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Receptor
PDB id Resolution Class Description Source Keywords
5IZJ 1.85 Å EC: 2.7.11.11 COMPLEX OF PKA WITH THE BISUBSTRATE PROTEIN KINASE INHIBITOR HOMO SAPIENS PROTEIN KINASE INHIBITOR BISUBSTRATE OLIGOARGININE PKA TRANSFERASE
Ref.: BIFUNCTIONAL LIGANDS FOR INHIBITION OF TIGHT-BINDIN PROTEIN-PROTEIN INTERACTIONS. BIOCONJUG.CHEM. V. 27 1900 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PO4 B:404;
A:402;
B:410;
A:412;
B:408;
A:413;
B:406;
B:403;
A:411;
A:404;
A:401;
A:407;
B:412;
F:102;
A:406;
B:407;
A:405;
B:405;
B:411;
A:408;
B:402;
A:409;
B:401;
A:403;
A:410;
B:409;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
94.971 O4 P [O-]P...
6J9 B:413;
A:414;
Valid;
Valid;
none;
none;
submit data
203.244 C10 H13 N5 c1c[n...
6J9 AZ1 DAR DAR DAR NH2 F:1;
Valid;
Atoms found LESS than expected: % Diff = 0;
submit data
845.072 n/a O=C([...
6J9 AZ1 DAR DAR NH2 G:1;
Valid;
none;
submit data
687.875 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1RE8 2.1 Å EC: 2.7.11.11 CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 2 MUS MUSCULUS PROTEIN KINASE NATURAL PRODUCT INHIBITOR LIGAND BINDING SPECIFICITY DETERMINANTS CONFORMATIONAL MALLEABILITY TRANSFERASE
Ref.: BALANOL ANALOGUES PROBE SPECIFICITY DETERMINANTS AND THE CONFORMATIONAL MALLEABILITY OF THE CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BIOCHEMISTRY V. 43 85 2004
Members (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 1REK Ki = 200 nM B8L C32 H36 N2 O7 CC[C@H](C)....
2 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
3 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
4 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
5 1SZM ic50 = 6.35 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
6 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
7 5IZJ - 6J9 C10 H13 N5 c1c[nH]c2c....
8 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 [H]/N=C(N)....
9 5IZF Kd = 1.7 nM 6J9 AZ1 DAR ACA DAR NH2 n/a n/a
70% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 1REK Ki = 200 nM B8L C32 H36 N2 O7 CC[C@H](C)....
2 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
3 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
4 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
5 1SZM ic50 = 6.35 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
6 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
7 5IZJ - 6J9 C10 H13 N5 c1c[nH]c2c....
8 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 [H]/N=C(N)....
9 5IZF Kd = 1.7 nM 6J9 AZ1 DAR ACA DAR NH2 n/a n/a
50% Homology Family (420)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 3IGO - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 3NCG - BK1 C19 H19 N5 CC(C)n1c2c....
3 3MWU - BK3 C22 H24 N6 c1ccc2c(c1....
4 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
5 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
6 6FCK ic50 = 0.031 uM D4Z C20 H22 N4 O c1ccc(cc1)....
7 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
8 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
9 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
10 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
11 5OQ7 ic50 = 0.8743 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
12 5F4N ic50 = 2.2 nM 5UY C17 H19 N7 O3 COC(=O)c1c....
13 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
14 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
15 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
16 5OP5 ic50 = 0.4964 uM 3FE C17 H15 N5 O c1cc(cc(c1....
17 3NLB ic50 = 35 nM 5BE C21 H28 N6 O Cc1c(c([nH....
18 3JVR Ki = 1.89 uM AGX C16 H13 Cl2 N3 O2 C[C@@H](c1....
19 2WMX ic50 = 0.86 uM ZY6 C17 H19 N5 O c1ccc(cc1)....
20 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
21 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
22 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
23 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
24 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
25 5OP7 - A1K C19 H21 Cl N6 O3 CNc1c2c(c[....
26 5OOP - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
27 5OPR ic50 = 5.8506 uM A3E C21 H26 N6 O CC(C)n1cc(....
28 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
29 5OQ5 ic50 = 0.052 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
30 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
31 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
32 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
33 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
34 5OQ8 ic50 = 4.0577 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
35 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
36 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
37 5OPS ic50 = 1.9827 uM A3Q C14 H9 N3 O c1cc(cc(c1....
38 3JVS Ki = 0.146 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
39 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
40 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
41 2C3L Ki = 0.026 uM IDZ C14 H10 N4 c1ccc2c(c1....
42 5OP2 ic50 = 0.5543 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
43 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
44 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
45 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
46 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
47 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 C[C@@]12[C....
48 5OOR - STU C28 H26 N4 O3 C[C@@]12[C....
49 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
50 4RVK ic50 = 13.5 nM 3XK C19 H13 N5 O CC(=O)Nc1c....
51 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
52 6FC8 ic50 = 0.012 uM D4Q C19 H19 F N4 O S c1cc(cc(c1....
53 3LFN Ki = 3160 nM A27 C23 H21 N3 O2 CCCC(=O)Nc....
54 3PY1 Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
55 2A4L ic50 = 0.4 uM RRC C19 H26 N6 O CC[C@H](CO....
56 1Y8Y ic50 = 2 uM CT7 C13 H11 Cl N4 O2 S CS(=O)(=O)....
57 6GUH Kd = 26 nM FB8 C18 H21 N5 O2 S Cc1ncc(n1C....
58 1OIR ic50 = 0.032 uM HDY C23 H26 N6 O2 Cc1c(n2ccc....
59 1PXJ - CK2 C9 H10 N4 S Cc1c(sc(n1....
60 2VTO ic50 = 0.14 uM LZ8 C17 H13 F N4 O2 c1ccc(cc1)....
61 2BTR ic50 = 95 nM U73 C13 H15 N3 O S CC(C)C1=CN....
62 2VTA ic50 = 185 uM LZ1 C7 H6 N2 c1ccc2c(c1....
63 3EZR - EZR C26 H27 N7 O CN1CCN(CC1....
64 3ULI ic50 = 0.07 uM 1N3 C21 H25 Br N6 O2 COc1ccc(cc....
65 2DS1 ic50 = 6.4 nM 1CD C22 H21 N5 O3 C[C@@H]1C[....
66 5FP5 - 1Y6 C7 H5 F O2 c1cc(ccc1C....
67 2VTH ic50 = 120 uM LZ2 C10 H9 N O3 S c1cc2c(ccc....
68 1KE5 ic50 = 560 nM LS1 C16 H15 N3 O3 S CNS(=O)(=O....
69 3FZ1 - B98 C13 H15 N3 O2 S COc1ccc2c(....
70 1WCC ic50 = 350 uM CIG C4 H4 Cl N3 c1c(nc(cn1....
71 1PXO Ki = 2 nM CK7 C14 H12 N6 O2 S Cc1c(sc(n1....
72 1H00 ic50 = 38 uM FAP C21 H23 F2 N5 O2 CN(C)C[C@@....
73 2R3R - 6SC C18 H14 Br N5 c1ccc(cc1)....
74 1B39 Kd = 0.12 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
75 3PXF Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
76 3TI1 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
77 2R3G ic50 = 800 nM SC9 C18 H14 F N5 c1ccc(c(c1....
