISN 8.46154
55 1EYQ NAR 8.55856
56 3UCJ AZM 10.5727
57 3GMB FAD 10.7744
58 1VKO NAD 11.7845
59 3E1T FAD 12.7946
60 3HB5 NAP 13.8047
61 4J36 FAD 13.8047
62 4J36 1HR 13.8047
63 4Z24 FAD 15.1515
64 4BCN T9N 16.4983
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