Receptor
PDB id Resolution Class Description Source Keywords
5HIK 2.35 Å EC: 2.1.1.156 CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE F METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH S-ADENOSYLM METHANOHALOPHILUS PORTUCALENSIS FDF-1 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES (SAM OR ADMTASE) CLASS I MONOMETHYLATION OF GLYCINE AND SARCOSINE LIMITING ENZYME IN BETAINE BIOSYNTHESIS BETAINE-MEDIATED FINHIBITION TRANSFERASE
Ref.: STRUCTURAL ANALYSIS OF GLYCINE SARCOSINE N-METHYLTR FROM METHANOHALOPHILUS PORTUCALENSIS REVEALS MECHAN INSIGHTS INTO THE REGULATION OF METHYLTRANSFERASE A SCI REP V. 6 38071 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:304;
A:305;
A:303;
A:302;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
SAM A:301;
Valid;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5GWX 2.21 Å EC: 2.1.1.156 CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE F METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH S-ADENOSYLMA ND SARCOSINE METHANOHALOPHILUS PORTUCALENSIS FDF-1 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES SAM ADOMCLASS I MONOMETHYLATION GLYCINE SARCOSINE RATE-LIMITING EBETAINE BIOSYNTHESIS BETAINE-MEDIATED FEEDBACK INHIBITION TRANSFERASE
Ref.: STRUCTURAL ANALYSIS OF GLYCINE SARCOSINE N-METHYLTR FROM METHANOHALOPHILUS PORTUCALENSIS REVEALS MECHAN INSIGHTS INTO THE REGULATION OF METHYLTRANSFERASE A SCI REP V. 6 38071 2016
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5GWX - SAR C3 H7 N O2 CNCC(=O)O
2 5HIM - DMG C4 H9 N O2 CN(C)CC(=O....
3 5HIK - SAM C15 H22 N6 O5 S C[S@@+](CC....
4 5HIL - SAR C3 H7 N O2 CNCC(=O)O
5 5H02 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5GWX - SAR C3 H7 N O2 CNCC(=O)O
2 5HIM - DMG C4 H9 N O2 CN(C)CC(=O....
3 5HIK - SAM C15 H22 N6 O5 S C[S@@+](CC....
4 5HIL - SAR C3 H7 N O2 CNCC(=O)O
5 5H02 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5GWX - SAR C3 H7 N O2 CNCC(=O)O
2 5HIM - DMG C4 H9 N O2 CN(C)CC(=O....
3 5HIK - SAM C15 H22 N6 O5 S C[S@@+](CC....
4 5HIL - SAR C3 H7 N O2 CNCC(=O)O
5 5H02 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 192
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 XYA 0.565789 0.773333
9 ADN 0.565789 0.773333
10 RAB 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 AMP MG 0.511364 0.710843
25 5AL 0.510417 0.743902
26 VMS 0.510204 0.673913
27 54H 0.510204 0.673913
28 0UM 0.51 0.857143
29 A 0.505747 0.707317
30 AMP 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 DAL AMP 0.50505 0.765432
34 NVA LMS 0.504951 0.725275
35 K15 0.5 0.883117
36 6RE 0.5 0.78481
37 5AD 0.5 0.75
38 SSA 0.5 0.684783
39 SON 0.5 0.746988
40 SRP 0.5 0.746988
41 LSS 0.49505 0.706522
42 CA0 0.494624 0.714286
43 A12 0.494505 0.705882
44 AP2 0.494505 0.705882
45 ME8 0.490385 0.841463
46 5CA 0.49 0.684783
47 TSB 0.49 0.681319
48 53H 0.49 0.666667
49 ACP 0.489362 0.694118
50 5AS 0.48913 0.648936
51 ADP 0.48913 0.690476
52 A2D 0.488889 0.690476
53 J7C 0.488889 0.772152
54 ZAS 0.488636 0.769231
55 8QN 0.485149 0.743902
56 GAP 0.484536 0.73494
57 AN2 0.483871 0.682353
58 A3S 0.483871 0.813333
59 A7D 0.483871 0.851351
60 GJV 0.483516 0.775
61 SRA 0.483146 0.694118
62 LAD 0.480769 0.752941
63 KAA 0.480769 0.698925
64 GSU 0.480769 0.722222
65 AMO 0.480392 0.746988
66 DSZ 0.480392 0.703297
67 52H 0.48 0.666667
68 ADP MG 0.478723 0.702381