78 2C69 ic50 = 26 uM CT8 C17 H14 Br N6 c1cc(cc(c1....
79 2VTM ic50 ~ 1 mM LZM C7 H4 N4 c1cnc2c(cn....
80 4ERW - STU C28 H26 N4 O3 C[C@@]12[C....
81 1E1V Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
82 2VV9 ic50 = 0.017 uM IM9 C23 H29 N7 O2 Cc1ncc(n1C....
83 5IEV - R0N C18 H23 F3 N4 O3 S C[C@H]([C@....
84 4D1X - ESJ C11 H8 N2 O3 S2 c1cc2c(cc1....
85 5MHQ - 8QT C19 H27 N7 O CC[C@@H]([....
86 2BTS ic50 = 20 nM U32 C12 H15 N3 O2 S2 CC(C)c1cnc....
87 1URW ic50 < 0.003 uM I1P C21 H24 N8 O2 S CN(C)CCCNS....
88 5FP6 - MFZ C11 H7 Cl2 N O c1cc(c2c(c....
89 1CKP - PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
90 1KE6 ic50 = 5.7 nM LS2 C17 H15 N5 O3 S2 CNS(=O)(=O....
91 2C6K ic50 = 0.73 uM DT2 C17 H21 N7 O2 S c1cc(ccc1N....
92 2R3Q - 5SC C19 H16 Br N5 O Cc1ccccc1c....
93 1OIT ic50 < 0.003 uM HDT C17 H14 N6 O2 S c1ccn2c(c1....
94 3NS9 ic50 = 0.003 uM NS9 C20 H27 N5 O3 CC(C)c1cnn....
95 1H01 ic50 = 22 uM FAL C21 H23 Cl2 N5 O2 CN(C)C[C@H....
96 2EXM - ZIP C10 H13 N5 CC(=CCNc1c....
97 4BGH ic50 = 4 nM 3I6 C13 H16 Br N5 O3 S C[C@H](CO)....
98 2R3F ic50 = 500 nM SC8 C18 H13 Cl2 N5 c1cc(c(c(c....
99 1GII - 1PU C17 H16 N4 O2 c1ccnc(c1)....
100 2R64 ic50 = 0.03 uM 740 C23 H27 N5 O3 S c1cc(ccc1C....
101 5A14 - LQ5 C24 H26 F3 N7 O2 CN1CCN(CC1....
102 2C6L ic50 = 0.27 uM DT4 C17 H22 N8 O2 S c1cc(ccc1N....
103 2W06 - FRV C18 H20 N6 O2 S Cc1ncc(n1C....
104 4EZ7 - STU C28 H26 N4 O3 C[C@@]12[C....
105 5D1J ic50 = 48 nM 56H C17 H24 N4 O2 S2 CC(C)(C)c1....
106 5IEY - 6AE C14 H19 N5 O3 S C[C@H]([C@....
107 2VTT ic50 = 0.044 uM LZD C16 H17 F2 N5 O2 c1cc(c(c(c....
108 2VU3 ic50 = 0.047 uM LZE C16 H17 Cl2 N5 O2 c1cc(c(c(c....
109 2B54 - D05 C20 H15 Cl3 N4 O3 CCc1c2c(n(....
110 1GZ8 - MBP C10 H13 N5 O2 CC(C)C(=O)....
111 3PY0 ic50 = 0.13 uM SU9 C13 H11 N3 O2 COc1ccc2c(....
112 2VTR ic50 = 1.5 uM LZB C10 H10 Cl N5 CC(C)Nc1cc....
113 1E1X Ki = 1.3 uM NW1 C11 H17 N5 O2 C1CCC(CC1)....
114 3UNJ ic50 = 11 uM 0BX C17 H14 N4 O2 c1ccc(cc1)....
115 2A0C - CK9 C19 H26 N6 O2 CC[C@H](CO....
116 3TIY - TIY C11 H8 O5 c1c2c(c(c(....
117 2R3I ic50 = 1000 nM SCF C18 H14 F N5 c1ccc(c(c1....
118 1VYZ ic50 = 290 nM N5B C13 H13 N3 O c1ccc(cc1)....
119 3WBL ic50 = 23 uM PDY C20 H26 N6 O CCOc1ccc(c....
120 4RJ3 ic50 = 93 nM 3QS C22 H28 N6 O COC1CCN(CC....
121 2VTN ic50 = 0.85 uM LZ7 C12 H11 F N4 O2 CC(=O)Nc1c....
122 1AQ1 - STU C28 H26 N4 O3 C[C@@]12[C....
123 2C6M ic50 = 0.35 uM DT5 C17 H20 N6 O3 S c1cc(ccc1N....
124 2R3L ic50 = 100 nM SCW C18 H14 Br N5 c1ccc(cc1)....
125 1H08 - BYP BWP n/a n/a
126 1B38 Kd = 0.254 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
127 2B52 ic50 = 8 nM D42 C21 H23 N7 O2 S Cc1c(sc(n1....
128 1PXL - CK4 C16 H13 F3 N4 S Cc1c(sc(n1....
129 3S2P ic50 = 0.068 uM PMU C17 H22 N4 O3 CC(C)c1cc(....
130 2R3O ic50 = 600 nM 2SC C19 H17 N5 O c1ccc(cc1)....
131 3IGG ic50 = 95 nM EFQ C16 H19 N3 O3 COc1ccc(cc....
132 1R78 ic50 = 3 nM FMD C20 H20 F N3 O4 C[C@H]([C@....
133 2FVD Ki = 0.003 uM LIA C18 H21 F2 N5 O4 S COc1ccc(c(....
134 2VTL ic50 = 97 uM LZ5 C10 H9 N3 O c1ccc(cc1)....
135 1KE9 ic50 = 660 nM LS5 C16 H15 N5 O3 S c1ccc2c(c1....
136 1PYE ic50 = 0.32 uM PM1 C21 H13 F2 N3 O2 c1ccc(cc1)....
137 4EZ3 - 0S0 C11 H10 N4 O4 S c1cc(ccc1/....
138 1H07 ic50 = 3 uM MFP C24 H27 Br N6 O2 Cc1ccc(c(c....
139 2B53 ic50 = 0.6 uM D23 C19 H19 F3 N4 CC(C)(C)Nc....
140 6GUK Kd = 725 nM FC8 C19 H24 Cl N7 CCn1cnc2c1....
141 2DUV ic50 = 0.087 uM 371 C19 H17 N O7 S Cc1cc2c(c(....
142 4D1Z - WG8 C13 H10 N2 O3 S c1cc2ccc(n....
143 4ACM Ki = 210 nM 7YG C20 H23 N7 O3 S CN(C)CCNS(....
144 2C5Y ic50 = 0.25 uM MTW C19 H15 N7 O2 c1cc(cc(c1....
145 2R3K ic50 = 100 nM SCQ C18 H14 Br N5 c1ccc(cc1)....
146 2V0D - C53 C9 H7 N3 O S [H]/N=C1/N....
147 2W1H ic50 = 0.052 uM L0F C17 H13 N5 O c1ccc(cc1)....
148 1Y91 ic50 = 0.059 uM CT9 C23 H33 N7 O2 S CC(C)c1cnn....
149 4FII - ARG PRO LYS PRO LEU VAL ASP PRO n/a n/a
150 4NJD ic50 = 0.79 uM NJD C21 H20 N8 O COc1nc(nc(....