69 M33 0.478723 0.722892
70 MAO 0.478261 0.82716
71 BA3 0.478261 0.690476
72 AOC 0.477778 0.776316
73 DSH 0.477778 0.842105
74 NEC 0.477778 0.75
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 Y3J 0.47561 0.706667
78 G5A 0.474227 0.684783
79 A3T 0.473684 0.8
80 ADP BEF 0.473684 0.686047
81 BEF ADP 0.473684 0.686047
82 B4P 0.473118 0.690476
83 AP5 0.473118 0.690476
84 A3N 0.472527 0.766234
85 KB1 0.471698 0.833333
86 LEU LMS 0.471154 0.706522
87 APC 0.46875 0.705882
88 PRX 0.46875 0.73494
89 PAJ 0.466019 0.712644
90 4AD 0.466019 0.759036
91 RBY 0.463918 0.72619
92 ADP PO3 0.463918 0.728395
93 ADV 0.463918 0.72619
94 ADX 0.463158 0.666667
95 MHZ 0.463158 0.82716
96 AU1 0.463158 0.674419
97 YAP 0.462963 0.738095
98 TXA 0.462264 0.72619
99 NB8 0.462264 0.72093
100 A3G 0.461538 0.802632
101 VRT 0.459184 0.842105
102 ATP MG 0.459184 0.702381
103 YSA 0.458716 0.684783
104 XAH 0.458716 0.715909
105 50T 0.458333 0.682353
106 ATP 0.458333 0.690476
107 7D7 0.45679 0.723684
108 ANP MG 0.455446 0.678161
109 KH3 0.455357 0.871795
110 ACQ 0.454545 0.694118
111 AQP 0.453608 0.690476
112 5FA 0.453608 0.690476
113 AR6 0.453608 0.710843
114 APR 0.453608 0.710843
115 NSS 0.451923 0.703297
116 FA5 0.449541 0.746988
117 AGS 0.44898 0.678161
118 SAP 0.44898 0.678161
119 A5D 0.44898 0.789474
120 AD9 0.44898 0.674419
121 PTJ 0.448598 0.72093
122 YLB 0.448276 0.758621
123 YLP 0.447368 0.738636
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 TYR AMP 0.445455 0.746988
128 MYR AMP 0.444444 0.776471
129 3AM 0.444444 0.674699
130 OAD 0.443396 0.73494
131 2VA 0.443299 0.779221
132 OOB 0.442308 0.722892
133 S8M 0.442308 0.831169
134 ADP VO4 0.441176 0.702381
135 VO4 ADP 0.441176 0.702381
136 ANP 0.44 0.674419
137 TAT 0.44 0.686047
138 WAQ 0.439252 0.75
139 ARG AMP 0.438596 0.727273
140 YLC 0.435897 0.755814
141 AAT 0.435644 0.797468
142 3OD 0.435185 0.73494
143 1ZZ 0.435185 0.755814
144 NVA 2AD 0.434343 0.815789
145 DLL 0.433962 0.722892
146 00A 0.433962 0.689655
147 7MD 0.433628 0.715909
148 ATF 0.431373 0.666667
149 SO8 0.43 0.792208
150 3UK 0.429907 0.714286
151 A6D 0.429907 0.72619
152 5SV 0.428571 0.741176
153 AMP DBH 0.428571 0.714286
154 WSA 0.42735 0.692308
155 TYM 0.42735 0.746988
156 9SN 0.427273 0.681818
157 AHZ 0.426087 0.755814
158 A A 0.425926 0.710843
159 3NZ 0.425926 0.807692
160 P5A 0.425926 0.691489
161 PR8 0.425926 0.744186
162 A1R 0.424528 0.709302
163 2A5 0.424242 0.674419
164 7MC 0.423729 0.719101
165 7D5 0.422222 0.658824
166 FYA 0.422018 0.722892
167 JB6 0.422018 0.709302
168 AYB 0.421488 0.75
169 PLP AAD 0.419355 0.764045
170 A22 0.419048 0.682353
171 MAP 0.419048 0.659091
172 2AM 0.417582 0.666667
173 TAD 0.417391 0.712644
174 A3P 0.416667 0.686747
175 ADP BMA 0.416667 0.714286
176 25A 0.415094 0.690476
177 YLA 0.413223 0.719101
178 ADQ 0.411215 0.694118
179 48N 0.410256 0.72093
180 0XU 0.41 0.824324
181 NAD IBO 0.406504 0.717647
182 7D3 0.40625 0.643678
183 PAP 0.405941 0.678571
184 OVE 0.404255 0.662791
185 4UV 0.403509 0.697674
186 ALF ADP 3PG 0.403361 0.712644
187 AF3 ADP 3PG 0.403361 0.712644
188 LA8 ALF 3PG 0.403361 0.712644
189 3AD 0.402299 0.783784
190 CMP 0.402062 0.691358
191 2BA 0.402062 0.682927
192 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5GWX; Ligand: SAR; Similar sites found: 259
This union binding pocket(no: 1) in the query (biounit: 5gwx.bio1) has 28 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3S1S SAH 0.0001666 0.4409 1.40845
2 1L1E SAH 0.0005245 0.4535 1.76056
3 5MW4 5JU 0.0017 0.43202 1.76056
4 3QOX SAH 0.0006542 0.4208 1.76056
5 1KNR FAD 0.008537 0.40309 1.76056
6 3OFK SAH 0.0002104 0.46622 1.85185
7 2BD0 NAP 0.002812 0.41381 2.04918
8 1YY5 FAD 0.002292 0.43066 2.11268
9 1RSG FAD 0.002378 0.42805 2.11268
10 2ZIF SAM 0.0004818 0.41171 2.11268
11 4ZCC NAI 0.00861 0.41157 2.11268
12 4ZCC FAD 0.00861 0.41157 2.11268
13 4NTC FAD 0.007128 0.40729 2.11268
14 2WSB NAD 0.006657 0.40756 2.3622
15 3O7W SAM 0.0001422 0.41404 2.46479
16 3AYI HCI 0.008382 0.4136 2.46479
17 3AYI FAD 0.008047 0.4136 2.46479
18 4DCM SAM 0.0001952 0.40543 2.46479
19 3LCV SAM 0.00006684 0.45653 2.4911
20 3E1T FAD 0.006351 0.41125 2.53906
21 1XCL SAH 0.002275 0.41749 2.55319
22 5CUQ NSC 0.005902 0.40092 2.62172
23 3FRH SAH 0.000321 0.43335 2.7668
24 4M73 SAH 0.00003321 0.49697 2.8169
25 4M73 M72 0.00004026 0.49499 2.8169
26 1QZZ SAM 0.0003817 0.48272 2.8169
27 5HJM MTA 0.001062 0.44421 2.8169
28 3NDJ JHZ 0.001433 0.44111 2.8169
29 3NDJ SAH 0.001433 0.44111 2.8169
30 5MBX SP5 0.003356 0.43139 2.8169
31 5MBX FAD 0.003356 0.43139 2.8169
32 1ZQ9 SAM 0.0003431 0.41357 2.8169
33 3A4T SFG 0.0001128 0.47759 2.91971
34 4KRI SAH 0.00004333 0.45567 3.16901
35 1RJD SAM 0.0004265 0.41905 3.16901
36 3PT9 SAH 0.000707 0.4036 3.16901
37 3MQ2 SAH 0.00007994 0.50361 3.21101
38 4FC7 NAP 0.006877 0.40888 3.2491
39 4FC7 COA 0.006877 0.40888 3.2491
40 4POO SAM 0.0002676 0.43758 3.5
41 1P1C SAH 0.0005261 0.4254 3.51759
42 1XDS SAM 0.0000505 0.5245 3.52113
43 5KOK S9T 0.00003324 0.49398 3.52113
44 5KOK SAH 0.00002355 0.46017 3.52113
45 5KOK R9T 0.0002658 0.4562 3.52113
46 4ITU 1HS 0.003064 0.42348 3.52113
47 2YX1 SFG 0.00004951 0.42219 3.52113
48 4ITU NAI 0.002104 0.42014 3.52113
49 1KPG SAH 0.0007191 0.41652 3.52113
50 5G3U ITW 0.006837 0.41081 3.52113
51 5G3U FDA 0.005216 0.40989 3.52113
52 5TTJ FAD 0.006683 0.40749 3.52113
53 1PR9 NAP 0.005002 0.40502 3.52113
54 1XXR MAN 0.04095 0.40421 3.72671
55 3P2E SAH 0.00002839 0.46216 3.87324
56 1YXM ADE 0.003866 0.45257 3.87324
57 4DMG SAM 0.002479 0.4486 3.87324
58 4FZV SAM 0.0001089 0.43854 3.87324
59 1G55 SAH 0.0001986 0.42513 3.87324
60 4OPC PGT 0.01722 0.42264 3.87324
61 4OPC FDA 0.01515 0.42234 3.87324
62 5E9W SAH 0.00004271 0.42061 3.87324
63 4FN4 NAD 0.001707 0.41975 3.87324
64 2ZWA SAH 0.0006194 0.41882 3.87324
65 4D7E FAD 0.00544 0.407 3.87324
66 3D3W NAP 0.004439 0.40711 4.09836
67 5BW4 SAM 0.00005699 0.43867 4.11985
68 5F2K OCA 0.001404 0.42587 4.22535
69 5F2K SAH 0.001404 0.42587 4.22535
70 5BVA FAD 0.003087 0.42526 4.22535
71 1E1M NAP 0.004846 0.42378 4.22535
72 1E1M FAD 0.004846 0.42378 4.22535
73 1YKJ PHB 0.01629 0.40654 4.22535
74 1YKJ FAD 0.01629 0.40654 4.22535
75 1Y8Q ATP 0.003991 0.40649 4.22535
76 1R18 SAH 0.0001805 0.43546 4.40529
77 5DM1 SAH 0.00005872 0.48966 4.49438
78 5DM1 5D7 0.00006322 0.48966 4.49438
79 2A14 SAH 0.00005164 0.45931 4.56274
80 2E5V FAD 0.008272 0.40646 4.57746
81 2VVM FAD 0.009213 0.40172 4.57746
82 1Q0S SAH 0.000241 0.43946 4.6332
83 1JG3 ADN 0.0001392 0.42341 4.68085
84 1WY7 SAH 0.0006774 0.41186 4.83092
85 4AZT SAM 0.0001641 0.43006 4.92958
86 4AZW SAM 0.0002378 0.42886 4.92958
87 4LWP SAH 0.0002105 0.42218 4.92958
88 3TKY SAH 0.0003331 0.42169 4.92958