151 4JDK - ARG ARG ARG ARG SER TRP TYR n/a n/a
152 5XVG Ki = 0.009 uM 8FX C20 H22 Cl N7 O C[C@@H]1CN....
153 2ZV2 - 609 C19 H10 N2 O3 c1ccc2c(c1....
154 4ONA ic50 = 0.002 uM UW1 C19 H23 N5 O2 CCOc1ccc2c....
155 4JBV ic50 = 0.003 uM V68 C26 H32 N6 O CC(C)COc1c....
156 3NYV - DTQ C16 H15 N3 O3 COc1cc2c(c....
157 3T3U Ki = 0.0025 uM BK6 C22 H24 N6 O COc1ccc2cc....
158 3KU2 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
159 4M84 ic50 = 0.049 uM 21E C17 H19 N5 O CC(C)(C)n1....
160 3HX4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
161 3UPX Ki = 0.0075 uM B6A C20 H22 N4 O c1ccc(cc1)....
162 3SXF Ki = 0.0025 uM BK5 C20 H21 N5 O CCOc1ccc2c....
163 3T3V Ki = 0.003 uM BK4 C19 H19 N5 O CC(C)n1c2c....
164 3I7B ic50 = 0.066 uM BK1 C19 H19 N5 CC(C)n1c2c....
165 3V5P Ki = 0.011 uM C88 C19 H24 N6 O Cc1cc(ccc1....
166 3V51 - I76 C25 H22 Cl N5 O CC(C)n1c2c....
167 3UPZ - B5A C11 H16 N6 c1c2c(ncnc....
168 3I7C ic50 = 0.018 uM BK2 C19 H19 N5 CC(C)(C)n1....
169 3V5T - UW9 C24 H30 N6 O CCOc1ccc2c....
170 3N51 - BK3 C22 H24 N6 c1ccc2c(c1....
171 5OTO - AQW C24 H23 Cl2 N3 CCc1ccccc1....
172 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
173 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
174 6EII - B5W C22 H23 Cl N c1ccc(cc1)....
175 5CU0 - 54R C18 H21 Cl N2 O CC(=O)NCCC....
176 5H8E ic50 < 0.003 uM 5Y3 C21 H25 N9 O CC(=O)Nc1c....
177 5OWH - B0K C10 H9 Br4 N3 c1nc2c(n1C....
178 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
179 5MOE Kd = 500 uM OQC C11 H10 Cl N O c1cc(c(cc1....
180 5OUE - AVZ C18 H19 Cl N3 c1ccc(cc1)....
181 5MOD Kd = 300 uM 86L C10 H14 Cl N O CC(C)Oc1cc....
182 5OWL - B0K C10 H9 Br4 N3 c1nc2c(n1C....
183 5CU3 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
184 5OTR - AU8 C13 H12 Cl2 N c1ccc(cc1)....
185 4KWP Ki = 0.04 uM EXX C12 H10 Br4 N2 O3 c1nc2c(n1[....
186 5OSL - A9K C13 H12 Cl N O c1ccc(c(c1....
187 5N9N Ki = 0.4 nM KC5 C20 H15 Cl2 N O4 COc1ccc(cc....
188 5CSP Kd = 58 uM 54G C8 H8 O3 Cc1ccc(c(c....
189 5CTP - 54R C18 H21 Cl N2 O CC(=O)NCCC....
190 5MOW - BR9 C5 H6 Br N3 c1c(cnc(c1....
191 4UB7 Ki = 2.5 nM 3G5 C16 H8 Br2 O5 c1cc(ccc1C....
192 5MMF - JMB C16 H19 Cl N CCC[NH2+]C....
193 5OTH - AQ8 C25 H26 Cl N3 O CCc1ccccc1....
194 1PJK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
195 3NSZ - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
196 5OTI - AOK C25 H26 Cl N3 CCc1ccccc1....
197 3AXW - TID C9 H7 N3 O2 S c1cc(ccc1c....
198 5MO6 - KXZ C19 H21 Cl N2 O3 c1ccc(cc1)....
199 2PVR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
200 3C13 - EMO C15 H10 O5 Cc1cc2c(c(....
201 5CS6 Kd = 630 uM K82 C10 H14 Cl N O CCCOc1ccc(....
202 3PE2 Ki = 0.175 nM E1B C20 H12 N4 O2 C#Cc1cccc(....
203 5CT0 - 54P C16 H18 Cl N O c1ccc(cc1)....
204 5CU6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
205 5M4C - 7EY C16 H14 N2 O2 S2 Cc1ccc(cc1....
206 5MO7 - YRA C16 H17 Cl N2 O c1ccc(cc1)....
207 5N9L Ki = 15 nM 8QH C20 H15 Cl2 N O3 Cc1ccc(cc1....
208 5OT5 - AWK C25 H26 Cl N3 CCc1ccccc1....
209 3OWK ic50 = 1.5 uM 18E C16 H11 Cl N2 O Cc1cnc(c2c....
210 5MMR - H83 C17 H21 Cl N2 c1ccc(cc1)....
211 5MPJ - J2P C15 H17 Cl N CC[NH2+]Cc....
212 5OQU - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
213 6GIH - EZN C15 H13 Cl N2 c1cc(c2cc[....
214 5CSV - GAB C7 H7 N O2 c1cc(cc(c1....
215 5MOT - HBD C7 H7 N O2 c1cc(ccc1C....
216 3R0T ic50 = 0.91 nM FU9 C22 H16 F3 N5 O2 c1cc(cc(c1....
217 3PE1 Ki = 0.38 nM 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
218 3JUH - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
219 5CLP - 42J C8 H9 Cl2 N c1cc(c(cc1....
220 5ORH Kd = 41 uM A4N C14 H14 Cl N Cc1ccccc1c....
221 3H30 Ki = 29.2 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
222 2ZJW ic50 = 0.04 uM REF C14 H6 O8 c1c2c-3c(c....
223 5OSZ - AHK C24 H25 Cl N3 CCc1ccccc1....
224 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
225 5OT6 - AJK C19 H20 Cl N2 c1ccc(cc1)....
226 6EHK - AUW C24 H23 Cl2 N3 CCc1ccccc1....
227 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
228 5OS8 - J27 C14 H14 Cl F N Cc1cc(ccc1....
229 5OTY - AUW C24 H23 Cl2 N3 CCc1ccccc1....
230 5OTD - AOW C24 H24 Cl N4 O2 CCc1ccccc1....
231 6GMD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
232 5CVF - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
233 5CX9 - 551 C20 H23 Cl N2 O3 COC(=O)CC(....
234 5OUL - AWE C13 H11 Cl F N c1cc(cc(c1....
235 3SHE - I85 C24 H22 F3 N5 O2 c1cc(cc(c1....
236 5IZJ - 6J9 C10 H13 N5 c1c[nH]c2c....
237 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 [H]/N=C(N)....
238 5IZF Kd = 1.7 nM 6J9 AZ1 DAR ACA DAR NH2 n/a n/a
239 2VZ6 - FEF C20 H19 N3 O4 c1ccc2c(c1....
240 2Z7R ic50 = 3 nM STU C28 H26 N4 O3 C[C@@]12[C....
241 4J8M ic50 = 48 nM CJ5 C26 H25 F3 N8 O c1cc(cc(c1....
242 5ORO - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
243 5OS4 Kd = 1665 uM A8H C14 H15 N O2 c1ccc(cc1)....
244 6HJJ ic50 = 1.7 uM G7T C26 H24 F4 N6 O2 Cc1cc(ccc1....
245 5ORS - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
246 5ORL - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
247 5DR9 - 5E2 C16 H9 Br Cl N O2 c1cc(cc(c1....
248 4DEA ic50 = 256 nM NHI C18 H14 N4 O4 c1cc(ccc1C....
249 5DN3 Kd = 3.77 uM 5DN C16 H9 Br F N O2 c1cc(cc(c1....
250 5ORP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
251 4DEE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
252 5OSE Kd = 681 uM A98 C6 H9 N3 O2 S2 CCSc1nnc(s....
253 5DNR - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
254 3UOD Kd = 49 nM 0C3 C18 H13 F3 N4 O2 c1ccc(c(c1....
255 3EFW - AK8 C25 H21 F3 N6 O2 Cc1cc(ccc1....
256 5DT0 - SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
257 3UO4 Kd = 299 nM 0C0 C23 H18 N4 O2 c1ccc(cc1)....
258 3UP2 Kd = 40 nM 0C8 C18 H13 F3 N4 O3 c1ccc(c(c1....
259 5ORX ic50 = 308 uM A6H C11 H8 Cl2 N2 O c1cc(c(c(c....
260 5ORN - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
261 5OS5 ic50 = 108 uM A8K C12 H10 O2 S c1cc(ccc1O....
262 5DR2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
263 3DJ5 - AK5 C21 H20 Br N5 O3 S COc1ccc(cc....
264 3UOL ic50 = 3.1 nM 0C7 C17 H13 Cl N8 c1ccc(c(c1....
265 3D14 ic50 = 22 nM AK1 C19 H15 F3 N6 O S2 c1cc(cc(c1....
266 5OSD - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
267 5OS2 Kd = 1821 uM A7K C13 H21 N2 O c1ccc(c(c1....
268 4BN1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
269 2NP8 ic50 = 42 nM CC3 C21 H18 F3 N5 O c1cc(cc(c1....
270 5ORR ic50 = 899 uM A5Q C9 H6 F3 N3 S c1cc(ccc1c....
271 4JBQ - VX6 C23 H28 N8 O S Cc1cc([nH]....
272 5OS3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
273 5DRD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
274 5DPV - SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
275 5ORZ ic50 = 245 uM A6W C10 H9 N O2 S2 COC(=O)c1c....
276 4UYN ic50 = 2 nM Y3M C25 H22 N4 O4 S CCOC(=O)c1....
277 5DT3 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
278 2WTV Ki = 1.8 nM ZZL C25 H15 Cl F2 N4 O2 c1cc(c(c(c....
279 6HJK ic50 = 25 nM G7W C25 H20 F4 N6 O2 CC(C)n1c2c....
280 3O50 - LJE C24 H17 F3 N4 O2 Cc1cc(ccc1....
281 2J4Z ic50 = 65 nM 626 C23 H24 N6 O2 S CN1CCN(CC1....
282 3LAU ic50 = 0.044 uM OFI C17 H17 N3 O2 CCCC(=O)Nc....
283 3DAJ ic50 = 2.9 uM FXG C22 H29 N7 O2 CCCCNC(=O)....
284 4JBO ic50 = 24 nM WPH C31 H32 N6 O3 CN(C)CCOc1....
285 5ORW Kd = 796 uM A6E C13 H16 F N O2 S c1cc(ccc1O....
286 2C6D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
287 5OS0 Kd = 2792 uM A6Z C12 H15 Cl N3 c1cc(cc(c1....
288 3K5U ic50 = 309 nM PFQ C20 H17 N3 O2 c1ccc(cc1)....
289 4KS7 - X4Z C25 H28 N8 O S Cc1nc2ccsc....
290 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
291 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
292 2OXY - K17 C7 H2 Br4 N2 c1[nH]c2c(....
293 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
294 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
295 1ZOE Ki = 0.04 uM K25 C9 H7 Br4 N3 CN(C)c1[nH....
296 2PVL Ki = 0.024 uM P55 C18 H20 N8 CCN1CCN(CC....
297 1LP4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
298 2PVN Ki = 0.00035 uM P63 C20 H16 N8 O CC(=O)Nc1c....
299 3KXG - K6X C7 H Br5 N2 c12c(c(c(c....
300 3BE9 Ki = 24 nM P04 C19 H21 N7 O c1cc2cc(c1....
301 2OXX - K22 C7 H2 Br4 N2 S c12c(c(c(c....
302 3KXM - K74 C11 H9 Br4 N3 O S CNC(=O)CSc....
303 1LR4 - BEN C7 H8 N2 [H]/N=C(c1....
304 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
305 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 C[N@@]1CCn....
306 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
307 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
308 3EH9 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
309 1IG1 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
310 5AUW ic50 = 8.9 uM QUE C15 H10 O7 c1cc(c(cc1....
311 5AV2 - KMP C15 H10 O6 c1cc(ccc1C....
312 5AUU ic50 = 21 uM LU2 C15 H10 O6 c1cc(c(cc1....
313 3EHA - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
314 5AV3 - KMP C15 H10 O6 c1cc(ccc1C....
315 5AUT Kd = 6.7 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
316 5AV0 ic50 = 280 uM 47X C15 H10 O5 c1cc(c(cc1....
317 1JKK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
318 3F5U - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
319 5AV4 - GEN C15 H10 O5 c1cc(ccc1C....
320 5AUX ic50 = 10 uM KMP C15 H10 O6 c1cc(ccc1C....
321 5AUV ic50 = 31 uM AGI C15 H10 O5 c1cc(ccc1C....
322 2XK6 - EQH C18 H21 N3 O2 S c1csc(c1C2....
323 2W5A - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
324 5M55 ic50 = 0.24 uM 7GG C17 H20 N6 CCN(CC)/C=....
325 2XNM ic50 = 0.16 uM WGZ C27 H27 F3 N4 O3 S C[C@H](c1c....
326 2XKF ic50 = 0.87 uM BX1 C19 H24 N4 O5 COc1cc(cc(....
327 2JAV ic50 ~ 8 uM 5Z5 C17 H16 Cl N3 O2 Cc1c([nH]c....
328 5M53 ic50 = 0.62 uM 7GJ C21 H26 N6 O2 CN(C)C(=O)....
329 2XK8 ic50 = 2.4 uM 5R1 C21 H21 N3 O6 COc1cc(ccc....
330 2WQO - VGK C21 H20 N2 O5 COc1cc(cc(....
331 2XKE ic50 = 4.2 uM WI2 C17 H20 N4 O3 COc1cccc(c....
332 2XNN - 430 C21 H16 F3 N3 O2 S C[C@H](c1c....
333 2XK7 ic50 = 1.5 uM 30E C21 H28 N4 O5 CC[C@H]1C[....
334 1Z5M ic50 = 30 nM LI8 C23 H31 Br N8 O3 CC(C)(C(=O....
335 5HKM ic50 = 0.013 uM 61Y C16 H15 N7 CCc1cc(nc(....
336 3QD0 ic50 = 0.00000001 M 3Q4 C24 H26 N8 O C[C@@H]1CC....
337 3ORZ - BI4 C27 H26 N4 O2 C[N@]1CCC[....