89 2YY7 NAD 0.004322 0.40507 4.92958
90 1NW5 SAM 0.0008524 0.40291 4.92958
91 2V3A FAD 0.008861 0.40044 4.92958
92 5FA8 SAM 0.0003972 0.42775 4.96894
93 4XUC 43G 0.0001304 0.47007 5.04587
94 4XUC SAM 0.0001304 0.47007 5.04587
95 4OBW SAM 0.00002757 0.51893 5.05837
96 2UYQ SAM 0.000193 0.52053 5.28169
97 3VYW SAM 0.0001843 0.47294 5.28169
98 5JGL SAM 0.0001159 0.43042 5.28169
99 3UCL NAP 0.02295 0.40293 5.28169
100 3UCL CYH 0.02247 0.40161 5.28169
101 3UCL FAD 0.02247 0.40161 5.28169
102 3FUU ADN 0.0003303 0.41771 5.53506
103 5ULP KB1 0.002421 0.40285 5.59701
104 3X0D SAH 0.0000654 0.44127 5.6338
105 2IID PHE 0.003737 0.42939 5.6338
106 2IID FAD 0.003737 0.42939 5.6338
107 5JJR SAH 0.003883 0.42312 5.6338
108 1YQZ FAD 0.007095 0.42031 5.6338
109 1UWK URO 0.006261 0.4133 5.6338
110 1UWK NAD 0.006261 0.4133 5.6338
111 5J60 FAD 0.007948 0.40437 5.6338
112 1ZMD FAD 0.0104 0.4014 5.6338
113 1DMR PGD 0.02569 0.40019 5.6338
114 3H2B SAH 0.0001242 0.43542 5.91133
115 2CDU FAD 0.004044 0.41224 5.98592
116 1I9G SAM 0.0001433 0.43472 6.07143
117 4KRG SAH 0.00003047 0.44953 6.33803
118 1H82 FAD 0.003698 0.43035 6.33803
119 1H82 GZZ 0.004481 0.43035 6.33803
120 5BUK FAD 0.005908 0.41347 6.33803
121 1XHC FAD 0.004735 0.40945 6.33803
122 4MO2 FDA 0.005582 0.40763 6.33803
123 4IV9 FAD 0.006867 0.407 6.33803
124 4MO2 FAD 0.00804 0.40218 6.33803
125 3T7S SAM 0.0002678 0.42285 6.34328
126 5DLY 5D7 0.0003798 0.45768 6.39098
127 5DLY SAH 0.0003311 0.45768 6.39098
128 2EJU SAH 0.0001052 0.49301 6.69014
129 3AD8 NAD 0.006603 0.40134 6.69014
130 1XTP SAI 0.0001223 0.4314 6.69291
131 3DUW SAH 0.00007823 0.43555 6.72646
132 1IM8 SAI 0.00008716 0.44525 6.96721
133 1JQD SAH 0.0001143 0.46625 7.04225
134 2EG5 SAH 0.0008671 0.46577 7.04225
135 1DL5 SAH 0.0004078 0.43958 7.04225
136 1JQD HSM 0.0004309 0.43864 7.04225
137 4KIB SAH 0.0001752 0.41775 7.04225
138 2AOT SAH 0.0001877 0.41575 7.04225
139 3UOY NAP 0.01853 0.40648 7.04225
140 3UOY FAD 0.01853 0.40648 7.04225
141 1PS9 FAD 0.001289 0.43805 7.30253
142 1G60 SAM 0.000223 0.42359 7.30769
143 2CUL FAD 0.0009927 0.43581 7.32759
144 3VC1 SAH 0.0000908 0.48446 7.39437
145 3VC1 GST 0.0000908 0.48446 7.39437
146 2JJQ SAH 0.00003067 0.43059 7.39437
147 4FWE FAD 0.003454 0.42228 7.39437
148 4HSU FAD 0.003672 0.42211 7.39437
149 4E70 N7I 0.003065 0.40968 7.39437
150 4YSX FAD 0.004472 0.4147 7.69231
151 4PIO AVI 0.0003287 0.4525 7.74648
152 4PIO SAH 0.0003558 0.4525 7.74648
153 5T67 JHZ 0.001461 0.43981 7.74648
154 3SSO SAH 0.001225 0.43789 7.74648
155 3GRU AMP 0.00049 0.42618 7.74648
156 2FK8 SAM 0.0003814 0.42246 7.74648
157 4C3Y FAD 0.003158 0.42194 7.74648
158 4C3Y ANB 0.004741 0.41926 7.74648
159 5T67 SAH 0.004265 0.41554 7.74648
160 2HQM FAD 0.00711 0.40828 7.74648
161 1BC5 SAH 0.00007141 0.45633 7.80669
162 5FTW SAH 0.00007859 0.48879 7.8125
163 5E1M SAH 0.0001068 0.47355 7.88382
164 5E1M PRO PRO LYS ARG ILE ALA 0.0001068 0.47355 7.88382
165 3BGD PM6 0.003426 0.40497 8.07692
166 2GAG NAD 0.008093 0.40103 8.08081
167 5THZ SAH 0.00002609 0.47307 8.09859
168 4M38 SAH 0.00002461 0.4609 8.09859
169 1N2X SAM 0.0005078 0.44637 8.09859
170 4C4A SAH 0.0001683 0.42822 8.09859
171 3A27 SAM 0.0002147 0.42254 8.09859
172 5DXA SFG 0.002146 0.42056 8.09859
173 5DX8 SFG 0.001725 0.40511 8.09859
174 5DX1 SFG 0.002721 0.40414 8.09859
175 5DX0 SFG 0.002828 0.40326 8.09859
176 3GXO SAH 0.0004593 0.40266 8.09859
177 5DWQ SFG 0.001746 0.40174 8.09859
178 3GWZ SAH 0.0005115 0.40106 8.09859
179 3JWH SAH 0.00000006131 0.50878 8.29493
180 2HNK SAH 0.000963 0.4053 8.3682
181 4ONQ SFG 0.001921 0.43677 8.4507
182 2Z3Y F2N 0.001691 0.4352 8.4507
183 4J36 FAD 0.002221 0.41919 8.4507
184 4J36 1HR 0.005618 0.41347 8.4507
185 3GDH SAH 0.0000804 0.4751 8.71369
186 3DMH GMP 0.0001635 0.4568 8.80282
187 3DMH SAM 0.00008075 0.4433 8.80282
188 5F8F SFG 0.00002676 0.44031 9.15493
189 4RDH AMP 0.01629 0.4016 9.15493
190 3DXY SAM 0.001191 0.4641 9.17431
191 1WG8 SAM 0.0005625 0.42612 9.50704
192 4RPL 3UC 0.006788 0.42572 9.50704
193 4RPL FAD 0.0082 0.42023 9.50704
194 1I8T FAD 0.003786 0.41665 9.50704
195 4YMH SAH 0.00005593 0.49512 9.58333
196 1I1N SAH 0.0003962 0.44172 9.73451
197 5X62 SAH 0.0001195 0.49566 9.85915
198 2OBF F83 0.0001822 0.47434 9.85915
199 2OBF SAH 0.0001822 0.47434 9.85915
200 5THY SAH 0.00002046 0.46739 9.85915
201 3G89 SAM 0.00002252 0.44065 10.0402
202 3EGI ADP 0.0003772 0.50689 10.1942
203 3TLJ SAH 0.0005714 0.44426 10.2113
204 5KVA SAM 0.001394 0.40219 10.4317
205 3EGV SAH 0.0002112 0.4844 10.6299
206 2NXE SAM 0.00006958 0.43411 10.6299
207 1NV8 SAM 0.0001737 0.45744 10.9155
208 1NV8 MEQ 0.0001575 0.45744 10.9155
209 3GD4 NAD 0.02478 0.40414 11.2676
210 5N5D SAM 0.000113 0.42995 11.5044
211 1QAN SAH 0.00004132 0.4959 11.8852
212 2JB2 PHE 0.005452 0.41114 11.9718
213 2JB2 FAD 0.005154 0.41114 11.9718
214 2VDV SAM 0.0002595 0.49069 12.1951
215 4Y2H SAH 0.0009027 0.44224 12.5
216 4Y2H 49K 0.001127 0.43828 12.5
217 1Z3C SA8 0.0001473 0.46189 12.6761
218 1F3L SAH 0.0009179 0.43935 12.6761
219 1L3I SAH 0.000771 0.42469 13.0208
220 3GU3 SAH 0.00002224 0.42703 13.0282
221 3I53 SAH 0.00141 0.40327 13.5542
222 2PXX SAH 0.00004019 0.45261 13.7324
223 5XLX SAH 0.0002221 0.42365 13.8298
224 1E6E FAD 0.00232 0.42206 14.0625
225 2F5Z FAD 0.009358 0.40422 14.0625
226 5M58 SAH 0.00002158 0.45994 14.3478
227 3QWI CUE 0.009978 0.40215 14.4444
228 4R6W SAH 0.0000269 0.45837 14.7887
229 1KPH SAH 0.0008821 0.41272 15.1408
230 5JCA NDP 0.01092 0.4135 15.493
231 5JCA FAD 0.005599 0.4126 15.493
232 2XVM SAH 0.000001583 0.47485 15.5779
233 4YRY NAD 0.003974 0.42747 15.5797
234 4YRY FAD 0.002917 0.42437 15.5797
235 5E8J SAH 0.00004314 0.52775 15.9091
236 3OU2 SAH 0.000004086 0.52241 16.5138
237 1TPY SAH 0.0007924 0.41441 17.6056
238 5XVQ SAH 0.0001407 0.46933 18.662
239 5XVK SAH 0.00009187 0.45352 19.0141
240 3LCC SAH 0.0007159 0.40065 20
241 5GM1 SAH 0.00009284 0.47677 20.0704
242 5MPT SAH 0.00002275 0.45539 20.0704
243 5MGZ SAH 0.00001594 0.46506 20.339
244 1SQF SAM 0.00005175 0.44002 22.1831
245 5E72 SAM 0.0001824 0.43503 22.8873
246 3Q87 SAM 0.0002651 0.43354 23.5294
247 3PFG TLO 0.005642 0.43869 23.5741
248 3PFG SAM 0.005642 0.43869 23.5741
249 5LOG SAH 0.0003064 0.41812 24.4635
250 5JE0 AZ8 0.000005032 0.5218 25.1012
251 5JE0 SAH 0.000005032 0.5218 25.1012
252 4IWN GEK 0.000004043 0.5029 25.7642
253 1VE3 SAM 0.000005619 0.54972 26.4317
254 4QTU SAM 0.000006065 0.5422 26.9231
255 4NEC SAH 0.00009139 0.42313 28.0303
256 3HVJ 705 0.0002274 0.46434 28.0543
257 3BXO SAM 0.0000002289 0.50039 30.1255
258 3G2O SAM 0.000002912 0.49026 30.9859
259 4PNE SAH 0.0001195 0.44972 30.9859
Pocket No.: 2; Query (leader) PDB : 5GWX; Ligand: SAM; Similar sites found: 259