338 5LVN Kd = 20 uM ADN C10 H13 N5 O4 c1nc(c2c(n....
339 2XCH ic50 = 374 nM CKG C22 H25 N7 O c1c2c(nc(n....
340 4AW0 - MJF C18 H15 Cl O5 c1ccc(cc1)....
341 3OTU - BI4 C27 H26 N4 O2 C[N@]1CCC[....
342 3QCX ic50 = 0.00000001 M 3Q2 C16 H19 N7 O C[C@@H]1CO....
343 1UU3 ic50 = 0.75 uM LY4 C28 H28 N4 O3 CN(C)C[C@@....
344 5LVL Kd = 1.25 uM 537 C14 H8 N2 O c1ccc2c(c1....
345 3QC4 ic50 = 0.002 uM MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
346 3QCY ic50 = 0.00000001 M 3Q3 C22 H22 N8 O2 c1ccc(cc1)....
347 1UU8 ic50 = 9 uM BI1 C25 H24 N4 O2 CN(C)CCCn1....
348 4CT1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
349 4A07 - AZ7 C17 H13 Cl3 N2 O2 c1cc(ccc1[....
350 2X39 ic50 = 30 nM X39 C19 H21 Cl N6 O c1cc(ccc1C....
351 3E87 - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
352 4QNA ic50 = 0.023 uM X11 C9 H9 N5 O c1ccc(c(c1....
353 4QMO ic50 = 0.019 uM 34L C13 H8 N4 O S c1cc2c(c3c....
354 4QMW ic50 = 0.086 uM KS1 C17 H17 N7 c1c[nH]c2c....
355 3A7H - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
356 4QML - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
357 4QO9 ic50 = 0.16 uM 627 C26 H30 N6 O3 CN1CCN(CC1....
358 4QMQ ic50 = 0.26 uM 34U C24 H27 N5 O2 COCCOc1ccc....
359 4EL9 - AFE C21 H20 O10 C[C@H]1[C@....
360 5D9L ic50 = 0.024 uM 583 C15 H12 N2 O2 c1cc(ccc1c....
361 2XK9 ic50 = 0.03 nM XK9 C18 H17 N7 O4 C/C(=NNC(=....
362 2YCS ic50 = 1.36 nM NXP C18 H18 N6 O C/C(=NNC(=....
363 2WTI ic50 = 0.092 uM WTI C18 H15 N3 O3 S c1cc(ccc1c....
364 2YIR ic50 = 0.17 nM YIR C20 H19 N7 O3 [H]/N=C(N)....
365 2XBJ ic50 = 0.86 uM XBJ C23 H27 F N4 O4 CC(C)([C@@....
366 2XM9 ic50 = 0.009 uM LWH C21 H20 N6 O c1ccc2c(c1....
367 2YIQ ic50 = 12.67 nM YIQ C20 H19 N7 O C/C(=NNC(=....
368 2CN5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
369 3HZT - J60 C22 H27 Cl N4 O2 CCN(CC)CCN....
370 4FG8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
371 5L2S - 6ZV C27 H32 F2 N8 CCN1CCN(CC....
372 4AUA ic50 = 7.2 uM 4AU C12 H9 N3 O c1ccc2c(c1....
373 5K00 ic50 = 7.1 nM 6PV C32 H34 N6 O4 COc1cccc(c....
374 5MAG - 7KC C25 H30 N8 O S Cc1nc2ccsc....
375 5IHC ic50 = 0.013 uM 6BB C20 H21 F N4 O c1ccc(c(c1....
376 6BUU - GLY ARG PRO ARG THR THR ZXW PHE ALA GLU n/a n/a
377 3QKM ic50 = 0.038 uM SM9 C31 H43 N5 O4 S CCOCCN(C[C....
378 3CQU ic50 = 151 nM CQU C15 H13 N7 Cc1[nH]c(n....
379 2WEI ic50 = 3.4 nM VGG C17 H21 N5 Cc1cccc(c1....
380 3C0G - 3AM C10 H14 N5 O7 P c1nc(c2c(n....
381 3MFR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
382 4OTI ic50 = 43 nM MI1 C16 H20 N6 O C[C@@H]1CC....
383 3OFM - 4B0 C9 H7 Br4 N3 O C(Cn1c2c(c....
384 5YF9 - NIO C6 H5 N O2 c1cc(cnc1)....
385 5ONI - 9YE C23 H25 N O3 CC(C)n1c2c....
386 3WF7 ic50 = 206 nM FS9 C18 H17 F3 N6 O c1cc(cc(c1....
387 4L3J - 5FI C19 H21 F3 N6 CCc1cncnc1....
388 3WF6 ic50 = 33 nM FZ9 C18 H16 N6 c1ccc2c(c1....
389 4AU8 ic50 = 551 nM Z3R C11 H8 N2 O2 S3 c1ccc2c(c1....
390 6B16 Ki = 32 nM C7Y C19 H20 N8 C[C@@H](c1....
391 5DFP Ki = 22 nM 59U C28 H32 Cl N7 O CCN1c2c(cn....
392 3FXZ ic50 = 130 nM FLL C30 H18 Cl F N5 O4 Ru c1ccc(cc1)....
393 5IME Ki = 4.6 nM 6BZ C22 H22 Cl N7 O2 CC1=NC=CN(....
394 4ZY6 Ki = 5 nM 4T6 C18 H17 Cl N8 c1cc2c(c(c....
395 3Q53 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
396 4EQC ic50 = 0.008 uM XR1 C29 H28 Cl N7 O S CCN1c2c(cn....
397 5JZJ - AN2 C10 H16 N6 O9 P2 c1nc(c2c(n....
398 5AX9 ic50 = 8 nM 4KT C24 H24 N4 O3 COc1ccc(cc....
399 2J7T - 274 C28 H30 Cl N5 O4 S Cc1c([nH]c....
400 4JQE - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
401 4MWH - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
402 4LFI - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
403 3GGF - GVD C22 H19 N7 c1ccc2c(c1....
404 4U44 ic50 = 0.008 uM 3D9 C17 H13 N5 c1ccc(cc1)....
405 3DAK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
406 1QL6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
407 1PHK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
408 3M2W ic50 < 0.003 uM L8I C23 H21 F N4 O CN1CC2(C1)....
409 3BHY - 7CP C18 H18 Cl2 N4 O Cn1c2c(ccc....
410 2J90 - IZA C18 H16 F N3 O CC(C)(C)c1....
411 5VJA - DUK C14 H12 Cl N5 O2 S C[C@H](C(=....
412 5A6N ic50 = 2.1 uM U7E C7 H7 N5 O2 S c1cc(cc(c1....
413 6CMJ ic50 = 5 nM F6J C24 H22 N2 O2 CC(C)Cc1cc....
414 2VN9 - GVD C22 H19 N7 c1ccc2c(c1....
415 4EJN ic50 = 0.005 uM 0R4 C33 H26 F N7 O2 CC(=O)Nc1c....
416 4WNO ic50 = 160 nM 3RF C20 H19 N7 c1ccc2c(c1....
417 4WNP ic50 = 8 nM 3RJ C22 H20 N8 c1ccc2c(c1....
418 5CI7 ic50 = 120 nM 51W C18 H24 I N7 O c1cc(cc(c1....