This union binding pocket(no: 2) in the query (biounit: 5gwx.bio1) has 28 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3S1S SAH 0.0001666 0.4409 1.40845
2 1L1E SAH 0.0005245 0.4535 1.76056
3 5MW4 5JU 0.0017 0.43202 1.76056
4 3QOX SAH 0.0006542 0.4208 1.76056
5 1KNR FAD 0.008537 0.40309 1.76056
6 3OFK SAH 0.0002104 0.46622 1.85185
7 2BD0 NAP 0.002812 0.41381 2.04918
8 1YY5 FAD 0.002292 0.43066 2.11268
9 1RSG FAD 0.002378 0.42805 2.11268
10 2ZIF SAM 0.0004818 0.41171 2.11268
11 4ZCC NAI 0.00861 0.41157 2.11268
12 4ZCC FAD 0.00861 0.41157 2.11268
13 4NTC FAD 0.007128 0.40729 2.11268
14 2WSB NAD 0.006657 0.40756 2.3622
15 3O7W SAM 0.0001422 0.41404 2.46479
16 3AYI HCI 0.008382 0.4136 2.46479
17 3AYI FAD 0.008047 0.4136 2.46479
18 4DCM SAM 0.0001952 0.40543 2.46479
19 3LCV SAM 0.00006684 0.45653 2.4911
20 3E1T FAD 0.006351 0.41125 2.53906
21 1XCL SAH 0.002275 0.41749 2.55319
22 5CUQ NSC 0.005902 0.40092 2.62172
23 3FRH SAH 0.000321 0.43335 2.7668
24 4M73 SAH 0.00003321 0.49697 2.8169
25 4M73 M72 0.00004026 0.49499 2.8169
26 1QZZ SAM 0.0003817 0.48272 2.8169
27 5HJM MTA 0.001062 0.44421 2.8169
28 3NDJ JHZ 0.001433 0.44111 2.8169
29 3NDJ SAH 0.001433 0.44111 2.8169
30 5MBX SP5 0.003356 0.43139 2.8169
31 5MBX FAD 0.003356 0.43139 2.8169
32 1ZQ9 SAM 0.0003431 0.41357 2.8169
33 3A4T SFG 0.0001128 0.47759 2.91971
34 4KRI SAH 0.00004333 0.45567 3.16901
35 1RJD SAM 0.0004265 0.41905 3.16901
36 3PT9 SAH 0.000707 0.4036 3.16901
37 3MQ2 SAH 0.00007994 0.50361 3.21101
38 4FC7 NAP 0.006877 0.40888 3.2491
39 4FC7 COA 0.006877 0.40888 3.2491
40 4POO SAM 0.0002676 0.43758 3.5
41 1P1C SAH 0.0005261 0.4254 3.51759
42 1XDS SAM 0.0000505 0.5245 3.52113
43 5KOK S9T 0.00003324 0.49398 3.52113
44 5KOK SAH 0.00002355 0.46017 3.52113
45 5KOK R9T 0.0002658 0.4562 3.52113
46 4ITU 1HS 0.003064 0.42348 3.52113
47 2YX1 SFG 0.00004951 0.42219 3.52113
48 4ITU NAI 0.002104 0.42014 3.52113
49 1KPG SAH 0.0007191 0.41652 3.52113
50 5G3U ITW 0.006837 0.41081 3.52113
51 5G3U FDA 0.005216 0.40989 3.52113
52 5TTJ FAD 0.006683 0.40749 3.52113
53 1PR9 NAP 0.005002 0.40502 3.52113
54 1XXR MAN 0.04095 0.40421 3.72671
55 3P2E SAH 0.00002839 0.46216 3.87324
56 1YXM ADE 0.003866 0.45257 3.87324
57 4DMG SAM 0.002479 0.4486 3.87324
58 4FZV SAM 0.0001089 0.43854 3.87324
59 1G55 SAH 0.0001986 0.42513 3.87324
60 4OPC PGT 0.01722 0.42264 3.87324
61 4OPC FDA 0.01515 0.42234 3.87324
62 5E9W SAH 0.00004271 0.42061 3.87324
63 4FN4 NAD 0.001707 0.41975 3.87324
64 2ZWA SAH 0.0006194 0.41882 3.87324
65 4D7E FAD 0.00544 0.407 3.87324
66 3D3W NAP 0.004439 0.40711 4.09836
67 5BW4 SAM 0.00005699 0.43867 4.11985
68 5F2K OCA 0.001404 0.42587 4.22535
69 5F2K SAH 0.001404 0.42587 4.22535
70 5BVA FAD 0.003087 0.42526 4.22535
71 1E1M NAP 0.004846 0.42378 4.22535
72 1E1M FAD 0.004846 0.42378 4.22535
73 1YKJ PHB 0.01629 0.40654 4.22535
74 1YKJ FAD 0.01629 0.40654 4.22535
75 1Y8Q ATP 0.003991 0.40649 4.22535
76 1R18 SAH 0.0001805 0.43546 4.40529
77 5DM1 SAH 0.00005872 0.48966 4.49438
78 5DM1 5D7 0.00006322 0.48966 4.49438
79 2A14 SAH 0.00005164 0.45931 4.56274
80 2E5V FAD 0.008272 0.40646 4.57746
81 2VVM FAD 0.009213 0.40172 4.57746
82 1Q0S SAH 0.000241 0.43946 4.6332
83 1JG3 ADN 0.0001392 0.42341 4.68085
84 1WY7 SAH 0.0006774 0.41186 4.83092
85 4AZT SAM 0.0001641 0.43006 4.92958
86 4AZW SAM 0.0002378 0.42886 4.92958
87 4LWP SAH 0.0002105 0.42218 4.92958
88 3TKY SAH 0.0003331 0.42169 4.92958
89 2YY7 NAD 0.004322 0.40507 4.92958
90 1NW5 SAM 0.0008524 0.40291 4.92958
91 2V3A FAD 0.008861 0.40044 4.92958
92 5FA8 SAM 0.0003972 0.42775 4.96894
93 4XUC 43G 0.0001304 0.47007 5.04587
94 4XUC SAM 0.0001304 0.47007 5.04587
95 4OBW SAM 0.00002757 0.51893 5.05837
96 2UYQ SAM 0.000193 0.52053 5.28169
97 3VYW SAM 0.0001843 0.47294 5.28169
98 5JGL SAM 0.0001159 0.43042 5.28169
99 3UCL NAP 0.02295 0.40293 5.28169
100 3UCL CYH 0.02247 0.40161 5.28169
101 3UCL FAD 0.02247 0.40161 5.28169
102 3FUU ADN 0.0003303 0.41771 5.53506
103 5ULP KB1 0.002421 0.40285 5.59701
104 3X0D SAH 0.0000654 0.44127 5.6338
105 2IID PHE 0.003737 0.42939 5.6338
106 2IID FAD 0.003737 0.42939 5.6338
107 5JJR SAH 0.003883 0.42312 5.6338
108 1YQZ FAD 0.007095 0.42031 5.6338
109 1UWK URO 0.006261 0.4133 5.6338
110 1UWK NAD 0.006261 0.4133 5.6338
111 5J60 FAD 0.007948 0.40437 5.6338
112 1ZMD FAD 0.0104 0.4014 5.6338
113 1DMR PGD 0.02569 0.40019 5.6338
114 3H2B SAH 0.0001242 0.43542 5.91133
115 2CDU FAD 0.004044 0.41224 5.98592
116 1I9G SAM 0.0001433 0.43472 6.07143
117 4KRG SAH 0.00003047 0.44953 6.33803
118 1H82 FAD 0.003698 0.43035 6.33803
119 1H82 GZZ 0.004481 0.43035 6.33803
120 5BUK FAD 0.005908 0.41347 6.33803
121 1XHC FAD 0.004735 0.40945 6.33803
122 4MO2 FDA 0.005582 0.40763 6.33803
123 4IV9 FAD 0.006867 0.407 6.33803
124 4MO2 FAD 0.00804 0.40218 6.33803
125 3T7S SAM 0.0002678 0.42285 6.34328
126 5DLY 5D7 0.0003798 0.45768 6.39098
127 5DLY SAH 0.0003311 0.45768 6.39098
128 2EJU SAH 0.0001052 0.49301 6.69014
129 3AD8 NAD 0.006603 0.40134 6.69014
130 1XTP SAI 0.0001223 0.4314 6.69291
131 3DUW SAH 0.00007823 0.43555 6.72646
132 1IM8 SAI 0.00008716 0.44525 6.96721
133 1JQD SAH 0.0001143 0.46625 7.04225
134 2EG5 SAH 0.0008671 0.46577 7.04225
135 1DL5 SAH 0.0004078 0.43958 7.04225
136 1JQD HSM 0.0004309 0.43864 7.04225
137 4KIB SAH 0.0001752 0.41775 7.04225
138 2AOT SAH 0.0001877 0.41575 7.04225
139 3UOY NAP 0.01853 0.40648 7.04225
140 3UOY FAD 0.01853 0.40648 7.04225
141 1PS9 FAD 0.001289 0.43805 7.30253
142 1G60 SAM 0.000223 0.42359 7.30769
143 2CUL FAD 0.0009927 0.43581 7.32759
144 3VC1 SAH 0.0000908 0.48446 7.39437
145 3VC1 GST 0.0000908 0.48446 7.39437
146 2JJQ SAH 0.00003067 0.43059 7.39437
147 4FWE FAD 0.003454 0.42228 7.39437
148 4HSU FAD 0.003672 0.42211 7.39437
149 4E70 N7I 0.003065 0.40968 7.39437
150 4YSX FAD 0.004472 0.4147 7.69231
151 4PIO AVI 0.0003287 0.4525 7.74648
152 4PIO SAH 0.0003558 0.4525 7.74648
153 5T67 JHZ 0.001461 0.43981 7.74648
154 3SSO SAH 0.001225 0.43789 7.74648
155 3GRU AMP 0.00049 0.42618 7.74648
156 2FK8 SAM 0.0003814 0.42246 7.74648
157 4C3Y FAD 0.003158 0.42194 7.74648
158 4C3Y ANB 0.004741 0.41926 7.74648
159 5T67 SAH 0.004265 0.41554 7.74648
160 2HQM FAD 0.00711 0.40828 7.74648
161 1BC5 SAH 0.00007141 0.45633 7.80669
162 5FTW SAH 0.00007859 0.48879 7.8125
163 5E1M SAH 0.0001068 0.47355 7.88382
164 5E1M PRO PRO LYS ARG ILE ALA 0.0001068 0.47355 7.88382
165 3BGD PM6 0.003426 0.40497 8.07692
166 2GAG NAD 0.008093 0.40103 8.08081
167 5THZ SAH 0.00002609 0.47307 8.09859
168 4M38 SAH 0.00002461 0.4609 8.09859
169 1N2X SAM 0.0005078 0.44637 8.09859
170 4C4A SAH 0.0001683 0.42822 8.09859
171 3A27 SAM 0.0002147 0.42254 8.09859
172 5DXA SFG 0.002146 0.42056 8.09859
173 5DX8 SFG 0.001725 0.40511 8.09859
174 5DX1 SFG 0.002721 0.40414 8.09859