419 2V7O - DRN C25 H23 N5 O2 S [H]/N=C(/N....
420 3AQV - TAK C24 H25 N5 O c1cc(ccc1c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 6J9; Similar ligands found: 7
No: Ligand ECFP6 Tc MDL keys Tc
1 6J9 1 1
2 5JT 0.532258 0.93617
3 M03 0.514286 0.796296
4 M05 0.492958 0.75
5 M04 0.479452 0.781818
6 X39 0.45 0.725806
7 0XZ 0.413793 0.652174
Ligand no: 2; Ligand: 6J9 AZ1 DAR DAR DAR NH2; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 6J9 AZ1 DAR DAR DAR NH2 1 1
2 6J9 AZ1 DAR DAR NH2 0.980198 1
3 6J9 AZ1 DAR ACA DAR NH2 0.830357 1
Ligand no: 3; Ligand: 6J9 AZ1 DAR DAR NH2; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 6J9 AZ1 DAR DAR NH2 1 1
2 6J9 AZ1 DAR DAR DAR NH2 0.980198 1
3 6J9 AZ1 DAR ACA DAR NH2 0.845455 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1RE8; Ligand: BD2; Similar sites found with APoc: 537
This union binding pocket(no: 1) in the query (biounit: 1re8.bio1) has 44 residues
No: Leader PDB Ligand Sequence Similarity
1 1RZX ACE VAL LYS GLU SER LEU VAL None
2 2RIF AMP None
3 3PN1 IVH 0.943396
4 4V03 ADP 1.16732
5 5EXK 5AD 1.20846
6 4U98 ACP 1.42857
7 3WXL ADP 1.42857
8 5KJW 53C 1.42857
9 6GH9 MIX 1.42857
10 1W0O SIA 1.42857
11 3ICS ADP 1.42857
12 3ICT ADP 1.42857
13 5DZ2 212 1.47929
14 4GLW 0XT 1.63934
15 5VLQ ANP 1.71429
16 6E8I PTR 1.77515
17 1TZD ADP 1.81818
18 3PNA CMP 1.94805
19 2YW2 ATP 2
20 5EQY 5RA 2
21 5JM8 ATP 2
22 3K5I ADP 2
23 6C1S EFV 2
24 3SHR CMP 2.00669
25 3MBI HSX 2.09059
26 4CC6 L5Y 2.20126
27 1G2O IMH 2.23881
28 3UDZ ADP 2.28571
29 6FL8 ADP 2.28571
30 6FL8 TIY 2.28571
31 5BU2 ADP 2.28571
32 1IOW ADP 2.28758
33 1IOW PHY 2.28758
34 5IGI GMP 2.32558
35 5IGI ZIT 2.32558
36 3I0O ADP 2.35988
37 2VDF OCT 2.37154
38 4WJT NAG 2.39521
39 5XQL C2E 2.4055
40 2CFM AMP 2.49554
41 2W68 SIA GAL BGC 2.5641
42 3AKK ADP 2.57143
43 3X01 AMP 2.57143
44 4PU5 ANP 2.57143
45 3ETH ATP 2.57143
46 1VRP ADP 2.57143
47 3EF0 ALF 2.57143
48 4YRI 4JH 2.57143
49 4M51 BEZ 2.57143
50 3IHG VAK 2.57143
51 3GXO MQA 2.57143
52 2I80 G1L 2.57143
53 2V58 LZJ 2.57143
54 4RYV ZEA 2.58065
55 3KYF 5GP 5GP 2.5974
56 5GZ9 ANP 2.62295
57 5COU ATP 2.64706
58 3TM0 ANP 2.6616
59 3TM0 B31 2.6616
60 1ZTH ADP 2.71318
61 1ZP9 ATP 2.71318
62 3RE4 TO1 2.71318
63 1T3D CYS 2.76817
64 4XJ6 GH3 2.85714
65 3HQP OXL 2.85714
66 5K2M ADP 2.9304
67 2IRY DGT 2.9703
68 3KYG 5GP 5GP 3.0837
69 2G30 ALA ALA PHE 3.10078
70 2AQX ATP 3.11419
71 3TII ANP 3.14286
72 1PK8 ATP 3.14286
73 2HGS ADP 3.14286
74 3UG4 AHR 3.14286
75 6EOM ALA LYS 3.14286
76 3KAL ADP 3.14286
77 5MW8 ATP 3.14286
78 1GT4 UNA 3.14465
79 3W0O ADP 3.15186
80 3W0O HY0 3.15186
81 4D4U FUC GAL NAG 3.1746
82 5TZO 7V7 3.19149
83 1A99 PUT 3.19767
84 4R78 AMP 3.23625
85 5D9G GLU ASN LEU TYR PHE GLN 3.25203
86 4Z1D PEP 3.26087
87 3FXU TSU 3.27869
88 3NOJ PYR 3.36134
89 2GQR ADP 3.37553
90 4ZGP ADP 3.41297
91 1W8S FBP 3.42205
92 4RF7 ARG 3.42857
93 5KR7 6X9 3.42857
94 2Z49 AMG 3.42857
95 5JDA AMP 3.42857
96 1LCF OXL 3.42857
97 1F9V ADP 3.45821
98 4XYM A12 3.47826
99 4XZ3 ACP 3.47826
100 1AUX AGS 3.53698
101 3KC1 2T6 3.56083
102 5D3X 4IP 3.59281
103 6CGD GNP 3.60656
104 6CGD AKN 3.60656
105 1CKN GTP 3.63636
106 1CKM GTP 3.63636
107 2QK4 ATP 3.71429
108 3WVR AMP 3.71429
109 5YJS SAL 3.71429
110 4NOS ITU 3.71429
111 2VL1 GLY GLY 3.71429
112 4LH7 1X8 3.71517
113 1HPG BOC ALA ALA PRO GLU 3.74332
114 4UWH JXM 3.82696
115 3BY9 SIN 3.84615
116 1NE6 SP1 3.88693
117 6GW4 CHO 3.90879
118 3TDV GDP 3.92157
119 4KU7 PCG 3.92157
120 4OUC 5ID 4
121 6G34 5ID 4
122 4OCJ NDG 4
123 5KJZ PCG 4
124 6EZ6 C5Z 4
125 5AE9 OKO 4
126 1MJT ITU 4.03458
127 1Y7P RIP 4.03587
128 2Q7D ANP 4.04624
129 4DDY DN6 4.18251
130 4NZN 2OU 4.24242
131 4NZN ANP 4.24242
132 5C1P ADP 4.24837
133 5C1P DAL DAL 4.24837
134 6ACS CIT 4.26357
135 2IF8 ADP 4.28571
136 1IA9 ANP 4.28571
137 2VPQ ANP 4.28571
138 5LXT ACP 4.28571
139 4WOE ADP 4.28571
140 4WOE 3S5 4.28571
141 5HSS 650 4.28571
142 4DS0 A2G GAL NAG FUC 4.29448
143 4FE2 AIR 4.31373
144 4FE2 ADP 4.31373
145 1JGS SAL 4.34783
146 4OIT MAN 4.42478
147 1GSA ADP 4.43038
148 5JAX 6J7 4.44444
149 1FWV SGA MAG FUC 4.47761
150 5F90 GLA GAL BGC 5VQ 4.48718
151 3C8F MT2 4.4898
152 1I7L ATP 4.53074
153 4Y24 TD2 4.54545
154 5VZ0 ADP 4.57143
155 4OCV ANP 4.57143
156 1P0Z FLC 4.58015
157 1UF5 CDT 4.62046
158 6FA4 D1W 4.62428
159 4DFU QUE 4.65839
160 5C4L 4XR 4.6729
161 5C4L SIS 4.6729
162 5I35 ANP 4.85714
163 3V4S ATP 4.85714
164 1F52 ADP 4.85714
165 5IM3 DTP 4.85714
166 4AZW ATP 4.85714
167 2PYW ADP 4.85714
168 1W2D ADP 4.90566
169 1W2D 4IP 4.90566
170 1P6O HPY 4.96894
171 3ACC 5GP 4.97238
172 4GYI ADP 5.03778
173 5W75 SUC 5.14286
174 4PZ6 GMP 5.14286
175 3E7S AT2 5.14286
176 3VSV XYP 5.14286
177 3IAE D7K 5.14286
178 1ZPD DPX 5.14286
179 2RDE C2E 5.17928
180 2XG5 EC5 5.20231
181 2XG5 EC2 5.20231
182 1TQP ATP 5.31915
183 4K7O EKZ 5.35714
184 2J9L ATP 5.40541
185 1SDW IYT 5.41401
186 1M0W ANP 5.42857
187 2IO8 ADP 5.42857
188 1E4E ADP 5.53936
189 3ORQ ADP 5.57029
190 5NM7 GLY 5.6391
191 1SU2 ATP 5.66038
192 3TY5 ATP 5.71429
193 3TY5 ADP 5.71429
194 1BW9 NAD 5.71429
195 1C1X HFA 5.71429
196 3ZW2 NAG GAL FUC 5.74713
197 5VM6 9EG 5.83942
198 3BP1 GUN 5.86207
199 6AR9 3L4 5.88235
200 3RET SAL 5.94059
201 3CF6 SP1 5.98802
202 5HV7 RBL 6
203 5YK1 ANP 6
204 1OKE BOG 6
205 2V2G BEZ 6.00858
206 1QK3 5GP 6.00858
207 3VPD ANP 6.04982
208 4GGZ BTN 6.08696
209 5TDF ADP 6.17284
210 2FB3 MET 6.17647
211 5XG5 A2G 6.2069
212 4RT1 C2E 6.25
213 4O1P ANP 6.28571
214 2PUL ACP 6.28571
215 5OES ADP 6.28571
216 1EHI ADP 6.28571
217 3DNT ATP 6.28571
218 2VQ5 HBA 6.46766
219 2YRX AMP 6.57143
220 5TDC NMM ILE PHE SER 6.57895
221 3TTM PUT 6.6474
222 2D5X L35 6.84932
223 5MRH Q9Z 6.85714
224 4OAV ACP 6.85714
225 1T36 ADP 6.85714
226 5ZCT ANP 6.86275
227 5DYO FLU 6.88073
228 3LQV ADE 6.95652
229 5U7W ADE 7.14286
230 6EAC ANP 7.14286
231 2QHS OCA 7.173
232 1UNQ 4IP 7.2
233 1S68 AMP 7.22892
234 5CIC 51R 7.40741
235 3W6G FLC 7.40741
236 4IX4 ADP 7.42857
237 4LO2 GAL BGC 7.43243
238 5Y4R C2E 7.48299
239 1SBR VIB 7.5
240 4LRJ ANP 7.69231
241 2P4S DIH 7.71429
242 5XLY C2E 7.82918
243 1OBD ATP 7.84314
244 2QHV OC9 8.09524
245 2VQD AP2 8.28571
246 2YVJ NAI 8.28571
247 6AC9 ANP 8.57143
248 3ZJX BOG 8.65052
249 4XMF HSM 8.69565
250 3SAO DBH 8.75
251 2QX0 PH2 8.80503
252 1YQC GLV 8.82353
253 2X3J ATP 8.85714
254 6DZN AE3 8.92019
255 4ZS4 ATP 9.12052
256 1H8P PC 9.17431
257 4JWK CTN 9.32642
258 5TT6 ATP 9.71429
259 4OFG PCG 9.72222
260 1S9D AFB 9.7561
261 4NS0 PIO 9.77444
262 3PDT ADP 10.1818
263 3TPV ADE 10.5714
264 2OX9 GAL NAG FUC 10.7143
265 3EW2 BTN 11.1111
266 5UFC DR2 11.2903
267 3VPC ADP 11.3475
268 3VPB ADP 11.3475
269 3WCZ CIT 11.3636
270 3Q60 ATP 11.4286
271 3HAV ATP 11.7057
272 2GQS C2R 11.8143
273 2GQS ADP 11.8143
274 2BKK ADP 11.8343
275 6E2B PT7 11.8421
276 5C8W PCG 11.8881
277 3WG3 A2G GAL NAG FUC 12.3596
278 4O4F ATP 12.5
279 4O4F IHP 12.5
280 5CKW ANP 12.8571
281 5WS9 OXL 12.8571
282 3VOT ADP 13.1429
283 1F5F DHT 13.1707
284 4WOH 4NP 13.253
285 1XVB BHL 13.5294
286 5DMZ ADP 14
287 4OH4 ANP 14.4144
288 5LPZ ADP 14.759
289 1KDK DHT 15.2542
290 2QLU ADE 15.2866
291 5HWV MBN 15.3846
292 4IJP 1EH 15.4286
293 4I94 ANP 15.6667
294 2RIO ADP 16
295 5EJL C2E 16.129
296 5LPB ADP 16.2162
297 4WW7 AMP 18.7739
298 4CYI ATP 18.8571
299 2CSN CKI 19.1919
300 3VHE 42Q 19.7143
301 3H0L ADP 20.2128
302 4YZC STU 20.5714
303 5C03 AGS 21.345
304 4Y0X ADP 22
305 5DZT AMP 22.2857
306 2PZI AXX 22.8571
307 4WOV 3SM 23.0284
308 4Q5H ANP 23.6842
309 6BFN DL1 25.1462
310 3HMO STU 25.4386
311 4JR7 GNP 26
312 4CRL C1I 26.8473
313 5OMY 9YE 26.8542
314 1Q8Y ADE 26.8571
315 1Q8Y ADP 26.8571
316 3VRY B43 27.1429
317 4IDT T28 27.1429
318 5BVE 4VG 27.4238
319 5N87 N66 27.476
320 5KO1 6UY 27.5618
321 5MY8 RXZ 27.7143
322 4E93 GUI 27.7143
323 3C1X CKK 27.7143
324 4BTK DTQ 27.8932
325 3UIM ANP 27.9141
326 6FYL 3NG 28
327 5UIU 8CG 28.1734
328 5T8O 76Z 28.3668
329 4H3P ANP 28.5714
330 4H3Q ANP 28.5714
331 3PP0 03Q 28.6982
332 4XH0 ADP 28.8571
333 3LXN MI1 28.9308
334 4QTB 38Z 29.1429
335 3KMW ATP 29.1513
336 1VJY 460 29.3729
337 3H9R TAK 29.697
338 4UX9 ANP 29.7143
339 3GNI ATP 29.7143
340 2H8H H8H 29.7143
341 6GWR FEW 29.8413
342 5Y86 HRM 30
343 2B9H ADP 30