175 5DX0 SFG 0.002828 0.40326 8.09859
176 3GXO SAH 0.0004593 0.40266 8.09859
177 5DWQ SFG 0.001746 0.40174 8.09859
178 3GWZ SAH 0.0005115 0.40106 8.09859
179 3JWH SAH 0.00000006131 0.50878 8.29493
180 2HNK SAH 0.000963 0.4053 8.3682
181 4ONQ SFG 0.001921 0.43677 8.4507
182 2Z3Y F2N 0.001691 0.4352 8.4507
183 4J36 FAD 0.002221 0.41919 8.4507
184 4J36 1HR 0.005618 0.41347 8.4507
185 3GDH SAH 0.0000804 0.4751 8.71369
186 3DMH GMP 0.0001635 0.4568 8.80282
187 3DMH SAM 0.00008075 0.4433 8.80282
188 5F8F SFG 0.00002676 0.44031 9.15493
189 4RDH AMP 0.01629 0.4016 9.15493
190 3DXY SAM 0.001191 0.4641 9.17431
191 1WG8 SAM 0.0005625 0.42612 9.50704
192 4RPL 3UC 0.006788 0.42572 9.50704
193 4RPL FAD 0.0082 0.42023 9.50704
194 1I8T FAD 0.003786 0.41665 9.50704
195 4YMH SAH 0.00005593 0.49512 9.58333
196 1I1N SAH 0.0003962 0.44172 9.73451
197 5X62 SAH 0.0001195 0.49566 9.85915
198 2OBF F83 0.0001822 0.47434 9.85915
199 2OBF SAH 0.0001822 0.47434 9.85915
200 5THY SAH 0.00002046 0.46739 9.85915
201 3G89 SAM 0.00002252 0.44065 10.0402
202 3EGI ADP 0.0003772 0.50689 10.1942
203 3TLJ SAH 0.0005714 0.44426 10.2113
204 5KVA SAM 0.001394 0.40219 10.4317
205 3EGV SAH 0.0002112 0.4844 10.6299
206 2NXE SAM 0.00006958 0.43411 10.6299
207 1NV8 SAM 0.0001737 0.45744 10.9155
208 1NV8 MEQ 0.0001575 0.45744 10.9155
209 3GD4 NAD 0.02478 0.40414 11.2676
210 5N5D SAM 0.000113 0.42995 11.5044
211 1QAN SAH 0.00004132 0.4959 11.8852
212 2JB2 PHE 0.005452 0.41114 11.9718
213 2JB2 FAD 0.005154 0.41114 11.9718
214 2VDV SAM 0.0002595 0.49069 12.1951
215 4Y2H SAH 0.0009027 0.44224 12.5
216 4Y2H 49K 0.001127 0.43828 12.5
217 1Z3C SA8 0.0001473 0.46189 12.6761
218 1F3L SAH 0.0009179 0.43935 12.6761
219 1L3I SAH 0.000771 0.42469 13.0208
220 3GU3 SAH 0.00002224 0.42703 13.0282
221 3I53 SAH 0.00141 0.40327 13.5542
222 2PXX SAH 0.00004019 0.45261 13.7324
223 5XLX SAH 0.0002221 0.42365 13.8298
224 1E6E FAD 0.00232 0.42206 14.0625
225 2F5Z FAD 0.009358 0.40422 14.0625
226 5M58 SAH 0.00002158 0.45994 14.3478
227 3QWI CUE 0.009978 0.40215 14.4444
228 4R6W SAH 0.0000269 0.45837 14.7887
229 1KPH SAH 0.0008821 0.41272 15.1408
230 5JCA NDP 0.01092 0.4135 15.493
231 5JCA FAD 0.005599 0.4126 15.493
232 2XVM SAH 0.000001583 0.47485 15.5779
233 4YRY NAD 0.003974 0.42747 15.5797
234 4YRY FAD 0.002917 0.42437 15.5797
235 5E8J SAH 0.00004314 0.52775 15.9091
236 3OU2 SAH 0.000004086 0.52241 16.5138
237 1TPY SAH 0.0007924 0.41441 17.6056
238 5XVQ SAH 0.0001407 0.46933 18.662
239 5XVK SAH 0.00009187 0.45352 19.0141
240 3LCC SAH 0.0007159 0.40065 20
241 5GM1 SAH 0.00009284 0.47677 20.0704
242 5MPT SAH 0.00002275 0.45539 20.0704
243 5MGZ SAH 0.00001594 0.46506 20.339
244 1SQF SAM 0.00005175 0.44002 22.1831
245 5E72 SAM 0.0001824 0.43503 22.8873
246 3Q87 SAM 0.0002651 0.43354 23.5294
247 3PFG TLO 0.005642 0.43869 23.5741
248 3PFG SAM 0.005642 0.43869 23.5741
249 5LOG SAH 0.0003064 0.41812 24.4635
250 5JE0 AZ8 0.000005032 0.5218 25.1012
251 5JE0 SAH 0.000005032 0.5218 25.1012
252 4IWN GEK 0.000004043 0.5029 25.7642
253 1VE3 SAM 0.000005619 0.54972 26.4317
254 4QTU SAM 0.000006065 0.5422 26.9231
255 4NEC SAH 0.00009139 0.42313 28.0303
256 3HVJ 705 0.0002274 0.46434 28.0543
257 3BXO SAM 0.0000002289 0.50039 30.1255
258 3G2O SAM 0.000002912 0.49026 30.9859
259 4PNE SAH 0.0001195 0.44972 30.9859
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