344 6GZD LCI 30
345 2B9I ADP 30
346 2B9J ADP 30
347 3E8N ATP 30.2053
348 3E8N VRA 30.2053
349 5HCY 60D 30.2115
350 5QIN J2V 30.3797
351 5EOB 5QQ 30.4075
352 2WU6 DKI 30.5714
353 2B9F ADP 30.5714
354 5ZTN CUR 30.5714
355 2PVN P63 30.6818
356 4NFN 2KC 30.7443
357 6F3G CJN 30.8475
358 6ES0 BW8 30.9148
359 5W4W 9WG 31.1178
360 4KBA 1QM 31.1178
361 4GJ3 0XP 31.1258
362 4P5Z Q7M 31.1429
363 1OPK P16 31.1429
364 3PE2 E1B 31.1573
365 3ALN ANP 31.1927
366 4CLI 5P8 31.1927
367 5X8I SQZ 31.2139
368 4E1Z 0MX 31.2715
369 5JGA 6KC 31.4286
370 1CM8 ANP 31.4286
371 3LXK MI1 31.4985
372 5YF9 NIO 31.5634
373 3NW7 LGV 31.5961
374 4NST AF3 31.7143
375 4NST ADP 31.7143
376 4IZY 1J2 31.7143
377 4F9C 0SX 31.7143
378 6FYV 3NG 31.7507
379 5EH0 5NW 31.7829
380 6G33 5ID 31.8584
381 4U44 3D9 31.9277
382 1OUK 084 32
383 1Y57 MPZ 32
384 5HVJ ANP 32.0635
385 5WNL STU 32.1637
386 6GIN IR2 32.2259
387 3KRL KRL 32.2388
388 4LOO SB4 32.2857
389 4Y93 746 32.2857
390 2OO8 RAJ 32.4921
391 6A1G 9OL 32.5714
392 4Y8D 49J 32.6471
393 1K3A ACP 32.7759
394 3ORK AGS 32.7974
395 5OKT 9XK 32.8025
396 4Y85 499 32.8313
397 4NM5 ADP 32.8571
398 5TO8 7FM 32.9787
399 4AT3 LTI 33.1104
400 3PTG 932 33.1429
401 4WHZ 3NL 33.1429
402 3TTI KBI 33.1429
403 5EFQ ADP 33.4294
404 1O9U ADZ 34
405 5AWM ANP 34
406 3PLS ANP 34.2282
407 2JLD AG1 34.2857
408 3E7O 35F 34.2857
409 4QMN DB8 34.5161
410 3F7Z 34O 34.5714
411 3ZRM ZRM 34.5714
412 5AX9 4KT 34.7403
413 4UXL 5P8 34.7826
414 4AUA 4AU 34.8534
415 4ASE AV9 35.1275
416 4AU8 Z3R 35.1351
417 4YZN 4K5 35.1916
418 4EWH T77 35.2727
419 5NKB 8ZT 35.2941
420 5JFS 6K0 35.3896
421 5Y80 IRE 35.4633
422 3DAK ANP 35.5172
423 4YMJ 4EJ 35.5263
424 2HK5 1BM 35.5556
425 2BPM 529 35.5987
426 4XV1 904 35.6164
427 5HES 032 35.8306
428 5H2U 1N1 35.9551
429 3O0G 3O0 35.9589
430 1UNH IXM 35.9589
431 2F57 23D 36
432 3GGF GVD 36.2126
433 2A19 ANP 36.2676
434 6CZ3 FLJ 36.3636
435 2XVD AS6 36.4238
436 4X7Q 3YR 36.5385
437 3GC8 B45 36.5714
438 5M06 ADP 36.5942
439 4CFU 2WC 36.6337
440 5WO4 B7V 36.755
441 4G31 0WH 36.7893
442 1JPA ANP 36.859
443 4BCQ TJF 36.8771
444 4BCM T7Z 36.8771
445 4EUU BX7 36.9906
446 4BCN T9N 37
447 4CQE CQE 37.0504
448 4M69 ANP 37.0607
449 6GUE FB8 37.0861
450 5UPK ANP 37.2832
451 4AG8 AXI 37.3418
452 5LMK 6ZK 37.3737
453 4ITH RCM 37.415
454 3SLS 77D 37.5
455 3SLS ANP 37.5
456 5U6C 7YS 37.7778
457 3IGO ANP 38
458 2Y6O 1N1 38.1443
459 4K33 ACP 38.1538
460 2OFV 242 38.2671
461 2PVF ACP 38.3234
462 5CEO 50D 38.3333
463 4RFM 3P6 38.3459
464 6C7Y ADP 38.4615
465 5JKG 6LF 38.5852
466 4BHN BH9 38.6228
467 5HQ0 LZ9 38.7417
468 6GU6 1QK 38.7417
469 3GQI ACP 38.9571
470 5MJA 7O3 39.0164
471 5VC5 96M 39.1003
472 3DLS ADP 39.1045
473 5TA6 79D 39.1061
474 4FF8 14S 39.3189
475 1U59 STU 39.3728
476 4FL3 ANP 39.7143
477 6GQM F8H 39.939
478 3KN5 ANP 40
479 2YAB AMP 40
480 2WQN ADP 40
481 3EKK GS2 40.0651
482 4BFM ANP 40.1198
483 5USZ SKE 40.1384
484 5EKO N17 40.2857
485 4G17 0VN 40.303
486 3BU5 ATP 40.5229
487 1IR3 ANP 40.5229
488 4ONA UW1 40.5714
489 3RI1 3RH 40.5751
490 3SXS PP2 40.6716
491 4CSV STI 40.7273
492 3G5D 1N1 40.9091
493 4U0I 0LI 40.9524
494 2X2M X2M 41.0828
495 3C0G 3AM 41.1429
496 3HZT J60 41.1429
497 5UR1 YY9 41.1576
498 5VCV 1N1 41.1576
499 4N70 2HX 41.1585
500 4TWP AXI 41.3284
501 3FHR P4O 41.369
502 5FBN 5WF 41.6974
503 3FC2 IBI 41.791
504 3SRV S19 41.8773
505 2V7O DRN 41.9643
506 4F4P 0SB 42.4908
507 4I6H 1C8 42.5325
508 3GC0 AMP 42.5532
509 1BYG STU 42.8058
510 2J7T 274 43.0464
511 5DEY 59T 43.0976
512 3BZ3 YAM 43.1159
513 3CY2 MB9 43.3121
514 2WEL K88 43.4251
515 5IH9 6BF 43.5821
516 5XVG 8FX 44.0273
517 6E2O S0L 44.0678
518 3M2W L8I 44.1472
519 5DRB 5FJ 44.3299
520 2VZ6 FEF 44.7284
521 6CMJ F6J 44.8598
522 4KS7 X4Z 44.863
523 1ZY5 ANP 44.8845
524 4L9I 8PR 45.7143
525 4PNI KQQ 45.7143
526 5ZCO CHD 45.7627
527 4A4X JUP 46.2366
528 5A6N U7E 46.2898
529 2WEI VGG 46.3415
530 1PHK ATP 46.6443
531 4WNP 3RJ 47.0383
532 2VN9 GVD 47.1761
533 4FG8 ATP 47.9365
534 2ZV2 609 47.9866
535 4WNK 453 48.5714
536 2XK9 XK9 48.7578
537 5JZJ AN2 48.8215
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